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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEURL Gene

protein-coding   GIFtS: 54
GCID: GC10P105244

Neuralized Homolog (Drosophila)

(Previous names: neuralized (Drosophila)-like, neuralized-like (Drosophila))
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuralized Homolog (Drosophila)1 2     bA416N2.12
NEURL12 3     neu2
RNF672 3     neu-12
H-Neuralized 12 3     Neuralized-Like Protein 1A2
RING Finger Protein 672 3     EC 6.3.2.-3
Neuralized (Drosophila)-Like1     NEURL1A3
Neuralized-Like (Drosophila)1     h-neu3

External Ids:    HGNC: 77611   Entrez Gene: 91482   Ensembl: ENSG000001079547   OMIM: 6038045   UniProtKB: O760503   

Export aliases for NEURL gene to outside databases

Previous GC identifers: GC10P104147 GC10P104487 GC10P105384 GC10P104918 GC10P098884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NEURL Gene: 
NEURL (neuralized homolog (Drosophila)) is a protein-coding gene. Diseases associated with NEURL include medulloblastoma, and astrocytoma, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is NEURL1B.

UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
Function: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby
regulating the Notch pathway (By similarity)

Gene Wiki entry for NEURL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEURL gene promoter:
         AhR   C/EBPbeta   AML1a   Bach2   YY1   AREB6   CREB   deltaCREB   TGIF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEURL promoter sequence
   Search SABiosciences Chromatin IP Primers for NEURL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEURL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.1   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

NEURL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEURL gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105244:  view genomic region     (about GC identifiers)

Start:
105,253,735 bp from pter      End:
105,352,309 bp from pter
Size:
98,575 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050 (See protein sequence)
Recommended Name: Neuralized-like protein 1A  
Size: 574 amino acids; 61860 Da
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm, perinuclear region
Sequence caution: Sequence=CAI13958.1; Type=Erroneous gene model prediction; Sequence=CAI13959.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q5TDR2 Q5TDR3 Q8TAN0 Q9H463
Alternative splicing: 2 isoforms:  O76050-1   O76050-2   (Gene prediction confirmed by EST data)

Explore the universe of human proteins at neXtProt for NEURL: NX_O76050

Explore proteomics data for NEURL at MOPED 

Post-translational modifications:

  • UniProtKB: Myristoylation is a determinant of membrane targeting (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76050

  • NEURL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEURL Protein Expression
    REFSEQ proteins: NP_004201.3  
    ENSEMBL proteins: 
     ENSP00000358795   ENSP00000416709   ENSP00000387714   ENSP00000358792  
    Reactome Protein details: O76050
    Human Recombinant Protein Products for NEURL: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NEURL
    GenScript Custom Purified and Recombinant Proteins Services for NEURL
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEURL 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    NEURL for ontologies           About GeneDecksing



    NEURL Antibody Products: 
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    GenScript Custom Superior Antibodies Services for NEURL
    Novus Biologicals NEURL Antibodies
    Search for Antibodies for NEURL at Abcam
    Cloud-Clone Corp. Antibodies for NEURL 
    Search ThermoFisher Antibodies for NEURL
    LSBio Antibodies in human, mouse, rat for NEURL 

    Assay Products for NEURL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEURL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEURL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEURL 
    Cloud-Clone Corp. CLIAs for NEURL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR006573 Neu_Z
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O76050

    ProtoNet protein and cluster: O76050

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Similarity: Contains 2 NHR (neuralized homology repeat) domains
    Similarity: Contains 1 RING-type zinc finger


    NEURL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEU1A_HUMAN, O76050
    Function: May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby
    regulating the Notch pathway (By similarity)

         Genatlas biochemistry entry for NEURL:
    Drosophila neuralized homolog within the malignant astrocytoma region on chromosome 10,expressed in
    brain,potentially involved in neurogenesis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    NEURL for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neurl1a):
     behavior/neurological  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  integument 
     nervous system  normal  reproductive system  tumorigenesis 

