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Aliases for NEU3 Gene

Aliases for NEU3 Gene

  • Neuraminidase 3 (Membrane Sialidase) 2 3 5
  • Sialidase 3 (Membrane Sialidase) 2 3
  • N-Acetyl-Alpha-Neuraminidase 3 3 4
  • Ganglioside Sialidase 3 4
  • Membrane Sialidase 3 4
  • EC 3.2.1.18 4 63
  • Neuraminidase 3 3
  • SIAL3 3

External Ids for NEU3 Gene

Previous GeneCards Identifiers for NEU3 Gene

  • GC11P077026
  • GC11P076238
  • GC11P074921
  • GC11P074425
  • GC11P074376
  • GC11P074699
  • GC11P070997

Summaries for NEU3 Gene

Entrez Gene Summary for NEU3 Gene

  • This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEU3 Gene

NEU3 (Neuraminidase 3 (Membrane Sialidase)) is a Protein Coding gene. Diseases associated with NEU3 include galactosialidosis and angiokeratoma. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU4.

UniProtKB/Swiss-Prot for NEU3 Gene

  • Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.

Gene Wiki entry for NEU3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEU3 Gene

Genomics for NEU3 Gene

Regulatory Elements for NEU3 Gene

Promoters for NEU3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEU3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEU3 Gene

Chromosome:
11
Start:
74,988,134 bp from pter
End:
75,018,893 bp from pter
Size:
30,760 bases
Orientation:
Plus strand

Genomic View for NEU3 Gene

Genes around NEU3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEU3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEU3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEU3 Gene

Proteins for NEU3 Gene

  • Protein details for NEU3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ49-NEUR3_HUMAN
    Recommended name:
    Sialidase-3
    Protein Accession:
    Q9UQ49
    Secondary Accessions:
    • A8K327
    • Q9NQE1

    Protein attributes for NEU3 Gene

    Size:
    428 amino acids
    Molecular mass:
    48252 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEU3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEU3 Gene

Proteomics data for NEU3 Gene at MOPED

Selected DME Specific Peptides for NEU3 Gene

Post-translational modifications for NEU3 Gene

  • Ubiquitination at Lys 44, Lys 74, Lys 154, Lys 301, and Lys 426
  • Modification sites at PhosphoSitePlus

Other Protein References for NEU3 Gene

Domains & Families for NEU3 Gene

Protein Domains for NEU3 Gene

Suggested Antigen Peptide Sequences for NEU3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ49

UniProtKB/Swiss-Prot:

NEUR3_HUMAN :
  • Belongs to the glycosyl hydrolase 33 family.
  • Contains 3 BNR repeats.
Family:
  • Belongs to the glycosyl hydrolase 33 family.
Similarity:
  • Contains 3 BNR repeats.
genes like me logo Genes that share domains with NEU3: view

No data available for Gene Families for NEU3 Gene

Function for NEU3 Gene

Molecular function for NEU3 Gene

GENATLAS Biochemistry:
neuraminidase 3,membrane sialidase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 3.8.;
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
UniProtKB/Swiss-Prot Function:
Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.

Enzyme Numbers (IUBMB) for NEU3 Gene

Gene Ontology (GO) - Molecular Function for NEU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016997 alpha-sialidase activity IDA 12730204
genes like me logo Genes that share ontologies with NEU3: view
genes like me logo Genes that share phenotypes with NEU3: view

Animal Models for NEU3 Gene

MGI Knock Outs for NEU3:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEU3 Gene

Localization for NEU3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEU3 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEU3 Gene COMPARTMENTS Subcellular localization image for NEU3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
lysosome 2
nucleus 2
vacuole 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NEU3 Gene

Pathways & Interactions for NEU3 Gene

genes like me logo Genes that share pathways with NEU3: view

Interacting Proteins for NEU3 Gene

Gene Ontology (GO) - Biological Process for NEU3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006689 ganglioside catabolic process IDA 10861246
GO:0009313 oligosaccharide catabolic process IDA 10861246
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with NEU3: view

No data available for SIGNOR curated interactions for NEU3 Gene

Drugs & Compounds for NEU3 Gene

(1) Drugs for NEU3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(55) Additional Compounds for NEU3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ganglioside GM1 (18:1/12:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/16:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (18:1/20:0)
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2)-O-[O-b-D-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1)]-O-b-D-galactopyranosyl-(1)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-a-neuraminosyl)-(2->3)-O-[O-b-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-b-D-galactopyranosyl-(1->4)]-O-b-D-galactopyranosyl-(1->4)-b-D-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2)-O-[O-beta-delta-galactopyranosyl-(1)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1)]-O-beta-delta-galactopyranosyl-(1)-beta-delta-glucopyranosyl]-Ceramide
  • 1-O-[O-(N-Acetyl-alpha-neuraminosyl)-(2->3)-O-[O-beta-D galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-delta-galactopyranosyl-(1->4)]-O-beta-delta-galactopyranosyl-(1->4)-beta-delta-glucopyranosyl]-Ceramide
  • D-Galactosyl-1,3-beta-N-acetyl-D galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-Nacylsphingosine
104443-62-1
Ganglioside GM1 (d18:0/12:0)
Ganglioside GM1 (d18:0/14:0)
genes like me logo Genes that share compounds with NEU3: view

