NEK2 Gene
protein-coding GIFtS : 67 GCID: GC01 M211836
NIMA-related kinase 2 NIMA (never in mitosis gene a)-related kinase 2 )
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Aliasesfor NEK2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases NIMA-Related Kinase 2 1 2 EC 2.7.11.13 8 NEK2A1 2 3 HsPK212 NLK11 2 3 Serine/Threonine-Protein Kinase Nek22 NIMA (Never In Mitosis Gene A)-Related Kinase 21 2 HSPK 213 NimA-Like Protein Kinase 12 3 Never In Mitosis A-Related Kinase 23 NimA-Related Protein Kinase 22 3 EC 2.7.118
Export aliases for NEK2 gene to outside databases Previous GC identifers: GC01M210565 GC01M207702 GC01M208475 GC01M208915 GC01M208224 GC01M209902 GC01M182513
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Summariesfor NEK2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NEK2 : This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. (provided by RefSeq, Feb 2011) UniProtKB/Swiss-Prot: NEK2_HUMAN, P51955 Function : Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation inmitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not Gene Wiki entry for NEK2
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Genomic Viewsfor NEK2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167186.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NEK2 gene promoter:Bach1 C/EBPbeta Bach2 E47 MEF-2A CBF-A Hand1 Cart-1 aMEF-2 CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for NEK2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.2-q41 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q32-q42 NEK2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M211836: view genomic region
(about GC identifiers )
Start: 211,836,114 bp from pter End:
211,848,967 bp from pter
Size: 12,854 bases Orientation:
minus strand
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Proteinsfor NEK2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NEK2_HUMAN, P51955 See
protein sequence )Recommended Name: Size : 445 amino acids; 51763 DaCofactor : MagnesiumSubunit : Isoform 1, isoform 2 and isoform 4 form homo- and heterodimers. Interacts with NECAB3 and HMGA2 (Bysimilarity). Isoform 1 interacts with CDC20, CTNB1, MAD1L1, MAPK, NEK11, NPM1, NDC80, PCNT and SGOL1. Isoform 1 interacts with STK3/MST2 (via SARAH domain) and SAV1 (via SARAH domain). Isoform 1 and isoform 2 interact with MAD2L1. Isoform 1 and isoform 4 interact with PPP1CA and PPP1CC
Subcellular location : Isoform 1: Nucleus. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome.Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere (By similarity). Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Co-localizes with SGOL1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end
Subcellular location : Isoform 2: Cytoplasm. Note=Predominantly cytoplasmicSubcellular location : Isoform 4: Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Predominantly nuclearSequence caution : Sequence=AAH65932.1; Type=Frameshift; Positions=213;6/20 PDB 3D structures from (see all 20 ):2JAV (3D) 2W5A (3D) 2W5B (3D) 2W5H (3D) 2WQO (3D) 2XK3 (3D) Secondary accessions : Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9Alternative splicing : 4 isoforms : P51955-1 P51955-2 P51955-3 P51955-4 Explore the universe of human proteins at neXtProt for NEK2: NX_P51955 Post-translational modifications:
Activated by autophosphorylation. Protein phosphatase 1 represses autophosphorylation and activation of isoform 1 by dephosphorylation. Phosphorylation by STK3/MST2 is necessary for its localization to the centrosome1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P51955 4 DME Specific Peptides for NEK2 (P51955 ) NEK2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001191111.1 NP_001191112.1 NP_002488.1 ENSEMBL proteins: ENSP00000355966 ENSP00000355965 ENSP00000440237 Reactome Protein details: P51955 Human Recombinant Protein Products: Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing NEK2 Antibody Products: Assay Products for NEK2:
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Protein
Domains /for NEK2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P51955 ProtoNet protein and cluster: P51955
UniProtKB/Swiss-Prot: NEK2_HUMAN, P51955 Domain : The leucine-zipper domain is required for its dimerization and activationSimilarity : Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamilySimilarity : Contains 1 protein kinase domain
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Functionfor NEK2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: NEK2_HUMAN, P51955 Function : Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation inmitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Isoform 1 is inhibited by ionizing radiation in the presence of PPP1CA. Its catalytic activity isinhibited by the inhibitor CCT241950. In the presence of this inhibitor, displays an autoinhibited conformation: Tyr-70 side chain points into the active site, interacts with the activation loop, and blocks the alphaC helix Induction : Expression and activity peak in the G2 phase of the mitotic cycle and decrease once the cells have enteredmitosis due to degradation by the anaphase promoting complex APC/C-CDC20. In G1 phase, both isoform 1 and isoform 2 are almost undetectable. However, at the G1/S transition, there is an increase in expression of both isoforms which then remain at this increased level throughout S and G2. At the onset of mitosis, isoform 1 undergoes a rapid disappearance whereas isoform 2 continues to be present at about the same level as in G2. During the rest of mitosis, isoform 1 remains absent, while isoform 2 only begins to decline upon re-entry into the next G1 phase
