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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NELFB Gene

protein-coding   GIFtS: 49
GCID: GC09P140150

Negative Elongation Factor Complex Member B

(Previous name: cofactor of BRCA1)
(Previous symbol: COBRA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Negative Elongation Factor Complex Member B1 2     KIAA11823 5
COBRA11 2 3 5     Negative Elongation Factor B2
Cofactor Of BRCA11 2 3     Negative Elongation Factor Protein B2
NELF-B2 3     

External Ids:    HGNC: 243241   Entrez Gene: 259202   Ensembl: ENSG000001889867   OMIM: 6111805   UniProtKB: Q8WX923   

Export aliases for NELFB gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NELFB Gene:
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either
NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor
(DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional
pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 (PubMed 12612062)).(supplied by OMIM, Mar
2008)

GeneCards Summary for NELFB Gene: 
NELFB (negative elongation factor complex member B) is a protein-coding gene. Diseases associated with NELFB include adenocarcinoma, and breast cancer, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and HIV Life Cycle. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NELFB_HUMAN, Q8WX92
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin
unfolding

Gene Wiki entry for NELFB (Cofactor of BRCA1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_024000.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NELFB
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELFB promoter sequence
   Search SABiosciences Chromatin IP Primers for NELFB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NELFB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

NELFB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELFB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140150:  view genomic region     (about GC identifiers)

Start:
140,149,625 bp from pter      End:
140,168,000 bp from pter
Size:
18,376 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NELFB_HUMAN, Q8WX92 (See protein sequence)
Recommended Name: Negative elongation factor B  
Size: 580 amino acids; 65697 Da
Subunit: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.
Interacts with the first BRCT repeat of BRCA1. Interacts with KIAA1191
Subcellular location: Nucleus
Sequence caution: Sequence=AAH11892.1; Type=Erroneous initiation; Sequence=BAB14157.1; Type=Erroneous initiation;
Sequence=CAB43381.3; Type=Erroneous initiation;
Secondary accessions: A2BFA3 Q96EW5 Q9H9R4 Q9ULN8 Q9Y3W0

Explore the universe of human proteins at neXtProt for NELFB: NX_Q8WX92

Explore proteomics data for NELFB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WX92

  • NELFB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NELFB Protein Expression
    REFSEQ proteins: NP_056271.2  
    ENSEMBL proteins: 
     ENSP00000339495  
    Reactome Protein details: Q8WX92
    Human Recombinant Protein Products for NELFB: 
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    Novus Biologicals NELFB Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0032021NELF complex IDA12612062

    NELFB for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010405 COBRA1

    Graphical View of Domain Structure for InterPro Entry Q8WX92

    ProtoNet protein and cluster: Q8WX92

    1 Blocks protein domain: IPB010405 Cofactor of BRCA1

    UniProtKB/Swiss-Prot: NELFB_HUMAN, Q8WX92
    Similarity: Belongs to the NELF-B family


    NELFB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NELFB_HUMAN, Q8WX92
    Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
    transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
    causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin
    unfolding

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11739404
         
    NELFB for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NELFB:
     Decreased nuclei size in G2M  Increased S DNA content, incre 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nelfb):
     embryogenesis  mortality/aging  no phenotypic analysis 

    NELFB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NELFB: Nelfbtm1.2Roli Nelfbtm1.1Roli

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NELFB 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NELFB About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    HIV Transcription Elongation0.78
    Elongation arrest and recovery0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of HIV elongation0.74
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    Formation of the HIV-1 Early Elongation Complex0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    4Generic Transcription Pathway
    Gene Expression0.47
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/23        Reactome Pathways for NELFB (see all 23)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    NELFB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NELFB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/851 Interacting proteins for NELFB (Q8WX921, 2, 3 ENSP000003394954) via UniProtKB, MINT, STRING, and/or I2D (see all 851)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206268P186151, 2, 3EBI-347721,EBI-348444 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 
    ENSG00000206357P186151, 2, 3EBI-347721,EBI-348444 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 
    ENSG00000229363P186151, 2, 3EBI-347721,EBI-348444 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 
    ENSG00000231044P186151, 2, 3EBI-347721,EBI-348444 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 
    ENSG00000233801P186151, 2, 3EBI-347721,EBI-348444 MINT-62588 MINT-62762 MINT-62686 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--

    NELFB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NELFB

    Search CenterWatch for drugs/clinical trials and news about NELFB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NELFB gene: 
    NM_015456.3  

    Unigene Cluster for NELFB:

    Negative elongation factor complex member B
    Hs.521809  [show with all ESTs]
    Unigene Representative Sequence: NM_015456
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343053(uc004cmm.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NELFB
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    Additional mRNA sequence: 

