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Aliases for NEU4 Gene

Aliases for NEU4 Gene

  • Neuraminidase 4 2 3 5
  • N-Acetyl-Alpha-Neuraminidase 4 3 4
  • Neuraminidase 4 (Sialidase) 2 3
  • EC 3.2.1.18 4 61
  • Sialidase 4 2
  • Sialidase-4 3

External Ids for NEU4 Gene

Previous GeneCards Identifiers for NEU4 Gene

  • GC02M238777
  • GC02M239447
  • GC02P242770
  • GC02P243037
  • GC02P243072
  • GC02P242472
  • GC02P242437
  • GC02P242400
  • GC02P234501
  • GC02P242749

Summaries for NEU4 Gene

Entrez Gene Summary for NEU4 Gene

  • The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for NEU4 Gene

NEU4 (Neuraminidase 4) is a Protein Coding gene. Diseases associated with NEU4 include Galactosialidosis. Among its related pathways are Sphingolipid metabolism and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU3.

UniProtKB/Swiss-Prot for NEU4 Gene

  • May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.

Gene Wiki entry for NEU4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEU4 Gene

Genomics for NEU4 Gene

Regulatory Elements for NEU4 Gene

Enhancers for NEU4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G241802 1.3 Ensembl ENCODE 24.7 -2.7 -2672 6.7 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 KDM4B ZNF263 ENSG00000224272 NEU4 D2HGDH GAL3ST2 PIR47886
GH02G241858 1.4 Ensembl ENCODE dbSUPER 16.6 +50.9 50919 3.1 HDGF TBP PKNOX1 TBL1XR1 ZNF473 ZNF48 GLIS2 EGR1 HSF1 ZNF207 ENSG00000224272 NEU4 ENSG00000234793 D2HGDH ENSG00000215023 LOC285095 LINC01237 ENSG00000235151 PDCD1 RTP5
GH02G241842 1.1 ENCODE dbSUPER 15.4 +34.4 34360 1.3 BCOR PTBP1 BACH1 MAX ZNF48 ZBTB40 POLR2A EED ZNF143 NR2F6 NEU4 LOC285095 ENSG00000235151 ENSG00000224272
GH02G241867 1.2 Ensembl ENCODE dbSUPER 11.7 +59.3 59328 3.4 PKNOX1 BMI1 ZIC2 ZFHX2 GLIS2 EGR1 EZH2 EGR2 RFX1 NRF1 ENSG00000234793 D2HGDH NEU4 ENSG00000215023 LINC01237 ENSG00000235151 LOC285095 ENSG00000224272 BOK RTP5
GH02G241788 1 FANTOM5 dbSUPER 13.3 -20.0 -20036 0.4 CTCF PKNOX1 MTA2 CBFB NR2F1 JUNB EBF1 DPF2 RAD21 TBX21 D2HGDH ENSG00000224272 NEU4 ENSG00000234793 RTP5 ATG4B ENSG00000215023 GAL3ST2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEU4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEU4 Gene

Chromosome:
2
Start:
241,808,825 bp from pter
End:
241,817,413 bp from pter
Size:
8,589 bases
Orientation:
Plus strand

Genomic View for NEU4 Gene

Genes around NEU4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEU4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEU4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEU4 Gene

Proteins for NEU4 Gene

  • Protein details for NEU4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWR8-NEUR4_HUMAN
    Recommended name:
    Sialidase-4
    Protein Accession:
    Q8WWR8
    Secondary Accessions:
    • A8K056
    • J3KNJ5
    • Q96D64

    Protein attributes for NEU4 Gene

    Size:
    484 amino acids
    Molecular mass:
    51572 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP34475.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

    Alternative splice isoforms for NEU4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEU4 Gene

Selected DME Specific Peptides for NEU4 Gene

Q8WWR8:
  • HRSMNPCP
  • TFAVGPGH

Post-translational modifications for NEU4 Gene

  • According to PubMed:15213228, phosphorylation of mannose residues may ensure efficient transport of isoform 2 to the lysosomes via the mannose 6-phosphate receptor.
  • Isoform 2 is glycosylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NEU4 Gene

Protein Domains for NEU4 Gene

Suggested Antigen Peptide Sequences for NEU4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWR8

UniProtKB/Swiss-Prot:

NEUR4_HUMAN :
  • Belongs to the glycosyl hydrolase 33 family.
Family:
  • Belongs to the glycosyl hydrolase 33 family.
genes like me logo Genes that share domains with NEU4: view

No data available for Gene Families for NEU4 Gene

Function for NEU4 Gene

Molecular function for NEU4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 3.2.;
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
UniProtKB/Swiss-Prot Function:
May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids.
UniProtKB/Swiss-Prot Induction:
Down-regulated during monocyte to macrophage differentiation.

