Aliases for NELL2 Gene
External Ids for NELL2 Gene
Previous GeneCards Identifiers for NELL2 Gene
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]
GeneCards Summary for NELL2 Gene
NELL2 (Neural EGFL Like 2) is a Protein Coding gene. Diseases associated with NELL2 include tuberculous meningitis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NELL1.
UniProtKB/Swiss-Prot for NELL2 Gene
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).