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NEK11 Gene

protein-coding   GIFtS: 55
GCID: GC03P130745

NIMA-Related Kinase 11

(Previous name: NIMA (never in mitosis gene a)- related kinase 11)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NIMA-Related Kinase 111 2     Never In Mitosis A-Related Kinase 113
NIMA (Never In Mitosis Gene A)- Related Kinase 111 2     NimA-Related Protein Kinase 113
Serine/Threonine-Protein Kinase Nek112     EC 2.7.118
EC 2.7.11.13     

External Ids:    HGNC: 185931   Entrez Gene: 798582   Ensembl: ENSG000001146707   OMIM: 6097795   UniProtKB: Q8NG663   

Export aliases for NEK11 gene to outside databases

Previous GC identifers: GC03P127657 GC03P131462 GC03P132027 GC03P132066 GC03P132228 GC03P128129


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEK11 Gene:
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the
nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA
replication and response to genotoxic stress. Alternatively spliced transcript variants have been
described.(provided by RefSeq, Mar 2009)

GeneCards Summary for NEK11 Gene:
NEK11 (NIMA-related kinase 11) is a protein-coding gene. Diseases associated with NEK11 include cerebritis. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot: NEK11_HUMAN, Q8NG66
Function: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls
degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for
BTRC-mediated polyubiquitination and degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEK11 gene promoter:
         SRF   C/EBPbeta   ATF-2   Nkx2-5   LCR-F1   HNF-1A   GATA-2   CRE-BP1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEK11 promoter sequence
   Search Chromatin IP Primers for NEK11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

NEK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P130745:  view genomic region     (about GC identifiers)

Start:
130,745,694 bp from pter      End:
131,069,309 bp from pter
Size:
323,616 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEK11_HUMAN, Q8NG66 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek11  
Size: 645 amino acids; 74192 Da
Cofactor: Manganese or magnesium
Subunit: Interacts with isoform 1 of NEK2
Developmental stage: Predominantly expressed at S/G2/M phase
Sequence caution: Sequence=BAB15672.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NHD7 Q5JPC0 Q8NG65 Q8TBY1 Q9H5F4
Alternative splicing: 4 isoforms:  Q8NG66-1   Q8NG66-2   Q8NG66-3   Q8NG66-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK11: NX_Q8NG66

Explore proteomics data for NEK11 at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NEK11 (Q8NG66)
     LKIGDFG  ILHRDLK 


    See NEK11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139475.1  NP_079076.3  NP_665917.1  

    ENSEMBL proteins: 
     ENSP00000421549   ENSP00000423458   ENSP00000425114   ENSP00000372857   ENSP00000425662  
     ENSP00000421192   ENSP00000426662   ENSP00000421851   ENSP00000473422   ENSP00000397180  
     ENSP00000349389   ENSP00000411888  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NIMA-related kinase 11
    NIMA (never in mitosis gene a)- related kinase (NEK) family

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8NG66

    ProtoNet protein and cluster: Q8NG66

    UniProtKB/Swiss-Prot: NEK11_HUMAN, Q8NG66
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    NEK11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEK11_HUMAN, Q8NG66
    Function: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls
    degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for
    BTRC-mediated polyubiquitination and degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Autorepressed by intramolecular binding of the C-terminus which dissociates following
    phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus,
    and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15161910
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15161910
    GO:0005524ATP binding IDA15161910
         
    NEK11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEK11:
     Decreased substrate adherent c 

    Animal Models:
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    hsa-miR-1290 hsa-miR-1255a hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEK11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEK11_HUMAN, Q8NG66: Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar
    microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    NEK11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEK11
    Interactions:

        GeneGlobe Interaction Network for NEK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEK11 (Q8NG661, 3 ENSP000003728574) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK2P519551, 3, ENSP000003559664EBI-633195,EBI-633182 I2D: score=3 STRING: ENSP00000355966
    PDPK1ENSP000003442204STRING: ENSP00000344220
    RAD1ENSP000003408794STRING: ENSP00000340879
    SFNENSP000003409894STRING: ENSP00000340989
    YWHABENSP000003001614STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA15161910
    GO:0031572G2 DNA damage checkpoint IMP19734889
    GO:0031573intra-S DNA damage checkpoint IDA15161910
    GO:0035556intracellular signal transduction IDA15161910

    NEK11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for NEK11

    4 HMDB Compounds for NEK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEK11 gene (3 alternative transcripts): 
    NM_001146003.1  NM_024800.4  NM_145910.3  

    Unigene Cluster for NEK11:

    NIMA-related kinase 11
    Hs.657336  [show with all ESTs]
    Unigene Representative Sequence: NM_024800
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000510769 ENST00000506695(uc003enw.1 uc011blm.2) ENST00000510688
    ENST00000511262(uc003enx.3) ENST00000383366(uc003eny.3) ENST00000513550
    ENST00000514915 ENST00000510474 ENST00000507967 ENST00000507910 ENST00000508196
    ENST00000602792 ENST00000426022 ENST00000510926 ENST00000515636 ENST00000510823
    ENST00000429253(uc003eoa.3 uc003enz.3 uc011blk.2 uc011bll.2)
    ENST00000356918(uc010hto.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate NEK11:
    hsa-miR-1290 hsa-miR-1255a hsa-miR-1255b
    SwitchGear 3'UTR luciferase reporter plasmidNEK11 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NEK11

