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Aliases for NEURL1B Gene

Aliases for NEURL1B Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1B 2 3 5
  • Neuralized-Like Protein 1B 3 4
  • Neuralized-Like Protein 3 3 4
  • Neuralized-2 3 4
  • NEURL3 3 4
  • Neur2 3 4
  • E3 Ubiquitin-Protein Ligase NEURL1B 3
  • Neuralized Homolog 1B (Drosophila) 2
  • E3 Ubiquitin-Protein Ligase NEURL3 3
  • Neuralized 2 Alternative Protein 3
  • Neuralized Homolog 1B 3
  • EC 6.3.2.- 4
  • HNeur2 3

External Ids for NEURL1B Gene

Previous GeneCards Identifiers for NEURL1B Gene

  • GC05P172002
  • GC05P167163
  • GC05P172068

Summaries for NEURL1B Gene

GeneCards Summary for NEURL1B Gene

NEURL1B (Neuralized E3 Ubiquitin Protein Ligase 1B) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include ligase activity. An important paralog of this gene is NEURL1.

UniProtKB/Swiss-Prot for NEURL1B Gene

  • E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL1B Gene

Genomics for NEURL1B Gene

Regulatory Elements for NEURL1B Gene

Enhancers for NEURL1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F172004 1.8 FANTOM5 Ensembl ENCODE 10.8 -633.9 -633886 5.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 NPM1 UBTD2 NEURL1B STK10 FBXW11 GC05P172013
GH05F172657 1.2 Ensembl ENCODE 12.7 +20.6 20645 8.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SP5 NEURL1B SH3PXD2B LOC100268168 ENSG00000254295 RPL26L1 GC05P172658 MIR5003
GH05F172682 1.2 Ensembl ENCODE 11.2 +42.7 42719 2.1 HDGF KLF17 BMI1 YBX1 ZNF335 ZNF121 GLIS2 SCRT2 ZNF143 ZNF207 NEURL1B DUSP1 ENSG00000253959 PIR48921 GC05P172690 PIR33579
GH05F172958 1.1 ENCODE 10.8 +318.4 318366 3.1 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 BOD1 KLF3P1 ENSG00000253628 ENSG00000253172 EFCAB9 CREBRF SH3PXD2B NEURL1B BNIP1 LOC100268168
GH05F173614 1.1 ENCODE 10.8 +974.9 974896 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 NEURL1B LOC285593 BOD1 LOC105377735
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEURL1B on UCSC Golden Path with GeneCards custom track

Promoters for NEURL1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001876593 953 2801 INSM2 ZNF76 SIN3A ZNF2 RAD21 GLIS2 FOS EGR2 SP3 REST

Genomic Location for NEURL1B Gene

172,641,247 bp from pter
172,691,540 bp from pter
50,294 bases
Plus strand

Genomic View for NEURL1B Gene

Genes around NEURL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1B Gene

Proteins for NEURL1B Gene

  • Protein details for NEURL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1B
    Protein Accession:
    Secondary Accessions:
    • C9DQJ5
    • C9DQJ6
    • C9DQJ7

    Protein attributes for NEURL1B Gene

    555 amino acids
    Molecular mass:
    59270 Da
    Quaternary structure:
    • Interacts with JAG1, DLL1 and DLL4.

    Alternative splice isoforms for NEURL1B Gene


neXtProt entry for NEURL1B Gene

Post-translational modifications for NEURL1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEURL1B Gene

No data available for DME Specific Peptides for NEURL1B Gene

Domains & Families for NEURL1B Gene

Protein Domains for NEURL1B Gene

Suggested Antigen Peptide Sequences for NEURL1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 NHR (neuralized homology repeat) domains.
  • Contains 1 RING-type zinc finger.
  • Contains 2 NHR (neuralized homology repeat) domains.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with NEURL1B: view

No data available for Gene Families for NEURL1B Gene

Function for NEURL1B Gene

Molecular function for NEURL1B Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.

