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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NES Gene

protein-coding   GIFtS: 58
GCID: GC01M156639

Nestin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
nestin1 2

External Ids:    HGNC: 77561   Entrez Gene: 107632   Ensembl: ENSG000001326887   OMIM: 6009155   UniProtKB: P486813   

Export aliases for NES gene to outside databases

Previous GC identifers: GC00U990485 GC01M153416 GC01M153855 GC01M153451 GC01M154905 GC01M127996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NES Gene:
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.
(provided by RefSeq, Sep 2011)

GeneCards Summary for NES Gene: 
NES (nestin) is a protein-coding gene. Diseases associated with NES include oligoastrocytoma, and anaplastic ganglioglioma, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include intermediate filament binding and molecular_function. An important paralog of this gene is SYNM.

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate
filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other
cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and
mitogen-stimulated proliferation of neural progenitor cells (By similarity)

Gene Wiki entry for NES (Nestin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NES gene promoter:
         AhR   Bach1   RP58   Pax-5   Olf-1   Tal-1beta   Ik-3   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNES promoter sequence
   Search SABiosciences Chromatin IP Primers for NES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23

NES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NES gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156639:  view genomic region     (about GC identifiers)

Start:
156,638,555 bp from pter      End:
156,647,189 bp from pter
Size:
8,635 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681 (See protein sequence)
Recommended Name: Nestin  
Size: 1621 amino acids; 177439 Da
Subunit: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such
as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form
intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity)
Developmental stage: Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments
Secondary accessions: O00552 Q3LIF5 Q5SYZ6

Explore the universe of human proteins at neXtProt for NES: NX_P48681

Explore proteomics data for NES at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is
    reorganized (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48681

  • NES Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NES Protein Expression
    REFSEQ proteins: NP_006608.1  
    ENSEMBL proteins: 
     ENSP00000357206  

    Human Recombinant Protein Products for NES: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NES
    GenScript Custom Purified and Recombinant Proteins Services for NES
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NES 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA19384922
    GO:0005882intermediate filament NAS9917366
    GO:0045111intermediate filament cytoskeleton IDA--

    NES for ontologies           About GeneDecksing



    NES Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NES
    R&D Systems Antibodies for NES (Nestin)
    OriGene Antibodies for NES
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    GenScript Superior Antibodies for NES
    Novus Biologicals NES Antibodies
    Abcam antibodies for NES
    Cloud-Clone Corp. Antibodies for NES 
    ThermoFisher Antibody for NES
    LSBio Antibodies in human, mouse, rat for NES 

    Assay Products for NES: 
    EMD Millipore Kits and Assays for the Analysis of NES
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NES
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NES 
    Cloud-Clone Corp. CLIAs for NES


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF4: Intermediate filaments type IV

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry P48681

    ProtoNet protein and cluster: P48681

    UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
    Similarity: Belongs to the intermediate filament family


    NES for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEST_HUMAN, P48681
    Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate
    filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other
    cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and
    mitogen-stimulated proliferation of neural progenitor cells (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
    GO:0019215intermediate filament binding ISS--
         
    NES for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NES:
     Lamellipodia cells 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nes):
     behavior/neurological  cellular  embryogenesis  growth/size  mortality/aging 
     nervous system 

    NES for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NES: Nestm1Dopa Nestm1Nagy

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NES 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NES 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NES 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NES
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NES
    SwitchGear 3'UTR luciferase reporter plasmidNES 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NES

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NES
    Sirion Biotech Customized adenovirus for overexpression of NES

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NES (see all 7)
    OriGene ORF clones in mouse, rat for NES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NES
    Search LifeMap BioReagents cell lines for NES
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NES About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NES
        Cytoskeleton remodeling Neurofilaments


    1 GeneGo (Thomson Reuters) Pathway for NES
        Cytoskeleton remodeling Neurofilaments



    NES for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for NES (P486813 ENSP000003572064) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5Q005353, ENSP000002975184I2D: score=2 STRING: ENSP00000297518
    CDK5R1Q150783, ENSP000003184864I2D: score=2 STRING: ENSP00000318486
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    CDK1P064933I2D: score=1 
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA19384922
    GO:0007399nervous system development ----
    GO:0007417central nervous system development NAS9917366
    GO:0007420brain development ISS--
    GO:0030844positive regulation of intermediate filament depolymerization ISS--

    NES for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NES for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NES (NEST)

