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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NEK5 Gene

protein-coding GIFtS: 43
GCID: GC13M052610

NIMA-related kinase 5

(Previous name: NIMA (never in mitosis gene a)-related kinase 5 )

Explore 1 disease affiliated with
NEK5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NIMA-Related Kinase 5¹ ²		EC 2.7.11.1³ ⁸
NIMA (Never In Mitosis Gene A)-Related Kinase 5¹ ²		Serine/Threonine-Protein Kinase Nek5²
Never In Mitosis A-Related Kinase 5² ³		EC 2.7.11⁸
NimA-Related Protein Kinase 5² ³

External Ids:	HGNC: 7748¹	Entrez Gene: 341676²	Ensembl: ENSG00000197168⁷	UniProtKB: Q6P3R8³

Export aliases for NEK5 gene to outside databases

Previous GC identifers: GC13U990078 GC13M051537 GC13M033427

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEK5 gene promoter:
FOXF2 Tal-1 Pbx1a Nkx2-2 MyoD E47 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEK5 promoter sequence

Search SABiosciences Chromatin IP Primers for NEK5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.2

NEK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK5 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M052610: view genomic region (about GC identifiers)

Start:	52,611,093 bp from pter	End:	52,703,214 bp from pter
Size:	92,122 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEK5_HUMAN, Q6P3R8 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase Nek5

Size: 708 amino acids; 81445 Da

Cofactor: Magnesium (By similarity)

Secondary accessions: Q5TAP5

Explore the universe of human proteins at neXtProt for NEK5: NX_Q6P3R8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P3R8

2 DME Specific Peptides for NEK5 (Q6P3R8)

SPRDRPSI

GTPYYLSPE

NEK5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_954983.1

ENSEMBL proteins:

ENSP00000431956 ENSP00000347767

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEK5 for domains About GeneDecksing

5 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q6P3R8

ProtoNet protein and cluster: Q6P3R8

UniProtKB/Swiss-Prot: NEK5_HUMAN, Q6P3R8

Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NEK5_HUMAN, Q6P3R8

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--

NEK5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NEK5:

Decreased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NEK5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for NEK5

3 HMDB Compounds for NEK5 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about NEK5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for NEK5 gene:

NM_199289.1

Unigene Cluster for NEK5:

NIMA-related kinase 5

Hs.672144 [show with all ESTs]

Unigene Representative Sequence: BC063885

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000529080 ENST00000465811 ENST00000355568(uc001vge.3)

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Additional cDNA sequence: BC063885.1

3 DOTS entries:

DT.100712727 DT.100699991 DT.75116488

13 AceView cDNA sequences:

CR598570 BC063885 AW173561 BX417448 BX350584 BX342707 AK126330 AW002801

CD700193 CD243608 BX328262 CD705373 BX342706

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NEK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NEK5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NEK5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.672144

SABiosciences Custom PCR Arrays for NEK5

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NEK5 gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NEK5¹	NIMA (never in mitosis gene a)-related kinase 5	62.81(n) 54.78(a)		418881 XM_417075.2 XP_417075.2
lizard (Anolis carolinensis)	Reptilia	NEK5⁶	--	45(a)	1 ↔ 1	1(132767953-132790347)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15191²	Xenopus laevis transcribed sequence with weak similarity more	76.18(n)		BJ061491.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01073359.1⁶ si:dkey-192d15.1⁶ (see all 10)	si:dkey-192d15.1 (see all 10)	60(a) 45(a) (see all 10)	possible ortholog possible ortholog (see all 10)	9(58050126-58052178) 7(3732481-3744275)

ENSEMBL Gene Tree for NEK5 (if available)
TreeFam Gene Tree for NEK5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NEK5 gene

NEK4² NEK6² NEK1² NEK11² NEK3² NEK7² NEK8² NEK2²

NEK10² NEK9²

18/66 SIMAP similar genes for NEK5 using alignment to 2 protein entries: NEK5_HUMAN (see all proteins) (see all similar genes):

DKFZp564L2416 NEK3 NEK8 DKFZp434B079 NEK4 NEK9

SGK3 STK32A RPS6KA3 MARK4 RPS6KA2 BRAF

CAMK1 NEK6 PHKG1 CDK7 MAP3K11 NEK7

NEK5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4444230^1,2		--	52638622(+)	`ccgtcC/Tgggag`	1	--	int¹		0	--	--	--	--
rs190015870^1,2		--	52638650(+)	`CCCCCC/TGCCTG`	1	--	int¹		0	--	--	--	--
rs112693315^1,2	C,	--	52638742(+)	`ACCACC/TCTGTC`	1	--	int¹		0	--	--	--	--
rs145604310^1,2		--	52639155(+)	`AACCAC/GAGACC`	1	--	ut3¹		0	--	--	--	--
rs140423467^1,2		--	52639178(+)	`TTTATC/TTGCTG`	1	--	ut3¹		0	--	--	--	--
rs185720150^1,2		--	52639230(+)	`CTCTGC/TGAGAA`	1	--	ut3¹		0	--	--	--	--
rs145437450^1,2		--	52639231(+)	`TCTGCA/GAGAAA`	1	--	ut3¹		0	--	--	--	--
rs192317587^1,2		--	52639261(+)	`AAAAAC/TAAAAA`	1	--	ut3¹		0	--	--	--	--
rs184096862^1,2		--	52639288(+)	`GACCCC/TATGAA`	1	--	ut3¹		0	--	--	--	--
rs71437831^1,2	C,F,	--	52639462(+)	`CTCTTT/CAGGCA`	1	--	ut3¹		3		NA	124

HapMap Linkage Disequilibrium report for NEK5 (52611093 - 52703214 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NEK5
1 CNV: 101742

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEK5 for disorders About GeneDecksing

1 disease for NEK5: About MalaCards

malaria

Export disorders for NEK5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NEK5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NEK5)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells. (PubMed id 9552363)^{1, 3} Lu K.P. and Hunter T. (1995)
Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 341676	HGNC: 7748	AceView: MGC75495	Ensembl:ENSG00000197168	euGenes: HUgn341676
ECgene: NEK5	H-InvDB: NEK5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NEK5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NEK5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NEK5 gene:
Search GeneIP for patents involving NEK5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NEK5 gene at Home site.

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NEK5 Gene

NIMA-related kinase 5

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NEK5 Gene

NIMA-related kinase 5

Aliasesfor NEK5 gene

Summariesfor NEK5 gene

Genomic Viewsfor NEK5 gene

Proteinsfor NEK5 gene

Protein Domains /Familiesfor NEK5 gene

Functionfor NEK5 gene

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for NEK5 gene

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for NEK5 gene

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for NEK5 gene

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for NEK5 gene

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