Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEK9 Gene

Aliases for NEK9 Gene

  • NIMA Related Kinase 9 2 3
  • NIMA (Never In Mitosis Gene A)- Related Kinase 9 2 3
  • Never In Mitosis A-Related Kinase 9 3 4
  • NimA-Related Protein Kinase 9 3 4
  • NIMA-Related Kinase 8 3 4
  • NIMA-Related Kinase 9 3 5
  • Nercc1 Kinase 3 4
  • EC 2.7.11.1 4 63
  • NERCC 3 4
  • Nek8 3 4
  • NIMA-Related Kinase Nek8 3
  • KIAA1995 4
  • NERCC1 3

External Ids for NEK9 Gene

Previous GeneCards Identifiers for NEK9 Gene

  • GC14M073077
  • GC14M069365
  • GC14M073538
  • GC14M073541
  • GC14M074618
  • GC14M075548
  • GC14M055716

Summaries for NEK9 Gene

GeneCards Summary for NEK9 Gene

NEK9 (NIMA Related Kinase 9) is a Protein Coding gene. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Mitotic Prophase. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK9 Gene

  • Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Gene Wiki entry for NEK9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK9 Gene

Genomics for NEK9 Gene

Regulatory Elements for NEK9 Gene

Promoters for NEK9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEK9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK9 Gene

Chromosome:
14
Start:
75,079,353 bp from pter
End:
75,127,344 bp from pter
Size:
47,992 bases
Orientation:
Minus strand

Genomic View for NEK9 Gene

Genes around NEK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK9 Gene

Proteins for NEK9 Gene

  • Protein details for NEK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD19-NEK9_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek9
    Protein Accession:
    Q8TD19
    Secondary Accessions:
    • Q52LK6
    • Q8NCN0
    • Q8TCY4
    • Q9UPI4
    • Q9Y6S4
    • Q9Y6S5
    • Q9Y6S6

    Protein attributes for NEK9 Gene

    Size:
    979 amino acids
    Molecular mass:
    107168 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1; phosphorylation at Ser-944 strongly reduces DYNLL1 binding.
    SequenceCaution:
    • Sequence=AAD31936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC02704.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEK9 Gene

neXtProt entry for NEK9 Gene

Proteomics data for NEK9 Gene at MOPED

Selected DME Specific Peptides for NEK9 Gene

Post-translational modifications for NEK9 Gene

  • Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro.
  • Ubiquitination at Lys 327, Lys 606, and Lys 650
  • Modification sites at PhosphoSitePlus

Other Protein References for NEK9 Gene

Antibody Products

Domains & Families for NEK9 Gene

Gene Families for NEK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD19

UniProtKB/Swiss-Prot:

NEK9_HUMAN :
  • Dimerizes through its coiled-coil domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
  • Contains 6 RCC1 repeats.
Domain:
  • Dimerizes through its coiled-coil domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Similarity:
  • Contains 6 RCC1 repeats.
genes like me logo Genes that share domains with NEK9: view

Function for NEK9 Gene

Molecular function for NEK9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells.
UniProtKB/Swiss-Prot Function:
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Enzyme Numbers (IUBMB) for NEK9 Gene

Gene Ontology (GO) - Molecular Function for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK9: view
genes like me logo Genes that share phenotypes with NEK9: view

Animal Models for NEK9 Gene

MGI Knock Outs for NEK9:
  • Nek9 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK9

miRNA for NEK9 Gene

miRTarBase miRNAs that target NEK9

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEK9 Gene

Localization for NEK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK9 Gene COMPARTMENTS Subcellular localization image for NEK9 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
mitochondrion 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with NEK9: view

Pathways & Interactions for NEK9 Gene

genes like me logo Genes that share pathways with NEK9: view

Pathways by source for NEK9 Gene

SIGNOR curated interactions for NEK9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IBA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NEK9: view

Drugs & Compounds for NEK9 Gene

(4) Drugs for NEK9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
Manganese Pharma 32
Magnesium Nutra 0

(1) Additional Compounds for NEK9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK9: view

Transcripts for NEK9 Gene

mRNA/cDNA for NEK9 Gene

Unigene Clusters for NEK9 Gene

NIMA-related kinase 9:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:

Relevant External Links for NEK9 Gene

GeneLoc Exon Structure for
NEK9
ECgene alternative splicing isoforms for
NEK9

Expression for NEK9 Gene

mRNA expression in normal human tissues for NEK9 Gene

Protein differential expression in normal tissues from HIPED for NEK9 Gene

This gene is overexpressed in Lymph node (15.4) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK9 Gene



SOURCE GeneReport for Unigene cluster for NEK9 Gene Hs.7200

mRNA Expression by UniProt/SwissProt for NEK9 Gene

Q8TD19-NEK9_HUMAN
Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
genes like me logo Genes that share expression patterns with NEK9: view

Protein tissue co-expression partners for NEK9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NEK9 Gene

Orthologs for NEK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK9 35
  • 99.47 (n)
  • 99.68 (a)
NEK9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK9 36
  • 95 (a)
OneToOne
NEK9 35
  • 92.73 (n)
  • 96.32 (a)
dog
(Canis familiaris)
Mammalia NEK9 35
  • 93.99 (n)
  • 96.62 (a)
NEK9 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek9 36
  • 95 (a)
OneToOne
Nek9 16
Nek9 35
  • 90.31 (n)
  • 95.7 (a)
oppossum
(Monodelphis domestica)
Mammalia NEK9 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK9 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek9 35
  • 90.39 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves NEK9 36
  • 76 (a)
OneToOne
NEK9 35
  • 79.28 (n)
  • 86.34 (a)
lizard
(Anolis carolinensis)
Reptilia NEK9 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398600 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nek9 35
  • 70.15 (n)
  • 74.86 (a)
Str.2930 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334361 35
  • 59.37 (n)
  • 55.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10951 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 36
  • 25 (a)
OneToMany
Species with no ortholog for NEK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK9 Gene

ENSEMBL:
Gene Tree for NEK9 (if available)
TreeFam:
Gene Tree for NEK9 (if available)

Paralogs for NEK9 Gene

Paralogs for NEK9 Gene

genes like me logo Genes that share paralogs with NEK9: view

Variants for NEK9 Gene

Sequence variations from dbSNP and Humsavar for NEK9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10146482 - 75,107,384(+) CCTGA(C/T)GGATA reference, missense
rs36014869 - 75,088,602(+) AGATG(G/T)GCTGT reference, missense
VAR_040927 A lung neuroendocrine carcinoma sample
rs175447 -- 75,124,698(+) TAAGA(A/G)AAGTC intron-variant
rs175454 -- 75,120,648(+) ACACA(C/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK9 Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV Gain 17160897

Variation tolerance for NEK9 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK9 Gene

HapMap Linkage Disequilibrium report
NEK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK9 Gene

Disorders for NEK9 Gene

Relevant External Links for NEK9

Genetic Association Database (GAD)
NEK9
Human Genome Epidemiology (HuGE) Navigator
NEK9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK9

No disorders were found for NEK9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK9 Gene

Publications for NEK9 Gene

  1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PMID: 11864968) Holland P.M. … Virca G.D. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PMID: 19941817) Richards M.W. … Bayliss R. (Mol. Cell 2009) 3 23
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NEK9 Gene

Sources for NEK9 Gene

Back to Top

Content