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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEK3 Gene

protein-coding   GIFtS: 59
GCID: GC13M052706

NIMA-related kinase 3

(Previous name: NIMA (never in mitosis gene a)-related kinase 3 )
 Explore 11 diseases affiliated with
NEK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NEK3    

Aliases
for NEK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NIMA-Related Kinase 31 2     MGC299491
HSPK361 2     Glycogen Synthase A Kinase2
NIMA (Never In Mitosis Gene A)-Related Kinase 31 2     Hydroxyalkyl-Protein Kinase2
Never In Mitosis A-Related Kinase 32 3     Phosphorylase B Kinase Kinase2
NimA-Related Protein Kinase 32 3     Serine/Threonine-Protein Kinase Nek32
HSPK 362 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 77461   Entrez Gene: 47522   Ensembl: ENSG000001360987   OMIM: 6040445   UniProtKB: P519563   
ORGUL members:         
NONCODE:n407859 n336591    

Export aliases for NEK3 gene to outside databases

Previous GC identifers: GC13U990024 GC13M046694 GC13M051643 GC13M050504 GC13M051604 GC13M033494


Summaries
for NEK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NEK3:
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded
protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the
cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide
exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms
have been found for this gene.(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: NEK3_HUMAN, P51956
Function: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules.
Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2.
Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms
involving RAC1 activation and phosphorylation of PXN and VAV2

Gene Wiki entry for NEK3


Genomic Views
for NEK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK3 gene promoter:
         PPAR-gamma1   HOXA3   AML1a   PPAR-gamma2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.13   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.2-q21.1

NEK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M052706:  view genomic region     (about GC identifiers)

Start:
 52,706,775 bp from pter      End:
 52,733,996 bp from pter
Size:
 27,222 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n407859
  • n336591
52706778 52720387 52733996 chr13

Proteins
for NEK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NEK3_HUMAN, P51956 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek3  
Size: 506 amino acids; 57705 Da
Cofactor: Magnesium
Subunit: Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent
Subcellular location: Cytoplasm (By similarity). Cell projection, axon (By similarity)
Sequence caution: Sequence=CAI12895.1; Type=Erroneous gene model prediction; Sequence=EAX08907.1; Type=Erroneous gene
model prediction;
Secondary accessions: A8K2J4 Q5TAP2 Q8J023 Q8WUN5
Alternative splicing: 2 isoforms:  P51956-1   P51956-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK3: NX_P51956

Post-translational modifications:

  • Phosphorylation at Thr-479 regulates its catalytic activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51956

    • 3 DME Specific Peptides for NEK3 (P51956)
     HRDIKSKN  KSDIWSLGC  MIGEGSFGR 

    NEK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139571.1  NP_002489.1  NP_689933.1  

    ENSEMBL proteins: 
     ENSP00000448782   ENSP00000449608   ENSP00000383210   ENSP00000448716   ENSP00000449055  
     ENSP00000447995   ENSP00000449679   ENSP00000404197   ENSP00000339429   ENSP00000367341  

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    Novus Biologicals NEK3 Proteins
    Novus Biologicals NEK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEK3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7522034
    GO:0005737cytoplasm IEA--
    GO:0030424axon IEA--


    NEK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NEK3

    Protein Domains /
    Families
    for NEK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NEK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P51956

    ProtoNet protein and cluster: P51956

    UniProtKB/Swiss-Prot: NEK3_HUMAN, P51956
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for NEK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NEK3_HUMAN, P51956
    Function: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules.
    Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2.
    Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms
    involving RAC1 activation and phosphorylation of PXN and VAV2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Prolactin stimulates its activity

         Genatlas biochemistry entry for NEK3:
    never in mitosis gene A-related kinase 3,predominantly cytoplasmic,widely expressed in a non dependent cell cycle
    pattern

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-miR-26b* hsa-let-7c hsa-let-7i hsa-miR-188-3p hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: NEK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Search LifeMap BioReagents cell lines for NEK3

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS7522034
    GO:0005515protein binding IPI15618286
    GO:0005524ATP binding NAS--
    GO:0046872metal ion binding IEA--


    NEK3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for NEK3:
     Decreased substrate adherent c  Increased apoptosis  Increased cell death HMECs cel  Increased number of small and  