    AB033008.1 AF464935.1 AK022651.1 AK091056.1 AL050280.1 BC011892.1 BC019029.1 

    19 DOTS entries:

    DT.313483  DT.100650419  DT.95345105  DT.100847227  DT.92443894  DT.95345115  DT.95345119  DT.97773518 
    DT.95345123  DT.99983202  DT.100042649  DT.100650416  DT.100680128  DT.87016426  DT.95244950  DT.95345116 
    DT.95345117  DT.101984995  DT.121153312 

    24/64 AceView cDNA sequences (see all 64):

    AW958901 BU069420 BM711554 AW134507 CB055237 AA434318 BM665469 BM724872 
    CK818997 BM126403 BU741500 CK818996 BX379467 BM126112 AI380693 AW674821 
    AA434230 BM981784 BX354686 AW673957 F36882 BE256079 AL522505 BU069633 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NELFB (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:        -                 -           -                                   -                                             
    SP2:        -                 -                                                                                             
    SP3:                          -           -                                                                                 
    SP4:                                                                                                                        
    SP5:        -                                                                                                               


    ECgene alternative splicing isoforms for NELFB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NELFB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NELFB Expression
    About this image


    See NELFB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NELFB

    SOURCE GeneReport for Unigene cluster: Hs.521809

    UniProtKB/Swiss-Prot: NELFB_HUMAN, Q8WX92
    Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney
    and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELFB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NELFB gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nelfb5
    Cobra11
    cofactor of BRCA11, 5 85.63(n)1
    95.86(a)1
      2 (17.06 cM)5
    582021  NM_021393.21  NP_067368.21 
     251997125 
    chicken
    (Gallus gallus)
    Aves COBRA11 cofactor of BRCA1 78.26(n)
    87.3(a)
      417254  NM_001006202.1  NP_001006202.1 
    lizard
    (Anolis carolinensis)
    Reptilia COBRA16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343625.1(182928-200500)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.74022 Xenopus laevis transcribed sequence with moderate similarity more 79.32(n)    CA790314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556282 similar to cofactor of BRCA1 75.39(n)   393137  BC045409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NELF-B1 CG32721-PA 58.98(n)
    54.43(a)
      31681  NM_132174.2  NP_572402.1 


    ENSEMBL Gene Tree for NELFB (if available)
    TreeFam Gene Tree for NELFB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/573 SNPs in NELFB are shown (see all 573)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996813351,2
    --140150003(+) GGCGAA/GGACCT 2 E syn10--------
    rs2012919261,2
    C--140150039(+) GAGCCG/TCTCAA 2 P syn10--------
    rs2007809411,2
    C--140150054(+) ATCGAA/GCAGTT 2 E syn10--------
    rs1901996861,2
    --140150143(+) GGCGCC/TGGAAG 1 -- int10--------
    rs784692341,2
    C,F--140150288(+) GCCTCC/TCTGTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs115331551,2
    C,F,H--140150310(-) GGGCAC/TCCCGA 1 -- int118Minor allele frequency- T:0.14NS EA NA CSA WA EU 2916
    rs2001298621,2
    --140150348(+) CTCTTA/GGCTTC 1 -- int10--------
    rs1824284921,2
    C--140150353(+) GGCTTC/TCTCAG 1 -- int10--------
    rs1468369791,2
    C,F--140150413(+) TGGACC/TTGCAC 2 L syn12Minor allele frequency- T:0.02NA EU 5743
    rs1411536201,2
    C--140150427(+) ACGCCG/TCGGCT 2 P syn11Minor allele frequency- T:0.00NA 4536

    HapMap Linkage Disequilibrium report for NELFB (140149625 - 140168000 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NELFB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NELFB
    DNA2.0 Custom Variant and Variant Library Synthesis for NELFB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611180    OMIM disorders: --

    2 diseases for NELFB:    About MalaCards
    adenocarcinoma    breast cancer


    NELFB for disorders           About GeneDecksing


    Export disorders for NELFB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NELFB gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with NELFB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2, 3 Hirosawa M.... Ohara O. (1999)
    3. Deregulation of cofactor of BRCA1 expression in breas t cancer cells. (PubMed id 17910036)1, 3, 9 Sun J....Li R. (2008)
    4. Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing. (PubMed id 17659869)1, 3, 9 Sun J....Li R. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. (PubMed id 12612062)1, 2 Narita T....Handa H. (2003)
    8. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. (PubMed id 11739404)1, 2 Ye Q.... Li R. (2001)
    9. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. (PubMed id 10199401)1, 2 Yamaguchi Y.... Handa H. (1999)
    10. Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas. (PubMed id 16452188)1, 9 McChesney P.A....El-Rifai W. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25920 HGNC: 24324 AceView: COBRA1 Ensembl:ENSG00000188986 euGenes: HUgn25920
    ECgene: NELFB H-InvDB: NELFB

    (According to HUGE)
    About This Section
    HUGE: KIAA1182

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NELFB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NELFB gene:
    Search GeneIP for patents involving NELFB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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