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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEU3 Gene

protein-coding   GIFtS: 58
GCID: GC11P074699

Sialidase 3 (Membrane Sialidase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sialidase 3 (Membrane Sialidase)1 2     EC 3.2.1.183 8
Ganglioside Sialidase2 3     SIAL32 5
Membrane Sialidase2 3     Neuraminidase 32
N-Acetyl-Alpha-Neuraminidase 32 3     sialidase-32

External Ids:    HGNC: 77601   Entrez Gene: 108252   Ensembl: ENSG000001621397   OMIM: 6046175   UniProtKB: Q9UQ493   

Export aliases for NEU3 gene to outside databases

Previous GC identifers: GC11P077026 GC11P076238 GC11P074921 GC11P074425 GC11P074376 GC11P070997


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEU3 Gene:
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from
glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for
gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. (provided by RefSeq,
Jul 2008)

GeneCards Summary for NEU3 Gene: 
NEU3 (sialidase 3 (membrane sialidase)) is a protein-coding gene. Diseases associated with NEU3 include galactosialidosis, and mucolipidosis, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include catalytic activity and exo-alpha-(2->6)-sialidase activity. An important paralog of this gene is NEU2.

UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
Function: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound
sialyl glycoconjugates

Gene Wiki entry for NEU3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEU3 gene promoter:
         HOXA9B   HOXA9   AML1a   RREB-1   Pax-2   MyoD   Pax-2a   Ik-2   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEU3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEU3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEU3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5

NEU3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEU3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P074699:  view genomic region     (about GC identifiers)

Start:
74,699,179 bp from pter      End:
74,729,938 bp from pter
Size:
30,760 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49 (See protein sequence)
Recommended Name: Sialidase-3  
Size: 428 amino acids; 48252 Da
Subcellular location: Membrane; Peripheral membrane protein
Sequence caution: Sequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9NQE1

Explore the universe of human proteins at neXtProt for NEU3: NX_Q9UQ49

Explore proteomics data for NEU3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQ49

  • 2 DME Specific Peptides for NEU3 (Q9UQ49)
     TFAVGPGH  GCQGSVVS 

    NEU3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEU3 Protein Expression
    REFSEQ proteins: NP_006647.3  
    ENSEMBL proteins: 
     ENSP00000294064   ENSP00000432097   ENSP00000434474   ENSP00000436540   ENSP00000434907  
     ENSP00000436118   ENSP00000434754   ENSP00000445591   ENSP00000439908  
    Reactome Protein details: Q9UQ49
    Human Recombinant Protein Products for NEU3: 
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    OriGene Protein Over-expression Lysate for NEU3
    OriGene MassSpec for NEU3 
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    Novus Biologicals NEU3 Protein
    Novus Biologicals NEU3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10405317

    NEU3 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for NEU3 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011040 Sialidases
     IPR026856 Sialidase_fam
     IPR026944 Sialidase-3

    Graphical View of Domain Structure for InterPro Entry Q9UQ49

    ProtoNet protein and cluster: Q9UQ49

    UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
    Similarity: Belongs to the glycosyl hydrolase 33 family
    Similarity: Contains 3 BNR repeats


    NEU3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUR3_HUMAN, Q9UQ49
    Function: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound
    sialyl glycoconjugates
    Catalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal
    sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
    Biophysicochemical properties: pH dependence: Optimum pH is 3.8;

         Genatlas biochemistry entry for NEU3:
    neuraminidase 3,membrane sialidase

         Enzyme Number (IUBMB): EC 3.2.1.181 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS10405317
    GO:0004308exo-alpha-sialidase activity ----
    GO:0016997alpha-sialidase activity IDA12730204
    GO:0052794exo-alpha-(2->3)-sialidase activity IEA--
    GO:0052795exo-alpha-(2->6)-sialidase activity IEA--
         
    NEU3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Neu3):
     homeostasis/metabolism  normal  tumorigenesis 

