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NELFB Gene(Protein Coding)

Negative Elongation Factor Complex Member B

GCID:
GC09P137255
GIFtS:
47
Genes Participants
UDN Logo

Aliases for NELFB Gene

Aliases for NELFB Gene

  • Negative Elongation Factor Complex Member B 2 3 5
  • Cofactor Of BRCA1 2 3 4
  • COBRA1 3 4
  • NELF-B 3 4
  • Negative Elongation Factor Protein B 3
  • KIAA1182 4

External Ids for NELFB Gene

Previous HGNC Symbols for NELFB Gene

  • COBRA1

Previous GeneCards Identifiers for NELFB Gene

  • GC09P140150

Summaries for NELFB Gene

Entrez Gene Summary for NELFB Gene

  • NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NELFB Gene

NELFB (Negative Elongation Factor Complex Member B) is a Protein Coding gene. Among its related pathways are Formation of the HIV-1 Early Elongation Complex and Gene Expression.

UniProtKB/Swiss-Prot for NELFB Gene

  • Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

Gene Wiki entry for NELFB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NELFB Gene

Genomics for NELFB Gene

Products:

  1. Regulatory Element

Regulatory Elements for NELFB Gene

Enhancers for NELFB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NELFB on UCSC Golden Path with GeneCards custom track

Promoters for NELFB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NELFB on UCSC Golden Path with GeneCards custom track

Genomic Location for NELFB Gene

Chromosome:
9
Start:
137,255,173 bp from pter
End:
137,273,548 bp from pter
Size:
18,376 bases
Orientation:
Plus strand

Genomic View for NELFB Gene

Genes around NELFB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NELFB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NELFB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NELFB Gene

Proteins for NELFB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NELFB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WX92-NELFB_HUMAN
    Recommended name:
    Negative elongation factor B
    Protein Accession:
    Q8WX92
    Secondary Accessions:
    • A2BFA3
    • Q96EW5
    • Q9H9R4
    • Q9ULN8
    • Q9Y3W0

    Protein attributes for NELFB Gene

    Size:
    580 amino acids
    Molecular mass:
    65697 Da
    Quaternary structure:
    • The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE. Interacts with the first BRCT repeat of BRCA1. Interacts with KIAA1191.
    SequenceCaution:
    • Sequence=AAH11892.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14157.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43381.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NELFB Gene

Proteomics data for NELFB Gene at MOPED

Protein Expression for NELFB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NELFB Gene

  • Ubiquitination at Lys 99 and Lys 135
  • Modification sites at PhosphoSitePlus

Other Protein References for NELFB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NELFB (COBRA1)

No data available for DME Specific Peptides for NELFB Gene

Domains & Families for NELFB Gene

Protein Domains for NELFB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NELFB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WX92

UniProtKB/Swiss-Prot:

NELFB_HUMAN :
  • Belongs to the NELF-B family.
Family:
  • Belongs to the NELF-B family.
genes like me logo Genes that share domains with NELFB: view

No data available for Gene Families for NELFB Gene

Function for NELFB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NELFB Gene

UniProtKB/Swiss-Prot Function:
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

Phenotypes for NELFB Gene

MGI mutant phenotypes for NELFB:
inferred from 2 alleles
GenomeRNAi human phenotypes for NELFB:
genes like me logo Genes that share phenotypes with NELFB: view

Animal Models for NELFB Gene

MGI Knock Outs for NELFB:

Animal Model Products

CRISPR Products

miRNA for NELFB Gene

miRTarBase miRNAs that target NELFB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NELFB Gene

Localization for NELFB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NELFB Gene

Nucleus.

