Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NENF Gene

protein-coding   GIFtS: 50
GCID: GC01P212606

neudesin neurotrophic factor

(Previous name: neuron derived neurotrophic factor )
 Explore 4 diseases affiliated with
NENF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NENF    

Aliases
for NENF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neudesin Neurotrophic Factor1 2     Neuron Derived Neurotrophic Factor1
CIR21 2 3 5     Cell Growth-Inhibiting Protein 472
SPUF1 2 3     Neudesin1
SCIRP101 2     SCIRP10-Related Protein2
Cell Immortalization-Related Protein 22 3     Spinal Cord Injury Related Protein 102
Neuron-Derived Neurotrophic Factor2 3     SPUF Protein3
Secreted Protein Of Unknown Function2 3     

External Ids:    HGNC: 303841   Entrez Gene: 299372   Ensembl: ENSG000001176917   OMIM: 6118745   UniProtKB: Q9UMX53   
ORGUL members:         
NONCODE:n407178    

Export aliases for NENF gene to outside databases

Previous GC identifers: GC01P208996 GC01P210672 GC01P183282


Summaries
for NENF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NENF:
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of
this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants.
(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal
differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic
activity is enhanced by binding to heme (By similarity)




Genomic Views
for NENF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NENF gene promoter:
         Elk-1   LHX3b/Lhx3b   STAT1   STAT1beta   STAT5A   STAT1alpha   COMP1   LHX3a/Lhx3a   IRF-7A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NENF promoter sequence
   Search SABiosciences Chromatin IP Primers for NENF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NENF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

NENF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NENF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212606:  view genomic region     (about GC identifiers)

Start:
 212,606,229 bp from pter      End:
 212,619,721 bp from pter
Size:
 13,493 bases      Orientation:
 plus strand

Proteins
for NENF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5 (See protein sequence)
Recommended Name: Neudesin precursor  
Size: 172 amino acids; 18856 Da
Subcellular location: Secreted, extracellular space (By similarity)
Secondary accessions: A1KYQ8 Q53FZ6 Q5TM90

Explore the universe of human proteins at neXtProt for NENF: NX_Q9UMX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UMX5

    • NENF Protein expression data from MOPED and PaxDb:    About this image 
    NENF Protein Expression
    REFSEQ proteins: NP_037481.1  
    ENSEMBL proteins: 
     ENSP00000355955  

    Human Recombinant Protein Products for NENF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NENF (Neudesin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NENF
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NENF 
    GenScript Custom Purified and Recombinant Proteins Services for NENF
    Novus Biologicals NENF Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NENF

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    NENF for ontologies           About GeneDecksing



    NENF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NENF
    R&D Systems Antibodies for NENF (Neudesin)
    OriGene Antibodies: NENF
    OriGene Custom Antibody Services for NENF 
    GenScript Custom Superior Antibodies Services for NENF
    Novus Biologicals NENF Antibodies
    Abcam antibodies for NENF 
    Uscn Antibodies for NENF
    ThermoFisher Antibodies for NENF

    Assay Products for NENF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NENF
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NENF

    Protein Domains /
    Families
    for NENF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NENF for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry Q9UMX5

    ProtoNet protein and cluster: Q9UMX5

    1 Blocks protein family: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
    Domain: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His
    residue at position 82 (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    Function
    for NENF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NENF_HUMAN, Q9UMX5
    Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
    primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal
    differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic
    activity is enhanced by binding to heme (By similarity)
    Induction: Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing progesterone
    receptor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    NENF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NENF:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NENF 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NENF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NENF
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmid: NENF 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NENF (see all 7)
    OriGene shRNA RFP: NENF
    OriGene siRNA: NENF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NENF
    Sirion Biotech Custom design and validation of potent shRNA sequences against NENF 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NENF
    Sirion Biotech Customized adenovirus for overexpression of NENF 
    Sirion Biotech Customized adenovirus for potent knockdown of NENF