    10/27 Novoseek inferred chemical compound relationships for NES gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tanabin 83.1 5 17854500 (3), 10636467 (1), 9361289 (1)
    bromodeoxyuridine 62.1 38 16902995 (3), 10686078 (1), 18693285 (1), 15269271 (1) (see all 15)
    retinoic acid 55.2 18 8522959 (1), 15530878 (1), 17335085 (1), 16195347 (1) (see all 14)
    gaba 35.1 10 12724646 (3), 19223540 (1), 20479529 (1), 15473979 (1) (see all 5)
    vegf 30.6 16 19473053 (3), 17611402 (2), 12781997 (1), 17027979 (1) (see all 10)
    2-mercaptoethanol 30.2 2 17046576 (1), 16336835 (1)
    c-peptide 29.8 2 15602695 (2)
    temozolomide 21.9 1 18817556 (1)
    matrigel 21.8 2 10571412 (1), 16495796 (1)
    glutamate 18.4 3 18629509 (1), 12786777 (1), 20452788 (1)

    Search CenterWatch for drugs/clinical trials and news about NES / NEST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NES gene: 
    NM_006617.1  

    Unigene Cluster for NES:

    Nestin
    Hs.527971  [show with all ESTs]
    Unigene Representative Sequence: NM_006617
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368223(uc001fpq.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NES
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NES
    SwitchGear 3'UTR luciferase reporter plasmidNES 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NES
    Clone
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    OriGene clones in human, mouse for NES (see all 7)
    OriGene ORF clones in mouse, rat for NES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NES
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NES
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NES
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NES

    Additional mRNA sequence: 

    AB073350.1 AF086454.1 AK025494.1 BC032580.1 BC051373.1 BC108285.1 BC142611.1 

    6 DOTS entries:

    DT.446554  DT.121422934  DT.95304497  DT.100752302  DT.95159044  DT.91681816 

    24/49 AceView cDNA sequences (see all 49):

    AA953545 BC051373 BQ638119 BX119194 NM_006617 BX645147 BM451320 BI816812 
    BU554136 AI253123 BU856484 BG912782 T28212 BX479858 AW168445 BF509846 
    AL133969 BU931678 AI934601 BG180147 BU931101 AL120767 BC032580 BF340882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NES expression in normal human tissues (normalized intensities)      NES embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGACTCC
    NES Expression
    About this image


    NES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 29 entries
             Meningeal Cells Anterior Meninges
             Cerebral Cortex
             Neural stem cell line (CTX0E03)
             bFGF induced cells ( Generation of motor and gamma-aminobutyric acid (GABA) neurons...
             Human Hippocampal Astrocytes   
             nerve/cranial/hypoglossal XII   
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Fetal spinal cord stem cells (NSI-566)
             Ventral Horn   
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 5 entries
             Muscle Satellite Cells Lumbar Muscle Satellite Pool
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             Neural rosettes ( Motor neuron differentiation using noggin induction )

    See NES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NES

    SOURCE GeneReport for Unigene cluster: Hs.527971

    UniProtKB/Swiss-Prot: NEST_HUMAN, P48681
    Tissue specificity: CNS stem cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including NES: 
              Notch Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NES gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nes1 , 5 nestin1, 5 61.72(n)1
    49.9(a)1
      3 (38.78 cM)5
    180081  NM_016701.31  NP_057910.31 
     879710785 
    chicken
    (Gallus gallus)
    Aves NES1 nestin 47.08(n)
    33.11(a)
      395890  NM_205033.1  NP_990364.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia M99387.12   -- 77.59(n)    M99387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nes1 nestin 40.04(n)
    24.78(a)
      100150939  XM_001919887.3  XP_001919922.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ifc-26
    ifb-26
    (see all 10)
    Intermediate filament protein ifb-2
    (see all 10)
    6(a)
    15(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    X(642161-654903)
    II(5750188-5754141)


    ENSEMBL Gene Tree for NES (if available)
    TreeFam Gene Tree for NES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NES gene
    SYNM2  
    1 SIMAP similar gene for NES using alignment to 5 protein entries:     NEST_HUMAN (see all proteins):
    DES

