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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NET1 Gene

protein-coding   GIFtS: 65
GCID: GC10P005444

Neuroepithelial Cell Transforming 1
Alzheimer's & Parkinson's Diseases Congress
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Aliases
for NET1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Neuroepithelial Cell Transforming 11 2     P65 Net1 Proto-Oncogene Protein2
ARHGEF82 3     Rho Guanine Nucleotide Exchange Factor (GEF) 82
NET1A2     Small GTP-Binding Protein Regulator2
Guanine Nucleotide Regulatory Protein (Oncogene)2     Proto-Oncogene P65 Net13
Neuroepithelial Cell-Transforming Gene 1 Protein2     Rho Guanine Nucleotide Exchange Factor 83
Neuroepithelioma Transforming Gene 12     

External Ids:    HGNC: 145921   Entrez Gene: 102762   Ensembl: ENSG000001738487   OMIM: 6064505   UniProtKB: Q7Z6283   

Export aliases for NET1 gene to outside databases

Previous GC identifers: GC10M005513 GC10P005428 GC10P005554 GC10P005408


Summaries
for NET1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NET1 Gene:
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho
proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within
the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene
are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript
variants that encode different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for NET1 Gene: 
NET1 (neuroepithelial cell transforming 1) is a protein-coding gene. Diseases associated with NET1 include slc6a5-related hyperekplexia, and hyperekplexia, and among its related super-pathways are NRAGE signals death through JNK and Ras Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF3.

UniProtKB/Swiss-Prot: ARHG8_HUMAN, Q7Z628
Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the
SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell
death

Gene Wiki entry for NET1 Gene


Genomic Views
for NET1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NET1 gene promoter:
         STAT5B   AML1a   GATA-3   Pax-2   Pax-2a   Gfi-1   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NET1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NET1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NET1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15

NET1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NET1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005444:  view genomic region     (about GC identifiers)

Start:
 5,454,514 bp from pter      End:
 5,500,426 bp from pter
Size:
 45,913 bases      Orientation:
 plus strand

Proteins
for NET1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ARHG8_HUMAN, Q7Z628 (See protein sequence)
Recommended Name: Neuroepithelial cell-transforming gene 1 protein  
Size: 596 amino acids; 67740 Da
Subunit: Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts
with the PDZ 1 domain of BAIAP1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=AAB08847.1; Type=Frameshift; Positions=586; Sequence=AAB37683.1; Type=Frameshift;
Positions=15, 33; Sequence=CAA08974.1; Type=Frameshift; Positions=8, 55, 59, 70, 586;
1 PDB 3D structure from and Proteopedia for NET1:
3EO2 (3D)    
Secondary accessions: Q12773 Q96D82 Q99903 Q9UEN6
Alternative splicing: 2 isoforms:  Q7Z628-1   Q7Z628-2   

Explore the universe of human proteins at neXtProt for NET1: NX_Q7Z628

Explore proteomics data for NET1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z628

    • NET1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NET1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001040625.1  NP_005854.2  

    ENSEMBL proteins: 
     ENSP00000347134   ENSP00000403101   ENSP00000369717   ENSP00000446452  
    Reactome Protein details: Q7Z628
    Human Recombinant Protein Products for NET1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for NET1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NET1
    GenScript Custom Purified and Recombinant Proteins Services for NET1
    Novus Biologicals NET1 Proteins
    Novus Biologicals NET1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NET1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    NET1 for ontologies           About GeneDecksing



    NET1 Antibody Products: 
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    Novus Biologicals NET1 Antibodies
    Abcam antibodies for NET1
    Cloud-Clone Corp. Antibodies for NET1 
    ThermoFisher Antibodies for NET1
    LSBio Antibodies in human, mouse, rat for NET1 

    Assay Products for NET1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NET1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NET1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NET1 
    Cloud-Clone Corp. CLIAs for NET1

    Protein Domains /
    Families
    for NET1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    5 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR015721 RhoGEF-like
     IPR001331 GDS_CDC24_CS

    Graphical View of Domain Structure for InterPro Entry Q7Z628

    ProtoNet protein and cluster: Q7Z628

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHG8_HUMAN, Q7Z628
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    NET1 for domains           About GeneDecksing


    Function
    for NET1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHG8_HUMAN, Q7Z628
    Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the
    SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell
    death
    Induction: By TGFB1. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity TAS8649828
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    NET1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NET1:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NET1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NET1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NET1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NET1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NET1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NET1 (see all 23):
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-657 hsa-miR-3129-5p hsa-miR-132 hsa-miR-340 hsa-miR-144 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: NET1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NET1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NET1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NET1
    Sirion Biotech Customized adenovirus for overexpression of NET1

    Clone
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    OriGene clones in human, mouse for NET1 (see all 14)
    OriGene ORF clones in mouse, rat for NET1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NET1 (NM_005863)
    Sino Biological Human cDNA Clone for NET1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NET1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NET1
    Sirion Biotech Customized lentivirus for stable overexpression of NET1 
                         Customized lentivirus expression plasmids for stable overexpression of NET1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NET1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NET1


