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NEUROD4 Gene

protein-coding   GIFtS: 49
GCID: GC12P055413

Neuronal Differentiation 4

(Previous name: neurogenic differentiation 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal Differentiation 41 2     bHLHa42 3
ATH32 3 5     MATH-32
Neurogenic Differentiation 41 2     Neurogenic Differentiation Factor 42
Class A Basic Helix-Loop-Helix Protein 42 3     ATOH33
Protein Atonal Homolog 32 3     BHLHA43
ATH-32 3     NeuroD43
Atoh32 3     

External Ids:    HGNC: 138021   Entrez Gene: 581582   Ensembl: ENSG000001233077   OMIM: 6116355   UniProtKB: Q9HD903   

Export aliases for NEUROD4 gene to outside databases

Previous GC identifers: GC12P055534 GC12P055130 GC12P053699 GC12P052453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEUROD4 Gene:
NEUROD4 (neuronal differentiation 4) is a protein-coding gene. Diseases associated with NEUROD4 include neuroendocrine tumor, and neuronitis. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90
Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the
regulation of amacrine cell fate specification in the retina (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEUROD4 gene promoter:
         SRF   AP-1   SRF (504 AA)   Olf-1   CUTL1   HNF-1A   c-Ets-1   HNF-1   HSF2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROD4 promoter sequence
   Search Chromatin IP Primers for NEUROD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEUROD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

NEUROD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055413:  view genomic region     (about GC identifiers)

Start:
55,413,729 bp from pter      End:
55,423,801 bp from pter
Size:
10,073 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90 (See protein sequence)
Recommended Name: Neurogenic differentiation factor 4  
Size: 331 amino acids; 37041 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Secondary accessions: B2RAC9

Explore the universe of human proteins at neXtProt for NEUROD4: NX_Q9HD90

Explore proteomics data for NEUROD4 at MOPED

Post-translational modifications: 

  • Serine or threonine phosphorylation within the basic region may regulate neurogenic activity (By similarity)1
  • Modification sites at neXtProt

  • See NEUROD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067014.2  
    ENSEMBL proteins: 
     ENSP00000242994  

    NEUROD4 Human Recombinant Protein Products:

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    Novus Biologicals NEUROD4 Protein
    Novus Biologicals NEUROD4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NEUROD4

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    Abcam antibodies for NEUROD4
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    Search ThermoFisher Antibodies for NEUROD4
    LSBio Antibodies in human, mouse, rat for NEUROD4

    NEUROD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for NEUROD4
    Cloud-Clone Corp. CLIAs for NEUROD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR011598 bHLH_dom
     IPR022575 Neurogenic_DUF
     IPR016637 TF_bHLH_NeuroD

    Graphical View of Domain Structure for InterPro Entry Q9HD90

    ProtoNet protein and cluster: Q9HD90

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NDF4_HUMAN, Q9HD90
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    NEUROD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDF4_HUMAN, Q9HD90
    Function: Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the
    regulation of amacrine cell fate specification in the retina (By similarity)

         Genatlas biochemistry entry for NEUROD4:
    neurogenesis regulator D4,rat homolog

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    NEUROD4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Neurod4):
     behavior/neurological  cellular  growth/size/body  mortality/aging  nervous system 
     vision/eye 

    NEUROD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurod4tm1Kag for NEUROD4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEUROD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEUROD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEUROD4:
    hsa-mir-335-5p (MIRT017092)

    Block miRNA regulation of human, mouse, rat NEUROD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEUROD4 (see all 46):
    hsa-miR-302d hsa-miR-520e hsa-miR-128 hsa-miR-488 hsa-miR-218 hsa-miR-183* hsa-miR-372 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEUROD4
    Predesigned siRNA for gene silencing in human, mouse, rat NEUROD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROD4

    Clone
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    OriGene clones in human, mouse for NEUROD4 (see all 7)
    OriGene ORF clones in mouse, rat for NEUROD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROD4 (NM_021191)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEUROD4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDF4_HUMAN, Q9HD90: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NEUROD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEUROD4
    Interactions:

        Search GeneGlobe Interaction Network for NEUROD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for NEUROD4 (Q9HD903 ENSP000002429944) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNX1T1Q064553, ENSP000002658144I2D: score=1 STRING: ENSP00000265814
    RB1ENSP000002671634STRING: ENSP00000267163
    RBL2ENSP000002621334STRING: ENSP00000262133
    RBL1ENSP000003627684STRING: ENSP00000362768
    CBFA2T2ENSP000002626534STRING: ENSP00000262653
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0007405neuroblast proliferation IEA--

    NEUROD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEUROD4 (NDF4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEUROD4 gene: 
    NM_021191.2  

    Unigene Cluster for NEUROD4:

    Neuronal differentiation 4
    Hs.591024  [show with all ESTs]
    Unigene Representative Sequence: NM_021191
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000242994(uc001sgp.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEUROD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEUROD4 (see all 46):
    hsa-miR-302d hsa-miR-520e hsa-miR-128 hsa-miR-488 hsa-miR-218 hsa-miR-183* hsa-miR-372 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEUROD4
    Predesigned siRNA for gene silencing in human, mouse, rat NEUROD4
    Clone
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    OriGene clones in human, mouse for NEUROD4 (see all 7)
    OriGene ORF clones in mouse, rat for NEUROD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROD4 (NM_021191)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEUROD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEUROD4
      QuantiTect SYBR Green Assays in human, mouse, rat NEUROD4
      QuantiFast Probe-based Assays in human, mouse, rat NEUROD4

    Additional mRNA sequence: 

    AK314136.1 BC040961.1 

    1 DOTS entry:

    DT.97836779 

    22 AceView cDNA sequences:

    BC040961 NM_021191 BX281568 AA679237 BM689505 BM702746 BM683125 BM661495 
    BM450929 BX954802 BM661723 BM669993 AA364606 BM719169 AA179161 BM699332 
    BU729797 AA663038 BM689756 CK301083 AV751104 AA179353 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEUROD4 expression in normal human tissues (normalized intensities)      NEUROD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAAGCCT
    NEUROD4 Expression
    About this image


    NEUROD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Epithalamus
             Septum   
     
     Eye (Sensory Organs)    fully expand to see all 11 entries
             Ganglion Precursor Cells Ganglion Cell Layer
             Retina
             lens   
     
     Neurons
             Ganglion Precursor Cells Ganglion Cell Layer
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Mesencephalic Ventricular Zone
     
     NULL (Uncategorized)
             Neural rosettes
    NEUROD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEUROD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591024
        Custom PCR Arrays for NEUROD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEUROD4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurod41 , 5 neurogenic differentiation 41, 5 87.37(n)1
    88.79(a)1
      10 (77.81 cM)5
    119231  NM_007501.41  NP_031527.11 
     1302681535 
    chicken
    (Gallus gallus)
    Aves NEUROD41 neuronal differentiation 4 73.13(n)
    79.39(a)
      395959  NM_205076.1  NP_990407.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROD46
    neuronal differentiation 4
    78(a)
    1 ↔ 1
    GL343252.1(1154747-1155742)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xath-32 xenopus atonal homolog-3 73.74(n)    D85188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurod42 neurogenic differentiation 4 75.13(n)   266958  AY036624.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cnd-16
    ngn-16
    Protein NGN-1 (ngn-1) mRNA, complete cds
    38(a)
    34(a)
    many ↔ many
    many ↔ many
    III(5240593-5242108) WBGene00000561
    IV(2626132-2628230) WBGene00003595


    ENSEMBL Gene Tree for NEUROD4 (if available)
    TreeFam Gene Tree for NEUROD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEUROD4 gene
    NEUROG32  NEUROD22  NEUROG22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  
    NEUROG12  
    5 SIMAP similar genes for NEUROD4 using alignment to 1 protein entry:     NDF4_HUMAN:
    NEUROD1    ATOH7    NEUROD6    FERD3L    NEUROD2

    NEUROD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEUROD4 (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400056001,2
    C--55411787(+) TGTACA/GCTTGT 1 -- us2k10--------
    rs1472249051,2
    C--55411817(+) CACAT-/ACACACA 1 -- us2k10--------
    rs171168161,2
    C,F,H--55411874(+) CTTACA/GTCTGT 1 -- us2k1 tfbs319Minor allele frequency- G:0.02NA NS EA 1824
    rs1828651791,2
    --55411971(+) ACTCCC/TTGCCC 1 -- us2k10--------
    rs1871904101,2
    --55411991(+) TCACAA/GGCATC 1 -- us2k10--------
    rs758990631,2
    F--55412106(+) TCCTAG/AACATA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1438752181,2
    C--55412200(+) GTTTAA/TTTATT 1 -- us2k10--------
    rs1914998061,2
    C--55412514(+) TTTGAC/TGCATG 1 -- us2k10--------
    rs1163957971,2
    F--55412519(+) CGCATG/CTGCTA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs79610721,2
    C,F,A,H--55412550(+) GATTCT/CCAAAA 1 -- us2k119Minor allele frequency- C:0.04NS EA NA WA 1994

    HapMap Linkage Disequilibrium report for NEUROD4 (55413729 - 55423801 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NEUROD4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEUROD4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611635    OMIM disorders: --

    4 diseases for NEUROD4:    About MalaCards
    neuroendocrine tumor    neuronitis    retinitis    cerebritis


    NEUROD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEUROD4
    Human Genome Epidemiology (HuGE) Navigator: NEUROD4 (2 documents)

    Export disorders for NEUROD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEUROD4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with NEUROD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix- loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY. (PubMed id 11078465)1, 2, 4, 9 Horikawa Y.... Bell G.I. (Diabetes 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58158 HGNC: 13802 AceView: NEUROD4 Ensembl:ENSG00000123307 euGenes: HUgn58158
    ECgene: NEUROD4 H-InvDB: NEUROD4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEUROD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEUROD4 gene:
    Search GeneIP for patents involving NEUROD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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