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NELL2 Gene

protein-coding   GIFtS: 57
GCID: GC12M044981

NEL-Like 2 (Chicken)

(Previous name: nel (chicken)-like 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NEL-Like 2 (Chicken)1 2     Nel (Chicken)-Like 21
Nel-Related Protein 22 3     Neural Epidermal Growth Factor-Like 22
NRP22 3     Protein Kinase C-Binding Protein NELL22
NEL-Like Protein 22 3     

External Ids:    HGNC: 77511   Entrez Gene: 47532   Ensembl: ENSG000001846137   OMIM: 6023205   UniProtKB: Q994353   

Export aliases for NELL2 gene to outside databases

Previous GC identifers: GC12M044801 GC12M044618 GC12M043188 GC12M041929


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NELL2 Gene:
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and
epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the
cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a
secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and
differentiation as well as in oncogenesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for NELL2 Gene:
NELL2 (NEL-like 2 (chicken)) is a protein-coding gene. GO annotations related to this gene include structural molecule activity and calcium ion binding. An important paralog of this gene is FBN1.

Gene Wiki entry for NELL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NELL2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELL2 promoter sequence
   Search Chromatin IP Primers for NELL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NELL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

NELL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M044981:  view genomic region     (about GC identifiers)

Start:
44,902,058 bp from pter      End:
45,315,631 bp from pter
Size:
413,574 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435 (See protein sequence)
Recommended Name: Protein kinase C-binding protein NELL2 precursor  
Size: 816 amino acids; 91346 Da
Subunit: Homotrimer. Binds to PKC beta-1 (By similarity)
Secondary accessions: B7Z2U7 B7Z5Q4 B7Z9J5 B7Z9U3 Q96JS2
Alternative splicing: 4 isoforms:  Q99435-1   Q99435-2   Q99435-3   Q99435-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NELL2: NX_Q99435

Explore proteomics data for NELL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn225, Asn293, Asn298, Asn517, Asn615, Asn635

  • See NELL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138579.1  NP_001138580.1  NP_001138581.1  NP_001138582.1  NP_006150.1  

    ENSEMBL proteins: 
     ENSP00000390680   ENSP00000449332   ENSP00000394612   ENSP00000447927   ENSP00000327988  
     ENSP00000416341   ENSP00000448107   ENSP00000448407   ENSP00000450102   ENSP00000447085  
     ENSP00000447384   ENSP00000448635   ENSP00000449068   ENSP00000446961   ENSP00000378866  

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    Sino Biological Cell Lysate for NELL2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q99435

    ProtoNet protein and cluster: Q99435

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001007 von Willebrand factor
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin


    UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 3 VWFC domains


    Find genes that share domains with NELL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for NELL2:
    chicken nel-like 2 homolog with a wide and weak expression,expressed in adult and fetal brain and hemopoietic
    cells (nucleated peripheral blood cells) but not in B cell at an earlier stage of development,potentially playing
    an oncogenic role in these cells,involved in the growth and differentiation of neural cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16713569
         
    Find genes that share ontologies with NELL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NELL2:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nell2):
     nervous system 

    Find genes that share phenotypes with NELL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nell2tm1Mho for NELL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NELL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NELL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NELL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NELL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NELL2:
    hsa-mir-331-3p (MIRT019236), hsa-mir-335-5p (MIRT017537), hsa-mir-10b-5p (MIRT025587)

    Block miRNA regulation of human, mouse, rat NELL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NELL2 (see all 13):
    hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p
    SwitchGear 3'UTR luciferase reporter plasmidNELL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NELL2
    Predesigned siRNA for gene silencing in human, mouse, rat NELL2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NELL2

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    OriGene ORF clones in mouse, rat for NELL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NELL2 (NM_006159)
    Sino Biological Human cDNA Clone for NELL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NELL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NELL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NELL2_HUMAN, Q99435: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    plasma membrane2
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with NELL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NELL2 (see all 23)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    DHA Signaling
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NELL2
    Interactions:

        Search GeneGlobe Interaction Network for NELL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for NELL2 (Q994351, 2, 3 ENSP000004163414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD91, 3, ENSP000003447824EBI-946274,EBI-946212 I2D: score=2 STRING: ENSP00000344782
    PRKAR1AP106442, 3, ENSP000003514104MINT-8267265 I2D: score=2 STRING: ENSP00000351410
    ATN1P542593, ENSP000003490764I2D: score=2 STRING: ENSP00000349076
    PRKCZQ055133I2D: score=2 
    ATXN7O152653I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----

    Find genes that share ontologies with NELL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NELL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NELL2 gene (5 alternative transcripts): 
    NM_001145107.1  NM_001145108.1  NM_001145109.1  NM_001145110.1  NM_006159.2  

    Unigene Cluster for NELL2:

    NEL-like 2 (chicken)
    Hs.505326  [show with all ESTs]
    Unigene Representative Sequence: NM_001145108
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000429094(uc001rog.2 uc001roh.2 uc010skz.1 uc010sla.1 uc001roj.2)
    ENST00000551601(uc009zkd.2) ENST00000452445 ENST00000549027(uc010slb.1)
    ENST00000333837 ENST00000437801(uc001roi.1) ENST00000547636 ENST00000550139
    ENST00000549668 ENST00000550313 ENST00000547751 ENST00000550462 ENST00000552993
    ENST00000547172 ENST00000553120 ENST00000548826 ENST00000548531 ENST00000546415

    miRNA
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    Block miRNA regulation of human, mouse, rat NELL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NELL2 (see all 13):
    hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p
    SwitchGear 3'UTR luciferase reporter plasmidNELL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NELL2
    Predesigned siRNA for gene silencing in human, mouse, rat NELL2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NELL2 (NM_006159)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NELL2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NELL2
      QuantiTect SYBR Green Assays in human, mouse, rat NELL2
      QuantiFast Probe-based Assays in human, mouse, rat NELL2