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NENF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NENF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NENF (NM_013349)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NENF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NENF
    Search LifeMap BioReagents cell lines for NENF
    Sirion Biotech Customized stable knockdown cell line services for NENF 
    Sirion Biotech Customized inducible knockdown cell line services for NENF
    Sirion Biotech Customized stable overexpressing cell line services for NENF
    Sirion Biotech Customized inducible overexpressing cell line services for NENF

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF


    Pathways & Interactions
    for NENF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NENF

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043410positive regulation of MAPK cascade IEA--

    NENF for ontologies           About GeneDecksing



    Drugs & Compounds
    for NENF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NENF

    2 HMDB Compounds for NENF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    Search CenterWatch for drugs/clinical trials and news about NENF 

    Transcripts
    for NENF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NENF gene: 
    NM_013349.4  

    Unigene Cluster for NENF:

    Neudesin neurotrophic factor
    Hs.461787  [show with all ESTs]
    Unigene Representative Sequence: BU502624
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366988(uc001hjd.3 uc010ptf.2) ENST00000479589 ENST00000473900
    ENST00000472389

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NENF
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NENF
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmid: NENF 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NENF (see all 7)
    OriGene shRNA RFP: NENF
    OriGene siRNA: NENF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NENF
    Sirion Biotech Custom design and validation of potent shRNA sequences against NENF 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NENF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NENF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NENF (NM_013349)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NENF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NENF
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NENF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NENF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NENF

    Additional cDNA sequence: 

    AB126219.1 AF000267.1 AF049672.1 AF173937.1 AK074431.1 AK223135.1 AY762102.1 BC008823.2 
    NR_026598.1 

    13 DOTS entries:

    DT.118861  DT.101956271  DT.100036815  DT.92433314  DT.100637912  DT.100861921  DT.121438068  DT.100641834 
    DT.121438145  DT.100647155  DT.92433318  DT.92433319  DT.95222043 

    24/139 AceView cDNA sequences (see all 139):

    BM678055 CA313613 BM725580 AW058078 BM740482 AA775277 BM687084 BE395739 
    AW168702 BF811404 AW025767 BM793409 AA074675 BF589633 AW328250 BF475349 
    AA635889 BG704144 BG220165 CD675711 BM873467 AF049672 BM790844 D31417 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NENF    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                                 
    SP2:                                                      
    SP3:                    -     -                           
    SP4:                                -                     


    ECgene alternative splicing isoforms for NENF

    Expression
    for NENF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NENF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACACTACGGG
    NENF Expression
    About this image

    NENF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See NENF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NENF

    SOURCE GeneReport for Unigene cluster: Hs.461787
        SABiosciences Custom PCR Arrays for NENF
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NENF
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NENF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NENF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NENF
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF

    Orthologs
    for NENF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NENF gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NENF1 neudesin neurotrophic factor 75.42(n)
    76.25(a)    		   421370  XM_419430.2  XP_419430.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NENF6
    		 --
    		 79(a)
    		 1 ↔ 1
    		 1(238523112-238527967)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.67872 Transcribed sequence with weak similarity to protein more 73.42(n)    142017620 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa11a042 wufa11a04 76.98(n)   334967  CF347670.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AtMAPR26
    		 putative steroid-binding protein 3
    		 44(a)
    		 1 ↔ 1
    		 2(10609394-10612232)
    rice
    (Oryza sativa)    		 Liliopsida Os10g05025001 hypothetical protein 53.42(n)
    42.47(a)    		   4349045  NM_001071527.1  NP_001064992.1 


    ENSEMBL Gene Tree for NENF (if available)
    TreeFam Gene Tree for NENF (if available) 

    Paralogs
    for NENF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NENF gene
    PGRMC12  PGRMC22  CYB5D22  
    3 SIMAP similar genes for NENF using alignment to 1 protein entry:     NENF_HUMAN:
    CYB5D2    PGRMC1    PGRMC2

    NENF for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NENF
    PGOHUM00000239908 PGOHUM00000244005 PGOHUM00000235124


