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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEURL Gene

protein-coding   GIFtS: 54
GCID: GC10P105244

neuralized homolog (Drosophila)

(Previous names: neuralized (Drosophila)-like, neuralized-like (Drosophila)...)
 Explore 4 diseases affiliated with
NEURL via our new
 Human Malady Compendium 
Biological research products
for NEURL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neuralized Homolog (Drosophila)1 2     Neuralized (Drosophila)-Like1
NEURL11 2 3     Neuralized-Like (Drosophila)1
RNF671 2 3     BA416N2.11
Neu-11     Neu1
H-Neu1     Neuralized-Like Protein 1A2
H-Neuralized 12 3     EC 6.3.2.-3
RING Finger Protein 672 3     NEURL1A3

External Ids:    HGNC: 77611   Entrez Gene: 91482   Ensembl: ENSG000001079547   OMIM: 6038045   UniProtKB: O760503   

Export aliases for NEURL gene to outside databases

Previous GC identifers: GC10P104147 GC10P104487 GC10P105384 GC10P104918 GC10P098884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
Function: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the
Notch pathway (By similarity)

Gene Wiki entry for NEURL


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEURL gene promoter:
         AhR   C/EBPbeta   AML1a   Bach2   YY1   AREB6   CREB   deltaCREB   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEURL promoter sequence
   Search SABiosciences Chromatin IP Primers for NEURL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

NEURL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105244:  view genomic region     (about GC identifiers)

Start:
105,253,735 bp from pter      End:
105,352,309 bp from pter
Size:
98,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050 (See protein sequence)
Recommended Name: Neuralized-like protein 1A  
Size: 574 amino acids; 61860 Da
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm, perinuclear region
Sequence caution: Sequence=CAI13958.1; Type=Erroneous gene model prediction; Sequence=CAI13959.1; Type=Erroneous gene
model prediction;
Secondary accessions: Q5TDR2 Q5TDR3 Q8TAN0 Q9H463
Alternative splicing: 2 isoforms:  O76050-1   O76050-2   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for NEURL: NX_O76050

Post-translational modifications:

  • Myristoylation is a determinant of membrane targeting (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O76050

  • NEURL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004201.3  
    ENSEMBL proteins: 
     ENSP00000358795   ENSP00000416709   ENSP00000387714   ENSP00000358792  
    Reactome Protein details: O76050
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NEURL 
    GenScript Custom Purified and Recombinant Proteins Services for NEURL
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEURL

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    NEURL for ontologies           About GeneDecksing



    NEURL Antibody Products: 
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    Novus Biologicals NEURL Antibodies
    Search for Antibodies for NEURL at Abcam  
    Uscn Antibodies for NEURL
    Search ThermoFisher Antibodies for NEURL

    Assay Products for NEURL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEURL
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEURL


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NEURL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001841 Znf_RING
     IPR006573 Neu_Z
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O76050

    ProtoNet protein and cluster: O76050

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Similarity: Contains 2 NHR (neuralized homology repeat) domains
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Function: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the
    Notch pathway (By similarity)

         Genatlas biochemistry entry for NEURL:
    Drosophila neuralized homolog within the malignant astrocytoma region on chromosome 10,expressed in brain,potentially
    involved in neurogenesis

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    OriGene 3'-UTR Clone: NEURL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL:
    hsa-miR-513b hsa-miR-135b hsa-miR-1184 hsa-miR-324-3p hsa-miR-561 hsa-miR-1207-3p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNEURL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEURL
    OriGene shRNA RFP: NEURL
    OriGene siRNA: NEURL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NEURL

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEURL (NM_004210)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEURL 

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    GenScript Custom overexpressing Cell Line Services for NEURL
    Search LifeMap BioReagents cell lines for NEURL

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--


    NEURL for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Neurl1atm1Ynj for NEURL
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neurl1a):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  integument 
     nervous system  normal  reproductive system  tumorigenesis 

    NEURL for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/10 pathways (see all 10)
    Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    Signaling by NOTCH11.00
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    Signaling by NOTCH1 in Cancer1.00
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    Signaling by NOTCH0.77
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    NOTCH2 Activation and Transmission of Signal to the Nucleus1.00
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.62
    Signaling by NOTCH21.00
    Activated NOTCH1 Transmits Signal to the Nucleus0.58
    3Disease
    Disease1.00
    4Notch signaling pathway
    Notch signaling pathway1.00
    5Signaling by GPCR
    Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NEURL 
        Notch signaling pathway

    5/16        Reactome Pathways for NEURL (see all 16)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Pathway: Protein modification; protein ubiquitination


    NEURL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEURL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for NEURL (O760503 ENSP000003587954) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    CPEB3Q8NE353I2D: score=1 
    ERBB2ENSP000002695714STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0007288sperm axoneme assembly IEA--
    GO:0007399nervous system development TAS9519875
    GO:0007420brain development IEA--
    GO:0007519skeletal muscle tissue development IEA--


    NEURL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEURL
    Search CenterWatch for drugs/clinical trials and news about NEURL / NEU1A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEURL gene: 
    NM_004210.4  

    Unigene Cluster for NEURL:

