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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEK7 Gene

protein-coding   GIFtS: 63
GCID: GC01P198126

NIMA-Related Kinase 7

(Previous name: NIMA (never in mitosis gene a)-related kinase 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NIMA-Related Kinase 71 2
NIMA (Never In Mitosis Gene A)-Related Kinase 71 2
Never In Mitosis A-Related Kinase 72 3
NimA-Related Protein Kinase 72 3
EC 2.7.11.13 8
Serine/Threonine-Protein Kinase Nek72

External Ids:    HGNC: 133861   Entrez Gene: 1406092   Ensembl: ENSG000001514147   OMIM: 6068485   UniProtKB: Q8TDX73   

Export aliases for NEK7 gene to outside databases

Previous GC identifers: GC01P195928 GC01P193660 GC01P194592 GC01P195489 GC01P195459 GC01P194933 GC01P196392 GC01P169281


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEK7 Gene:
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans
'never in mitosis A' gene, which controls initiation of mitosis.(supplied by OMIM, Jul 2002)

GeneCards Summary for NEK7 Gene: 
NEK7 (NIMA-related kinase 7) is a protein-coding gene. Diseases associated with NEK7 include polycystic kidney disease, and kidney disease, and among its related super-pathways are Nuclear Envelope Breakdown and Mitotic M-M/G1 phases. GO annotations related to this gene include protein serine/threonine kinase activity and metal ion binding. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule
nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK7 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   ISGF-3   oct-B3   oct-B2   POU2F2   GATA-1   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.3

NEK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P198126:  view genomic region     (about GC identifiers)

Start:
198,126,093 bp from pter      End:
198,291,550 bp from pter
Size:
165,458 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek7  
Size: 302 amino acids; 34551 Da
Cofactor: Magnesium
Subunit: Monomer. Interacts with NEK9
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at
spindle midzone of the anaphase cells and eventually concentrates at the midbody
2 PDB 3D structures from and Proteopedia for NEK7:
2WQM (3D)        2WQN (3D)    
Secondary accessions: A6NGT8
Alternative splicing: 2 isoforms:  Q8TDX7-1   Q8TDX7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK7: NX_Q8TDX7

Explore proteomics data for NEK7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-195 required for its activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDX7

  • 4/7 DME Specific Peptides for NEK7 (Q8TDX7) (see all 7)
     KPANVFIT  KSDIWSLGC  GTPYYMSPE  KIEQCDYPPLP 

    NEK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEK7 Protein Expression
    REFSEQ proteins: NP_598001.1  
    ENSEMBL proteins: 
     ENSP00000356355   ENSP00000392745   ENSP00000444621   ENSP00000356353   ENSP00000439095  
     ENSP00000375835  
    Reactome Protein details: Q8TDX7
    Human Recombinant Protein Products for NEK7: 
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    Sino Biological Recombinant Protein for NEK7
    Sino Biological Cell Lysate for NEK7 
    ProSpec Recombinant Protein for NEK7
    Cloud-Clone Corp. Proteins for NEK7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005874microtubule IEA--

    NEK7 for ontologies           About GeneDecksing



    NEK7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 7 
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TDX7

    ProtoNet protein and cluster: Q8TDX7

    UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
    Domain: Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the
    activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9
    Domain: The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus
    contributes to activity
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    NEK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK7_HUMAN, Q8TDX7
    Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule
    nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    NEK7 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for NEK7:
     Cell division defect  Decreased substrate adherent c  Decreased telomerase activity  Increased G2M DNA content 
     Increased colony dispersion (i  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nek7):
     cellular  growth/size  mortality/aging  vision/eye 

    NEK7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nek7tm1Mot for NEK7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEK7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEK7 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEK7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly0.77
    Mitotic Prophase0.70
    Nuclear Envelope Breakdown0.77
    2M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
    Activation of NIMA Kinases NEK9, NEK6, NEK70.38
    5DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NEK7
        Cell Cycle / Checkpoint Control


    5/8        Reactome Pathways for NEK7 (see all 8)
        Nuclear Pore Complex (NPC) Disassembly
    Mitotic Prophase
    Cell Cycle
    M Phase
    Mitotic M-M/G1 phases



    NEK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NEK7 (Q8TDX73 ENSP000003563554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=2 STRING: ENSP00000362702
    NEK9Q8TD193, ENSP000002386164I2D: score=5 STRING: ENSP00000238616
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS17727698
    GO:0006468protein phosphorylation IDA12840024
    GO:0007346regulation of mitotic cell cycle TAS17727698
    GO:0051225spindle assembly TAS17727698

    NEK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NEK7

    3 HMDB Compounds for NEK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about NEK7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEK7 gene: 
    NM_133494.2  

    Unigene Clusters for NEK7:

    NIMA-related kinase 7
    Hs.24119  [show with all ESTs], Hs.745083  [show with all ESTs]
    Unigene Representative Sequences: NM_133494, BC043003
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367385(uc001gun.4 uc021pgx.1) ENST00000442588 ENST00000538004
    ENST00000367383 ENST00000544035 ENST00000417895 ENST00000391974 ENST00000493790

    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate NEK7 (see all 64):
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    Additional mRNA sequence: BC043003.2 

    8 DOTS entries:

    DT.213680  DT.100022128  DT.100776055  DT.99993701  DT.121364292  DT.95272718  DT.95272719  DT.121364319 

    24/204 AceView cDNA sequences (see all 204):

