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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NELL2 Gene

protein-coding   GIFtS: 57
GCID: GC12M044981

NEL-Like 2 (Chicken)

(Previous name: nel (chicken)-like 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NEL-Like 2 (Chicken)1 2     Nel (Chicken)-Like 21
Nel-Related Protein 22 3     Neural Epidermal Growth Factor-Like 22
NRP22 3     Protein Kinase C-Binding Protein NELL22
NEL-Like Protein 22 3     

External Ids:    HGNC: 77511   Entrez Gene: 47532   Ensembl: ENSG000001846137   OMIM: 6023205   UniProtKB: Q994353   

Export aliases for NELL2 gene to outside databases

Previous GC identifers: GC12M044801 GC12M044618 GC12M043188 GC12M041929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NELL2 Gene:
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and
epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the
cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a
secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and
differentiation as well as in oncogenesis. (provided by RefSeq, Feb 2009)

GeneCards Summary for NELL2 Gene: 
NELL2 (NEL-like 2 (chicken)) is a protein-coding gene. Diseases associated with NELL2 include central neurocytoma, and contact dermatitis. GO annotations related to this gene include structural molecule activity and calcium ion binding. An important paralog of this gene is NELL1.

Gene Wiki entry for NELL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NELL2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NELL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NELL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

NELL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M044981:  view genomic region     (about GC identifiers)

Start:
44,902,058 bp from pter      End:
45,315,631 bp from pter
Size:
413,574 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435 (See protein sequence)
Recommended Name: Protein kinase C-binding protein NELL2 precursor  
Size: 816 amino acids; 91346 Da
Subunit: Homotrimer. Binds to PKC beta-1 (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: B7Z2U7 B7Z5Q4 B7Z9J5 B7Z9U3 Q96JS2
Alternative splicing: 4 isoforms:  Q99435-1   Q99435-2   Q99435-3   Q99435-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NELL2: NX_Q99435

Explore proteomics data for NELL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99435

  • NELL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NELL2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001138579.1  NP_001138580.1  NP_001138581.1  NP_001138582.1  NP_006150.1  

    ENSEMBL proteins: 
     ENSP00000390680   ENSP00000449332   ENSP00000394612   ENSP00000447927   ENSP00000327988  
     ENSP00000416341   ENSP00000448107   ENSP00000448407   ENSP00000450102   ENSP00000447085  
     ENSP00000447384   ENSP00000448635   ENSP00000449068   ENSP00000446961   ENSP00000378866  

    Human Recombinant Protein Products for NELL2: 
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    Novus Biologicals NELL2 Protein
    Novus Biologicals NELL2 Lysates
    Sino Biological Recombinant Protein for NELL2
    Sino Biological Cell Lysate for NELL2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NELL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--

    NELL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for NELL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR026823 cEGF
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q99435

    ProtoNet protein and cluster: Q99435

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001007 von Willebrand factor
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin


    UniProtKB/Swiss-Prot: NELL2_HUMAN, Q99435
    Similarity: Contains 6 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 3 VWFC domains


    NELL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for NELL2:
    chicken nel-like 2 homolog with a wide and weak expression,expressed in adult and fetal brain and hemopoietic
    cells (nucleated peripheral blood cells) but not in B cell at an earlier stage of development,potentially playing
    an oncogenic role in these cells,involved in the growth and differentiation of neural cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS--
    GO:0005509calcium ion binding NAS--
    GO:0005515protein binding IPI16713569
         
    NELL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NELL2:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nell2):
     nervous system 

