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Aliases for NENF Gene

Aliases for NENF Gene

  • Neudesin Neurotrophic Factor 2 3 5
  • Cell Immortalization-Related Protein 2 3 4
  • Secreted Protein Of Unknown Function 3 4
  • Neuron-Derived Neurotrophic Factor 3 4
  • Neudesin 2 3
  • CIR2 3 4
  • SPUF 3 4
  • Spinal Cord Injury Related Protein 10 3
  • Neuron Derived Neurotrophic Factor 2
  • Cell Growth-Inhibiting Protein 47 3
  • SCIRP10-Related Protein 3
  • Protein GIG47 4
  • SPUF Protein 4
  • SCIRP10 3

External Ids for NENF Gene

Previous GeneCards Identifiers for NENF Gene

  • GC01P208996
  • GC01P210672
  • GC01P212606
  • GC01P183282

Summaries for NENF Gene

Entrez Gene Summary for NENF Gene

  • This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for NENF Gene

NENF (Neudesin Neurotrophic Factor) is a Protein Coding gene. GO annotations related to this gene include growth factor activity and heme binding. An important paralog of this gene is CYB5D2.

UniProtKB/Swiss-Prot for NENF Gene

  • Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NENF Gene

Genomics for NENF Gene

Regulatory Elements for NENF Gene

Enhancers for NENF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G212476 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +44.9 44886 1.7 PKNOX1 ATF1 WRNIP1 BRCA1 YY1 ZNF766 GATA2 ELK1 ZNF143 KLF13 LOC105372907 ATF3 NENF FAM71A ENSG00000235862 BATF3 TMEM206 ENSG00000212187 VASH2 LOC105372908
GH01G212469 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +37.4 37394 1.3 ZNF687 L3MBTL2 RNF2 NRF1 BHLHE40 DPF2 FOSL1 RAD51 JUND FOS NENF FAM71A ENSG00000235862 ATF3 TMEM206 BATF3 LOC105372907 ENSG00000212187 VASH2
GH01G212497 1.2 Ensembl ENCODE 11.2 +65.5 65494 1.1 FOXA2 KLF17 ZNF2 KAT2B ZNF335 GLIS2 ZNF366 EGR1 FOS IKZF2 LOC105372907 ATF3 NENF BATF3 TMEM206 LOC105372908
GH01G212471 0.7 dbSUPER 11.9 +39.2 39247 1.8 ATF1 FOXA2 CEBPG ZNF664 ZNF316 GATA2 SCRT2 NFE2 MAFK NFE2L2 LOC105372907 NENF FAM71A ENSG00000235862 ATF3 BATF3 TMEM206 ENSG00000212187 VASH2
GH01G212449 0.9 ENCODE dbSUPER 9 +18.0 18040 2.0 SCRT1 ZSCAN4 CEBPB CEBPG ATF2 ZBTB49 SMARCA4 POLR2A SCRT2 NENF LINC01740 TMEM206 LOC105372907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NENF on UCSC Golden Path with GeneCards custom track

Promoters for NENF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019704 213 1401 ARNT SIN3A FEZF1 ZNF2 ZNF143 ZNF207 SP3 SP5 REST SMARCB1

Genomic Location for NENF Gene

Chromosome:
1
Start:
212,432,887 bp from pter
End:
212,446,379 bp from pter
Size:
13,493 bases
Orientation:
Plus strand

Genomic View for NENF Gene

Genes around NENF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NENF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NENF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NENF Gene

Proteins for NENF Gene

  • Protein details for NENF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMX5-NENF_HUMAN
    Recommended name:
    Neudesin
    Protein Accession:
    Q9UMX5
    Secondary Accessions:
    • A1KYQ8
    • Q53FZ6
    • Q5TM90

    Protein attributes for NENF Gene

    Size:
    172 amino acids
    Molecular mass:
    18856 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NENF Gene

Post-translational modifications for NENF Gene

  • Ubiquitination at posLast=7979
  • Glycosylation at Thr48, posLast=7676, Thr92, posLast=9696, and Thr143
  • Modification sites at PhosphoSitePlus

Other Protein References for NENF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NENF Gene

Domains & Families for NENF Gene

Protein Domains for NENF Gene

Suggested Antigen Peptide Sequences for NENF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMX5

UniProtKB/Swiss-Prot:

NENF_HUMAN :
  • The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
Domain:
  • The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with NENF: view

Function for NENF Gene

Molecular function for NENF Gene

UniProtKB/Swiss-Prot Function:
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).
UniProtKB/Swiss-Prot Induction:
Up-regulated in immortal cells. Induced in estrogen receptor positive breast cancer expressing progesterone receptor.

