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Aliases for NEU2 Gene

Aliases for NEU2 Gene

  • Sialidase 2 (Cytosolic Sialidase) 2 3
  • N-Acetyl-Alpha-Neuraminidase 2 2 3 4
  • Cytosolic Sialidase 3 4
  • EC 4 63
  • SIAL2 3 6
  • Neuraminidase 2 3
  • Sialidase-2 3

External Ids for NEU2 Gene

Previous GeneCards Identifiers for NEU2 Gene

  • GC02P231954
  • GC02P232626
  • GC02P233861
  • GC02P234099
  • GC02P233722
  • GC02P233605
  • GC02P233897
  • GC02P225744

Summaries for NEU2 Gene

Entrez Gene Summary for NEU2 Gene

  • This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]

GeneCards Summary for NEU2 Gene

NEU2 (Sialidase 2 (Cytosolic Sialidase)) is a Protein Coding gene. Diseases associated with NEU2 include galactosialidosis and stomach cancer. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU3.

UniProtKB/Swiss-Prot for NEU2 Gene

  • Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.

Gene Wiki entry for NEU2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEU2 Gene

Genomics for NEU2 Gene

Genomic Location for NEU2 Gene

233,032,672 bp from pter
233,035,057 bp from pter
2,386 bases
Plus strand

Genomic View for NEU2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEU2 Gene

Proteins for NEU2 Gene

  • Protein details for NEU2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3KNW4
    • Q6NTB4

    Protein attributes for NEU2 Gene

    380 amino acids
    Molecular mass:
    42254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NEU2 Gene

neXtProt entry for NEU2 Gene

Proteomics data for NEU2 Gene at MOPED

Selected DME Specific Peptides for NEU2 Gene

Post-translational modifications for NEU2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEU2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NEU2 Gene

Protein Domains for NEU2 Gene

Suggested Antigen Peptide Sequences for NEU2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 33 family.
  • Contains 2 BNR repeats.
  • Belongs to the glycosyl hydrolase 33 family.
  • Contains 2 BNR repeats.
genes like me logo Genes that share domains with NEU2: view

No data available for Gene Families for NEU2 Gene

Function for NEU2 Gene

Molecular function for NEU2 Gene

GENATLAS Biochemistry:
neuraminidase,glycohydrolytic enzyme,cytosolic,expressed in adult muscle
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
UniProtKB/Swiss-Prot Function:
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.

Enzyme Numbers (IUBMB) for NEU2 Gene

Gene Ontology (GO) - Molecular Function for NEU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0052794 exo-alpha-(2->3)-sialidase activity IDA 22228546
GO:0052795 exo-alpha-(2->6)-sialidase activity IEA --
GO:0052796 exo-alpha-(2->8)-sialidase activity IEA --
genes like me logo Genes that share ontologies with NEU2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEU2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEU2 Gene

Localization for NEU2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEU2 Gene


Subcellular locations from

Jensen Localization Image for NEU2 Gene COMPARTMENTS Subcellular localization image for NEU2 gene
Compartment Confidence
cytosol 4
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8253770
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEU2: view

Pathways for NEU2 Gene

genes like me logo Genes that share pathways with NEU2: view

Pathways by source for NEU2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NEU2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006689 ganglioside catabolic process IDA 22228546
GO:0009313 oligosaccharide catabolic process IDA 22228546
genes like me logo Genes that share ontologies with NEU2: view

Drugs for NEU2 Gene

(4) Drugbank Compounds for NEU2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2R,3R,4S)-3-(acetylamino)-4-Carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
139110-80-8 60855 Target inhibitor approved, investigational
  • (-)-Oseltamivir
204255-11-8 65028 Target inhibitor approved
2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid
13728878 Target experimental
46937111 Target experimental

(5) Novoseek inferred chemical compound relationships for NEU2 Gene

Compound -log(P) Hits PubMed IDs
2-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid 90.9 1
zanamivir 79.8 4
oseltamivir 78.6 4
sialic acid 64 1
ganglioside 54.1 1
genes like me logo Genes that share compounds with NEU2: view

Transcripts for NEU2 Gene

mRNA/cDNA for NEU2 Gene

(2) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEU2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEU2 Gene

No ASD Table

Relevant External Links for NEU2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEU2 Gene

mRNA expression in normal human tissues for NEU2 Gene

mRNA differential expression in normal tissues according to GTEx for NEU2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (35.4) and Skin - Sun Exposed (Lower leg) (14.8).