    NEURL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neurl1atm1Ynj for NEURL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEURL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEURL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEURL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEURL 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL:
    hsa-miR-513b hsa-miR-135b hsa-miR-1184 hsa-miR-324-3p hsa-miR-561 hsa-miR-1207-3p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNEURL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEURL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEURL
    Sirion Biotech Customized adenovirus for overexpression of NEURL

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEURL (see all 6)
    OriGene ORF clones in mouse, rat for NEURL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEURL (NM_004210)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEURL
    Sirion Biotech Customized lentivirus for stable overexpression of NEURL 
                         Customized lentivirus expression plasmids for stable overexpression of NEURL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NEURL
    Search LifeMap BioReagents cell lines for NEURL
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEURL About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    2NOTCH2 intracellular domain regulates transcription
    Signaling by NOTCH20.66
    Activated NOTCH1 Transmits Signal to the Nucleus0.59
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.66
    3Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.61
    4Signaling by GPCR
    Signal Transduction0.55
    5Notch signaling pathway
    Notch signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NEURL
        Notch signaling pathway

    5/16        Reactome Pathways for NEURL (see all 16)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Pathway: Protein modification; protein ubiquitination


    NEURL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEURL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for NEURL (O760503 ENSP000003587954) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    JAG1P785043, ENSP000002549584I2D: score=1 STRING: ENSP00000254958
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    CPEB3Q8NE353I2D: score=1 
    ERBB2ENSP000002695714STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway IEA--
    GO:0007288sperm axoneme assembly IEA--
    GO:0007399nervous system development TAS9519875
    GO:0007420brain development IEA--
    GO:0007519skeletal muscle tissue development IEA--

    NEURL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEURL (NEU1A)

    Search CenterWatch for drugs/clinical trials and news about NEURL / NEU1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEURL gene: 
    NM_004210.4  

    Unigene Cluster for NEURL:

    Neuralized homolog (Drosophila)
    Hs.594708  [show with all ESTs]
    Unigene Representative Sequence: NM_004210
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369780(uc001kxh.3) ENST00000437579 ENST00000455386 ENST00000465048
    ENST00000369777(uc021pxn.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEURL
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate NEURL:
    hsa-miR-513b hsa-miR-135b hsa-miR-1184 hsa-miR-324-3p hsa-miR-561 hsa-miR-1207-3p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidNEURL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEURL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEURL
    Clone
    Products:
         
    OriGene clones in human, mouse for NEURL (see all 6)
    OriGene ORF clones in mouse, rat for NEURL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEURL (NM_004210)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEURL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEURL
    Sirion Biotech Customized lentivirus for stable overexpression of NEURL 
                         Customized lentivirus expression plasmids for stable overexpression of NEURL 
    Primer
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    OriGene qPCR primer pairs and template standards for NEURL
    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL

    Additional mRNA sequence: 

    AF029729.1 AK299620.1 BC026336.1 BX648827.1 U87864.1 

    14 DOTS entries:

    DT.95137847  DT.315206  DT.454491  DT.95263200  DT.121244660  DT.97859116  DT.87046983  DT.97859117 
    DT.121244722  DT.100682224  DT.100820769  DT.405394  DT.92422740  DT.99940506 

    24/187 AceView cDNA sequences (see all 187):

    BE468193 AI216388 AI739022 BQ638204 BQ287987 AI142671 AI096380 BF591302 
    BU952430 CB068797 CA774789 BI712632 BQ632047 BG656185 BU071214 CA843851 
    AI693957 AA971863 BQ778364 BM314444 BQ286290 AA338165 CR607490 BM712445 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NEURL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:        -     -                                   -                     
    SP2:              -                                                         
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for NEURL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEURL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEURL Expression
    About this image


