NEU4 Gene
protein-coding GIFtS: 53
GCID: GC02P242770
|
|
sialidase 4
| |
Aliases
for NEU4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sialidase 41 2 | | N-Acetyl-Alpha-Neuraminidase 42 3 | | EC 3.2.1.183 8 | | Neuraminidase 42 | | Sialidase-41 |
Export aliases for NEU4 gene to outside databasesPrevious GC identifers: GC02M238777 GC02M239447 GC02P243037 GC02P243072 GC02P242472 GC02P242437 GC02P242400 GC02P234501 |
Summaries
for NEU4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEU4:
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acidresidues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides.Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. (provided byRefSeq, Nov 2009)
UniProtKB/Swiss-Prot: NEUR4_HUMAN, Q8WWR8Function: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards syntheticsubstrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broadsubstrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids
Gene Wiki entry for NEU4
|
Genomic Views
for NEU4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEU4 gene promoter:
RFX1 RP58 AML1a Olf-1 AP-4 LCR-F1 E47 HEN1 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEU4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEU4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3NEU4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P242770: view genomic region
(about GC identifiers)
Start:
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242,749,920 bp from pter |
End:
|
242,758,739 bp from pter |
Size:
|
8,820 bases |
Orientation:
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plus strand |
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Proteins
for NEU4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NEUR4_HUMAN, Q8WWR8 (See
protein sequence)Recommended Name: Sialidase-4 Size: 484 amino acids; 51572 Da
Subcellular location: Isoform 1: Membrane; Peripheral membrane protein
Subcellular location: Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble,N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predictedfrom the sequence
Sequence caution: Sequence=AAP34475.1; Type=Frameshift; Positions=291;
Secondary accessions: A8K056 Q96D64Alternative splicing: 2 isoforms: Q8WWR8-1 Q8WWR8-2 Explore the universe of human proteins at neXtProt for NEU4: NX_Q8WWR8
Post-translational modifications:
According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to thelysosomes via the mannose 6-phosphate receptor1
Isoform 2 is glycosylated (PubMed:15213228)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWR8
2 DME Specific Peptides for NEU4 (Q8WWR8)
NEU4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001161071.1 NP_001161072.1 NP_001161073.1 NP_001161074.1 NP_542779.2
ENSEMBL proteins: ENSP00000385402 ENSP00000397167 ENSP00000384804 ENSP00000394769 ENSP00000397860 ENSP00000385149 ENSP00000375830 ENSP00000320318 ENSP00000412688 ENSP00000398571 ENSP00000406678 ENSP00000388707 ENSP00000396197 Reactome Protein details: Q8WWR8
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NEU4 for ontologies About GeneDecksing
NEU4 Antibody Products:
Assay Products for NEU4: |
Protein
Domains /
Families
for NEU4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEU4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWR8ProtoNet protein and cluster: Q8WWR8 UniProtKB/Swiss-Prot: NEUR4_HUMAN, Q8WWR8Similarity: Belongs to the glycosyl hydrolase 33 familySimilarity: Contains 3 BNR repeats |
Function
for NEU4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NEUR4_HUMAN, Q8WWR8Function: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards syntheticsubstrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broadsubstrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipidsCatalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialicacid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substratesBiophysicochemical properties: pH dependence: Optimum pH is 3.2;Induction: Down-regulated during monocyte to macrophage differentiationEnzyme Number (IUBMB): EC 3.2.1.181 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NEU4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU4 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NEU4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Neu4tm1Avps for NEU4
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Neu4):
NEU4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NEU4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | Metabolism | | | 3 | Other glycan degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for NEU4
2 
Kegg Pathways (Kegg details for NEU4):
NEU4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEU4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for NEU4 (Q8WWR81, 2, 3 ENSP000003851494) via UniProtKB, MINT, STRING, and/or I2D (see all 10)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RBPMS | Q930622, 3, ENSP000003401764 | MINT-68006 I2D:
score=4 STRING: ENSP00000340176 | | RHOXF2 | Q9BQY42, 3, ENSP000003604414 | MINT-67256 I2D:
score=4 STRING: ENSP00000360441 | | PLSCR1 | O151621, 2, 3, ENSP000003454944 | EBI-746964,EBI-740019 MINT-66956 I2D:
score=5 STRING: ENSP00000345494 | | MDFI | Q997501, 3, ENSP000002303214 | EBI-746964,EBI-724076 I2D:
score=2 STRING: ENSP00000230321 | | ARSA | ENSP000002161244 | STRING: ENSP00000216124 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006665 | sphingolipid metabolic process |
TAS | -- | | GO:0006687 | glycosphingolipid metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NEU4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEU4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NEU4
10/58 HMDB Compounds for NEU4 (see all 58) About this table
Search CenterWatch for drugs/clinical trials and news about NEU4 / NEUR4
|
Transcripts
