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Aliases for NEIL3 Gene

Aliases for NEIL3 Gene

  • Nei Like DNA Glycosylase 3 2 3
  • DNA Glycosylase/AP Lyase Neil3 3 4
  • Nei-Like DNA Glycosylase 3 3 5
  • Endonuclease VIII-Like 3 3 4
  • DNA Glycosylase FPG2 3 4
  • Nei-Like Protein 3 3 4
  • Nei Endonuclease VIII-Like 3 (E. Coli) 2
  • Zinc Finger, GRF-Type Containing 3 3
  • Nei Endonuclease VIII-Like 3 3
  • GRF-Type Containing 3 2
  • DNA Glycosylase HFPG2 3
  • EC 4.2.99.18 4
  • Zinc Finger 2
  • EC 3.2.2.- 4
  • ZGRF3 3
  • HFPG2 3
  • HNEI3 3
  • FGP2 3
  • FPG2 3
  • NEI3 3

External Ids for NEIL3 Gene

Previous GeneCards Identifiers for NEIL3 Gene

  • GC04P178607
  • GC04P178468
  • GC04P178230
  • GC04P173981

Summaries for NEIL3 Gene

Entrez Gene Summary for NEIL3 Gene

  • NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NEIL3 Gene

NEIL3 (Nei Like DNA Glycosylase 3) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NEIL2.

UniProtKB/Swiss-Prot for NEIL3 Gene

  • DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL3 Gene

Genomics for NEIL3 Gene

Regulatory Elements for NEIL3 Gene

Promoters for NEIL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEIL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEIL3 Gene

Chromosome:
4
Start:
177,309,836 bp from pter
End:
177,362,943 bp from pter
Size:
53,108 bases
Orientation:
Plus strand

Genomic View for NEIL3 Gene

Genes around NEIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL3 Gene

Proteins for NEIL3 Gene

  • Protein details for NEIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT5-NEIL3_HUMAN
    Recommended name:
    Endonuclease 8-like 3
    Protein Accession:
    Q8TAT5
    Secondary Accessions:
    • Q2PPJ3
    • Q8NG51
    • Q9NV95

    Protein attributes for NEIL3 Gene

    Size:
    605 amino acids
    Molecular mass:
    67769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEIL3 Gene

Proteomics data for NEIL3 Gene at MOPED

Post-translational modifications for NEIL3 Gene

  • Ubiquitination at Lys 13, Lys 110, Lys 195, Lys 316, Lys 372, Lys 398, Lys 558, Lys 574, and Lys 585
  • Modification sites at PhosphoSitePlus

Other Protein References for NEIL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NEIL3 Gene

Domains & Families for NEIL3 Gene

Suggested Antigen Peptide Sequences for NEIL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAT5

UniProtKB/Swiss-Prot:

NEIL3_HUMAN :
  • The N-terminal region (2-281) contains the glycosylase and lyase activities.
  • Belongs to the FPG family.
  • Contains 1 FPG-type zinc finger.
Domain:
  • The N-terminal region (2-281) contains the glycosylase and lyase activities.
Family:
  • Belongs to the FPG family.
Similarity:
  • Contains 1 FPG-type zinc finger.
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with NEIL3: view

Function for NEIL3 Gene

Molecular function for NEIL3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Removes damaged bases from DNA, leaving an abasic site.
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot Function:
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Enzyme Numbers (IUBMB) for NEIL3 Gene

Gene Ontology (GO) - Molecular Function for NEIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000405 bubble DNA binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA,ISS --
GO:0003697 single-stranded DNA binding IEA,IDA 19170771
genes like me logo Genes that share ontologies with NEIL3: view
genes like me logo Genes that share phenotypes with NEIL3: view

Animal Models for NEIL3 Gene

MGI Knock Outs for NEIL3:

Animal Model Products

miRNA for NEIL3 Gene

miRTarBase miRNAs that target NEIL3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEIL3 Gene

Localization for NEIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEIL3 Gene COMPARTMENTS Subcellular localization image for NEIL3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for NEIL3 Gene

Pathways & Interactions for NEIL3 Gene

genes like me logo Genes that share pathways with NEIL3: view

Pathways by source for NEIL3 Gene

1 KEGG pathway for NEIL3 Gene

Interacting Proteins for NEIL3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264596%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000264596 for NEIL3 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NEIL3 Gene

