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Aliases for NEK10 Gene

Aliases for NEK10 Gene

  • NIMA-Related Kinase 10 2 3
  • NIMA (Never In Mitosis Gene A)- Related Kinase 10 2
  • Never In Mitosis A-Related Kinase 10 4
  • NimA-Related Protein Kinase 10 4
  • EC 2.7.11.1 4

External Ids for NEK10 Gene

Summaries for NEK10 Gene

GeneCards Summary for NEK10 Gene

NEK10 (NIMA-Related Kinase 10) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK10 Gene

Genomics for NEK10 Gene

Genomic Location for NEK10 Gene

Start:
27,080,151 bp from pter
End:
27,369,460 bp from pter
Size:
289,310 bases
Orientation:
Minus strand

Genomic View for NEK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK10 Gene

Regulatory Elements for NEK10 Gene

Proteins for NEK10 Gene

  • Protein details for NEK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWH5-NEK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek10
    Protein Accession:
    Q6ZWH5
    Secondary Accessions:
    • A8MWG1
    • B9ZVR0
    • Q45VJ4
    • Q6ZR11
    • Q7Z671
    • Q86XB1
    • Q96MB3

    Protein attributes for NEK10 Gene

    Size:
    1172 amino acids
    Molecular mass:
    133259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEK10 Gene

neXtProt entry for NEK10 Gene

Proteomics data for NEK10 Gene at MOPED

Post-translational modifications for NEK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEK10 Gene

Domains for NEK10 Gene

UniProtKB/Swiss-Prot:

NEK10_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q6ZWH5
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.:
    • Q6ZWH5
Similarity:
  • Contains 1 ARM repeat.:
    • Q6ZWH5
genes like me logo Genes that share domains with NEK10: view

Function for NEK10 Gene

Molecular function for NEK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for NEK10 Gene

Gene Ontology (GO) - Molecular Function for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004672 protein kinase activity IDA 20956560
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005488 binding --
genes like me logo Genes that share ontologies with NEK10: view

Phenotypes for NEK10 Gene

genes like me logo Genes that share phenotypes with NEK10: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NEK10 Gene

Localization for NEK10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK10 Gene COMPARTMENTS Subcellular localization image for NEK10 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902911 protein kinase complex IDA 20956560
genes like me logo Genes that share ontologies with NEK10: view

Pathways for NEK10 Gene

SuperPathways for NEK10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 20956560
GO:0031954 positive regulation of protein autophosphorylation IDA 20956560
GO:0043406 positive regulation of MAP kinase activity IMP 20956560
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20956560
GO:1902749 regulation of cell cycle G2/M phase transition IMP 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Pathways by source for NEK10 Gene

Compounds for NEK10 Gene

(1) HMDB Compounds for NEK10 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with NEK10: view

Transcripts for NEK10 Gene

Unigene Clusters for NEK10 Gene

NIMA-related kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: - -
SP3:

ExUns: 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for NEK10 Gene

GeneLoc Exon Structure for
NEK10
ECgene alternative splicing isoforms for
NEK10

Expression for NEK10 Gene

mRNA expression in normal human tissues for NEK10 Gene

mRNA differential expression in normal tissues according to GTEx for NEK10 Gene

This gene is overexpressed in Testis (10.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEK10 Gene

SOURCE GeneReport for Unigene cluster for NEK10 Gene Hs.506115

genes like me logo Genes that share expressions with NEK10: view

Orthologs for NEK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK10 36
  • 99.34 (n)
  • 98.88 (a)
NEK10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK10 37
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK10 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek10 16
Nek10 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK10 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 2 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
-- 37
  • 11 (a)
OneToMany
chicken
(Gallus gallus)
Aves NEK10 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK10 37
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NEK10 37
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-4 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 37
  • 14 (a)
OneToMany
Species with no ortholog for NEK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEK10 Gene

ENSEMBL:
Gene Tree for NEK10 (if available)
TreeFam:
Gene Tree for NEK10 (if available)

Paralogs for NEK10 Gene

Paralogs for NEK10 Gene

genes like me logo Genes that share paralogs with NEK10: view

Variants for NEK10 Gene

Sequence variations from dbSNP and Humsavar for NEK10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs472146 -- 27,295,888(+) ACAAT(C/T)TTAAA intron-variant
rs473618 -- 27,292,436(-) TTTAT(G/T)TGTTT intron-variant
rs479302 -- 27,321,542(+) GTGGC(A/G)CGTGC intron-variant
rs479404 -- 27,321,573(+) GAGGC(C/T)AAGGA intron-variant
rs479566 -- 27,285,508(+) TTATG(C/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEK10 Gene

Variant ID Type Subtype PubMed ID
nsv876644 CNV Loss 21882294
nsv509818 CNV Loss 20534489
nsv3742 CNV Insertion 18451855

Relevant External Links for NEK10 Gene

HapMap Linkage Disequilibrium report
NEK10
Human Gene Mutation Database (HGMD)
NEK10

Disorders for NEK10 Gene

Relevant External Links for NEK10

Genetic Association Database (GAD)
NEK10
Human Genome Epidemiology (HuGE) Navigator
NEK10
genes like me logo Genes that share disorders with NEK10: view

No data available for UniProtKB/Swiss-Prot for NEK10 Gene

Publications for NEK10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PMID: 19330027) Ahmed S. … Easton D.F. (Nat. Genet. 2009) 3 49
  3. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 49
  4. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PMID: 20145138) Odefrey F. … Southey M.C. (Cancer Res. 2010) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for NEK10 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NEK10
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NEK10
    • Block miRNA regulation of NEK10 using miScript Target Protectors

    Sources for NEK10 Gene

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