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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NELL2 Gene

protein-coding GIFtS: 56
GCID: GC12M044981

NEL-like 2 (chicken)

(Previous name: nel (chicken)-like 2 )

Explore 12 diseases affiliated with
NELL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NEL-Like 2 (Chicken)¹ ²		Nel (Chicken)-Like 2¹
NRP2¹ ² ³		Neural Epidermal Growth Factor-Like 2²
Nel-Related Protein 2² ³		Protein Kinase C-Binding Protein NELL2²
NEL-Like Protein 2² ³

External Ids:	HGNC: 7751¹	Entrez Gene: 4753²	Ensembl: ENSG00000184613⁷	OMIM: 602320⁵	UniProtKB: Q99435³

Export aliases for NELL2 gene to outside databases

Previous GC identifers: GC12M044801 GC12M044618 GC12M043188 GC12M041929

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NELL2:

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal

growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several

variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies

in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis.

(provided by RefSeq, Feb 2009)

Gene Wiki entry for NELL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NELL2 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NELL2 promoter sequence

Search SABiosciences Chromatin IP Primers for NELL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NELL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12

NELL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELL2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M044981: view genomic region (about GC identifiers)

Start:	44,902,058 bp from pter	End:	45,315,631 bp from pter
Size:	413,574 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435 (See protein sequence)

Recommended Name: Protein kinase C-binding protein NELL2 precursor

Size: 816 amino acids; 91346 Da

Subunit: Homotrimer. Binds to PKC beta-1 (By similarity)

Subcellular location: Secreted (By similarity)

Secondary accessions: B7Z2U7 B7Z5Q4 B7Z9J5 B7Z9U3 Q96JS2

Alternative splicing: 4 isoforms: Q99435-1 Q99435-2 Q99435-3 Q99435-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NELL2: NX_Q99435

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99435

NELL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001138579.1 NP_001138580.1 NP_001138581.1 NP_001138582.1 NP_006150.1

ENSEMBL proteins:

ENSP00000390680 ENSP00000449332 ENSP00000394612 ENSP00000447927 ENSP00000327988

ENSP00000416341 ENSP00000448107 ENSP00000448407 ENSP00000450102 ENSP00000447085

ENSP00000447384 ENSP00000448635 ENSP00000449068 ENSP00000446961 ENSP00000378866

Human Recombinant Protein Products for NELL2:

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	Novus Biologicals NELL2 Protein Novus Biologicals NELL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NELL2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--

NELL2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NELL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NELL2 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry Q99435

ProtoNet protein and cluster: Q99435

5 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001007 von Willebrand factor

IPB001791 Laminin G

IPB001881 EGF-like calcium-binding

IPB003129 Thrombospondin

UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435

Similarity: Contains 6 EGF-like domains

Similarity: Contains 1 laminin G-like domain

Similarity: Contains 3 VWFC domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for NELL2:

chicken nel-like 2 homolog with a wide and weak expression,expressed in adult and fetal brain and hemopoietic cells

(nucleated peripheral blood cells) but not in B cell at an earlier stage of development,potentially playing an

oncogenic role in these cells,involved in the growth and differentiation of neural cells

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	NAS	--
GO:0005509	calcium ion binding	NAS	--
GO:0005515	protein binding	IPI	16713569

NELL2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NELL2:

Decreased POU5F1-GFP protein e

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nell2):

nervous system

NELL2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Nell2^tm1Mho for NELL2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NELL2

miRNA Products:		OriGene 3'-UTR Clone (see all 5): NELL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NELL2
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NELL2 (see all 13):
		hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NELL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NELL2 (see all 7) OriGene shRNA RFP: NELL2 OriGene siRNA: NELL2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELL2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NELL2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/7 Interacting proteins for NELL2 (Q99435^{1, 2, 3} ENSP00000416341⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GFI1B	Q5VTD9¹^,³, ENSP00000344782⁴	EBI-2845314,EBI-946212 I2D: score=2 STRING: ENSP00000344782
PRKAR1A	P10644²^,³, ENSP00000351410⁴	MINT-8267265 I2D: score=2 STRING: ENSP00000351410
ATN1	P54259³, ENSP00000349076⁴	I2D: score=2 STRING: ENSP00000349076
PRKCZ	Q05513³	I2D: score=2
ATXN7	O15265³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	--
GO:0040008	regulation of growth	--	--

NELL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NELL2
Search CenterWatch for drugs/clinical trials and news about NELL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NELL2 gene (5 alternative transcripts):

NM_001145107.1 NM_001145108.1 NM_001145109.1 NM_001145110.1 NM_006159.2

Unigene Cluster for NELL2:

NEL-like 2 (chicken)

Hs.505326 [show with all ESTs]

Unigene Representative Sequence: NM_001145108

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000429094(uc001rog.2 uc001roh.2 uc010skz.1 uc010sla.1 uc001roj.2)

ENST00000551601(uc009zkd.2) ENST00000452445 ENST00000549027(uc010slb.1)

ENST00000333837 ENST00000437801(uc001roi.1) ENST00000547636 ENST00000550139

ENST00000549668 ENST00000550313 ENST00000547751 ENST00000550462 ENST00000552993

ENST00000547172 ENST00000553120 ENST00000548826 ENST00000548531 ENST00000546415

miRNA Products:		OriGene 3'-UTR Clone (see all 5): NELL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NELL2
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NELL2 (see all 13):
		hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NELL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NELL2

