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Aliases for NEK11 Gene

Aliases for NEK11 Gene

  • NIMA Related Kinase 11 2 3 5
  • NIMA (Never In Mitosis Gene A)- Related Kinase 11 2
  • Never In Mitosis A-Related Kinase 11 4
  • NimA-Related Protein Kinase 11 4
  • EC 2.7.11.1 4
  • EC 2.7.11 61

External Ids for NEK11 Gene

Previous GeneCards Identifiers for NEK11 Gene

  • GC03P127657
  • GC03P131462
  • GC03P132027
  • GC03P132066
  • GC03P132228
  • GC03P130745
  • GC03P128129

Summaries for NEK11 Gene

Entrez Gene Summary for NEK11 Gene

  • This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

GeneCards Summary for NEK11 Gene

NEK11 (NIMA Related Kinase 11) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK4.

UniProtKB/Swiss-Prot for NEK11 Gene

  • Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK11 Gene

Genomics for NEK11 Gene

Regulatory Elements for NEK11 Gene

Enhancers for NEK11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NEK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK11 Gene

Chromosome:
3
Start:
131,026,850 bp from pter
End:
131,350,465 bp from pter
Size:
323,616 bases
Orientation:
Plus strand

Genomic View for NEK11 Gene

Genes around NEK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK11 Gene

Proteins for NEK11 Gene

  • Protein details for NEK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG66-NEK11_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek11
    Protein Accession:
    Q8NG66
    Secondary Accessions:
    • A6NHD7
    • Q5JPC0
    • Q8NG65
    • Q8TBY1
    • Q9H5F4

    Protein attributes for NEK11 Gene

    Size:
    645 amino acids
    Molecular mass:
    74192 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with isoform 1 of NEK2.
    SequenceCaution:
    • Sequence=BAB15672.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEK11 Gene

Selected DME Specific Peptides for NEK11 Gene

Post-translational modifications for NEK11 Gene

  • Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NEK11 Gene

Gene Families for NEK11 Gene

Protein Domains for NEK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG66

UniProtKB/Swiss-Prot:

NEK11_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK11: view

Function for NEK11 Gene

Molecular function for NEK11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc.
UniProtKB/Swiss-Prot Function:
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.

Enzyme Numbers (IUBMB) for NEK11 Gene

Gene Ontology (GO) - Molecular Function for NEK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA 15161910
GO:0005515 protein binding IPI 15161910
GO:0005524 ATP binding IDA 15161910
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NEK11: view
genes like me logo Genes that share phenotypes with NEK11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NEK11

CRISPR Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK11 Gene

Localization for NEK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEK11 Gene

Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S-arrested cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK11 Gene COMPARTMENTS Subcellular localization image for NEK11 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 15161910
genes like me logo Genes that share ontologies with NEK11: view

Pathways & Interactions for NEK11 Gene

SuperPathways for NEK11 Gene

No Data Available

SIGNOR curated interactions for NEK11 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NEK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15161910
GO:0016572 histone phosphorylation IMP 12154088
GO:0031572 G2 DNA damage checkpoint IMP 19734889
GO:0031573 intra-S DNA damage checkpoint IDA 15161910
GO:0035556 intracellular signal transduction IDA 15161910
genes like me logo Genes that share ontologies with NEK11: view

No data available for Pathways by source for NEK11 Gene

Drugs & Compounds for NEK11 Gene

(5) Drugs for NEK11 Gene - From: DrugBank, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dabrafenib Approved Pharma Target, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 75
Tafinlar Approved May 2013 Pharma 0
Adenosine triphosphate Approved Nutra 0
Manganese Approved Nutra 33
Magnesium Nutra 0

(1) Additional Compounds for NEK11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NEK11: view

Transcripts for NEK11 Gene

Unigene Clusters for NEK11 Gene

NIMA-related kinase 11:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - -
SP2: -
SP3:

Relevant External Links for NEK11 Gene

GeneLoc Exon Structure for
NEK11
ECgene alternative splicing isoforms for
NEK11

Expression for NEK11 Gene

mRNA expression in normal human tissues for NEK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEK11 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK11 Gene



Protein tissue co-expression partners for NEK11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEK11 Gene:

NEK11

SOURCE GeneReport for Unigene cluster for NEK11 Gene:

Hs.657336

mRNA Expression by UniProt/SwissProt for NEK11 Gene:

Q8NG66-NEK11_HUMAN
Tissue specificity: Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
genes like me logo Genes that share expression patterns with NEK11: view

Primer Products

No data available for mRNA differential expression in normal tissues for NEK11 Gene

Orthologs for NEK11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEK11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NEK11 34
  • 84.84 (n)
  • 80.62 (a)
NEK11 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK11 34
  • 88.19 (n)
  • 85.13 (a)
NEK11 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek11 34
  • 80.83 (n)
  • 76.94 (a)
Nek11 16
Nek11 35
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NEK11 34
  • 99.5 (n)
  • 99.36 (a)
NEK11 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nek11 34
  • 79.59 (n)
  • 74.9 (a)
oppossum
(Monodelphis domestica)
Mammalia NEK11 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEK11 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK11 34
  • 71.7 (n)
  • 70.67 (a)
NEK11 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK11 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nek11 34
  • 65.53 (n)
  • 61.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883026 34
  • 59.69 (n)
  • 55.54 (a)
NEK11 35
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-1 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6732 35
  • 45 (a)
OneToOne
Species where no ortholog for NEK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEK11 Gene

ENSEMBL:
Gene Tree for NEK11 (if available)
TreeFam:
Gene Tree for NEK11 (if available)

Paralogs for NEK11 Gene

Paralogs for NEK11 Gene

genes like me logo Genes that share paralogs with NEK11: view

Variants for NEK11 Gene

Sequence variations from dbSNP and Humsavar for NEK11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs16836266 - 131,273,541(+) CAGTG(C/T)GATGG intron-variant, nc-transcript-variant, reference, missense
rs200709914 A colorectal adenocarcinoma sample 131,080,575(+) TATCA(C/T)GGAGT intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs55806123 - 131,109,834(+) GGAAT(A/G)TAAAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs55920129 - 131,133,947(+) AAAGT(C/T)GGACA nc-transcript-variant, reference, missense
rs35567155 - 131,152,527(+) ATGCC(A/G)TCATG intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NEK11 Gene

Variant ID Type Subtype PubMed ID
esv2667216 CNV deletion 23128226
esv2725916 CNV deletion 23290073
esv3414685 CNV insertion 20981092
esv3597778 CNV loss 21293372
esv3597780 CNV loss 21293372
esv3597781 CNV gain 21293372
esv3597782 CNV gain 21293372
nsv1010659 CNV loss 25217958
nsv1151674 CNV duplication 26484159
nsv4006 CNV insertion 18451855
nsv524200 CNV loss 19592680
nsv997295 CNV loss 25217958

Variation tolerance for NEK11 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.79; 91.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK11 Gene

Human Gene Mutation Database (HGMD)
NEK11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK11 Gene

Disorders for NEK11 Gene

Relevant External Links for NEK11

Genetic Association Database (GAD)
NEK11
Human Genome Epidemiology (HuGE) Navigator
NEK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK11

No disorders were found for NEK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK11 Gene

Publications for NEK11 Gene

  1. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. (PMID: 19734889) Melixetian M. … Helin K. (Nat. Cell Biol. 2009) 3 4 22 65
  2. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. (PMID: 12154088) Noguchi K. … Uehara Y. (J. Biol. Chem. 2002) 3 4 22 65
  3. NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. (PMID: 20090422) Soerensen C.S. … Helin K. (Cell Cycle 2010) 3 4 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 65

Products for NEK11 Gene

Sources for NEK11 Gene

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