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NEK9 Gene

protein-coding   GIFtS: 65
GCID: GC14M075548

NIMA-Related Kinase 9

(Previous name: NIMA (never in mitosis gene a)- related kinase 9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NIMA-Related Kinase 91 2     Nek82 3
NIMA (Never In Mitosis Gene A)- Related Kinase 91 2     EC 2.7.11.13 8
Nercc1 Kinase2 3     NERCC12 5
Never In Mitosis A-Related Kinase 92 3     NIMA-Related Kinase Nek82
NimA-Related Kinase 82 3     Serine/Threonine-Protein Kinase Nek92
NimA-Related Protein Kinase 92 3     KIAA19953
NERCC2 3     NEK83

External Ids:    HGNC: 185911   Entrez Gene: 917542   Ensembl: ENSG000001196387   OMIM: 6097985   UniProtKB: Q8TD193   

Export aliases for NEK9 gene to outside databases

Previous GC identifers: GC14M073077 GC14M069365 GC14M073538 GC14M073541 GC14M074618 GC14M055716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEK9 Gene:
NEK9 (NIMA-related kinase 9) is a protein-coding gene. Diseases associated with NEK9 include senior-loken syndrome, and cystic kidney. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase binding. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and
chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2.
Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S
transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the
autoinhibitory functions of Tyr-108 and Tyr-97 respectively

Gene Wiki entry for NEK9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEK9 gene promoter:
         STAT1   AML1a   STAT1beta   STAT5A   CUTL1   Nkx2-5   STAT1alpha   c-Ets-1   YY1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK9 promoter sequence
   Search Chromatin IP Primers for NEK9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEK9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

NEK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075548:  view genomic region     (about GC identifiers)

Start:
75,548,818 bp from pter      End:
75,594,047 bp from pter
Size:
45,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek9  
Size: 979 amino acids; 107168 Da
Cofactor: Magnesium
Subunit: Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6,
NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1;
phosphorylation at Ser-944 strongly reduces DYNLL1 binding
Developmental stage: Expression varied mildly across the cell cycle, with highest expression observed in G1 and
stationary-phase cells
Sequence caution: Sequence=AAD31936.1; Type=Erroneous gene model prediction; Sequence=BAC02704.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NEK9:
3ZKE (3D)        3ZKF (3D)    
Secondary accessions: Q52LK6 Q8NCN0 Q8TCY4 Q9UPI4 Q9Y6S4 Q9Y6S5 Q9Y6S6

Explore the universe of human proteins at neXtProt for NEK9: NX_Q8TD19

Explore proteomics data for NEK9 at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated
    phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro1
  • Ubiquitination2 at Lys327, Lys606, Lys650
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NEK9 (Q8TD19)
     DKILRQK  GTPYYMSPE 


    See NEK9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149107.4  
    ENSEMBL proteins: 
     ENSP00000238616   ENSP00000451604   ENSP00000450943   ENSP00000452537   ENSP00000452544  
    Reactome Protein details: Q8TD19

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 9
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    Selected InterPro protein domains (see all 6):
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR009091 RCC1/BLIP-II
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8TD19

    ProtoNet protein and cluster: Q8TD19

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Domain: Dimerizes through its coiled-coil domain
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 6 RCC1 repeats


    NEK9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK9_HUMAN, Q8TD19
    Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and
    chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2.
    Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S
    transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the
    autoinhibitory functions of Tyr-108 and Tyr-97 respectively
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated during mitosis by intramolecular autophosphorylation. Activity and
    autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of
    detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    NEK9 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for NEK9:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Increased Salmonella enterica   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEK9
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    miRNA
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    miRTarBase miRNAs that target NEK9:
    hsa-mir-124-3p (MIRT002635), hsa-let-7b-5p (MIRT052110), hsa-mir-26b-5p (MIRT029337), hsa-mir-324-3p (MIRT042950), hsa-mir-615-3p (MIRT040420)

    Block miRNA regulation of human, mouse, rat NEK9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEK9 (see all 69):
    hsa-miR-520e hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNEK9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEK9_HUMAN, Q8TD19: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4
    cytoskeleton2
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion ----
    GO:0005829cytosol TAS--

    NEK9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEK9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly0.77
    Activation of NIMA Kinases NEK9, NEK6, NEK70.00
    Nuclear Envelope Breakdown0.77
    3RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for NEK9
        Nuclear Pore Complex (NPC) Disassembly
    Activation of NIMA Kinases NEK9, NEK6, NEK7



    NEK9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEK9
    Interactions:

        GeneGlobe Interaction Network for NEK9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEK9 (Q8TD191, 2, 3 ENSP000002386164) via UniProtKB, MINT, STRING, and/or I2D (see all 290)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0007077mitotic nuclear envelope disassembly TAS--

    NEK9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEK9

    5 HMDB Compounds for NEK9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEK9 gene: 
    NM_033116.4  

    Unigene Cluster for NEK9:

    NIMA-related kinase 9
    Hs.7200  [show with all ESTs]
    Unigene Representative Sequence: NM_033116
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238616(uc001xrl.3) ENST00000555405(uc001xrj.3) ENST00000557026(uc001xrk.3)
    ENST00000555763 ENST00000556170 ENST00000555537 ENST00000554258 ENST00000557673
    ENST00000555961 ENST00000553823 ENST00000553945
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NEK9 (see all 69):
    hsa-miR-520e hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNEK9 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat NEK9
      QuantiFast Probe-based Assays in human, mouse, rat NEK9

    Additional mRNA sequence: 

