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NETO2 Gene

protein-coding   GIFtS: 50
GCID: GC16M047056

Neuropilin (NRP) And Tolloid (TLL)-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropilin (NRP) And Tolloid (TLL)-Like 21 2
Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor
Class A Domains Protein 22 3
BTCL22 3
NEOT22 5
Neuropilin And Tolloid-Like Protein 22

External Ids:    HGNC: 146441   Entrez Gene: 818312   Ensembl: ENSG000001712087   OMIM: 6079745   UniProtKB: Q8NC673   

Export aliases for NETO2 gene to outside databases

Previous GC identifers: GC16M037526 GC16M046855 GC16M046896 GC16M045672 GC16M033005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NETO2 Gene:
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a
low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate
signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for
proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, Jan 2011)

GeneCards Summary for NETO2 Gene:
NETO2 (neuropilin (NRP) and tolloid (TLL)-like 2) is a protein-coding gene. Diseases associated with NETO2 include spastic cerebral palsy, and hemangioma. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67
Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases
kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their
expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the
agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic
currents (EPSCs), thus directly influencing synaptic transmission (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NETO2 gene promoter:
         SRF   TBP   SRF (504 AA)   CUTL1   Nkx2-5   Gfi-1   CREB   FAC1   Cart-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNETO2 promoter sequence
   Search Chromatin IP Primers for NETO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NETO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q11.2

NETO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NETO2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M047056:  view genomic region     (about GC identifiers)

Start:
47,111,614 bp from pter      End:
47,177,936 bp from pter
Size:
66,323 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67 (See protein sequence)
Recommended Name: Neuropilin and tolloid-like protein 2 precursor  
Size: 525 amino acids; 59393 Da
Subunit: Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors (By
similarity)
Secondary accessions: J3KNF1 Q7Z381 Q8ND51 Q96SP4 Q9NVY8
Alternative splicing: 3 isoforms:  Q8NC67-1   Q8NC67-2   Q8NC67-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for NETO2: NX_Q8NC67

Explore proteomics data for NETO2 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Ubiquitination2 at Lys386
  • Glycosylation2 at Asn311
  • Modification sites at PhosphoSitePlus

  • See NETO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188406.1  NP_060562.3  

    ENSEMBL proteins: 
     ENSP00000455169   ENSP00000306726   ENSP00000454213   ENSP00000457133   ENSP00000456818  

    NETO2 Human Recombinant Protein Products:

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    Novus Biologicals NETO2 Proteins
    Novus Biologicals NETO2 Lysates
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    Cloud-Clone Corp. CLIAs for NETO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR023415 LDLR_class-A_CS
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR028868 NETO2

    Graphical View of Domain Structure for InterPro Entry Q8NC67

    ProtoNet protein and cluster: Q8NC67

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: NETO2_HUMAN, Q8NC67
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 LDL-receptor class A domain


    NETO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NETO2_HUMAN, Q8NC67
    Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases
    kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their
    expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the
    agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic
    currents (EPSCs), thus directly influencing synaptic transmission (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    NETO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NETO2:
     Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Neto2):
     nervous system 

    NETO2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Neto2tm1Mci for NETO2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NETO2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NETO2

    miRNA
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    miRTarBase miRNAs that target NETO2:
    hsa-mir-20a-5p (MIRT050610), hsa-mir-375 (MIRT020025), hsa-mir-21-5p (MIRT031045), hsa-mir-1 (MIRT002815), hsa-mir-24-3p (MIRT030591)

    Block miRNA regulation of human, mouse, rat NETO2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NETO2:
    hsa-miR-144 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidNETO2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NETO2 (NM_018092)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NETO2_HUMAN, Q8NC67: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    plasma membrane2
    chloroplast1
    extracellular1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane ----
    GO:0032983kainate selective glutamate receptor complex IEA--

    NETO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NETO2
    Interactions:

        Search GeneGlobe Interaction Network for NETO2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NETO2 (ENSP000003067264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:2000312regulation of kainate selective glutamate receptor activity IEA--

    NETO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NETO2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NETO2 gene (2 alternative transcripts): 
    NM_001201477.1  NM_018092.4  

    Unigene Cluster for NETO2:

    Neuropilin (NRP) and tolloid (TLL)-like 2
    Hs.645802  [show with all ESTs]
    Unigene Representative Sequence: NM_018092
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562435(uc002eeq.2 uc002eer.2 uc010vgf.2) ENST00000303155
    ENST00000562559 ENST00000564667 ENST00000563078
    miRNA
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    Block miRNA regulation of human, mouse, rat NETO2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NETO2:
    hsa-miR-144 hsa-miR-561
    SwitchGear 3'UTR luciferase reporter plasmidNETO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NETO2
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    GenScript: all cDNA clones in your preferred vector (see all 2): NETO2 (NM_018092)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NETO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NETO2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NETO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NETO2
      QuantiTect SYBR Green Assays in human, mouse, rat NETO2
      QuantiFast Probe-based Assays in human, mouse, rat NETO2

    Additional mRNA sequence: 

