NEK1 Gene
protein-coding GIFtS: 56
GCID: GC04M170314
|
|
NIMA-related kinase 1(Previous name: NIMA (never in mitosis gene a)-related kinase 1 )
| |
Aliases
for NEK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NIMA-Related Kinase 11 2 | | EC 2.7.11.13 8 | | NY-REN-551 2 | | SRPS22 5 | | NIMA (Never In Mitosis Gene A)-Related Kinase 11 2 | | SRPS2A2 | | KIAA19011 3 | | Protein-Serine/Threonine Kinase2 | | Never In Mitosis A-Related Kinase 12 3 | | Serine/Threonine-Protein Kinase Nek12 | | NimA-Related Protein Kinase 12 3 | | EC 2.7.118 | | Renal Carcinoma Antigen NY-REN-552 3 | | |
Export aliases for NEK1 gene to outside databasesPrevious GC identifers: GC04M171085 GC04M170736 GC04M170898 GC04M171010 GC04M170689 GC04M170551 GC04M166069 |
Summaries
for NEK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEK1:
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein isfound in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in thisgene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have beenfound for this gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6Function: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated inthe control of meiosis (By similarity). Involved in cilium assembly
Gene Wiki entry for NEK1
|
Genomic Views
for NEK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEK1 gene promoter:
AhR Sox5 FOXC1 AML1a FOXD3 XBP-1 POU3F2 ATF6 C/EBPalpha Gfi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q33 Ensembl cytogenetic band: 4q33 HGNC cytogenetic band: 4q32.3NEK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M170314: view genomic region
(about GC identifiers)
Start:
|
170,314,426 bp from pter |
End:
|
170,533,780 bp from pter |
Size:
|
219,355 bases |
Orientation:
|
minus strand |
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Proteins
for NEK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase Nek1 Size: 1258 amino acids; 142828 Da
Cofactor: Magnesium
Subunit: Binds to SPERT (By similarity)
Subcellular location: Nucleus (Probable). Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Associated with thepericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity)
Sequence caution: Sequence=AAH15147.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAB15207.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55209.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB67794.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for NEK1:4APC (3D)
4B9D (3D)
Secondary accessions: Q05DG5 Q14CB7 Q5H9T1 Q6PIB8 Q96SS2 Q9H6P7 Q9Y594Alternative splicing: 5 isoforms: Q96PY6-1 Q96PY6-2 Q96PY6-3 Q96PY6-4 Q96PY6-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NEK1: NX_Q96PY6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PY6
2 DME Specific Peptides for NEK1 (Q96PY6)
NEK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001186326.1 NP_001186327.1 NP_001186328.1 NP_001186329.1 NP_036356.1
ENSEMBL proteins: ENSP00000408020 ENSP00000423332 ENSP00000427653 ENSP00000424757 ENSP00000424938 ENSP00000421525 ENSP00000424152
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
NEK1 for ontologies About GeneDecksing
NEK1 Antibody Products:
Assay Products for NEK1: |
Protein
Domains /
Families
for NEK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEK1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PY6ProtoNet protein and cluster: Q96PY6 UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamilySimilarity: Contains 1 protein kinase domain |
Function
for NEK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6Function: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated inthe control of meiosis (By similarity). Involved in cilium assemblyCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): NEK1 (NM_012224) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
NEK1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for NEK1:
Animal Models:
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nek1):
NEK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NEK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/19 Interacting proteins for NEK1 (Q96PY61, 3 ENSP000004080204) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
NEK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NEK1 for compounds About GeneDecksing
 Browse Tocris compounds for NEK1
3 HMDB Compounds for NEK1 About this table
2 Novoseek chemical compound relationships for NEK1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NEK1
|
Transcripts
for NEK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NEK1 gene (5 alternative transcripts): NM_001199397.1 NM_001199398.1 NM_001199399.1 NM_001199400.1 NM_012224.2 Unigene Cluster for NEK1: NIMA-related kinase 1 Hs.481181 [show with all ESTs]Unigene Representative Sequence: NM_0011993978 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439128(uc003isd.2 uc003isb.2 uc003isc.2) ENST00000511633(uc003ise.2 uc003isf.2)
ENST00000510533 ENST00000507142 ENST00000512193 ENST00000509912(uc003isg.1)
ENST00000505119 ENST00000510108
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): NEK1 (NM_012224) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK1 |
Additional cDNA sequence: AB067488.1 AF155113.1 AK024912.1 AK025658.1 AK027580.1 AL050385.1 BC015147.1 BC037790.2 BC068201.1 BC114491.1 CR933642.1 CR936672.1 Z25431.1 11 DOTS entries: DT.95267587 DT.91764501 DT.99990573 DT.412666 DT.100779770 DT.100841299 DT.97785337 DT.97770878 DT.95267585 DT.99966977 DT.95360858 24/124 AceView cDNA sequences (see all 124): AI816354 AI351373 BF431207 AA496964 AK024912 BQ889596 AW628079 AK025658 AA907081 AA463691 AI469371 AI588955 NM_012224 AI984346 AA421774 AW021316 AA253092 AA732495 AW300883 AB067488 AI927097 AA765482 N90356 BE881153
