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NEU2 Gene

protein-coding   GIFtS: 55
GCID: GC02P233897

Sialidase 2 (Cytosolic Sialidase)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialidase 2 (Cytosolic Sialidase)1 2     SIAL22 5
N-Acetyl-Alpha-Neuraminidase 21 2 3     Neuraminidase 22
Cytosolic Sialidase2 3     sialidase-22
EC 3.2.1.183 8     

External Ids:    HGNC: 77591   Entrez Gene: 47592   Ensembl: ENSG000001154887   OMIM: 6055285   UniProtKB: Q9Y3R43   

Export aliases for NEU2 gene to outside databases

Previous GC identifers: GC02P231954 GC02P232626 GC02P233861 GC02P234099 GC02P233722 GC02P233605 GC02P225744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEU2 Gene:
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and
glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its
cytosolic localization was demonstrated by cell fractionation experiments. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEU2 Gene:
NEU2 (sialidase 2 (cytosolic sialidase)) is a protein-coding gene. Diseases associated with NEU2 include stomach cancer, and galactosialidosis. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU4.

UniProtKB/Swiss-Prot: NEUR2_HUMAN, Q9Y3R4
Function: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins,
oligosaccharides and gangliosides

Gene Wiki entry for NEU2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEU2 gene promoter:
         HOXA9   Brachyury   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   RORalpha2   C/EBPalpha   FOXJ2 (long isoform)   FOXJ2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEU2 promoter sequence
   Search Chromatin IP Primers for NEU2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEU2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37

NEU2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEU2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P233897:  view genomic region     (about GC identifiers)

Start:
233,897,382 bp from pter      End:
233,899,767 bp from pter
Size:
2,386 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NEUR2_HUMAN, Q9Y3R4 (See protein sequence)
Recommended Name: Sialidase-2  
Size: 380 amino acids; 42254 Da
Selected PDB 3D structures from and Proteopedia for NEU2 (see all 16):
1SNT (3D)        1SO7 (3D)        1VCU (3D)        2F0Z (3D)        2F10 (3D)        2F11 (3D)    
Secondary accessions: Q3KNW4 Q6NTB4

Explore the universe of human proteins at neXtProt for NEU2: NX_Q9Y3R4

Explore proteomics data for NEU2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NEU2 (Q9Y3R4)
     CAYSDLQ  HRSMNPCP  TFAVGPGH 


    See NEU2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005374.2  
    ENSEMBL proteins: 
     ENSP00000233840  
    Reactome Protein details: Q9Y3R4

    NEU2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NEU2
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    GenScript Custom Purified and Recombinant Proteins Services for NEU2
    Novus Biologicals NEU2 Protein
    Novus Biologicals NEU2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NEU2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEU2
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for NEU2
    Novus Biologicals NEU2 Antibodies
    Abcam antibodies for NEU2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for NEU2
    LSBio Antibodies in human, mouse, rat for NEU2

    NEU2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEU2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEU2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026945 Sialidase-2
     IPR011040 Sialidases
     IPR026856 Sialidase_fam

    Graphical View of Domain Structure for InterPro Entry Q9Y3R4

    ProtoNet protein and cluster: Q9Y3R4

    UniProtKB/Swiss-Prot: NEUR2_HUMAN, Q9Y3R4
    Similarity: Belongs to the glycosyl hydrolase 33 family
    Similarity: Contains 2 BNR repeats


    NEU2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUR2_HUMAN, Q9Y3R4
    Function: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins,
    oligosaccharides and gangliosides
    Catalytic activity: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal
    sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates

         Genatlas biochemistry entry for NEU2:
    neuraminidase,glycohydrolytic enzyme,cytosolic,expressed in adult muscle

         Enzyme Number (IUBMB): EC 3.2.1.181 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0052794exo-alpha-(2->3)-sialidase activity IDA--
    GO:0052795exo-alpha-(2->6)-sialidase activity IEA--
    GO:0052796exo-alpha-(2->8)-sialidase activity IEA--
         
    NEU2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEU2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEU2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEU2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEU2

