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Aliases for NEK5 Gene

Aliases for NEK5 Gene

  • NIMA-Related Kinase 5 2 3
  • EC 2.7.11.1 4 63
  • NIMA (Never In Mitosis Gene A)-Related Kinase 5 2
  • Never In Mitosis A-Related Kinase 5 4
  • NimA-Related Protein Kinase 5 4
  • EC 2.7.11 63

External Ids for NEK5 Gene

Summaries for NEK5 Gene

GeneCards Summary for NEK5 Gene

NEK5 (NIMA-Related Kinase 5) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK5 Gene

Genomics for NEK5 Gene

Genomic Location for NEK5 Gene

Start:
52,033,611 bp from pter
End:
52,129,078 bp from pter
Size:
95,468 bases
Orientation:
Minus strand

Genomic View for NEK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK5 Gene

Regulatory Elements for NEK5 Gene

Proteins for NEK5 Gene

  • Protein details for NEK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3R8-NEK5_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek5
    Protein Accession:
    Q6P3R8
    Secondary Accessions:
    • Q5TAP5

    Protein attributes for NEK5 Gene

    Size:
    708 amino acids
    Molecular mass:
    81445 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NEK5 Gene

Proteomics data for NEK5 Gene at MOPED

Selected DME Specific Peptides for NEK5 Gene

Post-translational modifications for NEK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for NEK5 Gene

Suggested Antigen Peptide Sequences for NEK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3R8

UniProtKB/Swiss-Prot:

NEK5_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q6P3R8
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.:
    • Q6P3R8
genes like me logo Genes that share domains with NEK5: view

Function for NEK5 Gene

Molecular function for NEK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for NEK5 Gene

Gene Ontology (GO) - Molecular Function for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with NEK5: view

Phenotypes for NEK5 Gene

GenomeRNAi human phenotypes for NEK5:
genes like me logo Genes that share phenotypes with NEK5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NEK5 Gene

Localization for NEK5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK5 Gene COMPARTMENTS Subcellular localization image for NEK5 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with NEK5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NEK5 Gene

Pathways for NEK5 Gene

SuperPathways for NEK5 Gene

No Data Available

Interacting Proteins for NEK5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347767%0d%0a9606.ENSP00000380256%0d%0a9606.ENSP00000274026%0d%0a9606.ENSP00000255465%0d%0a
Selected Interacting proteins: ENSP00000347767 for NEK5 Gene via STRING

Gene Ontology (GO) - Biological Process for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA --
GO:0051155 positive regulation of striated muscle cell differentiation IEA --
GO:2001056 positive regulation of cysteine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view

No data available for Pathways by source for NEK5 Gene

Compounds for NEK5 Gene

(3) HMDB Compounds for NEK5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with NEK5: view

Transcripts for NEK5 Gene

mRNA/cDNA for NEK5 Gene

(15) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEK5 Gene

NIMA-related kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK5 Gene

No ASD Table

Relevant External Links for NEK5 Gene

GeneLoc Exon Structure for
NEK5
ECgene alternative splicing isoforms for
NEK5

Expression for NEK5 Gene

mRNA expression in normal human tissues for NEK5 Gene

mRNA differential expression in normal tissues according to GTEx for NEK5 Gene

This gene is overexpressed in Testis (15.4) and Fallopian Tube (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEK5 Gene

SOURCE GeneReport for Unigene cluster for NEK5 Gene Hs.672144

genes like me logo Genes that share expressions with NEK5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NEK5 Gene

Orthologs for NEK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK5 35
  • 99.53 (n)
  • 99.29 (a)
NEK5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK5 35
  • 85.6 (n)
  • 78.32 (a)
NEK5 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek5 35
  • 79.65 (n)
  • 72.69 (a)
Nek5 16
Nek5 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK5 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK5 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek5 35
  • 79.79 (n)
  • 73.56 (a)
chicken
(Gallus gallus)
Aves NEK5 35
  • 64.38 (n)
  • 55.73 (a)
NEK5 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK5 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15191 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nek5 35
  • 61.78 (n)
  • 57.1 (a)
zebrafish
(Danio rerio)
Actinopterygii NEK5 36
  • 59 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for NEK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEK5 Gene

ENSEMBL:
Gene Tree for NEK5 (if available)
TreeFam:
Gene Tree for NEK5 (if available)

Paralogs for NEK5 Gene

Paralogs for NEK5 Gene

Selected SIMAP similar genes for NEK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEK5: view

Variants for NEK5 Gene

Sequence variations from dbSNP and Humsavar for NEK5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs719349 -- 52,068,338(-) CTATA(C/T)ATTGG intron-variant
rs755363 -- 52,103,033(-) TTAAA(C/T)GATGT intron-variant
rs1000892 -- 52,120,566(+) AAATG(A/G)CTGAT intron-variant
rs1004576 -- 52,121,845(-) CAATA(A/G)CATTT intron-variant
rs1006432 -- 52,115,777(-) AGTGT(C/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK5 Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294
esv2747423 CNV Deletion 23290073
esv2747424 CNV Deletion 23290073
esv2549303 CNV Deletion 19546169

Relevant External Links for NEK5 Gene

HapMap Linkage Disequilibrium report
NEK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK5 Gene

Disorders for NEK5 Gene

No disorders were found for NEK5 Gene.

No data available for UniProtKB/Swiss-Prot for NEK5 Gene

Publications for NEK5 Gene

  1. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (PMID: 9552363) Lu K.P. … Hunter T. (Prog Cell Cycle Res 1995) 2 3
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NEK5 Gene

Sources for NEK5 Gene

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