    NELL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nell2tm1Mho for NELL2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NELL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NELL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NELL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NELL2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NELL2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NELL2 (see all 13):
    hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p
    SwitchGear 3'UTR luciferase reporter plasmidNELL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NELL2
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    Gene Editing
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    Sino Biological Human cDNA Clone for NELL2
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                         Customized lentivirus expression plasmids for stable overexpression of NELL2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NELL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for NELL2 (Q994351, 2, 3 ENSP000004163414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD91, 3, ENSP000003447824EBI-946274,EBI-946212 I2D: score=2 STRING: ENSP00000344782
    PRKAR1AP106442, 3, ENSP000003514104MINT-8267265 I2D: score=2 STRING: ENSP00000351410
    ATN1P542593, ENSP000003490764I2D: score=2 STRING: ENSP00000349076
    PRKCZQ055133I2D: score=2 
    ATXN7O152653I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS--

    NELL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NELL2

    Search CenterWatch for drugs/clinical trials and news about NELL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NELL2 gene (5 alternative transcripts): 
    NM_001145107.1  NM_001145108.1  NM_001145109.1  NM_001145110.1  NM_006159.2  

    Unigene Cluster for NELL2:

    NEL-like 2 (chicken)
    Hs.505326  [show with all ESTs]
    Unigene Representative Sequence: NM_001145108
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000429094(uc001rog.2 uc001roh.2 uc010skz.1 uc010sla.1 uc001roj.2)
    ENST00000551601(uc009zkd.2) ENST00000452445 ENST00000549027(uc010slb.1)
    ENST00000333837 ENST00000437801(uc001roi.1) ENST00000547636 ENST00000550139
    ENST00000549668 ENST00000550313 ENST00000547751 ENST00000550462 ENST00000552993
    ENST00000547172 ENST00000553120 ENST00000548826 ENST00000548531 ENST00000546415

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NELL2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NELL2 (see all 13):
    hsa-miR-539 hsa-miR-7-2* hsa-miR-519c-3p hsa-miR-507 hsa-miR-519a hsa-miR-21 hsa-miR-519b-3p hsa-miR-590-5p
    SwitchGear 3'UTR luciferase reporter plasmidNELL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NELL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NELL2
    Clone
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    OriGene clones in human, mouse for NELL2 (see all 23)
    OriGene ORF clones in mouse, rat for NELL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NELL2 (NM_006159)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NELL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NELL2
    Sirion Biotech Customized lentivirus for stable overexpression of NELL2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NELL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NELL2

    Additional mRNA sequence: 

    AK055385.1 AK056082.1 AK295125.1 AK297521.1 AK299277.1 AK299733.1 AK309825.1 AK315960.1 
    AK316058.1 BC020544.1 D83018.1 D89629.1 

    16 DOTS entries:

    DT.95290089  DT.91748150  DT.116848  DT.91863933  DT.100792632  DT.100792629  DT.95290095  DT.97785449 
    DT.100792625  DT.91748146  DT.121208355  DT.121208392  DT.121208349  DT.121208369  DT.121208381  DT.121208385 

    24/177 AceView cDNA sequences (see all 177):

    BQ067510 AU124234 BX478611 BM683119 AL527608 BQ436349 AI206943 AW148817 
    AA976037 BM722137 CR606928 CD677454 AA074208 AL527642 AL536625 AL120292 
    BM471643 BM668754 BG231655 AL535265 F10919 AI962821 AK055385 AA865586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NELL2 expression in normal human tissues (normalized intensities)      NELL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTACTTAAT
    NELL2 Expression
    About this image


    NELL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             Line H9 (WA09)
             ESI-049   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain/lateral wall   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             Peripheral blood Pan-T Cells   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   

    See NELL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NELL2

    SOURCE GeneReport for Unigene cluster: Hs.505326
        SABiosciences Custom PCR Arrays for NELL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NELL2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nell21 , 5 NEL-like 2 (chicken)5
    NEL-like 21
    86.37(n)1
    93.65(a)1
      15 (49.39 cM)5
    540031  NM_016743.21  NP_058023.21 
     952194515 
    chicken
    (Gallus gallus)
    Aves NELL21 NEL-like 2 (chicken) 81.37(n)
    87.5(a)
      417799  NM_001030740.1  NP_001025911.1 
    lizard
    (Anolis carolinensis)
    Reptilia NELL26
    NEL-like 2 (chicken)
    86(a)
    1 ↔ 1
    5(54011178-54183402)
    African clawed frog
    (Xenopus laevis)
    Amphibia nell2-prov2 NEL-like 2 (chicken) 78.55(n)    BC044701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nell2b1 NEL-like 2b 67.21(n)
    67.83(a)
      336082  XM_002661379.2  XP_002661425.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F19C6.36
    Protein F19C6.3
    20(a)
    1 → many
    X(10005876-10008755)


