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NEUROD1 Gene

protein-coding   GIFtS: 62
GCID: GC02M182505

Neuronal Differentiation 1

(Previous name: neurogenic differentiation 1)
(Previous symbol: NEUROD)
  See NEUROD1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal Differentiation 11 2     BHF-12
NEUROD1 2 3     MODY62
Beta-Cell E-Box Transactivator 21 2     Basic Helix-Loop-Helix Transcription Factor2
Neurogenic Helix-Loop-Helix Protein NEUROD1 2     Neurogenic Differentiation Factor 12
Class A Basic Helix-Loop-Helix Protein 32 3     BHLHA33
bHLHa32 3     NeuroD3
Neurogenic Differentiation 11     NeuroD13
BETA22     NIDDM5

External Ids:    HGNC: 77621   Entrez Gene: 47602   Ensembl: ENSG000001629927   OMIM: 6017245   UniProtKB: Q135623   

Export aliases for NEUROD1 gene to outside databases

Previous GC identifers: GC02M180748 GC02M181224 GC02M182743 GC02M182367 GC02M182249 GC02M174397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEUROD1 Gene:
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The
protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific
DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result
in type II diabetes mellitus. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEUROD1 Gene:
NEUROD1 (neuronal differentiation 1) is a protein-coding gene. Diseases associated with NEUROD1 include maturity-onset diabetes of the young, type 6, and diabetes mellitus, noninsulin-dependent. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NEUROG3.

UniProtKB/Swiss-Prot: NDF1_HUMAN, Q13562
Function: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing
promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to
stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor
CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the
formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum
or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine
cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate
specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with
chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By
similarity)

Gene Wiki entry for NEUROD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NEUROD1 gene promoter:
         p300   NRSF form 1   E2F-2   HNF-4alpha2   NRSF form 2   HNF-4alpha1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEUROD1 promoter sequence
   Search Chromatin IP Primers for NEUROD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEUROD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q32

NEUROD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEUROD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M182505:  view genomic region     (about GC identifiers)

Start:
182,537,815 bp from pter      End:
182,545,603 bp from pter
Size:
7,789 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDF1_HUMAN, Q13562 (See protein sequence)
Recommended Name: Neurogenic differentiation factor 1  
Size: 356 amino acids; 39920 Da
Subunit: Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus) (By similarity). Heterodimer
with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Efficient
DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the
interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2
Secondary accessions: B2R9I8 F1T0E1 O00343 Q13340 Q5U095 Q96TH0 Q99455 Q9UEC8

Explore the universe of human proteins at neXtProt for NEUROD1: NX_Q13562

Explore proteomics data for NEUROD1 at MOPED

Post-translational modifications: 

  • Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for
    nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
    Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation
    on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEUROD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002491.2  
    ENSEMBL proteins: 
     ENSP00000295108  
    Reactome Protein details: Q13562

    NEUROD1 Human Recombinant Protein Products:

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    Novus Biologicals NEUROD1 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NEUROD1

     
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    antibodies-online proteins for NEUROD1 (7 products) 

     
    antibodies-online peptides for NEUROD1

    NEUROD1 Antibody Products:

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    antibodies-online antibodies for NEUROD1 (73 products) 

    NEUROD1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NEUROD1
    Cloud-Clone Corp. CLIAs for NEUROD1
    Search eBioscience for ELISAs for NEUROD1 
    antibodies-online kits for NEUROD1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    3 InterPro protein domains:
     IPR011598 bHLH_dom
     IPR022575 Neurogenic_DUF
     IPR016637 TF_bHLH_NeuroD

    Graphical View of Domain Structure for InterPro Entry Q13562

    ProtoNet protein and cluster: Q13562

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: NDF1_HUMAN, Q13562
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with NEUROD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDF1_HUMAN, Q13562
    Function: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing
    promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to
    stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor
    CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the
    formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum
    or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine
    cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate
    specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with
    chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By
    similarity)