    Pathways & Interactions
    for NEK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Prolactin receptor signaling
    		Development Prolactin receptor signaling1.00
    		Prolactin Signaling Pathway0.39
    		Development_Prolactin receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NEK3
        Development Prolactin receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for NEK3
        Development Prolactin receptor signaling

    1 BioSystems Pathway for NEK3 
        Prolactin Signaling Pathway



    NEK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for NEK3 (P519561, 3 ENSP000003832104) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAV2P527351, 3, ENSP000003609164EBI-476041,EBI-297549 I2D: score=2 STRING: ENSP00000360916
    VAV1P154983, ENSP000003022694I2D: score=1 STRING: ENSP00000302269
    CSN2P058143, ENSP000003410304I2D: score=1 STRING: ENSP00000341030
    PRLRP164713, ENSP000003714324I2D: score=3 STRING: ENSP00000371432
    BPGMENSP000003420324STRING: ENSP00000342032
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS--
    GO:0007049cell cycle NAS--
    GO:0007067mitosis NAS7522034
    GO:0051301cell division IEA--


    NEK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NEK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NEK3

    3 HMDB Compounds for NEK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    5 Novoseek chemical compound relationships for NEK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 72.7 8 1905390 (1), 10832587 (1), 10487978 (1), 2122111 (1) (see all 5)
    lactate 27.2 2 15199064 (1), 8795843 (1)
    creatinine 7.05 1 15199064 (1)
    calcium 5.32 3 9334188 (1), 2122111 (1)
    serine 0 2 15618286 (1)

    Search CenterWatch for drugs/clinical trials and news about NEK3 

    Transcripts
    for NEK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NEK3 gene (3 alternative transcripts): 
    NM_001146099.1  NM_002498.2  NM_152720.2  

    Unigene Cluster for NEK3:

    NIMA-related kinase 3
    Hs.409989  [show with all ESTs]
    Unigene Representative Sequence: AK131359
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258597 ENST00000548127(uc010tgx.2 uc010tgy.2) ENST00000550331
    ENST00000400357 ENST00000547422 ENST00000547820 ENST00000551355 ENST00000552973
    ENST00000550841 ENST00000452082(uc001vgh.3) ENST00000339406 ENST00000378101(uc001vgi.3)


    miRNA
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    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-miR-26b* hsa-let-7c hsa-let-7i hsa-miR-188-3p hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: NEK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB072828.1 AK131359.1 AK290259.1 BC019916.1 NR_027415.1 Z25434.1 Z29067.1 

    8 DOTS entries:

    DT.114332  DT.100786893  DT.100715201  DT.95351264  DT.100661681  DT.100786890  DT.120793542  DT.75116772 

    24/102 AceView cDNA sequences (see all 102):

    BU608251 CR612915 AA429561 AI393796 AW043698 BQ432111 AK131359 CF529717 
    CB215347 AI141017 AI885400 AI801489 AB072828 CR606903 BX395060 BM662593 
    AI248318 NM_002498 BM696814 BQ648157 BU622080 AL833951 NM_152720 AI360208 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NEK3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:        -     -                                                                                                                     
    SP2:                                                                                            -                                       
    SP3:                          -                                                                                                         
    SP4:                                                                                            -                 -                     
    SP5:              -                                                                                                                     


    ECgene alternative splicing isoforms for NEK3

    Expression
    for NEK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGACGTATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NEK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEK3

    SOURCE GeneReport for Unigene cluster: Hs.409989

    UniProtKB/Swiss-Prot: NEK3_HUMAN, P51956
    Tissue specificity: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression
    in testis, ovary and brain

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    In Situ
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    Orthologs
    for NEK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NEK3 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NEK31 NIMA (never in mitosis gene a)-related kinase 3 69.33(n)
    64.96(a)    		   770196  XM_001232685.2  XP_001232686.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NEK36
    		 --
    		 59(a)
    		 1 ↔ 1
    		 1(132744470-132762288)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.199642 Transcribed sequence with weak similarity to protein more 77.7(n)    CF221766.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01040556.16
    si:dkey-201l21.26
    (see all 11)    		 si:dkey-201l21.2
    (see all 11)    		 66(a)
    6(a)
    (see all 11)    		 1 ↔ 1
    possible ortholog
    (see all 11)    		 15(3502177-3509891)
    7(3466027-3477481)


