Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NEO1 Gene

protein-coding GIFtS: 62
GCID: GC15P073346

neogenin 1

(Previous name: neogenin (chicken) homolog 1 )

Explore 7 diseases affiliated with
NEO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neogenin 1¹ ²		HsT17534¹
NGN¹ ² ³ ⁵		Neogenin (Chicken) Homolog 1¹
IGDCC2¹ ² ³		Neogenin¹
Immunoglobulin Superfamily DCC Subclass Member 2² ³		Neogenin Homolog 1²

External Ids:	HGNC: 7754¹	Entrez Gene: 4756²	Ensembl: ENSG00000067141⁷	OMIM: 601907⁵	UniProtKB: Q92859³

Export aliases for NEO1 gene to outside databases

Previous GC identifers: GC15P069350 GC15P066449 GC15P070920 GC15P071060 GC15P071131 GC15P050240

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEO1:

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein

consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and

a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be

involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell

proliferation in certain cancers. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Feb

2010)

UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859

Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their

differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues

Gene Wiki entry for NEO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEO1 gene promoter:
LHX3b/Lhx3b POU3F2 AREB6 SRY HOXA5 LHX3a/Lhx3a Chx10 Pax-4a RSRFC4 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEO1 promoter sequence

Search SABiosciences Chromatin IP Primers for NEO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.3-q23 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q22.3-q23

NEO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEO1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P073346: view genomic region (about GC identifiers)

Start:	73,344,051 bp from pter	End:	73,597,547 bp from pter
Size:	253,497 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859 (See protein sequence)

Recommended Name: Neogenin precursor

Size: 1461 amino acids; 160017 Da

Subunit: Interacts with RGMA. Interacts with MYO10 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein

6/7 PDB 3D structures from and Proteopedia for NEO1 (see all 7):

1X5F (3D)

1X5G (3D)

1X5H (3D)

1X5I (3D)

1X5J (3D)

1X5K (3D)

Secondary accessions: B7ZKM9 O00340 Q17RX1

Alternative splicing: 3 isoforms: Q92859-1 Q92859-2 Q92859-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEO1: NX_Q92859

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92859

NEO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001166094.1 NP_001166095.1 NP_002490.2

ENSEMBL proteins:

ENSP00000341198 ENSP00000453317 ENSP00000453200 ENSP00000454024 ENSP00000261908

Reactome Protein details: Q92859
Human Recombinant Protein Products for NEO1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for NEO1
	OriGene Purified Protein: NEO1 OriGene Protein Over-expression Lysate: NEO1 OriGene Custom Protein Services for NEO1
	GenScript Custom Purified and Recombinant Proteins Services for NEO1
	Novus Biologicals NEO1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NEO1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9169140
GO:0016021	integral to membrane	--	--

NEO1 for ontologies About GeneDecksing

NEO1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for NEO1 (Neogenin)
	Browse OriGene Antibodies OriGene Custom Antibody Services for NEO1
	GenScript Custom Superior Antibodies Services for NEO1
	Novus Biologicals NEO1 Antibodies
	Abcam antibodies for NEO1
	Uscn Antibodies for NEO1
	Search ThermoFisher Antibodies for NEO1

Assay Products for NEO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEO1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR010560 Neogenin_C

IPR003599 Ig_sub

IPR003961 Fibronectin_type3

Graphical View of Domain Structure for InterPro Entry Q92859

ProtoNet protein and cluster: Q92859

3 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

IPB010560 Neogenin

UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859

Similarity: Belongs to the immunoglobulin superfamily. DCC family

Similarity: Contains 6 fibronectin type-III domains

Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NEO1_HUMAN, Q92859

Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their

differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues

Genatlas biochemistry entry for NEO1:

neogenin,cell surface protein,DCC related member of the Ig superfamily,expressed in nervous system of embryo

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0045296	cadherin binding	IEA	--

NEO1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for NEO1:

Decreased viability of wild-ty

Increased G1 DNA content

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Neo1):

endocrine/exocrine gland

integument

mortality/aging

nervous system

NEO1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NEO1

miRNA Products:		OriGene 3'-UTR Clone: NEO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEO1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate NEO1 (see all 88):
		hsa-miR-3607-3p hsa-miR-128 hsa-miR-374a hsa-miR-342-3p hsa-miR-3142 hsa-miR-4274 hsa-miR-3116 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: NEO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEO1 (see all 4) OriGene shRNA RFP: NEO1 OriGene siRNA: NEO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEO1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NEO1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NEO1
			Sirion Biotech Customized adenovirus for overexpression of NEO1 Sirion Biotech Customized adenovirus for potent knockdown of NEO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NEO1 (NM_002499)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEO1
		Search LifeMap BioReagents cell lines for NEO1
		Sirion Biotech Customized stable knockdown cell line services for NEO1 Sirion Biotech Customized inducible knockdown cell line services for NEO1 Sirion Biotech Customized stable overexpressing cell line services for NEO1 Sirion Biotech Customized inducible overexpressing cell line services for NEO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEO1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axon guidance

