Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NENF Gene

protein-coding   GIFtS: 55
GCID: GC01P212606

Neudesin Neurotrophic Factor

(Previous name: neuron derived neurotrophic factor)
  See NENF-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neudesin Neurotrophic Factor1 2     Neuron Derived Neurotrophic Factor1
CIR22 3 5     SCIRP102
neudesin1 2     Cell Growth-Inhibiting Protein 472
Cell Immortalization-Related Protein 22 3     SCIRP10-Related Protein2
Neuron-Derived Neurotrophic Factor2 3     Spinal Cord Injury Related Protein 102
Secreted Protein Of Unknown Function2 3     SPUF Protein3
SPUF2 3     

External Ids:    HGNC: 303841   Entrez Gene: 299372   Ensembl: ENSG000001176917   OMIM: 6118745   UniProtKB: Q9UMX53   
ORGUL members:         

Export aliases for NENF gene to outside databases

Previous GC identifers: GC01P208996 GC01P210672 GC01P183282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NENF Gene:
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A
pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript
variants. (provided by RefSeq, Jan 2009)

GeneCards Summary for NENF Gene:
NENF (neudesin neurotrophic factor) is a protein-coding gene. Diseases associated with NENF include spinal cord injury. GO annotations related to this gene include growth factor activity and heme binding. An important paralog of this gene is CYB5D2.

UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on
neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells.
Neurotrophic activity is enhanced by binding to heme (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NENF gene promoter:
         Elk-1   LHX3b/Lhx3b   STAT1   STAT1beta   STAT5A   STAT1alpha   COMP1   LHX3a/Lhx3a   IRF-7A   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNENF promoter sequence
   Search Chromatin IP Primers for NENF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NENF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

NENF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NENF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212606:  view genomic region     (about GC identifiers)

Start:
212,606,229 bp from pter      End:
212,619,721 bp from pter
Size:
13,493 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5 (See protein sequence)
Recommended Name: Neudesin precursor  
Size: 172 amino acids; 18856 Da
Secondary accessions: A1KYQ8 Q53FZ6 Q5TM90

Explore the universe of human proteins at neXtProt for NENF: NX_Q9UMX5

Explore proteomics data for NENF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79
  • Glycosylation2 at Thr48, Thr76, Thr92, Ser96, Thr143
  • Modification sites at PhosphoSitePlus

  • See NENF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037481.1  
    ENSEMBL proteins: 
     ENSP00000355955  

    NENF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NENF (Neudesin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NENF
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for NENF
    OriGene Custom Protein Services for NENF
    GenScript Custom Purified and Recombinant Proteins Services for NENF
    Novus Biologicals NENF Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NENF
    Cloud-Clone Corp. Proteins for NENF

     
    Search eBioscience for Proteins for NENF 

    NENF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NENF
    R&D Systems Antibodies for NENF (Neudesin)
    OriGene Antibodies for NENF
    OriGene Custom Antibody Services for NENF
    Novus Biologicals NENF Antibodies
    Abcam antibodies for NENF
    Cloud-Clone Corp. Antibodies for NENF
    ThermoFisher Antibodies for NENF
    LSBio Antibodies in human, mouse, rat for NENF

    NENF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NENF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NENF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NENF
    Cloud-Clone Corp. CLIAs for NENF
    Search eBioscience for ELISAs for NENF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry Q9UMX5

    ProtoNet protein and cluster: Q9UMX5

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: NENF_HUMAN, Q9UMX5
    Domain: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved
    iron-binding His residue at position 82 (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    Find genes that share domains with NENF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NENF_HUMAN, Q9UMX5
    Function: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in
    primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on
    neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells.
    Neurotrophic activity is enhanced by binding to heme (By similarity)
    Induction: Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing
    progesterone receptor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NENF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NENF:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NENF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NENF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NENF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NENF

    miRNA
    Products:
        
    miRTarBase miRNAs that target NENF:
    hsa-mir-186-5p (MIRT045242)

    Block miRNA regulation of human, mouse, rat NENF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmidNENF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NENF
    Predesigned siRNA for gene silencing in human, mouse, rat NENF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NENF

    Clone
    Products:
         
    OriGene clones in human, mouse for NENF (see all 6)
    OriGene ORF clones in mouse, rat for NENF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NENF (NM_013349)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NENF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NENF
    Browse ESI BIO Cell Lines and PureStem Progenitors for NENF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NENF_HUMAN, Q9UMX5: Secreted, extracellular space (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with NENF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NENF
    Interactions:

        Search GeneGlobe Interaction Network for NENF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for NENF (ENSP000003559554) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GYS1ENSP000003179044STRING: ENSP00000317904
    GYS2ENSP000002611954STRING: ENSP00000261195
    CYP39A1ENSP000002750164STRING: ENSP00000275016
    CYP51A1ENSP000000031004STRING: ENSP00000003100
    CYP7A1ENSP000003016454STRING: ENSP00000301645
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043410positive regulation of MAPK cascade IEA--

    Find genes that share ontologies with NENF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NENF

    2 HMDB Compounds for NENF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NENF gene: 
    NM_013349.4  

    Unigene Cluster for NENF:

    Neudesin neurotrophic factor
    Hs.461787  [show with all ESTs]
    Unigene Representative Sequence: BU502624
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366988(uc001hjd.3 uc010ptf.2) ENST00000479589 ENST00000473900
    ENST00000472389
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NENF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NENF
    SwitchGear 3'UTR luciferase reporter plasmidNENF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NENF
    Predesigned siRNA for gene silencing in human, mouse, rat NENF
    Clone
    Products:
         
    OriGene clones in human, mouse for NENF (see all 6)
    OriGene ORF clones in mouse, rat for NENF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NENF (NM_013349)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NENF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NENF
    OriGene qSTAR qPCR primer pairs in human, mouse for NENF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NENF
      QuantiTect SYBR Green Assays in human, mouse, rat NENF
      QuantiFast Probe-based Assays in human, mouse, rat NENF

    Additional mRNA sequence: 

    AB126219.1 AF000267.1 AF049672.1 AF173937.1 AK074431.1 AK223135.1 AY762102.1 BC008823.2 
    NR_026598.1 

    13 DOTS entries:

    DT.118861  DT.101956271  DT.100036815  DT.92433314  DT.100637912  DT.100861921  DT.121438068  DT.100641834 
    DT.121438145  DT.100647155  DT.92433318  DT.92433319  DT.95222043 

    Selected AceView cDNA sequences (see all 139):

    CA313613 BM740482 BF811404 BM793409 AW058078 AA074675 BM687084 BM725580 
    AW025767 AW168702 BM678055 BE395739 AA775277 AA295887 BM874012 BI547543 
    AA365946 BI601881 W81040 AA886977 AI202185 BF475349 AA074898 D31417 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NENF    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                                 
    SP2:                                                      
    SP3:                    -     -                           
    SP4:                                -                     


    ECgene alternative splicing isoforms for NENF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NENF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTACGGG
    NENF Expression
    About this image


    NENF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
    NENF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NENF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461787
        Custom PCR Arrays for NENF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NENF
    OriGene qSTAR qPCR primer pairs in human, mouse for NENF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NENF
    QuantiTect SYBR Green Assays in human, mouse, rat NENF
    QuantiFast Probe-based Assays in human, mouse, rat NENF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NENF gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nenf1 , 5 neuron derived neurotrophic factor1, 5 89.8(n)1
    95.24(a)1
      1 (96.28 cM)5
    662081  NM_025424.21  NP_079700.11 
     1913067895 
    chicken
    (Gallus gallus)
    Aves NENF1 neudesin neurotrophic factor 79.23(n)
    83.33(a)
      421370  XM_419430.3  XP_419430.1 
    lizard
    (Anolis carolinensis)
    Reptilia NENF6
    neudesin neurotrophic factor
    80(a)
    1 ↔ 1
    1(238523110-238527967)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67872 Transcribed sequence with weak similarity to protein more 73.42(n)    142017620 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11a042 wufa11a04 76.98(n)   334967  CF347670.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120566
    --
    14(a)
    1 → many
    X(9086702-9087653)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1316
    Protein TAG-131 (tag-131) mRNA, complete cds
    13(a)
    1 → many
    III(4317700-4320339) WBGene00006478
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAPR21 MAPR2 57.09(n)
    50(a)
      817032  NM_128052.4  NP_180066.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07937001 Os02g0793700 58.06(n)
    45.16(a)
      4330990  NM_001054906.1  NP_001048371.1 


    ENSEMBL Gene Tree for NENF (if available)
    TreeFam Gene Tree for NENF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NENF gene
    CYB5D22  
    2 SIMAP similar genes for NENF using alignment to 1 protein entry:     NENF_HUMAN:
    CYB5D2    PGRMC1

    Find genes that share paralogs with NENF           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NENF
    PGOHUM00000239908 PGOHUM00000244005 PGOHUM00000235124