    AW771141 BF057667 AI279412 BG057502 AA280996 BM974979 CB241962 BQ774293 
    AA102848 AA330074 BQ023360 AW339206 BQ014574 CD677193 BM468972 AA385867 
    AA506352 AA295264 AI361369 BU681351 BE887322 CA390798 BM783345 BQ959234 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEK7 expression in normal human tissues (normalized intensities)      NEK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTTTAC
    NEK7 Expression
    About this image


    NEK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
             brain/midbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Smooth Muscle (Extraembryonic Tissues)
             Human umbilical Smooth Muscle (HUSM)   

    See NEK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEK7

    SOURCE GeneReport for Unigene clusters: Hs.24119 Hs.745083

    UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
    Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower
    expression in ovary, prostate and kidney. No expression seen in small intestine

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEK7 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek71 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 91.28(n)1
    97.68(a)1
      1 (60.82 cM)5
    591251  NM_021605.31  NP_067618.11 
     1384847145 
    chicken
    (Gallus gallus)
    Aves NEK71 NIMA (never in mitosis gene a)-related kinase 7 85.98(n)
    98.01(a)
      424350  NM_001031264.1  NP_001026435.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEK76
    Uncharacterized protein
    96(a)
    1 ↔ 1
    GL343211.1(213841-299458)
    zebrafish
    (Danio rerio)
    Actinopterygii nek71 NIMA (never in mitosis gene a)-related kinase 7 76.43(n)
    88.89(a)
      445223  NM_001003617.1  NP_001003617.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nekl-31 Protein NEKL-3 65.79(n)
    75.28(a)
      181398  NM_077679.4  NP_510080.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN36
    Nonessential serine/threonine protein kinase; poss...
    21(a)
    1 → many
    I(170396-171703)


    ENSEMBL Gene Tree for NEK7 (if available)
    TreeFam Gene Tree for NEK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEK7 gene
    NEK42  NEK62  NEK12  NEK112  NEK32  NEK52  NEK22  NEK82  
    NEK102  NEK92  
    18/47 SIMAP similar genes for NEK7 using alignment to 4 protein entries:     NEK7_HUMAN (see all proteins) (see all similar genes):
    NEK6    NEK1    NEK8    NEK11    NEK5    NEK2
    NEK4    NEK10    NEK3    DKFZp434B079    NEK9    STK25
    YSK4    MAP2K3    MAP3K19    MAP3K2    MAP3K4    OXSR1

    NEK7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3076 SNPs in NEK7 are shown (see all 3076)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409254
    An ovarian serous carcinoma sample4--see VAR_0409252 I M mis40--------
    rs2016760701,2
    Cuntested1198262082(+) GGTACA/GCCTTA 2 T syn10--------
    rs57799061,2
    C--169301164(+) ATATA-/TAATGGG 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1477934711,2
    --198124183(+) GATTTA/GGTCAC 1 -- us2k10--------
    rs1411921741,2
    --198124361(+) AAGCCC/GACTTC 1 -- us2k10--------
    rs1893965641,2
    --198124431(+) CAAATA/GGCTAA 1 -- us2k10--------
    rs125661851,2
    C,F,H--198124475(+) agagaG/Agcatt 1 -- us2k1 tfbs35Minor allele frequency- A:0.01NS EA NA 416
    rs727494741,2
    C,F--198124732(+) CTCCTT/CTTGAG 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1476020211,2
    C--198124746(+) GTGAAC/TGTTTT 1 -- us2k10--------
    rs67043371,2
    C,F,A,H--198124754(+) tttcaT/Cttatt 1 -- us2k1 tfbs37Minor allele frequency- C:0.29WA NA CSA EA 368

    HapMap Linkage Disequilibrium report for NEK7 (198126093 - 198291550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NEK7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2564043CNV Deletion19546169
    esv269429CNV Insertion20981092
    esv268584CNV Insertion20981092
    esv273344CNV Insertion20981092
    nsv832248CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606848    OMIM disorders: --

    6 diseases for NEK7:    About MalaCards
    polycystic kidney disease    kidney disease    pancreatic cancer    pancreatitis
    breast cancer    prostatitis


    NEK7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEK7
    Human Genome Epidemiology (HuGE) Navigator: NEK7 (2 documents)

    Export disorders for NEK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEK7 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with NEK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PubMed id 11701951)1, 2, 3, 9 Kimura M. and Okano Y. (2001)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    3. The Nek6 and Nek7 protein kinases are required for ro bust mitotic spindle formation and cytokinesis. (PubMed id 19414596)1, 2 O'Regan L. and Fry A.M. (2009)
    4. An autoinhibitory tyrosine motif in the cell-cycle-re gulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)1, 2 Richards M.W....Bayliss R. (2009)
    5. Mitotic regulation by NIMA-related kinases. (PubMed id 17727698)1, 2 O'regan L.... Fry A.M. (2007)
    6. NEK7 is a centrosomal kinase critical for microtubule nucleation. (PubMed id 17586473)1, 2 Kim S....Rhee K. (2007)
    7. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. (PubMed id 17101132)1, 2 Yissachar N....Motro B. (2006)
    8. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. (PubMed id 12840024)1, 2 Belham C....Avruch J. (2003)
    9. Nek7 kinase accelerates microtubule dynamic instabilit y. (PubMed id 23313050)1 Cohen S....Motro B. (2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140609 HGNC: 13386 AceView: NEK7 Ensembl:ENSG00000151414 euGenes: HUgn140609
    ECgene: NEK7 H-InvDB: NEK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEK7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEK7 gene:
    Search GeneIP for patents involving NEK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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