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NEURL4 Gene

protein-coding   GIFtS: 46
GCID: GC17M007218

Neuralized E3 Ubiquitin Protein Ligase 4

(Previous name: neuralized homolog 4 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuralized E3 Ubiquitin Protein Ligase 41 2
Neuralized Homolog 4 (Drosophila)1
Neuralized Homolog 42
Neuralized-Like Protein 42
KIAA17873

External Ids:    HGNC: 344101   Entrez Gene: 844612   Ensembl: ENSG000002150417   UniProtKB: Q96JN83   

Export aliases for NEURL4 gene to outside databases

Previous GC identifers: GC17M007161 GC17M007162 GC17M007113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEURL4 Gene:
The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively
spliced transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEURL4 Gene:
NEURL4 (neuralized E3 ubiquitin protein ligase 4) is a protein-coding gene. Diseases associated with NEURL4 include angelman syndrome, and malaria. An important paralog of this gene is NEURL2.

UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of
CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing
centers




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEURL4 gene promoter:
         Bach1   AP-1   ATF-2   Nkx2-5   CUTL1   NF-kappaB   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NEURL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEURL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

NEURL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007218:  view genomic region     (about GC identifiers)

Start:
7,218,947 bp from pter      End:
7,232,712 bp from pter
Size:
13,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8 (See protein sequence)
Recommended Name: Neuralized-like protein 4  
Size: 1562 amino acids; 166907 Da
Subunit: Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the
proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3
ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A.
Interaction with UBE3A may be indirect and mediated by HERC2
Sequence caution: Sequence=AAH07227.1; Type=Frameshift; Positions=1263; Sequence=BAB47416.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for NEURL4:
2E63 (3D)    
Secondary accessions: Q6GPI8 Q96IU9 Q9H0B0
Alternative splicing: 2 isoforms:  Q96JN8-1   Q96JN8-2   

Explore the universe of human proteins at neXtProt for NEURL4: NX_Q96JN8

Explore proteomics data for NEURL4 at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes HERC2-dependent 'Lys-48' ubiquitination. This ubiquitination leads to proteasomal
    degradation1
  • Ubiquitination2 at Lys530, Lys841, Lys1232, Lys1415
  • Modification sites at PhosphoSitePlus

  • See NEURL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005408.1  NP_115818.2  

    ENSEMBL proteins: 
     ENSP00000319826   ENSP00000382390   ENSP00000460062   ENSP00000459978   ENSP00000458469  
     ENSP00000467514  

    NEURL4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NEURL4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NEURL4
    GenScript Custom Purified and Recombinant Proteins Services for NEURL4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEURL4

    NEURL4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NEURL4
    Novus Biologicals NEURL4 Antibody
    Abcam antibodies for NEURL4
    Cloud-Clone Corp. Antibodies for NEURL4
    Search ThermoFisher Antibodies for NEURL4
    Search LSBio for Antibodies for NEURL4

    NEURL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEURL4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEURL4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEURL4
    Cloud-Clone Corp. CLIAs for NEURL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006573 Neu_Z
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q96JN8

    ProtoNet protein and cluster: Q96JN8

    UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
    Domain: The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1
    restricts targeting to daughter centriole (PubMed:22441691). NHR 3 and 4 are required for CCP110/CEP97-binding,
    but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization
    (PubMed:22261722)
    Similarity: Contains 6 NHR (neuralized homology repeat) domains


    NEURL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUL4_HUMAN, Q96JN8
    Function: Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of
    CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing
    centers

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    NEURL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEURL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEURL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEURL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEURL4

    miRNA
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    miRTarBase miRNAs that target NEURL4:
    hsa-mir-18a-3p (MIRT040850), hsa-mir-16-5p (MIRT051170)

    Block miRNA regulation of human, mouse, rat NEURL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEURL4 (see all 20):
    hsa-miR-4286 hsa-miR-148b hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-650 hsa-miR-218 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNEURL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEURL4
    Predesigned siRNA for gene silencing in human, mouse, rat NEURL4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NEURL4

    Clone
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    OriGene clones in human, mouse for NEURL4 (see all 11)
    OriGene ORF clones in mouse, rat for NEURL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NEURL4
    Browse ESI BIO Cell Lines and PureStem Progenitors for NEURL4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEUL4_HUMAN, Q96JN8: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose
    association with centrosomes during mitosis (PubMed:22261722)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IEA--

    NEURL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEURL4
    Interactions:

        Search GeneGlobe Interaction Network for NEURL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NEURL4 (Q96JN81, 2, 3 ENSP000003823904) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCP110O433031, 2EBI-1053406,EBI-1566217 MINT-8396480 MINT-8396863 MINT-8396954 MINT-8396999 MINT-8396578 MINT-8396972 MINT-8396494 MINT-8396768 MINT-8396653 MINT-8396896 MINT-8396594 MINT-8396414
    CEP76Q8TAP62, ENSP000002621274MINT-8396653 MINT-8396578 MINT-8396594 MINT-8396494 STRING: ENSP00000262127
    CEP290O150782, ENSP000003080214MINT-8396578 MINT-8396594 MINT-8396494 STRING: ENSP00000308021
    CEP97Q8IW352MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEURL4 (NEUL4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEURL4 gene (2 alternative transcripts): 
    NM_001005408.1  NM_032442.2  

    Unigene Cluster for NEURL4:

    Neuralized homolog 4 (Drosophila)
    Hs.654794  [show with all ESTs]
    Unigene Representative Sequence: NM_032442
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315614 ENST00000399464(uc002gga.1 uc002ggb.1) ENST00000573186
    ENST00000570460 ENST00000572680 ENST00000576794 ENST00000574120 ENST00000571887(uc002ggc.1)
    ENST00000572029 ENST00000571508 ENST00000573651 ENST00000576485 ENST00000576966
    ENST00000571243
    miRNA
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    Block miRNA regulation of human, mouse, rat NEURL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEURL4 (see all 20):
    hsa-miR-4286 hsa-miR-148b hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-650 hsa-miR-218 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidNEURL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEURL4
    Predesigned siRNA for gene silencing in human, mouse, rat NEURL4
    Clone
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    OriGene clones in human, mouse for NEURL4 (see all 11)
    OriGene ORF clones in mouse, rat for NEURL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEURL4 (NM_001005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEURL4
      QuantiTect SYBR Green Assays in human, mouse, rat NEURL4
      QuantiFast Probe-based Assays in human, mouse, rat NEURL4

    Additional mRNA sequence: 

    AB058690.1 AL136870.1 AL833570.1 BC007227.1 BC073134.1 

    10 DOTS entries:

    DT.100771686  DT.443650  DT.100825988  DT.121004048  DT.95160643  DT.95160654  DT.92009731  DT.95160641 
    DT.95160653  DT.214813 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEURL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGCTTT
    NEURL4 Expression
    About this image

    NEURL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEURL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654794

    UniProtKB/Swiss-Prot: NEUL4_HUMAN, Q96JN8
    Tissue specificity: Widely expressed at high levels (including brain)

        Custom PCR Arrays for NEURL4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEURL4
    QuantiTect SYBR Green Assays in human, mouse, rat NEURL4
    QuantiFast Probe-based Assays in human, mouse, rat NEURL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEURL4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurl41 , 5 neuralized homolog 4 (Drosophila)1, 5 89.01(n)1
    95.46(a)1
      11 (42.92 cM)5
    2168601  NM_001013414.21  NP_001013432.11 
     699010725 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    GL344240.1(24870-55924)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia neurl41 neuralized E3 ubiquitin protein ligase 4 66.89(n)
    69.16(a)
      100036703  NM_001097252.1  NP_001090721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurl41 neuralized homolog 4 (Drosophila) 67.02(n)
    70.71(a)
      555331  XM_677822.6  XP_682914.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta blue1 bluestreak 52.2(n)
    46.04(a)
      39558  NM_140431.3  NP_648688.2 


    ENSEMBL Gene Tree for NEURL4 (if available)
    TreeFam Gene Tree for NEURL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEURL4 gene
    NEURL22  ENSG000002619152  
    2 SIMAP similar genes for NEURL4 using alignment to 5 protein entries:     NEUL4_HUMAN (see all proteins):
    GPS2    NEURL2

    NEURL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEURL4 (see all 467)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3725031421,2
    C--7220686(+) AGGCAA/C/GTACCT 6 T S I mis10--------
    rs620591981,2
    C,F--7220697(+) GGGAGG/TAGAAC 2 -- int15Minor allele frequency- T:0.29NA EA EU 1567
    rs755837061,2
    C,F--7220841(+) TGATAT/GGCCAT 4 /A syn13Minor allele frequency- G:0.01WA EU 1443
    rs1447660071,2
    C,F--7220846(+) TGCCAT/CGTGCC 4 /M /V mis11Minor allele frequency- C:0.01EU 1323
    rs346885741,2
    C,F--7220881(+) CCAGGC/TGGGGA 4 H R mis16Minor allele frequency- T:0.04NA EA EU 1569
    rs2015108261,2
    C--7220882(+) CAGGCG/AGGGAT 4 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs80793091,2
    C,F--7220950(+) GGAGGA/GGCTTC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1175585981,2
    F--7220958(+) TTCACG/AAGGCT 2 -- int11Minor allele frequency- A:0.03EA 120
    rs802709901,2
    C,F--7221000(+) TGGCTT/CTTCCT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1901028281,2
    --7221054(+) TCCCCA/GTTTCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for NEURL4 (7218947 - 7232712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NEURL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv2665200CNV Deletion23128226
    nsv509650CNV Insertion20534489
    nsv907641CNV Loss21882294
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907642CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEURL4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEURL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for NEURL4:    
    About MalaCards
    angelman syndrome    malaria

    1 disease from the University of Copenhagen DISEASES database for NEURL4:
    Angelman syndrome

    NEURL4 for disorders           About GeneDecksing


    Export disorders for NEURL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEURL4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NEURL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2, 3 Al-Hakim A.K.... Pelletier L. (Mol. Cell. Proteomics 2012)
    2. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PubMed id 22441691)1, 2, 3 Li J....Dynlacht B.D. (EMBO Rep. 2012)
    3. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G.... Howley P.M. (Mol. Cell. Biol. 2012)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1 Li J.... Dynlacht B.D. (Nature 2013)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84461 HGNC: 34410 Ensembl:ENSG00000215041 euGenes: HUgn84461 ECgene: NEURL4
    H-InvDB: NEURL4

    (According to HUGE)
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    HUGE: KIAA1787

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEURL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEURL4 gene:
    Search GeneIP for patents involving NEURL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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