    Additional mRNA sequence: 

    AK055385.1 AK056082.1 AK295125.1 AK297521.1 AK299277.1 AK299733.1 AK309825.1 AK315960.1 
    AK316058.1 BC020544.1 D83018.1 D89629.1 

    16 DOTS entries:

    DT.95290089  DT.91748150  DT.116848  DT.91863933  DT.100792632  DT.100792629  DT.95290095  DT.97785449 
    DT.100792625  DT.91748146  DT.121208355  DT.121208392  DT.121208349  DT.121208369  DT.121208381  DT.121208385 

    Selected AceView cDNA sequences (see all 177):

    BQ067510 AU124234 BX478611 BM683119 AL527608 BQ436349 AI206943 AW148817 
    AA976037 BM722137 CR606928 CD677454 AA074208 AL527642 AL536625 AL120292 
    BM471643 BM668754 BG231655 AL535265 F10919 AI962821 AK055385 AA865586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NELL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACTTAAT
    NELL2 Expression
    About this image


    NELL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
    NELL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NELL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505326
        Custom PCR Arrays for NELL2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NELL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NELL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nell21 , 5 NEL-like 2 (chicken)5
    NEL-like 21
    86.37(n)1
    93.65(a)1
      15 (49.39 cM)5
    540031  NM_016743.21  NP_058023.21 
     952194515 
    chicken
    (Gallus gallus)
    Aves NELL21 NEL-like 2 81.37(n)
    87.5(a)
      417799  NM_001030740.1  NP_001025911.1 
    lizard
    (Anolis carolinensis)
    Reptilia NELL26
    NEL-like 2 (chicken)
    86(a)
    1 ↔ 1
    5(54011178-54183402)
    African clawed frog
    (Xenopus laevis)
    Amphibia nell2-prov2 NEL-like 2 (chicken) 78.55(n)    BC044701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nell2b1 NEL-like 2b 67.21(n)
    67.83(a)
      336082  XM_002661379.3  XP_002661425.1 


    ENSEMBL Gene Tree for NELL2 (if available)
    TreeFam Gene Tree for NELL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NELL2 gene
    FBN12  EGFL62  VWCE2  NELL12  NPNT2  FBN22  FBN32  
    18 SIMAP similar genes for NELL2 using alignment to 11 protein entries:     NELL2_HUMAN (see all proteins):
    EMR2    NELL1    CD97    MEGF6    DKFZp686D12108    FBLN7
    FBLN1    UMOD    DKFZp667O055    EFEMP1    LTBP3    NID2
    CRELD1    FBN2    FBN3    FBLN2    ELTD1    SLIT3

    Find genes that share paralogs with NELL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NELL2 (see all 8333)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714359781,2
    C--42021307(+) GGCTA-/ATTT/ 
    ATTTATTT
    ATTTA
    3 -- int11NA 2
    rs30719581,2
    C--44800757(+) acaca-/CACA  
            
    GAGTT
    5 -- int11Minor allele frequency- CACA:0.00NA 2
    rs1401061701,2
    --44901558(+) CTAAGA/CCAGAA 5 -- ds50010--------
    rs1849914101,2
    --44901595(+) CCTGGC/TGAGGC 5 -- ds50010--------
    rs1455180101,2
    --44901646(+) CAGTAA/GGGTGA 5 -- ds50010--------
    rs1885895121,2
    C--44901716(+) TTGACC/TTCTTC 5 -- ds50010--------
    rs1811680911,2
    --44901859(+) TTGAGC/GATCTA 5 -- ds50010--------
    rs1165631101,2
    F--44901931(+) AATTTG/TGAAAT 5 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1837975521,2
    --44901946(+) ACTTTA/CAATTT 5 -- ds50010--------
    rs1880673981,2
    --44901988(+) AGAACC/TAGAAT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for NELL2 (44902058 - 45152058 bp, first 250kb of NELL2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NELL2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745831CNV Deletion23290073
    dgv287e199CNV Deletion23128226
    esv2672049CNV Deletion23128226
    esv1004421CNV Deletion20482838
    esv2745832CNV Deletion23290073
    esv2745835CNV Deletion23290073
    esv2745833CNV Deletion23290073
    esv1923023CNV Deletion18987734
    esv2745834CNV Deletion23290073
    esv2457498CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602320    OMIM disorders: --


    Find genes that share disorders with NELL2           About GenesLikeMe

    Genetic Association Database (GAD): NELL2
    Human Genome Epidemiology (HuGE) Navigator: NELL2 (1 document)

    Export disorders for NELL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NELL2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NELL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. In vitro guidance of retinal axons by a tectal lamina-specific glycoprotein Nel. (PubMed id 19249368)1, 3 Jiang Y....Nakamoto M. (Mol. Cell. Neurosci. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. (PubMed id 8975702)1, 2 Watanabe T.K.... Takahashi E. (Genomics 1996)
    7. The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. (PubMed id 10231576)1, 9 Luce M.J. and Burrows P.D. (Gene 1999)
    8. The E2F1 oncogene transcriptionally regulates NELL2 in cancer cells. (PubMed id 23829315)1 Kim D.H....Leem S.H. (DNA Cell Biol. 2013)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4753 HGNC: 7751 AceView: NELL2 Ensembl:ENSG00000184613 euGenes: HUgn4753
    ECgene: NELL2 H-InvDB: NELL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NELL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NELL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NELL2 gene:
    Search GeneIP for patents involving NELL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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