    Pathways & Interactions
    for NET1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NET1 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell death signalling via NRAGE, NRIF and NADE
    		Cell death signalling via NRAGE, NRIF and NADE0.74
    		p75 NTR receptor-mediated signalling0.73
    		NRAGE signals death through JNK0.74
    		G alpha (12/13) signalling events0.46
    2GPCR Pathway
    		Ras Pathway0.73
    		Pancreatic Adenocarcinoma0.59
    		GPCR Pathway0.62
    		Breast Cancer Regulation by Stathmin10.58
    3Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.55
    		GPCR downstream signaling0.90
    4G-AlphaQ Signaling
    		G-AlphaQ Signaling0.47
    		Thrombin Signaling0.40
    		G-AlphaI Signaling0.47
    5Rho Family GTPases
    		Rho Family GTPases0.61
    		Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NET1
        Cytoskeleton remodeling Role of PDGFs in cell migration

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NET1 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    1 GeneGo (Thomson Reuters) Pathway for NET1
        Cytoskeleton remodeling Role of PDGFs in cell migration

    1 BioSystems Pathway for NET1
        Regulation of RhoA activity


    5/10        Reactome Pathways for NET1 (see all 10)
        GPCR downstream signaling
    Signaling by Rho GTPases
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE
    Signaling by GPCR



    NET1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NET1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for NET1 (Q7Z6283 ENSP000003471344) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    MAGI1Q96QZ73, ENSP000003854504I2D: score=3 STRING: ENSP00000385450
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS8649828
    GO:0007165signal transduction TAS8649828
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032321positive regulation of Rho GTPase activity IMP--
    GO:0035023regulation of Rho protein signal transduction ----

    NET1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NET1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NET1 (ARHG8)

    3 HMDB Compounds for NET1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about NET1 / ARHG8

    Transcripts
    for NET1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NET1 gene (2 alternative transcripts): 
    NM_001047160.2  NM_005863.4  

    Unigene Cluster for NET1:

    Neuroepithelial cell transforming 1
    Hs.25155  [show with all ESTs]
    Unigene Representative Sequence: NM_001047160
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355029(uc001iia.3 uc010qar.2) ENST00000486354 ENST00000449083
    ENST00000380359(uc001iib.3 uc010qas.2) ENST00000465087 ENST00000484741
    ENST00000542715

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NET1
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate NET1 (see all 23):
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-657 hsa-miR-3129-5p hsa-miR-132 hsa-miR-340 hsa-miR-144 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: NET1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NET1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NET1
    Clone
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    OriGene ORF clones in mouse, rat for NET1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NET1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NET1
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NET1

    Additional mRNA sequence: 

    AB209852.1 AJ010046.1 AK024919.1 AK294244.1 AK299335.1 AK302687.1 AK304028.1 AK315566.1 
    BC010285.1 BC053553.1 NR_073040.1 S82401.1 U02081.1 

    18 DOTS entries:

    DT.97860210  DT.455207  DT.86838054  DT.99991536  DT.100792472  DT.455206  DT.97810157  DT.121221194 
    DT.102826903  DT.121221244  DT.95301494  DT.40279022  DT.92447449  DT.121221239  DT.121221261  DT.447089 
    DT.92384021  DT.97860209 

    24/386 AceView cDNA sequences (see all 386):

    CK429832 AL601576 BM835259 BM783408 AA831287 CA392582 BM767301 BQ925376 
    AW631462 AL079853 CB149941 AU125526 AI610995 CB851085 AU280423 BQ181013 
    CD722646 AW675637 BM822189 BC053553 BQ024362 BM771515 BG493138 BM724562 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NET1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
    SP1:                                -     -                 -           -     -                                                           -         
    SP2:                                                        -           -     -                                                           -         
    SP3:                                -     -                 -           -                                                                           
    SP4:                                      -                                                                                                         
    SP5:                                                                                                                                      -         


    ECgene alternative splicing isoforms for NET1

    Expression
    for NET1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NET1 expression in normal human tissues (normalized intensities)      NET1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGGCTTG
    NET1 Expression
    About this image


    NET1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             trachea   
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Colon (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)

    See NET1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NET1

    SOURCE GeneReport for Unigene cluster: Hs.25155

    UniProtKB/Swiss-Prot: ARHG8_HUMAN, Q7Z628
    Tissue specificity: Widely expressed

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    In Situ
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NET1