    See NEURL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEURL

    SOURCE GeneReport for Unigene cluster: Hs.594708

    UniProtKB/Swiss-Prot: NEU1A_HUMAN, O76050
    Tissue specificity: Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed
    in an malignant astrocytomas and several neuroectodermal tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including NEURL: 
              Notch Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NEURL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEURL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEURL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEURL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEURL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEURL gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neurl1a1 , 5 neuralized homolog 1A (Drosophila)1, 5 90.82(n)1
    94.34(a)1
      19 (39.39 cM)5
    180111  NM_001163480.11  NP_001156952.11 
     471788205 
    chicken
    (Gallus gallus)
    Aves NEURL1 neuralized homolog (Drosophila) 73.39(n)
    77.61(a)
      423875  NM_001012910.1  NP_001012928.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEURL6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    3(40885070-40981533)
    African clawed frog
    (Xenopus laevis)
    Amphibia neurl-A2 neuralized 73.56(n)    AF419159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neurla1 neuralized homolog a (Drosophila) 65.99(n)
    71.09(a)
      561943  NM_001077558.1  NP_001071026.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta neur3 determination of sensory organ
    precursor cell more
    40(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F10D7.5a3 D. melanogaster finger protein
    neuralized
    31(a)   X(17414408-17423187)   --


    ENSEMBL Gene Tree for NEURL (if available)
    TreeFam Gene Tree for NEURL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEURL gene
    NEURL1B2  
    1 SIMAP similar gene for NEURL using alignment to 2 protein entries:     NEU1A_HUMAN (see all proteins):
    NEURL1B

    NEURL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1837 SNPs in NEURL are shown (see all 1837)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130221481,2
    F--105251829(+) TGTAGC/TGGTGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs124140031,2
    C,H--105251832(+) AGCGGG/TGTGTT 1 -- us2k10--------
    rs1392062991,2
    --105251847(+) CATGTC/GTGAGT 1 -- us2k10--------
    rs1431539321,2
    --105251984(+) CACACA/GTGATC 1 -- us2k10--------
    rs1431185321,2
    C--105252060(+) TGGCT-/GGGG  
      
    /GGGGG
    GTCAC
    1 -- us2k10--------
    rs1890459241,2
    --105252287(+) GGACAA/CCCTGG 1 -- us2k10--------
    rs1474831791,2
    --105252297(+) GTGAAA/CACGAC 1 -- us2k10--------
    rs1392695861,2
    --105252322(+) CCCTCA/CCAGAG 1 -- us2k10--------
    rs1495589341,2
    --105252388(+) GTTCCA/TTATAA 1 -- us2k10--------
    rs1144437981,2
    C,F--105252500(+) CTAGAT/CAATGA 1 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for NEURL (105253735 - 105352309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NEURL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524966CNV Loss19592680
    nsv895981CNV Loss21882294
    esv27747CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603804    OMIM disorders: --

    3 diseases for NEURL:    About MalaCards
    medulloblastoma    astrocytoma    alzheimer's disease


    NEURL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NEURL
    Human Genome Epidemiology (HuGE) Navigator: NEURL (1 document)

    Export disorders for NEURL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEURL gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with NEURL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region. (PubMed id 9519875)1, 2, 3 Nakamura H.... Saya H. (1998)
    2. Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)1, 4 Johnson A.D....Becker L.C. (2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. (PubMed id 11585928)1, 2 Vollrath B.... Fitzgerald K. (2001)
    7. Identification of risk loci with shared effects on fiv e major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1  ....Sullivan P.F. (2013)
    8. Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma. (PubMed id 20847082)1 Teider N....Pomeroy S.L. (2010)
    9. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9148 HGNC: 7761 AceView: NEURL Ensembl:ENSG00000107954 euGenes: HUgn9148
    ECgene: NEURL H-InvDB: NEURL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEURL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEURL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEURL gene:
    Search GeneIP for patents involving NEURL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in NEURL promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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