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Aliases for NEK10 Gene

Aliases for NEK10 Gene

  • NIMA Related Kinase 10 2 3 5
  • NIMA (Never In Mitosis Gene A)- Related Kinase 10 2
  • Never In Mitosis A-Related Kinase 10 4
  • NimA-Related Protein Kinase 10 4
  • EC 2.7.11.1 4

External Ids for NEK10 Gene

Previous GeneCards Identifiers for NEK10 Gene

  • GC00U991209

Summaries for NEK10 Gene

GeneCards Summary for NEK10 Gene

NEK10 (NIMA Related Kinase 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AURKA.

Additional gene information for NEK10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEK10 Gene

Genomics for NEK10 Gene

GeneHancer (GH) Regulatory Elements for NEK10 Gene

Promoters and enhancers for NEK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I027368 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.1 106 1.1 ATF1 ARID4B NEUROD1 SIN3A IRF4 GLIS2 ZNF207 ZNF143 FOS YY2 NEK10 SLC4A7 GC03M027342 GC03P027342
GH03I027216 Promoter 0.7 EPDnew 550.1 +152.9 152947 0.1 USF1 USF2 LOC105377004 MINOS1P3 GC03M027214 NEK10
GH03I027479 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10 -113.0 -113003 6.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 GLIS2 SLC4A7 RNU1-96P NEK10 ZCWPW2 RPS20P15
GH03I027325 Enhancer 0.9 Ensembl ENCODE 22.4 +43.0 43039 2.8 CTCF MAX ZNF644 RARA ZNF316 GATA3 FOS HOMEZ MAFK CEBPB NEK10 GC03P027342 RNU6-342P GC03M027265
GH03I027316 Enhancer 0.9 ENCODE 21.3 +52.2 52165 0.8 ELF3 FOXA2 ARID4B RAD21 THRB RARA CREM THAP11 MIXL1 HMG20B NEK10 RNU6-342P CMC1 GC03P027342 GC03M027265
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEK10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NEK10 gene promoter:

Genomic Locations for NEK10 Gene

Genomic Locations for NEK10 Gene
chr3:27,107,336-27,369,460
(GRCh38/hg38)
Size:
262,125 bases
Orientation:
Minus strand
chr3:27,151,576-27,410,951
(GRCh37/hg19)

Genomic View for NEK10 Gene

Genes around NEK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEK10 Gene

Proteins for NEK10 Gene

  • Protein details for NEK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWH5-NEK10_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Nek10
    Protein Accession:
    Q6ZWH5
    Secondary Accessions:
    • A8MWG1
    • B9ZVR0
    • Q45VJ4
    • Q6ZR11
    • Q7Z671
    • Q86XB1
    • Q96MB3

    Protein attributes for NEK10 Gene

    Size:
    1172 amino acids
    Molecular mass:
    133259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NEK10 Gene

neXtProt entry for NEK10 Gene

Post-translational modifications for NEK10 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NEK10 Gene

Domains & Families for NEK10 Gene

Gene Families for NEK10 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NEK10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZWH5

UniProtKB/Swiss-Prot:

NEK10_HUMAN :
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Family:
  • Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
genes like me logo Genes that share domains with NEK10: view

Function for NEK10 Gene

Molecular function for NEK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for NEK10 Gene

Phenotypes From GWAS Catalog for NEK10 Gene

Gene Ontology (GO) - Molecular Function for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 20956560
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NEK10: view
genes like me logo Genes that share phenotypes with NEK10: view

Clone Products

  • Addgene plasmids for NEK10

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEK10 Gene

Localization for NEK10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEK10 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902911 protein kinase complex IDA 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NEK10 Gene

Pathways & Interactions for NEK10 Gene

SuperPathways for NEK10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NEK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 20956560
GO:0016310 phosphorylation IEA --
GO:0031954 positive regulation of protein autophosphorylation IDA 20956560
GO:0043406 positive regulation of MAP kinase activity IMP 20956560
GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20956560
genes like me logo Genes that share ontologies with NEK10: view

No data available for Pathways by source and SIGNOR curated interactions for NEK10 Gene

Drugs & Compounds for NEK10 Gene

(1) Drugs for NEK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with NEK10: view

Transcripts for NEK10 Gene

Unigene Clusters for NEK10 Gene

NIMA-related kinase 10:
Representative Sequences:

Clone Products

  • Addgene plasmids for NEK10

Alternative Splicing Database (ASD) splice patterns (SP) for NEK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2: - -
SP3:

ExUns: 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for NEK10 Gene

GeneLoc Exon Structure for
NEK10
ECgene alternative splicing isoforms for
NEK10

Expression for NEK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEK10 Gene

mRNA differential expression in normal tissues according to GTEx for NEK10 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for NEK10 Gene

This gene is overexpressed in Liver, secretome (31.5), Peripheral blood mononuclear cells (22.1), and Tlymphocyte (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEK10 Gene



Protein tissue co-expression partners for NEK10 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEK10 Gene:

NEK10

SOURCE GeneReport for Unigene cluster for NEK10 Gene:

Hs.506115

Evidence on tissue expression from TISSUES for NEK10 Gene

  • Heart(4)
  • Liver(4)
  • Intestine(3.4)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NEK10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEK10 Gene

Orthologs for NEK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEK10 33 34
  • 99.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 11 (a)
OneToMany
-- 34
  • 2 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NEK10 34
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nek10 34
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEK10 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEK10 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEK10 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEK10 34
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NEK10 34
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nekl-4 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN3 34
  • 14 (a)
OneToMany
Species where no ortholog for NEK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NEK10 Gene

ENSEMBL:
Gene Tree for NEK10 (if available)
TreeFam:
Gene Tree for NEK10 (if available)

Paralogs for NEK10 Gene

Paralogs for NEK10 Gene

genes like me logo Genes that share paralogs with NEK10: view

Variants for NEK10 Gene

Sequence variations from dbSNP and Humsavar for NEK10 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs201821707 An ovarian mucinous carcinoma sample 27,346,152(-) G/A/C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
VAR_040931 A metastatic melanoma sample p.Glu379Lys
rs1000001329 -- 27,260,943(-) G/A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000006501 -- 27,357,885(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000009715 -- 27,285,138(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NEK10 Gene

Variant ID Type Subtype PubMed ID
dgv880e214 CNV gain 21293372
dgv881e214 CNV loss 21293372
esv3397214 CNV duplication 20981092
esv3595661 CNV gain 21293372
esv3595663 CNV loss 21293372
esv3595666 CNV gain 21293372
esv3595667 CNV gain 21293372
nsv3742 CNV insertion 18451855
nsv509818 OTHER sequence alteration 20534489

Variation tolerance for NEK10 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.01; 90.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEK10 Gene

Human Gene Mutation Database (HGMD)
NEK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEK10 Gene

Disorders for NEK10 Gene

Additional Disease Information for NEK10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NEK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEK10 Gene

Publications for NEK10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PMID: 20145138) Odefrey F … Australian Twins and Sisters Mammographic Density Study (Cancer research 2010) 3 44 58
  3. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P … Sigurdson AJ (Radiation research 2010) 3 44 58
  4. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PMID: 19330027) Ahmed S … Easton DF (Nature genetics 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for NEK10 Gene

  • Addgene plasmids for NEK10

Sources for NEK10 Gene

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