         Genatlas biochemistry entry for NEUROD1:
    neurogenesis regulator D1,identical to hamster beta2 gene,expressed in pancreatic beta cells,regulating sequence
    and granule cells in the cerebellum and hippocampus,and involved in their differentiation

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IPI19619559
    GO:0001105RNA polymerase II transcription coactivator activity IDA19619559
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ISS--
    GO:0003690double-stranded DNA binding IEA--
         
    Find genes that share ontologies with NEUROD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NEUROD1:
     Decreased viability with pacli 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Neurod1):
     behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system  renal/urinary system 
     respiratory system  vision/eye 

    Find genes that share phenotypes with NEUROD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Neurod1tm1Mjts for NEUROD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEUROD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEUROD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEUROD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEUROD1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GCCATCTGTT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEUROD1:
    hsa-mir-30a-5p (MIRT007297)

    Block miRNA regulation of human, mouse, rat NEUROD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEUROD1 (see all 74):
    hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-30a hsa-miR-4325 hsa-miR-130b hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidNEUROD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEUROD1
    Predesigned siRNA for gene silencing in human, mouse, rat NEUROD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEUROD1

    Clone
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    OriGene clones in human, mouse for NEUROD1 (see all 8)
    OriGene ORF clones in mouse, rat for NEUROD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEUROD1 (NM_002500)
    Sino Biological Human cDNA Clone for NEUROD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEUROD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEUROD1
    Addgene plasmids for NEUROD1 

    Cell Line
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13884) for NEUROD1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDF1_HUMAN, Q13562: Cytoplasm (By similarity). Nucleus. Note=In pancreatic islet cells, shuttles to the nucleus
    in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA14752053
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NEUROD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEUROD1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Maturity onset diabetes of the young0.61
    Regulation of gene expression in beta cells0.64
    Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells0.00
    2L1CAM interactions
    Developmental Biology0.63
    3Hepatic ABC Transporters
    MODY (Maturity-Onset Diabetes of Young)0.41
    4Type II diabetes mellitus
    Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics0.38
    5Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell


    Find genes that share SuperPaths with NEUROD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NEUROD1
        Transcriptional Regulatory Network in Embryonic Stem Cell
    MODY (Maturity-Onset Diabetes of Young)

    2 Cell Signaling Technology (CST) Pathways for NEUROD1
        Neuroscience
    Glucose / Energy Metabolism

    1 BioSystems Pathway for NEUROD1
        SIDS Susceptibility Pathways


    2 Reactome Pathways for NEUROD1
        Regulation of gene expression in beta cells
    Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

    1 PharmGKB Pathway for NEUROD1
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NEUROD1):
        Maturity onset diabetes of the young

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NEUROD1: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NEUROD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEUROD1 (Q135623 ENSP000002951084) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    MAFAQ8NHW33, ENSP000003283644I2D: score=2 STRING: ENSP00000328364
    HAP1P542573, ENSP000003340024I2D: score=1 STRING: ENSP00000334002
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003326pancreatic A cell fate commitment IEA--
    GO:0003329pancreatic PP cell fate commitment IEA--
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0007263nitric oxide mediated signal transduction IDA17941991
    GO:0009749response to glucose IMP10545951

    Find genes that share ontologies with NEUROD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEUROD1 (NDF1)

    4 Novoseek inferred chemical compound relationships for NEUROD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 26.3 14 12297313 (3), 15793239 (3), 18778246 (2), 15277395 (1) (see all 8)
    retinoic acid 23.2 6 19428697 (1), 15024057 (1), 19885044 (1), 14743441 (1)
    calcium 0 1 16278289 (1)
    corticosterone 0 1 15063783 (1)

    1 PharmGKB related drug/compound annotation for NEUROD1 gene    About this table
    Drug/compound PharmGKB Annotation
    repaglinideCA  



