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Aliases for NEMF Gene

Aliases for NEMF Gene

  • Nuclear Export Mediator Factor 2 3 5
  • Serologically Defined Colon Cancer Antigen 1 2 3 4
  • Antigen NY-CO-1 3 4
  • SDCCAG1 3 4
  • NY-CO-1 3

External Ids for NEMF Gene

Previous HGNC Symbols for NEMF Gene

  • SDCCAG1

Previous GeneCards Identifiers for NEMF Gene

  • GC14M050250

Summaries for NEMF Gene

GeneCards Summary for NEMF Gene

NEMF (Nuclear Export Mediator Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NEMF Gene

  • Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMF Gene

Genomics for NEMF Gene

Regulatory Elements for NEMF Gene

Enhancers for NEMF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEMF on UCSC Golden Path with GeneCards custom track

Promoters for NEMF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEMF on UCSC Golden Path with GeneCards custom track

Genomic Location for NEMF Gene

Chromosome:
14
Start:
49,782,083 bp from pter
End:
49,853,203 bp from pter
Size:
71,121 bases
Orientation:
Minus strand

Genomic View for NEMF Gene

Genes around NEMF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMF Gene

Proteins for NEMF Gene

  • Protein details for NEMF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60524-NEMF_HUMAN
    Recommended name:
    Nuclear export mediator factor NEMF
    Protein Accession:
    O60524
    Secondary Accessions:
    • A0JLQ3
    • B3KSK1
    • B4DDL3
    • B4DHA9
    • B4E3F3
    • Q32Q66
    • Q8WW70
    • Q9NWG1

    Protein attributes for NEMF Gene

    Size:
    1076 amino acids
    Molecular mass:
    122954 Da
    Quaternary structure:
    • Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF (PubMed:25578875). The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors (By similarity). RQC forms a stable complex with 60S ribosomal subunits (PubMed:25578875). Interacts (via its N-terminus) with XPO1 (By similarity).
    Miscellaneous:
    • Active in normal lung tissue, but is inactive in several lung cancer cell lines.
    SequenceCaution:
    • Sequence=AAC18036.1; Type=Frameshift; Positions=1065; Evidence={ECO:0000305}; Sequence=AAH06001.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH20794.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH56687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07765.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Frameshift; Positions=246, 1025; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEMF Gene

    Alternative splice isoforms for NEMF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMF Gene

Proteomics data for NEMF Gene at MOPED

Post-translational modifications for NEMF Gene

  • Ubiquitination at Lys 35
  • Modification sites at PhosphoSitePlus

Other Protein References for NEMF Gene

No data available for DME Specific Peptides for NEMF Gene

Domains & Families for NEMF Gene

Protein Domains for NEMF Gene

Suggested Antigen Peptide Sequences for NEMF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60524

UniProtKB/Swiss-Prot:

NEMF_HUMAN :
  • The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).
  • Belongs to the NEMF family.
Domain:
  • The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).
Family:
  • Belongs to the NEMF family.
genes like me logo Genes that share domains with NEMF: view

No data available for Gene Families for NEMF Gene

Function for NEMF Gene

Molecular function for NEMF Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).

Phenotypes for NEMF Gene

genes like me logo Genes that share phenotypes with NEMF: view

Animal Models for NEMF Gene

MGI Knock Outs for NEMF:
  • Nemf tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for NEMF Gene

miRTarBase miRNAs that target NEMF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEMF Gene

Localization for NEMF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEMF Gene COMPARTMENTS Subcellular localization image for NEMF gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for NEMF Gene

Pathways & Interactions for NEMF Gene

SuperPathways for NEMF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEMF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEMF Gene

Drugs & Compounds for NEMF Gene

No Compound Related Data Available

Transcripts for NEMF Gene

Unigene Clusters for NEMF Gene

Nuclear export mediator factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEMF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NEMF Gene

GeneLoc Exon Structure for
NEMF
ECgene alternative splicing isoforms for
NEMF

Expression for NEMF Gene

mRNA expression in normal human tissues for NEMF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEMF Gene

This gene is overexpressed in Lung (32.9) and Breast (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEMF Gene



SOURCE GeneReport for Unigene cluster for NEMF Gene Hs.655964

mRNA Expression by UniProt/SwissProt for NEMF Gene

O60524-NEMF_HUMAN
Tissue specificity: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.
genes like me logo Genes that share expression patterns with NEMF: view

Protein tissue co-expression partners for NEMF Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for NEMF Gene

Orthologs for NEMF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NEMF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEMF 35
  • 92.4 (n)
  • 93.58 (a)
NEMF 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEMF 35
  • 93.43 (n)
  • 94.61 (a)
NEMF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nemf 35
  • 88.57 (n)
  • 90.13 (a)
Nemf 16
Nemf 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEMF 35
  • 99.54 (n)
  • 99.72 (a)
NEMF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nemf 35
  • 87.82 (n)
  • 89.11 (a)
oppossum
(Monodelphis domestica)
Mammalia NEMF 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEMF 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEMF 35
  • 73.92 (n)
  • 78.05 (a)
NEMF 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nemf 35
  • 70.33 (n)
  • 72.51 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.10362 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12972 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002680 35
  • 51.58 (n)
  • 50.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Clbn 35
  • 57.82 (n)
  • 57.3 (a)
Clbn 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.18 35
  • 52.92 (n)
  • 46.63 (a)
Y82E9BR.18 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE2 36
  • 28 (a)
OneToOne
RQC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1441 35
  • 51.37 (n)
  • 41.82 (a)
rice
(Oryza sativa)
Liliopsida Os.26814 35
Os12g0564600 35
  • 50.05 (n)
  • 43.29 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.8214 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8376 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC132.01c 35
  • 48.64 (n)
  • 40.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for NEMF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NEMF Gene

ENSEMBL:
Gene Tree for NEMF (if available)
TreeFam:
Gene Tree for NEMF (if available)

Paralogs for NEMF Gene

No data available for Paralogs for NEMF Gene

Variants for NEMF Gene

Sequence variations from dbSNP and Humsavar for NEMF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3100906 - 49,832,244(-) AACCA(A/T)GCTTG nc-transcript-variant, reference, missense
rs7140502 -- 49,819,049(+) TTTTT(A/T)AAAAA intron-variant
rs7492602 -- 49,787,697(+) ccata(A/G)caCCT intron-variant
rs7492655 -- 49,831,446(+) TTTTT(C/T)TTTTT intron-variant
rs7492811 -- 49,831,445(+) TTTTT(C/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEMF Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv509533 CNV Insertion 20534489

Variation tolerance for NEMF Gene

Residual Variation Intolerance Score: 7.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NEMF Gene

Disorders for NEMF Gene

Relevant External Links for NEMF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEMF

No disorders were found for NEMF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMF Gene

Publications for NEMF Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 67
  2. Assignment of the serologically defined colon cancer antigen 1 gene (SDCCAG1) to human chromosome band 14q22 by in situ hybridization. (PMID: 10575219) Carbonnelle D. … Roussakis C. (Cytogenet. Cell Genet. 1999) 2 3
  3. Structure and assembly pathway of the ribosome quality control complex. (PMID: 25578875) Shao S. … Hegde R.S. (Mol. Cell 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for NEMF Gene

Sources for NEMF Gene

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