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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NEUROD4 Gene

protein-coding GIFtS: 49
GCID: GC12P055413

neuronal differentiation 4

(Previous name: neurogenic differentiation 4 )

Explore 2 diseases affiliated with
NEUROD4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuronal Differentiation 4¹ ²		Class A Basic Helix-Loop-Helix Protein 4² ³
ATH-3¹ ² ³		Protein Atonal Homolog 3² ³
Atoh3¹ ² ³		Neurogenic Differentiation Factor 4²
BHLHa4¹		ATOH3³
ATH3² ³ ⁵		BHLHA4³
MATH-3¹ ²		NeuroD4³
Neurogenic Differentiation 4¹ ²

External Ids:	HGNC: 13802¹	Entrez Gene: 58158²	Ensembl: ENSG00000123307⁷	OMIM: 611635⁵	UniProtKB: Q9HD90³

Export aliases for NEUROD4 gene to outside databases

Previous GC identifers: GC12P055534 GC12P055130 GC12P053699 GC12P052453

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90

Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation

of amacrine cell fate specification in the retina (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEUROD4 gene promoter:
SRF AP-1 SRF (504 AA) Olf-1 CUTL1 HNF-1A c-Ets-1 HNF-1 HSF2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEUROD4 promoter sequence

Search SABiosciences Chromatin IP Primers for NEUROD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.13

NEUROD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P055413: view genomic region (about GC identifiers)

Start:	55,413,729 bp from pter	End:	55,423,801 bp from pter
Size:	10,073 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90 (See protein sequence)

Recommended Name: Neurogenic differentiation factor 4

Size: 331 amino acids; 37041 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)

Subcellular location: Nucleus (Potential)

Secondary accessions: B2RAC9

Explore the universe of human proteins at neXtProt for NEUROD4: NX_Q9HD90

Post-translational modifications:

Serine or threonine phosphorylation within the basic region may regulate neurogenic activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HD90

NEUROD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067014.2

ENSEMBL proteins:

ENSP00000242994

Human Recombinant Protein Products for NEUROD4:

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	Novus Biologicals NEUROD4 Protein Novus Biologicals NEUROD4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NEUROD4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

NEUROD4 for ontologies About GeneDecksing

NEUROD4 Antibody Products:

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Assay Products for NEUROD4:

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	Uscn ELISAs and CLIAs for NEUROD4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEUROD4 for domains About GeneDecksing

3 InterPro domains/families:

IPR011598 HLH_dom

IPR022575 Neurogenic_DUF

IPR016637 TF_bHLH_NeuroD

Graphical View of Domain Structure for InterPro Entry Q9HD90

ProtoNet protein and cluster: Q9HD90

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NDF4_HUMAN, Q9HD90

Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation

of amacrine cell fate specification in the retina (By similarity)

Genatlas biochemistry entry for NEUROD4:

neurogenesis regulator D4,rat homolog

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

NEUROD4 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Neurod4):

behavior/neurological	cellular	growth/size	mortality/aging	nervous system
vision/eye

NEUROD4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Neurod4^tm1Kag for NEUROD4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NEUROD4

miRNA Products:		OriGene 3'-UTR Clone: NEUROD4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD4
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD4 (see all 46):
		hsa-miR-302d hsa-miR-520e hsa-miR-128 hsa-miR-488 hsa-miR-218 hsa-miR-183* hsa-miR-372 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: NEUROD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROD4 (see all 7) OriGene shRNA RFP: NEUROD4 OriGene siRNA: NEUROD4
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NEUROD4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEUROD4 (NM_021191)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEUROD4
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NEUROD4

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for NEUROD4 (Q9HD90³ ENSP00000242994⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RUNX1T1	Q06455³	I2D: score=1
GABRB1	ENSP00000295454⁴	STRING: ENSP00000295454
LRRN2	ENSP00000356143⁴	STRING: ENSP00000356143

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0007405	neuroblast proliferation	IEA	--

NEUROD4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NEUROD4
Search CenterWatch for drugs/clinical trials and news about NEUROD4 / NDF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NEUROD4 gene:

NM_021191.2

Unigene Cluster for NEUROD4:

Neuronal differentiation 4

Hs.591024 [show with all ESTs]

Unigene Representative Sequence: NM_021191

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000242994(uc001sgp.4)

miRNA Products:		OriGene 3'-UTR Clone: NEUROD4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD4
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD4 (see all 46):
		hsa-miR-302d hsa-miR-520e hsa-miR-128 hsa-miR-488 hsa-miR-218 hsa-miR-183* hsa-miR-372 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: NEUROD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROD4 (see all 7) OriGene shRNA RFP: NEUROD4 OriGene siRNA: NEUROD4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NEUROD4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEUROD4 (NM_021191)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD4
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROD4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROD4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD4

Additional cDNA sequence:

AK314136.1 BC040961.1

1 DOTS entry:

DT.97836779

22 AceView cDNA sequences:

AA679237 BC040961 BM683125 BM661723 BM450929 NM_021191 BM689505 BM661495

BX954802 BX281568 BM702746 BU729797 AA364606 AA663038 BM669993 BM689756

BM699332 BM719169 AA179161 CK301083 AV751104 AA179353

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NEUROD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAAGCCT

About this image

NEUROD4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Ganglion Cell Layer

Ganglion Precursor Cells

Ganglion, Retina

Eye

Neuroblastic Layer

Early Retinal Progenitor Cells

Retina

Eye

Ganglion Cell Layer

Horizontal Precursor Cells

Horizontal, Retina

Eye

Inner Nuclear Layer

Bipolar Precursor Cells

Bipolar, Retina

Eye

Inner Nuclear Layer

Early Amacrine Precursor Cells

Amacrine, Retina

Eye

Inner Nuclear Layer

Late Amacrine Precursor Cells

Amacrine, Retina

Amacrine, Retina

Mature Rod Bipolar Cells

Bipolar, Retina

Bone

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

See NEUROD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEUROD4

SOURCE GeneReport for Unigene cluster: Hs.591024

SABiosciences Custom PCR Arrays for NEUROD4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROD4 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NEUROD4 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NEUROD4¹	neurogenic differentiation 4	73.13(n) 79.39(a)		395959 NM_205076.1 NP_990407.1
lizard (Anolis carolinensis)	Reptilia	NEUROD4⁶	--	74(a)	1 ↔ 1	GL343252.1(1154747-1155742)
African clawed frog (Xenopus laevis)	Amphibia	Xath-3²	xenopus atonal homolog-3	73.74(n)		D85188.1
zebrafish (Danio rerio)	Actinopterygii	neurod4²	neurogenic differentiation 4	75.13(n)		266958 AY036624.1
worm (Caenorhabditis elegans)	Secernentea	cnd-1⁶	Neurogenic differentiation factor 1	34(a)	1 → many	III(5240554-5242069)

ENSEMBL Gene Tree for NEUROD4 (if available)
TreeFam Gene Tree for NEUROD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NEUROD4 gene

NEUROG3² FERD3L² NEUROD2² NEUROD1² NEUROD6² ATOH1² NEUROG2² BHLHA15²

PTF1A² ATOH7² NEUROG1²

5 SIMAP similar genes for NEUROD4 using alignment to 1 protein entry: NDF4_HUMAN:

NEUROD1 ATOH7 NEUROD6 FERD3L NEUROD2

NEUROD4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140005600^1,2		--	55411787(+)	`TGTACA/GCTTGT`	1	--	us2k¹		0	--	--	--	--
rs147224905^1,2		--	55411817(+)	`CACAT-/ACACACA`	1	--	us2k¹		0	--	--	--	--
rs17116816^1,2	C,F,H	--	55411874(+)	`CTTACA/GTCTGT`	1	--	us2k¹ tfbs³		19		NA NS EA	1824
rs182865179^1,2		--	55411971(+)	`ACTCCC/TTGCCC`	1	--	us2k¹		0	--	--	--	--
rs187190410^1,2		--	55411991(+)	`TCACAA/GGCATC`	1	--	us2k¹		0	--	--	--	--
rs75899063^1,2	F	--	55412106(+)	`TCCTAG/AACATA`	1	--	us2k¹		1		WA	118
rs143875218^1,2		--	55412200(+)	`GTTTAA/TTTATT`	1	--	us2k¹		0	--	--	--	--
rs191499806^1,2	C	--	55412514(+)	`TTTGAC/TGCATG`	1	--	us2k¹		0	--	--	--	--
rs116395797^1,2		--	55412519(+)	`CGCATG/CTGCTA`	1	--	us2k¹		1		WA	118
rs7961072^1,2	C,F,A,H	--	55412550(+)	`GATTCT/CCAAAA`	1	--	us2k¹		19		NS EA NA WA	1994

HapMap Linkage Disequilibrium report for NEUROD4 (55413729 - 55423801 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEUROD4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROD4

DNA2.0 Custom Variant and Variant Library Synthesis for NEUROD4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEUROD4 for disorders           About GeneDecksing

OMIM gene information: 611635    OMIM disorders: --

2 diseases for NEUROD4:    About MalaCards

neuronitis neuroendocrine tumor

Genetic Association Database (GAD): NEUROD4
Human Genome Epidemiology (HuGE) Navigator: NEUROD4 (2 documents)

Export disorders for NEUROD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NEUROD4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NEUROD4)

Utopia: connect your pdf to the dynamic
world of online information

Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix- loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PubMed id 11078465)^{1, 2, 4, 9} Horikawa Y.... Bell G.I. (2000)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)¹ GratacA^s M....Carracedo A. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. (PubMed id 17549667)⁹ Westerman B.A....Oudejans C.B. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58158	HGNC: 13802	AceView: NEUROD4	Ensembl:ENSG00000123307	euGenes: HUgn58158
ECgene: NEUROD4	H-InvDB: NEUROD4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NEUROD4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NEUROD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NEUROD4 gene:
Search GeneIP for patents involving NEUROD4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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neuronal differentiation 4

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NEUROD4 Gene

neuronal differentiation 4

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Other Databases showing NEUROD4 gene

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for NEUROD4 gene

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for NEUROD4 gene

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for NEUROD4 gene

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for NEUROD4 gene

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for NEUROD4 gene

Publications
for NEUROD4 gene

Intellectual Property
for NEUROD4 gene

Products
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