External Ids for NES Gene
Previous GeneCards Identifiers for NES Gene
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
GeneCards Summary for NES Gene
NES (Nestin) is a Protein Coding gene. Diseases associated with NES include central nervous system germ cell tumor and optic nerve glioma. Among its related pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is SYNM.
UniProtKB/Swiss-Prot for NES Gene
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).