Axon guidance

1.00

Developmental Biology

0.69

Activation of p38 alpha/beta MAPK

CDO in myogenesis

0.55

Myogenesis

0.55

Netrin-1 signaling

Netrin-1 signaling

1.00

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

Netrin-1 signaling

Netrin-1 signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for NEO1 (see all 6)

	Developmental Biology
	Netrin-1 signaling
	Myogenesis
	CDO in myogenesis
	Netrin-1 signaling

1 Kegg Pathway (Kegg details for NEO1):

Cell adhesion molecules (CAMs)

NEO1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NEO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/17 Interacting proteins for NEO1 (Q92859³ ENSP00000261908⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PITPNA	Q00169³, ENSP00000316809⁴	I2D: score=2 STRING: ENSP00000316809
NTN1	O95631³, ENSP00000173229⁴	I2D: score=1 STRING: ENSP00000173229
NTN3	O00634³, ENSP00000293973⁴	I2D: score=1 STRING: ENSP00000293973
PTK2	Q05397³, ENSP00000341189⁴	I2D: score=5 STRING: ENSP00000341189
CASP3	P42574³	I2D: score=2

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0007520	myoblast fusion	IEA	--
GO:0042692	muscle cell differentiation	TAS	--

NEO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NEO1
Search CenterWatch for drugs/clinical trials and news about NEO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NEO1 gene (3 alternative transcripts):

NM_001172623.1 NM_001172624.1 NM_002499.3

Unigene Cluster for NEO1:

Neogenin 1

Hs.388613 [show with all ESTs]

Unigene Representative Sequence: NM_002499

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000339362 ENST00000560262 ENST00000558964 ENST00000558485 ENST00000560328

ENST00000560352 ENST00000560407 ENST00000558807 ENST00000560808 ENST00000558886

ENST00000261908(uc002avm.4 uc010ukx.2 uc010uky.2 uc002avn.4 uc010ukz.2)

miRNA Products:		OriGene 3'-UTR Clone: NEO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEO1
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate NEO1 (see all 88):
		hsa-miR-3607-3p hsa-miR-128 hsa-miR-374a hsa-miR-342-3p hsa-miR-3142 hsa-miR-4274 hsa-miR-3116 hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: NEO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEO1 (see all 4) OriGene shRNA RFP: NEO1 OriGene siRNA: NEO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEO1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NEO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NEO1 (NM_002499)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NEO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEO1

Additional cDNA sequence:

AB209412.1 AL355708.1 AL359597.1 AL390182.1 BC117161.1 BC143270.1 BC143271.1 BC143279.1

U61262.1 U72391.1

9 DOTS entries:

DT.217276 DT.75122843 DT.100752161 DT.121019971 DT.121019984 DT.121019999 DT.40118194 DT.95125422

DT.40120627

24/284 AceView cDNA sequences (see all 284):

CB154583 AI739564 CA843823 AA954219 AI524293 BQ917623 CD722663 AL390182

BF437670 AI588871 Z42748 BU160358 CB070379 AA363681 AI393298 AI689764

AI097595 U72391 AA335289 BQ575097 BE856703 BU146322 BQ000467 AW117483

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NEO1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:																	-
SP2:																																					-										-

ExUns:	24	^	25	^	26	^	27	^	28	^	29
SP1:
SP2:

ECgene alternative splicing isoforms for NEO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NEO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NEO1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NEO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEO1

