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Aliases for NEK10 Gene

Aliases for NEK10 Gene

  • NIMA Related Kinase 10 2 3
  • NIMA (Never In Mitosis Gene A)- Related Kinase 10 2
  • Never In Mitosis A-Related Kinase 10 4
  • NimA-Related Protein Kinase 10 4
  • NIMA-Related Kinase 10 5
  • EC 2.7.11.1 4

External Ids for NEK10 Gene

Previous GeneCards Identifiers for NEK10 Gene

  • GC00U991209

Summaries for NEK10 Gene

GeneCards Summary for NEK10 Gene

NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NEK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK10 Gene

Genomics for NEK10 Gene

Regulatory Elements for NEK10 Gene

Enhancers for NEK10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEK10 on UCSC Golden Path with GeneCards custom track

Promoters for NEK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEK10 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEK10 Gene

Chromosome:
3
Start:
27,107,336 bp from pter
End:
27,369,460 bp from pter
Size:
262,125 bases
Orientation:
Minus strand

Genomic View for NEK10 Gene

Genes around NEK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK10 Gene

Proteins for NEK10 Gene

  • Protein details for NEK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWH5-NEK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek10
    Protein Accession:
    Q6ZWH5
    Secondary Accessions:
    • A8MWG1
    • B9ZVR0
    • Q45VJ4
    • Q6ZR11
    • Q7Z671
    • Q86XB1
    • Q96MB3

    Protein attributes for NEK10 Gene

    Size:
    1172 amino acids
    Molecular mass:
    133259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEK10 Gene

neXtProt entry for NEK10 Gene

Proteomics data for NEK10 Gene at MOPED

Post-translational modifications for NEK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEK10 Gene

Domains & Families for NEK10 Gene

Gene Families for NEK10 Gene

Suggested Antigen Peptide Sequences for NEK10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWH5

UniProtKB/Swiss-Prot:

NEK10_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
  • Contains 1 ARM repeat.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Similarity:
  • Contains 1 ARM repeat.
genes like me logo Genes that share domains with NEK10: view

Function for NEK10 Gene

Molecular function for NEK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for NEK10 Gene

Gene Ontology (GO) - Molecular Function for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NEK10: view
genes like me logo Genes that share phenotypes with NEK10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK10 Gene

Localization for NEK10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEK10 Gene COMPARTMENTS Subcellular localization image for NEK10 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with NEK10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NEK10 Gene

Pathways & Interactions for NEK10 Gene

SuperPathways for NEK10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 20956560
GO:0007017 microtubule-based process IBA --
GO:0031954 positive regulation of protein autophosphorylation IDA 20956560
GO:0043406 positive regulation of MAP kinase activity IMP 20956560
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Pathways by source and SIGNOR curated interactions for NEK10 Gene

Drugs & Compounds for NEK10 Gene

(1) Drugs for NEK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with NEK10: view

Transcripts for NEK10 Gene

Unigene Clusters for NEK10 Gene

NIMA-related kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: - -
SP3:

ExUns: 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for NEK10 Gene

GeneLoc Exon Structure for
NEK10
ECgene alternative splicing isoforms for
NEK10

Expression for NEK10 Gene

mRNA expression in normal human tissues for NEK10 Gene

mRNA differential expression in normal tissues according to GTEx for NEK10 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for NEK10 Gene

This gene is overexpressed in Liver, secretome (31.5), Peripheral blood mononuclear cells (22.1), and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK10 Gene



SOURCE GeneReport for Unigene cluster for NEK10 Gene Hs.506115

genes like me logo Genes that share expression patterns with NEK10: view

Protein tissue co-expression partners for NEK10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NEK10 Gene

Orthologs for NEK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK10 35
  • 99.34 (n)
  • 98.88 (a)
NEK10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK10 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEK10 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK10 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek10 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 11 (a)
OneToMany
chicken
(Gallus gallus)
Aves NEK10 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK10 36
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NEK10 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-4 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 36
  • 14 (a)
OneToMany
Species with no ortholog for NEK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEK10 Gene

ENSEMBL:
Gene Tree for NEK10 (if available)
TreeFam:
Gene Tree for NEK10 (if available)

Paralogs for NEK10 Gene

Paralogs for NEK10 Gene

genes like me logo Genes that share paralogs with NEK10: view

Variants for NEK10 Gene

Sequence variations from dbSNP and Humsavar for NEK10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs56125830 - 27,346,199(+) CTATC(G/T)AAGTT nc-transcript-variant, reference, missense
VAR_040929 An ovarian mucinous carcinoma sample
rs55958314 - 27,346,150(+) TCCAC(C/T)CGCCC nc-transcript-variant, reference, missense
VAR_040931 A metastatic melanoma sample
rs10510592 - 27,291,329(-) TCCTT(C/T)GAAAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NEK10 Gene

Variant ID Type Subtype PubMed ID
nsv876644 CNV Loss 21882294
nsv509818 CNV Loss 20534489
nsv3742 CNV Insertion 18451855

Variation tolerance for NEK10 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEK10 Gene

Human Gene Mutation Database (HGMD)
NEK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK10 Gene

Disorders for NEK10 Gene

Relevant External Links for NEK10

Genetic Association Database (GAD)
NEK10
Human Genome Epidemiology (HuGE) Navigator
NEK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEK10

No disorders were found for NEK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK10 Gene

Publications for NEK10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. (PMID: 24493630) Ahsan H. … Whittemore A.S. (Cancer Epidemiol. Biomarkers Prev. 2014) 3
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  5. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. (PMID: 20956560) Moniz L.S. … Stambolic V. (Mol. Cell. Biol. 2011) 3

Products for NEK10 Gene

Sources for NEK10 Gene

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