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NEUROD2 Gene

protein-coding   GIFtS: 57
GCID: GC17M037760

Neuronal Differentiation 2

(Previous name: neurogenic differentiation 2)
  See NEUROD2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal Differentiation 21 2     bHLHa12 3
Neurogenic Differentiation 21 2     Neurogenic Basic-Helix-Loop-Helix Protein2
Class A Basic Helix-Loop-Helix Protein 12 3     Neurogenic Differentiation Factor 22
NeuroD-Related Factor2 3     BHLHA13
NDRF2 3     NeuroD23

External Ids:    HGNC: 77631   Entrez Gene: 47612   Ensembl: ENSG000001715327   OMIM: 6017255   UniProtKB: Q157843   

Export aliases for NEUROD2 gene to outside databases

Previous GC identifers: GC17M037260 GC17M039758 GC17M037670 GC17M038136 GC17M038135 GC17M035014 GC17M033554


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEUROD2 Gene:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression
of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain
a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in
non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of
neuronal cell fates. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEUROD2 Gene:
NEUROD2 (neuronal differentiation 2) is a protein-coding gene. Diseases associated with NEUROD2 include alcohol dependence. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784
Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription
activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic
program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the
presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal
differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of
thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains
within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal
granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates
with chromatin to the DPYSL3 E box-containing promoter (By similarity)

Gene Wiki entry for NEUROD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEUROD2 gene promoter:
         Oct-B1   oct-B2   AP-1   Sp1   NRSF form 1   NRSF form 2   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROD2 promoter sequence
   Search Chromatin IP Primers for NEUROD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEUROD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

NEUROD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037760:  view genomic region     (about GC identifiers)

Start:
37,759,789 bp from pter      End:
37,766,030 bp from pter
Size:
6,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784 (See protein sequence)
Recommended Name: Neurogenic differentiation factor 2  
Size: 382 amino acids; 41361 Da
Subunit: Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription
activation require dimerization with another bHLH protein (By similarity)
Secondary accessions: Q8TBI7 Q9UQC6

Explore the universe of human proteins at neXtProt for NEUROD2: NX_Q15784

Explore proteomics data for NEUROD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEUROD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006151.3  
    ENSEMBL proteins: 
     ENSP00000306754  

    NEUROD2 Human Recombinant Protein Products:

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    antibodies-online proteins for NEUROD2 (5 products) 

     
    antibodies-online peptides for NEUROD2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR011598 bHLH_dom
     IPR022575 Neurogenic_DUF
     IPR016637 TF_bHLH_NeuroD

    Graphical View of Domain Structure for InterPro Entry Q15784

    ProtoNet protein and cluster: Q15784

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784
    Domain: The C-terminus region is necessary for depolarization-induced and calcium-dependent transcription
    activation (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with NEUROD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDF2_HUMAN, Q15784
    Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription
    activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic
    program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the
    presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal
    differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of
    thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains
    within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal
    granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates
    with chromatin to the DPYSL3 E box-containing promoter (By similarity)

         Genatlas biochemistry entry for NEUROD2:
    neurogenesis regulator D2,with transcriptional activity,expressed in the developing nervous system and in adult
    cortex,hippocampus cerebellum

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8816493
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ISS--
         
    Find genes that share ontologies with NEUROD2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NEUROD2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Neurod2):
     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with NEUROD2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NEUROD2

    miRNA
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    miRTarBase miRNAs that target NEUROD2:
    hsa-mir-335-5p (MIRT018380)

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    Selected qRT-PCR Assays for microRNAs that regulate NEUROD2 (see all 70):
    hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-877* hsa-miR-4325 hsa-miR-93 hsa-miR-490-3p hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDF2_HUMAN, Q15784: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with NEUROD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEUROD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEUROD2
    Interactions:

        Search GeneGlobe Interaction Network for NEUROD2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for NEUROD2 (Q157842, 3 ENSP000003067544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8273785 I2D: score=2 
    PKN1Q165123, ENSP000003433254I2D: score=3 STRING: ENSP00000343325
    ID4ENSP000003679724STRING: ENSP00000367972
    EYA1ENSP000003426264STRING: ENSP00000342626
    SIX2ENSP000003045024STRING: ENSP00000304502
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8816493
    GO:0007399nervous system development TAS8816493
    GO:0008306associative learning IEA--

    Find genes that share ontologies with NEUROD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEUROD2 (NDF2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEUROD2 gene: 
    NM_006160.3  

    Unigene Cluster for NEUROD2:

    Neuronal differentiation 2
    Hs.322431  [show with all ESTs]
    Unigene Representative Sequence: NM_006160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580874(uc021tws.1) ENST00000302584(uc002hry.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat NEUROD2 using miScript Target Protectors
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    hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-877* hsa-miR-4325 hsa-miR-93 hsa-miR-490-3p hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat NEUROD2
      QuantiFast Probe-based Assays in human, mouse, rat NEUROD2

    Additional mRNA sequence: 