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Additional cDNA sequence:

AK055385.1 AK056082.1 AK295125.1 AK297521.1 AK299277.1 AK299733.1 AK309825.1 AK315960.1

AK316058.1 BC020544.1 D83018.1 D89629.1

16 DOTS entries:

DT.95290089 DT.91748150 DT.116848 DT.91863933 DT.100792632 DT.100792629 DT.95290095 DT.97785449

DT.100792625 DT.91748146 DT.121208355 DT.121208392 DT.121208349 DT.121208369 DT.121208381 DT.121208385

24/177 AceView cDNA sequences (see all 177):

BM722137 AI206943 BQ436349 AA976037 AW148817 AA074208 AL527642 CD677454

AA903786 AA682931 BM722547 D89629 AU131863 BF953620 BF953610 AU129307

BM967112 BI914297 BX279961 BI964863 AA865586 AI141954 AI686682 F10919

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NELL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTACTTAAT

About this image

NELL2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Eye

Kidney

Diencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Spinal Dorsal Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See NELL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NELL2

SOURCE GeneReport for Unigene cluster: Hs.505326

SABiosciences Custom PCR Arrays for NELL2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NELL2 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nell2^{1 , 5}	NEL-like 2 (chicken)⁵ NEL-like 2¹	86.37(n)¹ 93.65(a)¹		15 (49.39 cM)⁵ 54003¹ NM_016743.2¹ NP_058023.2¹ 95219451⁵
chicken (Gallus gallus)	Aves	NELL2¹	NEL-like 2 (chicken)	81.37(n) 87.5(a)		417799 NM_001030740.1 NP_001025911.1
lizard (Anolis carolinensis)	Reptilia	NELL2⁶	--	88(a)	1 ↔ 1	5(54037926-54179359)
African clawed frog (Xenopus laevis)	Amphibia	nell2-prov²	NEL-like 2 (chicken)	78.55(n)		BC044701.1
zebrafish (Danio rerio)	Actinopterygii	nell2b¹	NEL-like 2b	67.21(n) 67.83(a)		336082 XM_002661379.2 XP_002661425.1
honey bee (Apis mellifera)	Insecta	--	--	31(a)	1 → many	GroupUn.17(71119-91844)

ENSEMBL Gene Tree for NELL2 (if available)
TreeFam Gene Tree for NELL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NELL2 gene

NELL1²

18/21 SIMAP similar genes for NELL2 using alignment to 11 protein entries: NELL2_HUMAN (see all proteins) (see all similar genes):

EMR2 NELL1 CD97 MEGF6 DKFZp686D12108 FBLN7

FBLN1 UMOD DKFZp667O055 EFEMP1 LTBP3 NID2

FBN3 CRELD1 FBN2 FBLN2 ELTD1 SLIT3

NELL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140106170^1,2		--	44901558(+)	`CTAAGA/CCAGAA`	5	--	ds500¹		0	--	--	--	--
rs184991410^1,2		--	44901595(+)	`CCTGGC/TGAGGC`	5	--	ds500¹		0	--	--	--	--
rs145518010^1,2		--	44901646(+)	`CAGTAA/GGGTGA`	5	--	ds500¹		0	--	--	--	--
rs188589512^1,2		--	44901716(+)	`TTGACC/TTCTTC`	5	--	ds500¹		0	--	--	--	--
rs181168091^1,2		--	44901859(+)	`TTGAGC/GATCTA`	5	--	ds500¹		0	--	--	--	--
rs116563110^1,2	F	--	44901931(+)	`AATTTG/TGAAAT`	5	--	ds500¹		1		WA	118
rs183797552^1,2		--	44901946(+)	`ACTTTA/CAATTT`	5	--	ds500¹		0	--	--	--	--
rs188067398^1,2		--	44901988(+)	`AGAACC/TAGAAT`	5	--	ds500¹		0	--	--	--	--
rs7302676^1,2	C,F,A,H	--	44902264(+)	`GTACAT/CAACAT`	5	--	ut3¹ ese³		23		NA NS EA WA CSA	2386
rs182254891^1,2		--	44902374(+)	`ATCTAC/GAGGAA`	5	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NELL2 (44902058 - 45152058 bp, first 250kb of NELL2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for NELL2
4 CNVs: 86351 101503 86352 101502
1 Indel: 45053

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NELL2

DNA2.0 Custom Variant and Variant Library Synthesis for NELL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NELL2 for disorders           About GeneDecksing

OMIM gene information: 602320    OMIM disorders: --

12 diseases for NELL2:    About MalaCards

allergic contact dermatitis contact dermatitis central neurocytoma atopic dermatitis

macular degeneration dermatitis psoriasis ataxia

neuroblastoma retinitis prostatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: NELL2 (1 document)

Export disorders for NELL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NELL2 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NELL2)

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In vitro guidance of retinal axons by a tectal lamina -specific glycoprotein Nel. (PubMed id 19249368)^{1, 3} Jiang Y....Nakamoto M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. (PubMed id 8975702)^{1, 2} Watanabe T.K.... Takahashi E. (1996)
The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. (PubMed id 10231576)^{1, 9} Luce M.J. and Burrows P.D. (1999)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4753	HGNC: 7751	AceView: NELL2	Ensembl:ENSG00000184613	euGenes: HUgn4753
ECgene: NELL2	H-InvDB: NELL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NELL2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NELL2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NELL2 gene
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Patent Information for NELL2 gene:
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