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Aliases for NELFCD Gene

Aliases for NELFCD Gene

  • Negative Elongation Factor Complex Member C/D 2 3
  • TH1L 3 4 6
  • TH1 3 4 6
  • Trihydrophobin 1 2 3
  • TH1-Like Protein 3 4
  • NELF-C/D 3 4
  • Negative Elongation Factor Proteins C And D 3
  • Negative Elongation Factor C/D 3
  • TH1-Like (Drosophila Homolog) 2
  • TH1 Drosophila Homolog 3
  • TH1-Like (Drosophila) 2
  • HSPC130 3
  • NELF-C 3
  • NELF-D 3
  • NELFD 4

External Ids for NELFCD Gene

Previous Symbols for NELFCD Gene

  • TH1L

Summaries for NELFCD Gene

Entrez Gene Summary for NELFCD Gene

  • The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]

GeneCards Summary for NELFCD Gene

NELFCD (Negative Elongation Factor Complex Member C/D) is a Protein Coding gene. Among its related pathways are Disease and Gene Expression.

UniProtKB/Swiss-Prot for NELFCD Gene

  • Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene Wiki entry for NELFCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NELFCD Gene

Genomics for NELFCD Gene

Genomic Location for NELFCD Gene

Start:
58,981,208 bp from pter
End:
58,995,133 bp from pter
Size:
13,926 bases
Orientation:
Plus strand

Genomic View for NELFCD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NELFCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NELFCD Gene

No data available for Regulatory Elements for NELFCD Gene

Proteins for NELFCD Gene

  • Protein details for NELFCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH7-NELFD_HUMAN
    Recommended name:
    Negative elongation factor C/D
    Protein Accession:
    Q8IXH7
    Secondary Accessions:
    • B4DE06
    • Q9BYL2
    • Q9H405
    • Q9H888
    • Q9H8T3
    • Q9NVX5
    • Q9P029
    • Q9UGN1
    • Q9UGN2
    • Q9UGN3

    Protein attributes for NELFCD Gene

    Size:
    590 amino acids
    Molecular mass:
    66247 Da
    Quaternary structure:
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with ARAF1.
    SequenceCaution:
    • Sequence=AAF29094.1; Type=Frameshift; Positions=462, 464; Evidence={ECO:0000305}; Sequence=BAA91618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14519.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB64339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NELFCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NELFCD Gene

Proteomics data for NELFCD Gene at MOPED

Post-translational modifications for NELFCD Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys67, Lys125, and Lys272

Other Protein References for NELFCD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NELFCD Gene

Domains for NELFCD Gene

Protein Domains for NELFCD Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NELFD_HUMAN
Family:
  • Belongs to the NELF-D family.:
    • Q8IXH7
genes like me logo Genes that share domains with NELFCD: view

No data available for Gene Families for NELFCD Gene

Function for NELFCD Gene

Molecular function for NELFCD Gene

UniProtKB/Swiss-Prot Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene Ontology (GO) - Molecular Function for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12612062
genes like me logo Genes that share ontologies with NELFCD: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NELFCD Gene

Localization for NELFCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NELFCD Gene

Gene Ontology (GO) - Cellular Components for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0032021 NELF complex IDA 12612062
genes like me logo Genes that share ontologies with NELFCD: view

Pathways for NELFCD Gene

genes like me logo Genes that share pathways with NELFCD: view

Pathways by source for NELFCD Gene

Gene Ontology (GO) - Biological Process for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NELFCD: view

Transcripts for NELFCD Gene

Unigene Clusters for NELFCD Gene

Negative elongation factor complex member C/D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NELFCD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NELFCD Gene

GeneLoc Exon Structure for
NELFCD
ECgene alternative splicing isoforms for
NELFCD

Expression for NELFCD Gene

mRNA expression in normal human tissues for NELFCD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NELFCD Gene

SOURCE GeneReport for Unigene cluster for NELFCD Gene Hs.517148

mRNA Expression by UniProt/SwissProt for NELFCD Gene

Q8IXH7-NELFD_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
genes like me logo Genes that share expressions with NELFCD: view

Orthologs for NELFCD Gene

This gene was present in the common ancestor of animals.

Orthologs for NELFCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TH1L 36
  • 99.72 (n)
  • 99.67 (a)
TH1L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC514958 36
  • 89.19 (n)
  • 98.47 (a)
NELFCD 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC477276 36
  • 90.63 (n)
  • 98.38 (a)
NELFCD 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nelfcd 36
  • 87.51 (n)
  • 97.46 (a)
Nelfcd 16
Nelfcd 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NELFCD 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NELFCD 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nelfcd 36
  • 87.8 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves TH1L 36
  • 81.14 (n)
  • 96.89 (a)
TH1L 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NELFCD 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3030 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nelfcd 36
  • 79.89 (n)
  • 92.41 (a)
Str.10276 36
zebrafish
(Danio rerio)
Actinopterygii nelfcd 36
  • 78.7 (n)
  • 90.85 (a)
nelfcd 37
  • 90 (a)
OneToOne
zgc55482 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000391 36
  • 60.31 (n)
  • 57.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta TH1 36
  • 58.38 (n)
  • 54.61 (a)
TH1 37
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4834 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for NELFCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NELFCD Gene

ENSEMBL:
Gene Tree for NELFCD (if available)
TreeFam:
Gene Tree for NELFCD (if available)

Paralogs for NELFCD Gene

Selected SIMAP similar genes for NELFCD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NELFCD: view

No data available for Paralogs for NELFCD Gene

Variants for NELFCD Gene

Sequence variations from dbSNP and Humsavar for NELFCD Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs149265 -- 58,991,582(+) TTCTG(C/T)GTAGA intron-variant
rs151333 -- 58,981,240(+) ccgcc(C/T)gtccc utr-variant-5-prime, upstream-variant-2KB
rs151362 -- 58,979,256(+) ctacc(A/C)ggaca upstream-variant-2KB
rs151363 -- 58,982,217(+) AATGG(C/T)GCCAT intron-variant
rs151453 -- 58,980,337(+) agtgc(A/G)gtggt upstream-variant-2KB

Relevant External Links for NELFCD Gene

HapMap Linkage Disequilibrium report
NELFCD

No data available for Structural Variations from Database of Genomic Variants (DGV) for NELFCD Gene

Disorders for NELFCD Gene

No disorders were found for NELFCD Gene.

No data available for UniProtKB/Swiss-Prot for NELFCD Gene

Publications for NELFCD Gene

  1. Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13. (PMID: 11030415) Bonthron D.T. … Strain L. (Hum. Genet. 2000) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. Trihydrophobin 1 is a new negative regulator of A-Raf kinase. (PMID: 14684750) Liu W. … Gu J. (J. Biol. Chem. 2004) 3 23
  4. Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP). (PMID: 17131388) Yang Y. … Gu J. (J. Cell. Biochem. 2007) 3 23
  5. Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. (PMID: 19136554) Cheng C. … Gu J. (J. Biol. Chem. 2009) 3 23

Products for NELFCD Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NELFCD
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NELFCD
    • Block miRNA regulation of NELFCD using miScript Target Protectors

    Sources for NELFCD Gene

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