Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEIL3 Gene

protein-coding   GIFtS: 52
GCID: GC04P178230

nei endonuclease VIII-like 3 (E. coli)
 Explore 4 diseases affiliated with
NEIL3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NEIL3    

Aliases
for NEIL3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nei Endonuclease VIII-Like 3 (E. Coli)1 2     FLJ108581
FPG21 2     FGP22
HFPG21     NEI32
HNEI31     DNA Glycosylase HFPG22
Endonuclease VIII-Like 32 3     Endonuclease 8-Like 32
Nei-Like Protein 32 3     EC 3.2.2.-3
DNA Glycosylase FPG22 3     EC 4.2.99.183
DNA Glycosylase/AP Lyase Neil32 3     

External Ids:    HGNC: 245731   Entrez Gene: 552472   Ensembl: ENSG000001096747   OMIM: 6089345   UniProtKB: Q8TAT53   

Export aliases for NEIL3 gene to outside databases

Previous GC identifers: GC04P178607 GC04P178468 GC04P173981


Summaries
for NEIL3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NEIL3:
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate
the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA
strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
Function: Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA
glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site
residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase
and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially
single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad
recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No
activity on 8-oxoG detected




Genomic Views
for NEIL3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEIL3 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   HNF-3beta   Evi-1   GATA-1   IRF-2   Nkx6-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEIL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEIL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEIL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.3   Ensembl cytogenetic band:  4q34.3   HGNC cytogenetic band: 4q34

NEIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEIL3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P178230:  view genomic region     (about GC identifiers)

Start:
 178,230,990 bp from pter      End:
 178,284,097 bp from pter
Size:
 53,108 bases      Orientation:
 plus strand

Proteins
for NEIL3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5 (See protein sequence)
Recommended Name: Endonuclease 8-like 3  
Size: 605 amino acids; 67769 Da
Subcellular location: Nucleus
Secondary accessions: Q2PPJ3 Q8NG51 Q9NV95

Explore the universe of human proteins at neXtProt for NEIL3: NX_Q8TAT5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TAT5

    • NEIL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060718.2  
    ENSEMBL proteins: 
     ENSP00000264596   ENSP00000424735  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NEIL3
    OriGene Custom Protein Services for NEIL3 
    GenScript Custom Purified and Recombinant Proteins Services for NEIL3
    Novus Biologicals NEIL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEIL3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12433996


    NEIL3 for ontologies           About GeneDecksing



    NEIL3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NEIL3 
    GenScript Custom Superior Antibodies Services for NEIL3
    Novus Biologicals NEIL3 Antibodies
    Search for Antibodies for NEIL3 at Abcam  
    Uscn Antibodies for NEIL3
    ThermoFisher Antibodies for NEIL3

    Assay Products for NEIL3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEIL3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEIL3

    Protein Domains /
    Families
    for NEIL3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NEIL3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR015887 DNA_glyclase_Znf_dom_DNA_BS
     IPR010979 Ribosomal_S13-like_H2TH
     IPR012319 DNA_glycosylase/AP_lyase_cat
     IPR010666 Znf_GRF
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q8TAT5

    ProtoNet protein and cluster: Q8TAT5

    1 Blocks protein family: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
    Similarity: Belongs to the FPG family
    Similarity: Contains 1 FPG-type zinc finger
    Similarity: Contains 1 RanBP2-type zinc finger


    Function
    for NEIL3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
    Function: Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA
    glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site
    residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase
    and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially
    single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad
    recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No
    activity on 8-oxoG detected
    Catalytic activity: Removes damaged bases from DNA, leaving an abasic site
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

    Enzyme Numbers (IUBMB): EC 4.2.99.181 EC 3.2.2.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NEIL3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEIL3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NEIL3:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: NEIL3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEIL3 (see all 4)
    OriGene shRNA RFP: NEIL3
    OriGene siRNA: NEIL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEIL3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NEIL3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEIL3 (NM_018248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NEIL3
    Search LifeMap BioReagents cell lines for NEIL3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL3

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000405bubble DNA binding ISS--
    GO:0003684damaged DNA binding IEA--
    GO:0003690double-stranded DNA binding ISS--
    GO:0003697single-stranded DNA binding IDA19170771
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IDA19170771


    NEIL3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NEIL3: Neil3tm1Yun Neil3tm1Bjor
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Neil3):
     cellular  homeostasis/metabolism  immune system  nervous system  normal 

    NEIL3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NEIL3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Resolution of Abasic Sites (AP sites)
    		Base excision repair0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NEIL3):
        Base excision repair


    NEIL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEIL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NEIL3 (ENSP000002645964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006284base-excision repair ISS--
    GO:0006289nucleotide-excision repair IEA--


    NEIL3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NEIL3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEIL3
    Search CenterWatch for drugs/clinical trials and news about NEIL3 

    Transcripts
    for NEIL3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NEIL3 gene: 
    NM_018248.2  

    Unigene Cluster for NEIL3:

    Nei endonuclease VIII-like 3 (E. coli)
    Hs.405467  [show with all ESTs]
    Unigene Representative Sequence: NM_018248
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264596(uc003iut.2) ENST00000513321(uc010irs.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NEIL3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEIL3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NEIL3:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: NEIL3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEIL3 (see all 4)
    OriGene shRNA RFP: NEIL3
    OriGene siRNA: NEIL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEIL3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NEIL3 (NM_018248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEIL3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEIL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEIL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL3

