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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NELFCD Gene

protein-coding   GIFtS: 47
GCID: GC20P057557

Negative Elongation Factor Complex Member C/D

(Previous names: TH1-like (Drosophila homolog), TH1-like (Drosophila))
(Previous symbol: TH1L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Negative Elongation Factor Complex Member C/D1 2     TH1-Like (Drosophila)1
TH1L1 2 3 5     NELF-C2
TH12 3 5     NELF-D2
Trihydrophobin 11 2     Negative Elongation Factor C/D2
NELF-C/D2 3     Negative Elongation Factor Proteins C And D2
TH1-Like Protein2 3     TH1 Drosophila Homolog2
TH1-Like (Drosophila Homolog)1     NELFD3

External Ids:    HGNC: 159341   Entrez Gene: 514972   Ensembl: ENSG000001011587   OMIM: 6052975   UniProtKB: Q8IXH73   

Export aliases for NELFCD gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NELFCD Gene:
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA
polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation
initiation site usage results in the formation of two isoforms with different N-termini. (provided by RefSeq, Jul
2008)

GeneCards Summary for NELFCD Gene: 
NELFCD (negative elongation factor complex member C/D) is a protein-coding gene. Diseases associated with NELFCD include autoimmune thyroiditis, and papilloma, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and HIV Life Cycle. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NELFD_HUMAN, Q8IXH7
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
causes transcriptional pausing, is counteracted by the P-TEFb kinase complex

Gene Wiki entry for NELFCD (TH1L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NELFCD
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELFCD promoter sequence
   Search SABiosciences Chromatin IP Primers for NELFCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NELFCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13

NELFCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELFCD gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P057557:  view genomic region     (about GC identifiers)

Start:
57,556,263 bp from pter      End:
57,570,188 bp from pter
Size:
13,926 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NELFD_HUMAN, Q8IXH7 (See protein sequence)
Recommended Name: Negative elongation factor C/D  
Size: 590 amino acids; 66247 Da
Subunit: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.
Interacts with ARAF1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAF29094.1; Type=Frameshift; Positions=462, 464; Sequence=BAA91618.1; Type=Erroneous
initiation; Sequence=BAB14519.1; Type=Erroneous initiation; Sequence=CAB64339.1; Type=Erroneous initiation;
Secondary accessions: B4DE06 Q9BYL2 Q9H405 Q9H888 Q9H8T3 Q9NVX5 Q9P029 Q9UGN1 Q9UGN2 Q9UGN3
Alternative splicing, Alternative initiation: 3 isoforms:  Q8IXH7-1   Q8IXH7-3   Q8IXH7-4   (Produced by alternative initiation at Met-10 of isoform NELF-C)

Explore the universe of human proteins at neXtProt for NELFCD: NX_Q8IXH7

Explore proteomics data for NELFCD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXH7

  • NELFCD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NELFCD Protein Expression
    REFSEQ proteins: NP_945327.2  
    ENSEMBL proteins: 
     ENSP00000473290   ENSP00000436783   ENSP00000342300  
    Reactome Protein details: Q8IXH7
    Human Recombinant Protein Products for NELFCD: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0032021NELF complex IDA12612062

    NELFCD for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006942 TH1

    Graphical View of Domain Structure for InterPro Entry Q8IXH7

    ProtoNet protein and cluster: Q8IXH7

    UniProtKB/Swiss-Prot: NELFD_HUMAN, Q8IXH7
    Similarity: Belongs to the NELF-D family


    NELFCD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NELFD_HUMAN, Q8IXH7
    Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
    transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
    causes transcriptional pausing, is counteracted by the P-TEFb kinase complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12612062
         
    NELFCD for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NELFCD About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    HIV Transcription Elongation0.78
    Elongation arrest and recovery0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of HIV elongation0.74
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    Formation of the HIV-1 Early Elongation Complex0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    4Generic Transcription Pathway
    Gene Expression0.47
    5MAP Kinase Signaling
    MAP Kinase Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for NELFCD
        Chromatin Regulation / Acetylation
    MAP Kinase Signaling

    5/23        Reactome Pathways for NELFCD (see all 23)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    NELFCD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NELFCD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/678 Interacting proteins for NELFCD (Q8IXH71, 2, 3 ENSP000003423004) via UniProtKB, MINT, STRING, and/or I2D (see all 678)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARAFP103981, 2, 3, ENSP000003662444EBI-536725,EBI-365961 MINT-19318 I2D: score=5 STRING: ENSP00000366244
    DNAJA1P316892, 3MINT-64855 MINT-7945693 I2D: score=5 
    NELFAQ9H3P21, 3, ENSP000003723354EBI-6109710,EBI-5461341 I2D: score=2 STRING: ENSP00000372335
    COPB2P356062, 3, ENSP000003294194MINT-7945693 I2D: score=1 STRING: ENSP00000329419
    NELFBQ8WX922, 3, ENSP000003394954MINT-7945693 I2D: score=1 STRING: ENSP00000339495
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--

    NELFCD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NELFCD (NELFD)

    Search CenterWatch for drugs/clinical trials and news about NELFCD / NELFD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NELFCD gene (2 alternative transcripts): 
    NM_198976.2  NM_016397.2  

    Unigene Cluster for NELFCD:

    Negative elongation factor complex member C/D
    Hs.517148  [show with all ESTs]
    Unigene Representative Sequence: NM_198976
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602795 ENST00000471621 ENST00000492016 ENST00000464363 ENST00000482747
    ENST00000460601 ENST00000477741 ENST00000474543 ENST00000478389 ENST00000497935
    ENST00000490205 ENST00000479207 ENST00000486263 ENST00000344018(uc010zzu.1 uc002yaf.1 uc002yag.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF161479.1 AJ238375.1 AJ238376.1 AJ238379.1 AK001316.1 AK023927.1 AK094347.1 AK293410.1 
    AK304310.1 BC014952.1 BX647417.1 

