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Aliases for NEURL2 Gene

Aliases for NEURL2 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 2 2 3 5
  • C20orf163 3 4
  • Chromosome 20 Open Reading Frame 163 2
  • Neuralized Homolog 2 (Drosophila) 2
  • Neuralized-Like 2 (Drosophila) 2
  • Neuralized-Like Protein 2 3
  • Neuralized Homolog 2 3
  • OZZ-E3 3
  • OZZ 3

External Ids for NEURL2 Gene

Previous HGNC Symbols for NEURL2 Gene

  • C20orf163

Previous GeneCards Identifiers for NEURL2 Gene

  • GC20M045203
  • GC20M043950
  • GC20M044517
  • GC20M041259

Summaries for NEURL2 Gene

Entrez Gene Summary for NEURL2 Gene

  • This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for NEURL2 Gene

NEURL2 (Neuralized E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. An important paralog of this gene is NEURL4.

UniProtKB/Swiss-Prot for NEURL2 Gene

  • Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

Gene Wiki entry for NEURL2 Gene

Additional gene information for NEURL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL2 Gene

Genomics for NEURL2 Gene

Regulatory Elements for NEURL2 Gene

Enhancers for NEURL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H046111 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -220.1 -220090 0 HDGF PKNOX1 TBL1XR1 BMI1 YBX1 ZNF366 ZNF207 ATF7 ETV6 RUNX3 CD40 NCOA5 PCIF1 SLC12A5 SLC12A5-AS1 ZNF663P SYS1 NEURL2 ZNF335 GC20P046113
GH20H045917 1.4 Ensembl ENCODE dbSUPER 11.6 -27.9 -27941 4 ELF3 FOXA2 ARNT ARID4B THRB ZSCAN9 RARA EGR2 THAP11 SMARCA5 WFDC3 NEURL2 CTSA SPATA25 PLTP ZSWIM3 ACOT8 SNX21 TNNC2 UBE2C
GH20H045933 1.4 ENCODE dbSUPER 11.6 -45.0 -45043 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SNX21 SPATA25 PLTP TP53RK WFDC3 FTLP1 RNU6ATAC38P RPL13P2 CCNB1IP1P2 RPL5P2
GH20H045817 1.4 Ensembl ENCODE dbSUPER 10.9 +73.4 73366 1 HDAC1 KLF17 ZEB1 TCF12 ZNF121 GLIS2 ZNF366 SCRT2 RCOR1 ATF7 WFDC3 PLTP NCOA5 ACOT8 ZSWIM3 DNTTIP1 ZSWIM1 NEURL2 SPATA25 CTSA
GH20H045924 1.3 Ensembl ENCODE dbSUPER 11.6 -33.8 -33849 2 ELF3 FOXA2 ARID4B RAD21 RARA ZHX2 CEBPB KAT8 TGIF2 NFIL3 WFDC3 PLTP NEURL2 CTSA SPATA25 SNX21 TNNC2 ZSWIM3 ACOT8 UBE2C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEURL2 on UCSC Golden Path with GeneCards custom track

Promoters for NEURL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137713 287 2001 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1

Genomic Location for NEURL2 Gene

Chromosome:
20
Start:
45,888,472 bp from pter
End:
45,891,287 bp from pter
Size:
2,816 bases
Orientation:
Minus strand

Genomic View for NEURL2 Gene

Genes around NEURL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL2 Gene

Proteins for NEURL2 Gene

  • Protein details for NEURL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR09-NEUL2_HUMAN
    Recommended name:
    Neuralized-like protein 2
    Protein Accession:
    Q9BR09
    Secondary Accessions:
    • Q3KR34

    Protein attributes for NEURL2 Gene

    Size:
    285 amino acids
    Molecular mass:
    31690 Da
    Quaternary structure:
    • Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of ELOB/Elongin B, ELOC/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1 (By similarity).

neXtProt entry for NEURL2 Gene

Post-translational modifications for NEURL2 Gene

No Post-translational modifications

Other Protein References for NEURL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEURL2 Gene

Domains & Families for NEURL2 Gene

Gene Families for NEURL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NEURL2 Gene

Suggested Antigen Peptide Sequences for NEURL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BR09

