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Aliases for NEO1 Gene

Aliases for NEO1 Gene

  • Neogenin 1 2 3 5
  • Immunoglobulin Superfamily DCC Subclass Member 2 3 4
  • IGDCC2 3 4
  • NGN 3 4
  • Neogenin (Chicken) Homolog 1 2
  • Immunoglobulin Superfamily 2
  • Neogenin Homolog 1 3
  • DCC Subclass 2
  • Member 2 2
  • NTN1R2 3

External Ids for NEO1 Gene

Previous GeneCards Identifiers for NEO1 Gene

  • GC15P069350
  • GC15P066449
  • GC15P070920
  • GC15P071060
  • GC15P071131
  • GC15P073346
  • GC15P050240

Summaries for NEO1 Gene

Entrez Gene Summary for NEO1 Gene

  • This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for NEO1 Gene

NEO1 (Neogenin 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor activity and cadherin binding. An important paralog of this gene is IGDCC3.

UniProtKB/Swiss-Prot for NEO1 Gene

  • Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

Gene Wiki entry for NEO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEO1 Gene

Genomics for NEO1 Gene

Regulatory Elements for NEO1 Gene

Enhancers for NEO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEO1 on UCSC Golden Path with GeneCards custom track

Promoters for NEO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEO1 Gene

Chromosome:
15
Start:
73,051,710 bp from pter
End:
73,305,206 bp from pter
Size:
253,497 bases
Orientation:
Plus strand

Genomic View for NEO1 Gene

Genes around NEO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEO1 Gene

Proteins for NEO1 Gene

  • Protein details for NEO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92859-NEO1_HUMAN
    Recommended name:
    Neogenin
    Protein Accession:
    Q92859
    Secondary Accessions:
    • B7ZKM9
    • B7ZKN0
    • O00340
    • Q17RX1

    Protein attributes for NEO1 Gene

    Size:
    1461 amino acids
    Molecular mass:
    160017 Da
    Quaternary structure:
    • Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.
    Miscellaneous:
    • Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.

    Three dimensional structures from OCA and Proteopedia for NEO1 Gene

    Alternative splice isoforms for NEO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEO1 Gene

Proteomics data for NEO1 Gene at MOPED

Post-translational modifications for NEO1 Gene

  • Glycosylation at Asn 73, Asn 210, Asn 326, Asn 470, Asn 489, Asn 639, Asn 715, and Asn 909
  • Modification sites at PhosphoSitePlus

Other Protein References for NEO1 Gene

Antibody Products

No data available for DME Specific Peptides for NEO1 Gene

Domains & Families for NEO1 Gene

Suggested Antigen Peptide Sequences for NEO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92859

UniProtKB/Swiss-Prot:

NEO1_HUMAN :
  • The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
  • Contains 6 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with NEO1: view

Function for NEO1 Gene

Molecular function for NEO1 Gene

GENATLAS Biochemistry:
neogenin,cell surface protein,DCC related member of the Ig superfamily,expressed in nervous system of embryo
UniProtKB/Swiss-Prot Function:
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
genes like me logo Genes that share phenotypes with NEO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NEO1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEO1 Gene

Localization for NEO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEO1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEO1 Gene COMPARTMENTS Subcellular localization image for NEO1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
extracellular 2
chloroplast 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0098797 plasma membrane protein complex IDA 18335997
genes like me logo Genes that share ontologies with NEO1: view

Pathways & Interactions for NEO1 Gene

genes like me logo Genes that share pathways with NEO1: view

Pathways by source for NEO1 Gene

Gene Ontology (GO) - Biological Process for NEO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA,TAS --
GO:0051149 positive regulation of muscle cell differentiation TAS --
genes like me logo Genes that share ontologies with NEO1: view

No data available for SIGNOR curated interactions for NEO1 Gene

Drugs & Compounds for NEO1 Gene

No Compound Related Data Available

Transcripts for NEO1 Gene

Unigene Clusters for NEO1 Gene

Neogenin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:

Relevant External Links for NEO1 Gene

GeneLoc Exon Structure for
NEO1
ECgene alternative splicing isoforms for
NEO1

Expression for NEO1 Gene

mRNA expression in normal human tissues for NEO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEO1 Gene