Protein differential expression in normal tissues for NEU2 Gene

This gene is overexpressed in Hair follicle (58.1) and Liver, secretome (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEU2 Gene

SOURCE GeneReport for Unigene cluster for NEU2 Gene Hs.532681

mRNA Expression by UniProt/SwissProt for NEU2 Gene

Tissue specificity: Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.
genes like me logo Genes that share expressions with NEU2: view

Expression partners for NEU2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NEU2 Gene

Orthologs for NEU2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEU2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NEU2 35
  • 79.6 (n)
  • 72.56 (a)
NEU2 36
  • 73 (a)
(Canis familiaris)
Mammalia NEU2 35
  • 81.52 (n)
  • 76.92 (a)
NEU2 36
  • 76 (a)
(Mus musculus)
Mammalia Neu2 35
  • 74.91 (n)
  • 69.15 (a)
Neu2 16
Neu2 36
  • 66 (a)
(Pan troglodytes)
Mammalia NEU2 35
  • 97.72 (n)
  • 96.83 (a)
NEU2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Neu2 35
  • 74.33 (n)
  • 68.18 (a)
(Monodelphis domestica)
Mammalia NEU2 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia NEU2 36
  • 59 (a)
(Gallus gallus)
Aves NEU2 35
  • 63.11 (n)
  • 57.33 (a)
NEU2 36
  • 56 (a)
(Danio rerio)
Actinopterygii neu3.1 36
  • 35 (a)
Species with no ortholog for NEU2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEU2 Gene

Gene Tree for NEU2 (if available)
Gene Tree for NEU2 (if available)

Paralogs for NEU2 Gene

Paralogs for NEU2 Gene

(2) SIMAP similar genes for NEU2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NEU2: view

Variants for NEU2 Gene

Sequence variations from dbSNP and Humsavar for NEU2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2233375 -- 233,031,788(+) GTGGA(C/T)CAATC upstream-variant-2KB
rs2233376 -- 233,031,947(+) AAATC(A/C)CTGTC upstream-variant-2KB
rs2233377 -- 233,032,045(+) AGCAC(C/T)CCACG upstream-variant-2KB
rs2233378 -- 233,032,253(+) AGTTA(G/T)AAAAA upstream-variant-2KB
rs2233379 -- 233,032,323(+) GCTGT(C/T)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEU2 Gene

Variant ID Type Subtype PubMed ID
nsv876009 CNV Gain 21882294
nsv876011 CNV Gain 21882294
nsv876012 CNV Gain 21882294

Relevant External Links for NEU2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEU2 Gene

Disorders for NEU2 Gene

(1) Novoseek inferred disease relationships for NEU2 Gene

Disease -log(P) Hits PubMed IDs
influenza 49.4 4

Relevant External Links for NEU2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NEU2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NEU2 Gene

Publications for NEU2 Gene

  1. Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules. (PMID: 14613940) Tringali C. … Monti E. (J. Biol. Chem. 2004) 2 3 4 23
  2. Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition. (PMID: 15501818) Chavas L.M.G. … Wakatsuki S. (J. Biol. Chem. 2005) 3 4 23
  3. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. (PMID: 17426694) Li C.-Y. … Wei L. (Cell Res. 2007) 3 4 23
  4. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. (PMID: 10191093) Monti E. … Borsani G. (Genomics 1999) 2 3 4
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48

Products for NEU2 Gene

Sources for NEU2 Gene

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