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Aliases for NEMF Gene

Aliases for NEMF Gene

  • Nuclear Export Mediator Factor 2 3 5
  • Serologically Defined Colon Cancer Antigen 1 2 3 4
  • Antigen NY-CO-1 3 4
  • SDCCAG1 3 4
  • Nuclear Export Mediator Factor NEMF 3
  • NY-CO-1 3

External Ids for NEMF Gene

Previous HGNC Symbols for NEMF Gene

  • SDCCAG1

Previous GeneCards Identifiers for NEMF Gene

  • GC14M050250

Summaries for NEMF Gene

Entrez Gene Summary for NEMF Gene

  • This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEMF Gene

NEMF (Nuclear Export Mediator Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NEMF Gene

  • Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEMF Gene

Genomics for NEMF Gene

Regulatory Elements for NEMF Gene

Enhancers for NEMF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G049830 0.6 ENCODE 12 +22.9 22896 0.1 CTCF PKNOX1 PBX2 TRIM22 SMC3 RAD21 NEMF MGAT2 RPL36AL VCPKMT ENSG00000277634 GC14M049783
GH14G049969 2 FANTOM5 Ensembl ENCODE dbSUPER 3.1 -123.6 -123601 15.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF207 VCPKMT LINC01588 KLHDC1 RNU6-189P RPL36AL ARF6 NEMF DNAAF2 ATP5S RPS29
GH14G049618 1.7 FANTOM5 ENCODE dbSUPER 2.5 +231.0 231018 6.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 RPL36AL LRR1 DNAAF2 RNU6ATAC30P VCPKMT RHOQP1 KLHDC2 NEMF ARF6 RPS29
GH14G050080 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2 -231.9 -231926 8.9 HDGF PKNOX1 WRNIP1 TCF12 ELK1 CBX5 ZNF143 ZNF207 FOS JUNB VCPKMT RNU6-189P DNAAF2 ATL1 ATP5S LINC01588 ARF6 KLHDC2 NEMF SOS2
GH14G049867 2 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -16.0 -15977 3.7 HDGF PKNOX1 SIN3A FEZF1 YY1 SLC30A9 CBX5 ZNF207 ZNF263 SP3 LINC01588 VCPKMT RNU6-189P ARF6 RPL36AL LRR1 SOS2 NEMF MGAT2 LOC105378179
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEMF on UCSC Golden Path with GeneCards custom track

Promoters for NEMF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068047 403 2401 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for NEMF Gene

Chromosome:
14
Start:
49,782,083 bp from pter
End:
49,853,203 bp from pter
Size:
71,121 bases
Orientation:
Minus strand

Genomic View for NEMF Gene

Genes around NEMF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEMF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEMF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEMF Gene

Proteins for NEMF Gene

  • Protein details for NEMF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60524-NEMF_HUMAN
    Recommended name:
    Nuclear export mediator factor NEMF
    Protein Accession:
    O60524
    Secondary Accessions:
    • A0JLQ3
    • B3KSK1
    • B4DDL3
    • B4DHA9
    • B4E3F3
    • Q32Q66
    • Q8WW70
    • Q9NWG1

    Protein attributes for NEMF Gene

    Size:
    1076 amino acids
    Molecular mass:
    122954 Da
    Quaternary structure:
    • Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase LTN1 and NEMF (PubMed:25578875). The complex probably also contains TCF25 as well as VCP/p97 and its ubiquitin-binding cofactors (By similarity). RQC forms a stable complex with 60S ribosomal subunits (PubMed:25578875). Interacts (via its N-terminus) with XPO1 (By similarity).
    Miscellaneous:
    • Active in normal lung tissue, but is inactive in several lung cancer cell lines.
    SequenceCaution:
    • Sequence=AAC18036.1; Type=Frameshift; Positions=1065; Evidence={ECO:0000305}; Sequence=AAH06001.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH20794.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH56687.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07765.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52763.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Frameshift; Positions=246, 1025; Evidence={ECO:0000305}; Sequence=BAG58070.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEMF Gene

    Alternative splice isoforms for NEMF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEMF Gene

Post-translational modifications for NEMF Gene

  • Ubiquitination at Lys35
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NEMF Gene

Domains & Families for NEMF Gene

Protein Domains for NEMF Gene

Suggested Antigen Peptide Sequences for NEMF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60524

UniProtKB/Swiss-Prot:

NEMF_HUMAN :
  • The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).
  • Belongs to the NEMF family.
Domain:
  • The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins (By similarity).
Family:
  • Belongs to the NEMF family.
genes like me logo Genes that share domains with NEMF: view