This gene is overexpressed in Serum (23.3), Lavage (10.7), Cerebrospinal fluid (7.0), and Fetal Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEO1 Gene



SOURCE GeneReport for Unigene cluster for NEO1 Gene Hs.388613

mRNA Expression by UniProt/SwissProt for NEO1 Gene

Q92859-NEO1_HUMAN
Tissue specificity: Widely expressed and also in cancer cell lines.
genes like me logo Genes that share expression patterns with NEO1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for NEO1 Gene

Orthologs for NEO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEO1 35
  • 93.11 (n)
  • 96.1 (a)
NEO1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEO1 35
  • 93.27 (n)
  • 96.17 (a)
NEO1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neo1 35
  • 90.74 (n)
  • 94.52 (a)
Neo1 16
Neo1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEO1 35
  • 99.61 (n)
  • 99.73 (a)
NEO1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neo1 35
  • 90.5 (n)
  • 94.78 (a)
oppossum
(Monodelphis domestica)
Mammalia NEO1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEO1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEO1 35
  • 79.73 (n)
  • 87.69 (a)
NEO1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEO1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16267 35
zebrafish
(Danio rerio)
Actinopterygii neo1 35
  • 68.01 (n)
  • 71.28 (a)
neo1 36
  • 71 (a)
OneToMany
NEO1 (2 of 2) 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fra 37
  • 38 (a)
fra 35
  • 47.08 (n)
  • 38.89 (a)
fra 36
  • 32 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006083 35
  • 46.44 (n)
  • 39.82 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-40 37
  • 32 (a)
unc-40 36
  • 29 (a)
OneToMany
Species with no ortholog for NEO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEO1 Gene

ENSEMBL:
Gene Tree for NEO1 (if available)
TreeFam:
Gene Tree for NEO1 (if available)

Paralogs for NEO1 Gene

Paralogs for NEO1 Gene

(3) SIMAP similar genes for NEO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEO1: view

Variants for NEO1 Gene

Sequence variations from dbSNP and Humsavar for NEO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4467039 - 73,244,493(+) ACAAC(C/T)TGAGG reference, missense
rs1029 -- 73,180,708(-) ATCCA(A/T)ATATT intron-variant
rs7547 -- 73,305,043(-) GCAGT(A/G)CGGCG utr-variant-3-prime
rs5813703 -- 73,113,478(+) CCAAA(-/G)GAACC intron-variant
rs5813705 -- 73,150,707(+) CAAAT(-/A)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEO1 Gene

Variant ID Type Subtype PubMed ID
nsv904338 CNV Loss 21882294
nsv517966 CNV Gain 19592680
nsv525462 CNV Loss 19592680
dgv2402n71 CNV Loss 21882294
dgv2403n71 CNV Loss 21882294
nsv904343 CNV Gain 21882294
nsv527236 CNV Gain 19592680
esv2749869 CNV Deletion 23290073
esv2061446 CNV Deletion 18987734
esv2672004 CNV Deletion 23128226
esv2749870 CNV Deletion 23290073
nsv94493 CNV Insertion 16902084

Variation tolerance for NEO1 Gene

Residual Variation Intolerance Score: 1.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEO1 Gene

Human Gene Mutation Database (HGMD)
NEO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEO1 Gene

Disorders for NEO1 Gene

Relevant External Links for NEO1

Genetic Association Database (GAD)
NEO1
Human Genome Epidemiology (HuGE) Navigator
NEO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEO1

No disorders were found for NEO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEO1 Gene

Publications for NEO1 Gene

  1. Identification and characterization of neogenin, a DCC-related gene. (PMID: 9121761) Meyerhardt J.A. … Fearon E.R. (Oncogene 1997) 2 3 4 23 67
  2. Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3- q23. (PMID: 9169140) Vielmetter J. … Dreyer W.J. (Genomics 1997) 3 23
  3. Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. (PMID: 25909166) Lv B. … Liu J. (Oncotarget 2015) 3
  4. Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein. (PMID: 25938661) Healey E.G. … Siebold C. (Nat. Struct. Mol. Biol. 2015) 3
  5. Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells. (PMID: 25998984) Zhang Q. … Yue J. (Oncol. Rep. 2015) 3

Products for NEO1 Gene

Sources for NEO1 Gene

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