Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEURL2 Gene

Aliases for NEURL2 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 2 2 3
  • C20orf163 3 4
  • Chromosome 20 Open Reading Frame 163 2
  • Neuralized Homolog 2 (Drosophila) 2
  • Neuralized-Like 2 (Drosophila) 2
  • Neuralized-Like Protein 2 3
  • Neuralized Homolog 2 3
  • OZZ-E3 3
  • OZZ 3

External Ids for NEURL2 Gene

Previous HGNC Symbols for NEURL2 Gene

  • C20orf163

Previous GeneCards Identifiers for NEURL2 Gene

  • GC20M045203
  • GC20M043950
  • GC20M044517
  • GC20M041259

Summaries for NEURL2 Gene

Entrez Gene Summary for NEURL2 Gene

  • This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for NEURL2 Gene

NEURL2 (Neuralized E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. An important paralog of this gene is NEURL4.

UniProtKB/Swiss-Prot for NEURL2 Gene

  • Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

Gene Wiki entry for NEURL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL2 Gene

Genomics for NEURL2 Gene

Regulatory Elements for NEURL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEURL2 Gene

Start:
45,888,472 bp from pter
End:
45,891,287 bp from pter
Size:
2,816 bases
Orientation:
Minus strand

Genomic View for NEURL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEURL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL2 Gene

Proteins for NEURL2 Gene

  • Protein details for NEURL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR09-NEUL2_HUMAN
    Recommended name:
    Neuralized-like protein 2
    Protein Accession:
    Q9BR09
    Secondary Accessions:
    • Q3KR34

    Protein attributes for NEURL2 Gene

    Size:
    285 amino acids
    Molecular mass:
    31690 Da
    Quaternary structure:
    • Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of TCEB2/Elongin B, TCEB1/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1 (By similarity).

neXtProt entry for NEURL2 Gene

Proteomics data for NEURL2 Gene at MOPED

Post-translational modifications for NEURL2 Gene

No Post-translational modifications

Other Protein References for NEURL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEURL2 Gene

Domains for NEURL2 Gene

Protein Domains for NEURL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BR09

UniProtKB/Swiss-Prot:

NEUL2_HUMAN :
  • Q9BR09
Domain:
  • The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding.
  • Contains 1 NHR (neuralized homology repeat) domain.
  • Contains 1 SOCS box domain.
genes like me logo Genes that share domains with NEURL2: view

No data available for Gene Families for NEURL2 Gene

Function for NEURL2 Gene

Molecular function for NEURL2 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

Gene Ontology (GO) - Molecular Function for NEURL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NEURL2: view

Phenotypes for NEURL2 Gene

genes like me logo Genes that share phenotypes with NEURL2: view

Animal Models for NEURL2 Gene

MGI Knock Outs for NEURL2:

Animal Model Products

miRNA for NEURL2 Gene

miRTarBase miRNAs that target NEURL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEURL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NEURL2 Gene

Localization for NEURL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEURL2 Gene COMPARTMENTS Subcellular localization image for NEURL2 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for NEURL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005927 muscle tendon junction IEA --
GO:0030891 VCB complex IEA --
genes like me logo Genes that share ontologies with NEURL2: view

Pathways for NEURL2 Gene

SuperPathways for NEURL2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BR09-NEUL2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for NEURL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030239 myofibril assembly --
GO:0035556 intracellular signal transduction IEA --
GO:0045214 sarcomere organization IEA --
genes like me logo Genes that share ontologies with NEURL2: view

No data available for Pathways by source for NEURL2 Gene

Transcripts for NEURL2 Gene

mRNA/cDNA for NEURL2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEURL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NEURL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL2 Gene

No ASD Table

Relevant External Links for NEURL2 Gene

GeneLoc Exon Structure for
NEURL2
ECgene alternative splicing isoforms for
NEURL2

Expression for NEURL2 Gene

mRNA expression in normal human tissues for NEURL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEURL2 Gene

mRNA Expression by UniProt/SwissProt for NEURL2 Gene

Q9BR09-NEUL2_HUMAN
Tissue specificity: Expressed specifically in skeletal and cardiac muscles.
genes like me logo Genes that share expressions with NEURL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NEURL2 Gene

Orthologs for NEURL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEURL2 35
  • 99.65 (n)
  • 99.65 (a)
NEURL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEURL2 35
  • 88.89 (n)
  • 93.68 (a)
NEURL2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEURL2 35
  • 90.76 (n)
  • 93.33 (a)
NEURL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurl2 35
  • 84.68 (n)
  • 90.53 (a)
Neurl2 16
Neurl2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEURL2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurl2 35
  • 84.56 (n)
  • 90.18 (a)
chicken
(Gallus gallus)
Aves NEURL2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEURL2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494896 35
  • 63.32 (n)
  • 68.73 (a)
zebrafish
(Danio rerio)
Actinopterygii NEURL2 36
  • 61 (a)
OneToOne
zgc:162187 35
  • 61.28 (n)
  • 64.23 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009070 35
  • 56.04 (n)
  • 45.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3894 35
  • 53.23 (n)
  • 41.53 (a)
CG3894 36
  • 32 (a)
OneToOne
Species with no ortholog for NEURL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEURL2 Gene

ENSEMBL:
Gene Tree for NEURL2 (if available)
TreeFam:
Gene Tree for NEURL2 (if available)

Paralogs for NEURL2 Gene

Paralogs for NEURL2 Gene

Selected SIMAP similar genes for NEURL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEURL2: view

Variants for NEURL2 Gene

Sequence variations from dbSNP and Humsavar for NEURL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_052033 -

Structural Variations from Database of Genomic Variants (DGV) for NEURL2 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
nsv517296 CNV Loss 19592680
nsv833991 CNV Loss 17160897
nsv482069 CNV Gain 20164927

Relevant External Links for NEURL2 Gene

HapMap Linkage Disequilibrium report
NEURL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL2 Gene

Disorders for NEURL2 Gene

Relevant External Links for NEURL2

Genetic Association Database (GAD)
NEURL2
Human Genome Epidemiology (HuGE) Navigator
NEURL2
genes like me logo Genes that share disorders with NEURL2: view

No data available for UniProtKB/Swiss-Prot for NEURL2 Gene

Publications for NEURL2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. (PMID: 14960280) Nastasi T. … D'Azzo A. (Dev. Cell 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NEURL2 Gene

Sources for NEURL2 Gene

Back to Top

Content