Genatlas biochemistry entry for NEK2 never in mitosis gene A-related kinase 2,Aspergillus nidulans NIMA ortholog,located to the centrosome,expressed in a cell-cycle dependent pattern,undetectable during G1,appearing in S,reacting maximum levels in late G2 Enzyme Numbers (IUBMB): EC 2.7.11.1 1 2 EC 2.7.11 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): NEK2 (NM_001204183 ) Sino Biological Human cDNA Clone for NEK2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEK2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK2
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for NEK2 :
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Pathways & Interactionsfor NEK2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Recruitment of mitotic centrosome proteins and complexes 2 Cell cycle_Spindle assembly and chromosome separation 3 APC-Cdc20 mediated degradation of Nek2A 4 Cell Cycle 5 Cell cycle Role of APC in cell cycle regulation
Pathway sources See GeneCards unified pathways Show all pathways 2 2 1 5/10 (see all 10 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/135 Interacting proteins for NEK2 (P51955 1 , 2 , 3 ENSP00000355966 4 via UniProtKB, MINT, STRING , and/or I2D (see all 135 )Interactant Interaction Details GeneCard External ID(s) NEK11 Q8NG66 1 , 3 ENSP00000372857 4 EBI-4311380,EBI-633195 I2D:
score=3 STRING: ENSP00000372857 C10orf137 Q3B7T1 2 , 3 ENSP00000336727 4 MINT-8263621 I2D:
score=2 STRING: ENSP00000336727 DCTN1 Q14203 2 , 3 ENSP00000354791 4 MINT-8263654 I2D:
score=2 STRING: ENSP00000354791 PDE4DIP Q5VU43 2 , 3 ENSP00000358360 4 MINT-8263731 I2D:
score=2 STRING: ENSP00000358360 C12orf52 Q96K30 2 , 3 ENSP00000266813 4 MINT-8094886 I2D:
score=1 STRING: ENSP00000266813
About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000070 mitotic sister chromatid segregation
IEA -- GO:0000086 G2/M transition of mitotic cell cycle
TAS -- GO:0000278 mitotic cell cycle
TAS -- GO:0001824 blastocyst development
IEA -- GO:0006468 protein phosphorylation
IDA --
About GeneDecksing
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Drugs & Compoundsfor NEK2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for NEK2 3 HMDB Compounds for NEK2 About this table 1 DrugBank Compound for NEK2 About this table 2 Novoseek chemical compound relationships for NEK2 gene About this table NEK2
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Transcriptsfor NEK2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NEK2 gene (3 alternative transcripts): NM_001204182.1 NM_001204183.1 NM_002497.3 Unigene Cluster for NEK2:
NIMA-related kinase 2 Hs.153704 [show with all ESTs ] Unigene Representative Sequence: BC043502 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000366999 (uc021pir.1 uc021piq.1 uc001hir.2 uc001hit.2 )ENST00000462283 ENST00000489633 ENST00000366998 (uc001his.4 ) ENST00000540251 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): NEK2 (NM_001204183 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEK2
Additional cDNA sequence: AK223353.1 AK225522.1 AK303092.1 AY045701.1 AY863109.1 BC043502.1 BC052807.1 BC065932.1 BT019729.1 DQ786247.1 DQ786281.1 U11050.1 Z25425.1 Z29066.1
8 DOTS entries : DT.114738 DT.100783245
DT.100783250 DT.95275694 DT.100009881 DT.100783248 DT.95275695 DT.99990184 24/133 AceView cDNA sequences (see all 133 ):
BU517064 CR593900 BC043502 NM_002497 AA682321 AU131125 CB163013 AI572577 AI074569 BC052807 BQ431771 AI470415 CR601480 BC065932 BX368912 BM800724 BQ227186 BG771044 D80285 BI223141 AL516673 BM853783 BX368913 U11050 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NEK2 (see all 7 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e SP1 : - - - SP2 : - - - - SP3 : - - - - SP4 : - - - - - - - SP5 : - - - -
ECgene alternative splicing isoforms for NEK2
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Expression for NEK2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NEK2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image NEK2 expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category PureStem™ progenitor E44 (Embryonic Progenitor Cell)Primitive gut tube-like cells (A scalable, suspensi... )Expression: Experimental details:
In-situ hybridization
See NEK2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NEK2 SOURCE GeneReport for Unigene cluster: Hs.153704 UniProtKB/Swiss-Prot: NEK2_HUMAN, P51955 Tissue specificity : Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformedcell types. Isoform 1 and isoform 4 are expressed in the testis. Up-regulated in various cancer cell lines, as well as primary breast tumors SABiosciences Custom PCR Arrays for NEK2 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK2