Gene Ontology (GO) - Cellular Components for NELFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NELFB: view

No data available for Subcellular locations from COMPARTMENTS for NELFB Gene

Pathways & Interactions for NELFB Gene

genes like me logo Genes that share pathways with NELFB: view

Gene Ontology (GO) - Biological Process for NELFB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0050434 positive regulation of viral transcription TAS --
genes like me logo Genes that share ontologies with NELFB: view

No data available for SIGNOR curated interactions for NELFB Gene

Drugs & Compounds for NELFB Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NELFB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NELFB Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NELFB Gene

Negative elongation factor complex member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NELFB Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6: -

Relevant External Links for NELFB Gene

GeneLoc Exon Structure for
NELFB
ECgene alternative splicing isoforms for
NELFB

Expression for NELFB Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NELFB Gene

mRNA expression in normal human tissues for NELFB Gene
mRNA expression by BioGPS for NELFB GenemRNA expression by GTEx for NELFB Gene

Protein differential expression in normal tissues from HIPED for NELFB Gene

This gene is overexpressed in Bone (19.1) and Breast (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NELFB Gene



SOURCE GeneReport for Unigene cluster for NELFB Gene Hs.521809

mRNA Expression by UniProt/SwissProt for NELFB Gene

Q8WX92-NELFB_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with NELFB: view

Protein tissue co-expression partners for NELFB Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NELFB Gene

Orthologs for NELFB Gene

This gene was present in the common ancestor of animals.

Orthologs for NELFB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia NELFB 35
  • 89.37 (n)
  • 96.38 (a)
COBRA1 36
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia NELFB 35
  • 89.48 (n)
  • 96.21 (a)
NELFB 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nelfb 35
  • 85.63 (n)
  • 95.86 (a)
Nelfb 16
Nelfb 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia COBRA1 35
  • 98.3 (n)
  • 98.56 (a)
NELFB 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Nelfb 35
  • 86.15 (n)
  • 96.55 (a)
oppossum
(Monodelphis domestica)
 Mammalia NELFB 36
  • 91 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NELFB 36
  • 84 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves COBRA1 35
  • 78.26 (n)
  • 87.3 (a)
COBRA1 36
  • 87 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NELFB 36
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nelfb 35
  • 76.91 (n)
  • 80.45 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7402 35
zebrafish
(Danio rerio)
 Actinopterygii nelfb 35
  • 71.9 (n)
  • 77.31 (a)
zgc55628 35
nelfb 36
  • 73 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP012109 35
  • 62.76 (n)
  • 54.69 (a)
fruit fly
(Drosophila melanogaster)
 Insecta NELF-B 35
  • 59 (n)
  • 54.34 (a)
NELF-B 36
  • 51 (a)
 OneToOne
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.3713 35
Species with no ortholog for NELFB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NELFB Gene

ENSEMBL:
Gene Tree for NELFB (if available)
TreeFam:
Gene Tree for NELFB (if available)

Paralogs for NELFB Gene

No data available for Paralogs for NELFB Gene

Variants for NELFB Gene

Sequence variations from dbSNP and Humsavar for NELFB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1135234 -- 137,271,132(+) AATCA(A/G)GGCAT intron-variant
rs113157916 -- 137,258,944(+) CACGC(A/C)TGTAC intron-variant
rs113300551 -- 137,267,889(+) GAGCT(C/G)TCTTT intron-variant
rs113349391 -- 137,265,843(+) AACAG(A/G)CGTCG intron-variant
rs113542502 -- 137,261,816(+) CAAGA(A/C/T)GCGGA intron-variant

Variation tolerance for NELFB Gene

Residual Variation Intolerance Score: 7.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NELFB Gene

Disorders for NELFB Gene

Relevant External Links for NELFB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NELFB

No disorders were found for NELFB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NELFB Gene

Publications for NELFB Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Deregulation of cofactor of BRCA1 expression in breast cancer cells. (PMID: 17910036) Sun J. … Li R. (J. Cell. Biochem. 2008) 2 3 23
  3. Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing. (PMID: 17659869) Sun J. … Li R. (J. Steroid Biochem. Mol. Biol. 2007) 2 3 23
  4. Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas. (PMID: 16452188) McChesney P.A. … El-Rifai W. (Cancer Res. 2006) 3 23
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3

Products for NELFB Gene

Sources for NELFB Gene

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