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Aliases for NEMF Gene

Aliases for NEMF Gene

  • Nuclear Export Mediator Factor 2 3
  • Serologically Defined Colon Cancer Antigen 1 2 3 4
  • SDCCAG1 3 4 6
  • Antigen NY-CO-1 3 4
  • Nuclear Export Mediator Factor NEMF 3
  • NY-CO-1 3

External Ids for NEMF Gene

Previous Symbols for NEMF Gene

  • SDCCAG1

Summaries for NEMF Gene

GeneCards Summary for NEMF Gene

NEMF (Nuclear Export Mediator Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NEMF Gene

  • Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMF Gene

Genomics for NEMF Gene

Genomic Location for NEMF Gene

Start:
49,782,083 bp from pter
End:
49,853,203 bp from pter
Size:
71,121 bases
Orientation:
Minus strand

Genomic View for NEMF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEMF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMF Gene

No data available for Regulatory Elements for NEMF Gene

Proteins for NEMF Gene

  • Protein details for NEMF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60524-NEMF_HUMAN
    Recommended name:
    Nuclear export mediator factor NEMF
    Protein Accession:
    O60524
    Secondary Accessions:
    • A0JLQ3
    • B3KSK1
    • B4DDL3
    • B4DHA9
    • B4E3F3
    • Q32Q66
    • Q8WW70
    • Q9NWG1

    Protein attributes for NEMF Gene

    Size:
    1076 amino acids
    Molecular mass:
    122954 Da
    Quaternary structure:
    • Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF (PubMed:25578875). The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors (By similarity). RQC forms a stable complex with 60S ribosomal subunits (PubMed:25578875). Interacts (via its N-terminus) with XPO1 (By similarity).
    Miscellaneous:
    • Active in normal lung tissue, but is inactive in several lung cancer cell lines
    SequenceCaution:
    • Sequence=AAC18036.1; Type=Frameshift; Positions=1065; Evidence={ECO:0000305}; Sequence=AAH06001.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH20794.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH56687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07765.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Frameshift; Positions=246, 1025; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEMF Gene

    Alternative splice isoforms for NEMF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMF Gene

Proteomics data for NEMF Gene at MOPED

Post-translational modifications for NEMF Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35

Other Protein References for NEMF Gene

No data available for DME Specific Peptides for NEMF Gene

Domains for NEMF Gene

Protein Domains for NEMF Gene

UniProtKB/Swiss-Prot:

NEMF_HUMAN
Domain:
  • The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).:
    • O60524
Family:
  • Belongs to the NEMF family.:
    • O60524
genes like me logo Genes that share domains with NEMF: view

No data available for Gene Families for NEMF Gene

Function for NEMF Gene

Molecular function for NEMF Gene

UniProtKB/Swiss-Prot Function: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).

miRNA for NEMF Gene

miRTarBase miRNAs that target NEMF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NEMF Gene

Localization for NEMF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMF Gene

Gene Ontology (GO) - Cellular Components for NEMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEMF: view

Pathways for NEMF Gene

SuperPathways for NEMF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044780 bacterial-type flagellum assembly --
GO:0051168 nuclear export IMP 16103875
genes like me logo Genes that share ontologies with NEMF: view

No data available for Pathways by source for NEMF Gene

Transcripts for NEMF Gene

Unigene Clusters for NEMF Gene

Nuclear export mediator factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEMF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NEMF Gene

GeneLoc Exon Structure for
NEMF
ECgene alternative splicing isoforms for
NEMF

Expression for NEMF Gene

mRNA expression in normal human tissues for NEMF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEMF Gene

SOURCE GeneReport for Unigene cluster for NEMF Gene Hs.655964

mRNA Expression by UniProt/SwissProt for NEMF Gene

O60524-NEMF_HUMAN
Tissue specificity: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.
genes like me logo Genes that share expressions with NEMF: view

Orthologs for NEMF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NEMF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEMF 36
  • 99.54 (n)
  • 99.72 (a)
NEMF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEMF 36
  • 92.4 (n)
  • 93.58 (a)
NEMF 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEMF 36
  • 93.43 (n)
  • 94.61 (a)
NEMF 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nemf 36
  • 88.57 (n)
  • 90.13 (a)
Nemf 16
Nemf 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEMF 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEMF 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nemf 36
  • 87.82 (n)
  • 89.11 (a)
chicken
(Gallus gallus)
Aves NEMF 36
  • 73.92 (n)
  • 78.05 (a)
NEMF 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nemf 36
  • 70.33 (n)
  • 72.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12972 36
zebrafish
(Danio rerio)
Actinopterygii Dr.10362 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002680 36
  • 51.58 (n)
  • 50.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clbn 36
  • 57.82 (n)
  • 57.3 (a)
Clbn 37
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.18 36
  • 52.92 (n)
  • 46.63 (a)
Y82E9BR.18 37
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE2 37
  • 28 (a)
OneToOne
TAE2 39
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1441 36
  • 51.37 (n)
  • 41.82 (a)
rice
(Oryza sativa)
Liliopsida Os.26814 36
Os12g0564600 36
  • 50.05 (n)
  • 43.29 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8214 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC132.01c 36
  • 48.64 (n)
  • 40.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8376 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for NEMF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NEMF Gene

ENSEMBL:
Gene Tree for NEMF (if available)
TreeFam:
Gene Tree for NEMF (if available)

Paralogs for NEMF Gene

No data available for Paralogs for NEMF Gene

Variants for NEMF Gene

Sequence variations from dbSNP and Humsavar for NEMF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs961056 -- 49,824,939(+) AAAAT(A/T)AAGTA intron-variant
rs1129834 -- 49,789,552(-) TGAAA(A/G)AAAAA missense, reference, nc-transcript-variant
rs1129857 -- 49,795,967(-) GAAAT(G/T)TTTTC intron-variant
rs1129858 -- 49,795,844(-) CTCAT(C/T)AGAAC reference, stop-gained, nc-transcript-variant
rs1869974 -- 49,853,208(-) GTTTC(C/G)TTACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEMF Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv509533 CNV Insertion 20534489

Relevant External Links for NEMF Gene

HapMap Linkage Disequilibrium report
NEMF

Disorders for NEMF Gene

No disorders were found for NEMF Gene.

No data available for UniProtKB/Swiss-Prot for NEMF Gene

Publications for NEMF Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  2. Assignment of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization. (PMID: 10575219) Carbonnelle D. … Roussakis C. (Cytogenet. Cell Genet. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. (PMID: 16103875) Bi X. … Mortin M.A. (Oncogene 2005) 3 4

Products for NEMF Gene

Sources for NEMF Gene

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