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Aliases for NETO1 Gene

Aliases for NETO1 Gene

  • Neuropilin And Tolloid Like 1 2 3 5
  • Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 1 3 4
  • Neuropilin (NRP) And Tolloid (TLL)-Like 1 2 3
  • BTCL1 3 4
  • BCTL1 3

External Ids for NETO1 Gene

Previous GeneCards Identifiers for NETO1 Gene

  • GC18M070103
  • GC18M070490
  • GC18M068558
  • GC18M068560
  • GC18M067134
  • GC18M070413

Summaries for NETO1 Gene

Entrez Gene Summary for NETO1 Gene

  • This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NETO1 Gene

NETO1 (Neuropilin And Tolloid Like 1) is a Protein Coding gene. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is MFRP.

UniProtKB/Swiss-Prot for NETO1 Gene

  • Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NETO1 Gene

Genomics for NETO1 Gene

Regulatory Elements for NETO1 Gene

Enhancers for NETO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NETO1 on UCSC Golden Path with GeneCards custom track

Promoters for NETO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NETO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NETO1 Gene

Chromosome:
18
Start:
72,742,314 bp from pter
End:
72,868,146 bp from pter
Size:
125,833 bases
Orientation:
Minus strand

Genomic View for NETO1 Gene

Genes around NETO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NETO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NETO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NETO1 Gene

Proteins for NETO1 Gene

  • Protein details for NETO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDF5-NETO1_HUMAN
    Recommended name:
    Neuropilin and tolloid-like protein 1
    Protein Accession:
    Q8TDF5
    Secondary Accessions:
    • Q86W85
    • Q8ND78
    • Q8TDF4

    Protein attributes for NETO1 Gene

    Size:
    533 amino acids
    Molecular mass:
    60191 Da
    Quaternary structure:
    • Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity).

    Alternative splice isoforms for NETO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NETO1 Gene

Proteomics data for NETO1 Gene at MOPED

Post-translational modifications for NETO1 Gene

  • Glycosylation at Asn 305 and Asn 339
  • Modification sites at PhosphoSitePlus

Other Protein References for NETO1 Gene

Antibody Products

  • Abcam antibodies for NETO1

No data available for DME Specific Peptides for NETO1 Gene

Domains & Families for NETO1 Gene

Suggested Antigen Peptide Sequences for NETO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDF5

UniProtKB/Swiss-Prot:

NETO1_HUMAN :
  • Contains 2 CUB domains.
Domain:
  • Contains 2 CUB domains.
  • Contains 1 LDL-receptor class A domain.
genes like me logo Genes that share domains with NETO1: view

No data available for Gene Families for NETO1 Gene

Function for NETO1 Gene

Molecular function for NETO1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
genes like me logo Genes that share phenotypes with NETO1: view

Animal Models for NETO1 Gene

MGI Knock Outs for NETO1:

Animal Model Products

miRNA for NETO1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NETO1 Gene

Localization for NETO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NETO1 Gene

Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Component of the postsynaptic density (PSD) of excitatory synapses. {ECO:0000250}.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 1: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NETO1 Gene COMPARTMENTS Subcellular localization image for NETO1 gene
Compartment Confidence
extracellular 4
plasma membrane 4
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NETO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032983 kainate selective glutamate receptor complex IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with NETO1: view

Pathways & Interactions for NETO1 Gene

SuperPathways for NETO1 Gene

No Data Available

Interacting Proteins for NETO1 Gene

Gene Ontology (GO) - Biological Process for NETO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048168 regulation of neuronal synaptic plasticity IEA --
GO:0097120 receptor localization to synapse IEA --
genes like me logo Genes that share ontologies with NETO1: view

No data available for Pathways by source and SIGNOR curated interactions for NETO1 Gene

Drugs & Compounds for NETO1 Gene

No Compound Related Data Available

Transcripts for NETO1 Gene

Unigene Clusters for NETO1 Gene

Neuropilin (NRP) and tolloid (TLL)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NETO1 Gene

