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Aliases for NEURL4 Gene

Aliases for NEURL4 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 4 2 3 5
  • Neuralized Homolog 4 (Drosophila) 2
  • KIAA1787 4

External Ids for NEURL4 Gene

Previous GeneCards Identifiers for NEURL4 Gene

  • GC17M007161
  • GC17M007162
  • GC17M007218
  • GC17M007113

Summaries for NEURL4 Gene

Entrez Gene Summary for NEURL4 Gene

  • The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEURL4 Gene

NEURL4 (Neuralized E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. An important paralog of this gene is ENSG00000261915.

UniProtKB/Swiss-Prot for NEURL4 Gene

  • Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

Additional gene information for NEURL4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL4 Gene

Genomics for NEURL4 Gene

GeneHancer (GH) Regulatory Elements for NEURL4 Gene

Promoters and enhancers for NEURL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007328 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 -0.3 -331 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 ZNF207 ENSG00000224647 NEURL4 SNORD10 EIF5A SNORA48 PLSCR3 EIF4A1 DVL2 TP53 KCTD11
GH17I008117 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.3 -791.9 -791874 7.7 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZFP41 SSRP1 HES7 ALOXE3 GC17M008514 TRL-TAG1-1 TRQ-CTG1-5 TRR-TCT2-1 NEURL4 SENP3 NLGN2 DVL2
GH17I007233 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 58 +90.7 90734 11.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DVL2 GABARAP PHF23 CNTROB SNORD10 NEURL4 SNORA48 WRAP53 POLR2A KCTD11
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 49.1 -151.2 -151196 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I008185 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 46.4 -858.9 -858941 5.9 CLOCK MLX ZFP64 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC BORCS6 ENSG00000279152 GC17M008515 GC17M008516 PIR38375 PIR38980 PIR40201 PIR49700 MIR4521 TRI-AAT5-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEURL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEURL4 gene promoter:

Genomic Locations for NEURL4 Gene

Genomic Locations for NEURL4 Gene
chr17:7,315,628-7,329,393
(GRCh38/hg38)
Size:
13,766 bases
Orientation:
Minus strand
chr17:7,218,947-7,232,712
(GRCh37/hg19)

Genomic View for NEURL4 Gene

Genes around NEURL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL4 Gene

Proteins for NEURL4 Gene

  • Protein details for NEURL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JN8-NEUL4_HUMAN
    Recommended name:
    Neuralized-like protein 4
    Protein Accession:
    Q96JN8
    Secondary Accessions:
    • Q6GPI8
    • Q96IU9
    • Q9H0B0

    Protein attributes for NEURL4 Gene

    Size:
    1562 amino acids
    Molecular mass:
    166907 Da
    Quaternary structure:
    • Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.
    SequenceCaution:
    • Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Evidence={ECO:0000305}; Sequence=BAB47416.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEURL4 Gene

    Alternative splice isoforms for NEURL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL4 Gene

Post-translational modifications for NEURL4 Gene

  • Ubiquitinated; undergoes HERC2-dependent Lys-48 ubiquitination. This ubiquitination leads to proteasomal degradation.
  • Ubiquitination at Lys530, Lys841, Lys1232, and isoforms=21415

Other Protein References for NEURL4 Gene

No data available for DME Specific Peptides for NEURL4 Gene

Domains & Families for NEURL4 Gene

Gene Families for NEURL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NEURL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JN8

UniProtKB/Swiss-Prot:

NEUL4_HUMAN :
  • The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).
Domain:
  • The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).
genes like me logo Genes that share domains with NEURL4: view

Function for NEURL4 Gene

Molecular function for NEURL4 Gene

UniProtKB/Swiss-Prot Function:
Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

Phenotypes From GWAS Catalog for NEURL4 Gene

Gene Ontology (GO) - Molecular Function for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22441691
genes like me logo Genes that share ontologies with NEURL4: view
genes like me logo Genes that share phenotypes with NEURL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL4 Gene

Localization for NEURL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269 PubMed:22261722, ECO:0000269 PubMed:22441691}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL4 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NEURL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEURL4 Gene

Pathways & Interactions for NEURL4 Gene

SuperPathways for NEURL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEURL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEURL4 Gene

Drugs & Compounds for NEURL4 Gene

No Compound Related Data Available

Transcripts for NEURL4 Gene

mRNA/cDNA for NEURL4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEURL4 Gene

Neuralized homolog 4 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL4 Gene

No ASD Table

Relevant External Links for NEURL4 Gene

GeneLoc Exon Structure for
NEURL4
ECgene alternative splicing isoforms for
NEURL4

Expression for NEURL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEURL4 Gene

Protein differential expression in normal tissues from HIPED for NEURL4 Gene

This gene is overexpressed in Cerebrospinal fluid (22.6), CD4 Tcells (9.9), Retina (9.2), and Fetal gut (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEURL4 Gene



NURSA nuclear receptor signaling pathways regulating expression of NEURL4 Gene:

NEURL4

SOURCE GeneReport for Unigene cluster for NEURL4 Gene:

Hs.654794

mRNA Expression by UniProt/SwissProt for NEURL4 Gene:

Q96JN8-NEUL4_HUMAN
Tissue specificity: Widely expressed at high levels (including brain).

Evidence on tissue expression from TISSUES for NEURL4 Gene

  • Nervous system(4.3)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with NEURL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL4 Gene

Orthologs for NEURL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
NEURL4 33
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
OneToMany
NEURL4 33
  • 90.69 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
OneToMany
NEURL4 33
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Neurl4 33 16 34
  • 89.01 (n)
rat
(Rattus norvegicus)
Mammalia Neurl4 33
  • 88.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl4 33
  • 66.89 (n)
zebrafish
(Danio rerio)
Actinopterygii neurl4 33 34
  • 67.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta blue 33 34
  • 52.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011965 33
  • 46.59 (n)
Species where no ortholog for NEURL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEURL4 Gene

ENSEMBL:
Gene Tree for NEURL4 (if available)
TreeFam:
Gene Tree for NEURL4 (if available)

Paralogs for NEURL4 Gene

Paralogs for NEURL4 Gene

(2) SIMAP similar genes for NEURL4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NEURL4: view

Variants for NEURL4 Gene

Sequence variations from dbSNP and Humsavar for NEURL4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000208987 -- 7,318,413(-) C/T intron_variant
rs1000263544 -- 7,315,770(-) G/A 3_prime_UTR_variant
rs1000294784 -- 7,320,590(-) T/C intron_variant
rs1000447524 -- 7,321,540(-) C/T intron_variant
rs1000454241 -- 7,315,448(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639865 CNV loss 21293372
esv3639866 CNV gain 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv509650 CNV insertion 20534489
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for NEURL4 Gene

Residual Variation Intolerance Score: 1.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.52; 92.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEURL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL4 Gene

Disorders for NEURL4 Gene

Additional Disease Information for NEURL4

No disorders were found for NEURL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL4 Gene

Publications for NEURL4 Gene

  1. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PMID: 22261722) Al-Hakim AK … Pelletier L (Molecular & cellular proteomics : MCP 2012) 2 3 4 58
  2. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J … Dynlacht BD (EMBO reports 2012) 2 3 4 58
  3. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PMID: 22645313) Martínez-Noël G … Howley PM (Molecular and cellular biology 2012) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NEURL4 Gene

Sources for NEURL4 Gene

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