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Aliases for NEK4 Gene

Aliases for NEK4 Gene

  • NIMA-Related Kinase 4 2 3
  • STK2 3 4 6
  • NIMA (Never In Mitosis Gene A)-Related Kinase 4 2 3
  • Serine/Threonine-Protein Kinase NRK2 3 4
  • Never In Mitosis A-Related Kinase 4 3 4
  • Serine/Threonine-Protein Kinase 2 3 4
  • Serine/Threonine Protein Kinase-2 2 3
  • NimA-Related Protein Kinase 4 3 4
  • Serine/Threonine Kinase 2 2 3
  • EC 4 64
  • NRK2 3 6
  • Serine/Threonine-Protein Kinase Nek4 Variant 2 3
  • Serine/Threonine-Protein Kinase Nek4 3
  • EC 2.7.11 64
  • Pp12301 3

External Ids for NEK4 Gene

Previous Symbols for NEK4 Gene

  • STK2

Summaries for NEK4 Gene

GeneCards Summary for NEK4 Gene

NEK4 (NIMA-Related Kinase 4) is a Protein Coding gene. Diseases associated with NEK4 include coffin-lowry syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK2.

UniProtKB/Swiss-Prot for NEK4 Gene

  • Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK4 Gene

Genomics for NEK4 Gene

Genomic Location for NEK4 Gene

52,708,449 bp from pter
52,770,949 bp from pter
62,501 bases
Minus strand

Genomic View for NEK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK4 Gene

Regulatory Elements for NEK4 Gene

Proteins for NEK4 Gene

  • Protein details for NEK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase Nek4
    Protein Accession:
    Secondary Accessions:
    • A5YM70
    • B2R633
    • B7Z200
    • Q6P576

    Protein attributes for NEK4 Gene

    841 amino acids
    Molecular mass:
    94597 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with RPGRIP1 and RPGRIP1L.

    Alternative splice isoforms for NEK4 Gene


neXtProt entry for NEK4 Gene

Proteomics data for NEK4 Gene at MOPED

Selected DME Specific Peptides for NEK4 Gene

Post-translational modifications for NEK4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NEK4 Gene

Domains for NEK4 Gene


  • Contains 1 protein kinase domain.:
    • P51957
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.:
    • P51957
genes like me logo Genes that share domains with NEK4: view

Function for NEK4 Gene

Molecular function for NEK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.

Enzyme Numbers (IUBMB) for NEK4 Gene

Gene Ontology (GO) - Molecular Function for NEK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK4: view
genes like me logo Genes that share phenotypes with NEK4: view

miRNA for NEK4 Gene

miRTarBase miRNAs that target NEK4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NEK4 Gene

Localization for NEK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK4 Gene

Cell projection, cilium. Cytoplasm.

Subcellular locations from

Jensen Localization Image for NEK4 Gene COMPARTMENTS Subcellular localization image for NEK4 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for NEK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm ISS --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with NEK4: view

Pathways for NEK4 Gene

SuperPathways for NEK4 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with NEK4: view

Pathways by source for NEK4 Gene

1 Qiagen pathway for NEK4 Gene

Interacting Proteins for NEK4 Gene

Gene Ontology (GO) - Biological Process for NEK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 22851694
GO:0006468 protein phosphorylation ISS --
GO:0006974 cellular response to DNA damage stimulus IMP 22851694
GO:0007067 mitotic nuclear division IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with NEK4: view

Compounds for NEK4 Gene

(3) HMDB Compounds for NEK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with NEK4: view

Transcripts for NEK4 Gene

Unigene Clusters for NEK4 Gene

NIMA-related kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - -
SP4: -
SP6: -

Relevant External Links for NEK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEK4 Gene

mRNA expression in normal human tissues for NEK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEK4 Gene

SOURCE GeneReport for Unigene cluster for NEK4 Gene Hs.631921

mRNA Expression by UniProt/SwissProt for NEK4 Gene

Tissue specificity: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas.
genes like me logo Genes that share expressions with NEK4: view

Orthologs for NEK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEK4 36
  • 99.35 (n)
  • 98.83 (a)
(Bos Taurus)
Mammalia NEK4 36
  • 86.87 (n)
  • 81.65 (a)
NEK4 37
  • 81 (a)
(Canis familiaris)
Mammalia NEK4 36
  • 86.74 (n)
  • 82.32 (a)
NEK4 37
  • 82 (a)
(Mus musculus)
Mammalia Nek4 36
  • 82.61 (n)
  • 77.75 (a)
Nek4 16
Nek4 37
  • 77 (a)
(Monodelphis domestica)
Mammalia NEK4 37
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia NEK4 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Nek4 36
  • 81.08 (n)
  • 77.55 (a)
(Gallus gallus)
Aves NEK4 36
  • 65.24 (n)
  • 60.88 (a)
NEK4 37
  • 59 (a)
(Anolis carolinensis)
Reptilia NEK4 37
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18997 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nek4 36
  • 56.57 (n)
  • 53.02 (a)
Str.18724 36
(Danio rerio)
Actinopterygii -- 36
nek4 36
  • 67.59 (n)
  • 70.36 (a)
nek4 37
  • 46 (a)
(Caenorhabditis elegans)
Secernentea Y39G10AR.4 38
  • 42 (a)
ZC581.1 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 68 (a)
Species with no ortholog for NEK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK4 Gene

Gene Tree for NEK4 (if available)
Gene Tree for NEK4 (if available)

Paralogs for NEK4 Gene

Paralogs for NEK4 Gene

genes like me logo Genes that share paralogs with NEK4: view

Variants for NEK4 Gene

Sequence variations from dbSNP and Humsavar for NEK4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11235 -- 52,711,071(-) CTTAA(A/G)CACAA utr-variant-3-prime
rs168675 -- 52,754,887(+) gctaa(A/C)atggt intron-variant
rs171549 -- 52,754,880(+) catcc(C/T)ggcta intron-variant
rs192191 -- 52,725,233(+) CAggc(C/G)gggcg intron-variant
rs246468 -- 52,713,615(+) catgg(A/T)gaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK4 Gene

Variant ID Type Subtype PubMed ID
nsv508219 CNV Loss 20534489
nsv834698 CNV Gain 17160897
nsv508928 CNV Insertion 20534489

Relevant External Links for NEK4 Gene

HapMap Linkage Disequilibrium report

Disorders for NEK4 Gene

(1) MalaCards Diseases for NEK4 Gene

Search for NEK4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NEK4 Gene

Relevant External Links for NEK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NEK4: view

No data available for UniProtKB/Swiss-Prot for NEK4 Gene

Publications for NEK4 Gene

  1. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PMID: 8208544) Levedakou E.N. … Liu E.T. (Oncogene 1994) 2 3 4
  2. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PMID: 19416921) Scott L.J. … Boehnke M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 49
  3. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. (PMID: 22851694) Nguyen C.L. … Hahn W.C. (Mol. Cell. Biol. 2012) 3 4
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 49
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49

Products for NEK4 Gene

  • Addgene plasmids for NEK4

Sources for NEK4 Gene

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