No ASD Table

Relevant External Links for NETO1 Gene

GeneLoc Exon Structure for
NETO1
ECgene alternative splicing isoforms for
NETO1

Expression for NETO1 Gene

mRNA expression in normal human tissues for NETO1 Gene

mRNA differential expression in normal tissues according to GTEx for NETO1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Frontal Cortex (BA9) (x6.2), Brain - Putamen (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x5.4), Brain - Cortex (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Brain - Hippocampus (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NETO1 Gene



SOURCE GeneReport for Unigene cluster for NETO1 Gene Hs.465407

mRNA Expression by UniProt/SwissProt for NETO1 Gene

Q8TDF5-NETO1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.
genes like me logo Genes that share expression patterns with NETO1: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NETO1 Gene

Orthologs for NETO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NETO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NETO1 35
  • 91.49 (n)
  • 97 (a)
NETO1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NETO1 35
  • 93.12 (n)
  • 97.56 (a)
NETO1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neto1 35
  • 90.49 (n)
  • 95.87 (a)
Neto1 16
Neto1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neto1 35
  • 90.68 (n)
  • 95.68 (a)
oppossum
(Monodelphis domestica)
Mammalia NETO1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NETO1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NETO1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves NETO1 35
  • 86.87 (n)
  • 92.87 (a)
NETO1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NETO1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neto1 35
  • 81.73 (n)
  • 88.28 (a)
zebrafish
(Danio rerio)
Actinopterygii neto1l 35
  • 74.75 (n)
  • 79.14 (a)
neto1 36
  • 66 (a)
OneToMany
neto1l 36
  • 78 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Neto 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K03E5.1 37
  • 33 (a)
neto-1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for NETO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NETO1 Gene

ENSEMBL:
Gene Tree for NETO1 (if available)
TreeFam:
Gene Tree for NETO1 (if available)

Paralogs for NETO1 Gene

Paralogs for NETO1 Gene

(3) SIMAP similar genes for NETO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NETO1: view

Variants for NETO1 Gene

Sequence variations from dbSNP and Humsavar for NETO1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs922999 - 72,750,161(+) AGTAG(C/T)TGTGT nc-transcript-variant, reference, missense
rs17086286 - 72,750,143(+) CATCT(C/G)CAGCA nc-transcript-variant, reference, missense
rs1564785 -- 72,788,402(-) GAAAG(C/T)GTGAT intron-variant
rs1601208 -- 72,802,818(+) AATTT(G/T)ACTTA intron-variant
rs7231566 -- 72,826,771(+) actca(C/G)gaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NETO1 Gene

Variant ID Type Subtype PubMed ID
esv34051 CNV Loss 18971310
nsv828305 CNV Loss 20364138
dgv1051e1 CNV Complex 17122850
nsv9644 CNV Loss 18304495
esv27222 CNV Loss 19812545
esv988415 CNV Loss 20482838
nsv2351 CNV Loss 18451855
nsv526339 CNV Loss 19592680
nsv526519 CNV Loss 19592680
nsv458290 CNV Loss 19166990

Variation tolerance for NETO1 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.47; 55.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NETO1 Gene

Disorders for NETO1 Gene

Relevant External Links for NETO1

Genetic Association Database (GAD)
NETO1
Human Genome Epidemiology (HuGE) Navigator
NETO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NETO1

No disorders were found for NETO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NETO1 Gene

Publications for NETO1 Gene

  1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PMID: 11943477) Stoehr H. … Weber B.H.F. (Gene 2002) 2 3 4 23 67
  2. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk R.J. … de Jongste J.C. (J. Allergy Clin. Immunol. 2014) 3
  3. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PMID: 23408906) Porcu E. … Naitza S. (PLoS Genet. 2013) 3
  4. Neto1 associates with the NMDA receptor/amyloid precursor protein complex. (PMID: 23621516) Cousins S.L. … Stephenson F.A. (J. Neurochem. 2013) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for NETO1 Gene

Sources for NETO1 Gene

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