Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEURL4 Gene

protein-coding   GIFtS: 44
GCID: GC17M007218

Neuralized Homolog 4 (Drosophila)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuralized Homolog 4 (Drosophila)1 2
Neuralized-Like Protein 42
KIAA17873

External Ids:    HGNC: 344101   Entrez Gene: 844612   Ensembl: ENSG000002150417   UniProtKB: Q96JN83   

Export aliases for NEURL4 gene to outside databases

Previous GC identifers: GC17M007161 GC17M007162 GC17M007113


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEURL4 Gene:
The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively
spliced transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEURL4 Gene: 
NEURL4 (neuralized homolog 4 (Drosophila)) is a protein-coding gene. Diseases associated with NEURL4 include angelman syndrome. An important paralog of this gene is NEURL2.

UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of
CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing
centers




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEURL4 gene promoter:
         Bach1   AP-1   ATF-2   Nkx2-5   CUTL1   NF-kappaB   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NEURL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

NEURL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007218:  view genomic region     (about GC identifiers)

Start:
7,218,947 bp from pter      End:
7,232,712 bp from pter
Size:
13,766 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8 (See protein sequence)
Recommended Name: Neuralized-like protein 4  
Size: 1562 amino acids; 166907 Da
Subunit: Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the
proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3
ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A.
Interaction with UBE3A may be indirect and mediated by HERC2
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose
association with centrosomes during mitosis (PubMed:22261722)
Sequence caution: Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Sequence=BAB47416.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for NEURL4:
2E63 (3D)    
Secondary accessions: Q6GPI8 Q96IU9 Q9H0B0
Alternative splicing: 2 isoforms:  Q96JN8-1   Q96JN8-2   

Explore the universe of human proteins at neXtProt for NEURL4: NX_Q96JN8

Explore proteomics data for NEURL4 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal
    degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JN8

  • NEURL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEURL4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005408.1  NP_115818.2  

    ENSEMBL proteins: 
     ENSP00000319826   ENSP00000382390   ENSP00000460062   ENSP00000459978   ENSP00000458469  

    Human Recombinant Protein Products for NEURL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NEURL4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NEURL4
    GenScript Custom Purified and Recombinant Proteins Services for NEURL4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEURL4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IEA--

    NEURL4 for ontologies           About GeneDecksing



    NEURL4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NEURL4
    GenScript Custom Superior Antibodies Services for NEURL4
    Novus Biologicals NEURL4 Antibody
    Abcam antibodies for NEURL4
    Cloud-Clone Corp. Antibodies for NEURL4 
    Search ThermoFisher Antibodies for NEURL4
    Search LSBio for Antibodies for NEURL4 

    Assay Products for NEURL4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEURL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEURL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEURL4 
    Cloud-Clone Corp. CLIAs for NEURL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006573 Neu_Z
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q96JN8

    ProtoNet protein and cluster: Q96JN8

    UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
    Domain: The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1
    restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding,
    but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization
    (PubMed:22261722)
    Similarity: Contains 6 NHR (neuralized homology repeat) domains


    NEURL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUL4_HUMAN, Q96JN8
    Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of
    CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing
    centers

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    NEURL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEURL4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEURL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEURL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEURL4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL4
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL4 (see all 20):
    hsa-miR-4286 hsa-miR-148b hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-650 hsa-miR-218 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNEURL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEURL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEURL4
    Sirion Biotech Customized adenovirus for overexpression of NEURL4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEURL4 (see all 11)
    OriGene ORF clones in mouse, rat for NEURL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NEURL4
    Search LifeMap BioReagents cell lines for NEURL4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEURL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/44 Interacting proteins for NEURL4 (Q96JN82, 3 ENSP000003823904) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCP110O433032MINT-8396480 MINT-8396863 MINT-8396954 MINT-8396999 MINT-8396578 MINT-8396972 MINT-8396494 MINT-8396768 MINT-8396653 MINT-8396896 MINT-8396594 MINT-8396414
    CEP76Q8TAP62, ENSP000002621274MINT-8396653 MINT-8396578 MINT-8396594 MINT-8396494 STRING: ENSP00000262127
    CEP290O150782, ENSP000003080214MINT-8396578 MINT-8396594 MINT-8396494 STRING: ENSP00000308021
    CEP97Q8IW352MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEURL4 (NEUL4)

    Search CenterWatch for drugs/clinical trials and news about NEURL4 / NEUL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEURL4 gene (2 alternative transcripts): 
    NM_001005408.1  NM_032442.2  

    Unigene Cluster for NEURL4:

    Neuralized homolog 4 (Drosophila)
    Hs.654794  [show with all ESTs]
    Unigene Representative Sequence: NM_032442
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315614 ENST00000399464(uc002gga.1 uc002ggb.1) ENST00000573186
    ENST00000570460 ENST00000572680 ENST00000576794 ENST00000574120 ENST00000571887(uc002ggc.1)
    ENST00000572029 ENST00000571508 ENST00000576485 ENST00000576966 ENST00000571243

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL4
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL4 (see all 20):
    hsa-miR-4286 hsa-miR-148b hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-650 hsa-miR-218 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNEURL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEURL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL4
    Clone
    Products:
         
    OriGene clones in human, mouse for NEURL4 (see all 11)
    OriGene ORF clones in mouse, rat for NEURL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL4

    Additional mRNA sequence: 

