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Aliases for NEK5 Gene

Aliases for NEK5 Gene

  • NIMA Related Kinase 5 2 3
  • EC 2.7.11.1 4 63
  • NIMA (Never In Mitosis Gene A)-Related Kinase 5 2
  • Never In Mitosis A-Related Kinase 5 4
  • NimA-Related Protein Kinase 5 4
  • NIMA-Related Kinase 5 5
  • EC 2.7.11 63

External Ids for NEK5 Gene

Previous GeneCards Identifiers for NEK5 Gene

  • GC13U990078
  • GC13M051537
  • GC13M052610
  • GC13M033427

Summaries for NEK5 Gene

GeneCards Summary for NEK5 Gene

NEK5 (NIMA Related Kinase 5) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK5 Gene

Genomics for NEK5 Gene

Regulatory Elements for NEK5 Gene

Promoters for NEK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK5 Gene

Chromosome:
13
Start:
52,033,611 bp from pter
End:
52,130,366 bp from pter
Size:
96,756 bases
Orientation:
Minus strand

Genomic View for NEK5 Gene

Genes around NEK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK5 Gene

Proteins for NEK5 Gene

  • Protein details for NEK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3R8-NEK5_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek5
    Protein Accession:
    Q6P3R8
    Secondary Accessions:
    • Q5TAP5

    Protein attributes for NEK5 Gene

    Size:
    708 amino acids
    Molecular mass:
    81445 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NEK5 Gene

Proteomics data for NEK5 Gene at MOPED

Selected DME Specific Peptides for NEK5 Gene

Post-translational modifications for NEK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NEK5 Gene

Gene Families for NEK5 Gene

Suggested Antigen Peptide Sequences for NEK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3R8

UniProtKB/Swiss-Prot:

NEK5_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK5: view

Function for NEK5 Gene

Molecular function for NEK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for NEK5 Gene

Gene Ontology (GO) - Molecular Function for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK5: view
genes like me logo Genes that share phenotypes with NEK5: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK5 Gene

Localization for NEK5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK5 Gene COMPARTMENTS Subcellular localization image for NEK5 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NEK5 Gene

Pathways & Interactions for NEK5 Gene

SuperPathways for NEK5 Gene

No Data Available

Interacting Proteins for NEK5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347767%0d%0a9606.ENSP00000274026%0d%0a9606.ENSP00000380256%0d%0a9606.ENSP00000255465%0d%0a
Selected Interacting proteins: ENSP00000347767 for NEK5 Gene via STRING

Gene Ontology (GO) - Biological Process for NEK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051155 positive regulation of striated muscle cell differentiation IEA --
GO:2001056 positive regulation of cysteine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with NEK5: view

No data available for Pathways by source and SIGNOR curated interactions for NEK5 Gene

Drugs & Compounds for NEK5 Gene

(2) Drugs for NEK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for NEK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK5: view

Transcripts for NEK5 Gene

mRNA/cDNA for NEK5 Gene

(15) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEK5 Gene

NIMA-related kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK5 Gene

No ASD Table

Relevant External Links for NEK5 Gene

GeneLoc Exon Structure for
NEK5
ECgene alternative splicing isoforms for
NEK5

Expression for NEK5 Gene

mRNA expression in normal human tissues for NEK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEK5 Gene

This gene is overexpressed in Testis (x15.4) and Fallopian Tube (x4.1).

Protein differential expression in normal tissues from HIPED for NEK5 Gene

This gene is overexpressed in Serum (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK5 Gene



SOURCE GeneReport for Unigene cluster for NEK5 Gene Hs.672144

genes like me logo Genes that share expression patterns with NEK5: view

Protein tissue co-expression partners for NEK5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NEK5 Gene

Orthologs for NEK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEK5 35
  • 85.6 (n)
  • 78.32 (a)
NEK5 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek5 35
  • 79.65 (n)
  • 72.69 (a)
Nek5 16
Nek5 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEK5 35
  • 99.53 (n)
  • 99.29 (a)
NEK5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek5 35
  • 79.79 (n)
  • 73.56 (a)
oppossum
(Monodelphis domestica)
Mammalia NEK5 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK5 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK5 35
  • 64.38 (n)
  • 55.73 (a)
NEK5 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK5 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek5 35
  • 61.78 (n)
  • 57.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15191 35
zebrafish
(Danio rerio)
Actinopterygii NEK5 36
  • 59 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for NEK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEK5 Gene

ENSEMBL:
Gene Tree for NEK5 (if available)
TreeFam:
Gene Tree for NEK5 (if available)

Paralogs for NEK5 Gene

Paralogs for NEK5 Gene

(22) SIMAP similar genes for NEK5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NEK5: view

Variants for NEK5 Gene

Sequence variations from dbSNP and Humsavar for NEK5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_040922 -
VAR_040923 -
rs34756139 - 52,102,139(+) CCTTT(G/T)CAAAA nc-transcript-variant, reference, missense
rs755363 -- 52,103,033(-) TTAAA(C/T)GATGT intron-variant
rs1000892 -- 52,120,566(+) AAATG(A/G)CTGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEK5 Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294
esv2747423 CNV Deletion 23290073
esv2747424 CNV Deletion 23290073
esv2549303 CNV Deletion 19546169

Variation tolerance for NEK5 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK5 Gene

HapMap Linkage Disequilibrium report
NEK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK5 Gene

Disorders for NEK5 Gene

Relevant External Links for NEK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK5

No disorders were found for NEK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK5 Gene

Publications for NEK5 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (PMID: 9552363) Lu K.P. … Hunter T. (Prog Cell Cycle Res 1995) 2 3
  3. Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis. (PMID: 25963817) Prosser S.L. … Fry A.M. (J. Cell Biol. 2015) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NEK5 Gene

Sources for NEK5 Gene

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