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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NEK10 Gene

protein-coding GIFtS: 48
GCID: GC03M027128

NIMA-related kinase 10

(Previous name: NIMA (never in mitosis gene a)- related kinase 10 )

Explore 2 diseases affiliated with
NEK10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NIMA-Related Kinase 10¹ ²		FLJ32685¹
NIMA (Never In Mitosis Gene A)- Related Kinase 10¹ ²		Serine/Threonine-Protein Kinase Nek10²
Never In Mitosis A-Related Kinase 10² ³		EC 2.7.11.1³
NimA-Related Protein Kinase 10² ³

External Ids:	HGNC: 18592¹	Entrez Gene: 152110²	Ensembl: ENSG00000163491⁷	UniProtKB: Q6ZWH5³

Export aliases for NEK10 gene to outside databases

Previous GC identifer: GC00U991209

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEK10 gene promoter:
Nkx3-1 HFH-3 RFX1 Pbx1a Nkx3-1 v1 C/EBPalpha Gfi-1 Nkx3-1 v2 FOXI1 HFH-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEK10 promoter sequence

Search SABiosciences Chromatin IP Primers for NEK10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1 Ensembl cytogenetic band: 3p24.1 HGNC cytogenetic band: 3p24.1

NEK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK10 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M027128: view genomic region (about GC identifiers)

Start:	27,151,576 bp from pter	End:	27,410,951 bp from pter
Size:	259,376 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEK10_HUMAN, Q6ZWH5 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase Nek10

Size: 1172 amino acids; 133259 Da

Cofactor: Magnesium (By similarity)

Secondary accessions: A8MWG1 B9ZVR0 Q45VJ4 Q6ZR11 Q7Z671 Q86XB1 Q96MB3

Alternative splicing: 7 isoforms: Q6ZWH5-1 Q6ZWH5-2 Q6ZWH5-3 Q6ZWH5-4 Q6ZWH5-5 Q6ZWH5-6 Q6ZWH5-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEK10: NX_Q6ZWH5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZWH5

NEK10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_955379.2

ENSEMBL proteins:

ENSP00000295720 ENSP00000373281 ENSP00000395849 ENSP00000343847 ENSP00000412651

ENSP00000392344 ENSP00000395338 ENSP00000373280 ENSP00000350059

Human Recombinant Protein Products for NEK10:

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	Uscn Proteins for NEK10

NEK10 Antibody Products:

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	Novus Biologicals NEK10 Antibodies
	Abcam antibodies for NEK10
	Uscn Antibodies for NEK10
	Search ThermoFisher Antibodies for NEK10

Assay Products for NEK10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEK10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEK10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEK10 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR017441 Protein_kinase_ATP_BS

IPR011989 ARM-like

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q6ZWH5

ProtoNet protein and cluster: Q6ZWH5

UniProtKB/Swiss-Prot: NEK10_HUMAN, Q6ZWH5

Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily

Similarity: Contains 1 ARM repeat

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NEK10_HUMAN, Q6ZWH5

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--

NEK10 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for NEK10:

Decreased focal adhesion (FA)

Decreased substrate adherent c

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NEK10

miRNA Products:		OriGene 3'-UTR Clone: NEK10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEK10
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NEK10
		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): NEK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEK10 (see all 4) OriGene shRNA RFP: NEK10 OriGene siRNA: NEK10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK10
		Sirion Biotech Custom design and validation of potent shRNA sequences against NEK10

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NEK10
			Sirion Biotech Customized adenovirus for overexpression of NEK10 Sirion Biotech Customized adenovirus for potent knockdown of NEK10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEK10 (NM_199347)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NEK10
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		Sirion Biotech Customized stable knockdown cell line services for NEK10 Sirion Biotech Customized inducible knockdown cell line services for NEK10 Sirion Biotech Customized stable overexpressing cell line services for NEK10 Sirion Biotech Customized inducible overexpressing cell line services for NEK10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NEK10

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for NEK10 (Q6ZWH5³ ENSP00000343847⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP2K1	Q02750³	I2D: score=1
RAF1	P04049³	I2D: score=1
SUMO1	ENSP00000376076⁴	STRING: ENSP00000376076
SIRT3	ENSP00000372191⁴	STRING: ENSP00000372191
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NEK10

1 HMDB Compound for NEK10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about NEK10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NEK10 gene (3 alternative transcripts):

NM_001031741.2 NM_152534.3 NM_199347.2

Unigene Clusters for NEK10:

NIMA-related kinase 10

Hs.506115 [show with all ESTs], Hs.743887 [show with all ESTs]

Unigene Representative Sequences: NM_199347, DQ104438

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295720(uc010hfk.3) ENST00000383771(uc010hfj.3) ENST00000429845

ENST00000498182 ENST00000574215(uc003cds.1) ENST00000460447 ENST00000341435(uc003cdt.2)

ENST00000435584 ENST00000424275 ENST00000474938 ENST00000491627(uc021wuk.1)

ENST00000435750 ENST00000383770 ENST00000357467

miRNA Products:		OriGene 3'-UTR Clone: NEK10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEK10
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NEK10
		SwitchGear 3'UTR luciferase reporter plasmids (see all 2): NEK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEK10 (see all 4) OriGene shRNA RFP: NEK10 OriGene siRNA: NEK10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK10
		Sirion Biotech Custom design and validation of potent shRNA sequences against NEK10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NEK10 (NM_199347)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEK10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat NEK10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK10