SOURCE GeneReport for Unigene cluster: Hs.388613

UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859

Tissue specificity: Widely expressed and also in cancer cell lines

SABiosciences Custom PCR Arrays for NEO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NEO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NEO1 gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Neo1^{1 , 5}	neogenin^{1, 5}	90.74(n)¹ 94.52(a)¹		9 (31.81 cM)⁵ 18007¹ NM_008684.2¹ NP_032710.2¹ 58874679⁵
chicken (Gallus gallus)	Aves	NEO1¹	neogenin 1	79.73(n) 87.61(a)		395822 XM_413704.3 XP_413704.3
lizard (Anolis carolinensis)	Reptilia	NEO1⁶	--	86(a)	1 ↔ 1	GL343517.1(179455-217137)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.16267²	Transcribed sequence with moderate similarity to protein more	75.77(n)		142000183
zebrafish (Danio rerio)	Actinopterygii	neo1²	neogenin 1	75.27(n)		266983 AY029280.1
fruit fly (Drosophila melanogaster)	Insecta	fra³	motor axon guidance netrin receptor	38(a)		--
worm (Caenorhabditis elegans)	Secernentea	unc-40³	membrane protein	32(a)		I(5680370-5691444) --

ENSEMBL Gene Tree for NEO1 (if available)
TreeFam Gene Tree for NEO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NEO1 gene

CDON² ROBO2² ROBO1² ROBO4² IGDCC4² BOC² DCC² PRTG²

IGDCC3² ROBO3²

4 SIMAP similar genes for NEO1 using alignment to 3 protein entries: NEO1_HUMAN (see all proteins):

DCC MUSK PRTG L1CAM

NEO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8030182^1,2	A,H	--	50173884(+)	`TTAACC/TTGATA`	3	--	us2k¹		4		NS EA	416
rs8031803^1,2	C,A	--	50174100(+)	`CAATTC/TACAGT`	3	--	us2k¹		0	--	--	--	--
rs55969660^1,2	C,F	--	50174362(+)	`ACTAGC/GATGAG`	3	--	us2k¹		6		WA CSA NA	246
rs62016792^1,2	C	--	50174471(+)	`GCTTTA/GGAATA`	3	--	us2k¹		3		NA	124
rs76988332^1,2	F	--	50176889(+)	`GGGGTG/ATCAGA`	3	--	int¹		1		NA	120
rs78310642^1,2	F	--	50177863(+)	`TTTATT/GACTTA`	3	--	int¹		1		WA	118
rs11856466^1,2	C,F,H	--	50179359(+)	`ATCAAG/AAAGAC`	3	--	int¹		25		NS EA NA WA CSA	2404
rs28450594^1,2		--	50180182(+)	`CCCCCC/TCTGCC`	3	--	int¹		0	--	--	--	--
rs79777409^1,2		--	50181536(+)	`TGTGTA/TTGGTT`	3	--	int¹		0	--	--	--	--
rs57453823^1,2	C,F	--	50181897(+)	`AAGAGT/CTGGCA`	3	--	int¹		6		WA CSA NA	245

HapMap Linkage Disequilibrium report for NEO1 (73344051 - 73594051 bp, first 250kb of NEO1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NEO1
3 Indels: 45365 87740 77001

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEO1

DNA2.0 Custom Variant and Variant Library Synthesis for NEO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEO1 for disorders           About GeneDecksing

OMIM gene information: 601907    OMIM disorders: --

7 diseases for NEO1:    About MalaCards

hepatitis b colon cancer colorectal cancer breast cancer

hepatitis neuronitis iron overload

1 disease from the University of Copenhagen DISEASES database for NEO1:

Colorectal cancer

Human Genome Epidemiology (HuGE) Navigator: NEO1 (2 documents)

Export disorders for NEO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NEO1 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with NEO1)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of neogenin, a DCC-related gene. (PubMed id 9121761)^{1, 2, 3, 9} Meyerhardt J.A.... Fearon E.R. (1997)
Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3- q23. (PubMed id 9169140)^{1, 2, 9} Vielmetter J.... Dreyer W.J. (1997)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and localization of netrin-4 and neogen in in human first trimester and term placenta. (PubMed id 22705235)¹ Dakouane-Giudicelli M....de Mazancourt P. (2012)
Neogenin interacts with matriptase-2 to facilitate hem ojuvelin cleavage. (PubMed id 22893705)¹ Enns C.A....Zhang A.S. (2012)
Down-regulation of neogenin accelerated glioma progres sion through promoter Methylation and its overexpression in SHG-44 Induced Apopt osis. (PubMed id 22666451)¹ Wu X....Zhao G. (2012)
Identification of the neogenin-binding site on the rep ulsive guidance molecule A. (PubMed id 22396795)¹ Itokazu T....Yamashita T. (2012)
Crystal structure of a hemojuvelin-binding fragment o f neogenin at 1.8A8. (PubMed id 20971194)¹ Yang F....Bjorkman P.J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4756	HGNC: 7754	AceView: NEO1	Ensembl:ENSG00000067141	euGenes: HUgn4756
ECgene: NEO1	Kegg: 4756	H-InvDB: NEO1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NEO1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NEO1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NEO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NEO1 gene:
Search GeneIP for patents involving NEO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for NEO1 (Neogenin)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for NEO1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEO1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEO1
	OriGene Protein Over-expression Lysate for NEO1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NEO1		OriGene 3'-UTR Clone for NEO1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEO1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for NEO1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NEO1		OriGene Custom Protein Services for NEO1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEO1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEO1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEO1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEO1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEO1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEO1

