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Aliases for NEMP1 Gene

Aliases for NEMP1 Gene

  • Nuclear Envelope Integral Membrane Protein 1 2 3 5
  • Transmembrane Protein 194A 2 3
  • Transmembrane Protein 194 2 3
  • TMEM194A 3 4
  • TMEM194 3 4
  • KIAA0286 4

External Ids for NEMP1 Gene

Previous HGNC Symbols for NEMP1 Gene

  • TMEM194
  • TMEM194A

Summaries for NEMP1 Gene

GeneCards Summary for NEMP1 Gene

NEMP1 (Nuclear Envelope Integral Membrane Protein 1) is a Protein Coding gene. An important paralog of this gene is NEMP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP1 Gene

Genomics for NEMP1 Gene

Regulatory Elements for NEMP1 Gene

Enhancers for NEMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NEMP1 on UCSC Golden Path with GeneCards custom track

Promoters for NEMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEMP1 Gene

Chromosome:
12
Start:
57,055,643 bp from pter
End:
57,088,857 bp from pter
Size:
33,215 bases
Orientation:
Minus strand

Genomic View for NEMP1 Gene

Genes around NEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP1 Gene

Proteins for NEMP1 Gene

  • Protein details for NEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14524-NEMP1_HUMAN
    Recommended name:
    Nuclear envelope integral membrane protein 1
    Protein Accession:
    O14524
    Secondary Accessions:
    • Q17R72
    • Q68DH0
    • Q6IQ25

    Protein attributes for NEMP1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50640 Da
    Quaternary structure:
    • Homooligomer. Interacts with RAN-GTP.
    SequenceCaution:
    • Sequence=AAH71597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA22955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMP1 Gene

Post-translational modifications for NEMP1 Gene

Other Protein References for NEMP1 Gene

No data available for DME Specific Peptides for NEMP1 Gene

Domains & Families for NEMP1 Gene

Protein Domains for NEMP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14524

UniProtKB/Swiss-Prot:

NEMP1_HUMAN :
  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
Domain:
  • The transmembrane domains are required and sufficient for its oligomerization.
Family:
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP1: view

No data available for Gene Families for NEMP1 Gene

Function for NEMP1 Gene

Gene Ontology (GO) - Molecular Function for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NEMP1: view

Phenotypes for NEMP1 Gene

GenomeRNAi human phenotypes for NEMP1:
genes like me logo Genes that share phenotypes with NEMP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEMP1 Gene

Localization for NEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP1 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250 UniProtKB:Q6ZQE4}.

Gene Ontology (GO) - Cellular Components for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA,ISS --
GO:0005637 nuclear inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NEMP1: view

No data available for Subcellular locations from COMPARTMENTS for NEMP1 Gene

Pathways & Interactions for NEMP1 Gene

SuperPathways for NEMP1 Gene

No Data Available

Interacting Proteins for NEMP1 Gene

Gene Ontology (GO) - Biological Process for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NEMP1: view

No data available for Pathways by source and SIGNOR curated interactions for NEMP1 Gene

Drugs & Compounds for NEMP1 Gene

No Compound Related Data Available

Transcripts for NEMP1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP1 Gene

No ASD Table

Relevant External Links for NEMP1 Gene

GeneLoc Exon Structure for
NEMP1
ECgene alternative splicing isoforms for
NEMP1

Expression for NEMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEMP1 Gene:

NEMP1
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NEMP1 Gene

Orthologs for NEMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM194A 34
  • 89.41 (n)
  • 85.59 (a)
TMEM194A 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM194A 34
  • 91.48 (n)
  • 88.58 (a)
TMEM194A 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nemp1 16
Tmem194 34
  • 85.4 (n)
  • 82.57 (a)
Tmem194 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM194A 34
  • 99.77 (n)
  • 99.55 (a)
TMEM194A 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM194A 35
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem194 34
  • 84.55 (n)
  • 82.88 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM194A 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM194A 35
  • 60 (a)
OneToOne
TMEM194A 34
  • 65.84 (n)
  • 63.95 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM194A 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3173 34
tmem194a 34
  • 65.81 (n)
  • 64.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem194a 34
  • 59.98 (n)
  • 54.76 (a)
tmem194a 35
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9723 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10C5.2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for NEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEMP1 Gene

ENSEMBL:
Gene Tree for NEMP1 (if available)
TreeFam:
Gene Tree for NEMP1 (if available)

Paralogs for NEMP1 Gene

Paralogs for NEMP1 Gene

genes like me logo Genes that share paralogs with NEMP1: view

Variants for NEMP1 Gene

Sequence variations from dbSNP and Humsavar for NEMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17546579 - 57,064,176(+) GTAAA(C/T)GGGAC intron-variant, reference, missense
rs7308208 -- 57,060,063(+) ATCTG(A/G)AAAAG intron-variant
rs7312600 -- 57,064,891(+) cagac(A/C)actgc intron-variant
rs7315594 -- 57,064,927(+) taagt(A/C/T)agtca intron-variant
rs2035545 -- 57,083,648(-) ACAGT(A/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEMP1 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for NEMP1 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEMP1 Gene

Disorders for NEMP1 Gene

Relevant External Links for NEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEMP1

No disorders were found for NEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP1 Gene

Publications for NEMP1 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T. … Taira M. (PLoS ONE 2015) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 65
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4 65
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65

Products for NEMP1 Gene

Sources for NEMP1 Gene

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