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NEURL1 Gene

protein-coding   GIFtS: 41
GCID: GC10P105253

Neuralized E3 Ubiquitin Protein Ligase 1

(Previous names: neuralized (Drosophila)-like, neuralized-like (Drosophila),...)
(Previous symbol: NEURL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuralized E3 Ubiquitin Protein Ligase 11 2     bA416N2.12
NEURL1 2 3 5     E3 Ubiquitin-Protein Ligase NEURL12
Neuralized-Like Protein 1A2 3     neu2
RNF672 3     neu-12
H-Neuralized 12 3     Neuralized Homolog2
RING Finger Protein 672 3     EC 6.3.2.-3
Neuralized (Drosophila)-Like1     NEURL1A3
Neuralized Homolog (Drosophila)1     h-neu3
Neuralized-Like (Drosophila)1     

External Ids:    HGNC: 77611   Entrez Gene: 91482   Ensembl: ENSG000001079547   OMIM: 6038045   UniProtKB: O760503   

Export aliases for NEURL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEURL1 Gene:
NEURL1 (neuralized E3 ubiquitin protein ligase 1) is a protein-coding gene. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot: NEUL1_HUMAN, O76050
Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the
formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic
polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces
CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3
ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway.
Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting
the Notch signaling pathway

Gene Wiki entry for NEURL1 (NEURL) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NEURL1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEURL1 promoter sequence
   Search Chromatin IP Primers for NEURL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEURL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

NEURL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105253:  view genomic region     (about GC identifiers)

Start:
105,253,735 bp from pter      End:
105,352,309 bp from pter
Size:
98,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NEUL1_HUMAN, O76050 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NEURL1  
Size: 574 amino acids; 61860 Da
Subunit: Interacts with CPEB3 (via N-terminus domain); the interaction increases CPEB3 ubiquitination (By
similarity)
Sequence caution: Sequence=CAI13958.1; Type=Erroneous gene model prediction; Sequence=CAI13959.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q5TDR2 Q5TDR3 Q8TAN0 Q9H463
Alternative splicing: 2 isoforms:  O76050-1   O76050-2   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for NEURL1: NX_O76050

Explore proteomics data for NEURL1 at MOPED

Post-translational modifications: 

  • Myristoylation is a determinant of membrane targeting (By similarity)1
  • Modification sites at neXtProt

  • See NEURL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004201.3  
    ENSEMBL proteins: 
     ENSP00000358795   ENSP00000416709   ENSP00000387714   ENSP00000358792  
    Reactome Protein details: O76050

    NEURL1 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for NEURL1 (2 products) 

     
    antibodies-online peptides for NEURL1

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    antibodies-online antibodies for NEURL1 (56 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR006573 Neu_Z
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O76050

    ProtoNet protein and cluster: O76050

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: NEUL1_HUMAN, O76050
    Similarity: Contains 2 NHR (neuralized homology repeat) domains
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with NEURL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUL1_HUMAN, O76050
    Function: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the
    formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic
    polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces
    CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3
    ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway.
    Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting
    the Notch signaling pathway
    Induction: Down-regulated in medulloblastoma (MB)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0045183translation factor activity, non-nucleic acid binding ISS--
         
    Find genes that share ontologies with NEURL1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neurl1a):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  integument 
     nervous system  normal  reproductive system  tumorigenesis 

    Find genes that share phenotypes with NEURL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Neurl1atm1Ynj for NEURL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEURL1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEUL1_HUMAN, O76050: Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein (By similarity).
    Perikaryon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse, postsynaptic cell
    membrane, postsynaptic density (By similarity). Note=Localized in the cell bodies of the pyramidal neurons and
    distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at
    apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density ISS--
    GO:0030054cell junction IEA--
    GO:0043197dendritic spine ISS--

    Find genes that share ontologies with NEURL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEURL1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    2Signaling by NOTCH2
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.67
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    Signaling by NOTCH20.67
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4Notch signaling pathway (Pathway Interaction Database)
    Notch signaling pathway
    5Disease
    Disease


    Find genes that share SuperPaths with NEURL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NEURL1
        Notch signaling pathway

    5 Reactome Pathways for NEURL1
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH2 Activation and Transmission of Signal to the Nucleus
    Constitutive Signaling by NOTCH1 HD Domain Mutants
    Activated NOTCH1 Transmits Signal to the Nucleus
    Constitutive Signaling by NOTCH1 PEST Domain Mutants


    UniProtKB/Swiss-Prot: NEUL1_HUMAN, O76050
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEURL1
    Interactions:

        Search GeneGlobe Interaction Network for NEURL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEURL1 (O760503 ENSP000003587954) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    CPEB3Q8NE353, ENSP000002659974I2D: score=1 STRING: ENSP00000265997
    ERBB2ENSP000002695714STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006513protein monoubiquitination ISS--
    GO:0007219Notch signaling pathway IEA--
    GO:0007288sperm axoneme assembly IEA--
    GO:0007399nervous system development TAS9519875
    GO:0007420brain development IEA--

