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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NES Gene

protein-coding GIFtS: 54
GCID: GC01M156639

nestin

Explore 104 diseases affiliated with
NES via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nestin¹
FLJ21841¹

External Ids:	HGNC: 7756¹	Entrez Gene: 10763²	Ensembl: ENSG00000132688⁷	OMIM: 600915⁵	UniProtKB: P48681³

Export aliases for NES gene to outside databases

Previous GC identifers: GC00U990485 GC01M153416 GC01M153855 GC01M153451 GC01M154905 GC01M127996

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NES:

This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.

(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681

Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate

filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other

cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and

mitogen-stimulated proliferation of neural progenitor cells (By similarity)

Gene Wiki entry for NES (Nestin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NES gene promoter:
AhR Bach1 RP58 Pax-5 Olf-1 Tal-1beta Ik-3 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NES promoter sequence

Search SABiosciences Chromatin IP Primers for NES

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NES

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q23

NES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NES gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M156639: view genomic region (about GC identifiers)

Start:	156,638,555 bp from pter	End:	156,647,189 bp from pter
Size:	8,635 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681 (See protein sequence)

Recommended Name: Nestin

Size: 1621 amino acids; 177439 Da

Subunit: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as

vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate

filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity)

Developmental stage: Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments

Secondary accessions: O00552 Q3LIF5 Q5SYZ6

Explore the universe of human proteins at neXtProt for NES: NX_P48681

Post-translational modifications:

Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is

reorganized (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P48681

NES Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006608.1

ENSEMBL proteins:

ENSP00000357206

Human Recombinant Protein Products for NES:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for NES
	GenScript Custom Purified and Recombinant Proteins Services for NES
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NES

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IDA	19384922
GO:0005882	intermediate filament	NAS	9917366
GO:0045111	intermediate filament cytoskeleton	IDA	--

NES for ontologies About GeneDecksing

NES Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NES
	R&D Systems Antibodies for NES (Nestin)
	OriGene Antibodies (see all 4): NES OriGene Custom Antibody Services for NES
	GenScript Superior Antibodies for NES
	Novus Biologicals NES Antibodies
	Abcam antibodies for NES
	Uscn Antibodies for NES
	ThermoFisher Antibody for NES

Assay Products for NES:

	EMD Millipore Kits and Assays for the Analysis of NES
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NES
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NES

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NES for domains About GeneDecksing

3 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR016044 F

Graphical View of Domain Structure for InterPro Entry P48681

ProtoNet protein and cluster: P48681

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NEST_HUMAN, P48681

Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate

filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other

cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and

mitogen-stimulated proliferation of neural progenitor cells (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005198	structural molecule activity	IEA	--
GO:0019215	intermediate filament binding	ISS	--
GO:0031730	CCR5 chemokine receptor binding	--	--

NES for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NES:

Lamellipodia cells

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nes):

behavior/neurological	cellular	embryogenesis	growth/size	mortality/aging
nervous system

NES for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NES: Nes^tm1Dopa Nes^tm1Nagy

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NES

miRNA Products:		OriGene 3'-UTR Clone: NES Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NES
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NES
		SwitchGear 3'UTR luciferase reporter plasmid: NES 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NES (see all 7) OriGene shRNA RFP: NES OriGene siRNA: NES
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NES
		Sirion Biotech Custom design and validation of potent shRNA sequences against NES

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NES
			Sirion Biotech Customized adenovirus for overexpression of NES Sirion Biotech Customized adenovirus for potent knockdown of NES

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NES (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NES OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NES
		Search LifeMap BioReagents cell lines for NES
		Sirion Biotech Customized stable knockdown cell line services for NES Sirion Biotech Customized inducible knockdown cell line services for NES

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Neurofilaments

Cytoskeleton remodeling Neurofilaments

1.00

Cytoskeleton remodeling_Neurofilaments

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NES

Cytoskeleton remodeling Neurofilaments

1 GeneGo (Thomson Reuters) Pathway for NES

Cytoskeleton remodeling Neurofilaments

NES for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NES

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for NES (P48681³ ENSP00000357206⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK5	Q00535³, ENSP00000297518⁴	I2D: score=2 STRING: ENSP00000297518
CDK5R1	Q15078³, ENSP00000318486⁴	I2D: score=2 STRING: ENSP00000318486
SRRM1	Q8IYB3³, ENSP00000326261⁴	I2D: score=1 STRING: ENSP00000326261
CDK1	P06493³	I2D: score=1
SIRT7	ENSP00000329466⁴	STRING: ENSP00000329466

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IDA	19384922
GO:0007399	nervous system development	--	--
GO:0007417	central nervous system development	NAS	9917366
GO:0007420	brain development	ISS	--
GO:0010212	response to ionizing radiation	--	--

