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Aliases for NEK6 Gene

Aliases for NEK6 Gene

  • NIMA-Related Kinase 6 2 3
  • NIMA (Never In Mitosis Gene A)-Related Kinase 6 2 3
  • Putative Serine-Threonine Protein Kinase 2 3
  • Never In Mitosis A-Related Kinase 6 3 4
  • NimA-Related Protein Kinase 6 3 4
  • Protein Kinase SID6-1512 3 4
  • EC 2.7.11.1 4 64
  • Serine/Threonine-Protein Kinase Nek6 3
  • SID6-1512 3

External Ids for NEK6 Gene

Summaries for NEK6 Gene

Entrez Gene Summary for NEK6 Gene

  • The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NEK6 Gene

NEK6 (NIMA-Related Kinase 6) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and signal transducer activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK6 Gene

  • Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.

Gene Wiki entry for NEK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK6 Gene

Genomics for NEK6 Gene

Genomic Location for NEK6 Gene

Start:
124,257,606 bp from pter
End:
124,353,307 bp from pter
Size:
95,702 bases
Orientation:
Plus strand

Genomic View for NEK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK6 Gene

Regulatory Elements for NEK6 Gene

Proteins for NEK6 Gene

  • Protein details for NEK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC98-NEK6_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek6
    Protein Accession:
    Q9HC98
    Secondary Accessions:
    • B7Z2D9
    • Q5TBG3
    • Q5TBG9
    • Q6FG86
    • Q6IAR3
    • Q96E83
    • Q9ULX2

    Protein attributes for NEK6 Gene

    Size:
    313 amino acids
    Molecular mass:
    35714 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with STAT3 and RPS6KB1 (By similarity). Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus). Interacts with APBB1 (via WW domain). Interacts with ANKRA2, ATF4, ARHGAP33, CDC42, CIR1, PRAM1, PTN, PRDX3, PIN1, RAD26L, RBBP6, RPS7 and TRIP4.
    SequenceCaution:
    • Sequence=AAG13417.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH00101.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH04174.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH04209.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA85045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK6 Gene

Proteomics data for NEK6 Gene at MOPED

Post-translational modifications for NEK6 Gene

  • Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys174

Domains for NEK6 Gene

UniProtKB/Swiss-Prot:

NEK6_HUMAN
Domain:
  • Displays an autoinhibited conformation: Tyr-108 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix. The autoinhibitory conformation is released upon binding with NEK9.:
    • Q9HC98
  • Contains 1 protein kinase domain.:
    • Q9HC98
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.:
    • Q9HC98
genes like me logo Genes that share domains with NEK6: view

Function for NEK6 Gene

Molecular function for NEK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-108.
UniProtKB/Swiss-Prot Function: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.
UniProtKB/Swiss-Prot Induction: Up-regulated during the M phase of cell cycle progression. Down-regulated in both replicative and premature senescence of cancer cells.

Enzyme Numbers (IUBMB) for NEK6 Gene

Gene Ontology (GO) - Molecular Function for NEK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14563848
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14563848
GO:0004713 protein tyrosine kinase activity --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with NEK6: view
genes like me logo Genes that share phenotypes with NEK6: view

miRNA for NEK6 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NEK6 Gene

Localization for NEK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK6 Gene

Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK6 Gene COMPARTMENTS Subcellular localization image for NEK6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NEK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IDA 12054534
GO:0005737 cytoplasm IDA 12054534
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NEK6: view

Pathways for NEK6 Gene

genes like me logo Genes that share pathways with NEK6: view

Pathways by source for NEK6 Gene

Gene Ontology (GO) - Biological Process for NEK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000910 cytokinesis TAS 21200151
GO:0006468 protein phosphorylation IDA 12840024
GO:0006915 apoptotic process IEA --
GO:0007059 chromosome segregation IDA 14563848
genes like me logo Genes that share ontologies with NEK6: view

Compounds for NEK6 Gene

(3) HMDB Compounds for NEK6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with NEK6: view

