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Aliases for NETO2 Gene

Aliases for NETO2 Gene

  • Neuropilin (NRP) And Tolloid (TLL)-Like 2 2 3
  • Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 2 3 4
  • NEOT2 3 6
  • BTCL2 3 4
  • Neuropilin And Tolloid-Like Protein 2 3

External Ids for NETO2 Gene

Summaries for NETO2 Gene

Entrez Gene Summary for NETO2 Gene

  • This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NETO2 Gene

NETO2 (Neuropilin (NRP) And Tolloid (TLL)-Like 2) is a Protein Coding gene. An important paralog of this gene is TLL1.

UniProtKB/Swiss-Prot for NETO2 Gene

  • Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NETO2 Gene

Genomics for NETO2 Gene

Genomic Location for NETO2 Gene

Start:
47,077,703 bp from pter
End:
47,144,025 bp from pter
Size:
66,323 bases
Orientation:
Minus strand

Genomic View for NETO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NETO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NETO2 Gene

Regulatory Elements for NETO2 Gene

Proteins for NETO2 Gene

  • Protein details for NETO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC67-NETO2_HUMAN
    Recommended name:
    Neuropilin and tolloid-like protein 2
    Protein Accession:
    Q8NC67
    Secondary Accessions:
    • J3KNF1
    • Q7Z381
    • Q8ND51
    • Q96SP4
    • Q9NVY8

    Protein attributes for NETO2 Gene

    Size:
    525 amino acids
    Molecular mass:
    59393 Da
    Quaternary structure:
    • Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.

    Alternative splice isoforms for NETO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NETO2 Gene

Proteomics data for NETO2 Gene at MOPED

Post-translational modifications for NETO2 Gene

Other Protein References for NETO2 Gene

No data available for DME Specific Peptides for NETO2 Gene

Domains for NETO2 Gene

UniProtKB/Swiss-Prot:

NETO2_HUMAN
Domain:
  • Contains 2 CUB domains.:
    • Q8NC67
  • Contains 1 LDL-receptor class A domain.:
    • Q8NC67
genes like me logo Genes that share domains with NETO2: view

No data available for Gene Families for NETO2 Gene

Function for NETO2 Gene

Molecular function for NETO2 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

Gene Ontology (GO) - Molecular Function for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0035255 ionotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with NETO2: view

Phenotypes for NETO2 Gene

MGI mutant phenotypes for NETO2:
inferred from 1 alleles
GenomeRNAi human phenotypes for NETO2:
genes like me logo Genes that share phenotypes with NETO2: view

Animal Models for NETO2 Gene

MGI Knock Outs for NETO2:

miRNA for NETO2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NETO2 Gene

Localization for NETO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NETO2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NETO2 Gene COMPARTMENTS Subcellular localization image for NETO2 gene
Compartment Confidence
endoplasmic reticulum 2
plasma membrane 2
chloroplast 1
extracellular 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0032983 kainate selective glutamate receptor complex IEA --
GO:0045202 synapse --
genes like me logo Genes that share ontologies with NETO2: view

Pathways for NETO2 Gene

SuperPathways for NETO2 Gene

No Data Available

Interacting Proteins for NETO2 Gene

Gene Ontology (GO) - Biological Process for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000312 regulation of kainate selective glutamate receptor activity IEA --
genes like me logo Genes that share ontologies with NETO2: view

No data available for Pathways by source for NETO2 Gene

Transcripts for NETO2 Gene

Unigene Clusters for NETO2 Gene

Neuropilin (NRP) and tolloid (TLL)-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NETO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -

Relevant External Links for NETO2 Gene

GeneLoc Exon Structure for
NETO2
ECgene alternative splicing isoforms for
NETO2

Expression for NETO2 Gene

mRNA expression in normal human tissues for NETO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NETO2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.5), Brain - Putamen (basal ganglia) (4.6), and Brain - Caudate (basal ganglia) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NETO2 Gene

SOURCE GeneReport for Unigene cluster for NETO2 Gene Hs.645802

genes like me logo Genes that share expressions with NETO2: view

Orthologs for NETO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NETO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NETO2 36
  • 100 (n)
  • 100 (a)
NETO2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NETO2 36
  • 93.27 (n)
  • 97.14 (a)
NETO2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NETO2 36
  • 92.82 (n)
  • 98.24 (a)
NETO2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neto2 36
  • 91.65 (n)
  • 97.83 (a)
Neto2 16
Neto2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NETO2 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NETO2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neto2 36
  • 90.35 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves NETO2 36
  • 83.75 (n)
  • 91.05 (a)
NETO2 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NETO2 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neto2 36
  • 79.37 (n)
  • 89.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC556331 36
  • 69.02 (n)
  • 74.76 (a)
NETO2 (1 of 2) 37
  • 72 (a)
OneToMany
neto2b 37
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Neto 37
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea neto-1 36
  • 47.42 (n)
  • 33.63 (a)
neto-1 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3506 37
  • 25 (a)
ManyToMany
Species with no ortholog for NETO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NETO2 Gene

ENSEMBL:
Gene Tree for NETO2 (if available)
TreeFam:
Gene Tree for NETO2 (if available)

Paralogs for NETO2 Gene

Paralogs for NETO2 Gene

Selected SIMAP similar genes for NETO2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NETO2 Gene

genes like me logo Genes that share paralogs with NETO2: view

Variants for NETO2 Gene

Sequence variations from dbSNP and Humsavar for NETO2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1548916 -- 47,120,179(+) ATAGA(G/T)ACATT intron-variant
rs1894944 -- 47,096,904(+) GGGTG(C/G)AGGGT intron-variant
rs2078255 -- 47,116,964(-) tgaaa(C/G)agaga intron-variant
rs2078256 -- 47,116,945(-) ACTAC(A/C)GACCC intron-variant
rs2160479 -- 47,108,313(+) tgggt(A/T)agaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NETO2 Gene

Variant ID Type Subtype PubMed ID
esv2659121 CNV Deletion 23128226
nsv906660 CNV Loss 21882294
nsv528423 CNV Loss 19592680
esv22069 CNV Loss 19812545

Relevant External Links for NETO2 Gene

HapMap Linkage Disequilibrium report
NETO2

Disorders for NETO2 Gene

No disorders were found for NETO2 Gene.

No data available for UniProtKB/Swiss-Prot for NETO2 Gene

Publications for NETO2 Gene

  1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PMID: 11943477) Stoehr H. … Weber B.H.F. (Gene 2002) 2 3 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NETO2 Gene

Sources for NETO2 Gene

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