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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROD6 Gene

protein-coding   GIFtS: 48
GCID: GC07M031343

Neuronal Differentiation 6

(Previous name: neurogenic differentiation 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuronal Differentiation 61 2     Math-22
Class A Basic Helix-Loop-Helix Protein 22 3     NEX1M2
Protein Atonal Homolog 22 3     Nex12
bHLHa22 3     Brain My051 Protein2
MATH22 5     Neurogenic Differentiation Factor 62
ATOH23 5     BHLHA23
Neurogenic Differentiation 61     NeuroD63
Atoh22     

External Ids:    HGNC: 138041   Entrez Gene: 639742   Ensembl: ENSG000001646007   OMIM: 6115135   UniProtKB: Q96NK83   

Export aliases for NEUROD6 gene to outside databases

Previous GC identifers: GC07M031019 GC07M031119 GC07M031150


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEUROD6 Gene:
This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein
may be involved in the development and differentiation of the nervous system. (provided by RefSeq, Nov 2012)

GeneCards Summary for NEUROD6 Gene: 
NEUROD6 (neuronal differentiation 6) is a protein-coding gene. Diseases associated with NEUROD6 include dyslexia, and neuronitis. GO annotations related to this gene include protein dimerization activity and DNA binding. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NDF6_HUMAN, Q96NK8
Function: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor
involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its
own gene (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROD6 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   E2F-2   HEN1   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15.1

NEUROD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M031343:  view genomic region     (about GC identifiers)

Start:
31,377,075 bp from pter      End:
31,380,538 bp from pter
Size:
3,464 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 31,426,281-31,429,739     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDF6_HUMAN, Q96NK8 (See protein sequence)
Recommended Name: Neurogenic differentiation factor 6  
Size: 337 amino acids; 38705 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAG43167.1; Type=Frameshift; Positions=300, 307;
Secondary accessions: Q548T9 Q9H3H6

Explore the universe of human proteins at neXtProt for NEUROD6: NX_Q96NK8

Explore proteomics data for NEUROD6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NK8

  • NEUROD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEUROD6 Protein Expression
    REFSEQ proteins: NP_073565.2  
    ENSEMBL proteins: 
     ENSP00000297142  

    Human Recombinant Protein Products for NEUROD6: 
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    OriGene Protein Over-expression Lysate for NEUROD6
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    OriGene Custom Protein Services for NEUROD6
    GenScript Custom Purified and Recombinant Proteins Services for NEUROD6
    Novus Biologicals NEUROD6 Proteins
    Novus Biologicals NEUROD6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEUROD6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NEUROD6 for ontologies           About GeneDecksing



    NEUROD6 Antibody Products: 
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    Assay Products for NEUROD6: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEUROD6 
    Cloud-Clone Corp. CLIAs for NEUROD6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR011598 bHLH_dom
     IPR022575 Neurogenic_DUF
     IPR016637 TF_bHLH_NeuroD

    Graphical View of Domain Structure for InterPro Entry Q96NK8

    ProtoNet protein and cluster: Q96NK8

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NDF6_HUMAN, Q96NK8
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDF6_HUMAN, Q96NK8
    Function: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor
    involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its
    own gene (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    NEUROD6 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Neurod6):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size 
     homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis  normal 

    NEUROD6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurod6tm1Kan for NEUROD6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEUROD6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEUROD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROD6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROD6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD6
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD6 (see all 13):
    hsa-miR-579 hsa-miR-495 hsa-miR-7-2* hsa-miR-128 hsa-miR-3681* hsa-miR-1257 hsa-miR-153 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEUROD6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROD6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROD6
    Sirion Biotech Customized adenovirus for overexpression of NEUROD6

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEUROD6 (see all 7)
    OriGene ORF clones in mouse, rat for NEUROD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROD6 (NM_022728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD6
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                         Customized lentivirus expression plasmids for stable overexpression of NEUROD6 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEUROD6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NEUROD6
        Selected targets of C/EBPbeta




    NEUROD6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROD6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NEUROD6 (Q96NK83 ENSP000002971424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0021542dentate gyrus development IEA--
    GO:0030154cell differentiation IEA--

    NEUROD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROD6 (NDF6)

    Search CenterWatch for drugs/clinical trials and news about NEUROD6 / NDF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEUROD6 gene: 
    NM_022728.3  

    Unigene Cluster for NEUROD6:

    Neuronal differentiation 6
    Hs.45152  [show with all ESTs]
    Unigene Representative Sequence: AF248954
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297142(uc003tch.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD6
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD6 (see all 13):
    hsa-miR-579 hsa-miR-495 hsa-miR-7-2* hsa-miR-128 hsa-miR-3681* hsa-miR-1257 hsa-miR-153 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEUROD6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROD6
    Clone
    Products:
         
    OriGene clones in human, mouse for NEUROD6 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROD6 (NM_022728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD6
    Sirion Biotech Customized lentivirus for stable overexpression of NEUROD6 
                         Customized lentivirus expression plasmids for stable overexpression of NEUROD6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NEUROD6
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROD6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROD6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD6

