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Aliases for NEURL4 Gene

Aliases for NEURL4 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 4 2 3 5
  • Neuralized Homolog 4 (Drosophila) 2
  • KIAA1787 4

External Ids for NEURL4 Gene

Previous GeneCards Identifiers for NEURL4 Gene

  • GC17M007161
  • GC17M007162
  • GC17M007218
  • GC17M007113

Summaries for NEURL4 Gene

Entrez Gene Summary for NEURL4 Gene

  • The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEURL4 Gene

NEURL4 (Neuralized E3 Ubiquitin Protein Ligase 4) is a Protein Coding gene. An important paralog of this gene is ENSG00000261915.

UniProtKB/Swiss-Prot for NEURL4 Gene

  • Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL4 Gene

Genomics for NEURL4 Gene

Regulatory Elements for NEURL4 Gene

Enhancers for NEURL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008137 1.4 Ensembl ENCODE 29.4 -810.1 -810058 3.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NFYC DVL2 PFAS LOC105371523 SNORD10 CTC1 CNTROB SENP3 SNORA48 NEURL4 KCTD11
GH17F007233 1.2 ENCODE 33.9 +90.7 90713 11.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 DVL2 CNTROB SNORD10 SNORA48 KIAA0753 ELP5 SENP3 MIR6883 NEURL4 ZBTB4
GH17F008149 1.6 FANTOM5 ENCODE 24.1 -827.9 -827926 16.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 DVL2 SENP3 PFAS CTC1 SNORD10 MIR6883 LOC105371523 VAMP2 LOC100996842 NEURL4
GH17F007474 1.6 FANTOM5 ENCODE 22.1 -151.2 -151197 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F008245 1.2 ENCODE 29.4 -918.5 -918538 5.5 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PFAS SENP3 CNTROB CTC1 NEURL4 SNORD10 CYB5D1 SLC25A35 SNORA48 NLGN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEURL4 on UCSC Golden Path with GeneCards custom track

Promoters for NEURL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340165 -307 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 KLF13 ZNF263

Genomic Location for NEURL4 Gene

Chromosome:
17
Start:
7,315,628 bp from pter
End:
7,329,393 bp from pter
Size:
13,766 bases
Orientation:
Minus strand

Genomic View for NEURL4 Gene

Genes around NEURL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL4 Gene

Proteins for NEURL4 Gene

  • Protein details for NEURL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JN8-NEUL4_HUMAN
    Recommended name:
    Neuralized-like protein 4
    Protein Accession:
    Q96JN8
    Secondary Accessions:
    • Q6GPI8
    • Q96IU9
    • Q9H0B0

    Protein attributes for NEURL4 Gene

    Size:
    1562 amino acids
    Molecular mass:
    166907 Da
    Quaternary structure:
    • Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.
    SequenceCaution:
    • Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Evidence={ECO:0000305}; Sequence=BAB47416.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEURL4 Gene

    Alternative splice isoforms for NEURL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL4 Gene

Post-translational modifications for NEURL4 Gene

  • Ubiquitinated; undergoes HERC2-dependent Lys-48 ubiquitination. This ubiquitination leads to proteasomal degradation.
  • Ubiquitination at Lys 530, Lys 841, Lys 1232, and Lys 1415
  • Modification sites at PhosphoSitePlus

Other Protein References for NEURL4 Gene

No data available for DME Specific Peptides for NEURL4 Gene

Domains & Families for NEURL4 Gene

Protein Domains for NEURL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JN8

UniProtKB/Swiss-Prot:

NEUL4_HUMAN :
  • The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).
Domain:
  • The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization (PubMed:22261722).
  • Contains 6 NHR (neuralized homology repeat) domains.
genes like me logo Genes that share domains with NEURL4: view

No data available for Gene Families for NEURL4 Gene

Function for NEURL4 Gene

Molecular function for NEURL4 Gene

UniProtKB/Swiss-Prot Function:
Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

Gene Ontology (GO) - Molecular Function for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22441691
genes like me logo Genes that share ontologies with NEURL4: view
genes like me logo Genes that share phenotypes with NEURL4: view

