Aliases for NEK9 Gene
External Ids for NEK9 Gene
Previous GeneCards Identifiers for NEK9 Gene
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
GeneCards Summary for NEK9 Gene
NEK9 (NIMA Related Kinase 9) is a Protein Coding gene. Diseases associated with NEK9 include Nevus Comedonicus and Arthrogryposis, Perthes Disease, And Upward Gaze Palsy. Among its related pathways are Transport of the SLBP independent Mature mRNA and Mitotic Prophase. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK8.
UniProtKB/Swiss-Prot for NEK9 Gene
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.