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NEK7 Gene

protein-coding   GIFtS: 64
GCID: GC01P198126

NIMA-Related Kinase 7

(Previous name: NIMA (never in mitosis gene a)-related kinase 7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NIMA-Related Kinase 71 2
NIMA (Never In Mitosis Gene A)-Related Kinase 71 2
Never In Mitosis A-Related Kinase 72 3
NimA-Related Protein Kinase 72 3
EC 2.7.11.13 8
Serine/Threonine-Protein Kinase Nek72

External Ids:    HGNC: 133861   Entrez Gene: 1406092   Ensembl: ENSG000001514147   OMIM: 6068485   UniProtKB: Q8TDX73   

Export aliases for NEK7 gene to outside databases

Previous GC identifers: GC01P195928 GC01P193660 GC01P194592 GC01P195489 GC01P195459 GC01P194933 GC01P196392 GC01P169281


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEK7 Gene:
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans
'never in mitosis A' gene, which controls initiation of mitosis.(supplied by OMIM, Jul 2002)

GeneCards Summary for NEK7 Gene:
NEK7 (NIMA-related kinase 7) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule
nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEK7 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   ISGF-3   oct-B3   oct-B2   POU2F2   GATA-1   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK7 promoter sequence
   Search Chromatin IP Primers for NEK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.3

NEK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P198126:  view genomic region     (about GC identifiers)

Start:
198,126,093 bp from pter      End:
198,291,550 bp from pter
Size:
165,458 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek7  
Size: 302 amino acids; 34551 Da
Cofactor: Magnesium
Subunit: Monomer. Interacts with NEK9
2 PDB 3D structures from and Proteopedia for NEK7:
2WQM (3D)        2WQN (3D)    
Secondary accessions: A6NGT8
Alternative splicing: 2 isoforms:  Q8TDX7-1   Q8TDX7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK7: NX_Q8TDX7

Explore proteomics data for NEK7 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-195 required for its activation1
  • Ubiquitination2 at Lys74, Lys163, Lys189
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NEK7 (Q8TDX7) (see all 7)
     KPANVFIT  KSDIWSLGC  GTPYYMSPE  KIEQCDYPPLP 


    See NEK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_598001.1  
    ENSEMBL proteins: 
     ENSP00000356355   ENSP00000392745   ENSP00000444621   ENSP00000356353   ENSP00000439095  
     ENSP00000375835  
    Reactome Protein details: Q8TDX7

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    antibodies-online proteins for NEK7 (8 products) 

     
    antibodies-online peptides for NEK7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 7
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8TDX7

    ProtoNet protein and cluster: Q8TDX7

    UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
    Domain: Displays an autoinhibited conformation: Tyr-97 side chain points into the active site, interacts with the
    activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9
    Domain: The NTE (N-terminal extension) motif is a structural component of the catalytic domain and thus
    contributes to activity
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with NEK7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK7_HUMAN, Q8TDX7
    Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule
    nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with NEK7           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for NEK7:
     Cell division defect  Decreased substrate adherent c  Decreased telomerase activity  Increased G2M DNA content 
     Increased colony dispersion (i  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nek7):
     cellular  growth/size/body  mortality/aging  vision/eye 

    Find genes that share phenotypes with NEK7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nek7tm1Mot for NEK7

       genOway: Develop your customized and physiologically relevant rodent model for NEK7

    miRNA
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    miRTarBase miRNAs that target NEK7:
    hsa-mir-10b-5p (MIRT047478), hsa-mir-10a-5p (MIRT047638), hsa-mir-340-5p (MIRT019647), hsa-mir-101-3p (MIRT027390)

    Block miRNA regulation of human, mouse, rat NEK7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEK7 (see all 64):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-582-3p hsa-miR-607 hsa-miR-130a* hsa-miR-23c hsa-miR-23b hsa-miR-127-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat NEK7

