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Aliases for NEURL3 Gene

Aliases for NEURL3 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 3 2 3 5
  • Lung-Inducible Neuralized-Related C3CH4 RING Domain Protein 3 4
  • RING-Type E3 Ubiquitin Transferase NEURL3 3 4
  • Neuralized-Like Protein 3 3 4
  • LINCR 3 4
  • Neuralized Homolog 3 (Drosophila) Pseudogene 2
  • E3 Ubiquitin-Protein Ligase NEURL3 3
  • Neuralized Homolog 3 Pseudogene 3
  • EC 4
  • RNF132 3

External Ids for NEURL3 Gene

Previous GeneCards Identifiers for NEURL3 Gene

  • GC02M097163
  • GC02M091124

Summaries for NEURL3 Gene

GeneCards Summary for NEURL3 Gene

NEURL3 (Neuralized E3 Ubiquitin Protein Ligase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot for NEURL3 Gene

  • E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.

Additional gene information for NEURL3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL3 Gene

Genomics for NEURL3 Gene

GeneHancer (GH) Regulatory Elements for NEURL3 Gene

Promoters and enhancers for NEURL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I096504 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.3 2300 1.8 DRAP1 TAF1 SAP130 RFX5 YY1 RELA ZNF335 RFXANK POLR2A CREM NEURL3 ADRA2B GC02P096431
GH02I096508 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 550.8 0.0 -11 0.3 ELF3 PKNOX1 ATF1 RB1 ARID4B SIN3A ZNF2 THRB ZNF48 RAD21 NEURL3 LOC105373496
GH02I096509 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 -1.5 -1455 1 HDGF ARID4B SIN3A ZNF2 ZNF48 ZNF207 ZNF143 FOS ATF7 RUNX3 NEURL3 LOC105373496
GH02I096503 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.8 +4.9 4935 0.4 ZBTB48 NR2F1 IKZF1 ZNF341 EBF1 NEURL3 GC02P096431
GH02I096501 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +6.0 6019 0.6 ELF3 ARID4B DMAP1 THRB RARA SLC30A9 ZNF143 IKZF2 THAP11 RXRA ITPRIPL1 NEURL3 GC02P096431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEURL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEURL3 gene promoter:

Genomic Locations for NEURL3 Gene

Genomic Locations for NEURL3 Gene
10,494 bases
Minus strand

Genomic View for NEURL3 Gene

Genes around NEURL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL3 Gene

Proteins for NEURL3 Gene

  • Protein details for NEURL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase NEURL3
    Protein Accession:

    Protein attributes for NEURL3 Gene

    262 amino acids
    Molecular mass:
    28789 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEURL3 Gene

Post-translational modifications for NEURL3 Gene

No Post-translational modifications

Other Protein References for NEURL3 Gene

No data available for DME Specific Peptides for NEURL3 Gene

Domains & Families for NEURL3 Gene

Gene Families for NEURL3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NEURL3 Gene


Suggested Antigen Peptide Sequences for NEURL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEURL3: view

No data available for UniProtKB/Swiss-Prot for NEURL3 Gene

Function for NEURL3 Gene

Molecular function for NEURL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.

Enzyme Numbers (IUBMB) for NEURL3 Gene

Gene Ontology (GO) - Molecular Function for NEURL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with NEURL3: view

Phenotypes for NEURL3 Gene

GenomeRNAi human phenotypes for NEURL3:
genes like me logo Genes that share phenotypes with NEURL3: view

Animal Model Products

miRNA for NEURL3 Gene

miRTarBase miRNAs that target NEURL3

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL3 Gene

Localization for NEURL3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NEURL3 Gene

Pathways & Interactions for NEURL3 Gene

SuperPathways for NEURL3 Gene

No Data Available

UniProtKB/Swiss-Prot Q96EH8-NEUL3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for NEURL3 Gene

Selected Interacting proteins: Q96EH8-NEUL3_HUMAN for NEURL3 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NEURL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with NEURL3: view

No data available for Pathways by source and SIGNOR curated interactions for NEURL3 Gene

Drugs & Compounds for NEURL3 Gene

No Compound Related Data Available

Transcripts for NEURL3 Gene

Unigene Clusters for NEURL3 Gene

Neuralized homolog 3 (Drosophila) pseudogene:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: - - -

Relevant External Links for NEURL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEURL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEURL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEURL3 Gene

This gene is overexpressed in Pancreas (x15.9), Kidney - Cortex (x6.6), and Minor Salivary Gland (x5.4).

Protein differential expression in normal tissues from HIPED for NEURL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NEURL3 Gene

Protein tissue co-expression partners for NEURL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEURL3 Gene:


SOURCE GeneReport for Unigene cluster for NEURL3 Gene:

genes like me logo Genes that share expression patterns with NEURL3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL3 Gene

Orthologs for NEURL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEURL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC470439 33
  • 99.24 (n)
(Canis familiaris)
Mammalia LOC102152163 33
  • 83.46 (n)
(Bos Taurus)
Mammalia LOC511385 33
  • 82.11 (n)
(Mus musculus)
Mammalia Neurl3 33 16
  • 77.47 (n)
(Rattus norvegicus)
Mammalia Neurl3 33
  • 77.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl3 33
  • 48.63 (n)
Species where no ortholog for NEURL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NEURL3 Gene

Gene Tree for NEURL3 (if available)
Gene Tree for NEURL3 (if available)

Paralogs for NEURL3 Gene

Paralogs for NEURL3 Gene

(2) SIMAP similar genes for NEURL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL3: view

Variants for NEURL3 Gene

Sequence variations from dbSNP and Humsavar for NEURL3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000210496 -- 96,498,095(-) T/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1000238652 -- 96,509,913(-) G/T upstream_transcript_variant
rs1000291548 -- 96,504,321(-) T/C intron_variant
rs1000388226 -- 96,504,052(-) G/T intron_variant
rs1000503627 -- 96,503,415(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL3 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2720413 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv2835 CNV insertion 18451855

Additional Variant Information for NEURL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NEURL3 Gene

Disorders for NEURL3 Gene

Additional Disease Information for NEURL3

No disorders were found for NEURL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL3 Gene

Publications for NEURL3 Gene

  1. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. (PMID: 15936721) Hu Y … Smith JB (Biochemical and biophysical research communications 2005) 2 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models. (PMID: 16113446) Smith JB … Herschman HR (Proceedings of the American Thoracic Society 2004) 22 58

Products for NEURL3 Gene

Sources for NEURL3 Gene

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