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Aliases for NELFCD Gene

Aliases for NELFCD Gene

  • Negative Elongation Factor Complex Member C/D 2 3 5
  • Trihydrophobin 1 2 3
  • TH1-Like Protein 3 4
  • NELF-C/D 3 4
  • TH1L 3 4
  • TH1 3 4
  • Negative Elongation Factor Proteins C And D 3
  • Negative Elongation Factor C/D 3
  • TH1-Like (Drosophila Homolog) 2
  • TH1 Drosophila Homolog 3
  • TH1-Like (Drosophila) 2
  • TH1-Like 3
  • HSPC130 3
  • NELF-C 3
  • NELF-D 3
  • NELFD 4

External Ids for NELFCD Gene

Previous HGNC Symbols for NELFCD Gene

  • TH1L

Previous GeneCards Identifiers for NELFCD Gene

  • GC20P057557

Summaries for NELFCD Gene

Entrez Gene Summary for NELFCD Gene

  • The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]

GeneCards Summary for NELFCD Gene

NELFCD (Negative Elongation Factor Complex Member C/D) is a Protein Coding gene. Diseases associated with NELFCD include Hyperlucent Lung and Ascaridiasis. Among its related pathways are HIV Life Cycle and Gene Expression.

UniProtKB/Swiss-Prot for NELFCD Gene

  • Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene Wiki entry for NELFCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NELFCD Gene

Genomics for NELFCD Gene

Regulatory Elements for NELFCD Gene

Enhancers for NELFCD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F058360 0.5 ENCODE 63.9 -619.7 -619657 1.1 ZFP64 SIN3A YBX1 FOS ZNF202 ZNF680 HCFC1 ZBTB11 ZHX2 GATAD2B LOC101927932 NELFCD RAB22A ENSG00000270951 PPP4R1L PIR40663 VAPB
GH20F058248 0.6 ENCODE 42.9 -733.0 -733029 0.1 CTCF ZNF266 ZNF140 RAD21 ZNF664 ZNF791 ZNF138 ZNF143 ZNF433 ZNF202 LOC101927932 NELFCD ENSG00000270951 ANKRD60 PPP4R1L
GH20F059970 0.5 ENCODE 42.9 +991.0 990953 2.4 ZNF266 ZNF140 ZNF101 KAT2B ZKSCAN1 ZNF664 ZNF791 ZNF138 ZNF354C MAFK NELFCD CDH26 C20orf197
GH20F059039 0.2 ENCODE 42.7 +61.0 60978 4.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS SP3 NELFCD ZNF831 LOC101927932 GNAS PRELID3B SLMO2-ATP5E ATP5E
GH20F058980 0.8 FANTOM5 ENCODE 41.3 +0.7 720 2.5 HDGF ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 SP5 NELFCD ENSG00000254419 LOC101927932 ZNF831 STX16 GC20M058985
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NELFCD on UCSC Golden Path with GeneCards custom track

Promoters for NELFCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000403754 292 1801 HDGF ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3 SP5

Genomic Location for NELFCD Gene

Chromosome:
20
Start:
58,981,208 bp from pter
End:
58,995,134 bp from pter
Size:
13,927 bases
Orientation:
Plus strand

Genomic View for NELFCD Gene

Genes around NELFCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NELFCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NELFCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NELFCD Gene

Proteins for NELFCD Gene

  • Protein details for NELFCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH7-NELFD_HUMAN
    Recommended name:
    Negative elongation factor C/D
    Protein Accession:
    Q8IXH7
    Secondary Accessions:
    • B4DE06
    • Q9BYL2
    • Q9H405
    • Q9H888
    • Q9H8T3
    • Q9NVX5
    • Q9P029
    • Q9UGN1
    • Q9UGN2
    • Q9UGN3

    Protein attributes for NELFCD Gene

    Size:
    590 amino acids
    Molecular mass:
    66247 Da
    Quaternary structure:
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with ARAF1.
    SequenceCaution:
    • Sequence=AAF29094.1; Type=Frameshift; Positions=462, 464; Evidence={ECO:0000305}; Sequence=BAA91618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14519.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB64339.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NELFCD Gene

    Alternative splice isoforms for NELFCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NELFCD Gene

Post-translational modifications for NELFCD Gene

  • Ubiquitination at Lys 67, Lys 125, and Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for NELFCD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NELFCD (NELFCD)
  • Abcam antibodies for NELFCD

No data available for DME Specific Peptides for NELFCD Gene

Domains & Families for NELFCD Gene

Protein Domains for NELFCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NELFCD Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXH7

UniProtKB/Swiss-Prot:

NELFD_HUMAN :
  • Belongs to the NELF-D family.
Family:
  • Belongs to the NELF-D family.
genes like me logo Genes that share domains with NELFCD: view

No data available for Gene Families for NELFCD Gene

Function for NELFCD Gene

Molecular function for NELFCD Gene

UniProtKB/Swiss-Prot Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene Ontology (GO) - Molecular Function for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12612062
genes like me logo Genes that share ontologies with NELFCD: view
genes like me logo Genes that share phenotypes with NELFCD: view

