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NEURL1B Gene

protein-coding   GIFtS: 44
GCID: GC05P172068

Neuralized E3 Ubiquitin Protein Ligase 1B

(Previous name: neuralized homolog 1B (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuralized E3 Ubiquitin Protein Ligase 1B1 2     neur22
Neuralized-Like Protein 1B2 3     Neuralized 2 Alternative Protein2
Neuralized-Like Protein 32 3     Neuralized Homolog 1B2
NEURL32 3     neuralized-22
Neuralized Homolog 1B (Drosophila)1     EC 6.3.2.-3
E3 Ubiquitin-Protein Ligase NEURL1B2     NEUR23
E3 Ubiquitin-Protein Ligase NEURL32     Neuralized-23
hNeur22     

External Ids:    HGNC: 354221   Entrez Gene: 544922   Ensembl: ENSG000002143577   UniProtKB: A8MQ273   

Export aliases for NEURL1B gene to outside databases

Previous GC identifers: GC05P172002 GC05P167163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEURL1B Gene:
NEURL1B (neuralized E3 ubiquitin protein ligase 1B) is a protein-coding gene. Diseases associated with NEURL1B include malaria, and prostatitis. GO annotations related to this gene include ligase activity. An important paralog of this gene is NEURL1.

UniProtKB/Swiss-Prot: NEU1B_HUMAN, A8MQ27
Function: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the
stability and activity of several Notch ligands




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEURL1B gene promoter:
         Pax-5   CUTL1   Meis-1b   HEN1   AREB6   SRY   STAT3   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NEURL1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEURL1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

NEURL1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P172068:  view genomic region     (about GC identifiers)

Start:
172,068,269 bp from pter      End:
172,118,543 bp from pter
Size:
50,275 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NEU1B_HUMAN, A8MQ27 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NEURL1B  
Size: 555 amino acids; 59270 Da
Subunit: Interacts with JAG1, DLL1 and DLL4
Secondary accessions: C9DQJ5 C9DQJ6 C9DQJ7
Alternative splicing: 3 isoforms:  A8MQ27-1   A8MQ27-2   A8MQ27-3   

Explore the universe of human proteins at neXtProt for NEURL1B: NX_A8MQ27

Explore proteomics data for NEURL1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEURL1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001136123.1  
    ENSEMBL proteins: 
     ENSP00000429797   ENSP00000430001   ENSP00000358815  
    Reactome Protein details: A8MQ27

    NEURL1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for NEURL1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NEURL1B
    GenScript Custom Purified and Recombinant Proteins Services for NEURL1B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEURL1B

    NEURL1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NEURL1B Antibody
    Abcam antibodies for NEURL1B
    Cloud-Clone Corp. Antibodies for NEURL1B
    ThermoFisher Antibody for NEURL1B
    LSBio Antibodies in human, mouse, rat for NEURL1B

    NEURL1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEURL1B
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    GenScript Custom Assay Services for NEURL1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEURL1B
    Cloud-Clone Corp. CLIAs for NEURL1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR006573 Neu_Z
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry A8MQ27

    ProtoNet protein and cluster: A8MQ27

    UniProtKB/Swiss-Prot: NEU1B_HUMAN, A8MQ27
    Similarity: Contains 2 NHR (neuralized homology repeat) domains
    Similarity: Contains 1 RING-type zinc finger


    NEURL1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEU1B_HUMAN, A8MQ27
    Function: E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the
    stability and activity of several Notch ligands

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    NEURL1B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEURL1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEURL1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEURL1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEURL1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEURL1B:
    hsa-mir-335-5p (MIRT018320)

    Block miRNA regulation of human, mouse, rat NEURL1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEURL1B (see all 104):
    hsa-miR-3678-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-15a hsa-miR-1224-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEURL1B
    Predesigned siRNA for gene silencing in human, mouse, rat NEURL1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEURL1B

    Clone
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    OriGene clones in human, mouse for NEURL1B (see all 5)
    OriGene ORF clones in mouse, rat for NEURL1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEURL1B (NM_001142651)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL1B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEURL1B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEU1B_HUMAN, A8MQ27: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    NEURL1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEURL1B About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    2Signaling by NOTCH2
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.67
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    Signaling by NOTCH20.67
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 Reactome Pathways for NEURL1B
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH2 Activation and Transmission of Signal to the Nucleus
    Constitutive Signaling by NOTCH1 HD Domain Mutants
    Activated NOTCH1 Transmits Signal to the Nucleus
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    UniProtKB/Swiss-Prot: NEU1B_HUMAN, A8MQ27
    Pathway: Protein modification; protein ubiquitination


    NEURL1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEURL1B
    Interactions:

        Search GeneGlobe Interaction Network for NEURL1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEURL1B (A8MQ273 ENSP000003588154) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOTCH2Q047213, ENSP000002566464I2D: score=1 STRING: ENSP00000256646
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    DLL1O005483, ENSP000003557184I2D: score=2 STRING: ENSP00000355718
    SSBP054553I2D: score=3 
    JAG2Q9Y2193I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--

    NEURL1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEURL1B (NEU1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEURL1B gene: 
    NM_001142651.1  

    Unigene Cluster for NEURL1B:

    Neuralized homolog 1B (Drosophila)
    Hs.91521  [show with all ESTs]
    Unigene Representative Sequence: NM_001142651
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520919 ENST00000522853 ENST00000369800(uc003mbt.3 uc021yhs.1 uc021yht.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEURL1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEURL1B (see all 104):
    hsa-miR-3678-3p hsa-miR-3607-3p hsa-miR-106a hsa-miR-15a hsa-miR-1224-3p hsa-miR-128 hsa-miR-30d hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEURL1B
    Predesigned siRNA for gene silencing in human, mouse, rat NEURL1B
    Clone
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    OriGene clones in human, mouse for NEURL1B (see all 5)
    OriGene ORF clones in mouse, rat for NEURL1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEURL1B (NM_001142651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEURL1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEURL1B
      QuantiTect SYBR Green Assays in human, mouse, rat NEURL1B
      QuantiFast Probe-based Assays in human, mouse, rat NEURL1B

    Additional mRNA sequence: 

    AK026748.1 AK091605.1 AK096661.1 AK126311.1 AL137347.1 GQ414757.1 GQ414758.1 GQ414759.1 

    5 DOTS entries:

    DT.115529  DT.91966891  DT.100755393  DT.120796631  DT.75104332 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEURL1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCTTTTT
    NEURL1B Expression
    About this image


    NEURL1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    NEURL1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEURL1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91521

    UniProtKB/Swiss-Prot: NEU1B_HUMAN, A8MQ27
    Tissue specificity: Highest expression in brain, prostate and small intestine. In the brain the levels are higher
    in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system,
    cerebellar cortex, optic nerve and the frontal lobe

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    QuantiFast Probe-based Assays in human, mouse, rat NEURL1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEURL1B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurl1b1 , 5 neuralized homolog 1b (Drosophila)1, 5 86.81(n)1
    92.31(a)1
      17 (13.18 cM)5
    2400551  NM_001081656.21  NP_001075125.11 
     264148295 
    chicken
    (Gallus gallus)
    Aves NEURL1B1 neuralized homolog 1B (Drosophila) 70.36(n)
    70.42(a)
      427626  XM_425198.4  XP_425198.2 
    lizard
    (Anolis carolinensis)
    Reptilia NEURL1B6
    neuralized E3 ubiquitin protein ligase 1B
    62(a)
    1 ↔ 1
    2(123983539-123996086)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia neurl1b1 neuralized homolog 1B (Drosophila) 62.23(n)
    67.15(a)
      100496809  XM_002941547.2  XP_002941593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurl1b6
    neuralized homolog 1B (Drosophila)
    60(a)
    1 ↔ 1
    14(19564437-19599512) ENSDARG00000029452
    fruit fly
    (Drosophila melanogaster)
    Insecta neur1 neuralized 49.02(n)
    36.03(a)
      41085  NM_169257.2  NP_731311.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.51 F10D7.5 44.58(n)
    38.46(a)
      181767  NM_078417.5  NP_510818.3 


    ENSEMBL Gene Tree for NEURL1B (if available)
    TreeFam Gene Tree for NEURL1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEURL1B gene
    NEURL12  
    3 SIMAP similar genes for NEURL1B using alignment to 1 protein entry:     NEU1B_HUMAN:
    NEURL3    MDM2    NEURL1

    NEURL1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NEURL1B
    PGOHUM00000250440


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEURL1B (see all 839)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77268331,2
    C--172066288(+) TCATTT/CGCTGC 1 -- us2k14Minor allele frequency- C:0.12NA WA EA 360
    rs77072751,2
    C--172066349(+) aaagtA/Ggcctt 1 -- us2k10--------
    rs751432871,2
    C,F--172066357(+) CTTTAA/TAAGGC 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1814574291,2
    --172066505(+) ATCAGC/TCAGGT 1 -- us2k10--------
    rs119563321,2
    H--172066553(+) gctgaA/Ggtggg 1 -- us2k10--------
    rs1862844791,2
    --172066640(+) ATTAGC/TGGGGC 1 -- us2k10--------
    rs77114861,2
    C,A--172066641(+) ttagcC/Ggggcg 1 -- us2k10--------
    rs602725491,2
    C,F--172066709(+) GAACTC/TGGTAG 1 -- us2k13Minor allele frequency- T:0.25WA CSA 4
    rs1406260831,2
    C--172066785(+) GTCTC-/AAAAAA 1 -- us2k10--------
    rs583726751,2
    C--172066794(+) AAAAA-/GAGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEURL1B (172068269 - 172118543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NEURL1B (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883108CNV Loss21882294
    nsv462526CNV Loss19166990
    nsv522263CNV Loss19592680
    nsv471055CNV Gain18288195
    dgv208e55CNV Gain17911159
    dgv729n27CNV Gain19166990
    esv34432CNV Gain17911159
    nsv523045CNV Gain19592680
    nsv818392CNV Gain17921354
    essv10497CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEURL1B
    DNA2.0 Custom Variant and Variant Library Synthesis for NEURL1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    2 diseases for NEURL1B:    
    About MalaCards
    malaria    prostatitis


    NEURL1B for disorders           About GeneDecksing


    Export disorders for NEURL1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEURL1B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NEURL1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands. (PubMed id 19723503)1, 2 Rullinkov G....Timmusk T. (Biochem. Biophys. Res. Commun. 2009)
    2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. (PubMed id 17003037)1, 3 Song R....Kong Y.Y. (J. Biol. Chem. 2006)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54492 HGNC: 35422 Ensembl:ENSG00000214357 euGenes: HUgn54492 ECgene: NEURL1B
    H-InvDB: NEURL1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEURL1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEURL1B gene:
    Search GeneIP for patents involving NEURL1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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