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Aliases for NEUROD4 Gene

Aliases for NEUROD4 Gene

  • Neuronal Differentiation 4 2 3
  • ATH3 3 4 6
  • Class A Basic Helix-Loop-Helix Protein 4 3 4
  • Neurogenic Differentiation 4 2 3
  • Protein Atonal Homolog 3 3 4
  • BHLHa4 3 4
  • ATH-3 3 4
  • Atoh3 3 4
  • Neurogenic Differentiation Factor 4 3
  • NeuroD4 4
  • MATH-3 3
  • MATH3 3

External Ids for NEUROD4 Gene

Summaries for NEUROD4 Gene

GeneCards Summary for NEUROD4 Gene

NEUROD4 (Neuronal Differentiation 4) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is BHLHA15.

UniProtKB/Swiss-Prot for NEUROD4 Gene

  • Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD4 Gene

Genomics for NEUROD4 Gene

Genomic Location for NEUROD4 Gene

Start:
55,019,945 bp from pter
End:
55,030,017 bp from pter
Size:
10,073 bases
Orientation:
Plus strand

Genomic View for NEUROD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEUROD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD4 Gene

Regulatory Elements for NEUROD4 Gene

Proteins for NEUROD4 Gene

  • Protein details for NEUROD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD90-NDF4_HUMAN
    Recommended name:
    Neurogenic differentiation factor 4
    Protein Accession:
    Q9HD90
    Secondary Accessions:
    • B2RAC9

    Protein attributes for NEUROD4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37041 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROD4 Gene

Proteomics data for NEUROD4 Gene at MOPED

Post-translational modifications for NEUROD4 Gene

  • Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.

Other Protein References for NEUROD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROD4 Gene

Domains for NEUROD4 Gene

Gene Families for NEUROD4 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for NEUROD4 Gene

UniProtKB/Swiss-Prot:

NDF4_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q9HD90
genes like me logo Genes that share domains with NEUROD4: view

Function for NEUROD4 Gene

Molecular function for NEUROD4 Gene

GENATLAS Biochemistry: neurogenesis regulator D4,rat homolog
UniProtKB/Swiss-Prot Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROD4: view
genes like me logo Genes that share phenotypes with NEUROD4: view

Animal Models for NEUROD4 Gene

MGI Knock Outs for NEUROD4:

miRNA for NEUROD4 Gene

miRTarBase miRNAs that target NEUROD4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NEUROD4 Gene

Localization for NEUROD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROD4 Gene COMPARTMENTS Subcellular localization image for NEUROD4 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

Pathways for NEUROD4 Gene

SuperPathways for NEUROD4 Gene

No Data Available

Interacting Proteins for NEUROD4 Gene

Gene Ontology (GO) - Biological Process for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007405 neuroblast proliferation IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

No data available for Pathways by source for NEUROD4 Gene

Transcripts for NEUROD4 Gene

mRNA/cDNA for NEUROD4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROD4 Gene

Neuronal differentiation 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD4 Gene

No ASD Table

Relevant External Links for NEUROD4 Gene

GeneLoc Exon Structure for
NEUROD4
ECgene alternative splicing isoforms for
NEUROD4

Expression for NEUROD4 Gene

mRNA expression in normal human tissues for NEUROD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD4 Gene

This gene is overexpressed in Pituitary (50.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEUROD4 Gene

SOURCE GeneReport for Unigene cluster for NEUROD4 Gene Hs.591024

genes like me logo Genes that share expressions with NEUROD4: view

Orthologs for NEUROD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROD4 36
  • 99.3 (n)
  • 99.7 (a)
NEUROD4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEUROD4 36
  • 89.7 (n)
  • 91.52 (a)
NEUROD4 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEUROD4 36
  • 90.33 (n)
  • 92.75 (a)
NEUROD4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurod4 36
  • 87.37 (n)
  • 88.79 (a)
Neurod4 16
Neurod4 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD4 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurod4 36
  • 85.96 (n)
  • 87.58 (a)
chicken
(Gallus gallus)
Aves NEUROD4 36
  • 73.13 (n)
  • 79.39 (a)
NEUROD4 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEUROD4 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xath-3 36
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod4 36
  • 64.86 (n)
  • 64.54 (a)
zebrafish
(Danio rerio)
Actinopterygii neurod4 36
  • 61.04 (n)
  • 62.74 (a)
neurod4 37
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cnd-1 37
  • 38 (a)
ManyToMany
ngn-1 37
  • 34 (a)
ManyToMany
Species with no ortholog for NEUROD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD4 Gene

ENSEMBL:
Gene Tree for NEUROD4 (if available)
TreeFam:
Gene Tree for NEUROD4 (if available)

Paralogs for NEUROD4 Gene

Selected SIMAP similar genes for NEUROD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROD4: view

Variants for NEUROD4 Gene

Sequence variations from dbSNP and Humsavar for NEUROD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1386801 -- 55,020,746(+) CGGAG(C/G)GGGAG intron-variant
rs1394589 -- 55,022,773(-) TCTGT(A/G)GCAAG intron-variant
rs1394590 -- 55,022,147(-) GGGCA(A/C)AATGA intron-variant
rs1488033 -- 55,019,846(+) TGGCC(A/G)GAGGA upstream-variant-2KB
rs1532833 -- 55,022,257(-) ACCAT(A/C)TCACA intron-variant

Relevant External Links for NEUROD4 Gene

HapMap Linkage Disequilibrium report
NEUROD4

No data available for Structural Variations from Database of Genomic Variants (DGV) for NEUROD4 Gene

Disorders for NEUROD4 Gene

Relevant External Links for NEUROD4

Genetic Association Database (GAD)
NEUROD4
Human Genome Epidemiology (HuGE) Navigator
NEUROD4
genes like me logo Genes that share disorders with NEUROD4: view

No data available for UniProtKB/Swiss-Prot for NEUROD4 Gene

Publications for NEUROD4 Gene

  1. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix- loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PMID: 11078465) Horikawa Y. … Bell G.I. (Diabetes 2000) 3 4 23 49
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 49

Products for NEUROD4 Gene

Sources for NEUROD4 Gene

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