Aliases for NEU2 Gene
External Ids for NEU2 Gene
Previous GeneCards Identifiers for NEU2 Gene
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]
GeneCards Summary for NEU2 Gene
NEU2 (Neuraminidase 2) is a Protein Coding gene. Diseases associated with NEU2 include Discrete Subaortic Stenosis and Subvalvular Aortic Stenosis. Among its related pathways are Sphingolipid metabolism and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. An important paralog of this gene is NEU4.
UniProtKB/Swiss-Prot for NEU2 Gene
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.