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Aliases for NEU4 Gene

Aliases for NEU4 Gene

  • Sialidase 4 2 3
  • EC 3.2.1.18 4 63
  • N-Acetyl-Alpha-Neuraminidase 4 4

External Ids for NEU4 Gene

Previous GeneCards Identifiers for NEU4 Gene

  • GC02M238777
  • GC02M239447
  • GC02P242770
  • GC02P243037
  • GC02P243072
  • GC02P242472
  • GC02P242437
  • GC02P242400
  • GC02P234501
  • GC02P242749

Summaries for NEU4 Gene

Entrez Gene Summary for NEU4 Gene

  • The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for NEU4 Gene

NEU4 (Sialidase 4) is a Protein Coding gene. Diseases associated with NEU4 include galactosialidosis. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU3.

UniProtKB/Swiss-Prot for NEU4 Gene

  • May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.

Gene Wiki entry for NEU4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEU4 Gene

Genomics for NEU4 Gene

Regulatory Elements for NEU4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEU4 Gene

Chromosome:
2
Start:
241,808,825 bp from pter
End:
241,817,413 bp from pter
Size:
8,589 bases
Orientation:
Plus strand

Genomic View for NEU4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEU4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEU4 Gene

Proteins for NEU4 Gene

  • Protein details for NEU4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWR8-NEUR4_HUMAN
    Recommended name:
    Sialidase-4
    Protein Accession:
    Q8WWR8
    Secondary Accessions:
    • A8K056
    • J3KNJ5
    • Q96D64

    Protein attributes for NEU4 Gene

    Size:
    484 amino acids
    Molecular mass:
    51572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP34475.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

    Alternative splice isoforms for NEU4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEU4 Gene

Proteomics data for NEU4 Gene at MOPED

Selected DME Specific Peptides for NEU4 Gene

Post-translational modifications for NEU4 Gene

  • According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to the lysosomes via the mannose 6-phosphate receptor
  • Isoform 2 is glycosylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for NEU4 Gene

Protein Domains for NEU4 Gene

Suggested Antigen Peptide Sequences for NEU4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWR8

UniProtKB/Swiss-Prot:

NEUR4_HUMAN :
  • Belongs to the glycosyl hydrolase 33 family.
  • Contains 3 BNR repeats.
Family:
  • Belongs to the glycosyl hydrolase 33 family.
Similarity:
  • Contains 3 BNR repeats.
genes like me logo Genes that share domains with NEU4: view

No data available for Gene Families for NEU4 Gene

Function for NEU4 Gene

Molecular function for NEU4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 3.2.;
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
UniProtKB/Swiss-Prot Function:
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.
UniProtKB/Swiss-Prot Induction:
Down-regulated during monocyte to macrophage differentiation.

Enzyme Numbers (IUBMB) for NEU4 Gene

Gene Ontology (GO) - Molecular Function for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004308 exo-alpha-sialidase activity IDA 14962670
GO:0005515 protein binding IPI 16189514
GO:0052794 exo-alpha-(2->3)-sialidase activity IEA --
GO:0052795 exo-alpha-(2->6)-sialidase activity IEA --
GO:0052796 exo-alpha-(2->8)-sialidase activity IEA --
genes like me logo Genes that share ontologies with NEU4: view
genes like me logo Genes that share phenotypes with NEU4: view

Animal Models for NEU4 Gene

MGI Knock Outs for NEU4:

Animal Model Products

miRNA for NEU4 Gene

miRTarBase miRNAs that target NEU4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEU4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NEU4 Gene

Localization for NEU4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEU4 Gene

Isoform 1: Membrane; Peripheral membrane protein.
Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEU4 Gene COMPARTMENTS Subcellular localization image for NEU4 gene
Compartment Confidence
lysosome 5
vacuole 5
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005764 NOT lysosome IDA 14962670
GO:0019866 organelle inner membrane IDA 14962670
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with NEU4: view

Pathways & Interactions for NEU4 Gene

genes like me logo Genes that share pathways with NEU4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006516 glycoprotein catabolic process IDA 15213228
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006689 ganglioside catabolic process IDA 15213228
genes like me logo Genes that share ontologies with NEU4: view