    BC022481.1 BT019365.1 

    4 DOTS entries:

    DT.70100544  DT.40283976  DT.100638233  DT.95146845 

    22 AceView cDNA sequences:

    CR624963 BI523533 CR590531 BX411357 BC022481 NM_006160 AW157856 BX421002 
    AW950559 CD580053 AW162861 AL538289 AA340177 BI523235 AI815817 BX455717 
    AL536376 AL567239 AI815516 AW163578 AW161404 BX455029 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEUROD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGAGGAGC
    NEUROD2 Expression
    About this image


    NEUROD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
             Human Neurons   
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             superior temporal gyrus   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)
             Telencephalon
    NEUROD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEUROD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.322431
        Custom PCR Arrays for NEUROD2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEUROD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurod21 , 5 neurogenic differentiation 21, 5 92.23(n)1
    98.17(a)1
      11 (61.75 cM)5
    180131  NM_010895.31  NP_035025.31 
     983254155 
    chicken
    (Gallus gallus)
    Aves LOC1008592031 neurogenic differentiation factor 2-like 81.69(n)
    82.25(a)
      100859203  XM_003643420.2  XP_003643468.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEUROD26
    neuronal differentiation 2
    73(a)
    1 ↔ 1
    6(67945294-67946466)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia neurod21 neuronal differentiation 2 70.75(n)
    73.5(a)
      779941  NM_001079018.1  NP_001072486.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF115774.12   -- 72.81(n)   114435  AF115774.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cnd-16
    ngn-16
    Protein NGN-1 (ngn-1) mRNA, complete cds
    35(a)
    33(a)
    many ↔ many
    many ↔ many
    III(5240593-5242108) WBGene00000561
    IV(2626132-2628230) WBGene00003595


    ENSEMBL Gene Tree for NEUROD2 (if available)
    TreeFam Gene Tree for NEUROD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEUROD2 gene
    NEUROG32  NEUROG22  NEUROD12  NEUROD62  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    6 SIMAP similar genes for NEUROD2 using alignment to 1 protein entry:     NDF2_HUMAN:
    ATOH7    TAL2    NEUROD6    NEUROD1    NEUROD4    FERD3L

    Find genes that share paralogs with NEUROD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEUROD2 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827737681,2
    --37759571(+) CCTTAG/TAATGT 1 -- ds50010--------
    rs612685471,2
    C--37759573(+) TGTTT-/TGTTT 
            
    AAAAA
    1 -- ds50010--------
    rs1865962231,2
    --37759586(+) TTTTGC/TTTTGT 1 -- ds50010--------
    rs778458621,2
    C,F--37759667(+) GCAACA/TGTGGG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1477118941,2
    C--37759696(+) TGGCT-/GGTTCC 1 -- ds50010--------
    rs1483814551,2
    --37759857(+) GCCCAA/GTGGGT 1 -- ds50010--------
    rs99108831,2
    C,F,H--37759934(+) CACAGT/CCACTT 1 -- ds50016Minor allele frequency- C:0.02NS NA WA 814
    rs722283131,2
    C--37759977(+) CAAAC-/CTTCTCTC 1 -- ds50010--------
    rs763471341,2
    --37760038(+) TCTCAC/TTTACA 1 -- ut310--------
    rs1508797481,2
    C--37760166(+) GTGTGG/TGTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NEUROD2 (37759789 - 37766030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NEUROD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2047CNV Insertion18451855
    nsv908207CNV Loss21882294
    dgv3163n71CNV Loss21882294
    dgv3164n71CNV Loss21882294
    dgv3162n71CNV Loss21882294
    nsv521294CNV Loss19592680
    dgv40n68CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601725    OMIM disorders: --

    1 disease for NEUROD2:    
    About MalaCards
    alcohol dependence


    Find genes that share disorders with NEUROD2           About GenesLikeMe

    Genetic Association Database (GAD): NEUROD2
    Human Genome Epidemiology (HuGE) Navigator: NEUROD2 (5 documents)

    Export disorders for NEUROD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEUROD2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NEUROD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF). (PubMed id 10209266)1, 2, 9 Kitamura T.... Kawakami H. (Biochim. Biophys. Acta 1999)
    2. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. (PubMed id 17117180)1, 4 Benusiglio P.R....Ponder B.A. (Br. J. Cancer 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. NeuroD/beta2 gene G--&gt;A polymorphism may affect onset pattern of type 1 diabetes in Japanese. (PubMed id 11473083)1, 4 Yamada S....Saruta T. (Diabetes Care 2001)
    7. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PubMed id 9119405)1, 3 Tamimi R.M....Tapscott S.J. (Genomics 1997)
    8. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PubMed id 8816493)1, 2 McCormick M.B....Tapscott S.J. (Mol. Cell. Biol. 1996)
    9. Novel neurodevelopmental information revealed in amniotic fluid supernatant transcripts from fetuses with trisomies 18 and 21. (PubMed id 22752091)1 Hui L....Bianchi D.W. (Hum. Genet. 2012)
    10. Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (PubMed id 20880594)1 Zill P....Soyka M. (Psychiatry Res 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4761 HGNC: 7763 AceView: NEUROD2 Ensembl:ENSG00000171532 euGenes: HUgn4761
    ECgene: NEUROD2 H-InvDB: NEUROD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEUROD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEUROD2 gene:
    Search GeneIP for patents involving NEUROD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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