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NEIL3 Gene

protein-coding   GIFtS: 55
GCID: GC04P178230

Nei Endonuclease VIII-Like 3 (E. Coli)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nei Endonuclease VIII-Like 3 (E. Coli)1 2     NEI32
Endonuclease VIII-Like 32 3     ZGRF32
Nei-Like Protein 32 3     DNA Glycosylase HFPG22
DNA Glycosylase FPG22 3     Endonuclease 8-Like 32
DNA Glycosylase/AP Lyase Neil32 3     hFPG22
GRF-Type Containing 31     hNEI32
Zinc Finger1     Zinc Finger, GRF-Type Containing 32
FGP22     EC 3.2.2.-3
FPG22     EC 4.2.99.183

External Ids:    HGNC: 245731   Entrez Gene: 552472   Ensembl: ENSG000001096747   OMIM: 6089345   UniProtKB: Q8TAT53   

Export aliases for NEIL3 gene to outside databases

Previous GC identifers: GC04P178607 GC04P178468 GC04P173981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEIL3 Gene:
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases
initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and
introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed
12509226)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NEIL3 Gene:
NEIL3 (nei endonuclease VIII-like 3 (E. coli)) is a protein-coding gene. Diseases associated with NEIL3 include meningioma, and adenoma. GO annotations related to this gene include damaged DNA binding and double-stranded DNA binding. An important paralog of this gene is NEIL2.

UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
Function: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble
and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the
hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes
FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows
weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in
removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in
certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in
replication-associated DNA repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEIL3 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   HNF-3beta   Evi-1   GATA-1   IRF-2   Nkx6-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEIL3 promoter sequence
   Search Chromatin IP Primers for NEIL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEIL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.3   Ensembl cytogenetic band:  4q34.3   HGNC cytogenetic band: 4q34

NEIL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEIL3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P178230:  view genomic region     (about GC identifiers)

Start:
178,230,990 bp from pter      End:
178,284,097 bp from pter
Size:
53,108 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5 (See protein sequence)
Recommended Name: Endonuclease 8-like 3  
Size: 605 amino acids; 67769 Da
Developmental stage: Up-regulated during early S phase of the cell cycle, and sustained through G/M phase. Low
expression levels in quiescent cells
Caution: Was originally thought to be inactive as a glycosylase (PMID:12200441,PMID:19121397), but recent reports
(PMID:22569481, PMID:20185759) demonstrate that cleavage of the initiator methionine is essential for catalytic
activity
Secondary accessions: Q2PPJ3 Q8NG51 Q9NV95

Explore the universe of human proteins at neXtProt for NEIL3: NX_Q8TAT5

Explore proteomics data for NEIL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys110, Lys195, Lys316, Lys372, Lys398, Lys558, Lys574, Lys585
  • Modification sites at PhosphoSitePlus

  • See NEIL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060718.2  
    ENSEMBL proteins: 
     ENSP00000264596   ENSP00000424735  

    NEIL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for NEIL3
    Cloud-Clone Corp. CLIAs for NEIL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR010979 Ribosomal_S13-like_H2TH
     IPR012319 DNA_glycosylase/AP_lyase_cat
     IPR000214 Znf_DNA_glyclase/AP_lyase
     IPR015887 DNA_glyclase_Znf_dom_DNA_BS
     IPR010666 Znf_GRF

    Graphical View of Domain Structure for InterPro Entry Q8TAT5

    ProtoNet protein and cluster: Q8TAT5

    1 Blocks protein domain: IPB001876 Zn-finger

    UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
    Domain: The N-terminal region (2-281) contains the glycosylase and lyase activities (By similarity)
    Similarity: Belongs to the FPG family
    Similarity: Contains 1 FPG-type zinc finger
    Similarity: Contains 1 RanBP2-type zinc finger


    NEIL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEIL3_HUMAN, Q8TAT5
    Function: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble
    and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the
    hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes
    FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows
    weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in
    removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in
    certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in
    replication-associated DNA repair
    Catalytic activity: Removes damaged bases from DNA, leaving an abasic site
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate

         Enzyme Numbers (IUBMB): EC 4.2.99.181 EC 3.2.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000405bubble DNA binding ISS--
    GO:0003676nucleic acid binding ----
    GO:0003684damaged DNA binding IEA--
    GO:0003690double-stranded DNA binding ISS--
    GO:0003697single-stranded DNA binding IDA19170771
         
    NEIL3 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Neil3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     normal 

    NEIL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NEIL3: Neil3tm1Yun Neil3tm1Bjor

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEIL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEIL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEIL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEIL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEIL3:
    hsa-mir-192-5p (MIRT026184), hsa-mir-215-5p (MIRT024831)

    Block miRNA regulation of human, mouse, rat NEIL3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NEIL3:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidNEIL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEIL3
    Predesigned siRNA for gene silencing in human, mouse, rat NEIL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEIL3

    Clone
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    OriGene clones in human, mouse for NEIL3 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEIL3 (NM_018248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NEIL3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEIL3_HUMAN, Q8TAT5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12433996

    NEIL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEIL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Base excision repair0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for NEIL3):
        Base excision repair


    NEIL3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NEIL3: 
              DNA Repair in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NEIL3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for NEIL3 (ENSP000002645964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMP3ENSP000003269814STRING: ENSP00000326981
    RPS9ENSP000003028964STRING: ENSP00000302896
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000003123554STRING: ENSP00000312355
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000737DNA catabolic process, endonucleolytic IDA19170771
    GO:0006281DNA repair ----
    GO:0006284base-excision repair ISS--
    GO:0006289nucleotide-excision repair IEA--

    NEIL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEIL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEIL3 gene: 
    NM_018248.2  

    Unigene Cluster for NEIL3:

    Nei endonuclease VIII-like 3 (E. coli)
    Hs.405467  [show with all ESTs]
    Unigene Representative Sequence: NM_018248
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264596(uc003iut.2) ENST00000513321(uc010irs.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NEIL3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NEIL3:
    hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidNEIL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NEIL3
    Predesigned siRNA for gene silencing in human, mouse, rat NEIL3
    Clone
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    OriGene clones in human, mouse for NEIL3 (see all 6)
    OriGene ORF clones in mouse, rat for NEIL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NEIL3 (NM_018248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEIL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEIL3
    Primer
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    OriGene qPCR primer pairs and template standards for NEIL3
    OriGene qSTAR qPCR primer pairs in human, mouse for NEIL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEIL3
      QuantiTect SYBR Green Assays in human, mouse, rat NEIL3
      QuantiFast Probe-based Assays in human, mouse, rat NEIL3

    Additional mRNA sequence: 

    AB079071.1 AK001720.1 AK307692.1 BC025954.1 

    3 DOTS entries:

    DT.444905  DT.100737072  DT.40125507 

    Selected AceView cDNA sequences (see all 48):

    AA677552 BM458786 BQ054308 BU689565 BQ220911 BU170388 CR605089 AU154583 
    BF509892 AI074567 BP364315 BX348730 AI419161 BU173488 BC025954 BG026947 
    AB079071 AU133212 BQ687469 BG495300 BG397668 BP357866 BP374941 AL528028 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NEIL3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -                                       
    SP2:                                                                                    
    SP3:                    -                                                               


    ECgene alternative splicing isoforms for NEIL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEIL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTAACACT
    NEIL3 Expression
    About this image


    NEIL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
    NEIL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEIL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405467

    UniProtKB/Swiss-Prot: NEIL3_HUMAN, Q8TAT5
    Tissue specificity: Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in
    thymus, testis and fetal lung primary fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including NEIL3: 
              DNA Repair in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for NEIL3
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    QuantiFast Probe-based Assays in human, mouse, rat NEIL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NEIL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neil31 , 5 nei like 3 (E. coli)1, 5 80.5(n)1
    74.21(a)1
      8 (29.14 cM)5
    2342581  NM_146208.21  NP_666320.11 
     535868675 
    chicken
    (Gallus gallus)
    Aves NEIL31 nei endonuclease VIII-like 3 (E. coli) 64.82(n)
    58.82(a)
      428750  XM_426306.3  XP_426306.3 
    lizard
    (Anolis carolinensis)
    Reptilia NEIL36
    nei endonuclease VIII-like 3 (E. coli)
    55(a)
    1 ↔ 1
    5(116927738-116966931)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.105042 Xenopus laevis transcribed sequence with weak similarity more 77.45(n)    BX848153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.178272 Transcribed sequence with weak similarity to protein more 79.08(n)    AL715431.1 


