Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEK8 Gene

protein-coding   GIFtS: 57
GCID: GC17P027068

NIMA-Related Kinase 8

(Previous name: NIMA (never in mitosis gene a)- related kinase 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NIMA-Related Kinase 81 2     RHPD22
JCK2 3 5     Nephrocystin 92
NIMA (Never In Mitosis Gene A)- Related Kinase 81 2     NIMA-Family Kinase NEK82
Never In Mitosis A-Related Kinase 82 3     NIMA-Related Kinase 12a2
Nima-Related Protein Kinase 12a2 3     Serine/Threonine-Protein Kinase Nek82
NimA-Related Protein Kinase 82 3     Serine/Thrionine-Protein Kinase NEK82
NEK12A2 3     EC 2.7.11.13
NPHP92 5     EC 2.7.118

External Ids:    HGNC: 133871   Entrez Gene: 2840862   Ensembl: ENSG000001606027   OMIM: 6097995   UniProtKB: Q86SG63   

Export aliases for NEK8 gene to outside databases

Previous GC identifers: GC00U991210 GC17P026917 GC17P027201 GC17P024079 GC17P027055 GC17P023264 GC17P027059


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEK8 Gene:
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene
A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.
Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile
autosomal recessive form of polycystic kidney disease in humans. (provided by RefSeq, Jul 2008)

GeneCards Summary for NEK8 Gene: 
NEK8 (NIMA-related kinase 8) is a protein-coding gene. Diseases associated with NEK8 include phyllode tumor, and nephronophthisis 9. GO annotations related to this gene include protein serine/threonine kinase activity and metal ion binding. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK8_HUMAN, Q86SG6
Function: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule
epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity)

Gene Wiki entry for NEK8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK8 gene promoter:
         AP-1   ATF-2   Tal-1beta   C/EBPalpha   E47   CHOP-10   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEK8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.1   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.1

NEK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027068:  view genomic region     (about GC identifiers)

Start:
27,052,915 bp from pter      End:
27,070,473 bp from pter
Size:
17,559 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEK8_HUMAN, Q86SG6 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek8  
Size: 692 amino acids; 74806 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with PKD2; may regulate PKD2 targeting to the cilium (By similarity)
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Cell projection, cilium (By similarity).
Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in
dividing cells
Secondary accessions: A6NIC5 Q14CL7 Q2M1S6 Q8NDH1

Explore the universe of human proteins at neXtProt for NEK8: NX_Q86SG6

Explore proteomics data for NEK8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86SG6

  • 3 DME Specific Peptides for NEK8 (Q86SG6)
     VGRGAFG  YNQKSDI  ILHRDLK 

    NEK8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEK8 Protein Expression
    REFSEQ proteins: NP_835464.1  
    ENSEMBL proteins: 
     ENSP00000467335   ENSP00000466896   ENSP00000268766   ENSP00000465859   ENSP00000466476  

    Human Recombinant Protein Products for NEK8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NEK8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NEK8
    GenScript Custom Purified and Recombinant Proteins Services for NEK8
    Novus Biologicals NEK8 Proteins
    Novus Biologicals NEK8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEK8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0072372primary cilium ISS--

    NEK8 for ontologies           About GeneDecksing



    NEK8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NEK8
    GenScript Custom Superior Antibodies Services for NEK8
    Novus Biologicals NEK8 Antibodies
    Abcam antibodies for NEK8
    Cloud-Clone Corp. Antibodies for NEK8 
    ThermoFisher Antibodies for NEK8
    LSBio Antibodies in human, mouse, rat for NEK8 

    Assay Products for NEK8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEK8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEK8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEK8 
    Cloud-Clone Corp. CLIAs for NEK8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 8 
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR009091 RCC1/BLIP-II

    Graphical View of Domain Structure for InterPro Entry Q86SG6

    ProtoNet protein and cluster: Q86SG6

    UniProtKB/Swiss-Prot: NEK8_HUMAN, Q86SG6
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 5 RCC1 repeats


    NEK8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK8_HUMAN, Q86SG6
    Function: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule
    epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    NEK8 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for NEK8:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased substrate adherent c 
     Decreased telomerase activity  Gemcitabine induced cell-death  Increased apoptosis  Increased gamma-H2AX phosphory 
     Stronger migration  Synthetic lethal with cisplati 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nek8):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  mortality/aging 
     renal/urinary system  respiratory system 

