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Aliases for NEURL1 Gene

Aliases for NEURL1 Gene

  • Neuralized E3 Ubiquitin Protein Ligase 1 2 3 5
  • RING-Type E3 Ubiquitin Transferase NEURL1 3 4
  • Neuralized-Like Protein 1A 3 4
  • RING Finger Protein 67 3 4
  • H-Neuralized 1 3 4
  • NEURL 3 4
  • RNF67 3 4
  • E3 Ubiquitin-Protein Ligase NEURL1 3
  • Neuralized Homolog (Drosophila) 2
  • Neuralized (Drosophila)-Like 2
  • Neuralized-Like (Drosophila) 2
  • Neuralized Homolog 3
  • EC 2.3.2.27 4
  • BA416N2.1 3
  • NEURL1A 4
  • NEUR1 3
  • Neu-1 3
  • H-Neu 4
  • NEU 3

External Ids for NEURL1 Gene

Previous HGNC Symbols for NEURL1 Gene

  • NEURL

Previous GeneCards Identifiers for NEURL1 Gene

  • GC10P105253

Summaries for NEURL1 Gene

GeneCards Summary for NEURL1 Gene

NEURL1 (Neuralized E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with NEURL1 include Medulloblastoma. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include ligase activity and translation factor activity, non-nucleic acid binding. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot for NEURL1 Gene

  • Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene Wiki entry for NEURL1 Gene

Additional gene information for NEURL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEURL1 Gene

Genomics for NEURL1 Gene

Regulatory Elements for NEURL1 Gene

Enhancers for NEURL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H103578 1.2 ENCODE dbSUPER 16.2 +86.2 86152 3 ELF3 MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA TCF12 SLC30A9 SCRT2 NEURL1 NEURL1-AS1 CALHM2 STN1 GC10P103582 ENSG00000226431
GH10H103470 1.5 FANTOM5 Ensembl ENCODE 11.7 -22.0 -21957 3 HDAC1 PKNOX1 KLF17 BATF EGR1 FOS ATF7 ETV6 RUNX3 CREM NEURL1 AS3MT NEURL1-AS1 CALHM2 RNU11-3P NT5C2 CALHM3 CALHM1
GH10H103614 1.5 Ensembl ENCODE dbSUPER 10 +123.8 123812 7 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ELK1 NCOA1 ZNF592 MEF2D NEURL1-AS1 NEURL1 CALHM2 SH3PXD2A GC10M103620 PIR62337 PIR45243
GH10H103691 1.4 FANTOM5 ENCODE dbSUPER 10.2 +197.7 197728 0 HDGF PKNOX1 ZNF133 SIN3A ZNF2 GLIS2 EGR1 ZNF416 ZNF207 ATF7 ENSG00000260461 PCGF6 LOC101927523 SORCS3-AS1 LOC105378464 SFR1 SLK SH3PXD2A NEURL1 NEURL1-AS1
GH10H103526 1.2 Ensembl ENCODE 11.5 +33.9 33914 3 ZNF155 ZNF366 FOS ATF7 SP3 ZNF362 CAVIN1 CEBPB ZEB2 ZNF662 PCGF6 PDCD11 ENSG00000260461 NEURL1 ENSG00000234699 CALHM2 SH3PXD2A CALHM1 NEURL1-AS1 ENSG00000226431
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEURL1 on UCSC Golden Path with GeneCards custom track

Promoters for NEURL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032893 110 801 MXI1 KLF17 ZIC2 ZNF2 BCL11B ZEB1 HIC1 GLIS2 POLR2A PATZ1

Genomic Location for NEURL1 Gene

Chromosome:
10
Start:
103,493,890 bp from pter
End:
103,592,552 bp from pter
Size:
98,663 bases
Orientation:
Plus strand

Genomic View for NEURL1 Gene

Genes around NEURL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEURL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEURL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEURL1 Gene

Proteins for NEURL1 Gene

  • Protein details for NEURL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76050-NEUL1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEURL1
    Protein Accession:
    O76050
    Secondary Accessions:
    • Q5TDR2
    • Q5TDR3
    • Q8TAN0
    • Q9H463

    Protein attributes for NEURL1 Gene

    Size:
    574 amino acids
    Molecular mass:
    61860 Da
    Quaternary structure:
    • Interacts with CPEB3 (via N-terminal domain); the interaction increases CPEB3 ubiquitination. Interacts with DLL1.
    SequenceCaution:
    • Sequence=CAI13958.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13959.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NEURL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEURL1 Gene

Post-translational modifications for NEURL1 Gene

No data available for DME Specific Peptides for NEURL1 Gene

Domains & Families for NEURL1 Gene

Gene Families for NEURL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NEURL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NEURL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEURL1: view

No data available for UniProtKB/Swiss-Prot for NEURL1 Gene

Function for NEURL1 Gene

Molecular function for NEURL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
UniProtKB/Swiss-Prot Induction:
Down-regulated in medulloblastoma (MB).