    AB058690.1 AL136870.1 AL833570.1 BC007227.1 BC073134.1 

    10 DOTS entries:

    DT.100771686  DT.443650  DT.100825988  DT.121004048  DT.95160643  DT.95160654  DT.92009731  DT.95160641 
    DT.95160653  DT.214813 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEURL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGCTTT
    NEURL4 Expression
    About this image


    See NEURL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEURL4

    SOURCE GeneReport for Unigene cluster: Hs.654794

    UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
    Tissue specificity: Widely expressed at high levels (including brain)

        SABiosciences Custom PCR Arrays for NEURL4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEURL4 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurl41 , 5 neuralized homolog 4 (Drosophila)1, 5 89.22(n)1
    95.77(a)1
      11 (42.92 cM)5
    2168601  NM_001013414.21  NP_001013432.11 
     699010725 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    64(a)
    many ↔ many
    many ↔ many
    GL344643.1(393-11448)
    GL344240.1(24870-55924)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5553311 neuralized-like protein 4-like 67.74(n)
    71.99(a)
      555331  XM_677822.5  XP_682914.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta blue1 bluestreak 52.72(n)
    46.91(a)
      39558  NM_140431.2  NP_648688.2 


    ENSEMBL Gene Tree for NEURL4 (if available)
    TreeFam Gene Tree for NEURL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEURL4 gene
    NEURL22  ENSG000002619152  
    2 SIMAP similar genes for NEURL4 using alignment to 4 protein entries:     NEUL4_HUMAN (see all proteins):
    GPS2    NEURL2

    NEURL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/467 SNPs in NEURL4 are shown (see all 467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3725031421,2
    C--7220686(+) AGGCAA/C/GTACCT 6 T S I mis10--------
    rs620591981,2
    C,F--7220697(+) GGGAGG/TAGAAC 2 -- int15Minor allele frequency- T:0.29NA EA EU 1567
    rs755837061,2
    C,F--7220841(+) TGATAT/GGCCAT 4 /A syn13Minor allele frequency- G:0.01WA EU 1443
    rs1447660071,2
    C,F--7220846(+) TGCCAT/CGTGCC 4 /M /V mis11Minor allele frequency- C:0.01EU 1323
    rs346885741,2
    C,F--7220881(+) CCAGGC/TGGGGA 4 H R mis16Minor allele frequency- T:0.04NA EA EU 1569
    rs2015108261,2
    C--7220882(+) CAGGCG/AGGGAT 4 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs80793091,2
    C,F--7220950(+) GGAGGA/GGCTTC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1175585981,2
    F--7220958(+) TTCACG/AAGGCT 2 -- int11Minor allele frequency- A:0.03EA 120
    rs802709901,2
    C,F--7221000(+) TGGCTT/CTTCCT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1901028281,2
    --7221054(+) TCCCCA/GTTTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for NEURL4 (7218947 - 7232712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NEURL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv2665200CNV Deletion23128226
    nsv509650CNV Insertion20534489
    nsv907641CNV Loss21882294
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907642CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NEURL4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEURL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NEURL4:    About MalaCards
    angelman syndrome    

    1 disease from the University of Copenhagen DISEASES database for NEURL4:
    Angelman syndrome

    NEURL4 for disorders           About GeneDecksing


    Export disorders for NEURL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEURL4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NEURL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2, 3 Al-Hakim A.K....Pelletier L. (2012)
    2. Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)1, 2, 3 Li J....Dynlacht B.D. (2012)
    3. Identification and proteomic analysis of distinct UBE3 A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G....Howley P.M. (2012)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    5. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1 Li J.... Dynlacht B.D. (2013)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84461 HGNC: 34410 Ensembl:ENSG00000215041 euGenes: HUgn84461 ECgene: NEURL4
    H-InvDB: NEURL4

    (According to HUGE)
    About This Section
    HUGE: KIAA1787

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEURL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEURL4 gene:
    Search GeneIP for patents involving NEURL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NEURL4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NEURL4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NEURL4  
     OriGene qSTAR qPCR primer pairs in human, mouse for NEURL4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NEURL4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEURL4   OriGene Custom Protein Services for NEURL4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEURL4
     QIAGEN SeqTarget long-range PCR primers for resequencing NEURL4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL4
     GenScript Custom Purified and Recombinant Proteins Services for NEURL4 GenScript cDNA clones with any tag delivered in your preferred vector for NEURL4
     GenScript Custom Assay Services for NEURL4 GenScript Custom Superior Antibodies Services for NEURL4
     GenScript Custom overexpressing Cell Line Services for NEURL4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEURL4 promoter
     Search Chromatin IP Primers for NEURL4
     RT2 qPCR Primer Assay in human, mouse, rat NEURL4
     Search GNC Networks for NEURL4
     SABiosciences Custom PCR Arrays for NEURL4
     Search Tocris compounds for NEURL4 (NEUL4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEURL4 antibodies
     Antibodies for NEURL4
     See all of Abcam's Antibodies, Kits and Proteins for NEURL4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NEURL4
     Antibodies for NEURL4
     ELISAs for NEURL4
     CLIAs for NEURL4
     Search LifeMap BioReagents cell lines for NEURL4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4
     SwitchGear 3'UTR luciferase reporter plasmids for NEURL4
     Browse SwitchGear Promoter luciferase reporter plasmids for NEURL4
     Search ThermoFisher Antibodies for NEURL4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NEURL4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEURL4
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of NEURL4
     Search LSBio for Antibodies for NEURL4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NEURL4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4