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Aliases for NEURL1B Gene

Aliases for NEURL1B Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1B 2 3 5
  • RING-Type E3 Ubiquitin Transferase NEURL1B 3 4
  • Neuralized-Like Protein 1B 3 4
  • Neuralized-Like Protein 3 3 4
  • Neuralized-2 3 4
  • NEURL3 3 4
  • Neur2 3 4
  • E3 Ubiquitin-Protein Ligase NEURL1B 3
  • Neuralized Homolog 1B (Drosophila) 2
  • E3 Ubiquitin-Protein Ligase NEURL3 3
  • Neuralized 2 Alternative Protein 3
  • Neuralized Homolog 1B 3
  • EC 2.3.2.27 4
  • HNeur2 3

External Ids for NEURL1B Gene

Previous GeneCards Identifiers for NEURL1B Gene

  • GC05P172002
  • GC05P167163
  • GC05P172068

Summaries for NEURL1B Gene

GeneCards Summary for NEURL1B Gene

NEURL1B (Neuralized E3 Ubiquitin Protein Ligase 1B) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and HIV Life Cycle. GO annotations related to this gene include ligase activity. An important paralog of this gene is NEURL1.

UniProtKB/Swiss-Prot for NEURL1B Gene

  • E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL1B Gene

Genomics for NEURL1B Gene

Regulatory Elements for NEURL1B Gene

Enhancers for NEURL1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G172657 1.5 Ensembl ENCODE dbSUPER 12.7 +20.6 20645 8.6 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B YY1 GLIS2 NEURL1B SH3PXD2B LOC100268168 ENSG00000254295 RPL26L1 GC05P172658 MIR5003
GH05G172682 1.2 Ensembl ENCODE 11.2 +42.7 42719 2.1 HDGF YBX1 ZNF121 GLIS2 ZNF143 ZNF207 ZNF263 SP3 JUNB TBX21 NEURL1B DUSP1 LINC01863 PIR48921 GC05P172690 PIR33579
GH05G172678 1.2 ENCODE dbSUPER 11.1 +38.2 38241 1.6 HDGF PKNOX1 ARID4B ZNF2 ZNF121 GLIS2 KLF7 ZNF263 SP3 REST NEURL1B PIR48921 GC05M172673
GH05G172564 0.9 ENCODE 11.4 -76.2 -76216 1.7 FOXA2 ATF1 MLX ARID4B DMAP1 RAD21 RARA GATA4 ZNF366 SCRT2 NEURL1B LINC01944 GC05M172579
GH05G172503 0.9 Ensembl ENCODE 11 -136.5 -136515 2.0 SOX13 ZNF680 KLF1 FOXA2 ZMYM3 NR3C1 NR2F2 ZFHX2 KDM1A IRF1 NEURL1B LOC105377727 LINC01944
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEURL1B on UCSC Golden Path with GeneCards custom track

Promoters for NEURL1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190795 553 1601 INSM2 SIN3A ZNF76 ZNF2 RAD21 GLIS2 FOS EGR2 SP3 REST

Genomic Location for NEURL1B Gene

Chromosome:
5
Start:
172,641,247 bp from pter
End:
172,691,540 bp from pter
Size:
50,294 bases
Orientation:
Plus strand

Genomic View for NEURL1B Gene

Genes around NEURL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1B Gene

Proteins for NEURL1B Gene

  • Protein details for NEURL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MQ27-NEU1B_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1B
    Protein Accession:
    A8MQ27
    Secondary Accessions:
    • C9DQJ5
    • C9DQJ6
    • C9DQJ7

    Protein attributes for NEURL1B Gene

    Size:
    555 amino acids
    Molecular mass:
    59270 Da
    Quaternary structure:
    • Interacts with JAG1, DLL1 and DLL4.

    Alternative splice isoforms for NEURL1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL1B Gene

Post-translational modifications for NEURL1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEURL1B Gene

No data available for DME Specific Peptides for NEURL1B Gene

Domains & Families for NEURL1B Gene

Protein Domains for NEURL1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEURL1B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NEURL1B Gene

Function for NEURL1B Gene

Molecular function for NEURL1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.

