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Aliases for NELL2 Gene

Aliases for NELL2 Gene

  • Neural EGFL Like 2 2 3 5
  • NEL-Like Protein 2 3 4
  • NRP2 3 4
  • Neural Epidermal Growth Factor-Like 2 3
  • NEL-Related Protein 2 3
  • Nel-Related Protein 2 4
  • Nel (Chicken)-Like 2 2
  • NEL-Like 2 (Chicken) 2

External Ids for NELL2 Gene

Previous GeneCards Identifiers for NELL2 Gene

  • GC12M044981
  • GC12M044801
  • GC12M044618
  • GC12M043188
  • GC12M041929

Summaries for NELL2 Gene

Entrez Gene Summary for NELL2 Gene

  • The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

GeneCards Summary for NELL2 Gene

NELL2 (Neural EGFL Like 2) is a Protein Coding gene. Diseases associated with NELL2 include Tuberculous Meningitis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NELL1.

UniProtKB/Swiss-Prot for NELL2 Gene

  • Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).

Gene Wiki entry for NELL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NELL2 Gene

Genomics for NELL2 Gene

Regulatory Elements for NELL2 Gene

Enhancers for NELL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NELL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NELL2 gene promoter:

Genomic Location for NELL2 Gene

44,508,275 bp from pter
44,921,848 bp from pter
413,574 bases
Minus strand

Genomic View for NELL2 Gene

Genes around NELL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NELL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NELL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NELL2 Gene

Proteins for NELL2 Gene

  • Protein details for NELL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein kinase C-binding protein NELL2
    Protein Accession:
    Secondary Accessions:
    • B7Z2U7
    • B7Z5Q4
    • B7Z9J5
    • B7Z9U3
    • Q96JS2

    Protein attributes for NELL2 Gene

    816 amino acids
    Molecular mass:
    91346 Da
    Quaternary structure:
    • Homotrimer. Binds to PKC beta-1 (By similarity).

    Alternative splice isoforms for NELL2 Gene


neXtProt entry for NELL2 Gene

Proteomics data for NELL2 Gene at MOPED

Post-translational modifications for NELL2 Gene

  • Glycosylation at Asn 53, Asn 225, Asn 293, Asn 298, Asn 517, Asn 615, and Asn 635
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NELL2

No data available for DME Specific Peptides for NELL2 Gene

Domains & Families for NELL2 Gene

Suggested Antigen Peptide Sequences for NELL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EGF-like domains.
  • Contains 6 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 3 VWFC domains.
genes like me logo Genes that share domains with NELL2: view

No data available for Gene Families for NELL2 Gene

Function for NELL2 Gene

Molecular function for NELL2 Gene

GENATLAS Biochemistry:
chicken nel-like 2 homolog with a wide and weak expression,expressed in adult and fetal brain and hemopoietic cells (nucleated peripheral blood cells) but not in B cell at an earlier stage of development,potentially playing an oncogenic role in these cells,involved in the growth and differentiation of neural cells
UniProtKB/Swiss-Prot Function:
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).
genes like me logo Genes that share phenotypes with NELL2: view

Animal Models for NELL2 Gene

MGI Knock Outs for NELL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NELL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NELL2 Gene

Localization for NELL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NELL2 Gene


Subcellular locations from

Jensen Localization Image for NELL2 Gene COMPARTMENTS Subcellular localization image for NELL2 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NELL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with NELL2: view

Pathways & Interactions for NELL2 Gene

SuperPathways for NELL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NELL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NELL2 Gene

Drugs & Compounds for NELL2 Gene

No Compound Related Data Available

Transcripts for NELL2 Gene

Unigene Clusters for NELL2 Gene

NEL-like 2 (chicken):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NELL2 Gene

No ASD Table

Relevant External Links for NELL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NELL2 Gene

mRNA expression in normal human tissues for NELL2 Gene

mRNA differential expression in normal tissues according to GTEx for NELL2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.5), Brain - Cortex (x7.2), Brain - Anterior cingulate cortex (BA24) (x7.1), and Brain - Hippocampus (x6.1).

