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Aliases for NETO2 Gene

Aliases for NETO2 Gene

  • Neuropilin And Tolloid Like 2 2 3 5
  • Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 2 3 4
  • Neuropilin (NRP) And Tolloid (TLL)-Like 2 2 3
  • BTCL2 3 4
  • Neuropilin And Tolloid-Like Protein 2 3
  • NEOT2 3

External Ids for NETO2 Gene

Previous GeneCards Identifiers for NETO2 Gene

  • GC16M037526
  • GC16M047056
  • GC16M046855
  • GC16M046896
  • GC16M045672
  • GC16M033005

Summaries for NETO2 Gene

Entrez Gene Summary for NETO2 Gene

  • This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NETO2 Gene

NETO2 (Neuropilin And Tolloid Like 2) is a Protein Coding gene. Diseases associated with NETO2 include Autosomal Recessive Non-Syndromic Intellectual Disability. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is NETO1.

UniProtKB/Swiss-Prot for NETO2 Gene

  • Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NETO2 Gene

Genomics for NETO2 Gene

Regulatory Elements for NETO2 Gene

Enhancers for NETO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NETO2 on UCSC Golden Path with GeneCards custom track

Promoters for NETO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NETO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NETO2 Gene

Chromosome:
16
Start:
47,077,703 bp from pter
End:
47,144,025 bp from pter
Size:
66,323 bases
Orientation:
Minus strand

Genomic View for NETO2 Gene

Genes around NETO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NETO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NETO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NETO2 Gene

Proteins for NETO2 Gene

  • Protein details for NETO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC67-NETO2_HUMAN
    Recommended name:
    Neuropilin and tolloid-like protein 2
    Protein Accession:
    Q8NC67
    Secondary Accessions:
    • J3KNF1
    • Q7Z381
    • Q8ND51
    • Q96SP4
    • Q9NVY8

    Protein attributes for NETO2 Gene

    Size:
    525 amino acids
    Molecular mass:
    59393 Da
    Quaternary structure:
    • Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.

    Alternative splice isoforms for NETO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NETO2 Gene

Post-translational modifications for NETO2 Gene

Other Protein References for NETO2 Gene

Antibody Products

  • Abcam antibodies for NETO2

No data available for DME Specific Peptides for NETO2 Gene

Domains & Families for NETO2 Gene

Suggested Antigen Peptide Sequences for NETO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NC67

UniProtKB/Swiss-Prot:

NETO2_HUMAN :
  • Contains 2 CUB domains.
Domain:
  • Contains 2 CUB domains.
  • Contains 1 LDL-receptor class A domain.
genes like me logo Genes that share domains with NETO2: view

No data available for Gene Families for NETO2 Gene

Function for NETO2 Gene

Molecular function for NETO2 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).

Gene Ontology (GO) - Molecular Function for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035255 ionotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with NETO2: view

Phenotypes for NETO2 Gene

genes like me logo Genes that share phenotypes with NETO2: view

Animal Models for NETO2 Gene

MGI Knock Outs for NETO2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NETO2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NETO2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NETO2 Gene

Localization for NETO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NETO2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NETO2 Gene COMPARTMENTS Subcellular localization image for NETO2 gene
Compartment Confidence
plasma membrane 3
chloroplast 2
endoplasmic reticulum 2
golgi apparatus 2
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016021 integral component of membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with NETO2: view

Pathways & Interactions for NETO2 Gene

SuperPathways for NETO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NETO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000312 regulation of kainate selective glutamate receptor activity IEA --
genes like me logo Genes that share ontologies with NETO2: view

No data available for Pathways by source and SIGNOR curated interactions for NETO2 Gene

Drugs & Compounds for NETO2 Gene

No Compound Related Data Available

Transcripts for NETO2 Gene

Unigene Clusters for NETO2 Gene

Neuropilin (NRP) and tolloid (TLL)-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NETO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NETO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: -

Relevant External Links for NETO2 Gene

GeneLoc Exon Structure for
NETO2
ECgene alternative splicing isoforms for
NETO2

Expression for NETO2 Gene

mRNA expression in normal human tissues for NETO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NETO2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Putamen (basal ganglia) (x4.6), and Brain - Caudate (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for NETO2 Gene

This gene is overexpressed in Fetal Brain (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NETO2 Gene



Protein tissue co-expression partners for NETO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NETO2 Gene:

NETO2

SOURCE GeneReport for Unigene cluster for NETO2 Gene:

Hs.645802
genes like me logo Genes that share expression patterns with NETO2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NETO2 Gene

Orthologs for NETO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NETO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NETO2 34
  • 93.27 (n)
  • 97.14 (a)
NETO2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NETO2 34
  • 92.82 (n)
  • 98.24 (a)
NETO2 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neto2 34
  • 91.65 (n)
  • 97.83 (a)
Neto2 16
Neto2 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NETO2 34
  • 100 (n)
  • 100 (a)
NETO2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neto2 34
  • 90.35 (n)
  • 97.14 (a)
oppossum
(Monodelphis domestica)
Mammalia NETO2 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NETO2 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves NETO2 34
  • 83.75 (n)
  • 91.05 (a)
NETO2 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NETO2 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neto2 34
  • 79.37 (n)
  • 89.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC556331 34
  • 69.02 (n)
  • 74.76 (a)
NETO2 (1 of 2) 35
  • 72 (a)
OneToMany
neto2b 35
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Neto 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea neto-1 34
  • 47.42 (n)
  • 33.63 (a)
neto-1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3506 35
  • 25 (a)
ManyToMany
Species where no ortholog for NETO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NETO2 Gene

ENSEMBL:
Gene Tree for NETO2 (if available)
TreeFam:
Gene Tree for NETO2 (if available)

Paralogs for NETO2 Gene

Paralogs for NETO2 Gene

(3) SIMAP similar genes for NETO2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NETO2 Gene

genes like me logo Genes that share paralogs with NETO2: view

Variants for NETO2 Gene

Sequence variations from dbSNP and Humsavar for NETO2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2231983 - 47,083,433(-) TCAGT(A/T)CCATG reference, missense
rs3095622 -- 47,137,422(-) CTCTC(A/G)CTGTT intron-variant
rs3095623 -- 47,127,149(-) TTTTC(A/G)TGCAA intron-variant
rs3095624 -- 47,125,064(-) AATAA(C/T)GTTTT intron-variant
rs3095625 -- 47,114,440(-) AAAAA(A/G)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NETO2 Gene

Variant ID Type Subtype PubMed ID
esv22069 CNV loss 19812545
esv2659121 CNV deletion 23128226
esv3332279 CNV insertion 20981092
esv3638547 CNV loss 21293372
esv3638549 CNV loss 21293372
nsv1066115 CNV gain 25217958
nsv1121912 CNV deletion 24896259
nsv1144768 CNV deletion 24896259
nsv528423 CNV loss 19592680

Variation tolerance for NETO2 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NETO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NETO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NETO2 Gene

Disorders for NETO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NETO2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search NETO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NETO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NETO2
genes like me logo Genes that share disorders with NETO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NETO2 Gene

Publications for NETO2 Gene

  1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PMID: 11943477) Stoehr H. … Weber B.H.F. (Gene 2002) 2 3 22 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 65

Products for NETO2 Gene

Sources for NETO2 Gene

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