UniProtKB/Swiss-Prot:

NEUL2_HUMAN :
  • The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.
Domain:
  • The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.
genes like me logo Genes that share domains with NEURL2: view

Function for NEURL2 Gene

Molecular function for NEURL2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

Phenotypes From GWAS Catalog for NEURL2 Gene

genes like me logo Genes that share phenotypes with NEURL2: view

Animal Models for NEURL2 Gene

MGI Knock Outs for NEURL2:

Animal Model Products

CRISPR Products

miRNA for NEURL2 Gene

miRTarBase miRNAs that target NEURL2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEURL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEURL2 Gene

Localization for NEURL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL2 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NEURL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEURL2: view

Pathways & Interactions for NEURL2 Gene

SuperPathways for NEURL2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BR09-NEUL2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for NEURL2 Gene

Gene Ontology (GO) - Biological Process for NEURL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with NEURL2: view

No data available for Pathways by source and SIGNOR curated interactions for NEURL2 Gene

Drugs & Compounds for NEURL2 Gene

No Compound Related Data Available

Transcripts for NEURL2 Gene

mRNA/cDNA for NEURL2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEURL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL2 Gene

No ASD Table

Relevant External Links for NEURL2 Gene

GeneLoc Exon Structure for
NEURL2
ECgene alternative splicing isoforms for
NEURL2

Expression for NEURL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEURL2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEURL2 Gene



Protein tissue co-expression partners for NEURL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEURL2 Gene:

NEURL2

mRNA Expression by UniProt/SwissProt for NEURL2 Gene:

Q9BR09-NEUL2_HUMAN
Tissue specificity: Expressed specifically in skeletal and cardiac muscles.

Evidence on tissue expression from TISSUES for NEURL2 Gene

  • Muscle(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NEURL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL2 Gene

Orthologs for NEURL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEURL2 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia NEURL2 33 34
  • 90.76 (n)
cow
(Bos Taurus)
Mammalia NEURL2 33 34
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia NEURL2 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurl2 33 16 34
  • 84.68 (n)
rat
(Rattus norvegicus)
Mammalia Neurl2 33
  • 84.56 (n)
chicken
(Gallus gallus)
Aves NEURL2 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEURL2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494896 33
  • 63.32 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162187 33
  • 61.28 (n)
NEURL2 34
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009070 33
  • 56.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3894 33 34
  • 53.23 (n)
Species where no ortholog for NEURL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEURL2 Gene

ENSEMBL:
Gene Tree for NEURL2 (if available)
TreeFam:
Gene Tree for NEURL2 (if available)

Paralogs for NEURL2 Gene

Paralogs for NEURL2 Gene

(1) SIMAP similar genes for NEURL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEURL2: view

Variants for NEURL2 Gene

Sequence variations from dbSNP and Humsavar for NEURL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs137854541 Pathogenic 45,891,714(+) CCGCC(A/G)GTACT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs137854542 Pathogenic 45,891,990(+) CAGCT(C/T)ACTAG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs137854545 Pathogenic 45,892,434(+) CTGGG(A/G)TGGGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs28934603 Pathogenic 45,891,761(+) ACTAC(C/T)GGTCT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs587779402 Pathogenic 45,891,951(+) CAGCC(-/C)TGTGG nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL2 Gene

Variant ID Type Subtype PubMed ID
nsv482069 CNV gain 20164927
nsv517296 CNV loss 19592680
nsv833990 CNV loss 17160897
nsv833991 CNV loss 17160897

Variation tolerance for NEURL2 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL2 Gene

Disorders for NEURL2 Gene

Relevant External Links for NEURL2

Genetic Association Database (GAD)
NEURL2
Human Genome Epidemiology (HuGE) Navigator
NEURL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEURL2

No disorders were found for NEURL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL2 Gene

Publications for NEURL2 Gene

  1. Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. (PMID: 19723503) Rullinkov G … Timmusk T (Biochemical and biophysical research communications 2009) 2 3 60
  2. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S … Nigro V (Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 2008) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. (PMID: 14960280) Nastasi T … D'Azzo A (Developmental cell 2004) 3 4 60

Products for NEURL2 Gene

Sources for NEURL2 Gene

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