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NEU2
    Predesigned siRNA for gene silencing in human, mouse, rat NEU2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEU2

    Clone
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    OriGene clones in human, mouse for NEU2 (see all 8)
    OriGene ORF clones in mouse, rat for NEU2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEU2 (NM_005383)
    Sino Biological Human cDNA Clone for NEU2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEU2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEU2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEU2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEUR2_HUMAN, Q9Y3R4: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    lysosome2
    nucleus2
    plasma membrane2
    vacuole2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8253770
    GO:0005829cytosol TAS--

    NEU2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEU2 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    Sphingolipid metabolism0.61
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Other glycan degradation
    Other glycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for NEU2
        Sialic acid metabolism
    Glycosphingolipid metabolism


    2 Kegg Pathways  (Kegg details for NEU2):
        Other glycan degradation
    Sphingolipid metabolism


    NEU2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NEU2: 
              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NEU2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NEU2 (ENSP000002338404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    GAL3ST1ENSP000003432344STRING: ENSP00000343234
    GALCENSP000002613044STRING: ENSP00000261304
    GLAENSP000002185164STRING: ENSP00000218516
    UGT8ENSP000003116484STRING: ENSP00000311648
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006689ganglioside catabolic process IDA--
    GO:0009313oligosaccharide catabolic process IDA--
    GO:0044281small molecule metabolic process TAS--

    NEU2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEU2 (NEUR2)

    Selected HMDB Compounds for NEU2 (see all 58)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Galactosylceramide (d18:1/16:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/18:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/18:1(9Z))Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/20:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/22:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/24:1(15Z))Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/26:1(17Z))Galactocerebroside (see all 15)----
    Ganglioside GA2 (d18:1/12:0)Asialo GM2 (see all 9)88506-68-7--
    Ganglioside GA2 (d18:1/16:0)Asialo GM2 (see all 9)88506-68-7--
    Ganglioside GA2 (d18:1/18:0)Asialo GM2 (see all 9)88506-68-7--

    4 DrugBank Compounds for NEU2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC ACID-- --target--10592235
    Oseltamivir-- 204255-11-8targetinhibitor20222714
    ZanamivirGANA (see all 5)139110-80-8targetinhibitor20222714
    2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid-- --target----

    5 Novoseek inferred chemical compound relationships for NEU2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2'-(4-methylumbelliferyl)-alpha-d-n-acetylneuraminic acid 90.9 1 10561456 (1)
    zanamivir 79.8 4 20452227 (1), 18694948 (1), 10641217 (1), 12685876 (1)
    oseltamivir 78.6 4 17426694 (2), 10641217 (1), 12685876 (1)
    sialic acid 64 1 17374613 (1)
    ganglioside 54.1 2 16869890 (1)



    NEU2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEU2 gene: 
    NM_005383.2  

    Unigene Cluster for NEU2:

    Sialidase 2 (cytosolic sialidase)
    Hs.532681
    Unigene Representative Sequence: NM_005383
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000233840(uc010zmn.2)

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NEU2
    Predesigned siRNA for gene silencing in human, mouse, rat NEU2
    Clone
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    OriGene clones in human, mouse for NEU2 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: NEU2 (NM_005383)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEU2
      QuantiTect SYBR Green Assays in human, mouse, rat NEU2
      QuantiFast Probe-based Assays in human, mouse, rat NEU2

    Additional mRNA sequence: 

    BC069151.1 BC107053.2 

    1 DOTS entry:

    DT.91733986 

    2 AceView cDNA sequences:

    BC069151 NM_005383 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEU2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACCCTGA
    NEU2 Expression
    About this image

    NEU2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEU2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532681

    UniProtKB/Swiss-Prot: NEUR2_HUMAN, Q9Y3R4
    Tissue specificity: Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1

        Pathway & Disease-focused RT2 Profiler PCR Array including NEU2: 
              Glycosylation in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NEU2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEU2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NEU2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neu21 , 5 neuraminidase 21, 5 74.91(n)1
    69.15(a)1
      1 (44.44 cM)5
    239561  NM_001160165.11  NP_001153637.11 
     875098895 
    chicken
    (Gallus gallus)
    Aves NEU21 sialidase 2 (cytosolic sialidase) 63.11(n)
    57.33(a)
      768823  XM_004936926.1  XP_004936983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neu3.16
    sialidase 3, tandem duplicate 1
    35(a)
    many ↔ many
    21(20743214-20746642) ENSDARG00000096382


