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NELFA Gene

protein-coding   GIFtS: 46
GCID: GC04M001985

Negative Elongation Factor Complex Member A

(Previous name: Wolf-Hirschhorn syndrome candidate 2)
(Previous symbol: WHSC2)
  See NELFA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Negative Elongation Factor Complex Member A1 2
WHSC21 2 3 5
Wolf-Hirschhorn Syndrome Candidate 2 Protein2 3
NELF-A2 3
Wolf-Hirschhorn Syndrome Candidate 21
Negative Elongation Factor A2

External Ids:    HGNC: 127681   Entrez Gene: 74692   Ensembl: ENSG000001850497   OMIM: 6060265   UniProtKB: Q9H3P23   

Export aliases for NELFA gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NELFA Gene:
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein
sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome
associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb
WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded
protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes,
suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has
also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the
regulation of RNA polymerase II transcription elongation. (provided by RefSeq, Jul 2008)

GeneCards Summary for NELFA Gene:
NELFA (negative elongation factor complex member A) is a protein-coding gene. Diseases associated with NELFA include wolf-hirschhorn syndrome. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot: NELFA_HUMAN, Q9H3P2
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with
the RNA polymerase II complex

Gene Wiki entry for NELFA (WHSC2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NELFA
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNELFA promoter sequence
   Search Chromatin IP Primers for NELFA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NELFA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

NELFA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NELFA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M001985:  view genomic region     (about GC identifiers)

Start:
1,984,441 bp from pter      End:
2,043,630 bp from pter
Size:
59,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NELFA_HUMAN, Q9H3P2 (See protein sequence)
Recommended Name: Negative elongation factor A  
Size: 528 amino acids; 57277 Da
Subunit: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-C or isoform NELF-D) and NELFE.
Interacts with the RNA polymerase II complex when it is not phosphorylated by P-TEFb
Caution: PubMed:12612062 has shown that it is not involved in Wolf-Hirschhorn syndrome
Sequence caution: Sequence=AAC72982.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG54283.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAM15219.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=EAW82546.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2A2T1 O95392
Alternative splicing: 2 isoforms:  Q9H3P2-1   Q9H3P2-7   

Explore the universe of human proteins at neXtProt for NELFA: NX_Q9H3P2

Explore proteomics data for NELFA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys371
  • Modification sites at PhosphoSitePlus

  • See NELFA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005654.3  
    ENSEMBL proteins: 
     ENSP00000372335   ENSP00000399165   ENSP00000387647   ENSP00000330311   ENSP00000405119  
     ENSP00000395761   ENSP00000410154   ENSP00000410963   ENSP00000396996   ENSP00000387776  
     ENSP00000406844   ENSP00000445757  
    Reactome Protein details: Q9H3P2

    NELFA Human Recombinant Protein Products:

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    Novus Biologicals NELFA Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026305 NELF-A

    Graphical View of Domain Structure for InterPro Entry Q9H3P2

    ProtoNet protein and cluster: Q9H3P2

    UniProtKB/Swiss-Prot: NELFA_HUMAN, Q9H3P2
    Domain: The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the
    RNA polymerase II complex
    Similarity: Belongs to the NELF-A family
    Similarity: Contains 1 HDAg-like domain


    Find genes that share domains with NELFA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NELFA_HUMAN, Q9H3P2
    Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of
    transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and
    causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with
    the RNA polymerase II complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003746translation elongation factor activity ----
    GO:0005515protein binding IPI12612062
         
    Find genes that share ontologies with NELFA           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Nelfa (no phenotypes)

    Find genes that share phenotypes with NELFA           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NELFA
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    Addgene plasmids for NELFA 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NELFA_HUMAN, Q9H3P2: Nucleus

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0032021NELF complex IDA12612062

    Find genes that share ontologies with NELFA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NELFA About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Formation of the Early Elongation Complex0.77
    RNA Polymerase II Pre-transcription Events0.73
    Formation of the HIV-1 Early Elongation Complex0.77
    Pausing and recovery of HIV elongation0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    HIV elongation arrest and recovery0.73
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease


    Find genes that share SuperPaths with NELFA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for NELFA (see all 13)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of the Early Elongation Complex
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NELFA
    Interactions:

        Search GeneGlobe Interaction Network for NELFA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NELFA (Q9H3P21, 3 ENSP000003723354) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFEP186153, ENSP000003645784I2D: score=1 STRING: ENSP00000364578
    ENSG00000206268P186153I2D: score=1 
    ENSG00000206357P186153I2D: score=1 
    ENSG00000229363P186153I2D: score=1 
    ENSG00000231044P186153I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0007275multicellular organismal development TAS10409432
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--

    Find genes that share ontologies with NELFA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NELFA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NELFA gene: 
    NM_005663.4  

    Unigene Cluster for NELFA:

    Negative elongation factor complex member A
    Hs.21771  [show with all ESTs]
    Unigene Representative Sequence: AK126056
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382882(uc003gem.3 uc003gen.3) ENST00000467661(uc003gek.3)
    ENST00000411638 ENST00000463820(uc003gel.3) ENST00000416258 ENST00000333877
    ENST00000453740 ENST00000431323 ENST00000455762 ENST00000488452 ENST00000421397
    ENST00000484545 ENST00000411649 ENST00000443203 ENST00000458616 ENST00000542778

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NELFA
      QuantiFast Probe-based Assays in human, mouse, rat NELFA

    Additional mRNA sequence: 

