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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NETO2 Gene

protein-coding GIFtS: 50
GCID: GC16M047056

neuropilin (NRP) and tolloid (TLL)-like 2

Explore 6 diseases affiliated with
NETO2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuropilin (NRP) And Tolloid (TLL)-Like 2¹ ²
NEOT2¹ ² ⁵
Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 2² ³
BTCL2² ³
FLJ10430¹
Neuropilin And Tolloid-Like Protein 2²

External Ids:	HGNC: 14644¹	Entrez Gene: 81831²	Ensembl: ENSG00000171208⁷	OMIM: 607974⁵	UniProtKB: Q8NC67³

Export aliases for NETO2 gene to outside databases

Previous GC identifers: GC16M037526 GC16M046855 GC16M046896 GC16M045672 GC16M033005

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NETO2:

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density

lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the

brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile

hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript

variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67

Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases

kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at

the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of

kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus

directly influencing synaptic transmission (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NETO2 gene promoter:
SRF TBP SRF (504 AA) CUTL1 Nkx2-5 Gfi-1 CREB FAC1 Cart-1 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NETO2 promoter sequence

Search SABiosciences Chromatin IP Primers for NETO2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NETO2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q11.2

NETO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NETO2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M047056: view genomic region (about GC identifiers)

Start:	47,111,614 bp from pter	End:	47,177,908 bp from pter
Size:	66,295 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67 (See protein sequence)

Recommended Name: Neuropilin and tolloid-like protein 2 precursor

Size: 525 amino acids; 59393 Da

Subunit: Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors (By

similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: Q7Z381 Q8ND51 Q96SP4 Q9NVY8

Alternative splicing: 2 isoforms: Q8NC67-1 Q8NC67-2

Explore the universe of human proteins at neXtProt for NETO2: NX_Q8NC67

Post-translational modifications:

N-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NC67

NETO2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001188406.1 NP_060562.3

ENSEMBL proteins:

ENSP00000455169 ENSP00000306726 ENSP00000454213 ENSP00000457133 ENSP00000456818

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NETO2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

NETO2 for ontologies About GeneDecksing

NETO2 Antibody Products:

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	Uscn ELISAs and CLIAs for NETO2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NETO2 for domains About GeneDecksing

3 InterPro domains/families:

IPR000859 CUB_dom

IPR002172 LDrepeatLR_classA_rpt

IPR023415 LDLR_class-A_CS

Graphical View of Domain Structure for InterPro Entry Q8NC67

ProtoNet protein and cluster: Q8NC67

2 Blocks protein families:

IPB000859 CUB domain

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67

Similarity: Contains 2 CUB domains

Similarity: Contains 1 LDL-receptor class A domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67

Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases

kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at

the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of

kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus

directly influencing synaptic transmission (By similarity)

miRNA Products:		miRTarBase miRNAs that target NETO2: hsa-mir-1 (MIRT002815)

		OriGene 3'-UTR Clone: NETO2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NETO2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NETO2:
		hsa-miR-144 hsa-miR-561
		SwitchGear 3'UTR luciferase reporter plasmid: NETO2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NETO2 (see all 7) OriGene shRNA RFP: NETO2 OriGene siRNA: NETO2
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NETO2
		Search LifeMap BioReagents cell lines for NETO2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--

NETO2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NETO2:

Decreased homologous recombina

Animal Models:
Mouse knock-out Neto2^tm1Mci for NETO2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Neto2):

nervous system

NETO2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NETO2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NETO2 (ENSP00000306726⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NETO2
Search CenterWatch for drugs/clinical trials and news about NETO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NETO2 gene (2 alternative transcripts):

NM_001201477.1 NM_018092.4

Unigene Cluster for NETO2:

Neuropilin (NRP) and tolloid (TLL)-like 2

Hs.645802 [show with all ESTs]

Unigene Representative Sequence: NM_018092

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562435(uc002eeq.2 uc002eer.2 uc010vgf.2) ENST00000303155

ENST00000562559 ENST00000564667 ENST00000563078

miRNA Products:		OriGene 3'-UTR Clone: NETO2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NETO2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NETO2:
		hsa-miR-144 hsa-miR-561
		SwitchGear 3'UTR luciferase reporter plasmid: NETO2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NETO2 (see all 7) OriGene shRNA RFP: NETO2 OriGene siRNA: NETO2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NETO2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NETO2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NETO2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NETO2 (NM_018092)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NETO2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NETO2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NETO2

Additional cDNA sequence:

AK001292.1 AK027478.1 AK027630.1 AK074937.1 AK297408.1 AL834404.1 AY358718.1 BC012381.1

BC065504.1 BC098380.1 BC108727.1 BX538063.1 CR457255.1

11 DOTS entries:

DT.216288 DT.120729212 DT.100682910 DT.100814444 DT.100814448 DT.100672019 DT.120729255 DT.120729317

DT.100814449 DT.120729471 DT.75120202

24/134 AceView cDNA sequences (see all 134):

BU541123 T16809 AK074937 AL834404 W60661 AU126249 AA374468 AK001292

BC065504 NM_018092 CB215853 AA127201 AA923566 Z40835 BM468070 AY358718

CA310847 BM455232 BC012381 BF507730 AA456821 W32128 AK027478 BM720029

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NETO2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b
SP1:
SP2:													-
SP3:																			-

