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Aliases for NEK7 Gene

Aliases for NEK7 Gene

  • NIMA-Related Kinase 7 2 3
  • EC 2.7.11.1 4 63
  • NIMA (Never In Mitosis Gene A)-Related Kinase 7 2
  • Never In Mitosis A-Related Kinase 7 4
  • NimA-Related Protein Kinase 7 4

External Ids for NEK7 Gene

Previous GeneCards Identifiers for NEK7 Gene

  • GC01P195928
  • GC01P193660
  • GC01P194592
  • GC01P195489
  • GC01P195459
  • GC01P194933
  • GC01P196392
  • GC01P169281

Summaries for NEK7 Gene

Entrez Gene Summary for NEK7 Gene

  • NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

GeneCards Summary for NEK7 Gene

NEK7 (NIMA-Related Kinase 7) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK7 Gene

  • Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK7 Gene

Genomics for NEK7 Gene

Regulatory Elements for NEK7 Gene

Genomic Location for NEK7 Gene

Start:
198,156,963 bp from pter
End:
198,322,420 bp from pter
Size:
165,458 bases
Orientation:
Plus strand

Genomic View for NEK7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK7 Gene

Proteins for NEK7 Gene

  • Protein details for NEK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDX7-NEK7_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek7
    Protein Accession:
    Q8TDX7
    Secondary Accessions:
    • A6NGT8

    Protein attributes for NEK7 Gene

    Size:
    302 amino acids
    Molecular mass:
    34551 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer. Interacts with NEK9.

    Three dimensional structures from OCA and Proteopedia for NEK7 Gene

    Alternative splice isoforms for NEK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK7 Gene

Proteomics data for NEK7 Gene at MOPED

Post-translational modifications for NEK7 Gene

  • Phosphorylation at Ser-195 required for its activation.
  • Ubiquitination at Lys74, Lys163, and Lys189
  • Modification sites at PhosphoSitePlus

Other Protein References for NEK7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NEK7 (NEK7)

Domains for NEK7 Gene

Suggested Antigen Peptide Sequences for NEK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDX7

UniProtKB/Swiss-Prot:

NEK7_HUMAN :
  • Q8TDX7
Domain:
  • Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.
  • The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus contributes to activity.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK7: view

Function for NEK7 Gene

Molecular function for NEK7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97.
UniProtKB/Swiss-Prot Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.

Enzyme Numbers (IUBMB) for NEK7 Gene

Gene Ontology (GO) - Molecular Function for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with NEK7: view
genes like me logo Genes that share phenotypes with NEK7: view

Animal Models for NEK7 Gene

MGI Knock Outs for NEK7:

Animal Model Products

CRISPR Products

miRNA for NEK7 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEK7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for NEK7 Gene

Localization for NEK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK7 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK7 Gene COMPARTMENTS Subcellular localization image for NEK7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with NEK7: view

Pathways for NEK7 Gene

genes like me logo Genes that share pathways with NEK7: view

Pathways by source for NEK7 Gene

1 Cell Signaling Technology pathway for NEK7 Gene

Gene Ontology (GO) - Biological Process for NEK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis TAS 17727698
GO:0006468 protein phosphorylation IDA 12840024
GO:0007346 regulation of mitotic cell cycle TAS 17727698
GO:0009966 regulation of signal transduction IEA --
GO:0051225 spindle assembly TAS 17727698
genes like me logo Genes that share ontologies with NEK7: view

Compounds for NEK7 Gene

(3) HMDB Compounds for NEK7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with NEK7: view

Transcripts for NEK7 Gene

Unigene Clusters for NEK7 Gene

NIMA-related kinase 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NEK7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK7 Gene

No ASD Table

Relevant External Links for NEK7 Gene

GeneLoc Exon Structure for
NEK7
ECgene alternative splicing isoforms for
NEK7

Expression for NEK7 Gene

mRNA expression in normal human tissues for NEK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEK7 Gene

This gene is overexpressed in Heart - Left Ventricle (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK7 Gene

SOURCE GeneReport for Unigene cluster for NEK7 Gene Hs.24119

mRNA Expression by UniProt/SwissProt for NEK7 Gene

Q8TDX7-NEK7_HUMAN
Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
genes like me logo Genes that share expressions with NEK7: view

In Situ Assay Products

Orthologs for NEK7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK7 35
  • 99.89 (n)
  • 100 (a)
NEK7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK7 35
  • 91.39 (n)
  • 99.34 (a)
NEK7 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK7 35
  • 94.92 (n)
  • 99.34 (a)
NEK7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek7 35
  • 91.28 (n)
  • 97.68 (a)
Nek7 16
Nek7 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK7 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek7 35
  • 91.06 (n)
  • 98.01 (a)
chicken
(Gallus gallus)
Aves NEK7 35
  • 85.98 (n)
  • 98.01 (a)
NEK7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK7 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek7 35
  • 80.91 (n)
  • 95.03 (a)
zebrafish
(Danio rerio)
Actinopterygii nek7 35
  • 76.43 (n)
  • 88.89 (a)
nek7 36
  • 89 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-3 35
  • 65.79 (n)
  • 75.28 (a)
nekl-3 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for NEK7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK7 Gene

ENSEMBL:
Gene Tree for NEK7 (if available)
TreeFam:
Gene Tree for NEK7 (if available)

Paralogs for NEK7 Gene

Paralogs for NEK7 Gene

genes like me logo Genes that share paralogs with NEK7: view

Variants for NEK7 Gene

Sequence variations from dbSNP and Humsavar for NEK7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2197 -- 198,256,515(+) AACAA(C/T)TTTGA intron-variant
rs716784 -- 198,285,259(-) ATTAC(A/G)AGCAA intron-variant
rs997901 -- 198,283,493(+) TCCTC(C/T)TCCCA intron-variant
rs1061258 -- 198,318,139(-) TTTTA(C/T)GATTC intron-variant
rs1139949 -- 198,320,797(+) GAACT(C/G)TTATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NEK7 Gene

Variant ID Type Subtype PubMed ID
nsv832248 CNV Gain+Loss 17160897
esv269429 CNV Insertion 20981092
esv268584 CNV Insertion 20981092
esv273344 CNV Insertion 20981092
esv2564043 CNV Deletion 19546169

Relevant External Links for NEK7 Gene

HapMap Linkage Disequilibrium report
NEK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK7 Gene

Disorders for NEK7 Gene

Relevant External Links for NEK7

Genetic Association Database (GAD)
NEK7
Human Genome Epidemiology (HuGE) Navigator
NEK7
genes like me logo Genes that share disorders with NEK7: view

No data available for UniProtKB/Swiss-Prot for NEK7 Gene

Publications for NEK7 Gene

  1. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PMID: 11701951) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. (PMID: 12840024) Belham C. … Avruch J. (J. Biol. Chem. 2003) 3 4
  3. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. (PMID: 17101132) Yissachar N. … Motro B. (FEBS Lett. 2006) 3 4
  4. NEK7 is a centrosomal kinase critical for microtubule nucleation. (PMID: 17586473) Kim S. … Rhee K. (Biochem. Biophys. Res. Commun. 2007) 3 4
  5. Mitotic regulation by NIMA-related kinases. (PMID: 17727698) O'regan L. … Fry A.M. (Cell Div. 2007) 3 4

Products for NEK7 Gene

  • Addgene plasmids for NEK7

Sources for NEK7 Gene

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