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NETO1 Gene

protein-coding   GIFtS: 54
GCID: GC18M070413

Neuropilin (NRP) And Tolloid (TLL)-Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropilin (NRP) And Tolloid (TLL)-Like 11 2
Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor
Class A Domains Protein 12 3
BTCL12 3
BCTL12 5
Neuropilin And Tolloid-Like Protein 12

External Ids:    HGNC: 138231   Entrez Gene: 818322   Ensembl: ENSG000001663427   OMIM: 6079735   UniProtKB: Q8TDF53   

Export aliases for NETO1 gene to outside databases

Previous GC identifers: GC18M070103 GC18M070490 GC18M068558 GC18M068560 GC18M067134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NETO1 Gene:
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a
low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical
role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor
complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for NETO1 Gene:
NETO1 (neuropilin (NRP) and tolloid (TLL)-like 1) is a protein-coding gene. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal
N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the
postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in
the context of spatial learning and memory (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NETO1 gene promoter:
         CP2   AML1a   FOXJ2 (long isoform)   FOXJ2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNETO1 promoter sequence
   Search Chromatin IP Primers for NETO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NETO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.2

NETO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NETO1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M070413:  view genomic region     (about GC identifiers)

Start:
70,409,549 bp from pter      End:
70,535,381 bp from pter
Size:
125,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5 (See protein sequence)
Recommended Name: Neuropilin and tolloid-like protein 1 precursor  
Size: 533 amino acids; 60191 Da
Subunit: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A
and GRIN2B via its CUB domains (By similarity)
Secondary accessions: Q86W85 Q8ND78 Q8TDF4
Alternative splicing: 3 isoforms:  Q8TDF5-3   Q8TDF5-1   Q8TDF5-2   

Explore the universe of human proteins at neXtProt for NETO1: NX_Q8TDF5

Explore proteomics data for NETO1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn305, Asn339
  • Modification sites at PhosphoSitePlus

  • See NETO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188394.1  NP_620416.1  NP_620552.1  

    ENSEMBL proteins: 
     ENSP00000464312   ENSP00000462993   ENSP00000313088   ENSP00000464188   ENSP00000299430  
     ENSP00000381024  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR023415 LDLR_class-A_CS
     IPR028867 NETO1
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt

    Graphical View of Domain Structure for InterPro Entry Q8TDF5

    ProtoNet protein and cluster: Q8TDF5

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 LDL-receptor class A domain


    Find genes that share domains with NETO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NETO1_HUMAN, Q8TDF5
    Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal
    N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the
    postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in
    the context of spatial learning and memory (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NETO1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neto1):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with NETO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Neto1tm1(KOMP)Vlcg for NETO1

       genOway: Develop your customized and physiologically relevant rodent model for NETO1

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    hsa-miR-411* hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-92b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NETO1_HUMAN, Q8TDF5: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction,
    synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Component of the postsynaptic
    density (PSD) of excitatory synapses (By similarity)
    NETO1_HUMAN, Q8TDF5: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
    NETO1_HUMAN, Q8TDF5: Isoform 1: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    extracellular3
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0014069postsynaptic density ISS--
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--
    GO:0032983kainate selective glutamate receptor complex IEA--

    Find genes that share ontologies with NETO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NETO1
    Interactions:

        Search GeneGlobe Interaction Network for NETO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NETO1 (Q8TDF53 ENSP000003130884) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523I2D: score=1 
    GRIN1ENSP000003606164STRING: ENSP00000360616
    DLG2ENSP000003652724STRING: ENSP00000365272
    DLG3ENSP000003634804STRING: ENSP00000363480
    GRIN2AENSP000003325494STRING: ENSP00000332549
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007613memory ISS--
    GO:0008542visual learning ISS--
    GO:0048169regulation of long-term neuronal synaptic plasticity ISS--

    Find genes that share ontologies with NETO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for NETO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NETO1 gene (4 alternative transcripts): 
    NM_001201465.1  NM_138966.3  NM_138999.1  NM_153181.2  

    Unigene Cluster for NETO1:

    Neuropilin (NRP) and tolloid (TLL)-like 1
    Hs.465407  [show with all ESTs]
    Unigene Representative Sequence: NM_138966
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583169(uc002lkw.3) ENST00000582281 ENST00000327305(uc002lky.2)
    ENST00000579730 ENST00000580049 ENST00000579169 ENST00000577184 ENST00000299430
    ENST00000397929(uc002lkz.3)
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    hsa-miR-411* hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-92b
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    Additional mRNA sequence: 

    AF448838.1 AF448839.1 AK123319.1 AL834354.1 BC050329.1 

    6 DOTS entries:

    DT.423170  DT.40221077  DT.105821  DT.99943064  DT.99999031  DT.91650519 

    20 AceView cDNA sequences:

    AF448839 NM_138999 NM_138966 BM424062 BM811265 NM_153181 BG704590 BG497575 
    AF448838 BX090080 BC050329 AL834354 AW900095 CF147133 R85884 AA013001 
    BF698373 AA019587 AA013000 BM172209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NETO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTTTATA
    NETO1 Expression
    About this image