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK7
    Addgene plasmids for NEK7 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEK7_HUMAN, Q8TDX7: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at
    spindle midzone of the anaphase cells and eventually concentrates at the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with NEK7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEK7 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly0.77
    Activation of NIMA Kinases NEK9, NEK6, NEK70.00
    Nuclear Envelope Breakdown0.77
    3RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with NEK7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NEK7
        Cell Cycle / Checkpoint Control


    2 Reactome Pathways for NEK7
        Nuclear Pore Complex (NPC) Disassembly
    Activation of NIMA Kinases NEK9, NEK6, NEK7


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEK7
    Interactions:

        GeneGlobe Interaction Network for NEK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEK7 (Q8TDX73 ENSP000003563554) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC983, ENSP000003627024I2D: score=2 STRING: ENSP00000362702
    NEK9Q8TD193, ENSP000002386164I2D: score=5 STRING: ENSP00000238616
    TTKENSP000002305104STRING: ENSP00000230510
    BUB1ENSP000003025304STRING: ENSP00000302530
    BUB1BENSP000002875984STRING: ENSP00000287598
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS17727698
    GO:0006468protein phosphorylation IDA12840024
    GO:0007346regulation of mitotic cell cycle TAS17727698
    GO:0051225spindle assembly TAS17727698

    Find genes that share ontologies with NEK7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEK7

    3 HMDB Compounds for NEK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEK7 gene: 
    NM_133494.2  

    Unigene Cluster for NEK7:

    NIMA-related kinase 7
    Hs.24119  [show with all ESTs]
    Unigene Representative Sequence: NM_133494
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367385(uc001gun.4 uc021pgx.1) ENST00000442588 ENST00000538004
    ENST00000367383 ENST00000544035 ENST00000417895 ENST00000391974 ENST00000493790

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NEK7 (see all 64):
    hsa-miR-579 hsa-miR-140-5p hsa-miR-582-3p hsa-miR-607 hsa-miR-130a* hsa-miR-23c hsa-miR-23b hsa-miR-127-5p
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      QuantiFast Probe-based Assays in human, mouse, rat NEK7

    Additional mRNA sequence: 

    AB062450.1 AK313411.1 AL080111.1 

    7 DOTS entries:

    DT.213680  DT.100022128  DT.100776055  DT.99993701  DT.121364292  DT.95272718  DT.95272719 

    Selected AceView cDNA sequences (see all 204):

    CB159764 AA295264 AI361369 BU681351 BE887322 CA390798 BM783345 BQ959234 
    BM543219 BQ022852 BU752890 AI696961 AW262762 AI476071 AI954282 BU752959 
    BQ024065 AI809185 BU684109 CA438605 BQ023934 AA972531 AW771141 BF057667 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCTTTAC
    NEK7 Expression
    About this image


    NEK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Diencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    NEK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEK7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24119

    UniProtKB/Swiss-Prot: NEK7_HUMAN, Q8TDX7
    Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower
    expression in ovary, prostate and kidney. No expression seen in small intestine

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEK7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek71 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 91.28(n)1
    97.68(a)1
      1 (60.82 cM)5
    591251  NM_021605.31  NP_067618.11 
     1384847145 
    chicken
    (Gallus gallus)
    Aves NEK71 NIMA (never in mitosis gene a)-related kinase 7 85.98(n)
    98.01(a)
      424350  NM_001031264.1  NP_001026435.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEK76
    NIMA-related kinase 7
    96(a)
    1 ↔ 1
    GL343211.1(213841-299458)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nek71 NIMA-related kinase 7 80.91(n)
    95.03(a)
      780029  NM_001079106.1  NP_001072574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nek71 NIMA (never in mitosis gene a)-related kinase 7 76.43(n)
    88.89(a)
      445223  NM_001003617.1  NP_001003617.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nekl-31 nekl-3 65.79(n)
    75.28(a)
      181398  NM_077679.5  NP_510080.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN36
    Nonessential serine/threonine protein kinase; poss...
    21(a)
    1 → many
    I(170396-171703) YAR018C