No data available for Gene Families for NEMF Gene

Function for NEMF Gene

Molecular function for NEMF Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. NEMF is important for the stable association of LTN1 to the complex (PubMed:25578875). May indirectly play a role in nuclear export (PubMed:16103875).
genes like me logo Genes that share phenotypes with NEMF: view

Animal Models for NEMF Gene

MGI Knock Outs for NEMF:
  • Nemf tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for NEMF Gene

miRTarBase miRNAs that target NEMF

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEMF Gene

Localization for NEMF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEMF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEMF gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NEMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NEMF: view

Pathways & Interactions for NEMF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEMF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051168 nuclear export IMP 16103875
genes like me logo Genes that share ontologies with NEMF: view

No data available for Pathways by source and SIGNOR curated interactions for NEMF Gene

Drugs & Compounds for NEMF Gene

No Compound Related Data Available

Transcripts for NEMF Gene

Unigene Clusters for NEMF Gene

Nuclear export mediator factor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEMF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NEMF Gene

GeneLoc Exon Structure for
NEMF
ECgene alternative splicing isoforms for
NEMF

Expression for NEMF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEMF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEMF Gene

This gene is overexpressed in Lung (32.9) and Breast (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEMF Gene



Protein tissue co-expression partners for NEMF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEMF Gene:

NEMF

SOURCE GeneReport for Unigene cluster for NEMF Gene:

Hs.655964

mRNA Expression by UniProt/SwissProt for NEMF Gene:

O60524-NEMF_HUMAN
Tissue specificity: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis.

Evidence on tissue expression from TISSUES for NEMF Gene

  • Nervous system(4.7)
  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with NEMF: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEMF Gene

Orthologs for NEMF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NEMF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEMF 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia NEMF 34 35
  • 93.43 (n)
cow
(Bos Taurus)
Mammalia NEMF 34 35
  • 92.4 (n)
mouse
(Mus musculus)
Mammalia Nemf 34 16 35
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Nemf 34
  • 87.82 (n)
oppossum
(Monodelphis domestica)
Mammalia NEMF 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEMF 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEMF 34 35
  • 73.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nemf 34
  • 70.33 (n)
zebrafish
(Danio rerio)
Actinopterygii Dr.10362 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12972 34
fruit fly
(Drosophila melanogaster)
Insecta Clbn 35 34
  • 57.82 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002680 34
  • 51.58 (n)
worm
(Caenorhabditis elegans)
Secernentea Y82E9BR.18 34 35
  • 52.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE2 35
  • 28 (a)
OneToOne
RQC2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1441 34
  • 51.37 (n)
rice
(Oryza sativa)
Liliopsida Os12g0564600 34
  • 50.05 (n)
Os.26814 34
wheat
(Triticum aestivum)
Liliopsida Ta.8214 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC132.01c 34
  • 48.64 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8376 34
Species where no ortholog for NEMF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NEMF Gene

ENSEMBL:
Gene Tree for NEMF (if available)
TreeFam:
Gene Tree for NEMF (if available)

Paralogs for NEMF Gene

No data available for Paralogs for NEMF Gene

Variants for NEMF Gene

Sequence variations from dbSNP and Humsavar for NEMF Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs864622015 Uncertain significance 49,799,508(-) AATCA(-/CA)GAGCC nc-transcript-variant, reference, frameshift-variant
rs1000166763 -- 49,806,409(+) GCGCC(C/T)GCCAC intron-variant
rs1000198373 -- 49,791,030(+) TCTTA(C/G)CAAGT intron-variant
rs1000226567 -- 49,797,564(+) TGGGA(C/G)GCAGA intron-variant
rs1000348701 -- 49,791,144(+) TCCTG(A/G)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEMF Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv1138299 CNV deletion 24896259
nsv509533 CNV insertion 20534489

Variation tolerance for NEMF Gene

Residual Variation Intolerance Score: 7.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEMF Gene

Human Gene Mutation Database (HGMD)
NEMF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEMF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEMF Gene

Disorders for NEMF Gene

Relevant External Links for NEMF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEMF

No disorders were found for NEMF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEMF Gene

Publications for NEMF Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 64
  2. Structure and assembly pathway of the ribosome quality control complex. (PMID: 25578875) Shao S. … Hegde R.S. (Mol. Cell 2015) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. (PMID: 16103875) Bi X. … Mortin M.A. (Oncogene 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NEMF Gene

Sources for NEMF Gene

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