Animal Model Products

miRNA for NEURL4 Gene

miRTarBase miRNAs that target NEURL4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL4 Gene

Localization for NEURL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269 PubMed:22261722, ECO:0000269 PubMed:22441691}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL4 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NEURL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NEURL4: view

Pathways & Interactions for NEURL4 Gene

SuperPathways for NEURL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEURL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEURL4 Gene

Transcripts for NEURL4 Gene

mRNA/cDNA for NEURL4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEURL4 Gene

Neuralized homolog 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL4 Gene

No ASD Table

Relevant External Links for NEURL4 Gene

GeneLoc Exon Structure for
NEURL4
ECgene alternative splicing isoforms for
NEURL4

Expression for NEURL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEURL4 Gene

Protein differential expression in normal tissues from HIPED for NEURL4 Gene

This gene is overexpressed in Cerebrospinal fluid (22.6), CD4 Tcells (9.9), Retina (9.2), and Fetal gut (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEURL4 Gene



NURSA nuclear receptor signaling pathways regulating expression of NEURL4 Gene:

NEURL4

SOURCE GeneReport for Unigene cluster for NEURL4 Gene:

Hs.654794

mRNA Expression by UniProt/SwissProt for NEURL4 Gene:

Q96JN8-NEUL4_HUMAN
Tissue specificity: Widely expressed at high levels (including brain).
genes like me logo Genes that share expression patterns with NEURL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NEURL4 Gene

Orthologs for NEURL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
NEURL4 34
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
NEURL4 34
  • 90.69 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
NEURL4 34
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Neurl4 34 16 35
  • 89.01 (n)
rat
(Rattus norvegicus)
Mammalia Neurl4 34
  • 88.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl4 34
  • 66.89 (n)
zebrafish
(Danio rerio)
Actinopterygii neurl4 34 35
  • 67.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta blue 34 35
  • 52.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011965 34
  • 46.59 (n)
Species where no ortholog for NEURL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEURL4 Gene

ENSEMBL:
Gene Tree for NEURL4 (if available)
TreeFam:
Gene Tree for NEURL4 (if available)

Paralogs for NEURL4 Gene

Paralogs for NEURL4 Gene

(2) SIMAP similar genes for NEURL4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NEURL4: view

Variants for NEURL4 Gene

Sequence variations from dbSNP and Humsavar for NEURL4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1043779 -- 7,315,924(-) TCCGT(C/T)TGATG upstream-variant-2KB, utr-variant-3-prime
rs1043786 -- 7,315,779(-) TCCCA(A/G)AGGAG upstream-variant-2KB, utr-variant-3-prime
rs1043790 -- 7,315,698(-) CGGAA(A/C/G)ATGGG upstream-variant-2KB, utr-variant-3-prime
rs1043791 -- 7,315,667(-) TGACT(C/T)TGATT upstream-variant-2KB, utr-variant-3-prime
rs1043792 -- 7,315,660(-) GATTT(C/T)TAAGG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NEURL4 Gene

Variant ID Type Subtype PubMed ID
nsv952118 CNV deletion 24416366
nsv574322 CNV loss 21841781
nsv509650 CNV insertion 20534489
nsv457659 CNV loss 19166990
nsv1963 CNV deletion 18451855
esv3639866 CNV gain 21293372
esv3639865 CNV loss 21293372
esv2665200 CNV deletion 23128226
esv2422288 CNV deletion 17116639

Variation tolerance for NEURL4 Gene

Residual Variation Intolerance Score: 1.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.52; 92.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL4 Gene

Disorders for NEURL4 Gene

Relevant External Links for NEURL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEURL4

No disorders were found for NEURL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL4 Gene

Publications for NEURL4 Gene

  1. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PMID: 22261722) Al-Hakim A.K. … Pelletier L. (Mol. Cell. Proteomics 2012) 2 3 4 64
  2. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PMID: 22441691) Li J. … Dynlacht B.D. (EMBO Rep. 2012) 2 3 4 64
  3. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PMID: 22645313) Martinez-Noel G. … Howley P.M. (Mol. Cell. Biol. 2012) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  5. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64

Products for NEURL4 Gene

Sources for NEURL4 Gene

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