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Aliases for NEUROD6 Gene

Aliases for NEUROD6 Gene

  • Neuronal Differentiation 6 2 3
  • Atoh2 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 2 3 4
  • Protein Atonal Homolog 2 3 4
  • BHLHa2 3 4
  • MATH2 3 6
  • Neurogenic Differentiation Factor 6 3
  • Neurogenic Differentiation 6 2
  • Brain My051 Protein 3
  • NeuroD6 4
  • Math-2 3
  • NEX1M 3
  • Nex1 3

External Ids for NEUROD6 Gene

Summaries for NEUROD6 Gene

Entrez Gene Summary for NEUROD6 Gene

  • This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]

GeneCards Summary for NEUROD6 Gene

NEUROD6 (Neuronal Differentiation 6) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROD6 Gene

  • Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD6 Gene

Genomics for NEUROD6 Gene

Genomic Location for NEUROD6 Gene

Start:
31,337,461 bp from pter
End:
31,340,924 bp from pter
Size:
3,464 bases
Orientation:
Minus strand

Genomic View for NEUROD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEUROD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD6 Gene

Regulatory Elements for NEUROD6 Gene

Proteins for NEUROD6 Gene

  • Protein details for NEUROD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NK8-NDF6_HUMAN
    Recommended name:
    Neurogenic differentiation factor 6
    Protein Accession:
    Q96NK8
    Secondary Accessions:
    • Q548T9
    • Q9H3H6

    Protein attributes for NEUROD6 Gene

    Size:
    337 amino acids
    Molecular mass:
    38705 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    SequenceCaution:
    • Sequence=AAG43167.1; Type=Frameshift; Positions=300, 307; Evidence={ECO:0000305};

neXtProt entry for NEUROD6 Gene

Proteomics data for NEUROD6 Gene at MOPED

Post-translational modifications for NEUROD6 Gene

No Post-translational modifications

Other Protein References for NEUROD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROD6 Gene

Domains for NEUROD6 Gene

Gene Families for NEUROD6 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NEUROD6 Gene

UniProtKB/Swiss-Prot:

NDF6_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q96NK8
genes like me logo Genes that share domains with NEUROD6: view

Function for NEUROD6 Gene

Molecular function for NEUROD6 Gene

UniProtKB/Swiss-Prot Function: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROD6: view
genes like me logo Genes that share phenotypes with NEUROD6: view

Animal Models for NEUROD6 Gene

MGI Knock Outs for NEUROD6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NEUROD6 Gene

Localization for NEUROD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROD6 Gene COMPARTMENTS Subcellular localization image for NEUROD6 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROD6: view

Pathways for NEUROD6 Gene

SuperPathways for NEUROD6 Gene

No Data Available

Interacting Proteins for NEUROD6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297142%0d%0a9606.ENSP00000343040%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000297142 Q96NK8-NDF6_HUMAN for NEUROD6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0021542 dentate gyrus development IEA --
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with NEUROD6: view

No data available for Pathways by source for NEUROD6 Gene

Transcripts for NEUROD6 Gene

mRNA/cDNA for NEUROD6 Gene

Unigene Clusters for NEUROD6 Gene

Neuronal differentiation 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD6 Gene

No ASD Table

Relevant External Links for NEUROD6 Gene

GeneLoc Exon Structure for
NEUROD6
ECgene alternative splicing isoforms for
NEUROD6

Expression for NEUROD6 Gene

mRNA expression in normal human tissues for NEUROD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD6 Gene

This gene is overexpressed in Brain - Hippocampus (13.6), Brain - Anterior cingulate cortex (BA24) (11.9), Brain - Frontal Cortex (BA9) (9.7), Brain - Cortex (8.1), and Brain - Amygdala (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEUROD6 Gene

SOURCE GeneReport for Unigene cluster for NEUROD6 Gene Hs.45152

genes like me logo Genes that share expressions with NEUROD6: view

Orthologs for NEUROD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROD6 36
  • 99.8 (n)
  • 100 (a)
NEUROD6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROD6 36
  • 96.83 (n)
  • 99.7 (a)
NEUROD6 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROD6 36
  • 97.33 (n)
  • 100 (a)
NEUROD6 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurod6 36
  • 94.16 (n)
  • 98.22 (a)
Neurod6 16
Neurod6 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEUROD6 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD6 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurod6 36
  • 94.07 (n)
  • 98.52 (a)
chicken
(Gallus gallus)
Aves NEUROD6 36
  • 86.65 (n)
  • 94.07 (a)
NEUROD6 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEUROD6 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia neurod6-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod6 36
  • 79.33 (n)
  • 84.57 (a)
zebrafish
(Danio rerio)
Actinopterygii atoh2a 36
neurod6a 36
  • 64.58 (n)
  • 64.58 (a)
neurod6a 37
  • 55 (a)
OneToMany
neurod6b 37
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnd-1 36
  • 50.11 (n)
  • 45.03 (a)
cnd-1 37
  • 36 (a)
ManyToMany
ngn-1 37
  • 35 (a)
ManyToMany
Species with no ortholog for NEUROD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD6 Gene

ENSEMBL:
Gene Tree for NEUROD6 (if available)
TreeFam:
Gene Tree for NEUROD6 (if available)

Paralogs for NEUROD6 Gene

Selected SIMAP similar genes for NEUROD6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROD6: view

Variants for NEUROD6 Gene

Sequence variations from dbSNP and Humsavar for NEUROD6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2191888 -- 31,342,890(+) CATGG(A/C)TGTAC upstream-variant-2KB
rs2215617 -- 31,342,713(+) GGAGC(A/G)TAAGT upstream-variant-2KB
rs2233397 -- 31,341,354(-) AGAAG(C/T)TGTTC upstream-variant-2KB
rs2233398 -- 31,341,280(-) ACACT(C/T)ATAAG upstream-variant-2KB
rs2233399 -- 31,341,269(-) TTACA(C/T)GCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEUROD6 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv830940 CNV Gain 17160897

Relevant External Links for NEUROD6 Gene

HapMap Linkage Disequilibrium report
NEUROD6

Disorders for NEUROD6 Gene

Relevant External Links for NEUROD6

Genetic Association Database (GAD)
NEUROD6
Human Genome Epidemiology (HuGE) Navigator
NEUROD6
genes like me logo Genes that share disorders with NEUROD6: view

No data available for UniProtKB/Swiss-Prot for NEUROD6 Gene

Publications for NEUROD6 Gene

  1. Cloning, chromosome localization and features of a novel human gene, MATH2. (PMID: 12357074) Guo L. … Mao Y.-M. (J. Genet. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PMID: 19733838) RibasAcs M. … Cormand B. (Biol. Psychiatry 2009) 3 49
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 49

Products for NEUROD6 Gene

Sources for NEUROD6 Gene

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