    AF101434.1 AK001304.1 AK094040.1 AK095737.1 AK126056.1 AK222853.1 AK307117.1 BC002764.2 

    22 DOTS entries:

    DT.445769  DT.121259725  DT.100821458  DT.121259758  DT.95191572  DT.95191589  DT.121259723  DT.97819400 
    DT.121259696  DT.95191609  DT.102842476  DT.121259762  DT.92441657  DT.95191566  DT.100760402  DT.100821454 
    DT.100821455  DT.121259749  DT.121259753  DT.121259852  DT.40109591  DT.75187527 

    Selected AceView cDNA sequences (see all 285):

    CN484097 BE897239 AI640730 BE313847 BU156228 AW964201 BI522621 AW006316 
    BU957444 BU944746 BU631096 BM460302 BX283496 BX459382 BG424059 BM452971 
    AI611664 BX440448 AI217724 BX394808 BQ059419 BM563785 BU173067 BQ066397 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NELFA (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^
    SP1:                                -     -     -     -     -     -     -                       -                             -                                 
    SP2:                                                                                            -                             -                                 
    SP3:                                                                                            -                             -                                 
    SP4:                                -     -     -     -     -     -     -     -     -     -     -                             -                                 
    SP5:                                                                                                                                                            

    ExUns: 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for NELFA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NELFA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NELFA Expression
    About this image

    NELFA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NELFA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21771

    UniProtKB/Swiss-Prot: NELFA_HUMAN, Q9H3P2
    Tissue specificity: Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
    Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NELFA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NELFA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nelfa1 , 5 Wolf-Hirschhorn syndrome candidate 2 (human)5
    negative elongation factor complex member A, Whsc21
    85.1(n)1
    95.83(a)1
      5 (17.83 cM)5
    241161  NM_011914.21  NP_036044.11 
     338969365 
    chicken
    (Gallus gallus)
    Aves WHSC21 Wolf-Hirschhorn syndrome candidate 2 73.61(n)
    85.85(a)
      422896  NM_001031167.1  NP_001026338.1 
    lizard
    (Anolis carolinensis)
    Reptilia NELFA6
    negative elongation factor complex member A
    81(a)
    1 ↔ 1
    GL343297.1(127866-163756)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189472 Xenopus laevis transcribed sequence with moderate similarity more 76.87(n)    CD254084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi75f032 Danio rerio cDNA clone IMAGE5602672, partial cds 78.63(n)    BC054683.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nelf-A6
    Negative elongation factor A
    14(a)
    1 ↔ 1
    3R(17049426-17055234)


    ENSEMBL Gene Tree for NELFA (if available)
    TreeFam Gene Tree for NELFA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NELFA gene
    Selected SIMAP similar genes for NELFA using alignment to 11 protein entries:     NELFA_HUMAN (see all proteins) (see all similar genes):
    SLC35E3    ABI2    CDK10    HINFP    NEK4    EIF3G
    IRF2    ZNF799    PTPN22    PFKFB3    PPP5D1    IRF5
    ZNF180    PPP2R5C    ARIH1    VPS33A    FLJ00047    SEPSECS

    Find genes that share paralogs with NELFA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NELFA (see all 721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171321121,2
    C,F,H--1925843(+) TCAGAT/CAGTTT 1 -- ut3111Minor allele frequency- C:0.03NA NS EA WA 1348
    rs1833602511,2
    --1925850(+) GTTTTA/GCAATG 1 -- ut310--------
    rs1387011401,2
    --1925899(+) CAACTA/GTACAA 1 -- ut310--------
    rs31856921,2
    C,F--1925948(-) TGGGCC/ATTGTC 1 -- ut31 ese31Minor allele frequency- A:0.00MN 184
    rs801796001,2
    --1925955(+) CCCACC/TGTCTC 1 -- ut310--------
    rs1167688851,2
    C,F--1925965(+) CCCACG/ACTCTG 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1878517401,2
    --1926061(+) AGCGAA/GGGAAA 1 -- ut310--------
    rs2018418451,2
    C--1926100(+) TAACAA/GGCAGA 1 -- ut310--------
    rs1927347201,2
    --1926231(+) AATTTC/TAAAAA 1 -- ut310--------
    rs22345781,2
    C--1926318(-) GCCCCC/TGAGGT 1 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for NELFA (1984441 - 2043630 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NELFA: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NELFA
    DNA2.0 Custom Variant and Variant Library Synthesis for NELFA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606026    OMIM disorders: --

    1 disease for NELFA:    
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    wolf-hirschhorn syndrome


    Find genes that share disorders with NELFA           About GenesLikeMe

    1 Novoseek inferred disease relationship for NELFA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis delta 67.1 3 12612062 (1), 11387440 (1)


    Export disorders for NELFA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NELFA gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with NELFA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt- Rogers-Danks syndrome critical region. (PubMed id 10409432)1, 2, 3, 9 Wright T.J.... Altherr M.R. (Genomics 1999)
    2. Modulation of WHSC2 expression in human endothelial cells. (PubMed id 11150502)1, 2, 9 Mariotti M.... Maier J.A.M. (FEBS Lett. 2000)
    3. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. (PubMed id 12612062)1, 2, 9 Narita T....Handa H. (Mol. Cell. Biol. 2003)
    4. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. (PubMed id 11387440)1, 2, 9 Yamaguchi Y.... Handa H. (Science 2001)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2. (PubMed id 12563561)1, 2 Zollino M.... Neri G. (Am. J. Hum. Genet. 2003)
    9. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (Cancer Res. 2001)
    10. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. (PubMed id 10199401)1, 2 Yamaguchi Y.... Handa H. (Cell 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7469 HGNC: 12768 AceView: WHSC2 Ensembl:ENSG00000185049 euGenes: HUgn7469
    ECgene: NELFA H-InvDB: NELFA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NELFA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NELFA gene:
    Search GeneIP for patents involving NELFA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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