    NETO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    NETO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NETO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465407

    UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
    Tissue specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower
    levels in adult and fetal brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NETO1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neto11 , 5 neuropilin (NRP) and tolloid (TLL)-like 11, 5 90.49(n)1
    95.87(a)1
      18 (58.47 cM)5
    2463171  NM_144946.41  NP_659195.31 
     863949525 
    chicken
    (Gallus gallus)
    Aves NETO11 neuropilin (NRP) and tolloid (TLL)-like 1 86.87(n)
    92.87(a)
      421018  XM_419104.4  XP_419104.3 
    lizard
    (Anolis carolinensis)
    Reptilia NETO16
    neuropilin (NRP) and tolloid (TLL)-like 1
    92(a)
    1 ↔ 1
    4(48323857-48461751)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia neto11 neuropilin (NRP) and tolloid (TLL)-like 1 81.73(n)
    88.28(a)
      100492295  XM_002940474.2  XP_002940520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii neto1l1 neuropilin (NRP) and tolloid (TLL)-like 1, like 74.75(n)
    79.14(a)
      100331363  XM_005162662.1  XP_005162719.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Neto6
    Neuropilin and tolloid-like
    20(a)
    1 → many
    X(13339939-13413663)
    worm
    (Caenorhabditis elegans)
    Secernentea K03E5.13   -- 33(a)   I(3429559-3431835)   --


    ENSEMBL Gene Tree for NETO1 (if available)
    TreeFam Gene Tree for NETO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NETO1 gene
    TLL22  CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  NETO22  MFRP2  
    TLL12  
    3 SIMAP similar genes for NETO1 using alignment to 2 protein entries:     NETO1_HUMAN (see all proteins):
    NETO2    NRP1    NRP2

    Find genes that share paralogs with NETO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NETO1 (see all 2963)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360625891,2
    C--70283039(+) TTTTTT/-GAGGC 2 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1440507401,2
    C--70409131(+) AAGAG-/AGAA  
            
    AGAAA
    1 -- ds50010--------
    rs2007622691,2
    C--70409142(+) GAAAG-/AAAG  
            
    AAGAA
    1 -- ds50010--------
    rs729623371,2
    C--70409338(+) TATTAC/TGTGAA 1 -- ds50010--------
    rs1432069771,2
    C--70409414(+) TATACC/TTCATG 1 -- ds50010--------
    rs1844267811,2
    --70409420(+) TCATGA/CTGAGT 1 -- ds50010--------
    rs1512187731,2
    --70409543(+) ACACAC/GAGTCA 1 -- ds50010--------
    rs99505161,2
    C,F,A,H--70409589(+) AGTTCC/TGAGGG 1 -- ut31 ese315Minor allele frequency- T:0.35NS EA NA WA CSA 790
    rs116639331,2
    C,F,H--70409590(+) GTTCTG/CAGGGG 1 -- ut31 ese32Minor allele frequency- C:0.19WA NA 238
    rs1897706261,2
    --70409671(+) CATGAC/TTTAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NETO1 (70409549 - 70535381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NETO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458290CNV Loss19166990
    nsv526339CNV Loss19592680
    nsv526519CNV Loss19592680
    esv27222CNV Loss19812545
    nsv9644CNV Loss18304495
    nsv828305CNV Loss20364138
    esv34051CNV Loss18971310
    nsv2351CNV Loss18451855
    esv988415CNV Loss20482838
    dgv1051e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607973    OMIM disorders: --


    Find genes that share disorders with NETO1           About GenesLikeMe

    Genetic Association Database (GAD): NETO1
    Human Genome Epidemiology (HuGE) Navigator: NETO1 (3 documents)

    Export disorders for NETO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NETO1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NETO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PubMed id 11943477)1, 2, 3, 9 Stoehr H.... Weber B.H.F. (Gene 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PubMed id 23408906)1 Porcu E....Naitza S. (PLoS Genet. 2013)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. Neto1 associates with the NMDA receptor/amyloid precursor protein complex. (PubMed id 23621516)1 Cousins S.L....Stephenson F.A. (J. Neurochem. 2013)
    7. The genetic architecture of economic and political preferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. (PubMed id 22205981)1 Banno M....Ozaki N. (PLoS ONE 2011)
    9. Genetic determinants of autism in individuals with deletions of 18q. (PubMed id 20499253)1 O'Donnell L....Cody J.D. (Hum. Genet. 2010)
    10. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)4 Han M.R....Wang L.S. (BMC Neurol 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81832 HGNC: 13823 AceView: NETO1 Ensembl:ENSG00000166342 euGenes: HUgn81832
    ECgene: NETO1 H-InvDB: NETO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NETO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NETO1 gene:
    Search GeneIP for patents involving NETO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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