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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NENF Gene

protein-coding   GIFtS: 52
GCID: GC01P212606

Neudesin Neurotrophic Factor

(Previous name: neuron derived neurotrophic factor)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neudesin Neurotrophic Factor1 2     Neuron Derived Neurotrophic Factor1
CIR22 3 5     SCIRP102
neudesin1 2     Cell Growth-Inhibiting Protein 472
Cell Immortalization-Related Protein 22 3     SCIRP10-Related Protein2
Neuron-Derived Neurotrophic Factor2 3     Spinal Cord Injury Related Protein 102
Secreted Protein Of Unknown Function2 3     SPUF Protein3
SPUF2 3     

External Ids:    HGNC: 303841   Entrez Gene: 299372   Ensembl: ENSG000001176917   OMIM: 6118745   UniProtKB: Q9UMX53   
ORGUL members:         
NONCODE14:n407178      

Export aliases for NENF gene to outside databases

Previous GC identifers: GC01P208996 GC01P210672 GC01P183282


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NENF Gene:
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A
pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript
variants. (provided by RefSeq, Jan 2009)

GeneCards Summary for NENF Gene: 
NENF (neudesin neurotrophic factor) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NENF include spinal cord injury, and estrogen-receptor positive breast cancer. GO annotations related to this gene include growth factor activity and heme binding. An important paralog of this gene is CYB5D2.

UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on
neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells.
Neurotrophic activity is enhanced by binding to heme (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NENF gene promoter:
         Elk-1   LHX3b/Lhx3b   STAT1   STAT1beta   STAT5A   STAT1alpha   COMP1   LHX3a/Lhx3a   IRF-7A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNENF promoter sequence
   Search SABiosciences Chromatin IP Primers for NENF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NENF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

NENF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NENF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212606:  view genomic region     (about GC identifiers)

Start:
212,606,229 bp from pter      End:
212,619,721 bp from pter
Size:
13,493 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5 (See protein sequence)
Recommended Name: Neudesin precursor  
Size: 172 amino acids; 18856 Da
Subcellular location: Secreted, extracellular space (By similarity)
Secondary accessions: A1KYQ8 Q53FZ6 Q5TM90

Explore the universe of human proteins at neXtProt for NENF: NX_Q9UMX5

Explore proteomics data for NENF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMX5

  • NENF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NENF Protein Expression
    REFSEQ proteins: NP_037481.1  
    ENSEMBL proteins: 
     ENSP00000355955  

    Human Recombinant Protein Products for NENF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NENF (Neudesin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NENF
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for NENF 
    OriGene Custom Protein Services for NENF
    GenScript Custom Purified and Recombinant Proteins Services for NENF
    Novus Biologicals NENF Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NENF 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    NENF for ontologies           About GeneDecksing



    NENF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NENF
    R&D Systems Antibodies for NENF (Neudesin)
    OriGene Antibodies for NENF
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    Novus Biologicals NENF Antibodies
    Abcam antibodies for NENF
    Cloud-Clone Corp. Antibodies for NENF 
    ThermoFisher Antibodies for NENF
    LSBio Antibodies in human, mouse, rat for NENF 

    Assay Products for NENF: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NENF
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    Cloud-Clone Corp. ELISAs for NENF 
    Cloud-Clone Corp. CLIAs for NENF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry Q9UMX5

    ProtoNet protein and cluster: Q9UMX5

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
    Domain: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved
    iron-binding His residue at position 82 (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    NENF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NENF_HUMAN, Q9UMX5
    Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
    primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on
    neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells.
    Neurotrophic activity is enhanced by binding to heme (By similarity)
    Induction: Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing
    progesterone receptor

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    NENF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NENF:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NENF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NENF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NENF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NENF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NENF
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmidNENF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NENF (NM_013349)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NENF

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043410positive regulation of MAPK cascade IEA--

    NENF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NENF

    2 HMDB Compounds for NENF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    Search CenterWatch for drugs/clinical trials and news about NENF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NENF gene: 
    NM_013349.4  

    Unigene Cluster for NENF:

    Neudesin neurotrophic factor
    Hs.461787  [show with all ESTs]
    Unigene Representative Sequence: BU502624
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366988(uc001hjd.3 uc010ptf.2) ENST00000479589 ENST00000473900
    ENST00000472389
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmidNENF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NENF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NENF
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    OriGene qPCR primer pairs and template standards for NENF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NENF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NENF

    Additional mRNA sequence: 

    AB126219.1 AF000267.1 AF049672.1 AF173937.1 AK074431.1 AK223135.1 AY762102.1 BC008823.2 
    NR_026598.1 

    13 DOTS entries:

    DT.118861  DT.101956271  DT.100036815  DT.92433314  DT.100637912  DT.100861921  DT.121438068  DT.100641834 
    DT.121438145  DT.100647155  DT.92433318  DT.92433319  DT.95222043 