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NENF (see all 345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459901781,2
    --212604288(+) GCTTTC/GTGACT 2 -- us2k10--------
    rs1146717131,2
    F--212604381(+) GATGGA/GTCTCT 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1901726551,2
    --212604390(+) CTGTCC/TCCCTG 2 -- us2k10--------
    rs1399842181,2
    --212604503(+) CAAACA/CTGCTG 2 -- us2k10--------
    rs1816094531,2
    --212604637(+) AAATTA/CTCCCT 2 -- us2k10--------
    rs121335821,2
    C,F,A,H--212604885(+) ACTATG/ACTCTG 2 -- us2k120Minor allele frequency- A:0.20NS EA NA WA CSA 2346
    rs1855899251,2
    --212604924(+) GTCTAA/CGAACC 2 -- us2k10--------
    rs781867521,2
    C,F--212604938(+) TCTTGG/TGTCTG 2 -- us2k12Minor allele frequency- T:0.13CSA WA 120
    rs127553831,2
    C,F--212604966(+) TGTTAA/GTTCCT 2 -- us2k1 tfbs36Minor allele frequency- G:0.11NA WA 246
    rs1115064861,2
    C,F--212605221(+) TCAGTG/AAGGCC 2 -- us2k12Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for NENF (212606229 - 212619721 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NENF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527863CNV Loss19592680
    dgv527n71CNV Loss21882294
    nsv873162CNV Loss21882294
    dgv526n71CNV Loss21882294
    nsv873156CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NENF
    DNA2.0 Custom Variant and Variant Library Synthesis for NENF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611874    OMIM disorders: --

    1 disease for NENF:    
    About MalaCards
    spinal cord injury


    Find genes that share disorders with NENF           About GenesLikeMe


    Export disorders for NENF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NENF gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with NENF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. (PubMed id 15605373)1, 2, 3, 9 Kimura I.... Itoh N. (J. Neurosci. Res. 2005)
    2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. (PubMed id 9771976)1, 2, 3 Ma L.... Bacchetti S. (Oncogene 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. (PubMed id 18056703)1, 9 Kimura I....Fujimoto M. (J. Biol. Chem. 2008)
    5. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. (PubMed id 16645950)2, 9 Neubauer H.... Cahill M.A. (Electrophoresis 2006)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29937 HGNC: 30384 AceView: SPUF Ensembl:ENSG00000117691 euGenes: HUgn29937
    ECgene: NENF H-InvDB: NENF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NENF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NENF gene:
    Search GeneIP for patents involving NENF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NENF
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for NENF (Neudesin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NENF (Neudesin)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NENF   OriGene RNAi products in human, mouse, rat for NENF  
     OriGene qPCR primer pairs and template standards for NENF   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for NENF   OriGene clones in human, mouse for NENF  
     OriGene qSTAR qPCR primer pairs in human, mouse for NENF   OriGene Purified Protein for NENF  
     OriGene ORF clones in mouse, rat for NENF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NENF   OriGene Custom Protein Services for NENF  

     
     
     Block miRNA regulation of human, mouse, rat NENF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NENF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NENF Predesigned siRNA for gene silencing in human, mouse, rat NENF
     QuantiFast Probe-based Assays in human, mouse, rat NENF QuantiTect SYBR Green Assays in human, mouse, rat NENF
     Custom PCR Arrays for NENF Search Chromatin IP Primers for NENF
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NENF Search GeneGlobe Interaction Network for NENF
     Regulatory tfbs in NENF promoter
     GenScript Custom Purified and Recombinant Proteins Services for NENF GenScript cDNA clones with any tag delivered in your preferred vector for NENF
     GenScript Custom Assay Services for NENF GenScript Custom overexpressing Cell Line Services for NENF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NENF
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NENF antibodies
     NENF proteins
     Antibodies for NENF
     See all of Abcam's Antibodies, Kits and Proteins for NENF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NENF
     Proteins for NENF
     Antibodies for NENF
     ELISAs for NENF
     CLIAs for NENF



     Browse ESI BIO Cell Lines and PureStem Progenitors for NENF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NENF
     SwitchGear 3'UTR luciferase reporter plasmids for NENF
     SwitchGear Promoter luciferase reporter plasmids for NENF
     ThermoFisher Antibodies for NENF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NENF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NENF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NENF
     LSBio Antibodies in human, mouse, rat for NENF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NENF
      Search eBioscience for proteins for NENF
      Search eBioscience for elisas for NENF
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NENF gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4