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Aliases for NEUROD6 Gene

Aliases for NEUROD6 Gene

  • Neuronal Differentiation 6 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 2 3 4
  • Protein Atonal Homolog 2 3 4
  • BHLHa2 3 4
  • Atoh2 3 4
  • Neurogenic Differentiation Factor 6 3
  • Neurogenic Differentiation 6 2
  • Brain My051 Protein 3
  • NeuroD6 4
  • Math-2 3
  • MATH2 3
  • NEX1M 3
  • Nex1 3

External Ids for NEUROD6 Gene

Previous GeneCards Identifiers for NEUROD6 Gene

  • GC07M031019
  • GC07M031119
  • GC07M031150

Summaries for NEUROD6 Gene

Entrez Gene Summary for NEUROD6 Gene

  • This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]

GeneCards Summary for NEUROD6 Gene

NEUROD6 (Neuronal Differentiation 6) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is NEUROD1.

UniProtKB/Swiss-Prot for NEUROD6 Gene

  • Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).

Additional gene information for NEUROD6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD6 Gene

Genomics for NEUROD6 Gene

Regulatory Elements for NEUROD6 Gene

Enhancers for NEUROD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H031310 1.2 ENCODE 11.5 +30.6 30623 0 NEUROD6 GC07P031321 PIR41419
GH07H031311 1.2 ENCODE 11.5 +29.5 29451 1 NEUROD6 GC07P031321 PIR41419
GH07H031309 0.4 FANTOM5 15.4 +31.3 31267 0 MAX NEUROD6 PPP1R17 GC07P031321 PIR41419
GH07H030447 0.5 dbSUPER 6 +892.2 892164 1 JUND REST RCOR1 ZBTB40 NOD1 NEUROD6 LOC101928268 ENSG00000272638
GH07H031335 0.5 ENCODE 0.7 +4.9 4936 1 CTCF RAD21 EZH2 NEUROD6 ENSG00000271027
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEUROD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROD6 Gene

Chromosome:
7
Start:
31,337,461 bp from pter
End:
31,340,924 bp from pter
Size:
3,464 bases
Orientation:
Minus strand

Genomic View for NEUROD6 Gene

Genes around NEUROD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD6 Gene

Proteins for NEUROD6 Gene

  • Protein details for NEUROD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NK8-NDF6_HUMAN
    Recommended name:
    Neurogenic differentiation factor 6
    Protein Accession:
    Q96NK8
    Secondary Accessions:
    • Q548T9
    • Q9H3H6

    Protein attributes for NEUROD6 Gene

    Size:
    337 amino acids
    Molecular mass:
    38705 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.
    SequenceCaution:
    • Sequence=AAG43167.1; Type=Frameshift; Positions=300, 307; Evidence={ECO:0000305};

neXtProt entry for NEUROD6 Gene

Post-translational modifications for NEUROD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROD6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NEUROD6

No data available for DME Specific Peptides for NEUROD6 Gene

Domains & Families for NEUROD6 Gene

Gene Families for NEUROD6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEUROD6: view

No data available for UniProtKB/Swiss-Prot for NEUROD6 Gene

Function for NEUROD6 Gene

Molecular function for NEUROD6 Gene

UniProtKB/Swiss-Prot Function:
Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity).

Phenotypes From GWAS Catalog for NEUROD6 Gene

Gene Ontology (GO) - Molecular Function for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROD6: view
genes like me logo Genes that share phenotypes with NEUROD6: view

Animal Models for NEUROD6 Gene

MGI Knock Outs for NEUROD6:

Animal Model Products

CRISPR Products

miRNA for NEUROD6 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEUROD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROD6 Gene

Localization for NEUROD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEUROD6 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROD6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEUROD6 Gene

Pathways & Interactions for NEUROD6 Gene

SuperPathways for NEUROD6 Gene

No Data Available

Interacting Proteins for NEUROD6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297142%0d%0a9606.ENSP00000343040%0d%0a
Selected Interacting proteins: ENSP00000297142 Q96NK8-NDF6_HUMAN for NEUROD6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NEUROD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with NEUROD6: view