NES for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NES for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NES
10/27 Novoseek chemical compound relationships for NES gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tanabin	83.1	5	17854500 (3), 10636467 (1), 9361289 (1)
bromodeoxyuridine	62.1	38	16902995 (3), 10686078 (1), 18693285 (1), 15269271 (1) (see all 15)
retinoic acid	55.2	18	8522959 (1), 15530878 (1), 17335085 (1), 16195347 (1) (see all 14)
gaba	35.1	10	12724646 (3), 19223540 (1), 20479529 (1), 15473979 (1) (see all 5)
vegf	30.6	16	19473053 (3), 17611402 (2), 12781997 (1), 17027979 (1) (see all 10)
2-mercaptoethanol	30.2	2	17046576 (1), 16336835 (1)
c-peptide	29.8	2	15602695 (2)
temozolomide	21.9	1	18817556 (1)
matrigel	21.8	2	10571412 (1), 16495796 (1)
glutamate	18.4	3	18629509 (1), 12786777 (1), 20452788 (1)

Search CenterWatch for drugs/clinical trials and news about NES / NEST

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NES gene:

NM_006617.1

Unigene Cluster for NES:

Nestin

Hs.527971 [show with all ESTs]

Unigene Representative Sequence: NM_006617

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000368223(uc001fpq.3)

miRNA Products:		OriGene 3'-UTR Clone: NES Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NES
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NES
		SwitchGear 3'UTR luciferase reporter plasmid: NES 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NES (see all 7) OriGene shRNA RFP: NES OriGene siRNA: NES
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NES
		Sirion Biotech Custom design and validation of potent shRNA sequences against NES

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NES (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NES OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NES (NM_006617)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NES
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NES

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NES Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NES
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NES
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NES

Additional cDNA sequence:

AB073350.1 AF086454.1 AK025494.1 BC032580.1 BC051373.1 BC108285.1 BC142611.1

6 DOTS entries:

DT.446554 DT.121422934 DT.95304497 DT.100752302 DT.95159044 DT.91681816

24/49 AceView cDNA sequences (see all 49):

BX645147 BX119194 BQ638119 AA953545 BC051373 NM_006617 AI934601 BF340882

BG180147 BF509846 BQ953465 BU931678 AL133969 T28212 BX353453 AW168445

AU252483 BI816812 BG912782 BC032580 BU554136 BU931101 BM451320 BU856484

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NES expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGACTCC

About this image

NES expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Anterior Meninges

Mature Meningeal Cells

Meninges

Meninges

Kidney

Lateral Plate Mesoderm

Splanchnic Mesoderm

Pericytes

Limb

Forelimb Muscle Satellite Pool

Forelimb Muscle Satellite Cells

Skeletal Muscle

Limb

Hindlimb Muscle Satellite Pool

Hindlimb Muscle Satellite Cells

Skeletal Muscle

Liver

Sinusoids

Hepatic Stellate Cells

Liver

Skeletal Muscle

Cervical Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Lumbar Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Sacral Muscle Satellite Pool

Muscle Satellite Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/20 LifeMap Cells (see all 20)

Name

Category

Fetal spinal cord stem cells (NSI-566) (Fetal Stem / Progenitor Cell)

Spinal Cord

Neural stem cells (Fetal Stem / Progenitor Cell)

Spinal Cord

Neural stem cells (Fetal Stem / Progenitor Cell)

Spinal Cord

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Floating neuronal aggregates (Generation of choroi...)

Otx2+Corin+ cells (Derivation of functi...)

Midbrain neural progenitor-like cells (Differentiation of h...)

N2/LSB/S/F8-induced cells (Generation of midbra...)

See NES Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NES

SOURCE GeneReport for Unigene cluster: Hs.527971

UniProtKB/Swiss-Prot: NEST_HUMAN, P48681

Tissue specificity: CNS stem cells

SABiosciences Expression via Pathway-Focused PCR Arrays including NES:

Notch Signaling Targets in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NES Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NES
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NES
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NES

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NES

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NES gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	NES¹	nestin	47.08(n) 33.11(a)	395890 NM_205033.1 NP_990364.1
African clawed frog (Xenopus laevis)	Amphibia	M99387.1²	--	77.59(n)	M99387.1
zebrafish (Danio rerio)	Actinopterygii	nes¹	nestin	40.04(n) 24.78(a)	100150939 XM_001919887.3 XP_001919922.1

ENSEMBL Gene Tree for NES (if available)
TreeFam Gene Tree for NES (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NES gene