    ENSEMBL Gene Tree for NEU2 (if available)
    TreeFam Gene Tree for NEU2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEU2 gene
    NEU42  NEU32  
    2 SIMAP similar genes for NEU2 using alignment to 1 protein entry:     NEUR2_HUMAN:
    NEU3    NEU4

    NEU2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEU2 (see all 168)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37545781,2
    C,F--233895476(-) tttttA/Ggtaga 1 -- us2k10--------
    rs1853748661,2
    --233895520(+) GTAATC/TGGGAG 1 -- us2k10--------
    rs1476329341,2
    --233895544(+) AAGCAC/TTTGAA 1 -- us2k10--------
    rs37545771,2
    C--233895587(-) GCAATA/GGCGAG 1 -- us2k10--------
    rs344913521,2
    C--233895605(+) CTGGGG/-CAACA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs124746261,2
    H--233895636(+) aaaaaA/Ggaaaa 1 -- us2k1 trp30--------
    rs124666551,2
    H--233895637(+) aaaaaA/Gaaaaa 1 -- us2k1 trp30--------
    rs1133581911,2
    C,F--233895638(+) AAAAGG/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1459111621,2
    --233895659(+) TTCCTC/TAGCTA 1 -- us2k10--------
    rs45117111,2
    C,F,A,H--233895666(+) GCTAAC/ACTTCT 1 -- us2k128Minor allele frequency- A:0.19NS EA NA WA CSA 2772

    HapMap Linkage Disequilibrium report for NEU2 (233897382 - 233899767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NEU2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876012CNV Gain21882294
    nsv876009CNV Gain21882294
    nsv876011CNV Gain21882294

    Human Gene Mutation Database (HGMD): NEU2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEU2
    DNA2.0 Custom Variant and Variant Library Synthesis for NEU2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605528    OMIM disorders: --

    10 diseases for NEU2:    
    About MalaCards
    stomach cancer    galactosialidosis    lysinuric protein intolerance    influenza
    lymphoblastic leukemia    rhabdomyosarcoma    sarcoma    leukemia
    prostate cancer    prostatitis


    NEU2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for NEU2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    influenza 49.4 4 20452227 (1), 10641217 (1), 15501818 (1), 12685876 (1)

    Genetic Association Database (GAD): NEU2
    Human Genome Epidemiology (HuGE) Navigator: NEU2 (1 document)

    Export disorders for NEU2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEU2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with NEU2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules. (PubMed id 14613940)1, 2, 3, 9 Tringali C....Monti E. (J. Biol. Chem. 2004)
    2. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. (PubMed id 10191093)1, 2, 3 Monti E.... Borsani G. (Genomics 1999)
    3. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. (PubMed id 17426694)1, 2, 9 Li C.-Y.... Wei L. (Cell Res. 2007)
    4. Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition. (PubMed id 15501818)1, 2, 9 Chavas L.M.G.... Wakatsuki S. (J. Biol. Chem. 2005)
    5. Molecular insight into substrate recognition by human cytosolic sialidase NEU2. (PubMed id 22228546)1, 2 Mozzi A....Monti E. (Proteins 2012)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Expression of a novel human sialidase encoded by the NEU2 gene. (PubMed id 10561456)1, 9 Monti E....Borsani G. (Glycobiology 1999)
    9. Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. (PubMed id 15213228)1, 9 Seyrantepe V....Pshezhetsky A.V. (J. Biol. Chem. 2004)
    10. Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus. (PubMed id 23908028)1 Gao F. and Bao J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4759 HGNC: 7759 AceView: NEU2 Ensembl:ENSG00000115488 euGenes: HUgn4759
    ECgene: NEU2 Kegg: 4759 H-InvDB: NEU2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEU2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEU2 gene:
    Search GeneIP for patents involving NEU2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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