Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NEU3 Gene

protein-coding   GIFtS: 59
GCID: GC11P074699

Sialidase 3 (Membrane Sialidase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sialidase 3 (Membrane Sialidase)1 2     EC 3.2.1.183 8
Ganglioside Sialidase2 3     SIAL32 5
Membrane Sialidase2 3     Neuraminidase 32
N-Acetyl-Alpha-Neuraminidase 32 3     sialidase-32

External Ids:    HGNC: 77601   Entrez Gene: 108252   Ensembl: ENSG000001621397   OMIM: 6046175   UniProtKB: Q9UQ493   

Export aliases for NEU3 gene to outside databases

Previous GC identifers: GC11P077026 GC11P076238 GC11P074921 GC11P074425 GC11P074376 GC11P070997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NEU3 Gene:
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from
glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for
gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. (provided by RefSeq,
Jul 2008)

GeneCards Summary for NEU3 Gene:
NEU3 (sialidase 3 (membrane sialidase)) is a protein-coding gene. Diseases associated with NEU3 include galactosialidosis, and mucolipidosis. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU2.

UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
Function: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound
sialyl glycoconjugates

Gene Wiki entry for NEU3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEU3 gene promoter:
         HOXA9B   HOXA9   AML1a   RREB-1   Pax-2   MyoD   Pax-2a   Ik-2   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEU3 promoter sequence
   Search Chromatin IP Primers for NEU3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEU3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5

NEU3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEU3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P074699:  view genomic region     (about GC identifiers)

Start:
74,699,179 bp from pter      End:
74,729,938 bp from pter
Size:
30,760 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49 (See protein sequence)
Recommended Name: Sialidase-3  
Size: 428 amino acids; 48252 Da
Sequence caution: Sequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9NQE1

Explore the universe of human proteins at neXtProt for NEU3: NX_Q9UQ49

Explore proteomics data for NEU3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys74, Lys154, Lys301, Lys426
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NEU3 (Q9UQ49)
     TFAVGPGH  GCQGSVVS 


    See NEU3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006647.3  
    ENSEMBL proteins: 
     ENSP00000294064   ENSP00000432097   ENSP00000434474   ENSP00000436540   ENSP00000434907  
     ENSP00000436118   ENSP00000434754   ENSP00000445591   ENSP00000439908  
    Reactome Protein details: Q9UQ49

    NEU3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NEU3
    OriGene Protein Over-expression Lysate for NEU3
    OriGene MassSpec for NEU3
    OriGene Custom Protein Services for NEU3
    GenScript Custom Purified and Recombinant Proteins Services for NEU3
    Novus Biologicals NEU3 Protein
    Novus Biologicals NEU3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NEU3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NEU3
    OriGene Custom Antibody Services for NEU3
    Novus Biologicals NEU3 Antibody
    Search for Antibodies for NEU3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for NEU3
    LSBio Antibodies in human, mouse, rat for NEU3

    NEU3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEU3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEU3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR011040 Sialidases
     IPR026856 Sialidase_fam
     IPR026944 Sialidase-3

    Graphical View of Domain Structure for InterPro Entry Q9UQ49

    ProtoNet protein and cluster: Q9UQ49

    UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
    Similarity: Belongs to the glycosyl hydrolase 33 family
    Similarity: Contains 3 BNR repeats


    NEU3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUR3_HUMAN, Q9UQ49
    Function: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound
    sialyl glycoconjugates
    Catalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal
    sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
    Biophysicochemical properties: pH dependence: Optimum pH is 3.8;

         Genatlas biochemistry entry for NEU3:
    neuraminidase 3,membrane sialidase

         Enzyme Number (IUBMB): EC 3.2.1.181 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004308exo-alpha-sialidase activity IDA10861246
    GO:0016997alpha-sialidase activity IDA12730204
    GO:0052794exo-alpha-(2->3)-sialidase activity ISS--
    GO:0052795exo-alpha-(2->6)-sialidase activity IEA--
    GO:0052796exo-alpha-(2->8)-sialidase activity ISS--
         
