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NES Gene

protein-coding   GIFtS: 58
GCID: GC01M156639

Nestin

  See NES-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
nestin1 2

External Ids:    HGNC: 77561   Entrez Gene: 107632   Ensembl: ENSG000001326887   OMIM: 6009155   UniProtKB: P486813   

Export aliases for NES gene to outside databases

Previous GC identifers: GC00U990485 GC01M153416 GC01M153855 GC01M153451 GC01M154905 GC01M127996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NES Gene:
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.
(provided by RefSeq, Sep 2011)

GeneCards Summary for NES Gene:
NES (nestin) is a protein-coding gene. Diseases associated with NES include anaplastic oligoastrocytoma, and brain ischemia. GO annotations related to this gene include intermediate filament binding and structural molecule activity. An important paralog of this gene is SYNM.

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate
filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other
cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and
mitogen-stimulated proliferation of neural progenitor cells (By similarity)

Gene Wiki entry for NES (Nestin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NES gene promoter:
         AhR   Bach1   RP58   Pax-5   Olf-1   Tal-1beta   Ik-3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNES promoter sequence
   Search Chromatin IP Primers for NES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23

NES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NES gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156639:  view genomic region     (about GC identifiers)

Start:
156,638,555 bp from pter      End:
156,647,189 bp from pter
Size:
8,635 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEST_HUMAN, P48681 (See protein sequence)
Recommended Name: Nestin  
Size: 1621 amino acids; 177439 Da
Subunit: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such
as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form
intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity)
Developmental stage: Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments
Secondary accessions: O00552 Q3LIF5 Q5SYZ6

Explore the universe of human proteins at neXtProt for NES: NX_P48681

Explore proteomics data for NES at MOPED

Post-translational modifications: 

  • Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is
    reorganized (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006608.1  
    ENSEMBL proteins: 
     ENSP00000357206  

    NES Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NES
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NES

     
    Search eBioscience for Proteins for NES 

    NES Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NES
    R&D Systems Antibodies for NES (Nestin)
    OriGene Antibodies for NES
    OriGene Custom Antibody Services for NES
    Novus Biologicals NES Antibodies
    Abcam antibodies for NES
    Cloud-Clone Corp. Antibodies for NES
    ThermoFisher Antibody for NES
    LSBio Antibodies in human, mouse, rat for NES

    NES Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NES
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NES
    Cloud-Clone Corp. CLIAs for NES
    Search eBioscience for ELISAs for NES 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF4: Intermediate filaments type IV

    2 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF

    Graphical View of Domain Structure for InterPro Entry P48681

    ProtoNet protein and cluster: P48681

    UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with NES           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEST_HUMAN, P48681
    Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate
    filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other
    cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and
    mitogen-stimulated proliferation of neural progenitor cells (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
    GO:0019215intermediate filament binding ISS--
         
    Find genes that share ontologies with NES           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NES:
     Lamellipodia cells 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nes):
     behavior/neurological  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system 

    Find genes that share phenotypes with NES           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NES: Nestm1Nagy Nestm1Dopa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NES
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NES
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NES

    miRNA
    Products:
        
    miRTarBase miRNAs that target NES:
    hsa-mir-125b-5p (MIRT035540), hsa-mir-155-5p (MIRT020595)

    Block miRNA regulation of human, mouse, rat NES using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NES
    SwitchGear 3'UTR luciferase reporter plasmidNES 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NES
    Predesigned siRNA for gene silencing in human, mouse, rat NES

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NES

    Clone
    Products:
         
    OriGene clones in human, mouse for NES (see all 7)
    OriGene ORF clones in mouse, rat for NES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES
    Addgene plasmids for NES 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NES 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13125 VA6-11410) for NES 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA19384922
    GO:0005882intermediate filament NAS9917366
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with NES           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NES About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoskeleton remodeling Neurofilaments0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NES
        Cytoskeleton remodeling Neurofilaments


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NES: 
              Notch Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for NES (P486813 ENSP000003572064) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    CDK5R1Q150783, ENSP000003184864I2D: score=2 STRING: ENSP00000318486
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    CDK1P064933I2D: score=1 
    TGFBR2ENSP000003519054STRING: ENSP00000351905
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA19384922
    GO:0007399nervous system development ----
    GO:0007417central nervous system development NAS9917366
    GO:0007420brain development ISS--
    GO:0030844positive regulation of intermediate filament depolymerization ISS--

