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Aliases for NEMP2 Gene

Aliases for NEMP2 Gene

  • Nuclear Envelope Integral Membrane Protein 2 2 3 5
  • Transmembrane Protein 194B 2 3
  • TMEM194B 3 4
  • UPF0571 Transmembrane Protein 3

External Ids for NEMP2 Gene

Previous HGNC Symbols for NEMP2 Gene

  • TMEM194B

Summaries for NEMP2 Gene

GeneCards Summary for NEMP2 Gene

NEMP2 (Nuclear Envelope Integral Membrane Protein 2) is a Protein Coding gene. An important paralog of this gene is NEMP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP2 Gene

Genomics for NEMP2 Gene

Regulatory Elements for NEMP2 Gene

Enhancers for NEMP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NEMP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEMP2 Gene

190,454,092 bp from pter
190,543,625 bp from pter
89,534 bases
Minus strand

Genomic View for NEMP2 Gene

Genes around NEMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP2 Gene

Proteins for NEMP2 Gene

  • Protein details for NEMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear envelope integral membrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DYG6

    Protein attributes for NEMP2 Gene

    417 amino acids
    Molecular mass:
    48664 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEMP2 Gene


neXtProt entry for NEMP2 Gene

Post-translational modifications for NEMP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEMP2 Gene

No data available for DME Specific Peptides for NEMP2 Gene

Domains & Families for NEMP2 Gene

Protein Domains for NEMP2 Gene


Suggested Antigen Peptide Sequences for NEMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NEMP family.
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP2: view

No data available for Gene Families for NEMP2 Gene

Function for NEMP2 Gene

Phenotypes for NEMP2 Gene

GenomeRNAi human phenotypes for NEMP2:
genes like me logo Genes that share phenotypes with NEMP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEMP2 Gene

Localization for NEMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP2 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side.

Gene Ontology (GO) - Cellular Components for NEMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NEMP2: view

No data available for Subcellular locations from COMPARTMENTS for NEMP2 Gene

Pathways & Interactions for NEMP2 Gene

SuperPathways for NEMP2 Gene

No Data Available

Interacting Proteins for NEMP2 Gene

Gene Ontology (GO) - Biological Process for NEMP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NEMP2 Gene

Drugs & Compounds for NEMP2 Gene

No Compound Related Data Available

Transcripts for NEMP2 Gene

mRNA/cDNA for NEMP2 Gene

(8) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP2 Gene

No ASD Table

Relevant External Links for NEMP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEMP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEMP2 Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NEMP2 Gene

Orthologs for NEMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM194B 34
  • 80.75 (n)
  • 72.77 (a)
TMEM194B 35
  • 68 (a)
(Canis familiaris)
Mammalia TMEM194B 34
  • 80 (n)
  • 74.03 (a)
TMEM194B 35
  • 61 (a)
(Mus musculus)
Mammalia Tmem194b 34
  • 80.67 (n)
  • 71.65 (a)
Nemp2 16
Tmem194b 35
  • 69 (a)
(Pan troglodytes)
Mammalia TMEM194B 34
  • 99.12 (n)
  • 98.8 (a)
TMEM194B 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem194b 34
  • 79.64 (n)
  • 70.62 (a)
(Monodelphis domestica)
Mammalia TMEM194B 35
  • 55 (a)
(Gallus gallus)
Aves TMEM194B 34
  • 59.55 (n)
  • 47.09 (a)
TMEM194B 35
  • 41 (a)
(Anolis carolinensis)
Reptilia TMEM194B 35
  • 44 (a)
(Danio rerio)
Actinopterygii tmem194b 34
  • 48.09 (n)
  • 34.64 (a)
tmem194b 35
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9723 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea F10C5.2 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
Species where no ortholog for NEMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEMP2 Gene

Gene Tree for NEMP2 (if available)
Gene Tree for NEMP2 (if available)

Paralogs for NEMP2 Gene

Paralogs for NEMP2 Gene Pseudogenes for NEMP2 Gene

genes like me logo Genes that share paralogs with NEMP2: view

Variants for NEMP2 Gene

Sequence variations from dbSNP and Humsavar for NEMP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4316966 -- 190,503,517(+) GAGAT(A/C)TCTGG intron-variant, utr-variant-3-prime
rs4343494 -- 190,540,120(+) ttttt(A/T)tcata intron-variant
rs4384819 -- 190,540,021(+) tttca(A/G)tttct intron-variant
rs4384820 -- 190,540,085(+) ttgag(A/G)tgttt intron-variant
rs6707244 -- 190,509,049(+) GGTTT(C/T)CCTTT intron-variant, utr-variant-3-prime

Variation tolerance for NEMP2 Gene

Gene Damage Index Score: 5.02; 68.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEMP2 Gene

Disorders for NEMP2 Gene

Relevant External Links for NEMP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEMP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP2 Gene

Publications for NEMP2 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T. … Taira M. (PLoS ONE 2015) 2 3 65
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 65

Products for NEMP2 Gene

Sources for NEMP2 Gene

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