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NEK1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NEK1
|
Expression
for NEK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NEK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGCCAGA
About this image
See NEK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEK1
SOURCE GeneReport for Unigene cluster: Hs.481181
UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6Tissue specificity: High fetal expression in the brain and kidney
SABiosciences Custom PCR Arrays for NEK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK1 |
Orthologs
for NEK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NEK1 gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nek11 , 5 |
NIMA (never in mitosis gene a)-related expressed kinase more1, 5 |
85.81(n)1
82.88(a)1 |
|
8 (30.91 cM)5
180041 NM_175089.31 NP_780298.21
609931955 |
chicken
(Gallus gallus) |
Aves |
NEK11 |
NIMA (never in mitosis gene a)-related kinase 1 |
73.92(n)
70.57(a) |
|
422433 XM_420401.3 XP_420401.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NEK16 |
-- |
65(a) |
1 ↔ 1 |
GL343216.1(677769-723938) |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb55c032 |
Danio rerio mRNA similar to RNA binding motif protein more |
72.61(n) |
|
BC047836.1 |
ENSEMBL Gene Tree for NEK1 (if available)
TreeFam Gene Tree for NEK1 (if available) |
Paralogs
for NEK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NEK1 gene
- NEK42 NEK62 NEK112 NEK32 NEK72 NEK52 NEK22 NEK82
- NEK102 NEK92
18/30 SIMAP similar genes for NEK1 using alignment to 4 protein entries: NEK1_HUMAN (see all proteins)
(see all similar genes):DKFZp564L2416 DKFZp434B079 NEK3 RPS6KA3 CAMK2B NEK6
NEK7 NEK4 KIN27 STK11 MARK4 CDK4
NEK5 PRKACA PRKACB RPS6KA2 PAK4 CCRK
NEK1 for paralogs About GeneDecksing
|
Genomic Variants
for NEK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NEK1
2 CNVs: 92539 98957
Human Gene Mutation Database (HGMD): NEK1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEK1 |
|
Disorders
/ Diseases
for NEK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEK1 for disorders About GeneDecksing
OMIM gene information: 604588
OMIM disorders: 253520
UniProtKB/Swiss-Prot: NEK1_HUMAN, Q96PY6
Defects in NEK1 are the cause of short rib-polydactyly syndrome type 2 (SRPS2) [MIM:263520]. A lethal skeletaldysplasia characterized by markedly short ribs, short limbs, polydactyly, and multiple anomalies including a narrowthorax with hypoplastic lungs, extreme polysyndactyly, dysproportionate dwarfism, median cleft lip and palate, aventriculoseptal defect and cystic kidneys. The radiographic hallmarks include shortened and horizontal ribs, squaredscapulae and elevated clavicles with lateral kinking, normal spine and pelvis configuration, and shortening of thebones of all four extremities, with extreme reduction of tibial bone length
16  diseases for NEK1: About MalaCardsshort rib-polydactyly syndorme, type ii polycystic kidney disease short rib-polydactyly syndrome type 2 ellis-van creveld syndrome
kidney disease renal carcinoma polydactyly carcinoma
frontotemporal dementia sensenbrenner syndrome cystic kidney renal cell carcinoma
dwarfism dementia neuronitis malaria
4 diseases from the University of Copenhagen DISEASES database for NEK1:Polycystic kidney disease Sensenbrenner syndrome Polydactyly Asphyxiating thoracic dystrophy Human Genome Epidemiology (HuGE) Navigator: NEK1 (1 document)
Export disorders for NEK1 gene to outside databases
|
Publications
for NEK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NEK1 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with NEK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NEK1 mutations cause short-rib polydactyly syndrome t ype majewski. (PubMed id 21211617)1, 2 Thiel C....Rauch A. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T....Ohara O. (2001)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
- Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)1, 3 Schultz S.J. and Nigg E.A. (1993)
- A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. (PubMed id 1382974)1, 3 Letwin K....Pawson T. (1992)
- NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. (PubMed id 15604234)1, 9 Polci R....Chen Y. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- NEK1 and DYNC2H1 are both involved in short rib polyda ctyly Majewski type but not in Beemer Langer cases. (PubMed id 22499340)1 El Hokayem J....Cormier-Daire V. (2012)
- Short rib-polydactyly syndrome type II (Majewski): pre natal diagnosis, perinatal imaging findings and molecular analysis of the NEK1 g ene. (PubMed id 22482978)1 Chen C.P....Wang W. (2012)
|
External Searches for NEK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEK1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NEK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NEK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NEK1 gene:
Search GeneIP for patents involving NEK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NEK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NEK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEK1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for NEK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NEK1 | | OriGene Custom Protein Services for NEK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEK1 |
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| | | | Search Tocris compounds for NEK1 |
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 | | | NEK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEK1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NEK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEK1 |
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