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Aliases for NEK4 Gene

Aliases for NEK4 Gene

  • NIMA Related Kinase 4 2 3
  • NIMA (Never In Mitosis Gene A)-Related Kinase 4 2 3
  • Serine/Threonine-Protein Kinase NRK2 3 4
  • Never In Mitosis A-Related Kinase 4 3 4
  • Serine/Threonine Protein Kinase-2 2 3
  • Serine/Threonine-Protein Kinase 2 3 4
  • NimA-Related Protein Kinase 4 3 4
  • Serine/Threonine Kinase 2 2 3
  • NIMA-Related Kinase 4 3 5
  • EC 2.7.11.1 4 63
  • STK2 3 4
  • Serine/Threonine-Protein Kinase Nek4 Variant 2 3
  • EC 2.7.11 63
  • Pp12301 3
  • NRK2 3

External Ids for NEK4 Gene

Previous HGNC Symbols for NEK4 Gene

  • STK2

Previous GeneCards Identifiers for NEK4 Gene

  • GC03M051836
  • GC03M051996
  • GC03M052599
  • GC03M052702
  • GC03M052719

Summaries for NEK4 Gene

GeneCards Summary for NEK4 Gene

NEK4 (NIMA Related Kinase 4) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK4 Gene

  • Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK4 Gene

Genomics for NEK4 Gene

Regulatory Elements for NEK4 Gene

Promoters for NEK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK4 Gene

Chromosome:
3
Start:
52,708,449 bp from pter
End:
52,770,949 bp from pter
Size:
62,501 bases
Orientation:
Minus strand

Genomic View for NEK4 Gene

Genes around NEK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK4 Gene

Proteins for NEK4 Gene

  • Protein details for NEK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51957-NEK4_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek4
    Protein Accession:
    P51957
    Secondary Accessions:
    • A5YM70
    • B2R633
    • B7Z200
    • Q6P576

    Protein attributes for NEK4 Gene

    Size:
    841 amino acids
    Molecular mass:
    94597 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with RPGRIP1 and RPGRIP1L.

    Alternative splice isoforms for NEK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK4 Gene

Proteomics data for NEK4 Gene at MOPED

Selected DME Specific Peptides for NEK4 Gene

Post-translational modifications for NEK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEK4 Gene

Domains & Families for NEK4 Gene

Gene Families for NEK4 Gene

Graphical View of Domain Structure for InterPro Entry

P51957

UniProtKB/Swiss-Prot:

NEK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK4: view

Function for NEK4 Gene

Molecular function for NEK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Enzyme Numbers (IUBMB) for NEK4 Gene

Gene Ontology (GO) - Molecular Function for NEK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030145 manganese ion binding ISS --
genes like me logo Genes that share ontologies with NEK4: view
genes like me logo Genes that share phenotypes with NEK4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEK4 Gene

Localization for NEK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK4 Gene

Cell projection, cilium. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK4 Gene COMPARTMENTS Subcellular localization image for NEK4 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for NEK4 Gene

Pathways & Interactions for NEK4 Gene

SuperPathways for NEK4 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with NEK4: view

Pathways by source for NEK4 Gene

1 Qiagen pathway for NEK4 Gene

Interacting Proteins for NEK4 Gene

Gene Ontology (GO) - Biological Process for NEK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006974 cellular response to DNA damage stimulus IMP 22851694
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0023014 signal transduction by protein phosphorylation IBA --
GO:0032147 activation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with NEK4: view

No data available for SIGNOR curated interactions for NEK4 Gene

Drugs & Compounds for NEK4 Gene

(2) Drugs for NEK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for NEK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK4: view

Transcripts for NEK4 Gene

Unigene Clusters for NEK4 Gene

NIMA-related kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6: -

Relevant External Links for NEK4 Gene

GeneLoc Exon Structure for
NEK4
ECgene alternative splicing isoforms for
NEK4

Expression for NEK4 Gene

mRNA expression in normal human tissues for NEK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEK4 Gene

This gene is overexpressed in Adipocyte (25.5), Testis (15.0), Tlymphocyte (12.4), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK4 Gene



SOURCE GeneReport for Unigene cluster for NEK4 Gene Hs.631921

mRNA Expression by UniProt/SwissProt for NEK4 Gene

P51957-NEK4_HUMAN
Tissue specificity: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
genes like me logo Genes that share expression patterns with NEK4: view

Protein tissue co-expression partners for NEK4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NEK4 Gene

Orthologs for NEK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEK4 35
  • 86.87 (n)
  • 81.65 (a)
NEK4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK4 35
  • 86.74 (n)
  • 82.32 (a)
NEK4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek4 35
  • 82.61 (n)
  • 77.75 (a)
Nek4 16
Nek4 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEK4 35
  • 99.35 (n)
  • 98.83 (a)
rat
(Rattus norvegicus)
Mammalia Nek4 35
  • 81.08 (n)
  • 77.55 (a)
oppossum
(Monodelphis domestica)
Mammalia NEK4 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK4 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK4 35
  • 65.24 (n)
  • 60.88 (a)
NEK4 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek4 35
  • 56.57 (n)
  • 53.02 (a)
Str.18724 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.18997 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nek4 35
  • 67.59 (n)
  • 70.36 (a)
nek4 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 37
  • 42 (a)
ZC581.1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for NEK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK4 Gene

ENSEMBL:
Gene Tree for NEK4 (if available)
TreeFam:
Gene Tree for NEK4 (if available)

Paralogs for NEK4 Gene

Paralogs for NEK4 Gene

genes like me logo Genes that share paralogs with NEK4: view

Variants for NEK4 Gene

Sequence variations from dbSNP and Humsavar for NEK4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1029871 - 52,763,618(-) TGCCA(C/G)CAATG reference, missense
rs35778416 - 52,763,576(+) TGTTC(C/T)TATCA reference, missense
rs56408749 - 52,763,542(+) CAGAC(A/G)GCCTT reference, missense
rs2230537 - 52,752,230(-) TACCA(C/T)AGAAC reference, missense
rs56019351 - 52,751,934(+) CACCT(C/G)GTCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NEK4 Gene

Variant ID Type Subtype PubMed ID
nsv508219 CNV Loss 20534489
nsv834698 CNV Gain 17160897
nsv508928 CNV Insertion 20534489

Variation tolerance for NEK4 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.57; 88.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK4 Gene

HapMap Linkage Disequilibrium report
NEK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK4 Gene

Disorders for NEK4 Gene

Relevant External Links for NEK4

Genetic Association Database (GAD)
NEK4
Human Genome Epidemiology (HuGE) Navigator
NEK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK4

No disorders were found for NEK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK4 Gene

Publications for NEK4 Gene

  1. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PMID: 8208544) Levedakou E.N. … Liu E.T. (Oncogene 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for NEK4 Gene

Sources for NEK4 Gene

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