    ENSEMBL Gene Tree for NEK7 (if available)
    TreeFam Gene Tree for NEK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEK7 gene
    NEK42  NEK62  NEK12  NEK112  NEK32  NEK52  NEK22  NEK82  
    NEK102  NEK92  
    Selected SIMAP similar genes for NEK7 using alignment to 4 protein entries:     NEK7_HUMAN (see all proteins) (see all similar genes):
    NEK6    NEK1    NEK8    NEK11    NEK5    NEK2
    NEK4    NEK10    NEK3    DKFZp434B079    NEK9    STK25
    YSK4    MAP2K3    MAP3K19    MAP3K2    MAP3K4    OXSR1

    Find genes that share paralogs with NEK7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEK7 (see all 3076)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409254
    An ovarian serous carcinoma sample4--see VAR_0409252 I M mis40--------
    rs2016760701,2
    Cuntested1198262082(+) GGTACA/GCCTTA 2 T syn10--------
    rs57799061,2
    C--169301164(+) ATATA-/TAATGGG 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs1477934711,2
    --198124183(+) GATTTA/GGTCAC 1 -- us2k10--------
    rs1411921741,2
    --198124361(+) AAGCCC/GACTTC 1 -- us2k10--------
    rs1893965641,2
    --198124431(+) CAAATA/GGCTAA 1 -- us2k10--------
    rs125661851,2
    C,F,H--198124475(+) agagaG/Agcatt 1 -- us2k1 tfbs35Minor allele frequency- A:0.01NS EA NA 416
    rs727494741,2
    C,F--198124732(+) CTCCTT/CTTGAG 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1476020211,2
    C--198124746(+) GTGAAC/TGTTTT 1 -- us2k10--------
    rs67043371,2
    C,F,A,H--198124754(+) tttcaT/Cttatt 1 -- us2k1 tfbs37Minor allele frequency- C:0.29WA NA CSA EA 368

    HapMap Linkage Disequilibrium report for NEK7 (198126093 - 198291550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NEK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2564043CNV Deletion19546169
    esv269429CNV Insertion20981092
    esv268584CNV Insertion20981092
    esv273344CNV Insertion20981092
    nsv832248CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEK7
    DNA2.0 Custom Variant and Variant Library Synthesis for NEK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606848    OMIM disorders: --


    Find genes that share disorders with NEK7           About GenesLikeMe

    Genetic Association Database (GAD): NEK7
    Human Genome Epidemiology (HuGE) Navigator: NEK7 (2 documents)

    Export disorders for NEK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEK7 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NEK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PubMed id 11701951)1, 2, 3, 9 Kimura M. and Okano Y. (Cytogenet. Cell Genet. 2001)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    3. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. (PubMed id 19414596)1, 2 O'Regan L. and Fry A.M. (Mol. Cell. Biol. 2009)
    4. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)1, 2 Richards M.W.... Bayliss R. (Mol. Cell 2009)
    5. Mitotic regulation by NIMA-related kinases. (PubMed id 17727698)1, 2 O'regan L.... Fry A.M. (Cell Div. 2007)
    6. NEK7 is a centrosomal kinase critical for microtubule nucleation. (PubMed id 17586473)1, 2 Kim S.... Rhee K. (Biochem. Biophys. Res. Commun. 2007)
    7. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. (PubMed id 17101132)1, 2 Yissachar N.... Motro B. (FEBS Lett. 2006)
    8. A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. (PubMed id 12840024)1, 2 Belham C....Avruch J. (J. Biol. Chem. 2003)
    9. A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms. (PubMed id 23821772)1 Dodson C.A....Bayliss R. (Sci Signal 2013)
    10. Nek7 kinase accelerates microtubule dynamic instability. (PubMed id 23313050)1 Cohen S....Motro B. (Biochim. Biophys. Acta 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140609 HGNC: 13386 AceView: NEK7 Ensembl:ENSG00000151414 euGenes: HUgn140609
    ECgene: NEK7 H-InvDB: NEK7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEK7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEK7 gene:
    Search GeneIP for patents involving NEK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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