    NEK8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nek8tm1Bei for NEK8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEK8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEK8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEK8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEK8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEK8
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NEK8 (see all 11):
    hsa-miR-576-5p hsa-miR-4263 hsa-miR-520a-5p hsa-miR-3926 hsa-miR-2115 hsa-miR-525-5p hsa-miR-3150b-3p hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidNEK8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEK8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEK8
    Sirion Biotech Customized adenovirus for overexpression of NEK8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEK8 (see all 6)
    OriGene ORF clones in mouse, rat for NEK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEK8 (NM_178170)
    Sino Biological Human cDNA Clone for NEK8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK8
    Sirion Biotech Customized lentivirus for stable overexpression of NEK8 
                         Customized lentivirus expression plasmids for stable overexpression of NEK8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NEK8
    Search LifeMap BioReagents cell lines for NEK8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for NEK8 (Q86SG62, 3 ENSP000002687664) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110575 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111415 I2D: score=3 STRING: ENSP00000357656
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    BICD2Q8TD163, ENSP000003493514I2D: score=1 STRING: ENSP00000349351
    CSN2P058143, ENSP000003410304I2D: score=1 STRING: ENSP00000341030
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0009887organ morphogenesis IMP--
    GO:0035330regulation of hippo signaling cascade IDA--

    NEK8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEK8

    3 HMDB Compounds for NEK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about NEK8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEK8 gene: 
    NM_178170.2  

    Unigene Cluster for NEK8:

    NIMA-related kinase 8
    Hs.448468  [show with all ESTs]
    Unigene Representative Sequence: NM_178170
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579671 ENST00000584342 ENST00000579060 ENST00000268766(uc002hcp.3)
    ENST00000543014 ENST00000581000 ENST00000593261 ENST00000592510
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEK8
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NEK8 (see all 11):
    hsa-miR-576-5p hsa-miR-4263 hsa-miR-520a-5p hsa-miR-3926 hsa-miR-2115 hsa-miR-525-5p hsa-miR-3150b-3p hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidNEK8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEK8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK8
    Clone
    Products:
         
    OriGene clones in human, mouse for NEK8 (see all 6)
    OriGene ORF clones in mouse, rat for NEK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEK8 (NM_178170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK8
    Sirion Biotech Customized lentivirus for stable overexpression of NEK8 
                         Customized lentivirus expression plasmids for stable overexpression of NEK8 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEK8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEK8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK8

    Additional mRNA sequence: 

    AK301429.1 AL833909.1 AY242354.1 AY267371.1 BC112240.1 BC113705.1 

    4 DOTS entries:

    DT.40258063  DT.120945084  DT.40304814  DT.91991104 

    24/26 AceView cDNA sequences (see all 26):

    AY267371 NM_178170 AY242354 AI225141 AL833909 CN484712 BX283567 AI432103 
    BU528160 BU615791 BG755480 BF795289 BE905215 AI086865 BF982335 BG329906 
    BG394326 AA355597 AA311846 AA076408 BU194195 AW967280 AA076459 AW391942 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NEK8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                          -     -                                                         
    SP2:                                                                                                                                          
    SP3:                                      -     -                                                                                             
    SP4:              -     -                                                                                                                     
    SP5:                    -                                                                                                                     


    ECgene alternative splicing isoforms for NEK8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTATCAGG
    NEK8 Expression
    About this image


    See NEK8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEK8

    SOURCE GeneReport for Unigene cluster: Hs.448468

    UniProtKB/Swiss-Prot: NEK8_HUMAN, Q86SG6
    Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus.
    Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in
    mucinous adenocarcinoma

        SABiosciences Expression via Pathway-Focused PCR Array including NEK8: 
              Primary Cilia in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NEK8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEK8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEK8 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek81 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 87.76(n)1
    94.22(a)1
      11 (46.74 cM)5
    1408591  NM_080849.31  NP_543125.11 
     781661065 
    chicken
    (Gallus gallus)
    Aves NEK81 NIMA (never in mitosis gene a)- related kinase 8 75.39(n)
    81.1(a)
      417576  XM_415822.3  XP_415822.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200742 Xenopus laevis transcribed sequence with weak similarity more 79.17(n)    BU911952.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nek82 NIMA (never in mitosis gene a)-related kinase 8 77.54(n)   171094  AF407580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta niki1 nimA-like kinase 47.92(n)
    36.23(a)
      42959  NM_143036.1  NP_651293.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nekl-11 Protein NEKL-1 46.47(n)
    39.25(a)
      189769  NM_058567.2  NP_490968.2 


    ENSEMBL Gene Tree for NEK8 (if available)
    TreeFam Gene Tree for NEK8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEK8 gene
    NEK42  NEK62  NEK12  NEK112  NEK32  NEK72  NEK52  NEK22  
    NEK102  NEK92  
    18/48 SIMAP similar genes for NEK8 using alignment to 5 protein entries:     NEK8_HUMAN (see all proteins) (see all similar genes):
    NEK5    NEK3    DKFZp564L2416    NEK6    MAPK3    MARK2
    NEK4    PHKG2    SGK494    NEK7    PRKD3    NEK9
    STK36    BRAF    STK25    MARK4    CDK7    KIN27