    Additional mRNA sequence: 

    AF063609.1 AF136169.1 AF248954.1 AK055238.1 AK289619.1 BC022560.1 BC035048.2 

    3 DOTS entries:

    DT.445048  DT.100812759  DT.95346064 

    24/38 AceView cDNA sequences (see all 38):

    AK055238 CR624239 NM_022728 BC022560 H18504 AF248954 D80123 BX478059 
    AW236965 U69205 BX453565 BI547130 BX419494 AF063609 AW163081 BX420750 
    M78507 BC035048 BG699059 CB155186 BX951578 AF136169 BG703083 D80122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROD6 expression in normal human tissues (normalized intensities)      NEUROD6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEUROD6 Expression
    About this image


    NEUROD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             superior temporal gyrus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier

    See NEUROD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROD6

    SOURCE GeneReport for Unigene cluster: Hs.45152
        SABiosciences Custom PCR Arrays for NEUROD6
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEUROD6 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurod61 , 5 neurogenic differentiation 61, 5 94.16(n)1
    98.22(a)1
      6 (27.53 cM)5
    119221  NM_009717.21  NP_033847.11 
     556778185 
    chicken
    (Gallus gallus)
    Aves NEUROD61 neurogenic differentiation 6 86.65(n)
    94.07(a)
      420754  XM_418852.3  XP_418852.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROD66
    Neurogenic differentiation factor
    90(a)
    1 ↔ 1
    6(44530862-44531875)
    African clawed frog
    (Xenopus laevis)
    Amphibia neurod6-A2 bHLH transcription factor atonal homolog 2 80.98(n)    AF306736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atoh2a2 atonal homolog 2a 72.57(n)   114414  AF115772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cato6
    ato6
    atonal
    24(a)
    12(a)
    many ↔ many
    many ↔ many
    2R(12165294-12165902)
    3R(4103514-4104996)


    ENSEMBL Gene Tree for NEUROD6 (if available)
    TreeFam Gene Tree for NEUROD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROD6 gene
    NEUROG32  NEUROD22  NEUROG22  NEUROD12  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    6 SIMAP similar genes for NEUROD6 using alignment to 2 protein entries:     NDF6_HUMAN (see all proteins):
    ATOH7    TAL2    NEUROD1    NEUROD2    NEUROD4    FERD3L

    NEUROD6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 SNPs in NEUROD6 are shown (see all 130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132465901,2
    C,F--31376584(+) CTTGGC/AGAGGT 1 -- ds50016Minor allele frequency- A:0.11NA WA 246
    rs1892932861,2
    --31376602(+) ACCCCA/GCCCAT 1 -- ds50010--------
    rs730860511,2
    C,F--31376787(+) TGTTTG/TTTGGA 1 -- ds50013Minor allele frequency- T:0.11WA NA EA 358
    rs570416541,2
    C,F--31376828(+) AGGTTA/GCCAGG 1 -- ds50012Minor allele frequency- G:0.11CSA WA 120
    rs1929224571,2
    --31376940(+) TTTAAG/TAAATT 1 -- ds50010--------
    rs1851051981,2
    --31377020(+) GAAAGC/TAGCTG 1 -- ds50010--------
    rs1451053241,2
    --31377029(+) TGTGTA/GCCAGG 1 -- ds50010--------
    rs102389181,2
    C,F,A,H--31377369(+) CAAATT/GCATCT 1 -- ut31 ese328Minor allele frequency- G:0.26NS EA NA WA CSA 2775
    rs1896812731,2
    --31377524(+) CAACCA/CAAATA 1 -- ut310--------
    rs1811559081,2
    --31377552(+) TGTGCA/CTGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NEUROD6 (31377075 - 31380538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NEUROD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436557CNV Deletion17901297
    nsv830940CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NEUROD6
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611513    OMIM disorders: --

    3 diseases for NEUROD6:    About MalaCards
    dyslexia    neuronitis    cerebritis


    NEUROD6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEUROD6
    Human Genome Epidemiology (HuGE) Navigator: NEUROD6 (1 document)

    Export disorders for NEUROD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEUROD6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NEUROD6)
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    1. Cloning, chromosome localization and features of a novel human gene, MATH2. (PubMed id 12357074)1, 2, 3 Guo L.... Mao Y.-M. (2002)
    2. Case-control study of six genes asymmetrically expres sed in the two cerebral hemispheres: association of BAIAP2 with attention-defic it/hyperactivity disorder. (PubMed id 19733838)1, 4 RibasAcs M....Cormand B. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (2007)
    6. AT-hook proteins stimulate induction of senescence markers triggered by 5-bromodeoxyuridine in mammalian cells. (PubMed id 15036409)1 Satou W....Ayusawa D. (2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
    8. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. (PubMed id 11748221)1 Dintilhac A. and Bernues J. (2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63974 HGNC: 13804 AceView: NEUROD6 Ensembl:ENSG00000164600 euGenes: HUgn63974
    ECgene: NEUROD6 H-InvDB: NEUROD6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEUROD6 gene:
    Search GeneIP for patents involving NEUROD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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