    24/30 DOTS entries (see all 30):

    DT.95124705  DT.86859964  DT.100880633  DT.419135  DT.95234765  DT.95234766  DT.100880641  DT.100894875 
    DT.91813429  DT.120833587  DT.120833557  DT.120833574  DT.100880638  DT.120833547  DT.120833570  DT.448927 
    DT.102843059  DT.120833531  DT.95076726  DT.99927843  DT.100880634  DT.100880639  DT.120833511  DT.120833552 

    24/540 AceView cDNA sequences (see all 540):

    BI913917 AI825687 BP428898 BM015297 CB118767 AJ238374 BM469900 BU154864 
    BP347451 BE350317 BM665370 BM470641 NM_016397 CR616677 BG476560 AA449217 
    BM692700 BM818072 BM794387 AI913752 BE867586 BU734003 CR592487 AA559003 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NELFCD (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:                          -           -           -           -                 -                 -                                                         
    SP2:                                                                                -                 -                                                         
    SP3:                                                                                                                                      -                     
    SP4:                          -           -           -                                                                                                         
    SP5:                          -           -                                                                                                                     

    ExUns: 15b ^ 16a · 16b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NELFCD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NELFCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NELFCD Expression
    About this image


    See NELFCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NELFCD

    SOURCE GeneReport for Unigene cluster: Hs.517148

    UniProtKB/Swiss-Prot: NELFD_HUMAN, Q8IXH7
    Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac
    muscle, adrenal, thyroid, kidney and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NELFCD gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nelfcd5
    Th1l1
    TH1-like homolog (Drosophila)1, 5 87.51(n)1
    97.46(a)1
      2 (97.93 cM)5
    573141  NM_020580.31  NP_065605.21 
     1744158045 
    chicken
    (Gallus gallus)
    Aves TH1L1 TH1-like (Drosophila) 81.09(n)
    96.55(a)
      419312  NM_001006294.1  NP_001006294.1 
    lizard
    (Anolis carolinensis)
    Reptilia TH1L6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343475.1(535295-552382)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.30302 Xenopus laevis transcribed sequence with moderate similarity more 78.12(n)    CA974443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554822 similar to TH1-like homolog (Drosophila) 79.63(n)   394165  BC045357.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TH11 CG9984-PA 58.38(n)
    54.61(a)
      32607  NM_132895.2  NP_573123.1 


    ENSEMBL Gene Tree for NELFCD (if available)
    TreeFam Gene Tree for NELFCD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NELFCD gene
    1 SIMAP similar gene for NELFCD using alignment to 1 protein entry:     NELFD_HUMAN:
    TH1L

    NELFCD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/418 SNPs in NELFCD are shown (see all 418)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513621,2
    C,F,A--57554311(+) ctaccA/Cggaca 1 -- us2k1 tfbs39Minor allele frequency- C:0.28NA WA CSA EA 369
    rs37612601,2
    C--57554367(-) AGTGCC/TCAGCA 1 -- us2k14Minor allele frequency- T:0.08NA WA EA 360
    rs1465642251,2
    --57554386(+) ACTCAA/GTAAAC 1 -- us2k10--------
    rs130414311,2
    C,F--57554581(+) agcaaA/Tctgta 1 -- us2k17Minor allele frequency- T:0.26NA WA EA 366
    rs1413107091,2
    --57554651(+) ACAGGC/TGTGCA 1 -- us2k10--------
    rs1422634381,2
    --57554666(+) CATACC/TTGGCT 1 -- us2k10--------
    rs1116676741,2
    C,F--57554678(+) GGGGCG/AGGGGA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs114842391,2
    C--57554684(+) GGGGG-/GCGGTG 1 -- us2k1 tfbs30--------
    rs772261231,2
    C--57554684(+) GGGGAA/GGGGGG 1 -- us2k10--------
    rs1844429841,2
    --57554686(+) GGAAGC/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NELFCD (57556263 - 57570188 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NELFCD: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NELFCD
    DNA2.0 Custom Variant and Variant Library Synthesis for NELFCD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605297    OMIM disorders: --

    11 diseases for NELFCD:    About MalaCards
    autoimmune thyroiditis    papilloma    macular degeneration    atopic dermatitis
    dermatitis    ataxia    schizophrenia    arthritis
    squamous cell carcinoma    thyroiditis    breast cancer


    NELFCD for disorders           About GeneDecksing


    Export disorders for NELFCD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NELFCD gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with NELFCD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13. (PubMed id 11030415)1, 2, 3 Bonthron D.T.... Strain L. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. (PubMed id 12612062)1, 2 Narita T....Handa H. (2003)
    6. Identification of TH1 as an interaction partner of A-Raf kinase. (PubMed id 11952167)1, 2 Yin X.L.... Gu J.X. (2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. (PubMed id 10199401)1, 2 Yamaguchi Y.... Handa H. (1999)
    9. Trihydrophobin 1 is a new negative regulator of A-Raf kinase. (PubMed id 14684750)1, 9 Liu W....Gu J. (2004)
    10. Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP). (PubMed id 17131388)1, 9 Yang Y....Gu J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51497 HGNC: 15934 AceView: TH1L Ensembl:ENSG00000101158 euGenes: HUgn51497
    ECgene: NELFCD H-InvDB: NELFCD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NELFCD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NELFCD gene:
    Search GeneIP for patents involving NELFCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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