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Aliases for NEURL1 Gene

Aliases for NEURL1 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1 2 3 5
  • Neuralized-Like Protein 1A 3 4
  • RING Finger Protein 67 3 4
  • H-Neuralized 1 3 4
  • NEURL 3 4
  • RNF67 3 4
  • Neuralized Homolog (Drosophila) 2
  • Neuralized (Drosophila)-Like 2
  • Neuralized-Like (Drosophila) 2
  • Neuralized Homolog 3
  • EC 6.3.2.- 4
  • BA416N2.1 3
  • NEURL1A 4
  • NEUR1 3
  • Neu-1 3
  • H-Neu 4
  • NEU 3

External Ids for NEURL1 Gene

Previous HGNC Symbols for NEURL1 Gene

  • NEURL

Previous GeneCards Identifiers for NEURL1 Gene

  • GC10P105253

Summaries for NEURL1 Gene

GeneCards Summary for NEURL1 Gene

NEURL1 (Neuralized E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with NEURL1 include medulloblastoma. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Signaling by NOTCH1. GO annotations related to this gene include ligase activity and translation factor activity, non-nucleic acid binding. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot for NEURL1 Gene

  • Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene Wiki entry for NEURL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL1 Gene

Genomics for NEURL1 Gene

Regulatory Elements for NEURL1 Gene

Enhancers for NEURL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEURL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEURL1 Gene

Chromosome:
10
Start:
103,493,890 bp from pter
End:
103,592,552 bp from pter
Size:
98,663 bases
Orientation:
Plus strand

Genomic View for NEURL1 Gene

Genes around NEURL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1 Gene

Proteins for NEURL1 Gene

  • Protein details for NEURL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76050-NEUL1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1
    Protein Accession:
    O76050
    Secondary Accessions:
    • Q5TDR2
    • Q5TDR3
    • Q8TAN0
    • Q9H463

    Protein attributes for NEURL1 Gene

    Size:
    574 amino acids
    Molecular mass:
    61860 Da
    Quaternary structure:
    • Interacts with CPEB3 (via N-terminal domain); the interaction increases CPEB3 ubiquitination. Interacts with DLL1.
    SequenceCaution:
    • Sequence=CAI13958.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NEURL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL1 Gene

Proteomics data for NEURL1 Gene at MOPED

Post-translational modifications for NEURL1 Gene

Other Protein References for NEURL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEURL1 Gene

Domains & Families for NEURL1 Gene

Gene Families for NEURL1 Gene

Protein Domains for NEURL1 Gene

Suggested Antigen Peptide Sequences for NEURL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76050

UniProtKB/Swiss-Prot:

NEUL1_HUMAN :
  • Contains 2 NHR (neuralized homology repeat) domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 2 NHR (neuralized homology repeat) domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with NEURL1: view

Function for NEURL1 Gene

Molecular function for NEURL1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
UniProtKB/Swiss-Prot Induction:
Down-regulated in medulloblastoma (MB).

Enzyme Numbers (IUBMB) for NEURL1 Gene

Gene Ontology (GO) - Molecular Function for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0045183 translation factor activity, non-nucleic acid binding IEA,ISS --
genes like me logo Genes that share ontologies with NEURL1: view
genes like me logo Genes that share phenotypes with NEURL1: view

Animal Models for NEURL1 Gene

MGI Knock Outs for NEURL1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEURL1 Gene

Localization for NEURL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1 Gene

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IEA --
GO:0097440 apical dendrite IEA,ISS --
genes like me logo Genes that share ontologies with NEURL1: view

No data available for Subcellular locations from COMPARTMENTS for NEURL1 Gene

Pathways & Interactions for NEURL1 Gene

genes like me logo Genes that share pathways with NEURL1: view

UniProtKB/Swiss-Prot O76050-NEUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007595 lactation IEA --
genes like me logo Genes that share ontologies with NEURL1: view

No data available for SIGNOR curated interactions for NEURL1 Gene

Drugs & Compounds for NEURL1 Gene

No Compound Related Data Available

Transcripts for NEURL1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for NEURL1 Gene

GeneLoc Exon Structure for
NEURL1
ECgene alternative splicing isoforms for
NEURL1

Expression for NEURL1 Gene

mRNA expression in normal human tissues for NEURL1 Gene

mRNA differential expression in normal tissues according to GTEx for NEURL1 Gene

This gene is overexpressed in Brain - Cortex (x4.7), Muscle - Skeletal (x4.4), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for NEURL1 Gene

This gene is overexpressed in Tlymphocyte (48.2) and Esophagus (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEURL1 Gene



mRNA Expression by UniProt/SwissProt for NEURL1 Gene

O76050-NEUL1_HUMAN
Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.
genes like me logo Genes that share expression patterns with NEURL1: view

Protein tissue co-expression partners for NEURL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NEURL1 Gene

Orthologs for NEURL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEURL 35
  • 93.03 (n)
  • 95.64 (a)
NEURL1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEURL 35
  • 93.08 (n)
  • 95.08 (a)
NEURL1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neurl1a 35
  • 91.06 (n)
  • 94.25 (a)
Neurl1a 16
Neurl1a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEURL 35
  • 98.94 (n)
  • 98.88 (a)
NEURL1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neurl1 35
  • 90.05 (n)
  • 91.4 (a)
oppossum
(Monodelphis domestica)
Mammalia NEURL1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEURL1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEURL 35
  • 73.39 (n)
  • 77.61 (a)
NEURL 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEURL1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl1 35
  • 67.03 (n)
  • 74.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia neurl-A 35
zebrafish
(Danio rerio)
Actinopterygii neurl1aa 35
  • 65.99 (n)
  • 71.09 (a)
neurl1aa 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta neur 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10D7.5 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for NEURL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEURL1 Gene

ENSEMBL:
Gene Tree for NEURL1 (if available)
TreeFam:
Gene Tree for NEURL1 (if available)

Paralogs for NEURL1 Gene

Paralogs for NEURL1 Gene

(1) SIMAP similar genes for NEURL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL1: view

Variants for NEURL1 Gene

Sequence variations from dbSNP and Humsavar for NEURL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1536224 -- 103,577,199(+) AGAGG(C/G)TTTTC intron-variant
rs1853842 -- 103,588,736(-) CATCT(C/T)CTCAC intron-variant
rs1884930 -- 103,540,380(+) tacct(A/C)ccgag intron-variant
rs1884931 -- 103,540,586(+) cgccc(A/G)gccTT intron-variant
rs3014201 -- 103,524,831(-) aaaca(A/G)catgg intron-variant

Variation tolerance for NEURL1 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL1 Gene

HapMap Linkage Disequilibrium report
NEURL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEURL1 Gene

Disorders for NEURL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEURL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEURL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEURL1
genes like me logo Genes that share disorders with NEURL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEURL1 Gene

Publications for NEURL1 Gene

  1. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PMID: 20847082) Teider N. … Pomeroy S.L. (Neuro-oncology 2010) 2 3 4 67
  2. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PMID: 9519875) Nakamura H. … Saya H. (Oncogene 1998) 2 3
  3. Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1. (PMID: 26276215) Lee H.J. … Park H.S. (Biochim. Biophys. Acta 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. (PMID: 25124494) Sinner M.F. … Ellinor P.T. (Circulation 2014) 3

Products for NEURL1 Gene

Sources for NEURL1 Gene

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