    24/139 AceView cDNA sequences (see all 139):

    BM740482 AW025767 BF811404 BM678055 AA074675 BE395739 BM793409 BM687084 
    AW058078 CA313613 BM725580 AA775277 AW168702 AA365946 AA886977 AA773414 
    AA295887 F35860 BI547543 AW328249 AA934086 CD364983 AA679297 AA075294 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NENF    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                                 
    SP2:                                                      
    SP3:                    -     -                           
    SP4:                                -                     


    ECgene alternative splicing isoforms for NENF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NENF expression in normal human tissues (normalized intensities)      NENF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTACGGG
    NENF Expression
    About this image


    NENF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             mouth   
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord

    See NENF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NENF

    SOURCE GeneReport for Unigene cluster: Hs.461787
        SABiosciences Custom PCR Arrays for NENF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NENF gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nenf1 , 5 neuron derived neurotrophic factor1, 5 88.5(n)1
    91.23(a)1
      1 (96.28 cM)5
    662081  NM_025424.21  NP_079700.11 
     1913067895 
    chicken
    (Gallus gallus)
    Aves NENF1 neudesin neurotrophic factor 75.42(n)
    76.25(a)
      421370  XM_419430.2  XP_419430.1 
    lizard
    (Anolis carolinensis)
    Reptilia NENF6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    1(238523110-238527967)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67872 Transcribed sequence with weak similarity to protein more 73.42(n)    142017620 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11a042 wufa11a04 76.98(n)   334967  CF347670.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAP16
    Heme-binding protein involved in regulation of cyt...
    24(a)
    1 → many
    XVI(228314-228772)
    rice
    (Oryza sativa)
    Liliopsida Os10g05025001 hypothetical protein 53.42(n)
    42.47(a)
      4349045  NM_001071527.1  NP_001064992.1 


    ENSEMBL Gene Tree for NENF (if available)
    TreeFam Gene Tree for NENF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NENF gene
    CYB5D22  
    2 SIMAP similar genes for NENF using alignment to 1 protein entry:     NENF_HUMAN:
    CYB5D2    PGRMC1

    NENF for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NENF
    PGOHUM00000239908 PGOHUM00000244005 PGOHUM00000235124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/345 SNPs in NENF are shown (see all 345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459901781,2
    --212604288(+) GCTTTC/GTGACT 2 -- us2k10--------
    rs1146717131,2
    F--212604381(+) GATGGA/GTCTCT 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1901726551,2
    --212604390(+) CTGTCC/TCCCTG 2 -- us2k10--------
    rs1399842181,2
    --212604503(+) CAAACA/CTGCTG 2 -- us2k10--------
    rs1816094531,2
    --212604637(+) AAATTA/CTCCCT 2 -- us2k10--------
    rs121335821,2
    C,F,A,H--212604885(+) ACTATG/ACTCTG 2 -- us2k120Minor allele frequency- A:0.20NS EA NA WA CSA 2346
    rs1855899251,2
    --212604924(+) GTCTAA/CGAACC 2 -- us2k10--------
    rs781867521,2
    C,F--212604938(+) TCTTGG/TGTCTG 2 -- us2k12Minor allele frequency- T:0.13CSA WA 120
    rs127553831,2
    C,F--212604966(+) TGTTAA/GTTCCT 2 -- us2k1 tfbs36Minor allele frequency- G:0.11NA WA 246
    rs1115064861,2
    C,F--212605221(+) TCAGTG/AAGGCC 2 -- us2k12Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for NENF (212606229 - 212619721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NENF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527863CNV Loss19592680
    dgv527n71CNV Loss21882294
    nsv873162CNV Loss21882294
    dgv526n71CNV Loss21882294
    nsv873156CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NENF
    DNA2.0 Custom Variant and Variant Library Synthesis for NENF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611874    OMIM disorders: --

    4 diseases for NENF:    About MalaCards
    spinal cord injury    estrogen-receptor positive breast cancer    neuronitis    breast cancer


    NENF for disorders           About GeneDecksing


    Export disorders for NENF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NENF gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with NENF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. (PubMed id 15605373)1, 2, 3, 9 Kimura I....Itoh N. (2005)
    2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. (PubMed id 9771976)1, 2, 3 Ma L.... Bacchetti S. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. (PubMed id 18056703)1, 9 Kimura I....Fujimoto M. (2008)
    5. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. (PubMed id 16645950)2, 9 Neubauer H.... Cahill M.A. (2006)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29937 HGNC: 30384 AceView: SPUF Ensembl:ENSG00000117691 euGenes: HUgn29937
    ECgene: NENF H-InvDB: NENF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for NENF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for NENF gene:
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