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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEK9 Gene

protein-coding   GIFtS: 64
GCID: GC14M075548

NIMA-Related Kinase 9

(Previous name: NIMA (never in mitosis gene a)- related kinase 9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NIMA-Related Kinase 91 2     Nek82 3
NIMA (Never In Mitosis Gene A)- Related Kinase 91 2     EC 2.7.11.13 8
Nercc1 Kinase2 3     NERCC12 5
Never In Mitosis A-Related Kinase 92 3     NIMA-Related Kinase Nek82
NimA-Related Kinase 82 3     Serine/Threonine-Protein Kinase Nek92
NimA-Related Protein Kinase 92 3     KIAA19953
NERCC2 3     NEK83

External Ids:    HGNC: 185911   Entrez Gene: 917542   Ensembl: ENSG000001196387   OMIM: 6097985   UniProtKB: Q8TD193   

Export aliases for NEK9 gene to outside databases

Previous GC identifers: GC14M073077 GC14M069365 GC14M073538 GC14M073541 GC14M074618 GC14M055716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NEK9 Gene: 
NEK9 (NIMA-related kinase 9) is a protein-coding gene. Diseases associated with NEK9 include senior-loken syndrome, and cystic kidney, and among its related super-pathways are Nuclear Envelope Breakdown and Mitotic M-M/G1 phases. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase binding. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and
chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2.
Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S
transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the
autoinhibitory functions of Tyr-108 and Tyr-97 respectively

Gene Wiki entry for NEK9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK9 gene promoter:
         STAT1   AML1a   STAT1beta   STAT5A   CUTL1   Nkx2-5   STAT1alpha   c-Ets-1   YY1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK9 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEK9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

NEK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075548:  view genomic region     (about GC identifiers)

Start:
75,548,818 bp from pter      End:
75,594,047 bp from pter
Size:
45,230 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek9  
Size: 979 amino acids; 107168 Da
Cofactor: Magnesium
Subunit: Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6,
NEK7 and BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex. Interacts with DYNLL1;
phosphorylation at Ser-944 strongly reduces DYNLL1 binding
Subcellular location: Cytoplasm. Nucleus
Developmental stage: Expression varied mildly across the cell cycle, with highest expression observed in G1 and
stationary-phase cells
Sequence caution: Sequence=AAD31936.1; Type=Erroneous gene model prediction; Sequence=BAC02704.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for NEK9:
3ZKE (3D)        3ZKF (3D)    
Secondary accessions: Q52LK6 Q8NCN0 Q8TCY4 Q9UPI4 Q9Y6S4 Q9Y6S5 Q9Y6S6

Explore the universe of human proteins at neXtProt for NEK9: NX_Q8TD19

Explore proteomics data for NEK9 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated
    phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD19

  • 2 DME Specific Peptides for NEK9 (Q8TD19)
     DKILRQK  GTPYYMSPE 

    NEK9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEK9 Protein Expression
    REFSEQ proteins: NP_149107.4  
    ENSEMBL proteins: 
     ENSP00000238616   ENSP00000451604   ENSP00000450943   ENSP00000452537   ENSP00000452544  
    Reactome Protein details: Q8TD19
    Human Recombinant Protein Products for NEK9: 
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    Novus Biologicals NEK9 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEK9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    NEK9 for ontologies           About GeneDecksing



    NEK9 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for NEK9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 9 
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    5/6 InterPro protein domains (see all 6):
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR009091 RCC1/BLIP-II
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TD19

    ProtoNet protein and cluster: Q8TD19

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Domain: Dimerizes through its coiled-coil domain
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 6 RCC1 repeats


    NEK9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK9_HUMAN, Q8TD19
    Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and
    chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2.
    Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S
    transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the
    autoinhibitory functions of Tyr-108 and Tyr-97 respectively
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated during mitosis by intramolecular autophosphorylation. Activity and
    autophosphorylation is activated by manganese >> magnesium ions. Sensitive to increasing concentration of
    detergents. It is not cell-cycle regulated but activity is higher in G0-arrested cells

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    NEK9 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for NEK9:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Increased Salmonella enterica   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEK9 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEK9 
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    hsa-miR-520e hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNEK9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEK9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly0.77
    Mitotic Prophase0.70
    Nuclear Envelope Breakdown0.77
    2M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
    Activation of NIMA Kinases NEK9, NEK6, NEK70.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for NEK9 (see all 8)
        Nuclear Pore Complex (NPC) Disassembly
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases



    NEK9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/279 Interacting proteins for NEK9 (Q8TD191, 2, 3 ENSP000002386164) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0051301cell division IEA--

    NEK9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEK9

    5 HMDB Compounds for NEK9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about NEK9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEK9 gene: 
    NM_033116.4  

    Unigene Cluster for NEK9:

    NIMA-related kinase 9
    Hs.7200  [show with all ESTs]
    Unigene Representative Sequence: NM_033116
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238616(uc001xrl.3) ENST00000555405(uc001xrj.3) ENST00000557026(uc001xrk.3)
    ENST00000555763 ENST00000556170 ENST00000555537 ENST00000554258 ENST00000557673
    ENST00000555961 ENST00000553823 ENST00000553945
    miRNA
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    8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate NEK9 (see all 69):
    hsa-miR-520e hsa-miR-106a hsa-miR-4305 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNEK9 3' UTR sequence
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    Additional mRNA sequence: 