    Find genes that share compounds with NEUROD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEUROD1 gene: 
    NM_002500.4  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496876 ENST00000295108(uc002uof.3 uc021vtn.1)
    miRNA
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    hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-30a hsa-miR-4325 hsa-miR-130b hsa-miR-3065-5p
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13884) for NEUROD1 

    Selected AceView cDNA sequences (see all 99):

    BM559083 BF513405 BQ776704 BU159869 BE783190 BM312193 BM709659 CA950364 
    BQ424891 CA778002 BM353438 BM728742 CA950600 BQ787686 BU730011 BM504712 
    AI280084 BQ272116 BU790031 BQ287811 BU733704 BC009046 CA774889 BU735949 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEUROD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATGCAG
    NEUROD1 Expression
    About this image


    NEUROD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 11 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Pancreatic endoderm/endocrine precursor-like cells
     
     Eye (Sensory Organs)    fully expand to see all 13 entries
             Cone Precursor Cells Outer Nuclear Layer
     
     Neurons
             Cone Precursor Cells Outer Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Epithalamus
             Neural progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Mesencephalic Ventricular Zone
    NEUROD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEUROD1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NEUROD1: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Diabetes in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEUROD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEUROD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurod11 , 5 neurogenic differentiation 11, 5 91.1(n)1
    98.03(a)1
      2 (47.58 cM)5
    180121  NM_010894.21  NP_035024.11 
     794525215 
    chicken
    (Gallus gallus)
    Aves NEUROD11 neurogenic differentiation 1 78.63(n)
    78.53(a)
      395754  NM_204920.1  NP_990251.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia neurod1-A2 neurogenic differentiation 1 78.28(n)    U28067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurod2 neurogenic differentiation 80.1(n)   30169  AF036148.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cnd-16
    ngn-16
    Protein NGN-1 (ngn-1) mRNA, complete cds
    38(a)
    37(a)
    many ↔ many
    many ↔ many
    III(5240593-5242108) WBGene00000561
    IV(2626132-2628230) WBGene00003595


    ENSEMBL Gene Tree for NEUROD1 (if available)
    TreeFam Gene Tree for NEUROD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEUROD1 gene
    NEUROG32  NEUROD22  NEUROG22  NEUROD62  ATOH12  BHLHA152  ATOH72  NEUROG12  
    NEUROD42  
    3 SIMAP similar genes for NEUROD1 using alignment to 2 protein entries:     NDF1_HUMAN (see all proteins):
    NEUROD4    NEUROD6    NEUROD2

    Find genes that share paralogs with NEUROD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEUROD1 (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0124874
    Maturity-onset diabetes of the young 6 (MODY6)4--see VAR_0124872 R L mis40--------
    rs1048936491,2
    Cpathogenic1181931098(-) GGAGCG/TGAACC 2 R L mis10--------
    rs714054631,2
    C--174398433(+) TGCAA-/TTTTT/TTTT
    TT
    /TTTTTTTTT
    TTTTT
    3 -- ut311NA 2
    rs1908592971,2
    --181928362(+) AAATAC/GTGTGT 1 -- ds50010--------
    rs1379800471,2
    --181928369(+) GTGTTC/TTTCAG 1 -- ds50010--------
    rs1826137961,2
    --181928390(+) CCATTA/TTGCTT 1 -- ds50010--------
    rs1852359341,2
    --181928461(+) CTTCTC/TTTGGA 1 -- ds50010--------
    rs120531951,2
    C,F,H--181928524(+) ATTTTT/CCTGGG 1 -- ds500124Minor allele frequency- C:0.10NS EA NA 2745
    rs1410255671,2
    --181928541(+) CTAGTC/TTGCAA 1 -- ds50010--------
    rs1900986191,2
    --181928579(+) TACAGA/GTAACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NEUROD1 (182537815 - 182545603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NEUROD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820203CNV Gain19587683
    nsv834477CNV Gain17160897