    Genomic Variants
    for NENF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 NCBI SNPs in NENF are shown (see all 278)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1459901781,2
    		--212604288(+) GCTTTC/GTGACT 2 -- us2k10--------
    rs1146717131,2
    		--212604381(+) GATGGA/GTCTCT 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1901726551,2
    		--212604390(+) CTGTCC/TCCCTG 2 -- us2k10--------
    rs1399842181,2
    		--212604503(+) CAAACA/CTGCTG 2 -- us2k10--------
    rs1816094531,2
    		--212604637(+) AAATTA/CTCCCT 2 -- us2k10--------
    rs121335821,2
    		C,F,A,H--212604885(+) ACTATG/ACTCTG 2 -- us2k120Minor allele frequency- A:0.20NS EA NA WA CSA 2346
    rs1855899251,2
    		--212604924(+) GTCTAA/CGAACC 2 -- us2k10--------
    rs781867521,2
    		--212604938(+) TCTTGG/TGTCTG 2 -- us2k12Minor allele frequency- T:0.13CSA WA 120
    rs127553831,2
    		C,F--212604966(+) TGTTAA/GTTCCT 2 -- us2k1 tfbs36Minor allele frequency- G:0.11NA WA 246
    rs1115064861,2
    		C--212605221(+) TCAGTG/AAGGCC 2 -- us2k12Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for NENF (212606229 - 212619721 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NENF: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NENF
    DNA2.0 Custom Variant and Variant Library Synthesis for NENF

    Disorders / Diseases
    for NENF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NENF for disorders           About GeneDecksing

    OMIM gene information: 611874    OMIM disorders: --

    4 diseases for NENF:    About MalaCards
    spinal cord injury    estrogen-receptor positive breast cancer    neuronitis    breast cancer


    Export disorders for NENF gene to outside databases

    Publications
    for NENF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NENF gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with NENF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. (PubMed id 15605373)1, 2, 3, 9 Kimura I....Itoh N. (2005)
    2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. (PubMed id 9771976)1, 2, 3 Ma L.... Bacchetti S. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. (PubMed id 18056703)1, 9 Kimura I....Fujimoto M. (2008)
    5. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. (PubMed id 16645950)2, 9 Neubauer H.... Cahill M.A. (2006)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NENF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NENF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29937 HGNC: 30384 AceView: SPUF Ensembl:ENSG00000117691 euGenes: HUgn29937
    ECgene: NENF H-InvDB: NENF

    Other Databases showing NENF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NENF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NENF Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NENF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NENF gene:
    Search GeneIP for patents involving NENF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NENF gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NENF
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NENF (Neudesin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for NENF (Neudesin)  
     OriGene Antibodies for NENF   OriGene shRNA RFP for NENF  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NENF   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NENF  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NENF   OriGene 3'-UTR Clone for NENF  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NENF   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NENF  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NENF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NENF   OriGene Custom Protein Services for NENF  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NENF
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NENF
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NENF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NENF
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NENF
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NENF
     GenScript Custom Purified and Recombinant Proteins Services for NENF GenScript cDNA clones with any tag delivered in your preferred vector for NENF
     GenScript Custom Assay Services for NENF GenScript Custom Superior Antibodies Services for NENF
     GenScript Custom overexpressing Cell Line Services for NENF CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NENF promoter
     Search Chromatin IP Primers for NENF
     Search RT2 qPCR Primer Assays in human, mouse, rat NENF
     Search GNC Networks for NENF
     SABiosciences Custom PCR Arrays for NENF
     Search Tocris compounds for NENF
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NENF antibodies
     NENF proteins
     Antibodies for NENF
     See all of Abcam's Antibodies, Kits and Proteins for NENF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NENF Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NENF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF
     SwitchGear 3'UTR luciferase reporter plasmids for NENF
     SwitchGear Promoter luciferase reporter plasmids for NENF
     ThermoFisher Antibodies for NENF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NENF
    Sirion Biotech Customized:
     stable knockdown cell line services for NENF
     inducible knockdown cell line services for NENF
     design and validation of potent shRNA sequences against NENF
     adenovirus for potent knockdown of NENF
     adenovirus for overexpression of NENF
     stable overexpressing cell line services for NENF
     inducible overexpressing cell line services for NENF
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NENF gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4