    Find genes that share ontologies with NES           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NES (NEST)

    Selected Novoseek inferred chemical compound relationships for NES gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tanabin 83.1 5 17854500 (3), 10636467 (1), 9361289 (1)
    bromodeoxyuridine 62.1 38 16902995 (3), 10686078 (1), 18693285 (1), 15269271 (1) (see all 15)
    retinoic acid 55.2 18 8522959 (1), 15530878 (1), 17335085 (1), 16195347 (1) (see all 14)
    gaba 35.1 10 12724646 (3), 19223540 (1), 20479529 (1), 15473979 (1) (see all 5)
    vegf 30.6 16 19473053 (3), 17611402 (2), 12781997 (1), 17027979 (1) (see all 10)
    2-mercaptoethanol 30.2 2 17046576 (1), 16336835 (1)
    c-peptide 29.8 2 15602695 (2)
    temozolomide 21.9 1 18817556 (1)
    matrigel 21.8 2 10571412 (1), 16495796 (1)
    glutamate 18.4 3 18629509 (1), 12786777 (1), 20452788 (1)



    Find genes that share compounds with NES           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NES gene: 
    NM_006617.1  

    Unigene Cluster for NES:

    Nestin
    Hs.527971  [show with all ESTs]
    Unigene Representative Sequence: NM_006617
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368223(uc001fpq.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NES using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidNES 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NES
    Clone
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    OriGene ORF clones in mouse, rat for NES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES
    Addgene plasmids for NES 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NES
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      QuantiFast Probe-based Assays in human, mouse, rat NES
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13125 VA6-11410) for NES 

    Additional mRNA sequence: 

    AB073350.1 AF086454.1 AK025494.1 BC032580.1 BC051373.1 BC108285.1 BC142611.1 

    6 DOTS entries:

    DT.446554  DT.121422934  DT.95304497  DT.100752302  DT.95159044  DT.91681816 

    Selected AceView cDNA sequences (see all 49):

    BX645147 BQ638119 BX119194 BC051373 NM_006617 AA953545 AI934601 AI253123 
    BM451320 BQ953465 BI816812 BC032580 BX353453 AL133969 BU931678 BG912782 
    AU252483 AW168445 BU554136 BU856484 BU931101 BF509846 T28212 BX479858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGACTCC
    NES Expression
    About this image


    NES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Meningeal Cells Anterior Meninges
             Cerebellum
             Neural stem cells LewisX+ CXCR4+
             Neural progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Diencephalon
             Neural rosettes
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Fetal spinal cord stem cells (NSI-566)
             Motor neuron-like precursor cells
     
     NULL (Uncategorized)    fully expand to see all 13 entries
             Fibroblast-induced cells
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Wharton's Jelly
             Placenta-derived mesenchymal stem cells
    NES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NES Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527971

    UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
    Tissue specificity: CNS stem cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NES: 
              Notch Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NES
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NES gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nes5 nestin   --   3 (38.78 cM) 87971078 
    chicken
    (Gallus gallus)
    Aves NES6
    nestin
    19(a)
    1 ↔ 1
    25(483723-490804)
    African clawed frog
    (Xenopus laevis)
    Amphibia M99387.12   -- 77.59(n)    M99387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nes6
    nestin
    17(a)
    1 ↔ 1
    16(31272001-31282459) ENSDARG00000088805


    ENSEMBL Gene Tree for NES (if available)
    TreeFam Gene Tree for NES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NES gene
    SYNM2  
    1 SIMAP similar gene for NES using alignment to 5 protein entries:     NEST_HUMAN (see all proteins):
    DES

    Find genes that share paralogs with NES           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NES (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678342121,2
    C--128005374(+) GGATA-/AC/ACAC/
    ACACACACAC
    CACAC
    1 -- us2k10--------
    rs112645141,2
    C,F,A,H--128006775(+) CCTCCC/TAAAGT 1 -- us2k17Minor allele frequency- T:0.39NA WA 18
    rs355221041,2
    C--156638211(+) TAATG-/GGGGGG 1 -- ds50010--------
    rs589486701,2
    C--156647776(+) CACAC-/ACACAC
    ACACACAC
    GCACA
    1 -- us2k11Minor allele frequency- ACACACACACACAC:0.00NA 2
    rs1880061871,2
    --163136752(+) ACCCTA/GCTCCC 1 -- ds50010--------
    rs1174545521,2
    F--163136769(+) TCAGGC/TTGAGG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1928414571,2
    --163136848(+) CTAATG/TGGGGG 1 -- ds50010--------
    rs1844278801,2
    --163136903(+) TCAGTA/TCTGTG 1 -- ds50010--------
    rs75121901,2
    C,F--163137004(+) AGGCCC/TCAGCA 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs115856201,2
    C,H--163137072(+) GGAGGC/TAGCCC 1 -- ds50014Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for NES (156638555 - 156647189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NES:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872473CNV Loss21882294
    nsv523181CNV Loss19592680

