Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEUROD2 Gene

protein-coding   GIFtS: 59
GCID: GC17M037760

neuronal differentiation 2

(Previous name: neurogenic differentiation 2 )
 Explore 6 diseases affiliated with
NEUROD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NEUROD2    

Aliases
for NEUROD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuronal Differentiation 21 2     NeuroD-Related Factor2 3
NDRF1 2 3     Neurogenic Basic-Helix-Loop-Helix Protein2
BHLHa11     Neurogenic Differentiation Factor 22
Neurogenic Differentiation 21 2     BHLHA13
Class A Basic Helix-Loop-Helix Protein 12 3     NeuroD23

External Ids:    HGNC: 77631   Entrez Gene: 47612   Ensembl: ENSG000001715327   OMIM: 6017255   UniProtKB: Q157843   

Export aliases for NEUROD2 gene to outside databases

Previous GC identifers: GC17M037260 GC17M039758 GC17M037670 GC17M038136 GC17M038135 GC17M035014 GC17M033554


Summaries
for NEUROD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NEUROD2:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of
this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a
specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in
non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal
cell fates. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784
Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription
activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic
program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the
presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal
differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of
thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within
layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons,
neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the
DPYSL3 E box-containing promoter (By similarity)

Gene Wiki entry for NEUROD2


Genomic Views
for NEUROD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEUROD2 gene promoter:
         Oct-B1   oct-B2   AP-1   Sp1   NRSF form 1   NRSF form 2   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEUROD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEUROD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

NEUROD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037760:  view genomic region     (about GC identifiers)

Start:
 37,759,789 bp from pter      End:
 37,766,030 bp from pter
Size:
 6,242 bases      Orientation:
 minus strand

Proteins
for NEUROD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784 (See protein sequence)
Recommended Name: Neurogenic differentiation factor 2  
Size: 382 amino acids; 41361 Da
Subunit: Interacts with TCF3, TCF4 and TCF12. Interacts with CDC20. Efficient DNA-binding and transcription activation
require dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q8TBI7 Q9UQC6

Explore the universe of human proteins at neXtProt for NEUROD2: NX_Q15784

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15784

    • NEUROD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006151.3  
    ENSEMBL proteins: 
     ENSP00000306754  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NEUROD2
    OriGene Protein Over-expression Lysate: NEUROD2
    OriGene Custom Protein Services for NEUROD2 
    GenScript Custom Purified and Recombinant Proteins Services for NEUROD2
    Novus Biologicals NEUROD2 Proteins
    Novus Biologicals NEUROD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEUROD2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--


    NEUROD2 for ontologies           About GeneDecksing



    NEUROD2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROD2
    R&D Systems Antibodies for NEUROD2
    OriGene Antibodies: NEUROD2
    OriGene Custom Antibody Services for NEUROD2 
    GenScript Custom Superior Antibodies Services for NEUROD2
    Novus Biologicals NEUROD2 Antibodies
    Abcam antibodies for NEUROD2 
    Uscn Antibodies for NEUROD2
    Search ThermoFisher Antibodies for NEUROD2

    Assay Products for NEUROD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEUROD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEUROD2

    Protein Domains /
    Families
    for NEUROD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NEUROD2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011598 HLH_dom
     IPR022575 Neurogenic_DUF
     IPR016637 TF_bHLH_NeuroD

    Graphical View of Domain Structure for InterPro Entry Q15784

    ProtoNet protein and cluster: Q15784

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784
    Domain: The C-terminus region is necessary for depolarization-induced and calcium-dependent transcription activation
    (By similarity)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for NEUROD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDF2_HUMAN, Q15784
    Function: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription
    activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic
    program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the
    presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal
    differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of
    thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within
    layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons,
    neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the
    DPYSL3 E box-containing promoter (By similarity)

         Genatlas biochemistry entry for NEUROD2:
    neurogenesis regulator D2,with transcriptional activity,expressed in the developing nervous system and in adult
    cortex,hippocampus cerebellum

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NEUROD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD2
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD2 (see all 70):
    hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-877* hsa-miR-4325 hsa-miR-93 hsa-miR-490-3p hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NEUROD2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROD2 (see all 7)
    OriGene shRNA RFP: NEUROD2
    OriGene siRNA: NEUROD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NEUROD2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEUROD2 (NM_006160)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NEUROD2
    Search LifeMap BioReagents cell lines for NEUROD2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8816493
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity ISS--


