Aliases for NET1 Gene
External Ids for NET1 Gene
Previous GeneCards Identifiers for NET1 Gene
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for NET1 Gene
NET1 (Neuroepithelial Cell Transforming 1) is a Protein Coding gene. Diseases associated with NET1 include Skin Squamous Cell Carcinoma and Breast Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and GTP-Rho binding. An important paralog of this gene is ARHGEF3.
UniProtKB/Swiss-Prot for NET1 Gene
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.