Aliases for NEU4 Gene
External Ids for NEU4 Gene
Previous GeneCards Identifiers for NEU4 Gene
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]
GeneCards Summary for NEU4 Gene
NEU4 (Neuraminidase 4 (Sialidase)) is a Protein Coding gene. Diseases associated with NEU4 include Galactosialidosis. Among its related pathways are Sphingolipid metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU3.
UniProtKB/Swiss-Prot for NEU4 Gene
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.