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NEK4 Gene

protein-coding   GIFtS: 60
GCID: GC03M052744

NIMA-Related Kinase 4

(Previous names: serine/threonine kinase 2, NIMA (never in mitosis gene a)-related...)
(Previous symbol: STK2)
  See NEK4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NIMA-Related Kinase 41 2     Serine/Threonine-Protein Kinase 22 3
STK21 2 3 5     Serine/Threonine-Protein Kinase NRK22 3
NIMA (Never In Mitosis Gene A)-Related Kinase 41 2     EC 2.7.11.13 8
Serine/Threonine Kinase 21 2     NRK22 5
Serine/Threonine Protein Kinase-21 2     pp123012
Never In Mitosis A-Related Kinase 42 3     Serine/Threonine-Protein Kinase Nek42
NimA-Related Protein Kinase 42 3     EC 2.7.118

External Ids:    HGNC: 113991   Entrez Gene: 67872   Ensembl: ENSG000001149047   OMIM: 6019595   UniProtKB: P519573   

Export aliases for NEK4 gene to outside databases

Previous GC identifers: GC03M051836 GC03M051996 GC03M052599 GC03M052702 GC03M052719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEK4 Gene:
NEK4 (NIMA-related kinase 4) is a protein-coding gene. Diseases associated with NEK4 include coffin-lowry syndrome. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK6.

UniProtKB/Swiss-Prot: NEK4_HUMAN, P51957
Function: Seems to act exclusively upon threonine residues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEK4 gene promoter:
         GR   Pax-5   MIF-1   Evi-1   MEF-2A   CREB   deltaCREB   POU2F1a   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK4 promoter sequence
   Search Chromatin IP Primers for NEK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

NEK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052744:  view genomic region     (about GC identifiers)

Start:
52,744,796 bp from pter      End:
52,804,965 bp from pter
Size:
60,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEK4_HUMAN, P51957 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek4  
Size: 841 amino acids; 94597 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: A5YM70 B2R633 B7Z200 Q6P576
Alternative splicing: 3 isoforms:  P51957-1   P51957-2   P51957-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK4: NX_P51957

Explore proteomics data for NEK4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NEK4 (P51957)
     ILHRDLK  GTPYYMSPE 


    See NEK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180462.1  NP_003148.2  

    ENSEMBL proteins: 
     ENSP00000233027   ENSP00000373227   ENSP00000419666   ENSP00000420231   ENSP00000417119  
     ENSP00000437703  

    NEK4 Human Recombinant Protein Products:

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    Novus Biologicals NEK4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEK4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 4
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P51957

    ProtoNet protein and cluster: P51957

    UniProtKB/Swiss-Prot: NEK4_HUMAN, P51957
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with NEK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK4_HUMAN, P51957
    Function: Seems to act exclusively upon threonine residues (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS8208544
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with NEK4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NEK4:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Nek4 (no phenotypes)

    Find genes that share phenotypes with NEK4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEK4

    miRNA
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    miRTarBase miRNAs that target NEK4:
    hsa-mir-197-3p (MIRT004215)

    Block miRNA regulation of human, mouse, rat NEK4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate NEK4:
    hsa-miR-3128 hsa-miR-885-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidNEK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEK4
    Predesigned siRNA for gene silencing in human, mouse, rat NEK4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NEK4 (NM_003157)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK4
    Addgene plasmids for NEK4 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEK4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEK4_HUMAN, P51957: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with NEK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEK4 About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NEK4
        Sperm Motility


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEK4
    Interactions:

        Search GeneGlobe Interaction Network for NEK4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NEK4 (ENSP000002330274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3ENSP000002630254STRING: ENSP00000263025
    MAPK1ENSP000002158324STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS8208544
    GO:0007067mitosis IEA--
    GO:0023014signal transduction by phosphorylation IBA--

    Find genes that share ontologies with NEK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEK4

    3 HMDB Compounds for NEK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEK4 gene (2 alternative transcripts): 
    NM_001193533.1  NM_003157.4  

    Unigene Cluster for NEK4:

    NIMA-related kinase 4
    Hs.631921  [show with all ESTs]
    Unigene Representative Sequence: NM_003157
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233027(uc003dfq.4 uc011bej.2) ENST00000383721(uc003dfr.3)
    ENST00000461689 ENST00000493199 ENST00000487068 ENST00000496822 ENST00000535191

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEK4 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate NEK4:
    hsa-miR-3128 hsa-miR-885-3p hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidNEK4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEK4
    Predesigned siRNA for gene silencing in human, mouse, rat NEK4
    Clone
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    OriGene clones in human, mouse for NEK4 (see all 10)
    OriGene ORF clones in mouse, rat for NEK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEK4 (NM_003157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK4
    Addgene plasmids for NEK4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NEK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEK4
      QuantiTect SYBR Green Assays in human, mouse, rat NEK4
      QuantiFast Probe-based Assays in human, mouse, rat NEK4

    Additional mRNA sequence: 

    AK294165.1 AK312420.1 BC015515.1 BC063044.1 EF560744.1 L20321.1 

    11 DOTS entries:

    DT.100792406  DT.412966  DT.100743995  DT.100792403  DT.120884085  DT.120884093  DT.120884143  DT.40106034 
    DT.86839863  DT.92427734  DT.95356092 

