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Aliases for NEPRO Gene

Aliases for NEPRO Gene

  • Nucleolus And Neural Progenitor Protein 2 3 5
  • C3orf17 3 4
  • Chromosome 3 Open Reading Frame 17 2
  • Protein Nepro Homolog 3
  • NET17 3

External Ids for NEPRO Gene

Previous HGNC Symbols for NEPRO Gene

  • C3orf17

Summaries for NEPRO Gene

GeneCards Summary for NEPRO Gene

NEPRO (Nucleolus And Neural Progenitor Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NEPRO Gene

  • May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.

Additional gene information for NEPRO Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEPRO Gene

Genomics for NEPRO Gene

Regulatory Elements for NEPRO Gene

Enhancers for NEPRO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H112634 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +380.3 380267 10.2 PKNOX1 ZNF133 SIN3A ZNF2 ZNF143 FOS RUNX3 DEK GTF2B REST SPICE1 NEPRO CD200R1 ENSG00000242770 C3orf52 MIR567 CCDC80 SLC35A5 LINC01279
GH03H113742 1.4 ENCODE dbSUPER 17.5 -726.4 -726435 8.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 NEPRO SPICE1 LOC101180897 CFAP44 BOC QTRT2 USF3 ATP6V1A NAA50 ENSG00000239280
GH03H112559 1.1 ENCODE 17.5 +458.3 458257 4.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SLC35A5 NEPRO SPICE1 LOC101180897 CFAP44 BOC CCDC80 MIR567 C3orf52 ENSG00000279349
GH03H112670 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +347.3 347348 4.6 KLF1 CEBPB FEZF1 ZNF384 NR3C1 EP300 NFIC JUND POLR2A ZNF585B NEPRO CFAP44 CCDC80 SLC35A5 GC03M112647 GC03P112695
GH03H112615 1 ENCODE dbSUPER 17.5 +404.0 404026 1.1 BACH1 ZNF175 PYGO2 ZNF644 RELA IRF9 DIDO1 NFE2 ZNF639 RFX1 NEPRO SPICE1 LOC101180897 CFAP44 BOC CCDC80 LINC01279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEPRO on UCSC Golden Path with GeneCards custom track

Promoters for NEPRO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156651 561 1801 HDGF FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5

Genomic Locations for NEPRO Gene

Genomic Locations for NEPRO Gene
chr3:113,002,440-113,019,861
(GRCh38/hg38)
Size:
17,422 bases
Orientation:
Minus strand
chr3:112,721,287-112,738,708
(GRCh37/hg19)

Genomic View for NEPRO Gene

Genes around NEPRO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEPRO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEPRO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEPRO Gene

Proteins for NEPRO Gene

  • Protein details for NEPRO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NW34-NEPRO_HUMAN
    Recommended name:
    Nucleolus and neural progenitor protein
    Protein Accession:
    Q6NW34
    Secondary Accessions:
    • D3DN69
    • Q68DM6
    • Q9H7U0
    • Q9UFM4

    Protein attributes for NEPRO Gene

    Size:
    567 amino acids
    Molecular mass:
    64552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB55998.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEPRO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEPRO Gene

Post-translational modifications for NEPRO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEPRO Gene

Domains & Families for NEPRO Gene

Gene Families for NEPRO Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NEPRO Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6NW34

UniProtKB/Swiss-Prot:

NEPRO_HUMAN :
  • Belongs to the nepro family.
Family:
  • Belongs to the nepro family.
genes like me logo Genes that share domains with NEPRO: view

No data available for Suggested Antigen Peptide Sequences for NEPRO Gene

Function for NEPRO Gene

Molecular function for NEPRO Gene

UniProtKB/Swiss-Prot Function:
May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.

Phenotypes From GWAS Catalog for NEPRO Gene

genes like me logo Genes that share phenotypes with NEPRO: view

Animal Models for NEPRO Gene

MGI Knock Outs for NEPRO:

Clone Products

  • Addgene plasmids for NEPRO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEPRO Gene

Localization for NEPRO Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEPRO Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEPRO gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with NEPRO: view

Pathways & Interactions for NEPRO Gene

SuperPathways for NEPRO Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEPRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0045665 negative regulation of neuron differentiation ISS --
GO:0045747 positive regulation of Notch signaling pathway ISS --
genes like me logo Genes that share ontologies with NEPRO: view

No data available for Pathways by source and SIGNOR curated interactions for NEPRO Gene

Drugs & Compounds for NEPRO Gene

No Compound Related Data Available

Transcripts for NEPRO Gene

Clone Products

  • Addgene plasmids for NEPRO

Alternative Splicing Database (ASD) splice patterns (SP) for NEPRO Gene

No ASD Table

Relevant External Links for NEPRO Gene

GeneLoc Exon Structure for
NEPRO
ECgene alternative splicing isoforms for
NEPRO

Expression for NEPRO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NEPRO Gene:

NEPRO

Evidence on tissue expression from TISSUES for NEPRO Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NEPRO: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEPRO Gene

Orthologs for NEPRO Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEPRO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf17 33 34
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia C1H3orf17 33
  • 86.83 (n)
C3orf17 34
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C33H3orf17 33
  • 86.73 (n)
C3orf17 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC027231 33 34
  • 76.26 (n)
Nepro 16
rat
(Rattus norvegicus)
Mammalia RGD1311458 33
  • 75.93 (n)
oppossum
(Monodelphis domestica)
Mammalia C3orf17 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C3orf17 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H3orf17 33
  • 53.93 (n)
C3orf17 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C3orf17 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf17 33
  • 50.8 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-22a1.3 33
  • 47.03 (n)
C9H3orf17 34
  • 30 (a)
OneToOne
Species where no ortholog for NEPRO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEPRO Gene

ENSEMBL:
Gene Tree for NEPRO (if available)
TreeFam:
Gene Tree for NEPRO (if available)

Paralogs for NEPRO Gene

No data available for Paralogs for NEPRO Gene

Variants for NEPRO Gene

Sequence variations from dbSNP and Humsavar for NEPRO Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000021673 -- 113,019,013(+) CTCCT(A/G)AATTA intron-variant
rs1000043513 -- 113,013,333(+) AACCT(G/T)CATCA intron-variant, nc-transcript-variant, reference, missense
rs1000153167 -- 113,006,325(+) CTGTT(C/G)ATAAT intron-variant
rs1000233842 -- 113,013,023(+) AAGTT(C/T)AGTTT intron-variant
rs1000274593 -- 113,006,656(+) ACTGT(C/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEPRO Gene

Variant ID Type Subtype PubMed ID
esv3893763 CNV loss 25118596
nsv591293 CNV loss 21841781

Variation tolerance for NEPRO Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEPRO Gene

Human Gene Mutation Database (HGMD)
NEPRO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEPRO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEPRO Gene

Disorders for NEPRO Gene

Relevant External Links for NEPRO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEPRO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEPRO

No disorders were found for NEPRO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEPRO Gene

Publications for NEPRO Gene

  1. Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch. (PMID: 19906856) Muroyama Y … Saito T (Development (Cambridge, England) 2009) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for NEPRO Gene

  • Addgene plasmids for NEPRO

Sources for NEPRO Gene

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