Enzyme Numbers (IUBMB) for NEURL1B Gene

Gene Ontology (GO) - Molecular Function for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19723503
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NEURL1B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL1B Gene

Localization for NEURL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL1B gene
Compartment Confidence
endosome 4
nucleus 3
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

Pathways & Interactions for NEURL1B Gene

genes like me logo Genes that share pathways with NEURL1B: view

UniProtKB/Swiss-Prot A8MQ27-NEU1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0070086 ubiquitin-dependent endocytosis ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

No data available for SIGNOR curated interactions for NEURL1B Gene

Transcripts for NEURL1B Gene

mRNA/cDNA for NEURL1B Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEURL1B Gene

Neuralized homolog 1B (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1B Gene

No ASD Table

Relevant External Links for NEURL1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEURL1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEURL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NEURL1B Gene:


SOURCE GeneReport for Unigene cluster for NEURL1B Gene:


mRNA Expression by UniProt/SwissProt for NEURL1B Gene:

Tissue specificity: Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.
genes like me logo Genes that share expression patterns with NEURL1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NEURL1B Gene

Orthologs for NEURL1B Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEURL1B 34 35
  • 99.7 (n)
(Canis familiaris)
Mammalia NEURL1B 34 35
  • 93.7 (n)
(Bos Taurus)
Mammalia NEURL1B 34 35
  • 92.31 (n)
(Mus musculus)
Mammalia Neurl1b 34 16 35
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Neurl1b 34
  • 85.84 (n)
(Monodelphis domestica)
Mammalia NEURL1B 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia NEURL1B 35
  • 57 (a)
(Gallus gallus)
Aves NEURL1B 34 35
  • 70.36 (n)
(Anolis carolinensis)
Reptilia NEURL1B 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl1b 34
  • 62.23 (n)
(Danio rerio)
Actinopterygii neurl1b 35
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001999 34
  • 54 (n)
fruit fly
(Drosophila melanogaster)
Insecta neur 34 35
  • 49.02 (n)
(Caenorhabditis elegans)
Secernentea F10D7.5 34 35
  • 44.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
-- 35
  • 22 (a)
Species where no ortholog for NEURL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEURL1B Gene

Gene Tree for NEURL1B (if available)
Gene Tree for NEURL1B (if available)

Paralogs for NEURL1B Gene

Paralogs for NEURL1B Gene

(3) SIMAP similar genes for NEURL1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL1B: view

Variants for NEURL1B Gene

Sequence variations from dbSNP and Humsavar for NEURL1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035202 -- 172,665,617(+) ACCCT(C/T)GCCCT intron-variant
rs10035464 -- 172,663,294(+) GAGGC(A/G)GGTGG intron-variant
rs10039225 -- 172,657,047(+) GTCAG(C/T)CCCTC intron-variant
rs10045821 -- 172,655,150(+) aaagt(C/G)ggggg intron-variant
rs10051266 -- 172,681,581(+) AGAGA(G/T)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL1B Gene

Variant ID Type Subtype PubMed ID
nsv818392 CNV gain 17921354
nsv600289 CNV loss 21841781
nsv600287 CNV loss 21841781
nsv523045 CNV gain 19592680
nsv522263 CNV loss 19592680
nsv471055 CNV gain 18288195
nsv462526 CNV loss 19166990
nsv441974 CNV gain 18776908
nsv1119049 CNV deletion 24896259
nsv1032497 CNV gain 25217958
esv3607597 CNV loss 21293372
esv3607596 CNV gain 21293372
esv34432 CNV gain 17911159
esv2763518 CNV gain 21179565
esv2759393 CNV gain 17122850
dgv729n27 CNV gain 19166990
dgv5831n100 CNV gain 25217958
dgv208e55 CNV gain 17911159
dgv10173n54 CNV gain 21841781
dgv10172n54 CNV loss 21841781

Variation tolerance for NEURL1B Gene

Gene Damage Index Score: 3.16; 51.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL1B Gene

Disorders for NEURL1B Gene

Relevant External Links for NEURL1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEURL1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL1B Gene

Publications for NEURL1B Gene

  1. Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands. (PMID: 19723503) Rullinkov G. … Timmusk T. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. (PMID: 17003037) Song R. … Kong Y.Y. (J. Biol. Chem. 2006) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  4. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. (PMID: 25133637) Scannell Bryan M. … Ahsan H. (PLoS ONE 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for NEURL1B Gene

Sources for NEURL1B Gene

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