    Additional cDNA sequence: 

    AB079071.1 AK001720.1 AK307692.1 BC025954.1 

    3 DOTS entries:

    DT.444905  DT.100737072  DT.40125507 

    24/48 AceView cDNA sequences (see all 48):

    BQ054308 CR605089 AA677552 BQ220911 AU154583 BM458786 BU170388 BU689565 
    BP364315 BP374941 AL528027 BQ441413 BX112923 BG026947 NM_018248 AU133212 
    AL528028 AK001720 BQ687469 AI074567 BC025954 BP366116 AI419161 BF509892 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NEIL3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -                                       
    SP2:                                                                                    
    SP3:                    -                                                               


    ECgene alternative splicing isoforms for NEIL3

    Expression
    for NEIL3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEIL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTAACACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NEIL3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NEIL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEIL3

    SOURCE GeneReport for Unigene cluster: Hs.405467

    UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
    Tissue specificity: Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding
    normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue

        SABiosciences Expression via Pathway-Focused PCR Array including NEIL3: 
              DNA Repair in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEIL3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEIL3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEIL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL3

    Orthologs
    for NEIL3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NEIL3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Neil31 , 5 nei like 3 (E. coli)1, 5 80.5(n)1
    74.21(a)1    		   8 (29.14 cM)5
    2342581  NM_146208.21  NP_666320.11 
     535868675 
    chicken
    (Gallus gallus)    		 Aves NEIL31 nei endonuclease VIII-like 3 (E. coli) 66.49(n)
    60.85(a)    		   428750  XM_426306.2  XP_426306.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NEIL36
    		 --
    		 58(a)
    		 1 ↔ 1
    		 5(116928265-116945678)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.105042 Xenopus laevis transcribed sequence with weak similarity more 77.45(n)    BX848153.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.178272 Transcribed sequence with weak similarity to protein more 79.08(n)    AL715431.1 


    ENSEMBL Gene Tree for NEIL3 (if available)
    TreeFam Gene Tree for NEIL3 (if available) 

    Paralogs
    for NEIL3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NEIL3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NEIL3
         3 CNVs: 2558 8465 3528
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEIL3
    DNA2.0 Custom Variant and Variant Library Synthesis for NEIL3

    Disorders / Diseases
    for NEIL3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NEIL3 for disorders           About GeneDecksing

    OMIM gene information: 608934    OMIM disorders: --

    4 diseases for NEIL3:    About MalaCards
    hepatocellular carcinoma    meningioma    adenoma    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: NEIL3 (3 documents)

    Export disorders for NEIL3 gene to outside databases

    Publications
    for NEIL3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEIL3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with NEIL3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and purification of NEIL3, a human DNA glycosylase homolog. (PubMed id 19121397)1, 2, 9 Krokeide S.Z....Luna L. (2009)
    2. Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. (PubMed id 19170771)1, 2, 9 Takao M.... Zhang Q.M. (2009)
    3. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. (PubMed id 12713815)1, 3, 9 Rosenquist T.A....Grollman A.P. (2003)
    4. Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. (PubMed id 12433996)1, 2, 9 Morland I.... Seeberg E. (2002)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. (PubMed id 12509226)1, 3 Bandaru V.... Bond J.P. (2002)
    8. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. (PubMed id 12200441)1, 2 Takao M.... Yasui A. (2002)
    9. Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. (PubMed id 16428305)2, 9 Torisu K.... Nakabeppu Y. (2005)
    10. Expression and purification of active mouse and human NEIL3 proteins. (PubMed id 22569481)1 Liu M....Wallace S.S. (2012)

    External Searches for NEIL3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NEIL3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55247 HGNC: 24573 AceView: FLJ10858 Ensembl:ENSG00000109674 euGenes: HUgn55247
    ECgene: NEIL3 Kegg: 55247 H-InvDB: NEIL3

    Other Databases showing NEIL3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NEIL3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEIL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEIL3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/neil3/

    Intellectual Property
    for NEIL3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NEIL3 gene:
    Search GeneIP for patents involving NEIL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NEIL3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NEIL3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEIL3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEIL3  
     OriGene Protein Over-expression Lysate for NEIL3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NEIL3   OriGene 3'-UTR Clone for NEIL3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEIL3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEIL3   OriGene Custom Protein Services for NEIL3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEIL3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEIL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEIL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEIL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEIL3
     GenScript Custom Purified and Recombinant Proteins Services for NEIL3 GenScript cDNA clones with any tag delivered in your preferred vector for NEIL3
     GenScript Custom Assay Services for NEIL3 GenScript Custom Superior Antibodies Services for NEIL3
     GenScript Custom overexpressing Cell Line Services for NEIL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEIL3 promoter
     Search Chromatin IP Primers for NEIL3
     RT2 qPCR Primer Assay in human, mouse, rat NEIL3
     Search GNC Networks for NEIL3
     SABiosciences PCR Arrays including human, mouse, rat NEIL3
     Search Tocris compounds for NEIL3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEIL3 antibodies
     NEIL3 lysates
     Search for Antibodies for NEIL3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NEIL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NEIL3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NEIL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL3
     SwitchGear 3'UTR luciferase reporter plasmids for NEIL3
     SwitchGear Promoter luciferase reporter plasmids for NEIL3
     ThermoFisher Antibodies for NEIL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NEIL3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4