Enzyme Numbers (IUBMB) for NEU4 Gene

Gene Ontology (GO) - Molecular Function for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004308 exo-alpha-sialidase activity TAS --
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0052794 exo-alpha-(2->3)-sialidase activity IEA --
genes like me logo Genes that share ontologies with NEU4: view
genes like me logo Genes that share phenotypes with NEU4: view

Animal Models for NEU4 Gene

MGI Knock Outs for NEU4:

Animal Model Products

miRNA for NEU4 Gene

miRTarBase miRNAs that target NEU4

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEU4 Gene

Localization for NEU4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEU4 Gene

Isoform 1: Membrane; Peripheral membrane protein.
Isoform 2: Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEU4 gene
Compartment Confidence
lysosome 5
mitochondrion 4
nucleus 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005764 NOT lysosome IDA 14962670
GO:0016020 membrane IEA --
GO:0019866 organelle inner membrane IDA 14962670
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with NEU4: view

Pathways & Interactions for NEU4 Gene

genes like me logo Genes that share pathways with NEU4: view

Gene Ontology (GO) - Biological Process for NEU4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006516 glycoprotein catabolic process IDA 15213228
GO:0006629 lipid metabolic process IEA --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006689 ganglioside catabolic process IDA 15213228
genes like me logo Genes that share ontologies with NEU4: view

No data available for SIGNOR curated interactions for NEU4 Gene

Drugs & Compounds for NEU4 Gene

(1) Drugs for NEU4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(36) Additional Compounds for NEU4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Galactosylceramide (d18:1/16:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/18:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/18:1(9Z))
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/20:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
Galactosylceramide (d18:1/22:0)
  • a-GalCer
  • alpha-GalCer
  • Cerebroside
  • D-Galactosyl-N-acylsphingosine
  • D-Galactosylceramide
genes like me logo Genes that share compounds with NEU4: view

Transcripts for NEU4 Gene

Unigene Clusters for NEU4 Gene

Sialidase 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEU4 Gene

No ASD Table

Relevant External Links for NEU4 Gene

GeneLoc Exon Structure for
NEU4
ECgene alternative splicing isoforms for
NEU4

Expression for NEU4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEU4 Gene

mRNA differential expression in normal tissues according to GTEx for NEU4 Gene

This gene is overexpressed in Liver (x14.8) and Colon - Transverse (x6.7).

Protein differential expression in normal tissues from HIPED for NEU4 Gene

This gene is overexpressed in Liver, secretome (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEU4 Gene



Protein tissue co-expression partners for NEU4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEU4 Gene:

NEU4

SOURCE GeneReport for Unigene cluster for NEU4 Gene:

Hs.551747

mRNA Expression by UniProt/SwissProt for NEU4 Gene:

Q8WWR8-NEUR4_HUMAN
Tissue specificity: Ubiquitous with higher expression in heart, skeletal muscle, liver and placenta.

Evidence on tissue expression from TISSUES for NEU4 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with NEU4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEU4 Gene

Orthologs for NEU4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEU4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEU4 34 35
  • 80.66 (n)
mouse
(Mus musculus)
Mammalia Neu4 34 16 35
  • 74.83 (n)
rat
(Rattus norvegicus)
Mammalia Neu4 34
  • 74.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NEU4 35
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEU4 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEU4 34 35
  • 66.06 (n)
lizard
(Anolis carolinensis)
Reptilia NEU4 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486976 34
  • 56.25 (n)
zebrafish
(Danio rerio)
Actinopterygii neu4 34 35
  • 55.13 (n)
Species where no ortholog for NEU4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEU4 Gene

ENSEMBL:
Gene Tree for NEU4 (if available)
TreeFam:
Gene Tree for NEU4 (if available)

Paralogs for NEU4 Gene

Paralogs for NEU4 Gene

genes like me logo Genes that share paralogs with NEU4: view

Variants for NEU4 Gene

Sequence variations from dbSNP and Humsavar for NEU4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000377147 -- 241,817,512(+) TTAGC(A/T)AAGCT downstream-variant-500B
rs1000453104 -- 241,809,587(+) CAGAT(A/G)GGCCC intron-variant, upstream-variant-2KB
rs1000825328 -- 241,814,559(+) GTGCC(C/T)TCGCT reference, synonymous-codon
rs1000858144 -- 241,810,018(+) GGGGA(C/T)ACGAG intron-variant, upstream-variant-2KB
rs1000905827 -- 241,809,774(+) GTGAA(A/G)TCTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEU4 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
dgv4200n100 CNV loss 25217958
dgv4201n100 CNV gain 25217958
esv2664751 CNV deletion 23128226
esv4746 CNV loss 18987735
esv989515 CNV insertion 20482838
nsv1002941 CNV gain 25217958
nsv1006733 CNV gain 25217958
nsv10232 CNV gain+loss 18304495
nsv470533 CNV loss 18288195
nsv584982 CNV loss 21841781
nsv584991 CNV loss 21841781
nsv584996 CNV gain 21841781
nsv955301 CNV deletion 24416366
nsv997984 CNV gain 25217958

Variation tolerance for NEU4 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEU4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEU4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU4 Gene

Disorders for NEU4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEU4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
galactosialidosis
  • cathepsin a deficiency of
- elite association - COSMIC cancer census association via MalaCards
Search NEU4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEU4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEU4
genes like me logo Genes that share disorders with NEU4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEU4 Gene

Publications for NEU4 Gene

  1. Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. (PMID: 15885103) Stamatos N.M. … Pshezhetsky A.V. (FEBS J. 2005) 3 4 22 64
  2. Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. (PMID: 15213228) Seyrantepe V. … Pshezhetsky A.V. (J. Biol. Chem. 2004) 3 4 22 64
  3. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. (PMID: 14962670) Monti E. … Borsani G. (Genomics 2004) 3 4 22 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NEU4 Gene

Sources for NEU4 Gene

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