    AK001292.1 AK027478.1 AK027630.1 AK074937.1 AK297408.1 AL834404.1 AY358718.1 BC012381.1 
    BC065504.1 BC098380.1 BC108727.1 BX538063.1 CR457255.1 

    11 DOTS entries:

    DT.216288  DT.120729212  DT.100682910  DT.100814444  DT.100814448  DT.100672019  DT.120729255  DT.120729317 
    DT.100814449  DT.120729471  DT.75120202 

    Selected AceView cDNA sequences (see all 134):

    CA310847 BM720029 AA456821 Z40835 BU541123 AA127201 BM468070 BC065504 
    AI143581 AY358718 BM455232 BF507730 BU543447 Z41415 AL834404 W60661 
    AK001292 AA374468 CB215853 NM_018092 AU126249 T16809 AK074937 BM771297 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NETO2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                        
    SP2:                                      -                                 
    SP3:                                                        -               


    ECgene alternative splicing isoforms for NETO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NETO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NETO2 Expression
    About this image


    NETO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
    NETO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NETO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645802
        Custom PCR Arrays for NETO2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NETO2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neto21 , 5 neuropilin (NRP) and tolloid (TLL)-like 21, 5 91.65(n)1
    97.83(a)1
      8 (41.61 cM)5
    745131  NM_001081324.11  NP_001074793.11 
     856365885 
    chicken
    (Gallus gallus)
    Aves NETO21 neuropilin (NRP) and tolloid (TLL)-like 2 83.75(n)
    91.05(a)
      415743  XM_004944188.1  XP_004944245.1 
    lizard
    (Anolis carolinensis)
    Reptilia NETO26
    neuropilin (NRP) and tolloid (TLL)-like 2
    90(a)
    1 ↔ 1
    LGc(3338906-3388211)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia neto21 neuropilin (NRP) and tolloid (TLL)-like 2 79.37(n)
    89.33(a)
      780374  NM_001079444.1  NP_001072912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5563311 neuropilin and tolloid-like protein 2-like 69.02(n)
    74.76(a)
      556331  XM_679100.6  XP_684192.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Neto6
    Neuropilin and tolloid-like
    20(a)
    1 → many
    X(13339939-13413663)
    worm
    (Caenorhabditis elegans)
    Secernentea neto-11 neto-1 47.42(n)
    33.63(a)
      186950  NM_058758.3  NP_491159.3 


    ENSEMBL Gene Tree for NETO2 (if available)
    TreeFam Gene Tree for NETO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NETO2 gene
    TLL22  CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  MFRP2  NETO12  
    TLL12  
    3 SIMAP similar genes for NETO2 using alignment to 5 protein entries:     NETO2_HUMAN (see all proteins):
    NETO1    NRP2    CUBN

    NETO2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NETO2
    PGOHUM00000240044 PGOHUM00000249792


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NETO2 (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928718021,2
    --47115067(+) ATTAAA/TTATAG 2 -- ds50010--------
    rs1853844031,2
    --47115311(+) ACGTTA/GTATTT 2 -- ds50010--------
    rs1878601071,2
    --47115358(+) AATCAC/TGAATA 2 -- ds50010--------
    rs1427100411,2
    --47115650(+) CTTTCC/TATACA 2 -- ut310--------
    rs1929393881,2
    --47115661(+) TACCTG/TAAGAT 2 -- ut310--------
    rs169521221,2
    C,F,H--47115776(+) AAAATT/CTATCA 2 -- ut319Minor allele frequency- C:0.03NA NS EA WA 658
    rs1510001371,2
    --47115820(+) GCTTAC/TGTCCA 2 -- ut310--------
    rs1408323121,2
    --47115874(+) CACAGC/GATATT 2 -- ut310--------
    rs1834810911,2
    --47115963(+) CAGTAC/TCAAAT 2 -- ut310--------
    rs728124901,2
    C--47116066(+) AAGTGA/GAAGTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NETO2 (47111614 - 47177936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NETO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659121CNV Deletion23128226
    nsv528423CNV Loss19592680
    esv22069CNV Loss19812545
    nsv906660CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607974    OMIM disorders: --

    8 diseases for NETO2:    
    About MalaCards
    spastic cerebral palsy    hemangioma    cerebral palsy    spasticity
    cerebritis    bronchiolitis    hepatitis    neuronitis


    NETO2 for disorders           About GeneDecksing


    Export disorders for NETO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NETO2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NETO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PubMed id 11943477)1, 3, 9 Stoehr H.... Weber B.H.F. (Gene 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling. (PubMed id 19349369)1 Calicchio M.L....Kozakewich H.P. (Am. J. Pathol. 2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. A transmembrane accessory subunit that modulates kainate-type glutamate receptors. (PubMed id 19217376)1 Zhang W....Tomita S. (Neuron 2009)
    9. Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF. (PubMed id 18841201)1 Sanford J.R....Caceres J.F. (PLoS ONE 2008)
    10. Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. (PubMed id 17671192)1 Horak C.E....Steeg P.S. (Cancer Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81831 HGNC: 14644 AceView: NETO2 Ensembl:ENSG00000171208 euGenes: HUgn81831
    ECgene: NETO2 H-InvDB: NETO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NETO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NETO2 gene:
    Search GeneIP for patents involving NETO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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