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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEIL2 Gene

protein-coding   GIFtS: 57
GCID: GC08P011627

Nei Endonuclease VIII-Like 2 (E. Coli)

(Previous name: nei like 2 (E. coli))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nei Endonuclease VIII-Like 2 (E. Coli)1 2     Nei Like 2 (E. Coli)1
Endonuclease VIII-Like 22 3     NEI22
Nei Homolog 22 3     Endonuclease 8-Like 22
Nei-Like Protein 22 3     Nei Like 22
NEH22 3     EC 3.2.2.-3
DNA Glycosylase/AP Lyase Neil22 3     EC 4.2.99.183
DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil22 3     

External Ids:    HGNC: 189561   Entrez Gene: 2529692   Ensembl: ENSG000001543287   OMIM: 6089335   UniProtKB: Q969S23   

Export aliases for NEIL2 gene to outside databases

Previous GC identifers: GC08U990169 GC08P011619 GC08P011498 GC08P011664 GC08P010558


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEIL2 Gene:
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases
initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and
introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed
12509226))(supplied by OMIM, Mar 2008)

GeneCards Summary for NEIL2 Gene: 
NEIL2 (nei endonuclease VIII-like 2 (E. coli)) is a protein-coding gene. Diseases associated with NEIL2 include familial colorectal cancer, and colorectal cancer, and among its related super-pathways are Resolution of Abasic Sites (AP sites). GO annotations related to this gene include microtubule binding and DNA-(apurinic or apyrimidinic site) lyase activity. An important paralog of this gene is NEIL3.

UniProtKB/Swiss-Prot: NEIL2_HUMAN, Q969S2
Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase
activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched
double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol,
2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces
nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at
the site of the removed base with both 3'- and 5'-phosphates

Gene Wiki entry for NEIL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_077531.4  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEIL2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   Nkx3-1 v2   IRF-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEIL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEIL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEIL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

NEIL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEIL2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P011627:  view genomic region     (about GC identifiers)

Start:
11,627,148 bp from pter      End:
11,644,855 bp from pter
Size:
17,708 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEIL2_HUMAN, Q969S2 (See protein sequence)
Recommended Name: Endonuclease 8-like 2  
Size: 332 amino acids; 36826 Da
Subunit: Binds EP300
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for NEIL2:
1VZP (3D)    
Secondary accessions: B4DFR7 Q7Z3Q7 Q8N842 Q8NG52
Alternative splicing: 4 isoforms:  Q969S2-1   Q969S2-2   Q969S2-3   Q969S2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEIL2: NX_Q969S2

Explore proteomics data for NEIL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969S2

  • NEIL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEIL2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129218.1  NP_001129219.1  NP_001129220.1  NP_659480.1  

    ENSEMBL proteins: 
     ENSP00000394023   ENSP00000397538   ENSP00000384070   ENSP00000437004   ENSP00000435657  
     ENSP00000284503  

    Human Recombinant Protein Products for NEIL2: 
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    Novus Biologicals NEIL2 Proteins
    Novus Biologicals NEIL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NEIL2
    Cloud-Clone Corp. Proteins for NEIL2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule ----
    GO:0005876spindle microtubule IEA--

    NEIL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for NEIL2 
    Cloud-Clone Corp. CLIAs for NEIL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR010979 Ribosomal_S13-like_H2TH
     IPR012319 DNA_glycosylase/AP_lyase_cat
     IPR000214 Znf_DNA_glyclase/AP_lyase
     IPR015886 DNA_glyclase/AP_lyase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q969S2

    ProtoNet protein and cluster: Q969S2

    UniProtKB/Swiss-Prot: NEIL2_HUMAN, Q969S2
    Domain: The zinc-finger domain is important for DNA binding
    Similarity: Belongs to the FPG family
    Similarity: Contains 1 FPG-type zinc finger


    NEIL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEIL2_HUMAN, Q969S2
    Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase
    activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched
    double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol,
    2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces
    nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at
    the site of the removed base with both 3'- and 5'-phosphates
    Catalytic activity: Removes damaged bases from DNA, leaving an abasic site
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
    Enzyme regulation: Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no
    effect

         Enzyme Numbers (IUBMB): EC 4.2.99.181 EC 3.2.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003684damaged DNA binding IEA--
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IEA--
    GO:0008017microtubule binding IEA--
    GO:0008270zinc ion binding IEA--
         
    NEIL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEIL2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEIL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEIL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEIL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEIL2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NEIL2:
    hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidNEIL2 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of NEIL2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEIL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Base excision repair0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for NEIL2):
        Base excision repair


    NEIL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEIL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for NEIL2 (Q969S23 ENSP000002845034) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    KEAP1ENSP000001711114STRING: ENSP00000171111
    ARL3ENSP000002607464STRING: ENSP00000260746
    AURKAENSP000002169114STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ----
    GO:0006284base-excision repair IEA--
    GO:0006289nucleotide-excision repair IEA--

    NEIL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEIL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEIL2