    Human Gene Mutation Database (HGMD): NES
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NES
    DNA2.0 Custom Variant and Variant Library Synthesis for NES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600915    OMIM disorders: --

    Selected diseases for NES (see all 29):    
    About MalaCards
    anaplastic oligoastrocytoma    brain ischemia    periventricular leukomalacia    papillary glioneuronal tumor
    oligoastrocytoma    leukomalacia    medulloepithelioma    anaplastic ganglioglioma
    pituitary infarct    central neurocytoma    subependymoma    optic nerve glioma
    central nervous system germ cell tumor    brain glioma    glioblastoma multiforme    subependymal giant cell astrocytoma
    dysembryoplastic neuroepithelial tumor    anaplastic astrocytoma    ganglioglioma    hemangioblastoma

    7 diseases from the University of Copenhagen DISEASES database for NES:
    Malignant glioma     Brain cancer     Cerebrovascular accident     Medulloblastoma
    Teratoma     Parkinson's disease     Embryonal carcinoma

    Find genes that share disorders with NES           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NES gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain stem tumors 71.2 3 16480595 (1), 20368050 (1), 18092184 (1)
    glioblastoma 68.6 23 16529857 (2), 16457706 (2), 19082452 (2), 10640425 (1) (see all 15)
    glioma 68.1 40 17537489 (3), 17611402 (2), 18282166 (2), 17873113 (2) (see all 29)
    neuroepithelial tumors 66 5 1538585 (2), 16529857 (1), 17611402 (1), 18998057 (1)
    brain tumors 52.6 9 17537489 (1), 1538585 (1), 17456355 (1), 15805284 (1) (see all 8)
    carcinoma embryonal 51.3 4 17234757 (1), 19221495 (1), 18092184 (1)
    glioblastoma multiforme 49.8 6 16457706 (2), 17127461 (1), 19087689 (1), 9850047 (1)
    tumors 48.4 180 20429619 (6), 18925963 (6), 1382841 (5), 20425043 (5) (see all 79)
    cns tumors 48.1 12 1382841 (4), 11799134 (3), 17537489 (1), 8947955 (1) (see all 6)
    teratoma 45.9 2 15127288 (1), 18611917 (1)

    Genetic Association Database (GAD): NES
    Human Genome Epidemiology (HuGE) Navigator: NES (1 document)

    Export disorders for NES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NES gene, integrated from 10 sources (see all 671):
    (articles sorted by number of sources associating them with NES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PubMed id 1478958)1, 2, 3 Dahlstrand J.... Lendahl U. (J. Cell Sci. 1992)
    2. Variants in the nestin gene and coronary heart disease. (PubMed id 18724036)1, 4 Meng W....McKeown P.P. (Circ. J. 2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. (PubMed id 9917366)1, 2 Yaworsky P.J. and Kappen C. (Dev. Biol. 1999)
    5. An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells. (PubMed id 9104587)1, 3 Lothian C. and Lendahl U. (Eur. J. Neurosci. 1997)
    6. Expression of nestin in rat and human glomerular podocytes. (PubMed id 17784648)1, 9 Ishizaki M....Fukuda Y. (J. Submicrosc. Cytol. Pathol. 2006)
    7. Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)1, 9 Sahlgren C.M....Eriksson J.E. (Mol. Cell. Biol. 2003)
    8. Expression of nestin in the podocytes of normal and diseased human kidneys. (PubMed id 17255215)1, 9 Su W....Hao C.M. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007)
    9. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. (PubMed id 17036052)1, 9 Sahlgren C.M....Eriksson J.E. (EMBO J. 2006)
    10. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. (PubMed id 11278541)1, 9 Sahlgren C.M....Eriksson J.E. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10763 HGNC: 7756 AceView: NES Ensembl:ENSG00000132688 euGenes: HUgn10763
    ECgene: NES H-InvDB: NES

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NES Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NES gene:
    Search GeneIP for patents involving NES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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