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Aliases for NES Gene

Aliases for NES Gene

  • Nestin 2 3 3 5
  • Nbla00170 3

External Ids for NES Gene

Previous GeneCards Identifiers for NES Gene

  • GC00U990485
  • GC01M153416
  • GC01M153855
  • GC01M153451
  • GC01M154905
  • GC01M156639
  • GC01M127996

Summaries for NES Gene

Entrez Gene Summary for NES Gene

  • This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

GeneCards Summary for NES Gene

NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Brain Stem Cancer and Ependymoblastoma. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is SYNM.

UniProtKB/Swiss-Prot for NES Gene

  • Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Wiki entry for NES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NES Gene

Genomics for NES Gene

Regulatory Elements for NES Gene

Enhancers for NES Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156672 1 FANTOM5 ENCODE 21.5 +1.7 1717 6.1 PKNOX1 SIN3A ARID4B ZNF2 GLIS2 ZNF143 KLF7 ZNF263 SP3 SP5 NES ENSG00000272068 GC01P156668
GH01F156656 1.7 VISTA FANTOM5 Ensembl ENCODE 7.2 +13.1 13139 15.3 CREB3L1 MLX ZFP64 DMAP1 ZNF416 ZNF143 ZNF263 MCM3 SP3 SSRP1 MSTO2P ENSG00000229961 ENSG00000233712 KIAA0907 TSACC RRNAD1 ENSG00000272405 SSR2 GLMP LOC246784
GH01F156684 1.1 Ensembl ENCODE 0.4 -7.2 -7227 1.1 CTCF JUND IKZF1 MAFG NFE2 ZNF652 PRDM1 RAD21 SPI1 ENSG00000272068 ENSG00000237588 NES
GH01F156686 0.2 ENCODE 0.4 -9.1 -9067 0.2 JUND POLR2A CEBPA CEBPB FOS THRB TCF7L2 ENSG00000237588 NES
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NES on UCSC Golden Path with GeneCards custom track

Promoters for NES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001525051 797 2801 PKNOX1 ZFP64 SIN3A ARID4B ZNF2 GLIS2 ZNF143 KLF7 ZNF263 SP3

Genomic Location for NES Gene

Chromosome:
1
Start:
156,668,763 bp from pter
End:
156,677,397 bp from pter
Size:
8,635 bases
Orientation:
Minus strand

Genomic View for NES Gene

Genes around NES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NES Gene

Proteins for NES Gene

  • Protein details for NES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48681-NEST_HUMAN
    Recommended name:
    Nestin
    Protein Accession:
    P48681
    Secondary Accessions:
    • O00552
    • Q3LIF5
    • Q5SYZ6

    Protein attributes for NES Gene

    Size:
    1621 amino acids
    Molecular mass:
    177439 Da
    Quaternary structure:
    • Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity).

neXtProt entry for NES Gene

Post-translational modifications for NES Gene

  • Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NES Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NES Gene

Domains & Families for NES Gene

Gene Families for NES Gene

Protein Domains for NES Gene

Suggested Antigen Peptide Sequences for NES Gene

Graphical View of Domain Structure for InterPro Entry

P48681

UniProtKB/Swiss-Prot:

NEST_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with NES: view

Function for NES Gene

Molecular function for NES Gene

UniProtKB/Swiss-Prot Function:
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Ontology (GO) - Molecular Function for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0019215 intermediate filament binding ISS --
genes like me logo Genes that share ontologies with NES: view
genes like me logo Genes that share phenotypes with NES: view

Animal Model Products

miRNA for NES Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NES

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NES Gene

Localization for NES Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NES Gene COMPARTMENTS Subcellular localization image for NES gene
Compartment Confidence
cytoskeleton 5
nucleus 4
extracellular 2
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19384922
GO:0005882 intermediate filament NAS 9917366
GO:0031012 extracellular matrix IDA 23979707
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NES: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NES Gene

Pathways & Interactions for NES Gene

genes like me logo Genes that share pathways with NES: view

Gene Ontology (GO) - Biological Process for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007417 central nervous system development NAS 9917366
GO:0007420 brain development ISS --
genes like me logo Genes that share ontologies with NES: view

