Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NENF Gene

Aliases for NENF Gene

  • Neudesin Neurotrophic Factor 2 3 5
  • Cell Immortalization-Related Protein 2 3 4
  • Secreted Protein Of Unknown Function 3 4
  • Neuron-Derived Neurotrophic Factor 3 4
  • CIR2 3 4
  • SPUF 3 4
  • Spinal Cord Injury Related Protein 10 3
  • Neuron Derived Neurotrophic Factor 2
  • Cell Growth-Inhibiting Protein 47 3
  • SCIRP10-Related Protein 3
  • Protein GIG47 4
  • SPUF Protein 4
  • Neudesin 2
  • SCIRP10 3

External Ids for NENF Gene

Previous GeneCards Identifiers for NENF Gene

  • GC01P208996
  • GC01P210672
  • GC01P212606
  • GC01P183282

Summaries for NENF Gene

Entrez Gene Summary for NENF Gene

  • This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for NENF Gene

NENF (Neudesin Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include growth factor activity and heme binding. An important paralog of this gene is CYB5D2.

UniProtKB/Swiss-Prot for NENF Gene

  • Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NENF Gene

Genomics for NENF Gene

Regulatory Elements for NENF Gene

Enhancers for NENF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NENF on UCSC Golden Path with GeneCards custom track

Promoters for NENF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NENF on UCSC Golden Path with GeneCards custom track

Genomic Location for NENF Gene

Chromosome:
1
Start:
212,432,887 bp from pter
End:
212,446,379 bp from pter
Size:
13,493 bases
Orientation:
Plus strand

Genomic View for NENF Gene

Genes around NENF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NENF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NENF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NENF Gene

Proteins for NENF Gene

  • Protein details for NENF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMX5-NENF_HUMAN
    Recommended name:
    Neudesin
    Protein Accession:
    Q9UMX5
    Secondary Accessions:
    • A1KYQ8
    • Q53FZ6
    • Q5TM90

    Protein attributes for NENF Gene

    Size:
    172 amino acids
    Molecular mass:
    18856 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NENF Gene

Proteomics data for NENF Gene at MOPED

Post-translational modifications for NENF Gene

  • Ubiquitination at Lys 79
  • Glycosylation at Thr 48, Thr 76, Thr 92, Ser 96, and Thr 143
  • Modification sites at PhosphoSitePlus

Other Protein References for NENF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NENF Gene

Domains & Families for NENF Gene

Protein Domains for NENF Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NENF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMX5

UniProtKB/Swiss-Prot:

NENF_HUMAN :
  • The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
Domain:
  • The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with NENF: view

No data available for Gene Families for NENF Gene

Function for NENF Gene

Molecular function for NENF Gene

UniProtKB/Swiss-Prot Function:
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).
UniProtKB/Swiss-Prot Induction:
Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing progesterone receptor.
genes like me logo Genes that share phenotypes with NENF: view

Animal Models for NENF Gene

MGI Knock Outs for NENF:

Animal Model Products

  • Taconic Biosciences Mouse Models for NENF

miRNA for NENF Gene

miRTarBase miRNAs that target NENF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NENF Gene

Localization for NENF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NENF Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NENF Gene COMPARTMENTS Subcellular localization image for NENF gene
Compartment Confidence
nucleus 5
extracellular 4
endoplasmic reticulum 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NENF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with NENF: view

Pathways & Interactions for NENF Gene

SuperPathways for NENF Gene

No Data Available

Interacting Proteins for NENF Gene

Gene Ontology (GO) - Biological Process for NENF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NENF Gene

Drugs & Compounds for NENF Gene

(1) Drugs for NENF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for NENF Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with NENF: view

Transcripts for NENF Gene

Unigene Clusters for NENF Gene

Neudesin neurotrophic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NENF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for NENF Gene

GeneLoc Exon Structure for
NENF
ECgene alternative splicing isoforms for
NENF

Expression for NENF Gene

mRNA expression in normal human tissues for NENF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NENF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NENF Gene



SOURCE GeneReport for Unigene cluster for NENF Gene Hs.461787

mRNA Expression by UniProt/SwissProt for NENF Gene

Q9UMX5-NENF_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
genes like me logo Genes that share expression patterns with NENF: view

Protein tissue co-expression partners for NENF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NENF Gene

Orthologs for NENF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NENF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NENF 35
  • 89.94 (n)
  • 92.31 (a)
NENF 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nenf 35
  • 89.8 (n)
  • 95.24 (a)
Nenf 16
Nenf 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NENF 35
  • 99.81 (n)
  • 100 (a)
NENF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nenf 35
  • 88.66 (n)
  • 92.52 (a)
dog
(Canis familiaris)
Mammalia NENF 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NENF 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves NENF 35
  • 79.23 (n)
  • 83.33 (a)
NENF 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NENF 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nenf 35
  • 67.61 (n)
  • 73.24 (a)
Str.6787 35
zebrafish
(Danio rerio)
Actinopterygii nenf 35
  • 68.97 (n)
  • 76.92 (a)
wufa11a04 35
nenf 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10963 35
fruit fly
(Drosophila melanogaster)
Insecta CG12056 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-131 36
  • 13 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MAPR2 35
  • 57.09 (n)
  • 50 (a)
rice
(Oryza sativa)
Liliopsida Os02g0793700 35
  • 58.06 (n)
  • 45.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9270 36
  • 15 (a)
OneToMany
Species with no ortholog for NENF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NENF Gene

ENSEMBL:
Gene Tree for NENF (if available)
TreeFam:
Gene Tree for NENF (if available)

Paralogs for NENF Gene

Paralogs for NENF Gene

(2) SIMAP similar genes for NENF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NENF Gene

genes like me logo Genes that share paralogs with NENF: view

Variants for NENF Gene

Sequence variations from dbSNP and Humsavar for NENF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4804 -- 212,445,997(+) AAGGA(C/T)GAGTT nc-transcript-variant, reference, synonymous-codon
rs472463 -- 212,439,399(-) atgct(C/T)ggcta intron-variant
rs479807 -- 212,440,203(-) acaat(A/C)tcggc intron-variant
rs483954 -- 212,446,872(+) GTCCG(A/G)AATTT downstream-variant-500B
rs589669 -- 212,444,680(+) ACTCA(G/T)AAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NENF Gene

Variant ID Type Subtype PubMed ID
nsv873156 CNV Gain 21882294
dgv526n71 CNV Loss 21882294
dgv527n71 CNV Loss 21882294
nsv873162 CNV Loss 21882294
nsv527863 CNV Loss 19592680

Variation tolerance for NENF Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NENF Gene

HapMap Linkage Disequilibrium report
NENF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NENF Gene

Disorders for NENF Gene

Relevant External Links for NENF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NENF

No disorders were found for NENF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NENF Gene

Publications for NENF Gene

  1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. (PMID: 15605373) Kimura I. … Itoh N. (J. Neurosci. Res. 2005) 2 3 4 23 67
  2. Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. (PMID: 18056703) Kimura I. … Fujimoto M. (J. Biol. Chem. 2008) 3 23
  3. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. (PMID: 9771976) Ma L. … Bacchetti S. (Oncogene 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NENF Gene

Sources for NENF Gene

Content