    ENSEMBL Gene Tree for NEIL3 (if available)
    TreeFam Gene Tree for NEIL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEIL3 gene
    NEIL22  

    NEIL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEIL3 (see all 1273)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355222231,2
    F--174024371(+) AAAAAGAA/-GATGT 1 -- int15Minor allele frequency- -:0.20NS 168
    rs286655651,2
    C,F--178228999(+) TGACTC/TCGCCT 1 -- us2k13Minor allele frequency- T:0.09WA NA 240
    rs1500922761,2
    --178229001(+) ACTCCA/GCCTTT 1 -- us2k10--------
    rs170645851,2
    C,F,H--178229013(+) AGTCAC/TGCCAG 1 -- us2k121Minor allele frequency- T:0.04NA NS EA WA CSA 1878
    rs1477643001,2
    --178229212(+) TCCCCC/TCCCCT 1 -- us2k10--------
    rs1900658351,2
    --178229317(+) AAAGGA/GCATTG 1 -- us2k10--------
    rs1412607561,2
    --178229337(+) CCTTGA/TCTTCT 1 -- us2k10--------
    rs1929217391,2
    --178229384(+) AGAGCA/CGAGCT 1 -- us2k10--------
    rs738649801,2
    C,F--178229385(+) GAGCCG/CAGCTG 1 -- us2k12Minor allele frequency- C:0.09WA 120
    rs1855538031,2
    --178229458(+) ATCTCA/GGAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEIL3 (178230990 - 178284097 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NEIL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728772CNV Deletion23290073
    nsv508336CNV Loss20534489
    nsv822852CNV Gain20364138
    nsv881529CNV Gain21882294
    esv34846CNV Gain17911159
    essv1584CNV CNV17122850
    dgv1719e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608934    OMIM disorders: --

    5 diseases for NEIL3:    
    About MalaCards
    meningioma    adenoma    hepatocellular carcinoma    retinitis
    endotheliitis


    NEIL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEIL3
    Human Genome Epidemiology (HuGE) Navigator: NEIL3 (3 documents)

    Export disorders for NEIL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEIL3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NEIL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and purification of NEIL3, a human DNA glycosylase homolog. (PubMed id 19121397)1, 2, 9 Krokeide S.Z.... Luna L. (Protein Expr. Purif. 2009)
    2. Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. (PubMed id 19170771)1, 2, 9 Takao M.... Zhang Q.M. (Genes Cells 2009)
    3. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. (PubMed id 12713815)1, 3, 9 Rosenquist T.A....Grollman A.P. (DNA Repair (Amst.) 2003)
    4. Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. (PubMed id 12433996)1, 2, 9 Morland I.... Seeberg E. (Nucleic Acids Res. 2002)
    5. Expression and purification of active mouse and human NEIL3 proteins. (PubMed id 22569481)1, 2 Liu M....Wallace S.S. (Protein Expr. Purif. 2012)
    6. Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway. (PubMed id 22365498)1, 2 Neurauter C.G....rAYs M. (DNA Repair (Amst.) 2012)
    7. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PubMed id 18515411)1, 4 Dallosso A.R....Sampson J.R. (Gut 2008)
    8. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)1, 4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55247 HGNC: 24573 AceView: FLJ10858 Ensembl:ENSG00000109674 euGenes: HUgn55247
    ECgene: NEIL3 Kegg: 55247 H-InvDB: NEIL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEIL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEIL3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/neil3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEIL3 gene:
    Search GeneIP for patents involving NEIL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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