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Aliases for NEUROD4 Gene

Aliases for NEUROD4 Gene

  • Neuronal Differentiation 4 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 4 3 4
  • Neurogenic Differentiation 4 2 3
  • Protein Atonal Homolog 3 3 4
  • BHLHa4 3 4
  • ATH-3 3 4
  • Atoh3 3 4
  • ATH3 3 4
  • NeuroD4 4
  • MATH-3 3
  • MATH3 3

External Ids for NEUROD4 Gene

Previous GeneCards Identifiers for NEUROD4 Gene

  • GC12P055534
  • GC12P055130
  • GC12P053699
  • GC12P055413
  • GC12P052453

Summaries for NEUROD4 Gene

GeneCards Summary for NEUROD4 Gene

NEUROD4 (Neuronal Differentiation 4) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot for NEUROD4 Gene

  • Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD4 Gene

Genomics for NEUROD4 Gene

Regulatory Elements for NEUROD4 Gene

Enhancers for NEUROD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEUROD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROD4 Gene

55,019,945 bp from pter
55,030,017 bp from pter
10,073 bases
Plus strand

Genomic View for NEUROD4 Gene

Genes around NEUROD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD4 Gene

Proteins for NEUROD4 Gene

  • Protein details for NEUROD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neurogenic differentiation factor 4
    Protein Accession:
    Secondary Accessions:
    • B2RAC9

    Protein attributes for NEUROD4 Gene

    331 amino acids
    Molecular mass:
    37041 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROD4 Gene

Proteomics data for NEUROD4 Gene at MOPED

Post-translational modifications for NEUROD4 Gene

  • Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROD4 Gene

Domains & Families for NEUROD4 Gene

Gene Families for NEUROD4 Gene

Protein Domains for NEUROD4 Gene

Suggested Antigen Peptide Sequences for NEUROD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROD4: view

Function for NEUROD4 Gene

Molecular function for NEUROD4 Gene

GENATLAS Biochemistry:
neurogenesis regulator D4,rat homolog
UniProtKB/Swiss-Prot Function:
Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).
genes like me logo Genes that share phenotypes with NEUROD4: view

Animal Models for NEUROD4 Gene

MGI Knock Outs for NEUROD4:

Animal Model Products

CRISPR Products

miRNA for NEUROD4 Gene

miRTarBase miRNAs that target NEUROD4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROD4 Gene

Localization for NEUROD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD4 Gene

Subcellular locations from

Jensen Localization Image for NEUROD4 Gene COMPARTMENTS Subcellular localization image for NEUROD4 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for NEUROD4 Gene

Pathways & Interactions for NEUROD4 Gene

SuperPathways for NEUROD4 Gene

No Data Available

Interacting Proteins for NEUROD4 Gene

Gene Ontology (GO) - Biological Process for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0043010 camera-type eye development IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

No data available for Pathways by source and SIGNOR curated interactions for NEUROD4 Gene

Drugs & Compounds for NEUROD4 Gene

No Compound Related Data Available

Transcripts for NEUROD4 Gene

mRNA/cDNA for NEUROD4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROD4 Gene

Neuronal differentiation 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD4 Gene

No ASD Table

Relevant External Links for NEUROD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEUROD4 Gene

mRNA expression in normal human tissues for NEUROD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD4 Gene

This gene is overexpressed in Pituitary (x50.0).

Protein differential expression in normal tissues from HIPED for NEUROD4 Gene

This gene is overexpressed in Plasma (52.6) and Serum (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROD4 Gene

SOURCE GeneReport for Unigene cluster for NEUROD4 Gene Hs.591024

genes like me logo Genes that share expression patterns with NEUROD4: view

Protein tissue co-expression partners for NEUROD4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NEUROD4 Gene

Orthologs for NEUROD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NEUROD4 35
  • 89.7 (n)
  • 91.52 (a)
  • 92 (a)
(Canis familiaris)
Mammalia NEUROD4 35
  • 90.33 (n)
  • 92.75 (a)
  • 93 (a)
(Mus musculus)
Mammalia Neurod4 35
  • 87.37 (n)
  • 88.79 (a)
Neurod4 16
Neurod4 36
  • 89 (a)
(Pan troglodytes)
Mammalia NEUROD4 35
  • 99.3 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Neurod4 35
  • 85.96 (n)
  • 87.58 (a)
(Ornithorhynchus anatinus)
Mammalia NEUROD4 36
  • 67 (a)
(Gallus gallus)
Aves NEUROD4 35
  • 73.13 (n)
  • 79.39 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia NEUROD4 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod4 35
  • 64.86 (n)
  • 64.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xath-3 35
(Danio rerio)
Actinopterygii neurod4 35
  • 61.04 (n)
  • 62.74 (a)
neurod4 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea cnd-1 36
  • 38 (a)
ngn-1 36
  • 34 (a)
Species with no ortholog for NEUROD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD4 Gene

Gene Tree for NEUROD4 (if available)
Gene Tree for NEUROD4 (if available)

Paralogs for NEUROD4 Gene

(5) SIMAP similar genes for NEUROD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROD4: view

Variants for NEUROD4 Gene

Sequence variations from dbSNP and Humsavar for NEUROD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_012979 -
rs2135011 -- 55,021,740(-) TATAG(A/G)GTCTT intron-variant
rs2135012 -- 55,021,387(-) AAAGG(G/T)GGCTG intron-variant
rs17116816 -- 55,018,090(+) CTTAC(A/G)TCTGT upstream-variant-2KB
rs34924543 -- 55,018,729(+) TTTGA(-/C)CGCAT upstream-variant-2KB

Variation tolerance for NEUROD4 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NEUROD4 Gene

Disorders for NEUROD4 Gene

Relevant External Links for NEUROD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEUROD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEUROD4 Gene

Publications for NEUROD4 Gene

  1. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix- loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PMID: 11078465) Horikawa Y. … Bell G.I. (Diabetes 2000) 3 4 23 48 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3
  5. Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. (PMID: 17549667) Westerman B.A. … Oudejans C.B. (Int. J. Biol. Markers 2007) 23

Products for NEUROD4 Gene

Sources for NEUROD4 Gene