Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEUROD4 Gene

Aliases for NEUROD4 Gene

  • Neuronal Differentiation 4 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 4 3 4
  • Neurogenic Differentiation 4 2 3
  • Protein Atonal Homolog 3 3 4
  • BHLHa4 3 4
  • ATH-3 3 4
  • Atoh3 3 4
  • ATH3 3 4
  • Neurogenic Differentiation Factor 4 3
  • NeuroD4 4
  • MATH-3 3
  • MATH3 3

External Ids for NEUROD4 Gene

Previous GeneCards Identifiers for NEUROD4 Gene

  • GC12P055534
  • GC12P055130
  • GC12P053699
  • GC12P055413
  • GC12P052453

Summaries for NEUROD4 Gene

GeneCards Summary for NEUROD4 Gene

NEUROD4 (Neuronal Differentiation 4) is a Protein Coding gene. Diseases associated with NEUROD4 include Congenital Stationary Night Blindness. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NEUROD1.

UniProtKB/Swiss-Prot for NEUROD4 Gene

  • Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEUROD4 Gene

Genomics for NEUROD4 Gene

Regulatory Elements for NEUROD4 Gene

Enhancers for NEUROD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F055060 0.6 Ensembl 12.1 +41.0 40956 0.6 PKNOX1 MAFG JUNB RELA ZNF316 EED IKZF1 NFYB ETV6 NFE2 NEUROD4 PDE1B PIR43661 OR9K1P
GH12F054997 0.5 ENCODE 12 -21.7 -21714 1.3 ZNF680 POU5F1 KDM1A NEUROD4 METTL7B TESPA1 GC12M054982
GH12F055074 0.6 ENCODE 11.6 +55.0 55007 0.2 NEUROD4 TESPA1 PIR43661 OR9K1P
GH12F055068 0.6 ENCODE 11.6 +48.7 48687 0.2 ZNF263 CTCF ZNF654 REST RAD21 SMARCA4 POLR2A GLIS1 ZNF341 ZNF143 NEUROD4 TESPA1 PIR43661 OR9K1P
GH12F055073 1 ENCODE 11.6 +53.3 53287 0.2 CTCF ZNF654 MAX TRIM22 REST RAD21 SMC3 ZNF143 NEUROD4 TESPA1 PIR43661 OR9K1P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NEUROD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEUROD4 Gene

Chromosome:
12
Start:
55,019,945 bp from pter
End:
55,030,017 bp from pter
Size:
10,073 bases
Orientation:
Plus strand

Genomic View for NEUROD4 Gene

Genes around NEUROD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEUROD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEUROD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEUROD4 Gene

Proteins for NEUROD4 Gene

  • Protein details for NEUROD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD90-NDF4_HUMAN
    Recommended name:
    Neurogenic differentiation factor 4
    Protein Accession:
    Q9HD90
    Secondary Accessions:
    • B2RAC9

    Protein attributes for NEUROD4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37041 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for NEUROD4 Gene

Post-translational modifications for NEUROD4 Gene

  • Serine or threonine phosphorylation within the basic region may regulate neurogenic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEUROD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEUROD4 Gene

Domains & Families for NEUROD4 Gene

Gene Families for NEUROD4 Gene

Suggested Antigen Peptide Sequences for NEUROD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD90

UniProtKB/Swiss-Prot:

NDF4_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with NEUROD4: view

Function for NEUROD4 Gene

Molecular function for NEUROD4 Gene

GENATLAS Biochemistry:
neurogenesis regulator D4,rat homolog
UniProtKB/Swiss-Prot Function:
Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity).

Gene Ontology (GO) - Molecular Function for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NEUROD4: view
genes like me logo Genes that share phenotypes with NEUROD4: view

Animal Models for NEUROD4 Gene

MGI Knock Outs for NEUROD4:

Animal Model Products

miRNA for NEUROD4 Gene

miRTarBase miRNAs that target NEUROD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEUROD4 Gene

Localization for NEUROD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEUROD4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEUROD4 Gene COMPARTMENTS Subcellular localization image for NEUROD4 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

Pathways & Interactions for NEUROD4 Gene

SuperPathways for NEUROD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEUROD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with NEUROD4: view

No data available for Pathways by source and SIGNOR curated interactions for NEUROD4 Gene

Transcripts for NEUROD4 Gene

mRNA/cDNA for NEUROD4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEUROD4 Gene

Neuronal differentiation 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEUROD4 Gene

No ASD Table

Relevant External Links for NEUROD4 Gene

GeneLoc Exon Structure for
NEUROD4
ECgene alternative splicing isoforms for
NEUROD4

Expression for NEUROD4 Gene

mRNA expression in normal human tissues for NEUROD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEUROD4 Gene

This gene is overexpressed in Pituitary (x50.0).

Protein differential expression in normal tissues from HIPED for NEUROD4 Gene

This gene is overexpressed in Plasma (52.6) and Serum (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEUROD4 Gene



Protein tissue co-expression partners for NEUROD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEUROD4 Gene:

NEUROD4

SOURCE GeneReport for Unigene cluster for NEUROD4 Gene:

Hs.591024
genes like me logo Genes that share expression patterns with NEUROD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NEUROD4 Gene

Orthologs for NEUROD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEUROD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEUROD4 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia NEUROD4 34 35
  • 90.33 (n)
cow
(Bos Taurus)
Mammalia NEUROD4 34 35
  • 89.7 (n)
mouse
(Mus musculus)
Mammalia Neurod4 34 16 35
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Neurod4 34
  • 85.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NEUROD4 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEUROD4 34 35
  • 73.13 (n)
lizard
(Anolis carolinensis)
Reptilia NEUROD4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurod4 34
  • 64.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xath-3 34
zebrafish
(Danio rerio)
Actinopterygii neurod4 34 35
  • 61.04 (n)
worm
(Caenorhabditis elegans)
Secernentea cnd-1 35
  • 38 (a)
ManyToMany
ngn-1 35
  • 34 (a)
ManyToMany
Species where no ortholog for NEUROD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEUROD4 Gene

ENSEMBL:
Gene Tree for NEUROD4 (if available)
TreeFam:
Gene Tree for NEUROD4 (if available)

Paralogs for NEUROD4 Gene

(5) SIMAP similar genes for NEUROD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEUROD4: view

Variants for NEUROD4 Gene

Sequence variations from dbSNP and Humsavar for NEUROD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111319908 -- 55,027,195(+) GGCCC(A/G)CTCAC intron-variant, reference, synonymous-codon
rs111521777 -- 55,024,817(+) ATTTC(C/T)GTGCT intron-variant
rs11171224 -- 55,020,656(+) AACTG(C/T)TTTTC intron-variant
rs112645813 -- 55,028,821(+) TTTGC(-/AG)AGTGT intron-variant, utr-variant-3-prime
rs113557150 -- 55,025,350(+) GTTCT(-/GTTCCACTA)GTTCC intron-variant

Variation tolerance for NEUROD4 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEUROD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEUROD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEUROD4 Gene

Disorders for NEUROD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEUROD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEUROD4

Genetic Association Database (GAD)
NEUROD4
Human Genome Epidemiology (HuGE) Navigator
NEUROD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEUROD4
genes like me logo Genes that share disorders with NEUROD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEUROD4 Gene

Publications for NEUROD4 Gene

  1. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix- loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PMID: 11078465) Horikawa Y. … Bell G.I. (Diabetes 2000) 3 4 22 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. (PMID: 17549667) Westerman B.A. … Oudejans C.B. (Int. J. Biol. Markers 2007) 22 64

Products for NEUROD4 Gene

Sources for NEUROD4 Gene

Content
Loading form....