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Aliases for NEK9 Gene

Aliases for NEK9 Gene

  • NIMA-Related Kinase 9 2 3
  • NIMA (Never In Mitosis Gene A)- Related Kinase 9 2 3
  • Never In Mitosis A-Related Kinase 9 3 4
  • NimA-Related Protein Kinase 9 3 4
  • NimA-Related Kinase 8 3 4
  • Nercc1 Kinase 3 4
  • EC 2.7.11.1 4 63
  • NERCC1 3 6
  • NERCC 3 4
  • Nek8 3 4
  • Serine/Threonine-Protein Kinase Nek9 3
  • NIMA-Related Kinase Nek8 3
  • KIAA1995 4

External Ids for NEK9 Gene

Previous GeneCards Identifiers for NEK9 Gene

  • GC14M073077
  • GC14M069365
  • GC14M073538
  • GC14M073541
  • GC14M074618
  • GC14M075548
  • GC14M055716

Summaries for NEK9 Gene

GeneCards Summary for NEK9 Gene

NEK9 (NIMA-Related Kinase 9) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase binding. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK9 Gene

  • Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Gene Wiki entry for NEK9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK9 Gene

Genomics for NEK9 Gene

Regulatory Elements for NEK9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NEK9 Gene

Start:
75,079,353 bp from pter
End:
75,127,344 bp from pter
Size:
47,992 bases
Orientation:
Minus strand

Genomic View for NEK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK9 Gene

Proteins for NEK9 Gene

  • Protein details for NEK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD19-NEK9_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek9
    Protein Accession:
    Q8TD19
    Secondary Accessions:
    • Q52LK6
    • Q8NCN0
    • Q8TCY4
    • Q9UPI4
    • Q9Y6S4
    • Q9Y6S5
    • Q9Y6S6

    Protein attributes for NEK9 Gene

    Size:
    979 amino acids
    Molecular mass:
    107168 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1; phosphorylation at Ser-944 strongly reduces DYNLL1 binding.
    SequenceCaution:
    • Sequence=AAD31936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC02704.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEK9 Gene

neXtProt entry for NEK9 Gene

Proteomics data for NEK9 Gene at MOPED

Selected DME Specific Peptides for NEK9 Gene

Post-translational modifications for NEK9 Gene

  • Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro.
  • Ubiquitination at Lys327, Lys606, and Lys650
  • Modification sites at PhosphoSitePlus

Other Protein References for NEK9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NEK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD19

UniProtKB/Swiss-Prot:

NEK9_HUMAN :
  • Q8TD19
Domain:
  • Dimerizes through its coiled-coil domain
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Similarity:
  • Contains 6 RCC1 repeats.
genes like me logo Genes that share domains with NEK9: view

Function for NEK9 Gene

Molecular function for NEK9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells
UniProtKB/Swiss-Prot Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Enzyme Numbers (IUBMB) for NEK9 Gene

Gene Ontology (GO) - Molecular Function for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20562859
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK9: view
genes like me logo Genes that share phenotypes with NEK9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEK9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NEK9 Gene

Localization for NEK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK9 Gene COMPARTMENTS Subcellular localization image for NEK9 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
cytoskeleton 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEK9: view

Pathways for NEK9 Gene

genes like me logo Genes that share pathways with NEK9: view

Pathways by source for NEK9 Gene

Gene Ontology (GO) - Biological Process for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IBA --
GO:0007067 mitotic nuclear division IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NEK9: view

Compounds for NEK9 Gene

(5) HMDB Compounds for NEK9 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Guanosine triphosphate
  • 5'-GTP
86-01-1
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with NEK9: view

Transcripts for NEK9 Gene

mRNA/cDNA for NEK9 Gene

(13) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEK9 Gene

NIMA-related kinase 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEK9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:

Relevant External Links for NEK9 Gene

GeneLoc Exon Structure for
NEK9
ECgene alternative splicing isoforms for
NEK9

Expression for NEK9 Gene

mRNA expression in normal human tissues for NEK9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK9 Gene

SOURCE GeneReport for Unigene cluster for NEK9 Gene Hs.7200

mRNA Expression by UniProt/SwissProt for NEK9 Gene

Q8TD19-NEK9_HUMAN
Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts
genes like me logo Genes that share expressions with NEK9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NEK9 Gene

Orthologs for NEK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK9 35
  • 99.47 (n)
  • 99.68 (a)
NEK9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK9 35
  • 92.73 (n)
  • 96.32 (a)
NEK9 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK9 35
  • 93.99 (n)
  • 96.62 (a)
NEK9 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek9 35
  • 90.31 (n)
  • 95.7 (a)
Nek9 16
Nek9 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK9 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK9 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek9 35
  • 90.39 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves NEK9 35
  • 79.28 (n)
  • 86.34 (a)
NEK9 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK9 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398600 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nek9 35
  • 70.15 (n)
  • 74.86 (a)
Str.2930 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334361 35
  • 59.37 (n)
  • 55.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10951 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 36
  • 25 (a)
OneToMany
Species with no ortholog for NEK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK9 Gene

ENSEMBL:
Gene Tree for NEK9 (if available)
TreeFam:
Gene Tree for NEK9 (if available)

Paralogs for NEK9 Gene

Paralogs for NEK9 Gene

genes like me logo Genes that share paralogs with NEK9: view

Variants for NEK9 Gene

Sequence variations from dbSNP and Humsavar for NEK9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9672 -- 75,082,264(+) CAAAA(A/G)CAATM utr-variant-3-prime
rs10707 -- 75,082,306(+) ATAAA(A/G)AAAAA utr-variant-3-prime
rs11866 -- 75,082,455(+) GTCCC(A/G)GGCAC utr-variant-3-prime
rs96358 -- 75,105,562(+) ATCTG(A/G)TGGTC intron-variant
rs119076 -- 75,105,716(+) AGTAA(G/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK9 Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV Gain 17160897

Relevant External Links for NEK9 Gene

HapMap Linkage Disequilibrium report
NEK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK9 Gene

Disorders for NEK9 Gene

(3) University of Copenhagen DISEASES for NEK9 Gene

Relevant External Links for NEK9

Genetic Association Database (GAD)
NEK9
Human Genome Epidemiology (HuGE) Navigator
NEK9
genes like me logo Genes that share disorders with NEK9: view

No data available for UniProtKB/Swiss-Prot for NEK9 Gene

Publications for NEK9 Gene

  1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PMID: 11864968) Holland P.M. … Virca G.D. (J. Biol. Chem. 2002) 2 3 4 23
  2. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PMID: 19941817) Richards M.W. … Bayliss R. (Mol. Cell 2009) 3 4 23
  3. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 3 4
  4. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. (PMID: 12101123) Roig J. … Avruch J. (Genes Dev. 2002) 3 4
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4

Products for NEK9 Gene

  • Addgene plasmids for NEK9

Sources for NEK9 Gene

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