Gene Ontology (GO) - Molecular Function for NENF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NENF: view
genes like me logo Genes that share phenotypes with NENF: view

Animal Models for NENF Gene

MGI Knock Outs for NENF:

Animal Model Products

  • Taconic Biosciences Mouse Models for NENF

CRISPR Products

miRNA for NENF Gene

miRTarBase miRNAs that target NENF

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NENF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NENF Gene

Localization for NENF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NENF Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NENF gene
Compartment Confidence
extracellular 4
nucleus 3
mitochondrion 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for NENF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with NENF: view

Pathways & Interactions for NENF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NENF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032099 negative regulation of appetite IEA,ISS --
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with NENF: view

No data available for Pathways by source and SIGNOR curated interactions for NENF Gene

Drugs & Compounds for NENF Gene

(1) Drugs for NENF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0

(1) Additional Compounds for NENF Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with NENF: view

Transcripts for NENF Gene

Unigene Clusters for NENF Gene

Neudesin neurotrophic factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NENF

Alternative Splicing Database (ASD) splice patterns (SP) for NENF Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for NENF Gene

GeneLoc Exon Structure for
NENF
ECgene alternative splicing isoforms for
NENF

Expression for NENF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NENF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NENF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NENF Gene



Protein tissue co-expression partners for NENF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NENF Gene:

NENF

SOURCE GeneReport for Unigene cluster for NENF Gene:

Hs.461787

mRNA Expression by UniProt/SwissProt for NENF Gene:

Q9UMX5-NENF_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.

Evidence on tissue expression from TISSUES for NENF Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Lung(3.6)
  • Muscle(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with NENF: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NENF Gene

Orthologs for NENF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NENF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NENF 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia NENF 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NENF 34 35
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Nenf 34 16 35
  • 89.8 (n)
rat
(Rattus norvegicus)
Mammalia Nenf 34
  • 88.66 (n)
oppossum
(Monodelphis domestica)
Mammalia NENF 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves NENF 34 35
  • 79.23 (n)
lizard
(Anolis carolinensis)
Reptilia NENF 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nenf 34
  • 67.61 (n)
Str.6787 34
zebrafish
(Danio rerio)
Actinopterygii nenf 34 35
  • 68.97 (n)
wufa11a04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10963 34
fruit fly
(Drosophila melanogaster)
Insecta CG12056 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-131 35
  • 13 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MAPR2 34
  • 57.09 (n)
rice
(Oryza sativa)
Liliopsida Os02g0793700 34
  • 58.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9270 35
  • 15 (a)
OneToMany
Species where no ortholog for NENF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NENF Gene

ENSEMBL:
Gene Tree for NENF (if available)
TreeFam:
Gene Tree for NENF (if available)

Paralogs for NENF Gene

Paralogs for NENF Gene

(2) SIMAP similar genes for NENF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NENF Gene

genes like me logo Genes that share paralogs with NENF: view

Variants for NENF Gene

Sequence variations from dbSNP and Humsavar for NENF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000042699 -- 212,444,625(+) TTGGT(A/G)TGGTG intron-variant
rs1000093816 -- 212,438,751(+) AGCTG(G/T)GATTA intron-variant
rs1000889854 -- 212,440,702(+) GCCTG(A/T)GTGGT intron-variant
rs1001004958 -- 212,446,865(+) TCATC(C/T)GGTCC downstream-variant-500B
rs1001036329 -- 212,446,602(+) GAGGA(G/T)GGCCG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NENF Gene

Variant ID Type Subtype PubMed ID
nsv1119756 CNV deletion 24896259
nsv527863 CNV loss 19592680
nsv549139 CNV gain 21841781

Variation tolerance for NENF Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NENF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NENF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NENF Gene

Disorders for NENF Gene

Relevant External Links for NENF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NENF

No disorders were found for NENF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NENF Gene

Publications for NENF Gene

  1. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. (PMID: 15605373) Kimura I. … Itoh N. (J. Neurosci. Res. 2005) 2 3 4 22 64
  2. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. (PMID: 9771976) Ma L. … Bacchetti S. (Oncogene 1998) 2 3 4 64
  3. Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain. (PMID: 18056703) Kimura I. … Fujimoto M. (J. Biol. Chem. 2008) 3 22 64
  4. Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. (PMID: 16645950) Neubauer H. … Cahill M.A. (Electrophoresis 2006) 4 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NENF Gene

Sources for NENF Gene

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