Additional cDNA sequence: DQ104438.1

9 DOTS entries:

DT.95328838 DT.100737290 DT.101978734 DT.100012113 DT.40276230 DT.120879475 DT.120879502 DT.97801984

DT.40250201

24/30 AceView cDNA sequences (see all 30):

AA954906 AA430250 T08896 AK123061 CD106458 AI652681 AK098832 BX537852

NM_152534 AK057247 AI149647 BC045758 BM976126 BM976173 AK128585 AI611061

AI962584 AA889152 AA843473 BI462787 BG717420 AA429606 AW372558 BU568655

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NEK10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:
SP2:																									-		-
SP3:

ExUns:	27	^	28
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for NEK10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NEK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCCTGCAG

About this image

NEK10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NEK10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEK10

SOURCE GeneReport for Unigene clusters: Hs.506115 Hs.743887

SABiosciences Custom PCR Arrays for NEK10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEK10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat NEK10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NEK10 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NEK10⁶	Uncharacterized protein	81(a)	1 ↔ 1	2(38402083-38429197)
lizard (Anolis carolinensis)	Reptilia	NEK10⁶	--	27(a)	1 ↔ 1	1(196474237-196503267)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX722245.1²	--	76.07(n)		BX722245.1
zebrafish (Danio rerio)	Actinopterygii	CU855686.1⁶	--	37(a)	1 ↔ 1	16(53639994-53678806)
worm (Caenorhabditis elegans)	Secernentea	nekl-4⁶	Serine/threonine-protein kinase D1044.8	20(a)	1 ↔ 1	III(5512887-5517483)

ENSEMBL Gene Tree for NEK10 (if available)
TreeFam Gene Tree for NEK10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NEK10 gene

NEK4² NEK6² NEK1² NEK11² NEK3² NEK7² NEK5² NEK2²

NEK8² NEK9²

18/25 SIMAP similar genes for NEK10 using alignment to 5 protein entries: NEK10_HUMAN (see all proteins) (see all similar genes):

MARK4 NEK5 NEK6 NEK7 DKFZp564L2416 NEK8

NUAK1 BRSK2 NEK11 RPS6KA2 RPS6KA3 DAPK1

PRKY CAMK1 NEK3 RPS6KA4 AURKB MST094

NEK10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116629023^1,2	F	--	27256640(+)	`CACCAT/GCAAAA`	1	--	int¹		1		NA	120
rs3099203^1,2	H	--	27256694(+)	`TCTTTC/G/TTGCAC`	1	--	int¹ trp³		4		NS EA	420
rs181163511^1,2		--	27256966(+)	`ATAAGA/GATTGC`	1	--	int¹		0	--	--	--	--
rs35896441^1,2	C,F	--	27257002(+)	`AAGGCA/GTAGAA`	1	--	int¹		6		NA CSA WA EA	363
rs7652855^1,2	C,F,A,H	--	27257026(+)	`ACTCAA/GATGAG`	1	--	int¹		25		NS EA NA WA CSA	2244
rs184397821^1,2		--	27257028(+)	`TCAGAA/TGAGTT`	1	--	int¹		0	--	--	--	--
rs149825031^1,2		--	27257123(+)	`TTTTGA/TTTATC`	1	--	ut3¹		0	--	--	--	--
rs142050316^1,2		--	27257152(+)	`AATCCA/GTTCTT`	1	--	ut3¹		0	--	--	--	--
rs144218798^1,2		--	27257314(+)	`GGAGCC/TAGCAC`	1	--	ut3¹		0	--	--	--	--
rs3112807^1,2	C	--	27257345(+)	`GAGCAC/GGAGAG`	2	P R	mis¹ ese³		0	--	--	--	--

HapMap Linkage Disequilibrium report for NEK10 (27151576 - 27401576 bp, first 250kb of NEK10)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEK10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEK10

DNA2.0 Custom Variant and Variant Library Synthesis for NEK10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEK10 for disorders About GeneDecksing

2 diseases for NEK10: About MalaCards

breast cancer susceptibility breast cancer

Human Genome Epidemiology (HuGE) Navigator: NEK10 (4 documents)

Export disorders for NEK10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NEK10 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NEK10)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The mouse kinome: discovery and comparative genomics of all mouse protein kinases. (PubMed id 15289607)^{1, 3} Caenepeel S....Manning G. (2004)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Nek10 mediates G2/M cell cycle arrest and MEK autoact ivation in response to UV irradiation. (PubMed id 20956560)¹ Moniz L.S. and Stambolic V. (2011)
Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)¹ Grant M.M. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)¹ Bhatti P....Sigurdson A.J. (2010)
Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)¹ Odefrey F....Southey M.C. (2010)
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PubMed id 19330027)¹ Ahmed S....Easton D.F. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 152110	HGNC: 18592	AceView: FLJ32685	Ensembl:ENSG00000163491	euGenes: HUgn152110
ECgene: NEK10	H-InvDB: NEK10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NEK10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NEK10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NEK10 gene:
Search GeneIP for patents involving NEK10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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NEK10 Gene

NIMA-related kinase 10

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NEK10 Gene

NIMA-related kinase 10

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for NEK10 gene

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Intellectual Property
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