    ENSEMBL Gene Tree for NEK3 (if available)
    TreeFam Gene Tree for NEK3 (if available) 

    Paralogs
    for NEK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEK3 gene
    NEK42  NEK62  NEK12  NEK112  NEK72  NEK52  NEK22  NEK82  
    NEK102  NEK92  
    18/60 SIMAP similar genes for NEK3 using alignment to 8 protein entries:     NEK3_HUMAN (see all proteins) (see all similar genes):
    DKFZp434B079    DKFZp564L2416    NEK5    NEK1    NEK9    NEK8
    NEK4    SGK2    RPS6KA3    NEK6    MARK4    CDC42BPA
    STK11    RPS6KA6    NEK7    PRKACB    NEK11    AKT1

    NEK3 for paralogs           About GeneDecksing



    Genomic Variants
    for NEK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/482 NCBI SNPs in NEK3 are shown (see all 482)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs18865421,2
    		C,F,A,H,--52706281(-) ACATCT/GTTTAA 4 -- ds5001 int120Minor allele frequency- G:0.37NS EA NA CSA WA 2340
    rs1177634081,2
    		F,--52706384(+) GCTCAC/TGTCTC 4 -- ds5001 int11Minor allele frequency- T:0.02NA 120
    rs1911499721,2
    		--52706390(+) GTCTCC/TTTGAG 4 -- ds5001 int10--------
    rs1997662911,2
    		--52706392(+) CTCTT-/TGAGAGG 4 -- ds5001 int10--------
    rs1385712211,2
    		--52706403(+) GTGTTC/GAGCGA 4 -- ds5001 int10--------
    rs1824582611,2
    		--52706433(+) ATATTC/GTCATC 4 -- ds5001 int10--------
    rs562630931,2
    		C,--52706454(+) GCACAC/GTATTA 4 -- ds5001 int12Minor allele frequency- G:0.04WA 120
    rs735001751,2
    		C,--52706497(+) TGTGCG/ACCATG 4 -- ds5001 int12Minor allele frequency- A:0.04WA 120
    rs1883266641,2
    		--52706516(+) TATTCA/GTTCCA 4 -- ds5001 int10--------
    rs1416729311,2
    		--52706546(+) ATATTC/TACCAT 4 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for NEK3 (52706775 - 52733996 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NEK3: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NEK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NEK3 for disorders           About GeneDecksing

    OMIM gene information: 604044    OMIM disorders: --

    11 diseases for NEK3:    About MalaCards
    muscle phosphorylase kinase deficiency    glycogen storage disease    muscle glycogenosis    paine syndrome
    cystic fibrosis    fanconi syndrome    fibrosis    myopathy
    breast cancer    malaria    neuronitis

    5 Novoseek disease relationships for NEK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen storage disease 87 7 1905390 (1), 10832587 (1), 9847997 (1), 9019646 (1) (see all 6)
    glycogen storage disease type i 72.9 3 8362811 (2), 1905390 (1)
    enzyme deficiency 69.6 2 9847997 (1), 8795843 (1)
    hepatomegaly 55.6 1 2252364 (1)
    hypoglycemia 31.3 1 7562285 (1)

    Human Genome Epidemiology (HuGE) Navigator: NEK3 (2 documents)

    Export disorders for NEK3 gene to outside databases

    Publications
    for NEK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEK3 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with NEK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. (PubMed id 7522034)1, 2, 3, 9 Schultz S.J.... Nigg E.A. (1994)
    2. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)1, 2, 3 Schultz S.J. and Nigg E.A. (1993)
    3. Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. (PubMed id 15618286)1, 2, 9 Miller S.L....Clevenger C.V. (2005)
    4. Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). (PubMed id 12063396)1, 2, 9 Kimura M. and Okano Y. (2001)
    5. Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. (PubMed id 17297458)1, 2 Miller S.L....Clevenger C.V. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. (PubMed id 21756249)1 Benjamin S....Horowitz M. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)

    External Searches for NEK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NEK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4752 HGNC: 7746 AceView: NEK3 Ensembl:ENSG00000136098 euGenes: HUgn4752
    ECgene: NEK3 H-InvDB: NEK3

    Other Databases showing NEK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NEK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NEK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NEK3 gene:
    Search GeneIP for patents involving NEK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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