    Additional mRNA sequence: 

    AB071996.1 AB071997.1 AK027148.1 AK123021.1 AK293261.1 AK297300.1 AK316352.1 AL833472.1 
    BC009414.1 BC026195.1 BC028587.2 

    12 DOTS entries:

    DT.412911  DT.99940186  DT.101980867  DT.100741330  DT.99971845  DT.92421362  DT.100741329  DT.100747846 
    DT.100776052  DT.100776053  DT.65285662  DT.97828907 

    Selected AceView cDNA sequences (see all 71):

    AK027148 BQ002569 CD106568 BU622115 AW027268 AK123021 AL833472 BC028587 
    AI288082 BI962897 CR599596 AA393085 CK903564 NM_145910 BX365473 AB071997 
    BG198954 AI057303 BX350324 BM979695 AW299861 BM998637 BG199484 BG185510 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NEK11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                            -                                               -                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for NEK11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTAATAAGG
    NEK11 Expression
    About this image


    NEK11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    NEK11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEK11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657336

    UniProtKB/Swiss-Prot: NEK11_HUMAN, Q8NG66
    Tissue specificity: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEK11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nek111 , 5 NIMA (never in mitosis gene a)-related expressed kinase more1, 5 80.83(n)1
    76.94(a)1
      9 (56.61 cM)5
    2085831  NM_172461.31  NP_766049.21 
     1051624675 
    chicken
    (Gallus gallus)
    Aves NEK111 NIMA (never in mitosis gene a)- related kinase 11 71.7(n)
    70.67(a)
      100857506  XM_003640741.2  XP_003640789.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEK116
    NIMA-related kinase 11
    63(a)
    1 ↔ 1
    6(37238498-37384842)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nek111 NIMA-related kinase 11 65.53(n)
    61.95(a)
      779890  NM_001078968.1  NP_001072436.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018830261 serine/threonine-protein kinase Nek11-like 59.69(n)
    55.54(a)
      101883026  XM_005158267.1  XP_005158324.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nekl-16
    Protein NEKL-1 (nekl-1) mRNA, complete cds
    14(a)
    many ↔ many
    I(2357883-2372964) WBGene00021461


    ENSEMBL Gene Tree for NEK11 (if available)
    TreeFam Gene Tree for NEK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEK11 gene
    NEK42  NEK62  NEK12  NEK32  NEK72  NEK52  NEK22  NEK82  
    NEK102  NEK92  
    Selected SIMAP similar genes for NEK11 using alignment to 5 protein entries:     NEK11_HUMAN (see all proteins) (see all similar genes):
    DKFZp564L2416    ABL1    NEK7    RPS6KA3    NEK3    NEK6
    DKFZp434B079    MST094    NEK10    CHEK2    RPS6KA2    STK11
    HUNK    NEK4    PRKACB    STK36    MYO3A    STK25

    NEK11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEK11 (see all 6005)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409414
    A colorectal adenocarcinoma sample4--see VAR_0409412 E K mis40--------
    VAR_0409444
    A colorectal adenocarcinoma sample4--see VAR_0409442 D N mis40--------
    VAR_0409354
    A colorectal adenocarcinoma sample4--see VAR_0409352 T M mis40--------
    rs2014312541,2
    --128140209(+) CATTT-/TTTGGG
            
    TTTGT
    3 -- cds10--------
    rs107141611,2
    C--128143030(+) TTTAC-/TTCCAC 3 -- int11Minor allele frequency- T:0.00NA 2
    rs1395096301,2
    C--128143287(+) AAAAA-/ACACCC 3 -- int10--------
    rs3703597681,2
    C--128147437(+) AAAGG-/GGGGGG 3 -- int10--------
    rs559339141,2
    C,F--128147439(+) GGTGGG/TGGGGG 3 -- int12Minor allele frequency- T:0.50NA WA 4
    rs2018974561,2
    C--128173319(+) ATAAT-/AAAAAA 3 -- int10--------
    rs2015235081,2
    C--128183385(+) TGTGTG/TTGTGT 3 -- int10--------

    HapMap Linkage Disequilibrium report for NEK11 (130745694 - 130995694 bp, first 250kb of NEK11)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NEK11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667216CNV Deletion23128226
    esv2725916CNV Deletion23290073
    nsv4006CNV Insertion18451855
    nsv524200CNV Loss19592680
    nsv877499CNV Loss21882294
    nsv877498CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609779    OMIM disorders: --

    1 disease for NEK11:    
    About MalaCards
    cerebritis


    NEK11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEK11
    Human Genome Epidemiology (HuGE) Navigator: NEK11 (3 documents)

    Export disorders for NEK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NEK11 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with NEK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. (PubMed id 12154088)1, 2, 9 Noguchi K.... Uehara Y. (J. Biol. Chem. 2002)
    2. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. (PubMed id 19734889)1, 2, 9 Melixetian M.... Helin K. (Nat. Cell Biol. 2009)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. (PubMed id 20090422)1, 2 Soerensen C.S.... Helin K. (Cell Cycle 2010)
    5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. (PubMed id 15161910)1, 2 Noguchi K.... Uehara Y. (J. Biol. Chem. 2004)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79858 HGNC: 18593 AceView: NEK11 Ensembl:ENSG00000114670 euGenes: HUgn79858
    ECgene: NEK11 H-InvDB: NEK11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEK11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NEK11 gene:
    Search GeneIP for patents involving NEK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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