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NEO1 Gene

protein-coding   GIFtS: 65
GCID: GC15P073346

Neogenin 1

(Previous name: neogenin (chicken) homolog 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neogenin 11 2     Immunoglobulin Superfamily1
NGN2 3 5     Member 21
Immunoglobulin Superfamily DCC Subclass Member 22 3     Neogenin (Chicken) Homolog 11
IGDCC22 3     neogenin2
DCC Subclass1     Neogenin Homolog 12

External Ids:    HGNC: 77541   Entrez Gene: 47562   Ensembl: ENSG000000671417   OMIM: 6019075   UniProtKB: Q928593   

Export aliases for NEO1 gene to outside databases

Previous GC identifers: GC15P069350 GC15P066449 GC15P070920 GC15P071060 GC15P071131 GC15P050240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEO1 Gene:
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein
consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain
and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein
may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated
with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Feb 2010)

GeneCards Summary for NEO1 Gene:
NEO1 (neogenin 1) is a protein-coding gene. GO annotations related to this gene include receptor activity and cadherin binding. An important paralog of this gene is CHL1.

UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859
Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to
their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and
adult tissues

Gene Wiki entry for NEO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEO1 gene promoter:
         LHX3b/Lhx3b   POU3F2   AREB6   SRY   HOXA5   LHX3a/Lhx3a   Chx10   Pax-4a   RSRFC4   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEO1 promoter sequence
   Search Chromatin IP Primers for NEO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.3-q23   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q22.3-q23

NEO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEO1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P073346:  view genomic region     (about GC identifiers)

Start:
73,344,051 bp from pter      End:
73,597,547 bp from pter
Size:
253,497 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859 (See protein sequence)
Recommended Name: Neogenin precursor  
Size: 1461 amino acids; 160017 Da
Subunit: Interacts with RGMA. Interacts with MYO10 (By similarity)
Selected PDB 3D structures from and Proteopedia for NEO1 (see all 7):
1X5F (3D)        1X5G (3D)        1X5H (3D)        1X5I (3D)        1X5J (3D)        1X5K (3D)    
Secondary accessions: B7ZKM9 B7ZKN0 O00340 Q17RX1
Alternative splicing: 4 isoforms:  Q92859-1   Q92859-2   Q92859-3   Q92859-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEO1: NX_Q92859

Explore proteomics data for NEO1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn73, Asn210, Asn326, Asn470, Asn489, Asn639, Asn715, Asn909
  • Modification sites at PhosphoSitePlus

  • See NEO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166094.1  NP_001166095.1  NP_002490.2  

    ENSEMBL proteins: 
     ENSP00000341198   ENSP00000453317   ENSP00000453200   ENSP00000454024   ENSP00000261908  
    Reactome Protein details: Q92859

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR010560 Neogenin_C
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q92859

    ProtoNet protein and cluster: Q92859

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003962 Fibronectin type III repeat signature
    IPB010560 Neogenin


    UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859
    Similarity: Belongs to the immunoglobulin superfamily. DCC family
    Similarity: Contains 6 fibronectin type-III domains
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with NEO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEO1_HUMAN, Q92859
    Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to
    their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and
    adult tissues

         Genatlas biochemistry entry for NEO1:
    neogenin,cell surface protein,DCC related member of the Ig superfamily,expressed in nervous system of embryo

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0045296cadherin binding IEA--
         
    Find genes that share ontologies with NEO1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NEO1:
     Decreased viability of wild-ty  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Neo1):
     endocrine/exocrine gland  integument  mortality/aging  nervous system 

    Find genes that share phenotypes with NEO1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NEO1

    miRNA
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    miRTarBase miRNAs that target NEO1:
    hsa-mir-590-3p (MIRT016178), hsa-mir-32-5p (MIRT028322), hsa-mir-183-5p (MIRT047083), hsa-mir-320a (MIRT044583), hsa-mir-484 (MIRT041971)

    Block miRNA regulation of human, mouse, rat NEO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEO1 (see all 88):
    hsa-miR-3607-3p hsa-miR-128 hsa-miR-374a hsa-miR-342-3p hsa-miR-3142 hsa-miR-4274 hsa-miR-3116 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidNEO1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEO1_HUMAN, Q92859: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus2
    nucleus2
    chloroplast1
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9169140
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NEO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEO1 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    3Netrin-1 signaling
    Netrin-1 signaling
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with NEO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for NEO1
        Netrin-1 signaling
    CDO in myogenesis