No data available for SIGNOR curated interactions for NES Gene

Drugs & Compounds for NES Gene

(12) Drugs for NES Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(15) Additional Compounds for NES Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NES: view

Transcripts for NES Gene

mRNA/cDNA for NES Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(49) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NES Gene

Nestin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NES

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NES Gene

No ASD Table

Relevant External Links for NES Gene

GeneLoc Exon Structure for
NES
ECgene alternative splicing isoforms for
NES

Expression for NES Gene

mRNA expression in normal human tissues for NES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NES Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.0) and Heart - Left Ventricle (x4.7).

Protein differential expression in normal tissues from HIPED for NES Gene

This gene is overexpressed in Fetal Brain (18.4) and Fetal heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NES Gene



Protein tissue co-expression partners for NES Gene

NURSA nuclear receptor signaling pathways regulating expression of NES Gene:

NES

SOURCE GeneReport for Unigene cluster for NES Gene:

Hs.527971

mRNA Expression by UniProt/SwissProt for NES Gene:

P48681-NEST_HUMAN
Tissue specificity: CNS stem cells.
genes like me logo Genes that share expression patterns with NES: view

Primer Products

Orthologs for NES Gene

This gene was present in the common ancestor of chordates.

Orthologs for NES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NES 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia NES 34 35
  • 79.21 (n)
cow
(Bos Taurus)
Mammalia NES 35
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nes 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NES 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NES 35
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nes 35
  • 17 (a)
OneToOne
Species where no ortholog for NES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NES Gene

ENSEMBL:
Gene Tree for NES (if available)
TreeFam:
Gene Tree for NES (if available)

Paralogs for NES Gene

Paralogs for NES Gene

(1) SIMAP similar genes for NES Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NES: view

Variants for NES Gene

Sequence variations from dbSNP and Humsavar for NES Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs114406081 Benign 156,672,363(+) AGCCT(C/G)TTTTT reference, missense
rs1046650 -- 156,669,208(-) ACATA(C/T)GGTTT utr-variant-3-prime
rs1046694 -- 156,668,880(-) GCCGT(C/T)TGGCC utr-variant-3-prime
rs111436671 -- 156,673,088(+) GCACA(A/G)GTGTC reference, missense
rs111737324 -- 156,676,644(+) TCGCG(C/G)GCCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NES Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV loss 19592680

Variation tolerance for NES Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NES Gene

Human Gene Mutation Database (HGMD)
NES
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NES Gene

Disorders for NES Gene

MalaCards: The human disease database

(44) MalaCards diseases for NES Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain stem cancer
  • malignant neoplasm of brain stem
ependymoblastoma
optic nerve glioma
  • glioma of the optic nerve
periventricular leukomalacia
  • pvl
medulloepithelioma
  • diktyoma, malignant
- elite association - COSMIC cancer census association via MalaCards
Search NES in MalaCards View complete list of genes associated with diseases

Relevant External Links for NES

Genetic Association Database (GAD)
NES
Human Genome Epidemiology (HuGE) Navigator
NES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NES
genes like me logo Genes that share disorders with NES: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NES Gene

Publications for NES Gene

  1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PMID: 1478958) Dahlstrand J. … Lendahl U. (J. Cell Sci. 1992) 2 3 4 64
  2. Nestin expression in glial and neuronal progenitors of the developing human spinal ganglia. (PMID: 20044038) Vukojevic K. … Saraga-Babic M. (Gene Expr. Patterns 2010) 3 22 64
  3. Heterogeneous expression of nestin in myofibroblasts of various human tissues. (PMID: 20518888) Kishaba Y. … Niki T. (Pathol. Int. 2010) 3 22 64
  4. The stem cell marker nestin predicts poor prognosis in human melanoma. (PMID: 19956860) Piras F. … Sirigu P. (Oncol. Rep. 2010) 3 22 64
  5. Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. (PMID: 20132963) Chen Z. … Xiang A.P. (Hum. Pathol. 2010) 3 22 64

Products for NES Gene

Sources for NES Gene

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