    ENSEMBL Gene Tree for NELL2 (if available)
    TreeFam Gene Tree for NELL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NELL2 gene
    NELL12  
    18 SIMAP similar genes for NELL2 using alignment to 11 protein entries:     NELL2_HUMAN (see all proteins):
    EMR2    NELL1    CD97    MEGF6    DKFZp686D12108    FBLN7
    FBLN1    UMOD    DKFZp667O055    EFEMP1    LTBP3    NID2
    CRELD1    FBN2    FBN3    FBLN2    ELTD1    SLIT3

    NELL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8333 SNPs in NELL2 are shown (see all 8333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714359781,2
    C--42021307(+) GGCTA-/ATTT/ 
    ATTTATTT
    ATTTA
    3 -- int11NA 2
    rs30719581,2
    C--44800757(+) acaca-/CACA  
            
    GAGTT
    5 -- int11Minor allele frequency- CACA:0.00NA 2
    rs1401061701,2
    --44901558(+) CTAAGA/CCAGAA 5 -- ds50010--------
    rs1849914101,2
    --44901595(+) CCTGGC/TGAGGC 5 -- ds50010--------
    rs1455180101,2
    --44901646(+) CAGTAA/GGGTGA 5 -- ds50010--------
    rs1885895121,2
    C--44901716(+) TTGACC/TTCTTC 5 -- ds50010--------
    rs1811680911,2
    --44901859(+) TTGAGC/GATCTA 5 -- ds50010--------
    rs1165631101,2
    F--44901931(+) AATTTG/TGAAAT 5 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1837975521,2
    --44901946(+) ACTTTA/CAATTT 5 -- ds50010--------
    rs1880673981,2
    --44901988(+) AGAACC/TAGAAT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for NELL2 (44902058 - 45152058 bp, first 250kb of NELL2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for NELL2 (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745831CNV Deletion23290073
    dgv287e199CNV Deletion23128226
    esv2672049CNV Deletion23128226
    esv1004421CNV Deletion20482838
    esv2745832CNV Deletion23290073
    esv2745835CNV Deletion23290073
    esv2745833CNV Deletion23290073
    esv1923023CNV Deletion18987734
    esv2745834CNV Deletion23290073
    esv2457498CNV Deletion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602320    OMIM disorders: --

    12 diseases for NELL2:    About MalaCards
    central neurocytoma    contact dermatitis    allergic contact dermatitis    dermatitis
    macular degeneration    atopic dermatitis    psoriasis    ataxia
    neuroblastoma    retinitis    prostatitis    neuronitis


    NELL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NELL2
    Human Genome Epidemiology (HuGE) Navigator: NELL2 (1 document)

    Export disorders for NELL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NELL2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NELL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. In vitro guidance of retinal axons by a tectal lamina -specific glycoprotein Nel. (PubMed id 19249368)1, 3 Jiang Y....Nakamoto M. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats. (PubMed id 8975702)1, 2 Watanabe T.K.... Takahashi E. (1996)
    7. The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage. (PubMed id 10231576)1, 9 Luce M.J. and Burrows P.D. (1999)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4753 HGNC: 7751 AceView: NELL2 Ensembl:ENSG00000184613 euGenes: HUgn4753
    ECgene: NELL2 H-InvDB: NELL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NELL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NELL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NELL2 gene:
    Search GeneIP for patents involving NELL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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