No data available for SIGNOR curated interactions for NEU4 Gene

Drugs & Compounds for NEU4 Gene

(37) Additional Compounds for NEU4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Galactosylceramide (d18:1/16:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/18:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/18:1(9Z))
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/20:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/22:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
genes like me logo Genes that share compounds with NEU4: view

Transcripts for NEU4 Gene

Unigene Clusters for NEU4 Gene

Sialidase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEU4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEU4 Gene

No ASD Table

Relevant External Links for NEU4 Gene

GeneLoc Exon Structure for
NEU4
ECgene alternative splicing isoforms for
NEU4

Expression for NEU4 Gene

mRNA expression in normal human tissues for NEU4 Gene

mRNA differential expression in normal tissues according to GTEx for NEU4 Gene

This gene is overexpressed in Liver (x14.8) and Colon - Transverse (x6.7).

Protein differential expression in normal tissues from HIPED for NEU4 Gene

This gene is overexpressed in Liver, secretome (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEU4 Gene



SOURCE GeneReport for Unigene cluster for NEU4 Gene Hs.551747

mRNA Expression by UniProt/SwissProt for NEU4 Gene

Q8WWR8-NEUR4_HUMAN
Tissue specificity: Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta.
genes like me logo Genes that share expression patterns with NEU4: view

Protein tissue co-expression partners for NEU4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NEU4 Gene

Orthologs for NEU4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEU4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEU4 35
  • 80.66 (n)
  • 75.53 (a)
NEU4 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neu4 35
  • 74.83 (n)
  • 72.18 (a)
Neu4 16
Neu4 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neu4 35
  • 74.81 (n)
  • 72.63 (a)
oppossum
(Monodelphis domestica)
Mammalia NEU4 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEU4 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEU4 35
  • 66.06 (n)
  • 58.03 (a)
NEU4 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEU4 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486976 35
  • 56.25 (n)
  • 50.33 (a)
zebrafish
(Danio rerio)
Actinopterygii neu4 35
  • 55.13 (n)
  • 48.8 (a)
neu4 36
  • 48 (a)
OneToOne
Species with no ortholog for NEU4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEU4 Gene

ENSEMBL:
Gene Tree for NEU4 (if available)
TreeFam:
Gene Tree for NEU4 (if available)

Paralogs for NEU4 Gene

Paralogs for NEU4 Gene

genes like me logo Genes that share paralogs with NEU4: view

Variants for NEU4 Gene

Sequence variations from dbSNP and Humsavar for NEU4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_067458 -

Structural Variations from Database of Genomic Variants (DGV) for NEU4 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4497n71 CNV Loss 21882294
nsv876254 CNV Loss 21882294
nsv876255 CNV Loss 21882294
nsv10232 CNV Gain+Loss 18304495
dgv4499n71 CNV Gain 21882294
esv4746 CNV Deletion 18987735
esv2664751 CNV Deletion 23128226
esv989515 CNV Insertion 20482838
nsv470533 CNV Loss 18288195

Variation tolerance for NEU4 Gene

Residual Variation Intolerance Score: 98.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEU4 Gene

HapMap Linkage Disequilibrium report
NEU4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU4 Gene

Disorders for NEU4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEU4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
galactosialidosis
  • cathepsin a
- elite association
Search NEU4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEU4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEU4
genes like me logo Genes that share disorders with NEU4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEU4 Gene

Publications for NEU4 Gene

  1. Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. (PMID: 19506080) Shiozaki K. … Miyagi T. (J. Biol. Chem. 2009) 23 67
  2. Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. (PMID: 18270209) Seyrantepe V. … Pshezhetsky A.V. (Hum. Mol. Genet. 2008) 23 67
  3. Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio). (PMID: 17708749) Manzoni M. … Monti E. (Biochem. J. 2007) 23 67
  4. Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. (PMID: 16835219) Liang F. … Pshezhetsky A.V. (J. Biol. Chem. 2006) 23 67
  5. Evidence for mitochondrial localization of a novel human sialidase (NEU4). (PMID: 15847605) Yamaguchi K. … Miyagi T. (Biochem. J. 2005) 23 67

Products for NEU4 Gene

Sources for NEU4 Gene

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