    Human Gene Mutation Database (HGMD): NEUROD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEUROD1
    DNA2.0 Custom Variant and Variant Library Synthesis for NEUROD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601724   
    OMIM disorders: 125853  606394  
    UniProtKB/Swiss-Prot: NDF1_HUMAN, Q13562
  • Maturity-onset diabetes of the young 6 (MODY6) [MIM:606394]: A form of diabetes that is characterized by
    an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of
    age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 7 diseases for NEUROD1:    
    About MalaCards
    maturity-onset diabetes of the young, type 6    diabetes mellitus, noninsulin-dependent    maturity-onset diabetes of the young, type 1    monogenic diabetes
    diabetes mellitus    type 1 diabetes mellitus    type 2 diabetes mellitus

    3 diseases from the University of Copenhagen DISEASES database for NEUROD1:
    maturity-onset diabetes of the young     Asthma     Diabetes mellitus

    Find genes that share disorders with NEUROD1           About GenesLikeMe

    7 Novoseek inferred disease relationships for NEUROD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 37.8 1 17761887 (1)
    hyperglycemia 37.5 1 17615265 (1)
    niddm 36.2 1 10545951 (1)
    diabetes mellitus insulin-dependent 29.4 2 15592940 (1), 16909454 (1)
    small cell lung cancer 14.9 1 14533935 (1)
    adenocarcinoma 0 1 14533935 (1)
    tumors 0 7 19307926 (2), 18751955 (1), 20120526 (1), 17549667 (1)

    Genetic Association Database (GAD): NEUROD1
    Human Genome Epidemiology (HuGE) Navigator: NEUROD1 (26 documents)

    Export disorders for NEUROD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEUROD1 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with NEUROD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. (PubMed id 10545951)1, 2, 4, 9 Malecki M.T.... Krolewski A.S. (Nat. Genet. 1999)
    2. The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. (PubMed id 8786144)1, 2, 3 Tamimi R.... Tapscott S.J. (Genomics 1996)
    3. Structure and regulation of the human NeuroD (BETA2/BHF1) gene. (PubMed id 10366743)1, 2, 9 Miyachi T.... Kawakami H. (Brain Res. Mol. Brain Res. 1999)
    4. cDNA cloning and expression analysis of NeuroD mRNA in human retina. (PubMed id 9144558)1, 2, 9 Acharya H.R.... Ahmad I. (Biochem. Biophys. Res. Commun. 1997)
    5. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PubMed id 14752053)1, 2, 9 Kim J.Y.... Choi H.S. (Mol. Endocrinol. 2004)
    6. NeuroD1 gene and interleukin-18 gene polymorphisms in type 1 diabetes in Dalmatian population of Southern Croatia. (PubMed id 16909454)1, 4, 9 Boraska V....Zemunik T. (Croat. Med. J. 2006)
    7. Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis. (PubMed id 15592940)1, 4, 9 Kavvoura F.K. and Ioannidis J.P. (Hum. Genet. 2005)
    8. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. (PubMed id 12482979)1, 2, 9 Ray S.K.... Leiter A.B. (Mol. Cell. Biol. 2003)
    9. The association of Ala45Thr polymorphism in NeuroD with child-onset Type 1a diabetes in Japanese. (PubMed id 11755474)1, 4, 9 Mochizuki M....Nakazawa S. (Diabetes Res. Clin. Pract. 2002)
    10. Retinopathy and nephropathy in type 1 diabetic patients--association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes. (PubMed id 20120526)1, 4, 9 BuA8an K....Znaor L. (Coll Antropol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4760 HGNC: 7762 AceView: NEUROD1 Ensembl:ENSG00000162992 euGenes: HUgn4760
    ECgene: NEUROD1 Kegg: 4760 H-InvDB: NEUROD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEUROD1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=NEUROD1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEUROD1 gene:
    Search GeneIP for patents involving NEUROD1

    Licensable Technologies for NEUROD1 gene:
     Salk Institute: A Molecular Switch Regulating Neurogenesis    (see all 2)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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