    NEU3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Neu3):
     homeostasis/metabolism  normal  tumorigenesis 

    NEU3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neu3tm1Yamk for NEU3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEU3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEU3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEU3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEU3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEU3:
    hsa-mir-1229-3p (MIRT036294), hsa-let-7a-5p (MIRT052460)

    Block miRNA regulation of human, mouse, rat NEU3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NEU3:
    hsa-miR-1283 hsa-miR-125a-3p hsa-miR-3688-3p hsa-miR-1255a hsa-miR-1256 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEU3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEU3
    Predesigned siRNA for gene silencing in human, mouse, rat NEU3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEU3

    Clone
    Products:
         
    OriGene clones in human, mouse for NEU3 (see all 6)
    OriGene ORF clones in mouse, rat for NEU3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEU3 (NM_006656)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEU3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NEU3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NEU3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NEUR3_HUMAN, Q9UQ49: Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    lysosome2
    nucleus2
    vacuole2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10405317

    NEU3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NEU3 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Other glycan degradation
    Other glycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for NEU3
        Sialic acid metabolism
    Glycosphingolipid metabolism


    2 Kegg Pathways  (Kegg details for NEU3):
        Other glycan degradation
    Sphingolipid metabolism


    NEU3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NEU3: 
              Glycosylation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NEU3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NEU3 (Q9UQ493 ENSP000002940644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTRK1P046293I2D: score=1 
    ARSAENSP000002161244STRING: ENSP00000216124
    GAL3ST1ENSP000003432344STRING: ENSP00000343234
    GALCENSP000002613044STRING: ENSP00000261304
    GLAENSP000002185164STRING: ENSP00000218516
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IDA12730204
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006689ganglioside catabolic process IDA10861246
    GO:0009313oligosaccharide catabolic process IDA10861246

    NEU3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEU3 (NEUR3)

    Selected HMDB Compounds for NEU3 (see all 99)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ganglioside GM1 (d18:0/12:0) --12486725
    Ganglioside GM1 (d18:0/14:0) --12486725
    Ganglioside GM1 (d18:0/16:0) --12486725
    Ganglioside GM1 (d18:0/18:0) --12486725
    Ganglioside GM1 (d18:0/18:1(11Z)) --12486725
    Ganglioside GM1 (d18:0/18:1(9Z)) --12486725
    Ganglioside GM1 (d18:0/20:0) --12486725
    Ganglioside GM1 (d18:0/22:0) --12486725
    Ganglioside GM1 (d18:0/22:1(13Z)) --12486725
    Ganglioside GM1 (d18:0/23:0) --12486725

    4 Novoseek inferred chemical compound relationships for NEU3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ganglioside 83.3 16 15179041 (3), 10405317 (2), 1879535 (1), 12164932 (1) (see all 11)
    lactosylceramide 73.5 2 16428383 (1), 19215228 (1)
    glycolipid 52.6 1 16428383 (1)
    tyrosine 11.7 7 16241905 (1), 17334392 (1)



    NEU3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NEU3 gene: 
    NM_006656.5  

    Unigene Cluster for NEU3:

    Sialidase 3 (membrane sialidase)
    Hs.191074  [show with all ESTs]
    Unigene Representative Sequence: Y18563
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294064(uc001ovv.3 uc001ovw.3 uc010rrl.2) ENST00000531509
    ENST00000529024 ENST00000526068 ENST00000532963 ENST00000531619 ENST00000534628
    ENST00000544263 ENST00000545272
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEU3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NEU3:
    hsa-miR-1283 hsa-miR-125a-3p hsa-miR-3688-3p hsa-miR-1255a hsa-miR-1256 hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEU3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEU3
    Predesigned siRNA for gene silencing in human, mouse, rat NEU3
    Clone
    Products:
         