    AB082526.1 AK128693.1 AL117502.1 AL832633.2 AL833036.1 AY048580.1 AY080896.1 BC001714.1 
    BC009336.2 BC062742.1 BC093881.1 BC112101.1 L40402.1 

    17 DOTS entries:

    DT.100795741  DT.97800508  DT.40107140  DT.219045  DT.120791357  DT.91756610  DT.91638460  DT.100029539 
    DT.100795744  DT.100795742  DT.102822232  DT.120791516  DT.40126940  DT.95177241  DT.95310804  DT.99959625 
    DT.120791347 

    11 AceView cDNA sequences:

    BE327500 AI884951 AI859026 AI972045 AI199074 AA827006 AI950160 AW195739 
    AW339836 AA625810 AA528182 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                            -                                                                             -                                 
    SP2:                          -                 -                                                                                                               
    SP3:                                -           -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:        -           -                             -               
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                  -               
    SP5:                                                                  


    ECgene alternative splicing isoforms for NEK9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEK9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGATGG
    NEK9 Expression
    About this image


    See NEK9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEK9

    SOURCE GeneReport for Unigene cluster: Hs.7200

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and
    fibroblasts

        SABiosciences Custom PCR Arrays for NEK9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEK9 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek91 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 90.34(n)1
    95.8(a)1
      12 (39.63 cM)5
    2177181  NM_145138.21  NP_660120.21 
     852995145 
    chicken
    (Gallus gallus)
    Aves NEK91 NIMA (never in mitosis gene a)- related kinase 9 79.15(n)
    86.06(a)
      428891  XM_001235084.2  XP_001235085.2 
    lizard
    (Anolis carolinensis)
    Reptilia NEK96
    Uncharacterized protein
    80(a)
    1 ↔ 1
    1(22561407-22593310)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986002 NIMA-family kinase Nercc1 75.97(n)    BC044295.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN36
    Nonessential serine/threonine protein kinase; poss...
    25(a)
    1 → many
    I(170396-171703)


    ENSEMBL Gene Tree for NEK9 (if available)
    TreeFam Gene Tree for NEK9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEK9 gene
    NEK42  NEK62  NEK12  NEK112  NEK32  NEK72  NEK52  NEK22  
    NEK82  NEK102  
    18/95 SIMAP similar genes for NEK9 using alignment to 7 protein entries:     NEK9_HUMAN (see all proteins) (see all similar genes):
    NEK5    NEK3    MAP2K1    MST094    CDK11B    MAPK4
    DKFZp564L2416    STK25    MOK    NLK    PAK4    NEK8
    MAP3K4    MAPK3    MAPK7    MINK1    ULK1    NEK6

    NEK9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/944 SNPs in NEK9 are shown (see all 944)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409274
    A lung neuroendocrine carcinoma sample4--see VAR_0409272 P S mis40--------
    rs747268641,2
    C,F--75548385(+) AATGCT/GCAGCC 1 -- int11Minor allele frequency- G:0.17WA 118
    rs1873130551,2
    C--75548581(+) ACTTTC/TGGCAC 1 -- int10--------
    rs125904521,2
    C,F,A,H--75548756(+) GAGGCC/TTAGAA 1 -- int113Minor allele frequency- T:0.45NA WA CSA EA 514
    rs1913560901,2
    --75548763(+) AGAATA/CTGGAT 1 -- int10--------
    rs1157499731,2
    C,F--75548887(+) TCAAGC/AAACCT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1845847231,2
    --75548931(+) TTAGAA/GCAGAG 1 -- ut310--------
    rs125904981,2
    C,F,H--75548944(+) GTAACT/GCAGGT 1 -- ut31 ese310Minor allele frequency- G:0.08NS EA NA 872
    rs96721,2
    H--75548967(+) CAAAAG/ACAATM 1 -- ut315Minor allele frequency- A:0.02MN NS EA 602
    rs32111071,2
    F--75549005(-) TCTTTA/TTGCAG 1 -- ut311Minor allele frequency- T:0.03MN 184

    HapMap Linkage Disequilibrium report for NEK9 (75548818 - 75594047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NEK9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832833CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609798    OMIM disorders: --

    6 diseases for NEK9:    About MalaCards
    senior-loken syndrome    cystic kidney    nephronophthisis    kidney disease
    polycystic kidney disease    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for NEK9:
    Nephronophthisis     Polycystic kidney disease     Cystic kidney

    NEK9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEK9
    Human Genome Epidemiology (HuGE) Navigator: NEK9 (2 documents)

    Export disorders for NEK9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEK9 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with NEK9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PubMed id 11864968)1, 2, 3, 9 Holland P.M.... Virca G.D. (2002)
    2. An autoinhibitory tyrosine motif in the cell-cycle-re gulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)1, 2, 9 Richards M.W....Bayliss R. (2009)
    3. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. (PubMed id 23482567)1, 2 Gallego P.... Reverter D. (2013)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    5. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2 Rapley J....Roig J. (2008)
    6. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    9. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. (PubMed id 12840024)1, 2 Belham C....Avruch J. (2003)
    10. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. (PubMed id 12101123)1, 2 Roig J.... Avruch J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91754 HGNC: 18591 AceView: NEK9.1 Ensembl:ENSG00000119638 euGenes: HUgn91754
    ECgene: NEK9 H-InvDB: NEK9

    (According to HUGE)
    About This Section
    HUGE: KIAA1995

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEK9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEK9 gene:
    Search GeneIP for patents involving NEK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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