NEK6 Gene

Aliases
for NEK6 gene

Previous GC identifers: GC09P118134 GC09P118666 GC09P120473 GC09P122395 GC09P122396 GC09P124099 GC09P126059 GC09P096633

Summaries
for NEK6 gene

Genomic Views
for NEK6 gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmids (see all 2): NEK6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK6

NEK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P127019:  view genomic region     (about GC identifiers)

Proteins
for NEK6 gene

Explore the universe of human proteins at neXtProt for NEK6: NX_Q9HC98

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant NEK6 Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for NEK6
	OriGene Purified Proteins (see all 2): NEK6 OriGene Protein Over-expression Lysate (see all 6): NEK6 OriGene Custom Protein Services for NEK6
	GenScript Custom Purified and Recombinant Proteins Services for NEK6
	Novus Biologicals NEK6 Proteins Novus Biologicals NEK6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NEK6

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 5): NEK6 OriGene Custom Antibody Services for NEK6
	GenScript Custom Superior Antibodies Services for NEK6
	Novus Biologicals NEK6 Antibodies
	Abcam antibodies for NEK6
	Uscn Antibodies for NEK6
	ThermoFisher Antibodies for NEK6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEK6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEK6

Protein Domains /
Families
for NEK6 gene

ProtoNet protein and cluster: Q9HC98

Function
for NEK6 gene

Enzyme Number (IUBMB): EC 2.7.11.1^{1 2}

miRNA Products:		miRTarBase miRNAs that target NEK6: hsa-mir-124 (MIRT002611)
		OriGene 3'-UTR Clone (see all 7): NEK6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEK6
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NEK6 (see all 30):
		hsa-miR-3685 hsa-miR-323-3p hsa-miR-188-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-200a hsa-miR-500a hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: NEK6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEK6 (see all 7) OriGene shRNA RFP: NEK6 OriGene siRNA: NEK6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NEK6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK6 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK6 (see all 7) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): NEK6 (NM_001145001)
		Sino Biological Human cDNA Clone for NEK6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEK6
		Search LifeMap BioReagents cell lines for NEK6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK6

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

(inferred from 2 alleles) (MGI details for Nek6)

Pathways & Interactions
for NEK6 gene

	Super-pathway	contained gene-specific pathways
1	Clearance of Nuclear Envelope Membranes from Chromatin	Nuclear Envelope Breakdown 0.56 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.00 Mitotic Prophase 0.26
2	M Phase	M Phase 1.00 Mitotic M-M/G1 phases 0.88
3	Cell Cycle	Cell Cycle 1.00 Cell Cycle, Mitotic 0.84

5/7        Reactome Pathways for NEK6

	Mitotic Prophase
	Cell Cycle
	M Phase
	Mitotic M-M/G1 phases
	Nuclear Envelope Breakdown

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

Drugs & Compounds
for NEK6 gene

Transcripts
for NEK6 gene

Expression
for NEK6 gene

NEK6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACTGATGG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEK6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEK6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK6

Orthologs
for NEK6 gene

Paralogs
for NEK6 gene

Paralogs for NEK6 gene

NEK4²  NEK1²  NEK11²  NEK3²  NEK7²  NEK5²  NEK2²  NEK8²  

NEK10²  NEK9²  

18/108 SIMAP similar genes for NEK6 using alignment to 8 protein entries:     NEK6_HUMAN (see all proteins) (see all similar genes):

NEK7    MST094    NEK8    NEK1    DKFZp564L2416    NEK2

NEK5    DKFZp434B079    NEK3    NEK9    ABL1    CDKL3

MAP2K2    NEK10    NEK4    MYLK    NEK11    MAP3K6

NEK6 for paralogs           About GeneDecksing

Genomic Variants
for NEK6 gene

10/1665 NCBI SNPs in NEK6 are shown (see all 1665)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs123401781,2		--	96631595(+)	gtagaC/Gacagg	1	--	us2k1		0	--	--	--	--
rs1385930361,2		--	127018037(+)	CTTCCA/GAGTTA	1	--	us2k1		0	--	--	--	--
rs713729551,2	C	--	127018060(+)	TTTTTT/-GGAGA	1	--	us2k1		1		NA	2
rs1492849571,2		--	127018128(+)	ATCTCA/GGCTCA	1	--	us2k1		0	--	--	--	--
rs1381952731,2		--	127018347(+)	GCCACC/GGCGCC	3	--	us2k1		0	--	--	--	--
rs109862931,2	C,F,	--	127018350(+)	ACCGCG/ACCCGG	3	--	us2k1		4		NA WA CSA	8
rs1472388551,2		--	127018353(+)	GCGCCC/TGGCCC	3	--	us2k1		0	--	--	--	--
rs1812306951,2		--	127018426(+)	TGACTA/GAAGCC	3	--	us2k1		0	--	--	--	--
rs1406873271,2		--	127018938(+)	CTGCCA/GTGCAC	4	--	us2k1		0	--	--	--	--
rs109862941,2	C,F,	--	127019113(+)	TGCAGG/ACAGGC	4	--	us2k1		2		NA EA	240

HapMap Linkage Disequilibrium report for NEK6 (127019885 - 127115586 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NEK6
     4 CNVs: 30333 30334 52708 30332

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEK6

DNA2.0 Custom Variant and Variant Library Synthesis for NEK6

Disorders / Diseases
for NEK6 gene

Publications
for NEK6 gene

PubMed articles for NEK6 gene, integrated from 9 sources (see all 44): (articles sorted by number of sources associating them with NEK6)

Utopia: connect your pdf to the dynamic world of online information

1. Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. (PubMed id 17512906)^{1, 2, 9} Lee E.J....Kang S.S. (2007)
2. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. (PubMed id 14563848)^{1, 2, 9} Yin M.J.... Jallal B. (2003)
3. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PubMed id 16476580)^{1, 2, 9} Chen J....Yu L. (2006)
4. Nek6 overexpression antagonizes p53-induced senescenc e in human cancer cells. (PubMed id 21099361)^{1, 2} Jee H.J....Yun J. (2010)
5. Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target. (PubMed id 20407017)^{1, 2} Nassirpour R....Yin M.J. (2010)
6. Characterization of hNek6 interactome reveals an impo rtant role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)^{1, 2} Vaz Meirelles G....Kobarg J. (2010)
7. The Nek6 and Nek7 protein kinases are required for ro bust mitotic spindle formation and cytokinesis. (PubMed id 19414596)^{1, 2} O'Regan L. and Fry A.M. (2009)
8. Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. (PubMed id 18728393)^{1, 2} Lee M.Y....Yun J. (2008)
9. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)^{1, 2} Rapley J....Roig J. (2008)
10. Caught Nek-ing: cilia and centrioles. (PubMed id 16280549)^{1, 2} Quarmby L.M. and Mahjoub M.R. (2005)

External Searches for NEK6 gene

Genome Databases showing NEK6 gene

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Specialized Databases showing NEK6 gene

Products
for NEK6 gene