ECgene alternative splicing isoforms for NETO2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NETO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NETO2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NETO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NETO2

SOURCE GeneReport for Unigene cluster: Hs.645802

SABiosciences Custom PCR Arrays for NETO2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NETO2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NETO2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NETO2 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NETO2¹	neuropilin (NRP) and tolloid (TLL)-like 2	83.76(n) 91.32(a)		415743 XM_414109.3 XP_414109.3
lizard (Anolis carolinensis)	Reptilia	NETO2⁶	--	90(a)	1 ↔ 1	LGc(3362918-3388198)
zebrafish (Danio rerio)	Actinopterygii	LOC556331¹	neuropilin and tolloid-like protein 2-like	70.56(n) 78.12(a)		556331 XM_679100.5 XP_684192.5
fruit fly (Drosophila melanogaster)	Insecta	Neto⁶	Neuropilin and tolloid-like	18(a)	1 → many	X(13339939-13413663)
worm (Caenorhabditis elegans)	Secernentea	neto-1¹	Protein NETO-1	47.22(n) 33.67(a)		186950 NM_058758.2 NP_491159.2

ENSEMBL Gene Tree for NETO2 (if available)
TreeFam Gene Tree for NETO2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NETO2 gene

TLL2² CUBN² CDCP2² PCOLCE² BMP1² PCOLCE2² MFRP² NETO1²

TLL1²

4 SIMAP similar genes for NETO2 using alignment to 6 protein entries: NETO2_HUMAN (see all proteins):

NETO1 NRP1 NRP2 CUBN

NETO2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NETO2
PGOHUM00000240044 PGOHUM00000249792

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192871802^1,2		--	47115067(+)	`ATTAAA/TTATAG`	2	--	ds500¹		0	--	--	--	--
rs185384403^1,2		--	47115311(+)	`ACGTTA/GTATTT`	2	--	ds500¹		0	--	--	--	--
rs187860107^1,2		--	47115358(+)	`AATCAC/TGAATA`	2	--	ds500¹		0	--	--	--	--
rs142710041^1,2		--	47115650(+)	`CTTTCC/TATACA`	2	--	ut3¹		0	--	--	--	--
rs192939388^1,2		--	47115661(+)	`TACCTG/TAAGAT`	2	--	ut3¹		0	--	--	--	--
rs16952122^1,2	C,F,H,	--	47115776(+)	`AAAATT/CTATCA`	2	--	ut3¹		9		NA NS EA WA	658
rs151000137^1,2		--	47115820(+)	`GCTTAC/TGTCCA`	2	--	ut3¹		0	--	--	--	--
rs140832312^1,2		--	47115874(+)	`CACAGC/GATATT`	2	--	ut3¹		0	--	--	--	--
rs183481091^1,2		--	47115963(+)	`CAGTAC/TCAAAT`	2	--	ut3¹		0	--	--	--	--
rs72812490^1,2	C,	--	47116066(+)	`AAGTGA/GAAGTT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NETO2 (47111614 - 47177908 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NETO2
1 Indel: 72580

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NETO2

DNA2.0 Custom Variant and Variant Library Synthesis for NETO2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NETO2 for disorders           About GeneDecksing

OMIM gene information: 607974    OMIM disorders: --

6 diseases for NETO2:    About MalaCards

hemangioma spastic cerebral palsy cerebral palsy spasticity

cerebritis neuronitis

Export disorders for NETO2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NETO2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with NETO2)

Utopia: connect your pdf to the dynamic
world of online information

A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PubMed id 11943477)^{1, 3, 9} Stoehr H.... Weber B.H.F. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling. (PubMed id 19349369)¹ Calicchio M.L....Kozakewich H.P. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
A transmembrane accessory subunit that modulates kain ate-type glutamate receptors. (PubMed id 19217376)¹ Zhang W....Tomita S. (2009)
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF. (PubMed id 18841201)¹ Sanford J.R....Caceres J.F. (2008)
Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. (PubMed id 17671192)¹ Horak C.E....Steeg P.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 81831	HGNC: 14644	AceView: NETO2	Ensembl:ENSG00000171208	euGenes: HUgn81831
ECgene: NETO2	H-InvDB: NETO2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NETO2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NETO2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NETO2 gene:
Search GeneIP for patents involving NETO2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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NETO2 Gene

neuropilin (NRP) and tolloid (TLL)-like 2

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NETO2 Gene

neuropilin (NRP) and tolloid (TLL)-like 2

Aliasesfor NETO2 gene

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Protein Domains /Familiesfor NETO2 gene

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Specialized Databases showing NETO2 gene

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for NETO2 gene

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for NETO2 gene

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for NETO2 gene

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for NETO2 gene

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for NETO2 gene

Pathways & Interactions
for NETO2 gene

Drugs & Compounds
for NETO2 gene

Transcripts
for NETO2 gene

Expression
for NETO2 gene

Orthologs
for NETO2 gene

Paralogs
for NETO2 gene

Genomic Variants
for NETO2 gene

Disorders / Diseases
for NETO2 gene

Publications
for NETO2 gene

Intellectual Property
for NETO2 gene

Products
for NETO2 gene