None

No data available for SIGNOR curated interactions for NEIL3 Gene

Drugs & Compounds for NEIL3 Gene

No Compound Related Data Available

Transcripts for NEIL3 Gene

mRNA/cDNA for NEIL3 Gene

Unigene Clusters for NEIL3 Gene

Nei endonuclease VIII-like 3 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: -

Relevant External Links for NEIL3 Gene

GeneLoc Exon Structure for
NEIL3
ECgene alternative splicing isoforms for
NEIL3

Expression for NEIL3 Gene

mRNA expression in normal human tissues for NEIL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEIL3 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NEIL3 Gene



SOURCE GeneReport for Unigene cluster for NEIL3 Gene Hs.405467

mRNA Expression by UniProt/SwissProt for NEIL3 Gene

Q8TAT5-NEIL3_HUMAN
Tissue specificity: Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
genes like me logo Genes that share expression patterns with NEIL3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NEIL3 Gene

Orthologs for NEIL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL3 35
  • 99.01 (n)
  • 97.85 (a)
NEIL3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEIL3 36
  • 78 (a)
OneToOne
NEIL3 35
  • 85.26 (n)
  • 78.31 (a)
dog
(Canis familiaris)
Mammalia NEIL3 35
  • 83.8 (n)
  • 78.87 (a)
NEIL3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neil3 36
  • 73 (a)
OneToOne
Neil3 16
Neil3 35
  • 80.5 (n)
  • 74.21 (a)
oppossum
(Monodelphis domestica)
Mammalia NEIL3 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neil3 35
  • 80 (n)
  • 72.89 (a)
chicken
(Gallus gallus)
Aves NEIL3 36
  • 56 (a)
OneToOne
NEIL3 35
  • 64.82 (n)
  • 58.82 (a)
lizard
(Anolis carolinensis)
Reptilia NEIL3 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10504 35
tropical clawed frog
(Silurana tropicalis)
Amphibia neil3 35
  • 62.25 (n)
  • 57.42 (a)
Str.6541 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3316 35
zebrafish
(Danio rerio)
Actinopterygii neil3 36
  • 54 (a)
OneToMany
Dr.17827 35
neil3 35
  • 59.16 (n)
  • 56.04 (a)
Species with no ortholog for NEIL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL3 Gene

ENSEMBL:
Gene Tree for NEIL3 (if available)
TreeFam:
Gene Tree for NEIL3 (if available)

Paralogs for NEIL3 Gene

Paralogs for NEIL3 Gene

genes like me logo Genes that share paralogs with NEIL3: view

Variants for NEIL3 Gene

Sequence variations from dbSNP and Humsavar for NEIL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7689099 - 177,335,759(+) TTCTC(C/G/T)TGTTT reference, missense
VAR_020591 -
VAR_020592 -
rs34007209 - 177,310,065(+) AGGGC(C/T)GCGCC reference, missense
rs34112288 - 177,322,528(+) GTGGC(A/G/T)TGGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NEIL3 Gene

Variant ID Type Subtype PubMed ID
esv2728772 CNV Deletion 23290073
nsv881529 CNV Gain 21882294
dgv1719e1 CNV Complex 17122850
essv1584 CNV CNV 17122850
nsv822852 CNV Gain 20364138
esv34846 CNV Gain 17911159
nsv508336 CNV Loss 20534489

Variation tolerance for NEIL3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEIL3 Gene

HapMap Linkage Disequilibrium report
NEIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEIL3 Gene

Disorders for NEIL3 Gene

Relevant External Links for NEIL3

Genetic Association Database (GAD)
NEIL3
Human Genome Epidemiology (HuGE) Navigator
NEIL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEIL3

No disorders were found for NEIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEIL3 Gene

Publications for NEIL3 Gene

  1. Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. (PMID: 19170771) Takao M. … Zhang Q.M. (Genes Cells 2009) 2 3 4 23 67
  2. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. (PMID: 12713815) Rosenquist T.A. … Grollman A.P. (DNA Repair (Amst.) 2003) 2 3 23
  3. Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. (PMID: 23755964) Krokeide S.Z. … Bjoras M. (DNA Repair 2013) 2 3
  4. Expression and purification of NEIL3, a human DNA glycosylase homolog. (PMID: 19121397) Krokeide S.Z. … Luna L. (Protein Expr. Purif. 2009) 3 23
  5. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. (PMID: 12509226) Bandaru V. … Bond J.P. (DNA Repair 2002) 2 3

Products for NEIL3 Gene

Sources for NEIL3 Gene

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