Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEK10 Gene

Aliases for NEK10 Gene

  • NIMA Related Kinase 10 2 3 5
  • NIMA (Never In Mitosis Gene A)- Related Kinase 10 2
  • Never In Mitosis A-Related Kinase 10 4
  • NimA-Related Protein Kinase 10 4
  • EC 2.7.11.1 4

External Ids for NEK10 Gene

Previous GeneCards Identifiers for NEK10 Gene

  • GC00U991209

Summaries for NEK10 Gene

GeneCards Summary for NEK10 Gene

NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK9.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK10 Gene

Genomics for NEK10 Gene

Regulatory Elements for NEK10 Gene

Enhancers for NEK10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G027325 1.3 Ensembl ENCODE 22.4 +43.0 43040 2.8 ATF1 FOXA2 ARID4B SIN3A ZNF48 GLIS2 ZNF143 FOS YY2 NFYC NEK10 GC03P027342 RNU6-342P GC03M027265
GH03G027358 1.6 Ensembl ENCODE dbSUPER 12.5 +9.7 9704 3.3 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 ZNF143 FOS SP5 NEK10 SLC4A7 GC03M027342
GH03G027316 0.9 ENCODE 21.3 +52.2 52165 0.8 ELF3 TBP PKNOX1 FOXA2 ARID4B RAD21 THRB RARA CREM MIXL1 NEK10 RNU6-342P CMC1 GC03P027342 GC03M027265
GH03G027479 1.6 FANTOM5 Ensembl ENCODE 10 -113.0 -113003 6.4 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 ZNF207 FOS RNU1-96P NEK10 ZCWPW2 SLC4A7 RPS20P15
GH03G027531 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.4 -164.8 -164837 5.3 PKNOX1 FOXA2 SIN3A ETS1 ELK1 GATA2 FOS JUNB PPARG ZNF579 RNU1-96P NEK10 LOC105377005 GC03M027547 ENSG00000238912
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEK10 on UCSC Golden Path with GeneCards custom track

Promoters for NEK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149978 160 1000 ATF1 ARID4B SIN3A GLIS2 ZNF143 ZNF207 FOS YY2 MXD4 NFYC

Genomic Location for NEK10 Gene

Chromosome:
3
Start:
27,107,336 bp from pter
End:
27,369,460 bp from pter
Size:
262,125 bases
Orientation:
Minus strand

Genomic View for NEK10 Gene

Genes around NEK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK10 Gene

Proteins for NEK10 Gene

  • Protein details for NEK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWH5-NEK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek10
    Protein Accession:
    Q6ZWH5
    Secondary Accessions:
    • A8MWG1
    • B9ZVR0
    • Q45VJ4
    • Q6ZR11
    • Q7Z671
    • Q86XB1
    • Q96MB3

    Protein attributes for NEK10 Gene

    Size:
    1172 amino acids
    Molecular mass:
    133259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEK10 Gene

neXtProt entry for NEK10 Gene

Post-translational modifications for NEK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEK10 Gene

Domains & Families for NEK10 Gene

Gene Families for NEK10 Gene

Suggested Antigen Peptide Sequences for NEK10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWH5

UniProtKB/Swiss-Prot:

NEK10_HUMAN :
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK10: view

Function for NEK10 Gene

Molecular function for NEK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for NEK10 Gene

Gene Ontology (GO) - Molecular Function for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA,IEA 20956560
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NEK10: view
genes like me logo Genes that share phenotypes with NEK10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK10 Gene

Localization for NEK10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK10 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902911 protein kinase complex IDA 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NEK10 Gene

Pathways & Interactions for NEK10 Gene

SuperPathways for NEK10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 20956560
GO:0016310 phosphorylation IEA --
GO:0031954 positive regulation of protein autophosphorylation IDA 20956560
GO:0043406 positive regulation of MAP kinase activity IMP 20956560
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Pathways by source and SIGNOR curated interactions for NEK10 Gene

Drugs & Compounds for NEK10 Gene

(1) Drugs for NEK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with NEK10: view

Transcripts for NEK10 Gene

Unigene Clusters for NEK10 Gene

NIMA-related kinase 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: - -
SP3:

ExUns: 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for NEK10 Gene

GeneLoc Exon Structure for
NEK10
ECgene alternative splicing isoforms for
NEK10

Expression for NEK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEK10 Gene

mRNA differential expression in normal tissues according to GTEx for NEK10 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for NEK10 Gene

This gene is overexpressed in Liver, secretome (31.5), Peripheral blood mononuclear cells (22.1), and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK10 Gene



Protein tissue co-expression partners for NEK10 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEK10 Gene:

NEK10

SOURCE GeneReport for Unigene cluster for NEK10 Gene:

Hs.506115

Evidence on tissue expression from TISSUES for NEK10 Gene

  • Heart(4)
  • Liver(4)
  • Intestine(3.4)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NEK10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK10 Gene

Orthologs for NEK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK10 34 35
  • 99.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 11 (a)
OneToMany
-- 35
  • 2 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nek10 35
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK10 35
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK10 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK10 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK10 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK10 35
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NEK10 35
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-4 35
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 35
  • 14 (a)
OneToMany
Species where no ortholog for NEK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEK10 Gene

ENSEMBL:
Gene Tree for NEK10 (if available)
TreeFam:
Gene Tree for NEK10 (if available)

Paralogs for NEK10 Gene

Paralogs for NEK10 Gene

genes like me logo Genes that share paralogs with NEK10: view

Variants for NEK10 Gene

Sequence variations from dbSNP and Humsavar for NEK10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs201821707 An ovarian mucinous carcinoma sample 27,346,152(+) CACCC(A/C/G/T)CCCTG nc-transcript-variant, reference, missense
VAR_040931 A metastatic melanoma sample
rs1000001329 -- 27,260,943(+) GTTTA(A/C/G)TCTTG intron-variant
rs1000006501 -- 27,357,885(+) TGGGA(A/G)AGGAG intron-variant
rs1000009715 -- 27,285,138(+) GAGGG(C/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK10 Gene

Variant ID Type Subtype PubMed ID
dgv880e214 CNV gain 21293372
dgv881e214 CNV loss 21293372
esv3397214 CNV duplication 20981092
esv3595661 CNV gain 21293372
esv3595663 CNV loss 21293372
esv3595666 CNV gain 21293372
esv3595667 CNV gain 21293372
nsv3742 CNV insertion 18451855
nsv509818 OTHER sequence alteration 20534489

Variation tolerance for NEK10 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK10 Gene

Human Gene Mutation Database (HGMD)
NEK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK10 Gene

Disorders for NEK10 Gene

Relevant External Links for NEK10

Genetic Association Database (GAD)
NEK10
Human Genome Epidemiology (HuGE) Navigator
NEK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK10

No disorders were found for NEK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK10 Gene

Publications for NEK10 Gene

  1. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 46 64
  2. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PMID: 20145138) Odefrey F. … Southey M.C. (Cancer Res. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PMID: 19330027) Ahmed S. … Easton D.F. (Nat. Genet. 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NEK10 Gene

  • Addgene plasmids for NEK10

Sources for NEK10 Gene

Content
Loading form....