	GenScript Custom Purified and Recombinant Proteins Services for NEO1		GenScript cDNA clones with any tag delivered in your preferred vector for NEO1
	GenScript Custom Assay Services for NEO1		GenScript Custom Superior Antibodies Services for NEO1
	GenScript Custom overexpressing Cell Line Services for NEO1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NEO1 promoter
	Search Chromatin IP Primers for NEO1
	RT² qPCR Primer Assay in human, mouse, rat NEO1
	Search GNC Networks for NEO1
	SABiosciences Custom PCR Arrays for NEO1

Search Tocris compounds for NEO1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for NEO1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NEO1 antibodies
	NEO1 lysates

	Antibodies for NEO1
	See all of Abcam's Antibodies, Kits and Proteins for NEO1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NEO1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NEO1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEO1

	SwitchGear 3'UTR luciferase reporter plasmids for NEO1
	SwitchGear Promoter luciferase reporter plasmids for NEO1

Search ThermoFisher Antibodies for NEO1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEO1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NEO1

Sirion Biotech Customized:

	stable knockdown cell line services for NEO1
	inducible knockdown cell line services for NEO1
	design and validation of potent shRNA sequences against NEO1
	adenovirus for potent knockdown of NEO1
	adenovirus for overexpression of NEO1
	stable overexpressing cell line services for NEO1
	inducible overexpressing cell line services for NEO1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NEO1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

NEO1 Gene

neogenin 1

Aliases
for NEO1 gene

Summaries
for NEO1 gene

Genomic Views
for NEO1 gene

Proteins
for NEO1 gene

Protein Domains /
Families
for NEO1 gene

Function
for NEO1 gene

Pathways & Interactions
for NEO1 gene

Drugs & Compounds
for NEO1 gene

Transcripts
for NEO1 gene

Expression
for NEO1 gene

Orthologs
for NEO1 gene

Paralogs
for NEO1 gene

Genomic Variants
for NEO1 gene

Disorders / Diseases
for NEO1 gene

Publications
for NEO1 gene

External Searches for NEO1 gene

Genome Databases showing NEO1 gene

Other Databases showing NEO1 gene

Specialized Databases showing NEO1 gene

Intellectual Property
for NEO1 gene

Products
for NEO1 gene

View Random Gene

Advanced Search

Export list of displayed genes

NEO1 Gene

neogenin 1

Aliasesfor NEO1 gene

Summariesfor NEO1 gene

Genomic Viewsfor NEO1 gene

Proteinsfor NEO1 gene

Protein Domains /Familiesfor NEO1 gene

Functionfor NEO1 gene

Pathways & Interactionsfor NEO1 gene

Drugs & Compoundsfor NEO1 gene

Transcriptsfor NEO1 gene

Expression for NEO1 gene

Orthologsfor NEO1 gene

Paralogsfor NEO1 gene

Genomic Variantsfor NEO1 gene

Disorders / Diseasesfor NEO1 gene

Publicationsfor NEO1 gene

External Searches for NEO1 gene

Genome Databases showing NEO1 gene

Other Databases showing NEO1 gene

Specialized Databases showing NEO1 gene

Intellectual Propertyfor NEO1 gene

Productsfor NEO1 gene

View Random Gene

Aliases
for NEO1 gene

Summaries
for NEO1 gene

Genomic Views
for NEO1 gene

Proteins
for NEO1 gene

Protein Domains /
Families
for NEO1 gene

Function
for NEO1 gene

Pathways & Interactions
for NEO1 gene

Drugs & Compounds
for NEO1 gene

Transcripts
for NEO1 gene

Expression
for NEO1 gene

Orthologs
for NEO1 gene

Paralogs
for NEO1 gene

Genomic Variants
for NEO1 gene

Disorders / Diseases
for NEO1 gene

Publications
for NEO1 gene

Intellectual Property
for NEO1 gene

Products
for NEO1 gene