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NELFE Gene

protein-coding   GIFtS: 49
GCID: GC06M031926

Negative Elongation Factor Complex Member E

(Previous names: RD RNA-binding protein, RD RNA binding protein)
(Previous symbol: RDBP)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Negative Elongation Factor Complex Member E1 2     D6S452
RDBP1 2 3 5     RDP2
RD RNA Binding Protein1 2     Major Histocompatibility Complex Gene RD2
RD RNA-Binding Protein1 2     Negative Elongation Factor E2
NELF-E2 3     Negative Elongation Factor Polypeptide E2
RD2 3     Nuclear Protein2
RNA-Binding Protein RD2 3     

External Ids:    HGNC: 139741   Entrez Gene: 79362   Ensembl: ENSG000002043567   OMIM: 1540405   UniProtKB: P186153   

Export aliases for NELFE gene to outside databases

Previous GC identifer: GC06M031925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NELFE Gene:
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA
polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it
has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and
acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility
complex (MHC) class III region on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for NELFE Gene:
NELFE (negative elongation factor complex member E) is a protein-coding gene. Diseases associated with NELFE include kaposi's sarcoma, and choroiditis. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: NELFE_HUMAN, P18615
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
causes transcriptional pausing, is counteracted by the P-TEFb kinase complex

Gene Wiki entry for NELFE (RDBP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  NT_167248.2  NT_167249.2  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NELFE
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELFE promoter sequence
   Search Chromatin IP Primers for NELFE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NELFE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NELFE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELFE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031926:  view genomic region     (about GC identifiers)

Start:
31,919,864 bp from pter      End:
31,926,887 bp from pter
Size:
7,024 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167247 3,299,708-3,306,708      Chr6-,NT_167248 3,213,658-3,220,653      Chr6-,NT_113891.2 3,429,620-3,436,620     
Chr6-,NT_167245 3,205,452-3,212,447      Chr6-,NT_167249 3,252,574-3,259,574     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NELFE_HUMAN, P18615 (See protein sequence)
Recommended Name: Negative elongation factor E  
Size: 380 amino acids; 43240 Da
Subunit: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE
3 PDB 3D structures from and Proteopedia for NELFE:
1X5P (3D)        2BZ2 (3D)        2JX2 (3D)    
Secondary accessions: A2BE08 Q5JP74 Q5JP75 Q96F56 Q9NPK2

Explore the universe of human proteins at neXtProt for NELFE: NX_P18615

Explore proteomics data for NELFE at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys130
  • Modification sites at PhosphoSitePlus

  • See NELFE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002895.3  
    ENSEMBL proteins: 
     ENSP00000364578   ENSP00000364574   ENSP00000388400   ENSP00000397914   ENSP00000409389  
     ENSP00000414029   ENSP00000419183   ENSP00000394340   ENSP00000420205  
    Reactome Protein details: P18615

    NELFE Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P18615

    ProtoNet protein and cluster: P18615

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: NELFE_HUMAN, P18615
    Domain: The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required
    for the NELF complex formation
    Similarity: Belongs to the RRM NELF-E family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    NELFE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NELFE_HUMAN, P18615
    Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
    transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
    causes transcriptional pausing, is counteracted by the P-TEFb kinase complex

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS2119325
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI12612062
         
    NELFE for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target NELFE:
    hsa-mir-877-5p (MIRT037249), hsa-mir-26b-5p (MIRT029251), hsa-mir-628-5p (MIRT037783)

    Block miRNA regulation of human, mouse, rat NELFE using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NELFE_HUMAN, P18615: Nucleus

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS2119325
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion ----
    GO:0032021NELF complex IDA12612062

    NELFE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NELFE About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Formation of the Early Elongation Complex0.77
    RNA Polymerase II Pre-transcription Events0.73
    Formation of the HIV-1 Early Elongation Complex0.77
    Pausing and recovery of HIV elongation0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    HIV elongation arrest and recovery0.73
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for NELFE (see all 13)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of the Early Elongation Complex
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript



    NELFE for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NELFE
    Interactions:

        Search GeneGlobe Interaction Network for NELFE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NELFE (P186151, 2, 3 ENSP000003645784) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFBQ8WX921, 2, 3, ENSP000003394954EBI-348444,EBI-347721 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 STRING: ENSP00000339495
    NCOR1O753762, 3, ENSP000002687124MINT-62763 MINT-62589 MINT-62687 I2D: score=5 STRING: ENSP00000268712
    VAMP3Q158363, ENSP000000546664I2D: score=4 STRING: ENSP00000054666
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0008150biological_process ND--
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--

    NELFE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NELFE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NELFE gene: 
    NM_002904.5  

    Unigene Cluster for NELFE:

    Negative elongation factor complex member E
    Hs.423935  [show with all ESTs]
    Unigene Representative Sequence: AK303152
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375429(uc003nyk.3 uc011dot.2 uc021yvb.1) ENST00000492185
    ENST00000488426 ENST00000481121 ENST00000375425 ENST00000444811 ENST00000441998
    ENST00000454913 ENST00000436289 ENST00000492539 ENST00000426722 ENST00000491139
    ENST00000494956
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat NELFE