Protein differential expression in normal tissues from HIPED for NELL2 Gene

This gene is overexpressed in Cerebrospinal fluid (59.1) and Vitreous humor (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NELL2 Gene

SOURCE GeneReport for Unigene cluster for NELL2 Gene Hs.505326

genes like me logo Genes that share expression patterns with NELL2: view

Protein tissue co-expression partners for NELL2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NELL2 Gene

Orthologs for NELL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NELL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NELL2 35
  • 92.69 (n)
  • 98.16 (a)
NELL2 36
  • 98 (a)
(Canis familiaris)
Mammalia NELL2 35
  • 94 (n)
  • 98.16 (a)
NELL2 36
  • 98 (a)
(Mus musculus)
Mammalia Nell2 35
  • 86.37 (n)
  • 93.65 (a)
Nell2 16
Nell2 36
  • 94 (a)
(Pan troglodytes)
Mammalia NELL2 35
  • 97.2 (n)
  • 96.59 (a)
NELL2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Nell2 35
  • 85.92 (n)
  • 93.65 (a)
(Monodelphis domestica)
Mammalia NELL2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves NELL2 35
  • 81.37 (n)
  • 87.5 (a)
NELL2 36
  • 89 (a)
(Anolis carolinensis)
Reptilia NELL2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nell2 35
  • 77.64 (n)
  • 80.89 (a)
Str.15716 35
African clawed frog
(Xenopus laevis)
Amphibia nell2-prov 35
(Danio rerio)
Actinopterygii nell2b 35
  • 67.21 (n)
  • 67.83 (a)
  • 54 (a)
nell2b 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11077 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for NELL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NELL2 Gene

Gene Tree for NELL2 (if available)
Gene Tree for NELL2 (if available)

Paralogs for NELL2 Gene

Paralogs for NELL2 Gene

genes like me logo Genes that share paralogs with NELL2: view

Variants for NELL2 Gene

Sequence variations from dbSNP and Humsavar for NELL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2658973 - 44,875,857(+) TAAGA(C/T)CCGAG upstream-variant-2KB, reference, missense
rs17574839 - 44,714,697(+) TGTAT(C/T)TCTTT reference, missense
rs1050710 - 44,523,397(+) ATGTC(A/C/G/T)TCATG reference, missense
rs1921550 -- 44,867,560(+) aaaat(A/C)aggaa intron-variant
rs1947265 -- 44,805,978(+) TTCTT(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NELL2 Gene

Variant ID Type Subtype PubMed ID
esv2457498 CNV Deletion 19546169
esv1923023 CNV Deletion 18987734
esv2672049 CNV Deletion 23128226
esv2745831 CNV Deletion 23290073
esv2604257 CNV Insertion 19546169
esv272578 CNV Insertion 20981092
esv270896 CNV Insertion 20981092
esv1571217 CNV Insertion 17803354
nsv832394 CNV Loss 17160897
nsv526438 CNV Loss 19592680
nsv687 CNV Insertion 18451855
dgv287e199 CNV Deletion 23128226
esv273700 CNV Insertion 20981092
esv267624 CNV Insertion 20981092
esv2745832 CNV Deletion 23290073
esv2745833 CNV Deletion 23290073
esv2745834 CNV Deletion 23290073
esv1004421 CNV Deletion 20482838
esv2745835 CNV Deletion 23290073
dgv288e199 CNV Deletion 23128226
dgv1420n71 CNV Loss 21882294
nsv899050 CNV Loss 21882294

Variation tolerance for NELL2 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NELL2 Gene

Disorders for NELL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NELL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
tuberculous meningitis
  • tb meningitis
- elite association - COSMIC cancer census association via MalaCards
Search NELL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NELL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NELL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NELL2 Gene

Publications for NELL2 Gene

  1. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. (PMID: 8975702) Watanabe T.K. … Takahashi E. (Genomics 1996) 2 3 4 67
  2. NELL2 function in the protection of cells against endoplasmic reticulum stress. (PMID: 25537860) Kim D.Y. … Lee B.J. (Mol. Cells 2015) 2 3
  3. The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. (PMID: 10231576) Luce M.J. … Burrows P.D. (Gene 1999) 3 23
  4. Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma. (PMID: 25726761) Nakamura R. … Ooi A. (Cancer Sci. 2015) 3
  5. iTRAQ-based quantitative proteomic analysis of cerebrospinal fluid reveals NELL2 as a potential diagnostic biomarker of tuberculous meningitis. (PMID: 25760060) Yang Y. … Xie P. (Int. J. Mol. Med. 2015) 3

Products for NELL2 Gene

Sources for NELL2 Gene