    1 Kegg Pathway  (Kegg details for NEO1):
        Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEO1
    Interactions:

        Search GeneGlobe Interaction Network for NEO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEO1 (Q928593 ENSP000002619084) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PITPNAQ001693, ENSP000003168094I2D: score=2 STRING: ENSP00000316809
    NTN1O956313, ENSP000001732294I2D: score=1 STRING: ENSP00000173229
    NTN3O006343, ENSP000002939734I2D: score=1 STRING: ENSP00000293973
    PTK2Q053973, ENSP000003411894I2D: score=5 STRING: ENSP00000341189
    CASP3P425743I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance TAS--
    GO:0007520myoblast fusion IEA--
    GO:0042692muscle cell differentiation TAS--

    Find genes that share ontologies with NEO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEO1 gene (3 alternative transcripts): 
    NM_001172623.1  NM_001172624.1  NM_002499.3  

    Unigene Cluster for NEO1:

    Neogenin 1
    Hs.388613  [show with all ESTs]
    Unigene Representative Sequence: NM_002499
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339362 ENST00000560262 ENST00000558964 ENST00000558485 ENST00000560328
    ENST00000560352 ENST00000560407 ENST00000558807 ENST00000560808 ENST00000558886
    ENST00000261908(uc002avm.4 uc010ukx.2 uc010uky.2 uc002avn.4 uc010ukz.2)

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    Selected qRT-PCR Assays for microRNAs that regulate NEO1 (see all 88):
    hsa-miR-3607-3p hsa-miR-128 hsa-miR-374a hsa-miR-342-3p hsa-miR-3142 hsa-miR-4274 hsa-miR-3116 hsa-miR-200b
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      QuantiFast Probe-based Assays in human, mouse, rat NEO1

    Additional mRNA sequence: 

    AB209412.1 AL355708.1 AL359597.1 AL390182.1 BC117161.1 BC143270.1 BC143271.1 BC143279.1 
    U61262.1 U72391.1 

    9 DOTS entries:

    DT.217276  DT.75122843  DT.100752161  DT.121019971  DT.121019984  DT.121019999  DT.40118194  DT.95125422 
    DT.40120627 

    Selected AceView cDNA sequences (see all 284):

    Z42210 H30080 CK822684 AI049995 AA366349 BE674155 AI126934 AI762231 
    AI052128 AI339096 AI631010 BE328727 AW675155 AL042932 CA843071 BE464675 
    AW604109 AI888097 BM717246 AI381819 AW672987 AU132592 AW026094 CB068937 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NEO1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                  -                                                                                                         
    SP2:                                                                                                              -                             -               

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for NEO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEO1 Expression
    About this image


    NEO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Lung (Respiratory System)
             Trachea
     
     Kidney (Urinary System)
             Metanephros
    NEO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388613

    UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859
    Tissue specificity: Widely expressed and also in cancer cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEO1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neo11 , 5 neogenin1, 5 90.74(n)1
    94.52(a)1
      9 (31.81 cM)5
    180071  NM_008684.21  NP_032710.21 
     588746795 
    chicken
    (Gallus gallus)
    Aves NEO11 neogenin 1 79.73(n)
    87.69(a)
      395822  XM_004943656.1  XP_004943713.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEO16
    neogenin 1
    84(a)
    1 ↔ 1
    GL343517.1(148939-221279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.162672 Transcribed sequence with moderate similarity to protein more 75.77(n)    142000183 
    zebrafish
    (Danio rerio)
    Actinopterygii neo12 neogenin 1 75.27(n)   266983  AY029280.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fra1 , 3 motor axon guidance netrin receptor3
    frazzled1
    38(a)3
    47.08(n)1
    38.89(a)1
      363771  NM_165913.11  NP_725185.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-403 membrane protein 32(a)   I(5680370-5691444)   --