    NEUROD2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NEUROD2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Neurod2):
     behavior/neurological  growth/size  mortality/aging  nervous system 

    NEUROD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NEUROD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription factors in neurogenesis
    		Transcription factors in neurogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NEUROD2
        Transcription factors in neurogenesis




    NEUROD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEUROD2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for NEUROD2 (Q157842, 3 ENSP000003067544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8273785 I2D: score=2 
    PKN1Q165123, ENSP000003433254I2D: score=3 STRING: ENSP00000343325
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8816493
    GO:0007399nervous system development TAS8816493
    GO:0008306associative learning IEA--


    NEUROD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NEUROD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEUROD2
    Search CenterWatch for drugs/clinical trials and news about NEUROD2 / NDF2 

    Transcripts
    for NEUROD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NEUROD2 gene: 
    NM_006160.3  

    Unigene Cluster for NEUROD2:

    Neuronal differentiation 2
    Hs.322431  [show with all ESTs]
    Unigene Representative Sequence: NM_006160
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580874(uc021tws.1) ENST00000302584(uc002hry.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NEUROD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEUROD2
    8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate NEUROD2 (see all 70):
    hsa-miR-106a hsa-miR-219-5p hsa-miR-519a hsa-miR-877* hsa-miR-4325 hsa-miR-93 hsa-miR-490-3p hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NEUROD2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROD2 (see all 7)
    OriGene shRNA RFP: NEUROD2
    OriGene siRNA: NEUROD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROD2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEUROD2 (NM_006160)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD2

    Additional cDNA sequence: 

    BC022481.1 BT019365.1 

    4 DOTS entries:

    DT.70100544  DT.40283976  DT.100638233  DT.95146845 

    22 AceView cDNA sequences:

    CR624963 BI523533 CR590531 BC022481 NM_006160 AW157856 BX411357 BX421002 
    AW950559 AW162861 BI523235 AA340177 AI815817 CD580053 AL538289 AL536376 
    BX455717 AL567239 AI815516 AW163578 AW161404 BX455029 

    GeneLoc Exon Structure


    Expression
    for NEUROD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEUROD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACGAGGAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NEUROD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerGlycinergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerLate Immature Amacrine CellsAmacrine, Retina
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NEUROD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEUROD2

    SOURCE GeneReport for Unigene cluster: Hs.322431
        SABiosciences Custom PCR Arrays for NEUROD2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEUROD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD2

    Orthologs
    for NEUROD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NEUROD2 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008592031 neurogenic differentiation factor 2-like 82.44(n)
    83.1(a)    		   100859203  XM_003643420.1  XP_003643468.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NEUROD26
    		 --
    		 69(a)
    		 1 ↔ 1
    		 6(67945294-67946466)
    zebrafish
    (Danio rerio)    		 Actinopterygii AF115774.12   -- 72.81(n)   114435  AF115774.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea cnd-16
    		 Neurogenic differentiation factor 1
    		 32(a)
    		 1 → many
    		 III(5240554-5242069)


    ENSEMBL Gene Tree for NEUROD2 (if available)
    TreeFam Gene Tree for NEUROD2 (if available) 

    Paralogs
    for NEUROD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEUROD2 gene
    NEUROG32  FERD3L2  NEUROD12  NEUROD62  ATOH12  NEUROG22  BHLHA152  PTF1A2  
    ATOH72  NEUROG12  NEUROD42  
    6 SIMAP similar genes for NEUROD2 using alignment to 1 protein entry:     NDF2_HUMAN:
    ATOH7    TAL2    NEUROD6    NEUROD1    NEUROD4    FERD3L