Transcripts for NEU3 Gene

Unigene Clusters for NEU3 Gene

Sialidase 3 (membrane sialidase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEU3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for NEU3 Gene

GeneLoc Exon Structure for
NEU3
ECgene alternative splicing isoforms for
NEU3

Expression for NEU3 Gene

mRNA expression in normal human tissues for NEU3 Gene

mRNA differential expression in normal tissues according to GTEx for NEU3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for NEU3 Gene

This gene is overexpressed in Plasma (29.0), Esophagus (28.5), and Frontal cortex (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEU3 Gene



SOURCE GeneReport for Unigene cluster for NEU3 Gene Hs.191074

mRNA Expression by UniProt/SwissProt for NEU3 Gene

Q9UQ49-NEUR3_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.
genes like me logo Genes that share expression patterns with NEU3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for NEU3 Gene

Orthologs for NEU3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEU3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEU3 35
  • 99.71 (n)
  • 99.35 (a)
NEU3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEU3 36
  • 82 (a)
OneToOne
NEU3 35
  • 87.05 (n)
  • 83.02 (a)
dog
(Canis familiaris)
Mammalia NEU3 35
  • 88.53 (n)
  • 84.42 (a)
NEU3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neu3 36
  • 68 (a)
OneToOne
Neu3 35
  • 77.62 (n)
  • 68.59 (a)
Neu3 16
rat
(Rattus norvegicus)
Mammalia Neu3 35
  • 77.38 (n)
  • 68.35 (a)
chicken
(Gallus gallus)
Aves NEU3 35
  • 58.17 (n)
  • 55.4 (a)
NEU3 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496715 35
  • 58.83 (n)
  • 52.22 (a)
zebrafish
(Danio rerio)
Actinopterygii neu3.2 36
  • 45 (a)
OneToMany
neu3.3 36
  • 43 (a)
OneToMany
neu3.4 36
  • 47 (a)
OneToMany
neu3.5 36
  • 42 (a)
OneToMany
neu3.1 35
  • 54.99 (n)
  • 55.35 (a)
Species with no ortholog for NEU3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEU3 Gene

ENSEMBL:
Gene Tree for NEU3 (if available)
TreeFam:
Gene Tree for NEU3 (if available)

Paralogs for NEU3 Gene

Paralogs for NEU3 Gene

(3) SIMAP similar genes for NEU3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NEU3: view

Variants for NEU3 Gene

Sequence variations from dbSNP and Humsavar for NEU3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7115499 - 74,994,557(+) GTTCC(A/G)GCAGG reference, missense
rs544115 -- 74,994,651(-) CTCGT(A/G)GAACG reference, synonymous-codon
rs997465 -- 74,988,148(-) CAAAC(A/G)CCAAT upstream-variant-2KB
rs1659690 -- 74,990,449(-) aaacc(A/C)ggaga intron-variant
rs2465289 -- 74,998,144(+) gtcag(G/T)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEU3 Gene

Variant ID Type Subtype PubMed ID
nsv832210 CNV Gain+Loss 17160897

Variation tolerance for NEU3 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEU3 Gene

HapMap Linkage Disequilibrium report
NEU3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU3 Gene

Disorders for NEU3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NEU3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
galactosialidosis
  • cathepsin a
angiokeratoma
  • angiokeratoma of skin
- elite association - COSMIC cancer census association via MalaCards
Search NEU3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEU3

Genetic Association Database (GAD)
NEU3
Human Genome Epidemiology (HuGE) Navigator
NEU3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEU3
genes like me logo Genes that share disorders with NEU3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEU3 Gene

Publications for NEU3 Gene

  1. Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. (PMID: 10405317) Wada T. … Miyagi T. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells. (PMID: 18339327) Jin U.H. … Kim C.H. (Biochim. Biophys. Acta 2008) 3 23
  3. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. (PMID: 17334392) Wada T. … Miyagi T. (Oncogene 2007) 3 23
  4. Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis. (PMID: 17827720) Azuma Y. … Matsumoto K. (Biol. Pharm. Bull. 2007) 3 23
  5. Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. (PMID: 16428383) Ueno S. … Miyagi T. (J. Biol. Chem. 2006) 3 23

Products for NEU3 Gene

Sources for NEU3 Gene

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