    NEK8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/355 SNPs in NEK8 are shown (see all 355)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0657714
    Nephronophthisis 9 (NPHP9)4--see VAR_0657712 A P mis40--------
    VAR_0657704
    Nephronophthisis 9 (NPHP9)4--see VAR_0657702 H Y mis40--------
    VAR_0657694
    Nephronophthisis 9 (NPHP9)4--see VAR_0657692 L F mis40--------
    rs105324841,2
    C--27056551(+) TTTTT-/TTTGAGGC 2 -- int1 cds11Minor allele frequency- TTT:0.00NA 2
    rs1121555681,2
    F--27063931(+) AACATG/ATAAGT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1116514941,2
    C--27114093(+) TGTGGC/GGCGGG 1 -- us2k10--------
    rs1416210001,2
    C--27114134(+) GCTTT-/CGGGGA 1 -- us2k10--------
    rs1861486561,2
    --27114566(+) CCTTGA/CGAGAG 1 -- us2k10--------
    rs116582331,2
    C,F,H--27114643(+) GCTAAC/ACTTCA 1 -- us2k15Minor allele frequency- A:0.01NS NA 504
    rs665163761,2
    C--27114691(+) TCTTT-/CTTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEK8 (27052915 - 27070473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NEK8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908028CNV Loss21882294
    esv24071CNV Loss19812545


    Human Gene Mutation Database (HGMD): NEK8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NEK8
    DNA2.0 Custom Variant and Variant Library Synthesis for NEK8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609799    OMIM disorders: --

    UniProtKB/Swiss-Prot: NEK8_HUMAN, Q86SG6
  • Nephronophthisis 9 (NPHP9) [MIM:613824]: An autosomal recessive disorder resulting in end-stage renal
    disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of
    the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages,
    medullary cysts. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for NEK8:    About MalaCards
    phyllode tumor    nephronophthisis 9    breast malignant phyllodes tumor    gallbladder small cell carcinoma
    jaw cancer    small cell carcinoma    polycystic kidney disease    senior-loken syndrome
    mucinous adenocarcinoma    nephronophthisis    cystic kidney    kidney disease
    adenocarcinoma    thyroiditis

    5 diseases from the University of Copenhagen DISEASES database for NEK8:
    Nephronophthisis     Cystic kidney     Polycystic kidney disease     Jaw cancer
    Breast malignant phyllodes tumor

    NEK8 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: NEK8 (3 documents)

    Export disorders for NEK8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEK8 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with NEK8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. (PubMed id 18199800)1, 2, 3 Otto E.A....Hildebrandt F. (2008)
    2. Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. (PubMed id 15019993)1, 2 Bowers A.J. and Boylan J.F. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    5. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    6. The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ. (PubMed id 23026745)1 Habbig S....Schermer B. (2012)
    7. The Nek8 protein kinase, mutated in the human cystic k idney disease nephronophthisis, is both activated and degraded during ciliogenes is. (PubMed id 22106379)1 Zalli D....Fry A.M. (2012)
    8. Mutation analysis of 18 nephronophthisis associated c iliopathy disease genes using a DNA pooling and next generation sequencing stra tegy. (PubMed id 21068128)1 Otto E.A....Hildebrandt F. (2010)
    9. Nephronophthisis. (PubMed id 19066617)1 Simms R.J....Sayer J.A. (2009)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284086 HGNC: 13387 AceView: NEK8 Ensembl:ENSG00000160602 euGenes: HUgn284086
    ECgene: NEK8 H-InvDB: NEK8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEK8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEK8 gene:
    Search GeneIP for patents involving NEK8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NEK8  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NEK8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NEK8  
     OriGene qSTAR qPCR primer pairs in human, mouse for NEK8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NEK8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEK8   OriGene Custom Protein Services for NEK8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEK8
     QIAGEN SeqTarget long-range PCR primers for resequencing NEK8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK8
     GenScript Custom Purified and Recombinant Proteins Services for NEK8 GenScript cDNA clones with any tag delivered in your preferred vector for NEK8
     GenScript Custom Assay Services for NEK8 GenScript Custom Superior Antibodies Services for NEK8
     GenScript Custom overexpressing Cell Line Services for NEK8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEK8 promoter
     Search Chromatin IP Primers for NEK8
     RT2 qPCR Primer Assay in human, mouse, rat NEK8
     Search GNC Networks for NEK8
     SABiosciences PCR Arrays including human, mouse, rat NEK8
     Search Tocris compounds for NEK8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NEK8
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEK8 antibodies
     NEK8 proteins
     NEK8 lysates
     Antibodies for NEK8
     See all of Abcam's Antibodies, Kits and Proteins for NEK8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NEK8
     Antibodies for NEK8
     ELISAs for NEK8
     CLIAs for NEK8
     Search LifeMap BioReagents cell lines for NEK8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK8
     SwitchGear 3'UTR luciferase reporter plasmids for NEK8
     SwitchGear Promoter luciferase reporter plasmids for NEK8
     ThermoFisher Antibodies for NEK8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NEK8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEK8
    Customized:
     lentivirus for stable overexpression of NEK8
     lentivirus expression plasmids for stable overexpression of NEK8
     adenovirus for overexpression of NEK8
     LSBio Antibodies in human, mouse, rat for NEK8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NEK8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4