    OriGene clones in human, mouse for NEU3 (see all 6)
    OriGene ORF clones in mouse, rat for NEU3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEU3 (NM_006656)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEU3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEU3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEU3
      QuantiTect SYBR Green Assays in human, mouse, rat NEU3
      QuantiFast Probe-based Assays in human, mouse, rat NEU3

    Additional mRNA sequence: 

    AB008185.2 AK022450.1 AK290442.1 AK303540.1 BC136397.1 BC144059.1 Y18563.1 

    4 DOTS entries:

    DT.303574  DT.75122121  DT.100676762  DT.75143764 

    24 AceView cDNA sequences:

    AK022450 BX108543 AI393335 AA905424 BX094397 AI685339 CD365337 AL597208 
    AU122572 AB008185 AI683302 NM_006656 CD652662 BP352846 Y18563 AW499956 
    BP354435 AU148123 AW608659 AA578048 AW608682 BQ333404 AA621198 BQ333413 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NEU3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:              -     -           -           -                           
    SP2:                                -                                       
    SP3:                                -           -                           
    SP4:                                                                        
    SP5:                                -     -     -                           


    ECgene alternative splicing isoforms for NEU3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NEU3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATCACTA
    NEU3 Expression
    About this image

    NEU3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEU3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191074

    UniProtKB/Swiss-Prot: NEUR3_HUMAN, Q9UQ49
    Tissue specificity: Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas,
    liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including NEU3: 
              Glycosylation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NEU3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEU3
    QuantiTect SYBR Green Assays in human, mouse, rat NEU3
    QuantiFast Probe-based Assays in human, mouse, rat NEU3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NEU3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neu31 , 5 neuraminidase 31, 5 77.62(n)1
    68.59(a)1
      7 (54.15 cM)5
    508771  NM_016720.21  NP_057929.11 
     998114395 
    chicken
    (Gallus gallus)
    Aves NEU31 sialidase 3 (membrane sialidase) 58.17(n)
    55.4(a)
      430542  XM_428099.4  XP_428099.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    55(a)
    54(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL343489.1(373106-387283)
    GL343489.1(406567-408820)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004967151 sialidase-3-like 58.83(n)
    52.22(a)
      100496715  XM_002942414.2  XP_002942460.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neu3.11 sialidase 3, tandem duplicate 1 54.99(n)
    55.35(a)
      780844  NM_001079665.1  NP_001073133.1 


    ENSEMBL Gene Tree for NEU3 (if available)
    TreeFam Gene Tree for NEU3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NEU3 gene
    NEU22  NEU42  
    3 SIMAP similar genes for NEU3 using alignment to 7 protein entries:     NEUR3_HUMAN (see all proteins):
    L3MBTL2    NEU4    NEU2

    NEU3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NEU3 (see all 429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490966661,2
    --74698163(+) ATCATC/TCATTT 1 -- us2k10--------
    rs1884378201,2
    --74698320(+) CATATA/GTCGAT 1 -- us2k10--------
    rs1916787641,2
    --74698446(+) TTTATA/GGCTTT 1 -- us2k10--------
    rs1840788881,2
    --74698542(+) GGTTCC/TTTTGG 1 -- us2k10--------
    rs1888037461,2
    --74698549(+) TTGGGA/GACAAA 1 -- us2k10--------
    rs1808399121,2
    --74698569(+) TAAGAC/TCCATT 1 -- us2k10--------
    rs1448685001,2
    C--74698624(+) TAGGCC/TGAGGC 1 -- us2k10--------
    rs49449651,2
    C,F,A--74698676(+) ACATGG/ATGAAA 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs563414531,2
    --74698773(+) GAATGA/GCGTGA 1 -- us2k10--------
    rs1427385691,2
    --74698887(+) AGACCC/GATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEU3 (74699179 - 74729938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NEU3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832210CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEU3
    DNA2.0 Custom Variant and Variant Library Synthesis for NEU3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604617    OMIM disorders: --

