Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NETO1 Gene

protein-coding   GIFtS: 51
GCID: GC18M070490

neuropilin (NRP) and tolloid (TLL)-like 1

 Explore 1 disease affiliated with
NETO1 via our new
 Human Malady Compendium 
Biological research products
for NETO1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neuropilin (NRP) And Tolloid (TLL)-Like 11 2
BTCL11 2 3
BCTL11 2 5
Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class
A Domains Protein 12 3
Neuropilin And Tolloid-Like Protein 12

External Ids:    HGNC: 138231   Entrez Gene: 818322   Ensembl: ENSG000001663427   OMIM: 6079735   UniProtKB: Q8TDF53   

Export aliases for NETO1 gene to outside databases

Previous GC identifers: GC18M070103 GC18M068558 GC18M068560 GC18M067134


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NETO1:
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density
lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial
learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the
hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal
N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the
postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the
context of spatial learning and memory (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NETO1 gene promoter:
         CP2   AML1a   FOXJ2 (long isoform)   FOXJ2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNETO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NETO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NETO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.2

NETO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NETO1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M070490:  view genomic region     (about GC identifiers)

Start:
70,409,549 bp from pter      End:
70,535,381 bp from pter
Size:
125,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5 (See protein sequence)
Recommended Name: Neuropilin and tolloid-like protein 1 precursor  
Size: 533 amino acids; 60191 Da
Subunit: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and
GRIN2B via its CUB domains (By similarity)
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction,
synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Component of the postsynaptic density
(PSD) of excitatory synapses (By similarity)
Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 1: Secreted (Potential)
Secondary accessions: Q86W85 Q8ND78 Q8TDF4
Alternative splicing: 3 isoforms:  Q8TDF5-3   Q8TDF5-1   Q8TDF5-2   

Explore the universe of human proteins at neXtProt for NETO1: NX_Q8TDF5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TDF5

  • NETO1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188394.1  NP_620416.1  NP_620552.1  

    ENSEMBL proteins: 
     ENSP00000464312   ENSP00000462993   ENSP00000313088   ENSP00000464188   ENSP00000299430  
     ENSP00000381024  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NETO1 
    GenScript Custom Purified and Recombinant Proteins Services for NETO1
    Novus Biologicals NETO1 Proteins
    Novus Biologicals NETO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NETO1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density ISS--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--


    NETO1 for ontologies           About GeneDecksing



    NETO1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NETO1
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NETO1 
    GenScript Custom Superior Antibodies Services for NETO1
    Novus Biologicals NETO1 Antibodies
    Search for Antibodies for NETO1 at Abcam  
    Uscn Antibodies for NETO1
    Search ThermoFisher Antibodies for NETO1

    Assay Products for NETO1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NETO1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NETO1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NETO1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR023415 LDLR_class-A_CS

    Graphical View of Domain Structure for InterPro Entry Q8TDF5

    ProtoNet protein and cluster: Q8TDF5

    2 Blocks protein families:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 LDL-receptor class A domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
    Function: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal
    N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the
    postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the
    context of spatial learning and memory (By similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): NETO1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NETO1
    8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate NETO1 (see all 102):
    hsa-miR-411* hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidNETO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NETO1 (see all 7)
    OriGene shRNA RFP: NETO1
    OriGene siRNA: NETO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NETO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NETO1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NETO1 (NM_138999)
    Sino Biological Human cDNA Clone for NETO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NETO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NETO1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NETO1
    Search LifeMap BioReagents cell lines for NETO1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding ----


    NETO1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Neto1tm1(KOMP)Vlcg for NETO1
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neto1):
     behavior/neurological  nervous system 

    NETO1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NETO1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for NETO1 (Q8TDF53 ENSP000003130884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783523I2D: score=1 
    GRIN1ENSP000003606164STRING: ENSP00000360616
    GRIN2BENSP000002795934STRING: ENSP00000279593
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007613memory ISS--
    GO:0008542visual learning ISS--
    GO:0048169regulation of long-term neuronal synaptic plasticity ISS--


    NETO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NETO1
    Search CenterWatch for drugs/clinical trials and news about NETO1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NETO1 gene (4 alternative transcripts): 
    NM_001201465.1  NM_138966.3  NM_138999.1  NM_153181.2  

    Unigene Cluster for NETO1:

    Neuropilin (NRP) and tolloid (TLL)-like 1
    Hs.465407  [show with all ESTs]
    Unigene Representative Sequence: NM_138966
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583169(uc002lkw.3) ENST00000582281 ENST00000327305(uc002lky.2)
    ENST00000579730 ENST00000580049 ENST00000579169 ENST00000577184 ENST00000299430
    ENST00000397929(uc002lkz.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): NETO1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NETO1
    8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate NETO1 (see all 102):
    hsa-miR-411* hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-3607-3p hsa-miR-128 hsa-miR-371-5p hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidNETO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NETO1 (see all 7)
    OriGene shRNA RFP: NETO1
    OriGene siRNA: NETO1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NETO1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NETO1 (NM_138999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NETO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NETO1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NETO1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NETO1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NETO1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NETO1

    Additional cDNA sequence: 

    AF448838.1 AF448839.1 AK123319.1 AL834354.1 BC050329.1 

    6 DOTS entries:

    DT.423170  DT.40221077  DT.105821  DT.99943064  DT.99999031  DT.91650519 

    20 AceView cDNA sequences:

    NM_138999 NM_138966 BM424062 BM811265 AF448839 NM_153181 BG704590 BC050329 
    BG497575 AL834354 AF448838 BX090080 CF147133 AW900095 R85884 AA013001 
    AA019587 BF698373 AA013000 BM172209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NETO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATTTTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NETO1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NETO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NETO1