Animal Model Products

miRNA for NELFCD Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NELFCD Gene

Localization for NELFCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NELFCD Gene

Gene Ontology (GO) - Cellular Components for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016020 membrane IDA 19946888
GO:0032021 NELF complex IDA 12612062
genes like me logo Genes that share ontologies with NELFCD: view

No data available for Subcellular locations from COMPARTMENTS for NELFCD Gene

Pathways & Interactions for NELFCD Gene

genes like me logo Genes that share pathways with NELFCD: view

Gene Ontology (GO) - Biological Process for NELFCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0050434 positive regulation of viral transcription TAS --
genes like me logo Genes that share ontologies with NELFCD: view

No data available for SIGNOR curated interactions for NELFCD Gene

Transcripts for NELFCD Gene

Unigene Clusters for NELFCD Gene

Negative elongation factor complex member C/D:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NELFCD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: -
SP7:
SP8:
SP9: -
SP10:

ExUns: 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NELFCD Gene

GeneLoc Exon Structure for
NELFCD
ECgene alternative splicing isoforms for
NELFCD

Expression for NELFCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NELFCD Gene

Protein differential expression in normal tissues from HIPED for NELFCD Gene

This gene is overexpressed in Bone (31.7) and Breast (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NELFCD Gene



Protein tissue co-expression partners for NELFCD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NELFCD Gene:

NELFCD

SOURCE GeneReport for Unigene cluster for NELFCD Gene:

Hs.517148

mRNA Expression by UniProt/SwissProt for NELFCD Gene:

Q8IXH7-NELFD_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.
genes like me logo Genes that share expression patterns with NELFCD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NELFCD Gene

Orthologs for NELFCD Gene

This gene was present in the common ancestor of animals.

Orthologs for NELFCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TH1L 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia NELFCD 35
  • 99 (a)
OneToOne
LOC477276 34
  • 90.63 (n)
cow
(Bos Taurus)
Mammalia NELFCD 35
  • 98 (a)
OneToOne
LOC514958 34
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia NELFCD 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NELFCD 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nelfcd 34
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Nelfcd 34 16 35
  • 87.51 (n)
chicken
(Gallus gallus)
Aves TH1L 34 35
  • 81.14 (n)
lizard
(Anolis carolinensis)
Reptilia NELFCD 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nelfcd 34
  • 79.89 (n)
Str.10276 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3030 34
zebrafish
(Danio rerio)
Actinopterygii nelfcd 34 35
  • 78.7 (n)
zgc55482 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000391 34
  • 60.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta TH1 34 35
  • 58.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4834 34
Species where no ortholog for NELFCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NELFCD Gene

ENSEMBL:
Gene Tree for NELFCD (if available)
TreeFam:
Gene Tree for NELFCD (if available)

Paralogs for NELFCD Gene

(1) SIMAP similar genes for NELFCD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NELFCD: view

No data available for Paralogs for NELFCD Gene

Variants for NELFCD Gene

Sequence variations from dbSNP and Humsavar for NELFCD Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10369 -- 58,995,401(+) TGTGT(C/T)GCAGG downstream-variant-500B, utr-variant-3-prime
rs1043219 -- 58,994,805(+) GATGA(C/G)TTCTT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1043414 -- 58,990,853(+) AAAAA(A/G)AACAG intron-variant
rs1043416 -- 58,990,856(+) AAGAA(A/C)AGAAA intron-variant
rs1043417 -- 58,990,858(+) GAACA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NELFCD Gene

Variant ID Type Subtype PubMed ID
nsv525118 CNV loss 19592680

Variation tolerance for NELFCD Gene

Residual Variation Intolerance Score: 8.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NELFCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NELFCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NELFCD Gene

Disorders for NELFCD Gene

MalaCards: The human disease database

(7) MalaCards diseases for NELFCD Gene - From: DISEASES

Disorder Aliases PubMed IDs
hyperlucent lung
  • lung, hyperlucent
ascaridiasis
  • ascariasis
pancoast tumor
  • malignant superior sulcus tumor
buruli ulcer
  • buruli ulcer disease
pericardial tuberculosis
  • tuberculous pericarditis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NELFCD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NELFCD
genes like me logo Genes that share disorders with NELFCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NELFCD Gene

Publications for NELFCD Gene

  1. Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13. (PMID: 11030415) Bonthron D.T. … Strain L. (Hum. Genet. 2000) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation. (PMID: 20069563) Yang Y. … Gu J. (J. Cell. Biochem. 2010) 3 22 64
  4. Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. (PMID: 19136554) Cheng C. … Gu J. (J. Biol. Chem. 2009) 3 22 64
  5. Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP). (PMID: 17131388) Yang Y. … Gu J. (J. Cell. Biochem. 2007) 3 22 64

Products for NELFCD Gene

Sources for NELFCD Gene

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