Enzyme Numbers (IUBMB) for NEURL1 Gene

Phenotypes From GWAS Catalog for NEURL1 Gene

Gene Ontology (GO) - Molecular Function for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0045183 translation factor activity, non-nucleic acid binding IEA,ISS --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with NEURL1: view
genes like me logo Genes that share phenotypes with NEURL1: view

Animal Models for NEURL1 Gene

MGI Knock Outs for NEURL1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEURL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEURL1 Gene

Localization for NEURL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEURL1 Gene

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEURL1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,IDA 20847082
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with NEURL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NEURL1 Gene

Pathways & Interactions for NEURL1 Gene

genes like me logo Genes that share pathways with NEURL1: view

UniProtKB/Swiss-Prot O76050-NEUL1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for NEURL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006513 protein monoubiquitination ISS,IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0007288 sperm axoneme assembly IEA --
GO:0007399 nervous system development TAS 9519875
genes like me logo Genes that share ontologies with NEURL1: view

No data available for SIGNOR curated interactions for NEURL1 Gene

Drugs & Compounds for NEURL1 Gene

No Compound Related Data Available

Transcripts for NEURL1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NEURL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for NEURL1 Gene

GeneLoc Exon Structure for
NEURL1
ECgene alternative splicing isoforms for
NEURL1

Expression for NEURL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEURL1 Gene

mRNA differential expression in normal tissues according to GTEx for NEURL1 Gene

This gene is overexpressed in Brain - Cortex (x4.7), Muscle - Skeletal (x4.4), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for NEURL1 Gene

This gene is overexpressed in Tlymphocyte (48.2) and Esophagus (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEURL1 Gene



Protein tissue co-expression partners for NEURL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEURL1 Gene:

NEURL1

mRNA Expression by UniProt/SwissProt for NEURL1 Gene:

O76050-NEUL1_HUMAN
Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Evidence on tissue expression from TISSUES for NEURL1 Gene

  • Nervous system(4.9)
  • Eye(3.8)
  • Pancreas(3.7)
  • Skin(3.6)
  • Lung(3.4)
  • Intestine(2.7)
  • Liver(2.6)
genes like me logo Genes that share expression patterns with NEURL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEURL1 Gene

Orthologs for NEURL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEURL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEURL 33
  • 98.94 (n)
NEURL1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEURL1 34
  • 96 (a)
OneToOne
NEURL 33
  • 93.03 (n)
dog
(Canis familiaris)
Mammalia NEURL1 34
  • 95 (a)
OneToOne
NEURL 33
  • 93.08 (n)
mouse
(Mus musculus)
Mammalia Neurl1a 33 16 34
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Neurl1 33
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia NEURL1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEURL1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEURL 33 34
  • 73.39 (n)
lizard
(Anolis carolinensis)
Reptilia NEURL1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neurl1 33
  • 67.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia neurl-A 33
zebrafish
(Danio rerio)
Actinopterygii neurl1aa 33 34
  • 65.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta neur 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10D7.5 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
Species where no ortholog for NEURL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEURL1 Gene

ENSEMBL:
Gene Tree for NEURL1 (if available)
TreeFam:
Gene Tree for NEURL1 (if available)

Paralogs for NEURL1 Gene

Paralogs for NEURL1 Gene

(1) SIMAP similar genes for NEURL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEURL1: view

Variants for NEURL1 Gene

Sequence variations from dbSNP and Humsavar for NEURL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000009401 -- 103,551,342(+) CTGTC(A/G)CCCAG intron-variant
rs1000091317 -- 103,537,599(+) ATGTT(G/T)CCCAG intron-variant
rs1000094407 -- 103,531,777(+) AGTCT(C/T)CCAAA intron-variant
rs1000097201 -- 103,557,728(+) CCCTA(C/G)CTGCC intron-variant, upstream-variant-2KB
rs1000157875 -- 103,513,261(+) TTTAG(C/T)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEURL1 Gene

Variant ID Type Subtype PubMed ID
dgv966n100 CNV gain 25217958
esv27747 CNV gain 19812545
esv3577694 CNV gain 25503493
esv3624417 CNV loss 21293372
esv3624418 CNV gain 21293372
nsv524966 CNV loss 19592680

Variation tolerance for NEURL1 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEURL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEURL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEURL1 Gene

Disorders for NEURL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEURL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NEURL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEURL1
genes like me logo Genes that share disorders with NEURL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEURL1 Gene

Publications for NEURL1 Gene

  1. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PMID: 20847082) Teider N … Pomeroy SL (Neuro-oncology 2010) 2 3 4 60
  2. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PMID: 9519875) Nakamura H … Saya H (Oncogene 1998) 2 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. (PMID: 11585928) Vollrath B … Fitzgerald K (Molecular and cellular biology 2001) 3 4 60

Products for NEURL1 Gene

Sources for NEURL1 Gene

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