    Find genes that share ontologies with NEURL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEURL1 (NEUL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEURL1 gene: 
    NM_004210.4  

    Unigene Cluster for NEURL1:

    Neuralized homolog (Drosophila)
    Hs.594708  [show with all ESTs]
    Unigene Representative Sequence: NM_004210
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369780(uc001kxh.3) ENST00000437579 ENST00000455386 ENST00000465048
    ENST00000369777(uc021pxn.1)
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    Additional mRNA sequence: 

    AF029729.1 AK299620.1 BC026336.1 BX648827.1 U87864.1 

    14 DOTS entries:

    DT.95137847  DT.315206  DT.454491  DT.95263200  DT.121244660  DT.97859116  DT.87046983  DT.97859117 
    DT.121244722  DT.100682224  DT.100820769  DT.405394  DT.92422740  DT.99940506 

    Selected AceView cDNA sequences (see all 187):

    AI216388 CR607490 BF591302 BQ778364 BM724707 BQ417444 BM678351 BM930569 
    BU071214 BQ632047 CA843851 AA338166 BM712445 BM713432 BQ186269 BQ286290 
    CB068797 BM314444 AW205080 AA338165 AA971863 BG656185 BM930417 BU951423 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NEURL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -     -                                   -                     
    SP2:              -                                                         
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for NEURL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEURL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEURL1 Expression
    About this image

    NEURL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEURL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594708

    UniProtKB/Swiss-Prot: NEUL1_HUMAN, O76050
    Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed
    in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma
    (MB) compared with normal cerebellar tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEURL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurl1a1 , 5 neuralized homolog 1A (Drosophila)1, 5 91.06(n)1
    94.25(a)1
      19 (39.39 cM)5
    180111  NM_021360.41  NP_067335.41 
     471788205 
    chicken
    (Gallus gallus)
    Aves NEURL1 neuralized homolog (Drosophila) 73.39(n)
    77.61(a)
      423875  NM_001012910.1  NP_001012928.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEURL16
    neuralized E3 ubiquitin protein ligase 1
    76(a)
    1 ↔ 1
    3(40885070-40981533)
    African clawed frog
    (Xenopus laevis)
    Amphibia neurl-A2 neuralized 73.56(n)    AF419159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurl1aa1 neuralized homolog 1Aa (Drosophila) 65.99(n)
    71.09(a)
      561943  NM_001077558.1  NP_001071026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta neur6
    neuralized
    21(a)
    1 → many
    3R(4846068-4865189)
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.56
    Protein F10D7.5, isoform e
    25(a)
    1 → many
    X(17382994-17391561) WBGene00017342


    ENSEMBL Gene Tree for NEURL1 (if available)
    TreeFam Gene Tree for NEURL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEURL1 gene
    NEURL1B2  
    1 SIMAP similar gene for NEURL1 using alignment to 1 protein entry:     NEUL1_HUMAN:
    NEURL1B

    Find genes that share paralogs with NEURL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEURL1 (see all 1837)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130221481,2
    F--105251829(+) TGTAGC/TGGTGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs124140031,2
    C,H--105251832(+) AGCGGG/TGTGTT 1 -- us2k10--------
    rs1392062991,2
    --105251847(+) CATGTC/GTGAGT 1 -- us2k10--------
    rs1431539321,2
    --105251984(+) CACACA/GTGATC 1 -- us2k10--------
    rs1431185321,2
    C--105252060(+) TGGCT-/GGGG  
      
    /GGGGG
    GTCAC
    1 -- us2k10--------
    rs1890459241,2
    --105252287(+) GGACAA/CCCTGG 1 -- us2k10--------
    rs1474831791,2
    --105252297(+) GTGAAA/CACGAC 1 -- us2k10--------
    rs1392695861,2
    --105252322(+) CCCTCA/CCAGAG 1 -- us2k10--------
    rs1495589341,2
    --105252388(+) GTTCCA/TTATAA 1 -- us2k10--------
    rs1144437981,2
    C,F--105252500(+) CTAGAT/CAATGA 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for NEURL1 (105253735 - 105352309 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NEURL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEURL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NEURL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603804    OMIM disorders: --


    Find genes that share disorders with NEURL1           About GenesLikeMe


    Export disorders for NEURL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEURL1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NEURL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PubMed id 20847082)1, 2, 3 Teider N....Pomeroy S.L. (Neuro-oncology 2010)
    2. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PubMed id 9519875)1, 2, 3 Nakamura H.... Saya H. (Oncogene 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. (PubMed id 11585928)1, 2 Vollrath B.... Fitzgerald K. (Mol. Cell. Biol. 2001)
    6. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
    7. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PubMed id 20526338)1 Johnson A.D....Becker L.C. (Nat. Genet. 2010)
    8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1. (PubMed id 18077452)1 Koutelou E....Moschonas N.K. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9148 HGNC: 7761 AceView: NEURL Ensembl:ENSG00000107954 euGenes: HUgn9148
    ECgene: NEURL1 H-InvDB: NEURL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEURL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEURL1 gene:
    Search GeneIP for patents involving NEURL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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