LMNB1² SYNM² VIM² INA² LMNA² PRPH² DES² NEFM²

LMNB2² NEFH² GFAP²

1 SIMAP similar gene for NES using alignment to 5 protein entries: NEST_HUMAN (see all proteins):

DES

NES for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7512190^1,2	C	--	127995967(+)	`AGGCCC/TCAGCA`	1	--	ds500¹		1		NA	2
rs11585620^1,2	C,H	--	127996035(+)	`GGAGGC/TAGCCC`	1	--	ds500¹		4		NS EA	418
rs16837589^1,2	C,F,H	--	127996177(+)	`CTTTAT/CTCAGG`	1	--	ut3¹ ese³		9		NA NS WA	1052
rs6683168^1,2	C,H	--	127996447(+)	`CTATCG/AGGATT`	1	--	ut3¹ ese³		4		NS EA	420
rs3088202^1,2	H	--	127996504(+)	`CAGGGT/GGGGAG`	1	--	ut3¹ ese³		5		MN NS EA	602
rs115856653^1,2	C,F	--	127996659(+)	`GAGGCG/ATCCTT`	1	--	ut3¹		1		WA	118
rs28539337^1,2	C	--	127996798(+)	`CAGGAG/TCCCCT`	2	D A	mis¹ ese³		1		NA	4548
rs77577879^1,2	C	--	128000057(+)	`TGTTTC/TTTTCT`	2	K E	mis¹		0	--	--	--	--
rs12564229^1,2	C,F,H	--	128000528(+)	`GCTCAG/TGACTG`	2	M L	mis¹ ese³		8		NS EA NA	602
rs28429500^1,2	C	--	128000913(+)	`CCAGGA/GGGGTC`	2	P L	mis¹ ese³		0	--	--	--	--

HapMap Linkage Disequilibrium report for NES (156638555 - 156647189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NES: --
Human Gene Mutation Database (HGMD): NES

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NES

DNA2.0 Custom Variant and Variant Library Synthesis for NES

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NES for disorders           About GeneDecksing

OMIM gene information: 600915    OMIM disorders: --

20/104 diseases for NES (see all 104):    About MalaCards

dandy-walker malformation malignant peripheral nerve sheath tumor central nervous system germ cell tumor subependymal giant cell astrocytoma

dysembryoplastic neuroepithelial tumor gastrointestinal stromal tumor periventricular leukomalacia amyotrophic lateral sclerosis

becker muscular dystrophy dermatofibrosarcoma protuberans leukomalacia optic nerve glioma

pilocytic astrocytoma anaplastic oligoastrocytoma central neurocytoma oligoastrocytoma

primitive neuroectodermal tumor soft tissue sarcoma cerebral artery occlusion neuroectodermal tumors

7 diseases from the University of Copenhagen DISEASES database for NES:

Malignant glioma Cerebrovascular accident Brain cancer Medulloblastoma

Teratoma Parkinson's disease Embryonal carcinoma

10/71 Novoseek disease relationships for NES gene (see all 71) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
brain stem tumors	71.2	3	16480595 (1), 20368050 (1), 18092184 (1)
glioblastoma	68.6	23	16529857 (2), 16457706 (2), 19082452 (2), 10640425 (1) (see all 15)
glioma	68.1	40	17537489 (3), 17611402 (2), 18282166 (2), 17873113 (2) (see all 29)
neuroepithelial tumors	66	5	1538585 (2), 16529857 (1), 17611402 (1), 18998057 (1)
brain tumors	52.6	9	17537489 (1), 1538585 (1), 17456355 (1), 15805284 (1) (see all 8)
carcinoma embryonal	51.3	4	17234757 (1), 19221495 (1), 18092184 (1)
glioblastoma multiforme	49.8	6	16457706 (2), 17127461 (1), 19087689 (1), 9850047 (1)
tumors	48.4	180	20429619 (6), 18925963 (6), 1382841 (5), 20425043 (5) (see all 79)
cns tumors	48.1	12	1382841 (4), 11799134 (3), 17537489 (1), 8947955 (1) (see all 6)
teratoma	45.9	2	15127288 (1), 18611917 (1)

Human Genome Epidemiology (HuGE) Navigator: NES (1 document)

Export disorders for NES gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NES gene, integrated from 9 sources (see all 656):
(articles sorted by number of sources associating them with NES)

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Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PubMed id 1478958)^{1, 2, 3} Dahlstrand J.... Lendahl U. (1992)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. (PubMed id 9917366)^{1, 2} Yaworsky P.J. and Kappen C. (1999)
An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells. (PubMed id 9104587)^{1, 3} Lothian C. and Lendahl U. (1997)
Expression of nestin in rat and human glomerular podocytes. (PubMed id 17784648)^{1, 9} Ishizaki M....Fukuda Y. (2006)
Cdk5 regulates the organization of Nestin and its association with p35. (PubMed id 12832492)^{1, 9} Sahlgren C.M....Eriksson J.E. (2003)
Expression of nestin in the podocytes of normal and diseased human kidneys. (PubMed id 17255215)^{1, 9} Su W....Hao C.M. (2007)
A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. (PubMed id 17036052)^{1, 9} Sahlgren C.M....Eriksson J.E. (2006)
Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. (PubMed id 11278541)^{1, 9} Sahlgren C.M....Eriksson J.E. (2001)
Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. (PubMed id 18925963)^{1, 9} Veselska R....Sterba J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10763	HGNC: 7756	AceView: NES	Ensembl:ENSG00000132688	euGenes: HUgn10763
ECgene: NES	H-InvDB: NES

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NES	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NES gene
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Patent Information for NES gene:
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