    NEU3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neu3tm1Yamk for NEU3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEU3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEU3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEU3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEU3 

    miRNA
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    hsa-miR-1283 hsa-miR-125a-3p hsa-miR-3688-3p hsa-miR-1255a hsa-miR-1256 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEU3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEU3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Glycosphingolipid metabolism0.55
    Sphingolipid metabolism0.63
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Other glycan degradation
    Other glycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for NEU3
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for NEU3):
        Other glycan degradation
    Sphingolipid metabolism


    NEU3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEU3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for NEU3 (Q9UQ493 ENSP000002940644) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTRK1P046293I2D: score=1 
    ARSAENSP000002161244STRING: ENSP00000216124
    GAL3ST1ENSP000003432344STRING: ENSP00000343234
    GALCENSP000002613044STRING: ENSP00000261304
    GLAENSP000002185164STRING: ENSP00000218516
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IDA12730204
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006689ganglioside catabolic process TAS10405317
    GO:0044281small molecule metabolic process TAS--

    NEU3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEU3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NEU3 (NEUR3)

    10/99 HMDB Compounds for NEU3 (see all 99)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ganglioside GM1 (d18:0/12:0) --12486725
    Ganglioside GM1 (d18:0/14:0) --12486725
    Ganglioside GM1 (d18:0/16:0) --12486725
    Ganglioside GM1 (d18:0/18:0) --12486725
    Ganglioside GM1 (d18:0/18:1(11Z)) --12486725
    Ganglioside GM1 (d18:0/18:1(9Z)) --12486725
    Ganglioside GM1 (d18:0/20:0) --12486725
    Ganglioside GM1 (d18:0/22:0) --12486725
    Ganglioside GM1 (d18:0/22:1(13Z)) --12486725
    Ganglioside GM1 (d18:0/23:0) --12486725

    4 Novoseek inferred chemical compound relationships for NEU3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioside 83.3 16 15179041 (3), 10405317 (2), 1879535 (1), 12164932 (1) (see all 11)
    lactosylceramide 73.5 2 16428383 (1), 19215228 (1)
    glycolipid 52.6 1 16428383 (1)
    tyrosine 11.7 7 16241905 (1), 17334392 (1)

    Search CenterWatch for drugs/clinical trials and news about NEU3 / NEUR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEU3 gene: 
    NM_006656.5  

    Unigene Cluster for NEU3:

    Sialidase 3 (membrane sialidase)
    Hs.191074  [show with all ESTs]
    Unigene Representative Sequence: Y18563
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294064(uc001ovv.3 uc001ovw.3 uc010rrl.2) ENST00000531509
    ENST00000529024 ENST00000526068 ENST00000532963 ENST00000531619 ENST00000534628
    ENST00000544263 ENST00000545272
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NEU3:
    hsa-miR-1283 hsa-miR-125a-3p hsa-miR-3688-3p hsa-miR-1255a hsa-miR-1256 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEU3 3' UTR sequence
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    Additional mRNA sequence: 

    AB008185.2 AK022450.1 AK290442.1 AK303540.1 BC136397.1 BC144059.1 Y18563.1 

    4 DOTS entries:

    DT.303574  DT.75122121  DT.100676762  DT.75143764 

    24 AceView cDNA sequences:

    BX108543 AI393335 AK022450 BP352846 BX094397 AI685339 AL597208 AB008185 
    NM_006656 AU122572 AI683302 Y18563 AA905424 CD652662 CD365337 BP354435 
    AW499956 AW608682 AU148123 AA578048 AW608659 BQ333413 AA621198 BQ333404 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NEU3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:              -     -           -           -                           
    SP2:                                -                                       
    SP3:                                -           -                           
    SP4:                                                                        
    SP5:                                -     -     -                           


    ECgene alternative splicing isoforms for NEU3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEU3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATCACTA
    NEU3 Expression
    About this image


    See NEU3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEU3

    SOURCE GeneReport for Unigene cluster: Hs.191074

    UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
    Tissue specificity: Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas,
    liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung

        SABiosciences Expression via Pathway-Focused PCR Array including NEU3: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NEU3 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neu31 , 5 neuraminidase 31, 5 77.7(n)1
    69.08(a)1
      7 (54.15 cM)5
    508771  NM_016720.21  NP_057929.11 
     998114395 
    chicken
    (Gallus gallus)
    Aves NEU31 sialidase 3 (membrane sialidase) 57.99(n)
    55.12(a)
      430542  XM_428099.3  XP_428099.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    50(a)
    49(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343489.1(373106-387283)
    GL343489.1(406567-408820)
    zebrafish
    (Danio rerio)
    Actinopterygii neu3.11 sialidase 3.1 54.99(n)
    55.35(a)
      780844  NM_001079665.1  NP_001073133.1 


    ENSEMBL Gene Tree for NEU3 (if available)
    TreeFam Gene Tree for NEU3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEU3 gene
    NEU22  NEU42  
    3 SIMAP similar genes for NEU3 using alignment to 7 protein entries:     NEUR3_HUMAN (see all proteins):
    L3MBTL2    NEU4    NEU2

    NEU3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/429 SNPs in NEU3 are shown (see all 429)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490966661,2
    --74698163(+) ATCATC/TCATTT 1 -- us2k10--------
    rs1884378201,2
    --74698320(+) CATATA/GTCGAT 1 -- us2k10--------
    rs1916787641,2
    --74698446(+) TTTATA/GGCTTT 1 -- us2k10--------
    rs1840788881,2
    --74698542(+) GGTTCC/TTTTGG 1 -- us2k10--------
    rs1888037461,2
    --74698549(+) TTGGGA/GACAAA 1 -- us2k10--------
    rs1808399121,2
    --74698569(+) TAAGAC/TCCATT 1 -- us2k10--------
    rs1448685001,2
    C--74698624(+) TAGGCC/TGAGGC 1 -- us2k10--------
    rs49449651,2
    C,F,A--74698676(+) ACATGG/ATGAAA 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs563414531,2
    --74698773(+) GAATGA/GCGTGA 1 -- us2k10--------
    rs1427385691,2
    --74698887(+) AGACCC/GATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEU3 (74699179 - 74729938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NEU3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832210CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604617    OMIM disorders: --

    18 diseases for NEU3:    About MalaCards
    galactosialidosis    mucolipidosis    hiv type 1    clear cell adenocarcinoma
    colon cancer    acute lymphoblastic leukemia    pneumonia    lymphoblastic leukemia
    influenza    renal cell carcinoma    neuroblastoma    adenocarcinoma
    melanoma    leukemia    endotheliitis    hepatitis
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NEU3:
    Mucolipidosis

    NEU3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NEU3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 39.8 5 16241905 (2), 19215228 (2), 12149448 (1)
    cancer 16.6 6 17334392 (2), 16241905 (1), 16428383 (1)

    Genetic Association Database (GAD): NEU3
    Human Genome Epidemiology (HuGE) Navigator: NEU3 (2 documents)

    Export disorders for NEU3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEU3 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with NEU3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. (PubMed id 10405317)1, 2, 3, 9 Wada T.... Miyagi T. (1999)
    2. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. (PubMed id 10861246)1, 2, 9 Monti E.... Borsani G. (2000)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. (PubMed id 16241905)1, 9 Kato K....Miyagi T. (2006)
    5. Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells. (PubMed id 18339327)1, 9 Jin U.H....Kim C.H. (2008)
    6. Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. (PubMed id 16428383)1, 9 Ueno S....Miyagi T. (2006)
    7. Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles. (PubMed id 16765317)1, 9 Yamaguchi K....Miyagi T. (2006)
    8. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. (PubMed id 17334392)1, 9 Wada T....Miyagi T. (2007)
    9. Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli. (PubMed id 15179041)1, 9 Ha K.T....Kim C.H. (2004)
    10. Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis. (PubMed id 17827720)1, 9 Azuma Y....Matsumoto K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10825 HGNC: 7760 AceView: NEU3 Ensembl:ENSG00000162139 euGenes: HUgn10825
    ECgene: NEU3 Kegg: 10825 H-InvDB: NEU3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEU3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEU3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEU3 gene:
    Search GeneIP for patents involving NEU3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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