    ENSEMBL Gene Tree for NEO1 (if available)
    TreeFam Gene Tree for NEO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEO1 gene
    CHL12  ROBO12  CNTN52  CNTN42  IGDCC42  NRCAM2  L1CAM2  ROBO22  
    CNTN22  CNTN62  NFASC2  CNTN32  DCC2  PRTG2  IGDCC32  ROBO32  
    CNTN12  
    3 SIMAP similar genes for NEO1 using alignment to 2 protein entries:     NEO1_HUMAN (see all proteins):
    DCC    MUSK    L1CAM

    Find genes that share paralogs with NEO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEO1 (see all 4736)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429866431,2
    C--50187140(+) CCTTT-/TTTG  
            
    TTTGT
    3 -- int10--------
    rs3765225831,2
    C--50191748(+) CCCCC-/CCCG  
            
    CCTTT
    3 -- int10--------
    rs678577551,2
    C--50191750(+) CCCCC-/CCCCC 
     CG
    /CCCG
    CTTTT
    3 -- int10--------
    rs561611171,2
    C--50191854(+) GTGCC-/A/AC  
     AGCCTCC
    CAATA
    6 -- int1 cds10--------
    rs559977081,2
    C--50191855(+) TGCCC-/A/ACAGCCTCCC/AG
    CCTCCCA
    /CAGCCTCCCA
    AATAG
    6 -- int1 cds10--------
    rs350319121,2
    C--50192474(+) GGGGCT/-TTTTT 3 -- int12Minor allele frequency- -:0.25NA 4
    rs1998344251,2
    C--50192474(+) GGGGC-/TTTTTTT 3 -- int10--------
    rs720006551,2
    C--50192641(+) TTTTGTATTT   
      TTTT
    /-
    TTTTT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1495887241,2
    C--50195454(+) TTAAT-/TTTG  
            
    TTTGT
    3 -- int10--------
    rs1509322621,2
    C--50205660(+) ATTAC-/TTAC  
            
    AGGCA
    3 -- int10--------

    HapMap Linkage Disequilibrium report for NEO1 (73344051 - 73594051 bp, first 250kb of NEO1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NEO1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672004CNV Deletion23128226
    esv2061446CNV Deletion18987734
    esv2749870CNV Deletion23290073
    esv2749869CNV Deletion23290073
    nsv94493CNV Insertion16902084
    nsv904338CNV Loss21882294
    nsv525462CNV Loss19592680
    dgv2402n71CNV Loss21882294
    dgv2403n71CNV Loss21882294
    nsv517966CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEO1
    DNA2.0 Custom Variant and Variant Library Synthesis for NEO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601907    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NEO1:
    Colorectal cancer

    Find genes that share disorders with NEO1           About GenesLikeMe

    Genetic Association Database (GAD): NEO1
    Human Genome Epidemiology (HuGE) Navigator: NEO1 (2 documents)

    Export disorders for NEO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEO1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with NEO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of neogenin, a DCC-related gene. (PubMed id 9121761)1, 2, 3, 9 Meyerhardt J.A.... Fearon E.R. (Oncogene 1997)
    2. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3- q23. (PubMed id 9169140)1, 2, 9 Vielmetter J.... Dreyer W.J. (Genomics 1997)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. (PubMed id 23775842)1 Milla L.A....Palma V. (Int. J. Cancer 2014)
    6. Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub. (PubMed id 23744777)1 Bell C.H....Siebold C. (Science 2013)
    7. Identification and localization of netrin-4 and neogenin in human first trimester and term placenta. (PubMed id 22705235)1 Dakouane-Giudicelli M....de Mazancourt P. (Placenta 2012)
    8. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage. (PubMed id 22893705)1 Enns C.A....Zhang A.S. (J. Biol. Chem. 2012)
    9. Down-regulation of neogenin accelerated glioma progression through promoter Methylation and its overexpression in SHG-44 Induced Apoptosis. (PubMed id 22666451)1 Wu X....Zhao G. (PLoS ONE 2012)
    10. Identification of the neogenin-binding site on the repulsive guidance molecule A. (PubMed id 22396795)1 Itokazu T....Yamashita T. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4756 HGNC: 7754 AceView: NEO1 Ensembl:ENSG00000067141 euGenes: HUgn4756
    ECgene: NEO1 Kegg: 4756 H-InvDB: NEO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEO1 gene:
    Search GeneIP for patents involving NEO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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