    Neuralized homolog (Drosophila)
    Hs.594708  [show with all ESTs]
    Unigene Representative Sequence: NM_004210
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369780(uc001kxh.3) ENST00000437579 ENST00000455386 ENST00000465048
    ENST00000369777(uc021pxn.1)

    miRNA
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    OriGene 3'-UTR Clone: NEURL
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL:
    hsa-miR-513b hsa-miR-135b hsa-miR-1184 hsa-miR-324-3p hsa-miR-561 hsa-miR-1207-3p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNEURL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEURL
    OriGene shRNA RFP: NEURL
    OriGene siRNA: NEURL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEURL
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEURL (NM_004210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEURL 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEURL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL

    Additional cDNA sequence: 

    AF029729.1 AK299620.1 BC026336.1 BX648827.1 U87864.1 

    14 DOTS entries:

    DT.95137847  DT.315206  DT.454491  DT.95263200  DT.121244660  DT.97859116  DT.87046983  DT.97859117 
    DT.121244722  DT.100682224  DT.100820769  DT.405394  DT.92422740  DT.99940506 

    24/187 AceView cDNA sequences (see all 187):

    BQ638204 CR607490 BM314748 AA338165 AA573184 CA775047 BM713432 BM930569 
    AA338166 BQ286290 BQ778364 BU071214 CA941491 BU951423 BQ638422 AI096380 
    BM724707 BM314444 AW205080 AW449663 BQ632047 BQ186269 CA843851 BM930417 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NEURL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -     -                                   -                     
    SP2:              -                                                         
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for NEURL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEURL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NEURL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEURL

    SOURCE GeneReport for Unigene cluster: Hs.594708

    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an
    malignant astrocytomas and several neuroectodermal tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including NEURL: 
              Notch Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEURL gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NEURL1 neuralized homolog (Drosophila) 73.39(n)
    77.61(a)
      423875  NM_001012910.1  NP_001012928.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEURL6
    --
    77(a)
    1 ↔ 1
    3(40917512-40981533)
    African clawed frog
    (Xenopus laevis)
    Amphibia neurl-A2 neuralized 73.56(n)    AF419159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurla1 neuralized homolog a (Drosophila) 65.99(n)
    71.09(a)
      561943  NM_001077558.1  NP_001071026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta neur3 determination of sensory organ precursor
    cell more
    40(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.5a3 D. melanogaster finger protein neuralized 31(a)   X(17414408-17423187)   --


    ENSEMBL Gene Tree for NEURL (if available)
    TreeFam Gene Tree for NEURL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEURL gene
    NEURL22  NEURL1B2  
    1 SIMAP similar gene for NEURL using alignment to 2 protein entries:     NEU1A_HUMAN (see all proteins):
    NEURL1B

    NEURL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1514 NCBI SNPs in NEURL are shown (see all 1514    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130221481,2
    --105251829(+) TGTAGC/TGGTGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs124140031,2
    C,H--105251832(+) AGCGGG/TGTGTT 1 -- us2k10--------
    rs1392062991,2
    --105251847(+) CATGTC/GTGAGT 1 -- us2k10--------
    rs1431539321,2
    --105251984(+) CACACA/GTGATC 1 -- us2k10--------
    rs1431185321,2
    C,--105252060(+) TGGCT-/GGGG  
            
    GTCAC
    1 -- us2k10--------
    rs1890459241,2
    --105252287(+) GGACAA/CCCTGG 1 -- us2k10--------
    rs1474831791,2
    --105252297(+) GTGAAA/CACGAC 1 -- us2k10--------
    rs1392695861,2
    --105252322(+) CCCTCA/CCAGAG 1 -- us2k10--------
    rs1495589341,2
    --105252388(+) GTTCCA/TTATAA 1 -- us2k10--------
    rs1144437981,2
    F,--105252500(+) CTAGAT/CAATGA 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for NEURL (105253735 - 105352309 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NEURL
         1 CNV: 65776

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEURL
    DNA2.0 Custom Variant and Variant Library Synthesis for NEURL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NEURL for disorders           About GeneDecksing

    OMIM gene information: 603804    OMIM disorders: --

    4 diseases for NEURL:    About MalaCards
    neuroectodermal tumors    medulloblastoma    alzheimer's disease    astrocytoma

    Human Genome Epidemiology (HuGE) Navigator: NEURL (1 document)

    Export disorders for NEURL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEURL gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NEURL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PubMed id 9519875)1, 2, 3 Nakamura H.... Saya H. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. (PubMed id 11585928)1, 2 Vollrath B.... Fitzgerald K. (2001)
    5. Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)1 Johnson A.D....Becker L.C. (2010)
    6. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PubMed id 20847082)1 Teider N....Pomeroy S.L. (2010)
    7. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Neuralized-like 1 (Neurl1) targeted to the plasma mem brane by N-myristoylation regulates the Notch ligand Jagged1. (PubMed id 18077452)1 Koutelou E....Moschonas N.K. (2008)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9148 HGNC: 7761 AceView: NEURL Ensembl:ENSG00000107954 euGenes: HUgn9148
    ECgene: NEURL H-InvDB: NEURL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEURL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEURL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEURL gene:
    Search GeneIP for patents involving NEURL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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