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Aliases for NETO1 Gene

Aliases for NETO1 Gene

  • Neuropilin (NRP) And Tolloid (TLL)-Like 1 2 3
  • Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 1 3 4
  • BCTL1 3 6
  • BTCL1 3 4
  • Neuropilin And Tolloid-Like Protein 1 3

External Ids for NETO1 Gene

Previous GeneCards Identifiers for NETO1 Gene

  • GC18M070103
  • GC18M070490
  • GC18M068558
  • GC18M068560
  • GC18M067134
  • GC18M070413

Summaries for NETO1 Gene

Entrez Gene Summary for NETO1 Gene

  • This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NETO1 Gene

NETO1 (Neuropilin (NRP) And Tolloid (TLL)-Like 1) is a Protein Coding gene. An important paralog of this gene is TLL1.

UniProtKB/Swiss-Prot for NETO1 Gene

  • Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NETO1 Gene

Genomics for NETO1 Gene

Regulatory Elements for NETO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NETO1 Gene

Start:
72,742,314 bp from pter
End:
72,868,146 bp from pter
Size:
125,833 bases
Orientation:
Minus strand

Genomic View for NETO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NETO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NETO1 Gene

Proteins for NETO1 Gene

  • Protein details for NETO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDF5-NETO1_HUMAN
    Recommended name:
    Neuropilin and tolloid-like protein 1
    Protein Accession:
    Q8TDF5
    Secondary Accessions:
    • Q86W85
    • Q8ND78
    • Q8TDF4

    Protein attributes for NETO1 Gene

    Size:
    533 amino acids
    Molecular mass:
    60191 Da
    Quaternary structure:
    • Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).

    Alternative splice isoforms for NETO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NETO1 Gene

Proteomics data for NETO1 Gene at MOPED

Post-translational modifications for NETO1 Gene

  • Glycosylation at Asn305 and Asn339
  • Modification sites at PhosphoSitePlus

Other Protein References for NETO1 Gene

No data available for DME Specific Peptides for NETO1 Gene

Domains for NETO1 Gene

Suggested Antigen Peptide Sequences for NETO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDF5

UniProtKB/Swiss-Prot:

NETO1_HUMAN :
  • Q8TDF5
Domain:
  • Contains 2 CUB domains.
  • Contains 1 LDL-receptor class A domain.
genes like me logo Genes that share domains with NETO1: view

No data available for Gene Families for NETO1 Gene

Function for NETO1 Gene

Molecular function for NETO1 Gene

UniProtKB/Swiss-Prot Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

Gene Ontology (GO) - Molecular Function for NETO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0035255 ionotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with NETO1: view

Phenotypes for NETO1 Gene

genes like me logo Genes that share phenotypes with NETO1: view

Animal Models for NETO1 Gene

MGI Knock Outs for NETO1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NETO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NETO1 Gene

Localization for NETO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NETO1 Gene

Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 1: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NETO1 Gene COMPARTMENTS Subcellular localization image for NETO1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
extracellular 3
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NETO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
GO:0032983 kainate selective glutamate receptor complex IEA --
GO:0045202 synapse --
genes like me logo Genes that share ontologies with NETO1: view

Pathways for NETO1 Gene

SuperPathways for NETO1 Gene

No Data Available

Interacting Proteins for NETO1 Gene

Gene Ontology (GO) - Biological Process for NETO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007613 memory ISS --
GO:0008542 visual learning ISS --
GO:0048168 regulation of neuronal synaptic plasticity --
GO:0048169 regulation of long-term neuronal synaptic plasticity ISS --
GO:0097120 receptor localization to synapse IEA --
genes like me logo Genes that share ontologies with NETO1: view

No data available for Pathways by source for NETO1 Gene

Transcripts for NETO1 Gene

Unigene Clusters for NETO1 Gene

Neuropilin (NRP) and tolloid (TLL)-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NETO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NETO1 Gene

No ASD Table

Relevant External Links for NETO1 Gene

GeneLoc Exon Structure for
NETO1
ECgene alternative splicing isoforms for
NETO1

Expression for NETO1 Gene

mRNA expression in normal human tissues for NETO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NETO1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.7), Brain - Frontal Cortex (BA9) (6.2), Brain - Putamen (basal ganglia) (5.6), Brain - Caudate (basal ganglia) (5.4), Brain - Cortex (5.4), Brain - Nucleus accumbens (basal ganglia) (5.2), and Brain - Hippocampus (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NETO1 Gene

SOURCE GeneReport for Unigene cluster for NETO1 Gene Hs.465407

mRNA Expression by UniProt/SwissProt for NETO1 Gene

Q8TDF5-NETO1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.
genes like me logo Genes that share expressions with NETO1: view

In Situ Assay Products

Orthologs for NETO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NETO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NETO1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NETO1 35
  • 91.49 (n)
  • 97 (a)
NETO1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NETO1 35
  • 93.12 (n)
  • 97.56 (a)
NETO1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neto1 35
  • 90.49 (n)
  • 95.87 (a)
Neto1 16
Neto1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NETO1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NETO1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neto1 35
  • 90.68 (n)
  • 95.68 (a)
chicken
(Gallus gallus)
Aves NETO1 35
  • 86.87 (n)
  • 92.87 (a)
NETO1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NETO1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neto1 35
  • 81.73 (n)
  • 88.28 (a)
zebrafish
(Danio rerio)
Actinopterygii neto1 36
  • 66 (a)
OneToMany
neto1l 35
  • 74.75 (n)
  • 79.14 (a)
neto1l 36
  • 78 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Neto 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea neto-1 36
  • 31 (a)
OneToMany
K03E5.1 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for NETO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NETO1 Gene

ENSEMBL:
Gene Tree for NETO1 (if available)
TreeFam:
Gene Tree for NETO1 (if available)

Paralogs for NETO1 Gene

Paralogs for NETO1 Gene

Selected SIMAP similar genes for NETO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NETO1: view

Variants for NETO1 Gene

Sequence variations from dbSNP and Humsavar for NETO1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs748016 -- 72,848,817(+) tctga(C/T)gccct intron-variant
rs753147 -- 72,793,824(-) GAGCC(A/G)TGGCT intron-variant
rs753744 -- 72,860,414(+) GTATG(C/T)GTGGT intron-variant
rs753745 -- 72,860,428(+) CAAAA(A/C)TGTAT intron-variant
rs753746 -- 72,860,473(+) GGAGA(C/T)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NETO1 Gene

Variant ID Type Subtype PubMed ID
esv34051 CNV Loss 18971310
nsv828305 CNV Loss 20364138
dgv1051e1 CNV Complex 17122850
nsv9644 CNV Loss 18304495
esv27222 CNV Loss 19812545
esv988415 CNV Loss 20482838
nsv2351 CNV Loss 18451855
nsv526339 CNV Loss 19592680
nsv526519 CNV Loss 19592680
nsv458290 CNV Loss 19166990

Relevant External Links for NETO1 Gene

HapMap Linkage Disequilibrium report
NETO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NETO1 Gene

Disorders for NETO1 Gene

Relevant External Links for NETO1

Genetic Association Database (GAD)
NETO1
Human Genome Epidemiology (HuGE) Navigator
NETO1
genes like me logo Genes that share disorders with NETO1: view

No data available for UniProtKB/Swiss-Prot for NETO1 Gene

Publications for NETO1 Gene

  1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PMID: 11943477) Stoehr H. … Weber B.H.F. (Gene 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population. (PMID: 22205981) Banno M. … Ozaki N. (PLoS ONE 2011) 3
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for NETO1 Gene

Sources for NETO1 Gene

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