    Orthologs
    for NET1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NET1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Net11 , 5 neuroepithelial cell transforming gene 11, 5 85.32(n)1
    87.06(a)1    		   13 (2.17 cM)5
    563491  NM_019671.21  NP_062645.21 
     38825655 
    chicken
    (Gallus gallus)    		 Aves NET11 neuroepithelial cell transforming 1 75.21(n)
    78.94(a)    		   416693  NM_001030648.1  NP_001025819.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NET16
    		 neuroepithelial cell transforming 1
    		 74(a)
    		 1 ↔ 1
    		 GL343728.1(88759-176566)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC042313.12   -- 78.49(n)    BC042313.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii net11 neuroepithelial cell transforming gene 1 64.15(n)
    69.05(a)    		   493607  NM_001007767.1  NP_001007768.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gef64C6
    		 Guanine nucleotide exchange factor GEF64C
    		 4(a)
    		 possible ortholog
    		 3L(4692783-4796253)


    ENSEMBL Gene Tree for NET1 (if available)
    TreeFam Gene Tree for NET1 (if available)

    Paralogs
    for NET1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NET1 gene
    ARHGEF32  
    8 SIMAP similar genes for NET1 using alignment to 5 protein entries:     ARHG8_HUMAN (see all proteins):
    ARHGEF3    BCR/ABL fusion    PREX1    ITSN1    PREX2    ARHGEF12
    ARHGEF1    ITSN2

    NET1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NET1
    PGOHUM00000235063 PGOHUM00000245126 PGOHUM00000233408


    Genomic Variants
    for NET1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in NET1 are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0359724
    		A breast cancer sample4--see VAR_0359722 D N mis40--------
    rs114634711,2
    		C--5452533(+) ACTCT-/TAACTG 1 -- us2k10--------
    rs1390346461,2
    		--5452584(+) ATGGGA/GAAGGT 1 -- us2k10--------
    rs1829920191,2
    		--5452644(+) CCTTCC/TGGTGG 1 -- us2k10--------
    rs1873573961,2
    		--5452743(+) GAGCAG/TCAGCA 1 -- us2k10--------
    rs607131841,2
    		C,F--5452758(+) TTATTG/ATAAAG 1 -- us2k13Minor allele frequency- A:0.29WA 122
    rs1910505131,2
    		--5452793(+) GTGTGA/GAAGGG 1 -- us2k10--------
    rs758297241,2
    		C--5452799(+) CAGGGT/GACCCG 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1840937481,2
    		--5452898(+) TTTTTA/TCAATC 1 -- us2k10--------
    rs1885960561,2
    		--5453094(+) TCAATG/TTTACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NET1 (5454514 - 5500426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NET1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731718CNV Deletion23290073
    nsv894783CNV Loss21882294
    dgv600n71CNV Loss21882294
    nsv831774CNV Gain17160897
    nsv894792CNV Gain21882294

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    Disorders / Diseases
    for NET1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606450    OMIM disorders: --

    11 diseases for NET1:    About MalaCards
    slc6a5-related hyperekplexia    hyperekplexia    neuroepithelioma    attention deficit hyperactivity disorder
    gastric cancer    alzheimer's disease    hepatocellular carcinoma    adenocarcinoma
    breast cancer    pancreatitis    leukemia


    NET1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NET1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroepithelioma 87.5 3 15611121 (1), 19124484 (1), 8649828 (1)

    Genetic Association Database (GAD): NET1
    Human Genome Epidemiology (HuGE) Navigator: NET1 (97 documents)

    Export disorders for NET1 gene to outside databases

    Publications
    for NET1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NET1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with NET1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning. (PubMed id 8649828)1, 2, 3, 9 Chan A.M.-L.... Miki T. (1996)
    2. The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. (PubMed id 21373644)1, 2 Srougi M.C. and Burridge K. (2011)
    3. Lack of influence of COMT and NET genes variants on executive functions in schizophrenic and bipolar patients, their first-degree relatives and controls. (PubMed id 16741933)1, 4 Szoke A....Leboyer M. (2006)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. Support for association between ADHD and two candidate genes: NET1 and DRD1. (PubMed id 15717291)1, 4 Bobb A.J....Rapoport J.L. (2005)
    6. DNA pooling analysis of 21 norepinephrine transporter gene SNPs with attention deficit hyperactivity disorder: no evidence for association. (PubMed id 15719398)1, 4 Xu X....Asherson P. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. (PubMed id 11278519)1, 2 Shen X.... Wang X.-F. (2001)
    9. Interaction of the RhoA exchange factor Net1 with dis cs large homolog 1 protects it from proteasome-mediated degradation and potenti ates Net1 activity. (PubMed id 19586902)1, 9 Carr H.S....Frost J.A. (2009)
    10. Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma. (PubMed id 18214716)1, 9 Shen S.Q....Nakao A. (2008)

    External Searches for NET1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NET1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10276 HGNC: 14592 AceView: NET1 Ensembl:ENSG00000173848 euGenes: HUgn10276
    ECgene: NET1 H-InvDB: NET1

    Other Databases showing NET1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NET1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NET1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NET1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NET1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NET1 gene:
    Search GeneIP for patents involving NET1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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