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Aliases for NET1 Gene

Aliases for NET1 Gene

  • Neuroepithelial Cell Transforming 1 2 3
  • ARHGEF8 3 4
  • Guanine Nucleotide Regulatory Protein (Oncogene) 3
  • Neuroepithelial Cell-Transforming Gene 1 Protein 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 8 3
  • Rho Guanine Nucleotide Exchange Factor 8 4
  • Neuroepithelioma Transforming Gene 1 3
  • Small GTP-Binding Protein Regulator 3
  • P65 Net1 Proto-Oncogene Protein 3
  • Proto-Oncogene P65 Net1 4
  • NET1A 3

External Ids for NET1 Gene

Previous GeneCards Identifiers for NET1 Gene

  • GC10M005513
  • GC10P005428
  • GC10P005554
  • GC10P005408

Summaries for NET1 Gene

Entrez Gene Summary for NET1 Gene

  • This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NET1 Gene

NET1 (Neuroepithelial Cell Transforming 1) is a Protein Coding gene. Diseases associated with NET1 include orthostatic intolerance and skin squamous cell carcinoma. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF11.

UniProtKB/Swiss-Prot for NET1 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Gene Wiki entry for NET1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NET1 Gene

Genomics for NET1 Gene

Regulatory Elements for NET1 Gene

Genomic Location for NET1 Gene

Start:
5,412,551 bp from pter
End:
5,459,056 bp from pter
Size:
46,506 bases
Orientation:
Plus strand

Genomic View for NET1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NET1 Gene

Proteins for NET1 Gene

  • Protein details for NET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z628-ARHG8_HUMAN
    Recommended name:
    Neuroepithelial cell-transforming gene 1 protein
    Protein Accession:
    Q7Z628
    Secondary Accessions:
    • Q12773
    • Q96D82
    • Q99903
    • Q9UEN6

    Protein attributes for NET1 Gene

    Size:
    596 amino acids
    Molecular mass:
    67740 Da
    Quaternary structure:
    • Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1 (By similarity).
    SequenceCaution:
    • Sequence=AAB08847.1; Type=Frameshift; Positions=586; Evidence={ECO:0000305}; Sequence=AAB37683.1; Type=Frameshift; Positions=15, 33; Evidence={ECO:0000305}; Sequence=CAA08974.1; Type=Frameshift; Positions=8, 55, 59, 70, 586; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NET1 Gene

    Alternative splice isoforms for NET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NET1 Gene

Proteomics data for NET1 Gene at MOPED

Post-translational modifications for NET1 Gene

  • Ubiquitination at Lys194, Lys301, and Lys489
  • Modification sites at PhosphoSitePlus

Other Protein References for NET1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NET1 Gene

Domains for NET1 Gene

Gene Families for NET1 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for NET1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z628

UniProtKB/Swiss-Prot:

ARHG8_HUMAN :
  • Q7Z628
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with NET1: view

Function for NET1 Gene

Molecular function for NET1 Gene

UniProtKB/Swiss-Prot Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
UniProtKB/Swiss-Prot Induction: By TGFB1. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).

Gene Ontology (GO) - Molecular Function for NET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS 8649828
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0017049 GTP-Rho binding IEA --
genes like me logo Genes that share ontologies with NET1: view
genes like me logo Genes that share phenotypes with NET1: view

miRNA for NET1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NET1 Gene

Localization for NET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NET1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NET1 Gene COMPARTMENTS Subcellular localization image for NET1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NET1: view

Pathways for NET1 Gene

genes like me logo Genes that share pathways with NET1: view

Gene Ontology (GO) - Biological Process for NET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8649828
GO:0007165 signal transduction TAS 8649828
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0035556 intracellular signal transduction --
genes like me logo Genes that share ontologies with NET1: view

Compounds for NET1 Gene

(3) HMDB Compounds for NET1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with NET1: view

Transcripts for NET1 Gene

Unigene Clusters for NET1 Gene

Neuroepithelial cell transforming 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NET1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: - -
SP7: - - - - - - - - -
SP8: -
SP9:
SP10:

Relevant External Links for NET1 Gene

GeneLoc Exon Structure for
NET1
ECgene alternative splicing isoforms for
NET1

Expression for NET1 Gene

mRNA expression in normal human tissues for NET1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NET1 Gene

SOURCE GeneReport for Unigene cluster for NET1 Gene Hs.25155

mRNA Expression by UniProt/SwissProt for NET1 Gene

Q7Z628-ARHG8_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with NET1: view

No data available for mRNA differential expression in normal tissues for NET1 Gene

Orthologs for NET1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NET1 35
  • 99.27 (n)
  • 99.33 (a)
NET1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NET1 35
  • 82.17 (n)
  • 82.36 (a)
NET1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NET1 35
  • 85.38 (n)
  • 86.59 (a)
NET1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Net1 35
  • 85.32 (n)
  • 87.06 (a)
Net1 16
Net1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NET1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Net1 35
  • 84.47 (n)
  • 87.08 (a)
chicken
(Gallus gallus)
Aves NET1 35
  • 76.6 (n)
  • 80.78 (a)
NET1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NET1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia net1 35
  • 71.29 (n)
  • 74.82 (a)
Str.5900 35
zebrafish
(Danio rerio)
Actinopterygii net1 35
  • 64.94 (n)
  • 70.92 (a)
net1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gef64C 36
  • 4 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 36
  • 7 (a)
ManyToMany
ROM1 38
ROM2 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for NET1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NET1 Gene

ENSEMBL:
Gene Tree for NET1 (if available)
TreeFam:
Gene Tree for NET1 (if available)

Paralogs for NET1 Gene

Selected SIMAP similar genes for NET1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NET1 Gene

genes like me logo Genes that share paralogs with NET1: view

Variants for NET1 Gene

Sequence variations from dbSNP and Humsavar for NET1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs11791 -- 5,457,210(+) CTTGA(A/G)TTATT utr-variant-3-prime, nc-transcript-variant
rs1128821 -- 5,457,716(+) tatgt(G/T)tgtgt utr-variant-3-prime, nc-transcript-variant
rs1128822 -- 5,457,719(+) gtgtg(C/T)gtgtg utr-variant-3-prime, nc-transcript-variant
rs1802554 -- 5,457,587(+) AACCT(G/T)CCGAT utr-variant-3-prime, nc-transcript-variant
rs3923347 -- 5,414,779(+) AGGCA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NET1 Gene

Variant ID Type Subtype PubMed ID
nsv894783 CNV Loss 21882294
nsv894792 CNV Gain 21882294
nsv831774 CNV Gain 17160897
esv2731718 CNV Deletion 23290073
dgv600n71 CNV Loss 21882294

Relevant External Links for NET1 Gene

HapMap Linkage Disequilibrium report
NET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NET1 Gene

Disorders for NET1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NET1 Gene including...

Search for NET1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for NET1 Gene

Disease -log(P) Hits PubMed IDs
neuroepithelioma 87.5 3

Relevant External Links for NET1

Genetic Association Database (GAD)
NET1
Human Genome Epidemiology (HuGE) Navigator
NET1
genes like me logo Genes that share disorders with NET1: view

No data available for UniProtKB/Swiss-Prot for NET1 Gene

Publications for NET1 Gene

  1. Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning. (PMID: 8649828) Chan A.M.-L. … Miki T. (Oncogene 1996) 2 3 4 23
  2. The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. (PMID: 17938206) GarcA-a-Mata R. … Burridge K. (Mol. Cell. Biol. 2007) 3 23
  3. Expression and clinical significance of NET-1 and PCNA in hepatocellular carcinoma. (PMID: 18214716) Shen S.Q. … Nakao A. (Med. Oncol. 2008) 3 23
  4. A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. (PMID: 18509476) Guerra L. … Frisan T. (PLoS ONE 2008) 3 23
  5. NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer. (PMID: 18827818) Murray D. … Doran P. (Br. J. Cancer 2008) 3 23

Products for NET1 Gene

  • Addgene plasmids for NET1

Sources for NET1 Gene

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