    NES for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/324 SNPs in NES are shown (see all 324)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678342121,2
    C--128005374(+) GGATA-/AC/ACAC/
    ACACACACAC
    CACAC
    1 -- us2k10--------
    rs112645141,2
    C,F,A,H--128006775(+) CCTCCC/TAAAGT 1 -- us2k17Minor allele frequency- T:0.39NA WA 18
    rs355221041,2
    C--156638211(+) TAATG-/GGGGGG 1 -- ds50010--------
    rs589486701,2
    C--156647776(+) CACAC-/ACACAC
    ACACACAC
    GCACA
    1 -- us2k11Minor allele frequency- ACACACACACACAC:0.00NA 2
    rs1880061871,2
    --163136752(+) ACCCTA/GCTCCC 1 -- ds50010--------
    rs1174545521,2
    F--163136769(+) TCAGGC/TTGAGG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1928414571,2
    --163136848(+) CTAATG/TGGGGG 1 -- ds50010--------
    rs1844278801,2
    --163136903(+) TCAGTA/TCTGTG 1 -- ds50010--------
    rs75121901,2
    C,F--163137004(+) AGGCCC/TCAGCA 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs115856201,2
    C,H--163137072(+) GGAGGC/TAGCCC 1 -- ds50014Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for NES (156638555 - 156647189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NES:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872473CNV Loss21882294
    nsv523181CNV Loss19592680


    Human Gene Mutation Database (HGMD): NES
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NES
    DNA2.0 Custom Variant and Variant Library Synthesis for NES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600915    OMIM disorders: --

    20/102 diseases for NES (see all 102):    About MalaCards
    oligoastrocytoma    anaplastic ganglioglioma    anaplastic oligoastrocytoma    papillary glioneuronal tumor
    medulloepithelioma    brain ischemia    brain glioma    pituitary infarct
    central neurocytoma    subependymal giant cell astrocytoma    subependymoma    periventricular leukomalacia
    central nervous system germ cell tumor    leukomalacia    optic nerve glioma    dysembryoplastic neuroepithelial tumor
    malignant peripheral nerve sheath tumor    ganglioglioma    vascular malformations    anaplastic astrocytoma

    7 diseases from the University of Copenhagen DISEASES database for NES:
    Malignant glioma     Brain cancer     Cerebrovascular accident     Medulloblastoma
    Teratoma     Parkinson's disease     Embryonal carcinoma

    NES for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/71 Novoseek inferred disease relationships for NES gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain stem tumors 71.2 3 16480595 (1), 20368050 (1), 18092184 (1)
    glioblastoma 68.6 23 16529857 (2), 16457706 (2), 19082452 (2), 10640425 (1) (see all 15)
    glioma 68.1 40 17537489 (3), 17611402 (2), 18282166 (2), 17873113 (2) (see all 29)
    neuroepithelial tumors 66 5 1538585 (2), 16529857 (1), 17611402 (1), 18998057 (1)
    brain tumors 52.6 9 17537489 (1), 1538585 (1), 17456355 (1), 15805284 (1) (see all 8)
    carcinoma embryonal 51.3 4 17234757 (1), 19221495 (1), 18092184 (1)
    glioblastoma multiforme 49.8 6 16457706 (2), 17127461 (1), 19087689 (1), 9850047 (1)
    tumors 48.4 180 20429619 (6), 18925963 (6), 1382841 (5), 20425043 (5) (see all 79)
    cns tumors 48.1 12 1382841 (4), 11799134 (3), 17537489 (1), 8947955 (1) (see all 6)
    teratoma 45.9 2 15127288 (1), 18611917 (1)

    Genetic Association Database (GAD): NES
    Human Genome Epidemiology (HuGE) Navigator: NES (1 document)

    Export disorders for NES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NES gene, integrated from 9 sources (see all 666):
    (articles sorted by number of sources associating them with NES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PubMed id 1478958)1, 2, 3 Dahlstrand J.... Lendahl U. (1992)
    2. Variants in the nestin gene and coronary heart disease. (PubMed id 18724036)1, 4 Meng W....McKeown P.P. (2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. (PubMed id 9917366)1, 2 Yaworsky P.J. and Kappen C. (1999)
    5. An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells. (PubMed id 9104587)1, 3 Lothian C. and Lendahl U. (1997)
    6. Expression of nestin in rat and human glomerular podocytes. (PubMed id 17784648)1, 9 Ishizaki M....Fukuda Y. (2006)
    7. Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)1, 9 Sahlgren C.M....Eriksson J.E. (2003)
    8. Expression of nestin in the podocytes of normal and diseased human kidneys. (PubMed id 17255215)1, 9 Su W....Hao C.M. (2007)
    9. A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. (PubMed id 17036052)1, 9 Sahlgren C.M....Eriksson J.E. (2006)
    10. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. (PubMed id 11278541)1, 9 Sahlgren C.M....Eriksson J.E. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10763 HGNC: 7756 AceView: NES Ensembl:ENSG00000132688 euGenes: HUgn10763
    ECgene: NES H-InvDB: NES

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NES Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NES gene:
    Search GeneIP for patents involving NES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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