Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEMP1 Gene

Aliases for NEMP1 Gene

  • Nuclear Envelope Integral Membrane Protein 1 2 3 5
  • Transmembrane Protein 194A 2 3
  • Transmembrane Protein 194 2 3
  • TMEM194A 3 4
  • TMEM194 3 4
  • KIAA0286 4

External Ids for NEMP1 Gene

Previous HGNC Symbols for NEMP1 Gene

  • TMEM194
  • TMEM194A

Summaries for NEMP1 Gene

GeneCards Summary for NEMP1 Gene

NEMP1 (Nuclear Envelope Integral Membrane Protein 1) is a Protein Coding gene. An important paralog of this gene is NEMP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP1 Gene

Genomics for NEMP1 Gene

Regulatory Elements for NEMP1 Gene

Promoters for NEMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEMP1 Gene

57,055,643 bp from pter
57,088,857 bp from pter
33,215 bases
Minus strand

Genomic View for NEMP1 Gene

Genes around NEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP1 Gene

Proteins for NEMP1 Gene

  • Protein details for NEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear envelope integral membrane protein 1
    Protein Accession:
    Secondary Accessions:
    • Q17R72
    • Q68DH0
    • Q6IQ25

    Protein attributes for NEMP1 Gene

    444 amino acids
    Molecular mass:
    50640 Da
    Quaternary structure:
    • Homooligomer. Interacts with RAN-GTP.
    • Sequence=AAH71597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA22955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEMP1 Gene


neXtProt entry for NEMP1 Gene

Proteomics data for NEMP1 Gene at MOPED

Post-translational modifications for NEMP1 Gene

Other Protein References for NEMP1 Gene

No data available for DME Specific Peptides for NEMP1 Gene

Domains & Families for NEMP1 Gene

Protein Domains for NEMP1 Gene


Suggested Antigen Peptide Sequences for NEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP1: view

No data available for Gene Families for NEMP1 Gene

Function for NEMP1 Gene

Gene Ontology (GO) - Molecular Function for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NEMP1: view

Animal Model Products

miRNA for NEMP1 Gene

miRTarBase miRNAs that target NEMP1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEMP1 Gene

Localization for NEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP1 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250 UniProtKB:Q6ZQE4}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEMP1 Gene

Pathways & Interactions for NEMP1 Gene

SuperPathways for NEMP1 Gene

No Data Available

Interacting Proteins for NEMP1 Gene

Gene Ontology (GO) - Biological Process for NEMP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NEMP1 Gene

Drugs & Compounds for NEMP1 Gene

No Compound Related Data Available

Transcripts for NEMP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP1 Gene

No ASD Table

Relevant External Links for NEMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEMP1 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NEMP1 Gene

Orthologs for NEMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia TMEM194A 36
  • 45 (a)
(Monodelphis domestica)
Mammalia TMEM194A 36
  • 77 (a)
(Mus musculus)
Mammalia Tmem194 16
Tmem194 35
  • 85.4 (n)
  • 82.57 (a)
Tmem194 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMEM194A 35
  • 99.77 (n)
  • 99.55 (a)
TMEM194A 36
  • 100 (a)
(Canis familiaris)
Mammalia TMEM194A 35
  • 91.48 (n)
  • 88.58 (a)
TMEM194A 36
  • 81 (a)
(Bos Taurus)
Mammalia TMEM194A 35
  • 89.41 (n)
  • 85.59 (a)
TMEM194A 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Tmem194 35
  • 84.55 (n)
  • 82.88 (a)
(Gallus gallus)
Aves TMEM194A 36
  • 60 (a)
TMEM194A 35
  • 65.84 (n)
  • 63.95 (a)
(Anolis carolinensis)
Reptilia TMEM194A 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3173 35
tmem194a 35
  • 65.81 (n)
  • 64.62 (a)
(Danio rerio)
Actinopterygii tmem194a 35
  • 59.98 (n)
  • 54.76 (a)
tmem194a 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9723 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea F10C5.2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for NEMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEMP1 Gene

Gene Tree for NEMP1 (if available)
Gene Tree for NEMP1 (if available)

Paralogs for NEMP1 Gene

Paralogs for NEMP1 Gene

genes like me logo Genes that share paralogs with NEMP1: view

Variants for NEMP1 Gene

Sequence variations from dbSNP and Humsavar for NEMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17546579 - 57,064,176(+) GTAAA(C/T)GGGAC intron-variant, reference, missense
rs4039 -- 57,055,827(+) AATAT(G/T)TAAAT utr-variant-3-prime
rs364408 -- 57,070,578(+) GGAGC(G/T)GTCTT intron-variant
rs379367 -- 57,069,424(+) AGCCC(A/C)CCTAA intron-variant
rs387513 -- 57,069,441(+) TTTAA(A/T)TTTCA intron-variant

Variation tolerance for NEMP1 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEMP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NEMP1 Gene

Disorders for NEMP1 Gene

Relevant External Links for NEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP1 Gene

Publications for NEMP1 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T. … Taira M. (PLoS ONE 2015) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for NEMP1 Gene

Sources for NEMP1 Gene

Back to Top