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Aliases for NEK9 Gene

Aliases for NEK9 Gene

  • NIMA Related Kinase 9 2 3 5
  • NIMA (Never In Mitosis Gene A)- Related Kinase 9 2 3
  • NimA-Related Protein Kinase 9 3 4
  • Nercc1 Kinase 3 4
  • EC 2.7.11.1 4 61
  • NERCC 3 4
  • Serine/Threonine-Protein Kinase Nek9 3
  • Never In Mitosis A-Related Kinase 9 4
  • NimA-Related Kinase 8 4
  • KIAA1995 4
  • LCCS10 3
  • NERCC1 3
  • APUG 3
  • NEK8 4
  • NC 3

External Ids for NEK9 Gene

Previous GeneCards Identifiers for NEK9 Gene

  • GC14M073077
  • GC14M069365
  • GC14M073538
  • GC14M073541
  • GC14M074618
  • GC14M075548
  • GC14M055716

Summaries for NEK9 Gene

Entrez Gene Summary for NEK9 Gene

  • This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEK9 Gene

NEK9 (NIMA Related Kinase 9) is a Protein Coding gene. Diseases associated with NEK9 include Nek9-Related Lethal Skeletal Dysplasia and Nevus Comedonicus. Among its related pathways are Mitotic Prophase and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK8.

UniProtKB/Swiss-Prot for NEK9 Gene

  • Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Gene Wiki entry for NEK9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK9 Gene

Genomics for NEK9 Gene

Regulatory Elements for NEK9 Gene

Enhancers for NEK9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F074647 1.1 Ensembl ENCODE 14.3 +478.7 478702 3.1 ESRRA TAL1 TEAD4 FEZF1 ZIC2 ZNF316 FOXK2 NCOR1 POLR2A PRDM10 FCF1 ELMSAN1 NEK9 LTBP2 ENSG00000258559 AREL1 ENSG00000222604 DLST LOC105370567
GH14F075062 0.6 ENCODE 12.5 +63.4 63420 2.1 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 ZNF143 FOS EIF2B2 NEK9 FCF1 PGF ACYP1 ZC2HC1C MLH3
GH14F075048 0.2 ENCODE 12.5 +76.9 76912 3.3 PKNOX1 CREB3L1 SIN3A YBX1 DMAP1 ZNF48 SLC30A9 ELK1 ZNF143 ZNF207 NEK9 FCF1 EIF2B2 ACYP1 MLH3 RNU6-689P
GH14F074591 1.2 FANTOM5 Ensembl ENCODE 12.3 +531.2 531158 9.6 ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ELK1 PNMA1 LIN52 NEK9 FCF1 ELMSAN1 EIF2B2 AREL1 NPC2 LTBP2 LOC101928352
GH14F075659 0.8 ENCODE 12.3 -533.8 -533757 2.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF143 FLVCR2 RPS2P43 ENSG00000259103 NEK9 FCF1 LOC102724153 TTLL5 IFT43 DPPA5P4 LOC105370571
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NEK9 on UCSC Golden Path with GeneCards custom track

Promoters for NEK9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001458839 544 2401 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 FOS PAF1

Genomic Location for NEK9 Gene

Chromosome:
14
Start:
75,079,353 bp from pter
End:
75,127,344 bp from pter
Size:
47,992 bases
Orientation:
Minus strand

Genomic View for NEK9 Gene

Genes around NEK9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK9 Gene

Proteins for NEK9 Gene

  • Protein details for NEK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD19-NEK9_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek9
    Protein Accession:
    Q8TD19
    Secondary Accessions:
    • Q52LK6
    • Q8NCN0
    • Q8TCY4
    • Q9UPI4
    • Q9Y6S4
    • Q9Y6S5
    • Q9Y6S6

    Protein attributes for NEK9 Gene

    Size:
    979 amino acids
    Molecular mass:
    107168 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1; phosphorylation at Ser-944 strongly reduces DYNLL1 binding.
    SequenceCaution:
    • Sequence=AAD31936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC02704.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEK9 Gene

neXtProt entry for NEK9 Gene

Selected DME Specific Peptides for NEK9 Gene

Post-translational modifications for NEK9 Gene

  • Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro.
  • Ubiquitination at Lys 327, Lys 606, and Lys 650
  • Modification sites at PhosphoSitePlus

Domains & Families for NEK9 Gene

Gene Families for NEK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD19

UniProtKB/Swiss-Prot:

NEK9_HUMAN :
  • Dimerizes through its coiled-coil domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
  • Contains 6 RCC1 repeats.
Domain:
  • Dimerizes through its coiled-coil domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Similarity:
  • Contains 6 RCC1 repeats.
genes like me logo Genes that share domains with NEK9: view

Function for NEK9 Gene

Molecular function for NEK9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells.
UniProtKB/Swiss-Prot Function:
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.

