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Aliases for NES Gene

Aliases for NES Gene

  • Nestin 2 3
  • Nbla00170 3

External Ids for NES Gene

Previous GeneCards Identifiers for NES Gene

  • GC00U990485
  • GC01M153416
  • GC01M153855
  • GC01M153451
  • GC01M154905
  • GC01M156639
  • GC01M127996

Summaries for NES Gene

Entrez Gene Summary for NES Gene

  • This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

GeneCards Summary for NES Gene

NES (Nestin) is a Protein Coding gene. Diseases associated with NES include brain ischemia and medulloepithelioma. Among its related pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is SYNM.

UniProtKB/Swiss-Prot for NES Gene

  • Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Wiki entry for NES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NES Gene

Genomics for NES Gene

Regulatory Elements for NES Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NES Gene

Start:
156,668,763 bp from pter
End:
156,677,397 bp from pter
Size:
8,635 bases
Orientation:
Minus strand

Genomic View for NES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NES Gene

Proteins for NES Gene

  • Protein details for NES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48681-NEST_HUMAN
    Recommended name:
    Nestin
    Protein Accession:
    P48681
    Secondary Accessions:
    • O00552
    • Q3LIF5
    • Q5SYZ6

    Protein attributes for NES Gene

    Size:
    1621 amino acids
    Molecular mass:
    177439 Da
    Quaternary structure:
    • Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity).

neXtProt entry for NES Gene

Proteomics data for NES Gene at MOPED

Post-translational modifications for NES Gene

  • Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NES Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NES Gene

Domains for NES Gene

Gene Families for NES Gene

HGNC:
  • IFF4 :Intermediate filaments type IV

Protein Domains for NES Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NES Gene

Graphical View of Domain Structure for InterPro Entry

P48681

UniProtKB/Swiss-Prot:

NEST_HUMAN :
  • P48681
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with NES: view

Function for NES Gene

Molecular function for NES Gene

UniProtKB/Swiss-Prot Function: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity).

Gene Ontology (GO) - Molecular Function for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0019215 intermediate filament binding ISS --
genes like me logo Genes that share ontologies with NES: view
genes like me logo Genes that share phenotypes with NES: view

Animal Models for NES Gene

MGI Knock Outs for NES:

Animal Model Products

miRNA for NES Gene

miRTarBase miRNAs that target NES

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NES

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NES Gene

Localization for NES Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NES Gene COMPARTMENTS Subcellular localization image for NES gene
Compartment Confidence
cytoskeleton 5
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 19384922
GO:0005882 intermediate filament NAS 9917366
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with NES: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NES Gene

Pathways for NES Gene

genes like me logo Genes that share pathways with NES: view

Pathways by source for NES Gene

1 GeneGo (Thomson Reuters) pathway for NES Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for NES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0007399 nervous system development --
GO:0007417 central nervous system development NAS 9917366
GO:0007420 brain development ISS --
GO:0030844 positive regulation of intermediate filament depolymerization ISS --
genes like me logo Genes that share ontologies with NES: view

Compounds for NES Gene

(27) Novoseek inferred chemical compound relationships for NES Gene

Compound -log(P) Hits PubMed IDs
tanabin 83.1 5
bromodeoxyuridine 62.1 17
retinoic acid 55.2 14
gaba 35.1 7
vegf 30.6 13
genes like me logo Genes that share compounds with NES: view

Transcripts for NES Gene

mRNA/cDNA for NES Gene

(49) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NES Gene

Nestin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NES

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NES
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NES Gene

No ASD Table

Relevant External Links for NES Gene

GeneLoc Exon Structure for
NES
ECgene alternative splicing isoforms for
NES

Expression for NES Gene

mRNA expression in normal human tissues for NES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NES Gene

This gene is overexpressed in Heart - Atrial Appendage (6.0) and Heart - Left Ventricle (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NES Gene

SOURCE GeneReport for Unigene cluster for NES Gene Hs.527971

mRNA Expression by UniProt/SwissProt for NES Gene

P48681-NEST_HUMAN
Tissue specificity: CNS stem cells
genes like me logo Genes that share expressions with NES: view

In Situ Assay Products

Orthologs for NES Gene

This gene was present in the common ancestor of chordates.

Orthologs for NES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NES 35
  • 99.06 (n)
  • 98.01 (a)
NES 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NES 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NES 35
  • 79.21 (n)
  • 68.39 (a)
NES 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nes 16
Nes 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NES 36
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NES 36
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nes 36
  • 17 (a)
OneToOne
Species with no ortholog for NES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NES Gene

ENSEMBL:
Gene Tree for NES (if available)
TreeFam:
Gene Tree for NES (if available)

Paralogs for NES Gene

Paralogs for NES Gene

Selected SIMAP similar genes for NES Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NES: view

Variants for NES Gene

Sequence variations from dbSNP and Humsavar for NES Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs951781 - 156,671,745(-) AGAGC(A/G)TAGAG missense, reference
rs1046650 -- 156,669,208(-) ACATA(C/T)GGTTT utr-variant-3-prime
rs1046694 -- 156,668,880(-) GCCGT(C/T)TGGCC utr-variant-3-prime
rs2075529 -- 156,674,874(-) TGCCC(C/G)CACCC intron-variant
rs2282442 -- 156,672,871(-) GCCAG(C/T)GTCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NES Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv872473 CNV Loss 21882294

Relevant External Links for NES Gene

HapMap Linkage Disequilibrium report
NES
Human Gene Mutation Database (HGMD)
NES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NES Gene

Disorders for NES Gene

(71) Novoseek inferred disease relationships for NES Gene

Disease -log(P) Hits PubMed IDs
brain stem tumors 71.2 3
glioblastoma 68.6 18
glioma 68.1 37
neuroepithelial tumors 66 5
brain tumors 52.6 8

Relevant External Links for NES

Genetic Association Database (GAD)
NES
Human Genome Epidemiology (HuGE) Navigator
NES
genes like me logo Genes that share disorders with NES: view

No data available for UniProtKB/Swiss-Prot for NES Gene

Publications for NES Gene

  1. Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. (PMID: 1478958) Dahlstrand J. … Lendahl U. (J. Cell Sci. 1992) 2 3 4
  2. Heterogeneous expression of nestin in myofibroblasts of various human tissues. (PMID: 20518888) Kishaba Y. … Niki T. (Pathol. Int. 2010) 3 23
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. (PMID: 18799194) Kawamoto M. … Tajiri T. (Hum. Pathol. 2009) 3 23
  5. Diagnostic utility of nestin expression in pediatric tumors in the region of the kidney. (PMID: 19417621) Murphy A.J. … Thorner P.S. (Appl. Immunohistochem. Mol. Morphol. 2009) 3 23

Products for NES Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NES
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NES
    • Block miRNA regulation of NES using miScript Target Protectors

    Sources for NES Gene

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