    AB082526.1 AK128693.1 AL117502.1 AL832633.2 AL833036.1 AY048580.1 AY080896.1 BC001714.1 
    BC009336.2 BC062742.1 BC093881.1 BC112101.1 L40402.1 

    17 DOTS entries:

    DT.100795741  DT.97800508  DT.40107140  DT.219045  DT.120791357  DT.91756610  DT.91638460  DT.100029539 
    DT.100795744  DT.100795742  DT.102822232  DT.120791516  DT.40126940  DT.95177241  DT.95310804  DT.99959625 
    DT.120791347 

    11 AceView cDNA sequences:

    AI884951 AI859026 BE327500 AI950160 AI199074 AA827006 AI972045 AA625810 
    AW195739 AW339836 AA528182 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                            -                                                                             -                                 
    SP2:                          -                 -                                                                                                               
    SP3:                                -           -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:        -           -                             -               
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                  -               
    SP5:                                                                  


    ECgene alternative splicing isoforms for NEK9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEK9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGATGG
    NEK9 Expression
    About this image

    NEK9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEK9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7200

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and
    fibroblasts

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEK9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek91 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 90.31(n)1
    95.7(a)1
      12 (39.63 cM)5
    2177181  NM_145138.21  NP_660120.21 
     852995145 
    chicken
    (Gallus gallus)
    Aves NEK91 NIMA (never in mitosis gene a)- related kinase 9 79.28(n)
    86.34(a)
      428891  XM_001235084.3  XP_001235085.3 
    lizard
    (Anolis carolinensis)
    Reptilia NEK96
    NIMA-related kinase 9
    81(a)
    1 ↔ 1
    1(22561407-22593310)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986002 NIMA-family kinase Nercc1 75.97(n)    BC044295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003343611 serine/threonine-protein kinase Nek9-like 59.37(n)
    55.9(a)
      100334361  XM_002665272.3  XP_002665318.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN36
    Nonessential serine/threonine protein kinase; poss...
    25(a)
    1 → many
    I(170396-171703) YAR018C


    ENSEMBL Gene Tree for NEK9 (if available)
    TreeFam Gene Tree for NEK9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEK9 gene
    NEK42  NEK62  NEK12  NEK112  NEK32  NEK72  NEK52  NEK22  
    NEK82  NEK102  
    Selected SIMAP similar genes for NEK9 using alignment to 7 protein entries:     NEK9_HUMAN (see all proteins) (see all similar genes):
    NEK3    MAP2K1    MST094    CDK11B    MAPK4    DKFZp564L2416
    STK25    MOK    NLK    PAK4    NEK8    MAP3K4
    MAPK3    MAPK7    MINK1    ULK1    NEK6    BRAF

    NEK9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEK9 (see all 944)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409274
    A lung neuroendocrine carcinoma sample4--see VAR_0409272 P S mis40--------
    rs747268641,2
    C,F--75548385(+) AATGCT/GCAGCC 1 -- int11Minor allele frequency- G:0.17WA 118
    rs1873130551,2
    C--75548581(+) ACTTTC/TGGCAC 1 -- int10--------
    rs125904521,2
    C,F,A,H--75548756(+) GAGGCC/TTAGAA 1 -- int113Minor allele frequency- T:0.45NA WA CSA EA 514
    rs1913560901,2
    --75548763(+) AGAATA/CTGGAT 1 -- int10--------
    rs1157499731,2
    C,F--75548887(+) TCAAGC/AAACCT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1845847231,2
    --75548931(+) TTAGAA/GCAGAG 1 -- ut310--------
    rs125904981,2
    C,F,H--75548944(+) GTAACT/GCAGGT 1 -- ut31 ese310Minor allele frequency- G:0.08NS EA NA 872
    rs96721,2
    H--75548967(+) CAAAAG/ACAATM 1 -- ut315Minor allele frequency- A:0.02MN NS EA 602
    rs32111071,2
    F--75549005(-) TCTTTA/TTGCAG 1 -- ut311Minor allele frequency- T:0.03MN 184

    HapMap Linkage Disequilibrium report for NEK9 (75548818 - 75594047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NEK9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832833CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NEK9
    DNA2.0 Custom Variant and Variant Library Synthesis for NEK9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609798    OMIM disorders: --

    6 diseases for NEK9:    About MalaCards
    senior-loken syndrome    cystic kidney    nephronophthisis    kidney disease
    polycystic kidney disease    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for NEK9:
    Nephronophthisis     Polycystic kidney disease     Cystic kidney

    NEK9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEK9
    Human Genome Epidemiology (HuGE) Navigator: NEK9 (2 documents)

    Export disorders for NEK9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEK9 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with NEK9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PubMed id 11864968)1, 2, 3, 9 Holland P.M.... Virca G.D. (J. Biol. Chem. 2002)
    2. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)1, 2, 9 Richards M.W.... Bayliss R. (Mol. Cell 2009)
    3. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. (PubMed id 23482567)1, 2 Gallego P.... Reverter D. (J. Biol. Chem. 2013)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    5. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2 Rapley J.... Roig J. (J. Cell Sci. 2008)
    6. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    9. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. (PubMed id 12840024)1, 2 Belham C....Avruch J. (J. Biol. Chem. 2003)
    10. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. (PubMed id 12101123)1, 2 Roig J.... Avruch J. (Genes Dev. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91754 HGNC: 18591 AceView: NEK9.1 Ensembl:ENSG00000119638 euGenes: HUgn91754
    ECgene: NEK9 H-InvDB: NEK9

    (According to HUGE)
    About This Section

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    HUGE: KIAA1995

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEK9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEK9 gene:
    Search GeneIP for patents involving NEK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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