    SOURCE GeneReport for Unigene cluster: Hs.465407

    UniProtKB/Swiss-Prot: NETO1_HUMAN, Q8TDF5
    Tissue specificity: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower
    levels in adult and fetal brain

        SABiosciences Custom PCR Arrays for NETO1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NETO1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NETO1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NETO1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NETO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NETO1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NETO11 neuropilin (NRP) and tolloid (TLL)-like 1 86.87(n)
    92.87(a)
      421018  XM_419104.3  XP_419104.3 
    lizard
    (Anolis carolinensis)
    Reptilia NETO16
    --
    89(a)
    1 ↔ 1
    4(48363601-48454731)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003313631 neuropilin and tolloid-like protein 1-like 74.69(n)
    79.14(a)
      100331363  XM_003201284.1  XP_003201332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Neto6
    Neuropilin and tolloid-like
    17(a)
    1 → many
    X(13339939-13413663)
    worm
    (Caenorhabditis elegans)
    Secernentea K03E5.13   -- 33(a)   I(3429559-3431835)   --


    ENSEMBL Gene Tree for NETO1 (if available)
    TreeFam Gene Tree for NETO1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NETO1 gene
    TLL22  CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  NETO22  MFRP2  
    TLL12  
    3 SIMAP similar genes for NETO1 using alignment to 2 protein entries:     NETO1_HUMAN (see all proteins):
    NETO2    NRP1    NRP2

    NETO1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2716 NCBI SNPs in NETO1 are shown (see all 2716    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80864981,2
    C,F,--67253207(+) ATTTGT/CTTACT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs80858961,2
    C,F,--67253432(+) TACCAC/AACACC 1 -- us2k15Minor allele frequency- A:0.13NA WA CSA 126
    rs739666941,2
    C,--67253496(+) GCCCTT/CCCCTC 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs1119596451,2
    C,--67253843(+) GGGACC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs65666771,2
    C,F,A,--67253857(+) CGCCGG/TAGCGC 1 -- us2k13Minor allele frequency- T:0.29NA 124
    rs798690331,2
    C,F,--67254543(+) GAGCAG/ACCTCC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1114206911,2
    C,--67255127(+) CCTTGT/CGGGGT 1 -- nc-transcript-variant2Minor allele frequency- C:0.05CSA WA 119
    rs1130052421,2
    C,--67255284(+) GACACG/CGCAGG 1 -- int12Minor allele frequency- C:0.07CSA WA 120
    rs798309581,2
    F,--67255401(+) ATTGAG/ACCCCC 1 -- int11Minor allele frequency- A:0.04NA 120
    rs129666771,2
    C,--67255475(+) CTCCTA/CCAGGC 1 -- int1 tfbs34Minor allele frequency- C:0.22NA WA 242

    HapMap Linkage Disequilibrium report for NETO1 (70409549 - 70535381 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for NETO1
         3 CNVs: 47897 32222 3179
         1 Indel: 73166

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NETO1
    DNA2.0 Custom Variant and Variant Library Synthesis for NETO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NETO1 for disorders           About GeneDecksing

    OMIM gene information: 607973    OMIM disorders: --

    1 disease for NETO1:    About MalaCards
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NETO1 (3 documents)

    Export disorders for NETO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NETO1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NETO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. (PubMed id 11943477)1, 2, 3, 9 Stoehr H.... Weber B.H.F. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    4. A case control association study and cognitive functio n analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japane se population. (PubMed id 22205981)1 Banno M....Ozaki N. (2011)
    5. Genetic determinants of autism in individuals with de letions of 18q. (PubMed id 20499253)1 O'Donnell L....Cody J.D. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. (PubMed id 19243221)1 Ng D....McInnes R.R. (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81832 HGNC: 13823 AceView: NETO1 Ensembl:ENSG00000166342 euGenes: HUgn81832
    ECgene: NETO1 H-InvDB: NETO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NETO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NETO1 gene:
    Search GeneIP for patents involving NETO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NETO1 (NETO1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NETO1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NETO1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NETO1  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NETO1   OriGene 3'-UTR Clone for NETO1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NETO1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NETO1   OriGene Custom Protein Services for NETO1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NETO1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NETO1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NETO1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NETO1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NETO1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NETO1
     GenScript Custom Purified and Recombinant Proteins Services for NETO1 GenScript cDNA clones with any tag delivered in your preferred vector for NETO1
     GenScript Custom Assay Services for NETO1 GenScript Custom Superior Antibodies Services for NETO1
     GenScript Custom overexpressing Cell Line Services for NETO1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NETO1 promoter
     Search Chromatin IP Primers for NETO1
     RT2 qPCR Primer Assay in human, mouse, rat NETO1
     Search GNC Networks for NETO1
     SABiosciences Custom PCR Arrays for NETO1
     Search Tocris compounds for NETO1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for NETO1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NETO1 antibodies
     NETO1 proteins
     NETO1 lysates
     Search for Antibodies for NETO1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NETO1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NETO1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NETO1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NETO1
     SwitchGear 3'UTR luciferase reporter plasmids for NETO1
     SwitchGear Promoter luciferase reporter plasmids for NETO1
     Search ThermoFisher Antibodies for NETO1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NETO1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NETO1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4