Aliases for NETO1 Gene
External Ids for NETO1 Gene
Previous GeneCards Identifiers for NETO1 Gene
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for NETO1 Gene
NETO1 (Neuropilin And Tolloid Like 1) is a Protein Coding gene. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is NETO2.
UniProtKB/Swiss-Prot for NETO1 Gene
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).