Aliases for NENF Gene
External Ids for NENF Gene
Previous GeneCards Identifiers for NENF Gene
This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
GeneCards Summary for NENF Gene
NENF (Neudesin Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include growth factor activity and heme binding. An important paralog of this gene is CYB5D2.
UniProtKB/Swiss-Prot for NENF Gene
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).