    Selected AceView cDNA sequences (see all 131):

    BU186968 AA205125 AA382899 AA678151 BM719078 CA418230 BP355774 BX282416 
    BQ212584 AA886466 BM748481 BP351736 AI561033 CB120617 CB269744 BE670907 
    CF272330 BE889895 AA888344 AA442692 CB159682 BM713549 AL044912 BX377921 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NEK4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                                                                                      -                                   -                       -         
    SP2:                                                                                -     -                                   -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NEK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTCCTCTG
    NEK4 Expression
    About this image


    NEK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
    NEK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631921

    UniProtKB/Swiss-Prot: NEK4_HUMAN, P51957
    Tissue specificity: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, liver,
    kidney, lung and placenta. Present in most primary carcinomas

        Custom PCR Arrays for NEK4
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    QuantiFast Probe-based Assays in human, mouse, rat NEK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NEK4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek41 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 82.61(n)1
    77.75(a)1
      14 (19.09 cM)5
    239551  NM_011849.21  NP_035979.11 
     309514885 
    chicken
    (Gallus gallus)
    Aves NEK41 NIMA (never in mitosis gene a)-related kinase 4 65.24(n)
    60.88(a)
      415900  XM_414252.4  XP_414252.2 
    lizard
    (Anolis carolinensis)
    Reptilia NEK46
    NIMA-related kinase 4
    56(a)
    1 ↔ 1
    2(154899994-154920263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189972 Xenopus laevis transcribed sequence with weak similarity more 77.96(n)    BJ626213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054633.12   -- 78.81(n)   393987  BC054633.1 


    ENSEMBL Gene Tree for NEK4 (if available)
    TreeFam Gene Tree for NEK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEK4 gene
    NEK62  NEK12  NEK112  NEK32  NEK72  NEK52  NEK22  NEK82  
    NEK102  NEK92  
    Selected SIMAP similar genes for NEK4 using alignment to 5 protein entries:     NEK4_HUMAN (see all proteins) (see all similar genes):
    TGM4    FLJ00047    C1orf143    EIF3G    pp12301    EEF1E1
    RHOA    ZNF737    EIF3K    ZNF738    EDRF1    FAM3A
    MLL5    TMEM14B    TNFRSF17    UBE2V2    ABI2    CALCOCO2

    Find genes that share paralogs with NEK4           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for NEK4
    PGOHUM00000238818 PGOHUM00000236930 PGOHUM00000236935 PGOHUM00000239040 PGOHUM00000249510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEK4 (see all 1217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409214
    A colorectal adenocarcinoma sample4--see VAR_0409212 R K mis40--------
    rs1435295361,2
    --52744324(+) TGCAGC/TGATCT 2 -- int10--------
    rs563598831,2
    C--52744381(+) GTCTT-/AAAAAA 2 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs612206671,2
    C,F--52744436(+) GTATTT/GGTGTG 2 -- int15Minor allele frequency- G:0.14WA CSA NA 244
    rs130790631,2
    C,F,H--52744460(+) CAAAGA/GTAGAT 2 -- int121Minor allele frequency- G:0.47NS EA NA WA CSA 2035
    rs1493053551,2
    C--52744493(+) AAAAC-/AGGGCTG 2 -- int10--------
    rs1509850101,2
    --52744865(+) AAGACG/TTGTAT 2 -- ut310--------
    rs1853300761,2
    --52744908(+) ATTACA/CTCTTA 2 -- ut310--------
    rs112351,2
    C,F,A,H--52745087(-) CTTAAA/GCACAA 2 -- ut3120Minor allele frequency- N:0.00MN EA NA NS WA 1629
    rs779330711,2
    C--52745465(+) TATAGC/TTCTGT 2 -- ut312Minor allele frequency- T:0.14CSA WA 120

    HapMap Linkage Disequilibrium report for NEK4 (52744796 - 52804965 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NEK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508928CNV Insertion20534489
    nsv508219CNV Loss20534489
    nsv834698CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEK4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601959    OMIM disorders: --

    1 disease for NEK4:    
    About MalaCards
    coffin-lowry syndrome

    1 disease from the University of Copenhagen DISEASES database for NEK4:
    Coffin-Lowry syndrome

    Find genes that share disorders with NEK4           About GenesLikeMe

    Genetic Association Database (GAD): NEK4
    Human Genome Epidemiology (HuGE) Navigator: NEK4 (4 documents)

    Export disorders for NEK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEK4 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with NEK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. (PubMed id 8208544)1, 2, 3 Levedakou E.N.... Liu E.T. (Oncogene 1994)
    2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)1, 4 Scott L.J....Boehnke M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    8. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. (PubMed id 22851694)1 Nguyen C.L....Hahn W.C. (Mol. Cell. Biol. 2012)
    9. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 (Nat. Genet. 2011)
    10. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. (PubMed id 21685204)1 Coene K.L....Roepman R. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6787 HGNC: 11399 AceView: NEK4 Ensembl:ENSG00000114904 euGenes: HUgn6787
    ECgene: NEK4 H-InvDB: NEK4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NEK4 gene:
    Search GeneIP for patents involving NEK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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