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Aliases for NEK7 Gene

Aliases for NEK7 Gene

  • NIMA Related Kinase 7 2 3 5
  • EC 2.7.11.1 4 61
  • NIMA (Never In Mitosis Gene A)-Related Kinase 7 2
  • Never In Mitosis A-Related Kinase 7 4
  • NimA-Related Protein Kinase 7 4

External Ids for NEK7 Gene

Previous GeneCards Identifiers for NEK7 Gene

  • GC01P195928
  • GC01P193660
  • GC01P194592
  • GC01P195489
  • GC01P195459
  • GC01P194933
  • GC01P196392
  • GC01P169281

Summaries for NEK7 Gene

Entrez Gene Summary for NEK7 Gene

  • NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

GeneCards Summary for NEK7 Gene

NEK7 (NIMA Related Kinase 7) is a Protein Coding gene. Diseases associated with NEK7 include Gallbladder Cancer. Among its related pathways are Transport of the SLBP independent Mature mRNA and Mitotic Prophase. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK6.

UniProtKB/Swiss-Prot for NEK7 Gene

  • Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK7 Gene

Genomics for NEK7 Gene

Regulatory Elements for NEK7 Gene

Enhancers for NEK7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G198185 1.6 Ensembl ENCODE dbSUPER 12.5 +30.6 30610 4.7 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 NEK7 GC01M198198
GH01G198177 1.3 Ensembl ENCODE dbSUPER 11.9 +22.4 22389 4.3 ZSCAN4 TAL1 FEZF1 ZNF2 ZNF316 CBX5 ZSCAN5C IKZF2 MAFK ZBTB20 NEK7 GC01M198198
GH01G198190 0.9 dbSUPER 12.5 +33.7 33725 0.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 REST SMARCA4 NBN HMBOX1 NEK7 GC01M198198
GH01G198294 1.9 VISTA 4 +138.6 138560 2.2 PKNOX1 HLF TAL1 DPF2 EP300 TCF12 NFIC POLR2A SMARCA4 PBX2 NEK7 GC01P198285 LOC105371677
GH01G198370 1.5 VISTA 4.7 +214.4 214412 2.2 FOXA2 ZNF512 PRDM10 FOXP2 FOXA1 NEK7 GC01P198285 LOC105371677
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEK7 on UCSC Golden Path with GeneCards custom track

Promoters for NEK7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017721 1037 3601 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for NEK7 Gene

Chromosome:
1
Start:
198,156,963 bp from pter
End:
198,322,420 bp from pter
Size:
165,458 bases
Orientation:
Plus strand

Genomic View for NEK7 Gene

Genes around NEK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK7 Gene

Proteins for NEK7 Gene

  • Protein details for NEK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDX7-NEK7_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek7
    Protein Accession:
    Q8TDX7
    Secondary Accessions:
    • A6NGT8

    Protein attributes for NEK7 Gene

    Size:
    302 amino acids
    Molecular mass:
    34551 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer. Interacts with NEK9.

    Three dimensional structures from OCA and Proteopedia for NEK7 Gene

    Alternative splice isoforms for NEK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK7 Gene

Selected DME Specific Peptides for NEK7 Gene

Q8TDX7:
  • IEKKIGRGQFSEVY
  • GTPYYMSPE
  • FKKQKRLIPERTVWKYFVQLCSA
  • KSDIWSLGC
  • KIEQCDYPPLP
  • KPANVFIT
  • SFIEDNELNIVLELADAGDLS

Post-translational modifications for NEK7 Gene

  • Phosphorylation at Ser-195 required for its activation.
  • Ubiquitination at posLast=7474 and posLast=189189
  • Modification sites at PhosphoSitePlus

Domains & Families for NEK7 Gene

Gene Families for NEK7 Gene

Suggested Antigen Peptide Sequences for NEK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDX7

UniProtKB/Swiss-Prot:

NEK7_HUMAN :
  • Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.
  • The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK7: view

Function for NEK7 Gene

Molecular function for NEK7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.
UniProtKB/Swiss-Prot Function:
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.