Transcripts for NEK6 Gene

Unigene Clusters for NEK6 Gene

NIMA-related kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for NEK6 Gene

GeneLoc Exon Structure for
NEK6
ECgene alternative splicing isoforms for
NEK6

Expression for NEK6 Gene

mRNA expression in normal human tissues for NEK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEK6 Gene

This gene is overexpressed in Liver (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK6 Gene

SOURCE GeneReport for Unigene cluster for NEK6 Gene Hs.197071

mRNA Expression by UniProt/SwissProt for NEK6 Gene

Q9HC98-NEK6_HUMAN
Tissue specificity: Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers.
genes like me logo Genes that share expressions with NEK6: view

Orthologs for NEK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK6 36
  • 99.01 (n)
  • 99.11 (a)
NEK6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK6 36
  • 90.63 (n)
  • 96.17 (a)
NEK6 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK6 36
  • 89.53 (n)
  • 96.04 (a)
NEK6 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek6 36
  • 88.71 (n)
  • 95.21 (a)
Nek6 16
Nek6 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK6 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK6 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek6 36
  • 89.24 (n)
  • 96.17 (a)
chicken
(Gallus gallus)
Aves NEK6 36
  • 75.72 (n)
  • 88.82 (a)
NEK6 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK6 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nek6-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nek6 36
  • 77.44 (n)
  • 88.89 (a)
Str.12097 36
zebrafish
(Danio rerio)
Actinopterygii nek6 36
  • 76.31 (n)
  • 83.52 (a)
nek6 37
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-3 37
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 64 (a)
OneToMany
Species with no ortholog for NEK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK6 Gene

ENSEMBL:
Gene Tree for NEK6 (if available)
TreeFam:
Gene Tree for NEK6 (if available)

Paralogs for NEK6 Gene

Paralogs for NEK6 Gene

genes like me logo Genes that share paralogs with NEK6: view

Variants for NEK6 Gene

Sequence variations from dbSNP and Humsavar for NEK6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2416 -- 124,351,381(-) GATAC(C/T)AAGAA utr-variant-3-prime
rs748659 -- 124,333,424(-) TGACC(C/T)AGGGG intron-variant
rs748660 -- 124,333,370(-) TCACT(C/G)GGGGG intron-variant
rs748661 -- 124,333,295(-) TGTGA(C/T)GGCAA intron-variant
rs748741 -- 124,327,496(-) CTGCA(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK6 Gene

Variant ID Type Subtype PubMed ID
nsv831719 CNV Gain 17160897
nsv831720 CNV Loss 17160897
nsv6711 CNV Loss 18451855
nsv471322 CNV Loss 18288195
nsv519767 CNV Loss 19592680
nsv825074 CNV Gain 20364138
nsv893833 CNV Gain 21882294
esv2677076 CNV Deletion 23128226
esv2739034 CNV Deletion 23290073
esv2739035 CNV Deletion 23290073

Relevant External Links for NEK6 Gene

HapMap Linkage Disequilibrium report
NEK6

Disorders for NEK6 Gene

(1) University of Copenhagen DISEASES for NEK6 Gene

Relevant External Links for NEK6

Genetic Association Database (GAD)
NEK6
Human Genome Epidemiology (HuGE) Navigator
NEK6
genes like me logo Genes that share disorders with NEK6: view

No data available for UniProtKB/Swiss-Prot for NEK6 Gene

Publications for NEK6 Gene

  1. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. (PMID: 14563848) Yin M.J. … Jallal B. (J. Biol. Chem. 2003) 3 4 23
  2. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PMID: 16476580) Chen J. … Yu L. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. (PMID: 17512906) Lee E.J. … Kang S.S. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  4. Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping. (PMID: 10702691) Li M.Z. … Zhao S.Y. (Cytogenet. Cell Genet. 1999) 2 3
  5. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PMID: 11701951) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 2001) 3 23

Products for NEK6 Gene

  • Addgene plasmids for NEK6

Sources for NEK6 Gene

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