    Additional mRNA sequence: 

    AK300717.1 AK300898.1 AK302652.1 AK303152.1 BC025235.1 BC050617.2 JQ313904.1 L03411.1 
    X16105.1 

    17 DOTS entries:

    DT.315991  DT.121361291  DT.100819398  DT.100819397  DT.100666227  DT.121361600  DT.100819378  DT.95216627 
    DT.121361281  DT.95216610  DT.95216614  DT.100819399  DT.121361602  DT.121361664  DT.444954  DT.97846266 
    DT.100819380 

    Selected AceView cDNA sequences (see all 273):

    BM700429 AW182699 CR626781 AA865468 CD673135 BQ925925 BU166785 AU102352 
    AA384700 AU102355 AU102353 BI522640 BE772444 AA348979 AI089409 BP346885 
    AA299377 CN485234 BQ676870 AA583036 BM458980 CR592359 AL519468 AI084534 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    NELFE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NELFE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.423935

    UniProtKB/Swiss-Prot: NELFE_HUMAN, P18615
    Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney
    and pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NELFE gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nelfe1 , 5 RD RNA-binding protein5
    negative elongation factor complex member E, Rdbp1
    87.47(n)1
    92.64(a)1
      17 (18.40 cM)5
    276321  NM_001045863.11  NP_001039328.11 
     348503985 
    chicken
    (Gallus gallus)
    Aves NELFE6
    negative elongation factor complex member E
    65(a)
    1 ↔ 1
    26(483316-486297)
    lizard
    (Anolis carolinensis)
    Reptilia NELFE6
    negative elongation factor complex member E
    75(a)
    1 ↔ 1
    2(194195735-194210789)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89142 Xenopus laevis transcribed sequence with weak similarity more 73.75(n)    BU909545.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257332 Danio rerio class III histocompatibility antigen RD more 74.24(n)    AY391454.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nelf-E6
    Negative elongation factor E
    36(a)
    1 ↔ 1
    3L(8592542-8593979)


    ENSEMBL Gene Tree for NELFE (if available)
    TreeFam Gene Tree for NELFE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NELFE gene
    3 SIMAP similar genes for NELFE using alignment to 9 protein entries:     NELFE_HUMAN (see all proteins):
    RD    RDBP    NELF-E

    NELFE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NELFE (see all 99)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880506081,2
    --31920487(+) ACCTCC/TGTAGC 1 -- int10--------
    rs1913648721,2
    --31920536(+) TTGCCA/TGAAGG 1 -- int10--------
    rs41516631,2
    C,F,H--31920597(+) TACTTT/CCAGGG 1 -- int111Minor allele frequency- C:0.02NS EA WA 1384
    rs5505131,2
    C,F,O,A,H--31920687(-) GGCTTG/AAGAGA 1 -- int123Minor allele frequency- A:0.11NA NS EA WA 2472
    rs41516641,2
    C,F,H--31920873(+) TGTGTC/TCTTTT 1 -- int130Minor allele frequency- T:0.12NS EA WA CSA NA 3486
    rs41516651,2
    C,F--31921066(+) GGGTCG/-TTTTT 1 -- int12Minor allele frequency- -:0.09NS 80
    rs2019107331,2
    --31921066(+) GGTCG-/TTTTTT 1 -- int10--------
    rs1486058981,2
    C--31921247(+) TGAGAC/TACTCA 1 -- int10--------
    rs20726321,2
    C,F,H--31921475(-) ATCCTC/TTCCCC 1 -- int1 trp325Minor allele frequency- T:0.31EA NS MN NA EU 4947
    rs283856461,2
    C,F,H--31921486(+) GGGAAA/GGGAAG 1 -- int1 trp34Minor allele frequency- G:0.01NS EU 1043

    HapMap Linkage Disequilibrium report for NELFE (31919864 - 31926887 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NELFE: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NELFE
    DNA2.0 Custom Variant and Variant Library Synthesis for NELFE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154040    OMIM disorders: --

    11 diseases for NELFE:    About MalaCards
    kaposi's sarcoma    choroiditis    hiv-1    hepatitis c virus
    systemic lupus erythematosus    sarcoma    lupus erythematosus    hepatocellular carcinoma
    hepatitis c    malaria    hepatitis


    NELFE for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Export disorders for NELFE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NELFE gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with NELFE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RD protein is closely related to nuclear RNA-binding proteins and has been highly conserved. (PubMed id 2119325)1, 2, 9 Surowy C.S.... Spritz R.A. (Gene 1990)
    2. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. (PubMed id 12612062)1, 2, 9 Narita T....Handa H. (Mol. Cell. Biol. 2003)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription. (PubMed id 16898873)1, 2 Rao J.N.... Wohrl B.M. (Biochem. J. 2006)
    6. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    10. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. (PubMed id 11940650)1, 2 Yamaguchi Y.... Handa H. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7936 HGNC: 13974 AceView: RDBP Ensembl:ENSG00000204356 euGenes: HUgn7936
    ECgene: NELFE H-InvDB: NELFE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NELFE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NELFE gene:
    Search GeneIP for patents involving NELFE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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