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Aliases for NEMP1 Gene

Aliases for NEMP1 Gene

  • Nuclear Envelope Integral Membrane Protein 1 2 3 5
  • Transmembrane Protein 194A 2 3
  • Transmembrane Protein 194 2 3
  • TMEM194A 3 4
  • TMEM194 3 4
  • KIAA0286 4

External Ids for NEMP1 Gene

Previous HGNC Symbols for NEMP1 Gene

  • TMEM194
  • TMEM194A

Summaries for NEMP1 Gene

GeneCards Summary for NEMP1 Gene

NEMP1 (Nuclear Envelope Integral Membrane Protein 1) is a Protein Coding gene. An important paralog of this gene is NEMP2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMP1 Gene

Genomics for NEMP1 Gene

Regulatory Elements for NEMP1 Gene

Enhancers for NEMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057109 1.5 ENCODE dbSUPER 134.8 -22.4 -22397 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MCM3 NEMP1 SMARCC2 ENSG00000257740 ANKRD52 BAZ2A NAB2 ENSG00000224713 CTDSP2 LOC283387 RN7SL809P
GH12G056718 1.5 ENCODE dbSUPER 131.3 +366.3 366299 8.9 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 SMARCC2 BAZ2A ENSG00000257740 ANKRD52 TMEM198B ENSG00000224713 NAB2 RN7SL809P STAT2
GH12G056220 1.4 ENCODE dbSUPER 85.7 +866.0 865976 5.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 PHC1P1 ANKRD52 BAZ2A SMARCC2 STAT2 RN7SL809P ENSG00000257740 RBMS2 NAB2
GH12G056683 1.9 FANTOM5 ENCODE dbSUPER 62.6 +402.1 402086 7.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 BAZ2A NEMP1 ENSG00000258317 ZC3H10 RN7SL809P PA2G4 STAT2 PRIM1 RNU6-343P RBMS2
GH12G056266 1.2 ENCODE 62.1 +821.7 821664 2.0 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NEMP1 PHC1P1 ANKRD52 SMARCC2 BAZ2A RN7SL809P ENSG00000257740 ENSG00000257303 RBMS2 STAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEMP1 on UCSC Golden Path with GeneCards custom track

Promoters for NEMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NEMP1 Gene

57,055,643 bp from pter
57,088,857 bp from pter
33,215 bases
Minus strand

Genomic View for NEMP1 Gene

Genes around NEMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMP1 Gene

Proteins for NEMP1 Gene

  • Protein details for NEMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear envelope integral membrane protein 1
    Protein Accession:
    Secondary Accessions:
    • Q17R72
    • Q68DH0
    • Q6IQ25

    Protein attributes for NEMP1 Gene

    444 amino acids
    Molecular mass:
    50640 Da
    Quaternary structure:
    • Homooligomer. Interacts with RAN-GTP.
    • Sequence=AAH71597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA22955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEMP1 Gene


neXtProt entry for NEMP1 Gene

Post-translational modifications for NEMP1 Gene

  • Phosphorylation may regulate its interaction with RAN-GTP.
  • Ubiquitination at posLast=7575 and Lys375
  • Glycosylation at Asn125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NEMP1 Gene

Domains & Families for NEMP1 Gene

Protein Domains for NEMP1 Gene


Suggested Antigen Peptide Sequences for NEMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
  • The transmembrane domains are required and sufficient for its oligomerization.
  • Belongs to the NEMP family.
genes like me logo Genes that share domains with NEMP1: view

No data available for Gene Families for NEMP1 Gene

Function for NEMP1 Gene

Gene Ontology (GO) - Molecular Function for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NEMP1: view

Phenotypes for NEMP1 Gene

GenomeRNAi human phenotypes for NEMP1:
genes like me logo Genes that share phenotypes with NEMP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEMP1 Gene

Localization for NEMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMP1 Gene

Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side. Nucleus envelope. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000250 UniProtKB:Q6ZQE4}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEMP1 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope ISS --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NEMP1: view

Pathways & Interactions for NEMP1 Gene

SuperPathways for NEMP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NEMP1: view

No data available for Pathways by source and SIGNOR curated interactions for NEMP1 Gene

Drugs & Compounds for NEMP1 Gene

No Compound Related Data Available

Transcripts for NEMP1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMP1 Gene

No ASD Table

Relevant External Links for NEMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEMP1 Gene:


Evidence on tissue expression from TISSUES for NEMP1 Gene

  • Liver(4.1)
  • Nervous system(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEMP1 Gene

Orthologs for NEMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM194A 35 34
  • 99.77 (n)
(Canis familiaris)
Mammalia TMEM194A 34 35
  • 91.48 (n)
(Bos Taurus)
Mammalia TMEM194A 34 35
  • 89.41 (n)
(Mus musculus)
Mammalia Tmem194 35 34
  • 85.4 (n)
Nemp1 16
(Rattus norvegicus)
Mammalia Tmem194 34
  • 84.55 (n)
(Monodelphis domestica)
Mammalia TMEM194A 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM194A 35
  • 45 (a)
(Gallus gallus)
Aves TMEM194A 35 34
  • 65.84 (n)
(Anolis carolinensis)
Reptilia TMEM194A 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem194a 34
  • 65.81 (n)
Str.3173 34
(Danio rerio)
Actinopterygii tmem194a 34 35
  • 59.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9723 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea F10C5.2 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
Species where no ortholog for NEMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEMP1 Gene

Gene Tree for NEMP1 (if available)
Gene Tree for NEMP1 (if available)

Paralogs for NEMP1 Gene

Paralogs for NEMP1 Gene

genes like me logo Genes that share paralogs with NEMP1: view

Variants for NEMP1 Gene

Sequence variations from dbSNP and Humsavar for NEMP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000197083 -- 57,059,173(+) AAAGG(C/T)AAATA utr-variant-3-prime
rs1000224945 -- 57,061,624(+) GGAGG(C/T)GGAGG intron-variant
rs1000231914 -- 57,074,137(+) CTAGT(G/T)TTTTT intron-variant
rs1000287517 -- 57,072,180(+) TGCCT(A/G)TAATC intron-variant
rs1000401430 -- 57,067,465(+) AATAT(G/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEMP1 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv832428 CNV gain 17160897

Variation tolerance for NEMP1 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEMP1 Gene

Disorders for NEMP1 Gene

Relevant External Links for NEMP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMP1 Gene

Publications for NEMP1 Gene

  1. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. (PMID: 25946333) Shibano T. … Taira M. (PLoS ONE 2015) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for NEMP1 Gene

Sources for NEMP1 Gene

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