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Orthologsfor NEK2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for NEK2 gene from 5/27 species (see all 27 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves NEK21
NIMA (never in mitosis gene a)-related kinase 2
71.63(n) 77.43(a)
421376 NM_001031050.1 NP_001026221.1
lizard Reptilia NEK26
--
78(a)
1 ↔ 1
1(238096772-238109849)
African clawed frog Amphibia MGC532022
similar to NIMA (never in mitosis gene a)-related kinase more
74.16(n)
AB019556.1
zebrafish Actinopterygii zgc556022
similar to NIMA (never in mitosis gene a)-related kinase more
75.99(n)
394025 BC048055.1
fruit fly Insecta Nek21 3
mitosis protein serine/threonine kinase3 1
48(a) 3 49.55(n) 1 44.25(a) 1
7C13 31696 1 NM_132187.2 1 NP_572415.1 1
ENSEMBL Gene Tree for NEK2 (if available)TreeFam Gene Tree for NEK2 (if available)
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Paralogsfor NEK2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NEK2 gene NEK5 2 NEK8 2 NEK10 2 NEK4 2 NEK6 2 NEK1 2 NEK11 2 NEK3 2 NEK9 2 NEK7 2 18/20 SIMAP similar genes for NEK2 using alignment to 2 protein entries: NEK2_HUMAN (see all proteins )
(see all similar genes ):NEK6 NEK5 NEK7 MARK4 DKFZp564L2416 NEK8 PRKAA1 NEK3 MST094 NEK9 RPS6KA2 NEK1 NUAK1 DKFZp434B079 PAK4 STK11 CDK4 NEK11 About GeneDecksing 4 Pseudogenes.org Pseudogenes for NEK2 PGOHUM00000247698 PGOHUM00000248029 PGOHUM00000246368 PGOHUM00000240306
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Genomic Variantsfor NEK2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for NEK2 (211836114 - 211848967 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NEK2: --
SABiosciences Cancer Mutation PCR Assays
1 SABiosciences qBiomarker Copy Number PCR Array containing NEK2 :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor NEK2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 604043
OMIM disorders : --9 : About MalaCards van der woude syndrome male infertility seminoma infertility breast cancer breast carcinoma neuroblastoma carcinoma malaria 3 Novoseek disease relationships for NEK2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: NEK2 (5 documents) Export disorders for NEK2 gene to outside databases
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Publicationsfor NEK2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NEK2 gene, integrated from 9 sources (see all 99 ):(articles sorted by number of sources associating them with NEK2) Utopia : connect your pdf to the dynamic
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451) 1 , 2 , 3(1993) Protein phosphatase-1alpha regulates centrosome splitting through Nek2. (PubMed id 17283141) 1 , 2 , 9(2007) Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. (PubMed id 7522034) 1 , 2 , 9(1994) beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858) 1 , 2 , 9(2008) Structure and regulation of the human Nek2 centrosomal kinase. (PubMed id 17197699) 1 , 2 , 9(2007) Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis. (PubMed id 11742531) 1 , 2 , 9(2002) An undecided coiled-coil: the leucine zipper of NEK2 kinase exhibits atypical conformational exchange dynamics. (PubMed id 21669869) 1 , 2 (2011) Involvement of a centrosomal protein kendrin in the m aintenance of centrosome cohesion by modulating Nek2A kinase activity. (PubMed id 20599736) 1 , 2 (2010) Components of the Hippo pathway cooperate with Nek2 k inase to regulate centrosome disjunction. (PubMed id 21076410) 1 , 2 (2010) The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. (PubMed id 18297113) 1 , 2 (2008)
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External Searches for NEK2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NEK2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing NEK2 gene
(According to HUGE )
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Specialized Databases showing NEK2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for NEK2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NEK2 gene: NEK2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NEK2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for NEK2 OriGene shRNA RFP for NEK2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for NEK2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NEK2 OriGene 3'-UTR Clone for NEK2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NEK2 OriGene Custom Protein Services for NEK2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEK2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for NEK2
NEK2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK2
ThermoFisher Antibodies for NEK2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NEK2
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and Proteopedia 
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BioSystems Pathway for NEK2 
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