for NEU4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NEU4 gene (5 alternative transcripts): NM_001167599.1 NM_001167600.1 NM_001167601.1 NM_001167602.1 NM_080741.2 Unigene Cluster for NEU4: Sialidase 4 Hs.551747 [show with all ESTs]Unigene Representative Sequence: AK09699217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000407683(uc010fzr.3 uc002wcm.3) ENST00000415936 ENST00000405370
ENST00000476542 ENST00000435855 ENST00000406147 ENST00000423583 ENST00000404257(uc002wcn.2 uc002wcp.2)
ENST00000391969(uc002wco.2) ENST00000325935 ENST00000435934 ENST00000435894
ENST00000426032 ENST00000420288 ENST00000494678 ENST00000488997 ENST00000428592
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): NEU4 (NM_080741) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEU4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU4 |
Additional cDNA sequence: AJ277883.1 AK025617.1 AK091038.1 AK096992.1 AK289421.1 AK290076.1 AK298403.1 AK300969.1 AY203952.1 BC012899.1 BC063465.1 BC067780.1 BC105974.1 BC117214.1 6 DOTS entries: DT.92046342 DT.75171189 DT.100747786 DT.99930482 DT.120973961 DT.99954020 24/38 AceView cDNA sequences (see all 38): AX746745 BC012899 BI754607 AK096992 NM_080741 AK091038 BU740754 AJ277883 AI564945 AI272360 AY203952 BF348126 BF346287 BF529996 BX279923 BM925752 BG914073 AW002103 AK025617 BQ651855 BM727519 BG820306 BG910455 BG910459
GeneLoc Exon Structure
|
Expression
for NEU4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NEU4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCTTGGGT
About this image
See NEU4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEU4
SOURCE GeneReport for Unigene cluster: Hs.551747
UniProtKB/Swiss-Prot: NEUR4_HUMAN, Q8WWR8Tissue specificity: Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta
SABiosciences Expression via Pathway-Focused PCR Array including NEU4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEU4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEU4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEU4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEU4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU4 |
Orthologs
for NEU4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NEU4 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for NEU4 (if available)
TreeFam Gene Tree for NEU4 (if available) |
Paralogs
for NEU4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NEU4 gene
- NEU22 NEU32
2 SIMAP similar genes for NEU4 using alignment to 12 protein entries: NEUR4_HUMAN (see all proteins):NEU3 NEU2
NEU4 for paralogs About GeneDecksing
|
Genomic Variants
for NEU4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NEU4 (242749920 - 242758739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for NEU4
14 CNVs: 8968 32401 50441 50442 2429 50443 50444 34635 50440 30115 8969 50439 34658 31025
1 Indel: 42024 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEU4 |
|
Disorders
/ Diseases
for NEU4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEU4 for disorders About GeneDecksing
OMIM gene information: 608527
OMIM disorders: --
7  diseases for NEU4: About MalaCardsclear cell adenocarcinoma ovarian clear cell adenocarcinoma galactosialidosis sialidosis
influenza adenocarcinoma neuronitis
Export disorders for NEU4 gene to outside databases
|
Publications
for NEU4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NEU4 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NEU4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. (PubMed id 15213228)1, 2, 9 Seyrantepe V....Pshezhetsky A.V. (2004)
- Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. (PubMed id 14962670)1, 2, 9 Monti E.... Borsani G. (2004)
- Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. (PubMed id 15885103)1, 2, 9 Stamatos N.M....Pshezhetsky A.V. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sialidase NEU4 hydrolyzes polysialic acids of neural c ell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. (PubMed id 22393058)1 Takahashi K....Miyagi T. (2012)
- NEU4L sialidase overexpression promotes b-catenin sign aling in neuroblastoma cells, enhancing stem-like malignant cell growth. (PubMed id 22287118)1 Tringali C....Venerando B. (2012)
- Regulation of sialyl Lewis antigen expression in colo n cancer cells by sialidase NEU4. (PubMed id 21521691)1 Shiozaki K....Miyagi T. (2011)
|
External Searches for NEU4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEU4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEU4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NEU4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NEU4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NEU4 gene:
Search GeneIP for patents involving NEU4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NEU4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NEU4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEU4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEU4 | | | OriGene Protein Over-expression Lysate for NEU4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NEU4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEU4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NEU4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NEU4 | | OriGene Custom Protein Services for NEU4 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEU4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEU4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEU4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEU4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEU4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEU4 |
| |
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| | | | Search Tocris compounds for NEU4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU4 |
|  |  |  | | | | ThermoFisher Antibodies for NEU4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU4 |
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