No data available for Pathways by source and SIGNOR curated interactions for NEUROD6 Gene

Drugs & Compounds for NEUROD6 Gene

No Compound Related Data Available

Transcripts for NEUROD6 Gene

mRNA/cDNA for NEUROD6 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROD6 Gene

Neuronal differentiation 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEUROD6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD6 Gene

No ASD Table

Relevant External Links for NEUROD6 Gene

GeneLoc Exon Structure for
NEUROD6
ECgene alternative splicing isoforms for
NEUROD6

Expression for NEUROD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEUROD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD6 Gene

This gene is overexpressed in Brain - Hippocampus (x13.6), Brain - Anterior cingulate cortex (BA24) (x11.9), Brain - Frontal Cortex (BA9) (x9.7), Brain - Cortex (x8.1), and Brain - Amygdala (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROD6 Gene



NURSA nuclear receptor signaling pathways regulating expression of NEUROD6 Gene:

NEUROD6

SOURCE GeneReport for Unigene cluster for NEUROD6 Gene:

Hs.45152

Evidence on tissue expression from TISSUES for NEUROD6 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with NEUROD6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEUROD6 Gene

Orthologs for NEUROD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROD6 33 34
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia NEUROD6 33 34
  • 97.33 (n)
cow
(Bos Taurus)
Mammalia NEUROD6 33 34
  • 96.83 (n)
mouse
(Mus musculus)
Mammalia Neurod6 33 16 34
  • 94.16 (n)
rat
(Rattus norvegicus)
Mammalia Neurod6 33
  • 94.07 (n)
oppossum
(Monodelphis domestica)
Mammalia NEUROD6 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD6 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROD6 33 34
  • 86.65 (n)
lizard
(Anolis carolinensis)
Reptilia NEUROD6 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod6 33
  • 79.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia neurod6-A 33
zebrafish
(Danio rerio)
Actinopterygii neurod6a 33 34
  • 64.58 (n)
neurod6b 34
  • 63 (a)
OneToMany
atoh2a 33
worm
(Caenorhabditis elegans)
Secernentea cnd-1 33 34
  • 50.11 (n)
ngn-1 34
  • 35 (a)
ManyToMany
Species where no ortholog for NEUROD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD6 Gene

ENSEMBL:
Gene Tree for NEUROD6 (if available)
TreeFam:
Gene Tree for NEUROD6 (if available)

Paralogs for NEUROD6 Gene

(6) SIMAP similar genes for NEUROD6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEUROD6: view

Variants for NEUROD6 Gene

Sequence variations from dbSNP and Humsavar for NEUROD6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001840393 -- 31,339,171(+) CTGGC(C/T)TCTTA reference, missense
rs1001905328 -- 31,338,615(+) GGGGG(A/T)GTGGT reference, synonymous-codon
rs1001908402 -- 31,338,187(+) AGCCC(A/G)CAAGC utr-variant-3-prime
rs1001962404 -- 31,338,682(+) GTGCA(G/T)CCTCC reference, missense
rs1002748450 -- 31,342,246(+) GATCC(A/G)AATTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEUROD6 Gene

Variant ID Type Subtype PubMed ID
esv3891092 CNV gain 25118596
nsv1068321 OTHER inversion 25765185
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv830940 CNV gain 17160897

Variation tolerance for NEUROD6 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEUROD6 Gene

Disorders for NEUROD6 Gene

Relevant External Links for NEUROD6

Genetic Association Database (GAD)
NEUROD6
Human Genome Epidemiology (HuGE) Navigator
NEUROD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROD6

No disorders were found for NEUROD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEUROD6 Gene

Publications for NEUROD6 Gene

  1. Cloning, chromosome localization and features of a novel human gene, MATH2. (PMID: 12357074) Guo L … Mao Y (Journal of genetics 2002) 2 3 4 60
  2. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PMID: 19733838) Ribasés M … Cormand B (Biological psychiatry 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets. (PMID: 26395074) Fowler KD … Towfic F (Scientific reports 2015) 3 60
  5. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre RN … Friedlander Y (Journal of lipid research 2015) 3 60

Products for NEUROD6 Gene

Sources for NEUROD6 Gene

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