NEURL4 Gene
protein-coding GIFtS: 43
GCID: GC17M007218
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neuralized homolog 4 (Drosophila)
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Aliases
for NEURL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuralized Homolog 4 (Drosophila)1 2 | | KIAA17871 3 | | Neuralized-Like Protein 42 |
Export aliases for NEURL4 gene to outside databasesPrevious GC identifers: GC17M007161 GC17M007162 GC17M007113 |
Summaries
for NEURL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEURL4:
The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively splicedtranscript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110,maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers
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Genomic Views
for NEURL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEURL4 gene promoter:
Bach1 AP-1 ATF-2 Nkx2-5 CUTL1 NF-kappaB NF-kappaB2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEURL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13NEURL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M007218: view genomic region
(about GC identifiers)
Start:
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7,218,947 bp from pter |
End:
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7,232,712 bp from pter |
Size:
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13,766 bases |
Orientation:
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minus strand |
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Proteins
for NEURL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8 (See
protein sequence)Recommended Name: Neuralized-like protein 4 Size: 1562 amino acids; 166907 Da
Subunit: Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasomepathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-proteinligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3Amay be indirect and mediated by HERC2
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localizes to procentriole and daughtercentriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis(PubMed:22261722)
Sequence caution: Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Sequence=BAB47416.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for NEURL4:2E63 (3D)
Secondary accessions: Q6GPI8 Q96IU9 Q9H0B0Alternative splicing: 2 isoforms: Q96JN8-1 Q96JN8-2 Explore the universe of human proteins at neXtProt for NEURL4: NX_Q96JN8
Post-translational modifications:
Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JN8
NEURL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001005408.1 NP_115818.2
ENSEMBL proteins: ENSP00000319826 ENSP00000382390 ENSP00000460062 ENSP00000459978 ENSP00000458469
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005814 | centriole |
IEA | -- |
NEURL4 for ontologies About GeneDecksing
NEURL4 Antibody Products:
Assay Products for NEURL4: |
Protein
Domains /
Families
for NEURL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEURL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96JN8ProtoNet protein and cluster: Q96JN8 UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8Domain: The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, butnot for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722)Similarity: Contains 6 NHR (neuralized homology repeat) domains |
Function
for NEURL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110,maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEURL4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4 |
|
Pathways & Interactions
for NEURL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEURL4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/44 Interacting proteins for NEURL4 (Q96JN82, 3 ENSP000003823904) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
|
Drugs & Compounds
for NEURL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NEURL4
Search CenterWatch for drugs/clinical trials and news about NEURL4 / NEUL4
|
Transcripts
for NEURL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NEURL4 gene (2 alternative transcripts): NM_001005408.1 NM_032442.2 Unigene Cluster for NEURL4: Neuralized homolog 4 (Drosophila) Hs.654794 [show with all ESTs]Unigene Representative Sequence: NM_03244213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315614 ENST00000399464(uc002gga.1 uc002ggb.1) ENST00000573186
ENST00000570460 ENST00000572680 ENST00000576794 ENST00000574120 ENST00000571887(uc002ggc.1)
ENST00000572029 ENST00000571508 ENST00000576485 ENST00000576966 ENST00000571243
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEURL4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4 |
Additional cDNA sequence: AB058690.1 AL136870.1 AL833570.1 BC007227.1 BC073134.1 10 DOTS entries: DT.100771686 DT.443650 DT.100825988 DT.121004048 DT.95160643 DT.95160654 DT.92009731 DT.95160641 DT.95160653 DT.214813
GeneLoc Exon Structure
|
Expression
for NEURL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NEURL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTGCTTT
About this image
See NEURL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEURL4
SOURCE GeneReport for Unigene cluster: Hs.654794
UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8Tissue specificity: Widely expressed at high levels (including brain)
SABiosciences Custom PCR Arrays for NEURL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEURL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4 |
Orthologs
for NEURL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NEURL4 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for NEURL4 (if available)
TreeFam Gene Tree for NEURL4 (if available) |
Paralogs
for NEURL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NEURL4 gene
- ENSG000002619152
1 SIMAP similar gene for NEURL4 using alignment to 4 protein entries: NEUL4_HUMAN (see all proteins):GPS2
NEURL4 for paralogs About GeneDecksing
|
Genomic Variants
for NEURL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NEURL4 (7218947 - 7232712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEURL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEURL4 |
|
Disorders
/ Diseases
for NEURL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEURL4 for disorders About GeneDecksing
1  disease for NEURL4: About MalaCardsangelman syndrome
1 disease from the University of Copenhagen DISEASES database for NEURL4:Angelman syndrome Export disorders for NEURL4 gene to outside databases
|
Publications
for NEURL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NEURL4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with NEURL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2, 3 Al-Hakim A.K....Pelletier L. (2012)
- Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)1, 2, 3 Li J....Dynlacht B.D. (2012)
- Identification and proteomic analysis of distinct UBE3 A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G....Howley P.M. (2012)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
|
External Searches for NEURL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEURL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEURL4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NEURL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NEURL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NEURL4 gene:
Search GeneIP for patents involving NEURL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NEURL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NEURL4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEURL4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEURL4 | | | OriGene Protein Over-expression Lysate for NEURL4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NEURL4 | | OriGene 3'-UTR Clone for NEURL4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEURL4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEURL4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL4 |
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 |  |  |  | |
| | | | Search Tocris compounds for NEURL4 |
| |  |  |  |  | | | | |
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 | | | NEURL4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4 |
|  |  |  | | | | Search ThermoFisher Antibodies for NEURL4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4 |
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