Enzyme Numbers (IUBMB) for NEK9 Gene

Gene Ontology (GO) - Molecular Function for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 20562859
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NEK9: view
genes like me logo Genes that share phenotypes with NEK9: view

Animal Models for NEK9 Gene

MGI Knock Outs for NEK9:
  • Nek9 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK9

miRNA for NEK9 Gene

miRTarBase miRNAs that target NEK9

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEK9

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEK9 Gene

Localization for NEK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK9 Gene COMPARTMENTS Subcellular localization image for NEK9 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
mitochondrion 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005813 centrosome IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEK9: view

Pathways & Interactions for NEK9 Gene

genes like me logo Genes that share pathways with NEK9: view

Pathways by source for NEK9 Gene

SIGNOR curated interactions for NEK9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NEK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA --
GO:0007017 microtubule-based process IBA --
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IBA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with NEK9: view

Drugs & Compounds for NEK9 Gene

(4) Drugs for NEK9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Manganese Approved Nutra 34
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for NEK9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK9: view

Transcripts for NEK9 Gene

mRNA/cDNA for NEK9 Gene

Unigene Clusters for NEK9 Gene

NIMA-related kinase 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEK9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:

Relevant External Links for NEK9 Gene

GeneLoc Exon Structure for
NEK9
ECgene alternative splicing isoforms for
NEK9

Expression for NEK9 Gene

mRNA expression in normal human tissues for NEK9 Gene

Protein differential expression in normal tissues from HIPED for NEK9 Gene

This gene is overexpressed in Lymph node (15.4) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEK9 Gene



Protein tissue co-expression partners for NEK9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEK9 Gene:

NEK9

SOURCE GeneReport for Unigene cluster for NEK9 Gene:

Hs.7200

mRNA Expression by UniProt/SwissProt for NEK9 Gene:

Q8TD19-NEK9_HUMAN
Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
genes like me logo Genes that share expression patterns with NEK9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NEK9 Gene

Orthologs for NEK9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK9 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia NEK9 34 35
  • 93.99 (n)
cow
(Bos Taurus)
Mammalia NEK9 34 35
  • 92.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NEK9 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek9 34
  • 90.39 (n)
mouse
(Mus musculus)
Mammalia Nek9 34 16 35
  • 90.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NEK9 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK9 34 35
  • 79.28 (n)
lizard
(Anolis carolinensis)
Reptilia NEK9 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek9 34
  • 70.15 (n)
Str.2930 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398600 34
zebrafish
(Danio rerio)
Actinopterygii LOC100334361 34
  • 59.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10951 36
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 35
  • 25 (a)
OneToMany
Species where no ortholog for NEK9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK9 Gene

ENSEMBL:
Gene Tree for NEK9 (if available)
TreeFam:
Gene Tree for NEK9 (if available)

Paralogs for NEK9 Gene

Paralogs for NEK9 Gene

genes like me logo Genes that share paralogs with NEK9: view

Variants for NEK9 Gene

Sequence variations from dbSNP and Humsavar for NEK9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_040927 A lung neuroendocrine carcinoma sample
rs142859694 Pathogenic 75,097,231(+) CCAGG(C/T)GGCCA reference, missense
rs757011098 Pathogenic 75,106,541(+) GTTTC(A/G)TGTCA reference, stop-gained
rs879253775 Pathogenic 75,120,534(-) CTGCA(C/T)CCATA reference, missense
rs193920844 Uncertain significance 75,101,741(-) ACACA(-/A)CGTCC reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK9 Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV gain 17160897

Variation tolerance for NEK9 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK9 Gene

Human Gene Mutation Database (HGMD)
NEK9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK9 Gene

Disorders for NEK9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NEK9 Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
nek9-related lethal skeletal dysplasia
  • lethal skeletal dysplasia-fetal akinesia-contractures-thoracic dysplasia-pulmonary hypoplasia syndrome
nevus comedonicus
  • comedo naevus
senior-loken syndrome-1
  • senior-loken syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NEK9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEK9

Genetic Association Database (GAD)
NEK9
Human Genome Epidemiology (HuGE) Navigator
NEK9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK9
genes like me logo Genes that share disorders with NEK9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEK9 Gene

Publications for NEK9 Gene

  1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PMID: 11864968) Holland P.M. … Virca G.D. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PMID: 19941817) Richards M.W. … Bayliss R. (Mol. Cell 2009) 3 4 22 64
  3. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. (PMID: 23482567) Gallego P. … Reverter D. (J. Biol. Chem. 2013) 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PMID: 19001501) Rapley J. … Roig J. (J. Cell Sci. 2008) 3 4 64

Products for NEK9 Gene

Sources for NEK9 Gene

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