Enzyme Numbers (IUBMB) for NEURL1B Gene

Gene Ontology (GO) - Molecular Function for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19723503
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016874 ligase activity ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NEURL1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEURL1B Gene

Localization for NEURL1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL1B gene
Compartment Confidence
endosome 4
nucleus 3
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

Pathways & Interactions for NEURL1B Gene

genes like me logo Genes that share pathways with NEURL1B: view

UniProtKB/Swiss-Prot A8MQ27-NEU1B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for NEURL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0070086 ubiquitin-dependent endocytosis ISS --
genes like me logo Genes that share ontologies with NEURL1B: view

No data available for SIGNOR curated interactions for NEURL1B Gene

Drugs & Compounds for NEURL1B Gene

No Compound Related Data Available

Transcripts for NEURL1B Gene

mRNA/cDNA for NEURL1B Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEURL1B Gene

Neuralized homolog 1B (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1B Gene

No ASD Table

Relevant External Links for NEURL1B Gene

GeneLoc Exon Structure for
NEURL1B
ECgene alternative splicing isoforms for
NEURL1B

Expression for NEURL1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEURL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NEURL1B Gene:

NEURL1B

SOURCE GeneReport for Unigene cluster for NEURL1B Gene:

Hs.91521

mRNA Expression by UniProt/SwissProt for NEURL1B Gene:

A8MQ27-NEU1B_HUMAN
Tissue specificity: Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe.

Evidence on tissue expression from TISSUES for NEURL1B Gene

  • Liver(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NEURL1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL1B Gene

Orthologs for NEURL1B Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEURL1B 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia NEURL1B 34 35
  • 93.7 (n)
cow
(Bos Taurus)
Mammalia NEURL1B 34 35
  • 92.31 (n)
mouse
(Mus musculus)
Mammalia Neurl1b 34 16 35
  • 86.81 (n)
rat
(Rattus norvegicus)
Mammalia Neurl1b 34
  • 85.84 (n)
oppossum
(Monodelphis domestica)
Mammalia NEURL1B 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEURL1B 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEURL1B 34 35
  • 70.36 (n)
lizard
(Anolis carolinensis)
Reptilia NEURL1B 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl1b 34
  • 62.23 (n)
zebrafish
(Danio rerio)
Actinopterygii neurl1b 35
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001999 34
  • 54 (n)
fruit fly
(Drosophila melanogaster)
Insecta neur 34 35
  • 49.02 (n)
worm
(Caenorhabditis elegans)
Secernentea F10D7.5 34 35
  • 44.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for NEURL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEURL1B Gene

ENSEMBL:
Gene Tree for NEURL1B (if available)
TreeFam:
Gene Tree for NEURL1B (if available)

Paralogs for NEURL1B Gene

Paralogs for NEURL1B Gene

(3) SIMAP similar genes for NEURL1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL1B: view

Variants for NEURL1B Gene

Sequence variations from dbSNP and Humsavar for NEURL1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000133670 -- 172,662,165(+) GTCTG(A/T)TGAGT intron-variant, nc-transcript-variant
rs1000147425 -- 172,648,185(+) CGTAA(A/C)CTCTC intron-variant
rs1000157376 -- 172,648,548(+) GGTAA(C/T)TTTCC intron-variant
rs1000245332 -- 172,677,937(+) TTAAG(C/T)TGTGC intron-variant
rs1000364054 -- 172,654,715(+) CCATC(C/T)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL1B Gene

Variant ID Type Subtype PubMed ID
dgv10172n54 CNV loss 21841781
dgv10173n54 CNV gain 21841781
dgv208e55 CNV gain 17911159
dgv5831n100 CNV gain 25217958
dgv729n27 CNV gain 19166990
esv2759393 CNV gain 17122850
esv2763518 CNV gain 21179565
esv34432 CNV gain 17911159
esv3607596 CNV gain 21293372
esv3607597 CNV loss 21293372
nsv1032497 CNV gain 25217958
nsv1119049 CNV deletion 24896259
nsv441974 CNV gain 18776908
nsv462526 CNV loss 19166990
nsv471055 CNV gain 18288195
nsv522263 CNV loss 19592680
nsv523045 CNV gain 19592680
nsv600287 CNV loss 21841781
nsv600289 CNV loss 21841781
nsv818392 CNV gain 17921354

Variation tolerance for NEURL1B Gene

Gene Damage Index Score: 3.16; 51.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL1B Gene

Disorders for NEURL1B Gene

Relevant External Links for NEURL1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEURL1B

No disorders were found for NEURL1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEURL1B Gene

Publications for NEURL1B Gene

  1. Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands. (PMID: 19723503) Rullinkov G. … Timmusk T. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. (PMID: 17003037) Song R. … Kong Y.Y. (J. Biol. Chem. 2006) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  4. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. (PMID: 25133637) Scannell Bryan M. … Ahsan H. (PLoS ONE 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for NEURL1B Gene

Sources for NEURL1B Gene

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