    NEUROD2 for paralogs           About GeneDecksing



    Genomic Variants
    for NEUROD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in NEUROD2 are shown (see all 90)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1827737681,2
    		--37759571(+) CCTTAG/TAATGT 1 -- ds50010--------
    rs1865962231,2
    		--37759586(+) TTTTGC/TTTTGT 1 -- ds50010--------
    rs612685471,2
    		C--37759603(+) TGTTT-/TGTTT 
                AAAAA     		1 -- ds50010--------
    rs778458621,2
    		C,F,--37759667(+) GCAACA/TGTGGG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1477118941,2
    		--37759696(+) TGGCT-/GGTTCC 1 -- ds50010--------
    rs1483814551,2
    		--37759857(+) GCCCAA/GTGGGT 1 -- ds50010--------
    rs99108831,2
    		C,F,H,--37759934(+) CACAGT/CCACTT 1 -- ds50016Minor allele frequency- C:0.02NS NA WA 814
    rs722283131,2
    		C,--37759977(+) CAAAC-/CTTCTCTC 1 -- ds50010--------
    rs763471341,2
    		--37760038(+) TCTCAC/TTTACA 1 -- ut310--------
    rs1508797481,2
    		--37760166(+) GTGTGG/TGTGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NEUROD2 (37759789 - 37766030 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NEUROD2
         1 CNV: 77591

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROD2
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROD2

    Disorders / Diseases
    for NEUROD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NEUROD2 for disorders           About GeneDecksing

    OMIM gene information: 601725    OMIM disorders: --

    6 diseases for NEUROD2:    About MalaCards
    neuronitis    primitive neuroectodermal tumor    neuroectodermal tumors    alcohol dependence
    alcoholism    breast cancer

    Genetic Association Database (GAD): NEUROD2
    Human Genome Epidemiology (HuGE) Navigator: NEUROD2 (5 documents)

    Export disorders for NEUROD2 gene to outside databases

    Publications
    for NEUROD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEUROD2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NEUROD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF). (PubMed id 10209266)1, 2, 9 Kitamura T.... Kawakami H. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. NeuroD/beta2 gene G-->A polymorphism may affect onset pattern of type 1 diabetes in Japanese. (PubMed id 11473083)1, 4 Yamada S....Saruta T. (2001)
    4. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. (PubMed id 9119405)1, 3 Tamimi R.M....Tapscott S.J. (1997)
    5. NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. (PubMed id 8816493)1, 2 McCormick M.B....Tapscott S.J. (1996)
    6. Novel neurodevelopmental information revealed in amnio tic fluid supernatant transcripts from fetuses with trisomies 18 and 21. (PubMed id 22752091)1 Hui L....Bianchi D.W. (2012)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample. (PubMed id 20880594)1 Zill P....Soyka M. (2010)
    9. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1 Mavaddat N....Pharoah P.D. (2009)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1 GratacA^s M....Carracedo A. (2008)

    External Searches for NEUROD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NEUROD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4761 HGNC: 7763 AceView: NEUROD2 Ensembl:ENSG00000171532 euGenes: HUgn4761
    ECgene: NEUROD2 H-InvDB: NEUROD2

    Other Databases showing NEUROD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NEUROD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEUROD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NEUROD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NEUROD2 gene:
    Search GeneIP for patents involving NEUROD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NEUROD2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NEUROD2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NEUROD2 (NeuroD2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NEUROD2   OriGene shRNA RFP for NEUROD2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEUROD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEUROD2  
     OriGene Protein Over-expression Lysate for NEUROD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NEUROD2   OriGene 3'-UTR Clone for NEUROD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEUROD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NEUROD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEUROD2   OriGene Custom Protein Services for NEUROD2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEUROD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEUROD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEUROD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEUROD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEUROD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEUROD2
     GenScript Custom Purified and Recombinant Proteins Services for NEUROD2 GenScript cDNA clones with any tag delivered in your preferred vector for NEUROD2
     GenScript Custom Assay Services for NEUROD2 GenScript Custom Superior Antibodies Services for NEUROD2
     GenScript Custom overexpressing Cell Line Services for NEUROD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEUROD2 promoter
     Search Chromatin IP Primers for NEUROD2
     RT2 qPCR Primer Assay in human, mouse, rat NEUROD2
     Search GNC Networks for NEUROD2
     SABiosciences Custom PCR Arrays for NEUROD2
     Search Tocris compounds for NEUROD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEUROD2 antibodies
     NEUROD2 proteins
     NEUROD2 lysates
     Antibodies for NEUROD2
     See all of Abcam's Antibodies, Kits and Proteins for NEUROD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NEUROD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NEUROD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD2
     SwitchGear 3'UTR luciferase reporter plasmids for NEUROD2
     SwitchGear Promoter luciferase reporter plasmids for NEUROD2
     Search ThermoFisher Antibodies for NEUROD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NEUROD2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4