    15 diseases for NEU3:    
    About MalaCards
    galactosialidosis    mucolipidosis    clear cell adenocarcinoma    pneumonia
    influenza    lymphoblastic leukemia    neuroblastoma    renal cell carcinoma
    adenocarcinoma    endotheliitis    melanoma    prostate cancer
    leukemia    prostatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for NEU3:
    Mucolipidosis

    NEU3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NEU3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 39.8 5 16241905 (2), 19215228 (2), 12149448 (1)
    cancer 16.6 6 17334392 (2), 16241905 (1), 16428383 (1)

    Genetic Association Database (GAD): NEU3
    Human Genome Epidemiology (HuGE) Navigator: NEU3 (2 documents)

    Export disorders for NEU3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NEU3 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with NEU3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. (PubMed id 10405317)1, 2, 3, 9 Wada T.... Miyagi T. (Biochem. Biophys. Res. Commun. 1999)
    2. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. (PubMed id 10861246)1, 2, 9 Monti E.... Borsani G. (Biochem. J. 2000)
    3. Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis. (PubMed id 20511247)1, 2 Albohy A....Cairo C.W. (Glycobiology 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. (PubMed id 16241905)1, 9 Kato K....Miyagi T. (Biochem. J. 2006)
    6. Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells. (PubMed id 18339327)1, 9 Jin U.H....Kim C.H. (Biochim. Biophys. Acta 2008)
    7. Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. (PubMed id 16428383)1, 9 Ueno S....Miyagi T. (J. Biol. Chem. 2006)
    8. Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles. (PubMed id 16765317)1, 9 Yamaguchi K....Miyagi T. (Biochem. Biophys. Res. Commun. 2006)
    9. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. (PubMed id 17334392)1, 9 Wada T....Miyagi T. (Oncogene 2007)
    10. Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli. (PubMed id 15179041)1, 9 Ha K.T....Kim C.H. (Mol. Cells 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10825 HGNC: 7760 AceView: NEU3 Ensembl:ENSG00000162139 euGenes: HUgn10825
    ECgene: NEU3 Kegg: 10825 H-InvDB: NEU3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NEU3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEU3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NEU3 gene:
    Search GeneIP for patents involving NEU3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NEU3   OriGene RNAi products in human, mouse, rat for NEU3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NEU3  
     OriGene MassSpec something-or-other for NEU3   OriGene clones in human, mouse for NEU3  
     OriGene qSTAR qPCR primer pairs in human, mouse for NEU3   OriGene Purified Protein for NEU3  
     OriGene ORF clones in mouse, rat for NEU3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEU3   OriGene Custom Protein Services for NEU3  

     
     
     Block miRNA regulation of human, mouse, rat NEU3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NEU3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEU3 Predesigned siRNA for gene silencing in human, mouse, rat NEU3
     QuantiFast Probe-based Assays in human, mouse, rat NEU3 QuantiTect SYBR Green Assays in human, mouse, rat NEU3
     PCR Arrays including human, mouse, rat NEU3 Search Chromatin IP Primers for NEU3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEU3  GeneGlobe Interaction Network for NEU3
     Regulatory tfbs in NEU3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NEU3 GenScript cDNA clones with any tag delivered in your preferred vector for NEU3
     GenScript Custom Assay Services for NEU3 GenScript Custom overexpressing Cell Line Services for NEU3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NEU3 (NEUR3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NEU3 antibodies
     NEU3 proteins
     NEU3 lysates
     Search for Antibodies for NEU3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NEU3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NEU3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU3
     SwitchGear 3'UTR luciferase reporter plasmids for NEU3
     SwitchGear Promoter luciferase reporter plasmids for NEU3
     Search ThermoFisher Antibodies for NEU3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEU3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEU3
     LSBio Antibodies in human, mouse, rat for NEU3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NEU3 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4