Enzyme Numbers (IUBMB) for NEK7 Gene

Gene Ontology (GO) - Molecular Function for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NEK7: view
genes like me logo Genes that share phenotypes with NEK7: view

Animal Models for NEK7 Gene

MGI Knock Outs for NEK7:

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK7

CRISPR Products

miRNA for NEK7 Gene

miRTarBase miRNAs that target NEK7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEK7

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEK7 Gene

Localization for NEK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK7 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with NEK7: view

Pathways & Interactions for NEK7 Gene

genes like me logo Genes that share pathways with NEK7: view

Pathways by source for NEK7 Gene

1 Cell Signaling Technology pathway for NEK7 Gene
1 KEGG pathway for NEK7 Gene

SIGNOR curated interactions for NEK7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis TAS 17727698
GO:0006468 protein phosphorylation IDA,IEA 12840024
GO:0007346 regulation of mitotic cell cycle TAS 17727698
GO:0016310 phosphorylation IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 21531765
genes like me logo Genes that share ontologies with NEK7: view

Drugs & Compounds for NEK7 Gene

(2) Drugs for NEK7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for NEK7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK7: view

Transcripts for NEK7 Gene

Unigene Clusters for NEK7 Gene

NIMA-related kinase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEK7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK7 Gene

No ASD Table

Relevant External Links for NEK7 Gene

GeneLoc Exon Structure for
NEK7
ECgene alternative splicing isoforms for
NEK7

Expression for NEK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEK7 Gene

mRNA differential expression in normal tissues according to GTEx for NEK7 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for NEK7 Gene

This gene is overexpressed in Breast (13.2) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEK7 Gene



Protein tissue co-expression partners for NEK7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEK7 Gene:

NEK7

SOURCE GeneReport for Unigene cluster for NEK7 Gene:

Hs.24119

mRNA Expression by UniProt/SwissProt for NEK7 Gene:

Q8TDX7-NEK7_HUMAN
Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.

Evidence on tissue expression from TISSUES for NEK7 Gene

  • Pancreas(4.2)
  • Nervous system(3.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with NEK7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK7 Gene

Orthologs for NEK7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK7 34 35
  • 99.89 (n)
oppossum
(Monodelphis domestica)
Mammalia NEK7 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK7 34 35
  • 94.92 (n)
cow
(Bos Taurus)
Mammalia NEK7 34 35
  • 91.39 (n)
mouse
(Mus musculus)
Mammalia Nek7 34 16 35
  • 91.28 (n)
rat
(Rattus norvegicus)
Mammalia Nek7 34
  • 91.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NEK7 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK7 34 35
  • 85.98 (n)
lizard
(Anolis carolinensis)
Reptilia NEK7 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek7 34
  • 80.91 (n)
zebrafish
(Danio rerio)
Actinopterygii nek7 34 35
  • 76.43 (n)
worm
(Caenorhabditis elegans)
Secernentea nekl-3 34 35
  • 65.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
OneToMany
Species where no ortholog for NEK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK7 Gene

ENSEMBL:
Gene Tree for NEK7 (if available)
TreeFam:
Gene Tree for NEK7 (if available)

Paralogs for NEK7 Gene

Variants for NEK7 Gene

Sequence variations from dbSNP and Humsavar for NEK7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_040925 An ovarian serous carcinoma sample
rs1000048717 -- 198,193,781(+) AGGTA(C/T)TGAAG intron-variant
rs1000066240 -- 198,320,697(+) ATACT(C/G)TACCT utr-variant-3-prime
rs1000076519 -- 198,288,770(+) GTATG(C/T)CATGC intron-variant
rs1000090231 -- 198,190,505(+) TTTAC(C/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK7 Gene

Variant ID Type Subtype PubMed ID
esv2564043 CNV deletion 19546169
esv3304305 CNV mobile element insertion 20981092
esv3305151 CNV mobile element insertion 20981092
esv3309071 CNV mobile element insertion 20981092
esv3328419 CNV insertion 20981092
esv3588513 CNV loss 21293372
esv3588517 CNV loss 21293372
esv3588519 CNV loss 21293372
esv3588521 CNV loss 21293372
nsv1005959 CNV gain 25217958
nsv1011794 CNV gain 25217958
nsv1141162 CNV duplication 24896259
nsv1145391 CNV deletion 24896259
nsv832248 CNV gain+loss 17160897
nsv946568 CNV duplication 23825009
nsv952635 CNV duplication 24416366

Variation tolerance for NEK7 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK7 Gene

Disorders for NEK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEK7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards
Search NEK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEK7

Genetic Association Database (GAD)
NEK7
Human Genome Epidemiology (HuGE) Navigator
NEK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK7
genes like me logo Genes that share disorders with NEK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEK7 Gene

Publications for NEK7 Gene

  1. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PMID: 11701951) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 2001) 2 3 4 22 64
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  3. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. (PMID: 19414596) O'Regan L. … Fry A.M. (Mol. Cell. Biol. 2009) 3 4 64
  4. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PMID: 19941817) Richards M.W. … Bayliss R. (Mol. Cell 2009) 3 4 64
  5. NEK7 is a centrosomal kinase critical for microtubule nucleation. (PMID: 17586473) Kim S. … Rhee K. (Biochem. Biophys. Res. Commun. 2007) 3 4 64

Products for NEK7 Gene

Sources for NEK7 Gene

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