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Aliases for NEURL4 Gene

Aliases for NEURL4 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 4 2 3
  • Neuralized Homolog 4 (Drosophila) 2
  • KIAA1787 4

External Ids for NEURL4 Gene

Previous GeneCards Identifiers for NEURL4 Gene

  • GC17M007161
  • GC17M007162
  • GC17M007218
  • GC17M007113

Summaries for NEURL4 Gene

Entrez Gene Summary for NEURL4 Gene

  • The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEURL4 Gene

NEURL4 (Neuralized E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. An important paralog of this gene is NEURL2.

UniProtKB/Swiss-Prot for NEURL4 Gene

  • Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL4 Gene

Genomics for NEURL4 Gene

Regulatory Elements for NEURL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEURL4 Gene

7,315,628 bp from pter
7,329,393 bp from pter
13,766 bases
Minus strand

Genomic View for NEURL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEURL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL4 Gene

Proteins for NEURL4 Gene

  • Protein details for NEURL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuralized-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6GPI8
    • Q96IU9
    • Q9H0B0

    Protein attributes for NEURL4 Gene

    1562 amino acids
    Molecular mass:
    166907 Da
    Quaternary structure:
    • Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.
    • Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Evidence={ECO:0000305}; Sequence=BAB47416.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEURL4 Gene

    Alternative splice isoforms for NEURL4 Gene


neXtProt entry for NEURL4 Gene

Proteomics data for NEURL4 Gene at MOPED

Post-translational modifications for NEURL4 Gene

  • Ubiquitinated; undergoes HERC2-dependent Lys-48 ubiquitination. This ubiquitination leads to proteasomal degradation.
  • Ubiquitination at Lys530, Lys841, Lys1232, and Lys1415
  • Modification sites at PhosphoSitePlus

Other Protein References for NEURL4 Gene

No data available for DME Specific Peptides for NEURL4 Gene

Domains for NEURL4 Gene

Protein Domains for NEURL4 Gene


Suggested Antigen Peptide Sequences for NEURL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96JN8
  • The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).
  • Contains 6 NHR (neuralized homology repeat) domains.
genes like me logo Genes that share domains with NEURL4: view

No data available for Gene Families for NEURL4 Gene

Function for NEURL4 Gene

Molecular function for NEURL4 Gene

UniProtKB/Swiss-Prot Function:
Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

Gene Ontology (GO) - Molecular Function for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22441691
genes like me logo Genes that share ontologies with NEURL4: view

Animal Model Products

miRNA for NEURL4 Gene

miRTarBase miRNAs that target NEURL4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NEURL4 Gene

Localization for NEURL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269 PubMed:22261722, ECO:0000269 PubMed:22441691}.

Subcellular locations from

Jensen Localization Image for NEURL4 Gene COMPARTMENTS Subcellular localization image for NEURL4 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with NEURL4: view

Transcripts for NEURL4 Gene

mRNA/cDNA for NEURL4 Gene

(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEURL4 Gene

Neuralized homolog 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEURL4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL4 Gene

No ASD Table

Relevant External Links for NEURL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEURL4 Gene

mRNA expression in normal human tissues for NEURL4 Gene

Protein differential expression in normal tissues for NEURL4 Gene

This gene is overexpressed in Cerebrospinal fluid (22.6), CD4 Tcells (9.9), Retina (9.2), and Fetal gut (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEURL4 Gene

SOURCE GeneReport for Unigene cluster for NEURL4 Gene Hs.654794

mRNA Expression by UniProt/SwissProt for NEURL4 Gene

Tissue specificity: Widely expressed at high levels (including brain).
genes like me logo Genes that share expressions with NEURL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for NEURL4 Gene

Orthologs for NEURL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NEURL4 35
  • 90.69 (n)
  • 96.36 (a)
-- 36
  • 97 (a)
(Canis familiaris)
Mammalia NEURL4 35
  • 89.8 (n)
  • 95.92 (a)
-- 36
  • 95 (a)
(Mus musculus)
Mammalia Neurl4 35
  • 89.01 (n)
  • 95.46 (a)
Neurl4 16
Neurl4 36
  • 96 (a)
(Pan troglodytes)
Mammalia NEURL4 35
  • 98.59 (n)
  • 98.38 (a)
-- 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Neurl4 35
  • 88.85 (n)
  • 95.45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl4 35
  • 66.89 (n)
  • 69.16 (a)
(Danio rerio)
Actinopterygii neurl4 35
  • 67.02 (n)
  • 70.71 (a)
neurl4 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011965 35
  • 46.59 (n)
  • 36.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta blue 35
  • 52.2 (n)
  • 46.04 (a)
blue 36
  • 32 (a)
Species with no ortholog for NEURL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEURL4 Gene

Gene Tree for NEURL4 (if available)
Gene Tree for NEURL4 (if available)

Paralogs for NEURL4 Gene

Paralogs for NEURL4 Gene

Selected SIMAP similar genes for NEURL4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NEURL4: view

Variants for NEURL4 Gene

Sequence variations from dbSNP and Humsavar for NEURL4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1127440 -- 7,318,066(-) CTTCC(A/C/G/T)GGTGA synonymous-codon, reference
rs2062770 -- 7,323,327(-) GCCCA(C/T)AGGGG intron-variant
rs2062771 -- 7,322,106(-) TTGGC(A/G)TCCCC intron-variant
rs2134509 -- 7,322,261(-) aggat(A/C/T)gct intron-variant
rs2270982 -- 7,323,393(-) TGGGT(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1963 CNV Loss 18451855
nsv907641 CNV Loss 21882294
nsv509650 CNV Insertion 20534489
nsv907642 CNV Loss 21882294

Relevant External Links for NEURL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL4 Gene

Disorders for NEURL4 Gene

(1) University of Copenhagen DISEASES for NEURL4 Gene

genes like me logo Genes that share disorders with NEURL4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for NEURL4 Gene

Publications for NEURL4 Gene

  1. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PMID: 22261722) Al-Hakim A.K. … Pelletier L. (Mol. Cell. Proteomics 2012) 2 3 4
  2. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J. … Dynlacht B.D. (EMBO Rep. 2012) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PMID: 22645313) Martinez-Noel G. … Howley P.M. (Mol. Cell. Biol. 2012) 3 4
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for NEURL4 Gene

Sources for NEURL4 Gene

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