    2 Novoseek inferred chemical compound relationships for NEIL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphonate 57.5 2 16982218 (1), 15260972 (1)
    oxygen 8.24 1 17389588 (1)

    Search CenterWatch for drugs/clinical trials and news about NEIL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEIL2 gene (4 alternative transcripts): 
    NM_001135746.1  NM_001135747.1  NM_001135748.1  NM_145043.2  

    Unigene Cluster for NEIL2:

    Nei endonuclease VIII-like 2 (E. coli)
    Hs.293818  [show with all ESTs]
    Unigene Representative Sequence: NM_145043
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436750 ENST00000455213(uc003wue.2 uc003wuf.2 uc011kxd.1)
    ENST00000403422 ENST00000528113 ENST00000528323 ENST00000284503(uc003wug.2)
    ENST00000524741
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NEIL2:
    hsa-miR-708*
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEIL2

    Additional mRNA sequence: 

    AB079070.1 AK056206.1 AK097389.1 AK225837.1 AK294224.1 BC013952.2 BC013964.2 BC045822.1 
    BX537529.1 

    9 DOTS entries:

    DT.101983895  DT.113142  DT.100781585  DT.100781581  DT.100023162  DT.97841160  DT.120635439  DT.95204667 
    DT.120635434 

    24/136 AceView cDNA sequences (see all 136):

    BU189576 BQ942628 T55606 BG759722 BU158642 BM466367 CR600966 BX341864 
    BI522685 BI601338 Z43722 BP363821 BC013964 CF147070 BC045822 BI966730 
    BM968316 AI273686 CD558091 BX333648 BQ012227 BQ776105 BM685952 CB243609 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NEIL2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                    -                                                   
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                    -     -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for NEIL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEIL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATAAAGC
    NEIL2 Expression
    About this image


    See NEIL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEIL2

    SOURCE GeneReport for Unigene cluster: Hs.293818

    UniProtKB/Swiss-Prot: NEIL2_HUMAN, Q969S2
    Tissue specificity: Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver

        SABiosciences Expression via Pathway-Focused PCR Array including NEIL2: 
              DNA Repair in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEIL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NEIL2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Neil21 , 5 nei like 2 (E. coli)1, 5 79.01(n)1
    75.93(a)1
      14 (33.24 cM)5
    3829131  NM_201610.21  NP_963904.21 
     631824455 
    chicken
    (Gallus gallus)
    Aves NEIL21 nei endonuclease VIII-like 2 (E. coli) 64.5(n)
    57.98(a)
      422037  XM_420042.1  XP_420042.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEIL26
    nei endonuclease VIII-like 2 (E. coli)
    50(a)
    1 ↔ 1
    GL343704.1(155389-162465)


    ENSEMBL Gene Tree for NEIL2 (if available)
    TreeFam Gene Tree for NEIL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEIL2 gene
    NEIL32  

    NEIL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NEIL2
    PGOHUM00000245728


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/677 SNPs in NEIL2 are shown (see all 677)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8042751,2
    C,A,H--11625187(-) AAGTAG/CCTGGG 4 -- us2k19Minor allele frequency- C:0.06NA WA CSA 18
    rs8042741,2
    C,F,A,H--11625205(-) CTCCCG/TCCTCA 4 -- us2k1 tfbs37Minor allele frequency- T:0.50NA WA CSA 16
    rs562962791,2
    C--11625214(+) AGAATC/GCCTTG 4 -- us2k10--------
    rs8042731,2
    C,F,A,H--11625235(-) GCAACG/CTCTGC 4 -- us2k14Minor allele frequency- C:0.50NA WA 8
    rs8042721,2
    C--11625245(-) CCAGCT/GAACTG 4 -- us2k14Minor allele frequency- G:0.28NA EA 244
    rs1157468171,2
    F--11625254(+) GGGATC/TGTGCC 4 -- us2k11Minor allele frequency- T:0.01WA 118
    rs771851471,2
    C--11625353(+) CAGCGA/TCACCC 4 -- us2k10--------
    rs1866484541,2
    --11625356(+) CGTCAC/GCCAGC 4 -- us2k10--------
    rs558658391,2
    C,F--11625372(+) GCTGGA/CAAGGC 4 -- us2k14Minor allele frequency- C:0.14NA WA 242
    rs119870231,2
    C,H--11625406(+) ccttaG/Aaatct 4 -- us2k14Minor allele frequency- A:0.00NS EA 410

    HapMap Linkage Disequilibrium report for NEIL2 (11627148 - 11644855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NEIL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736611CNV Deletion23290073
    esv2736612CNV Deletion23290073
    nsv890362CNV Loss21882294
    nsv890361CNV Gain21882294
    nsv890360CNV Gain21882294


    Human Gene Mutation Database (HGMD): NEIL2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608933    OMIM disorders: --

    9 diseases for NEIL2:    About MalaCards
    familial colorectal cancer    colorectal cancer    hepatitis c    multiple sclerosis
    adenoma    squamous cell carcinoma    hepatitis    lung cancer
    breast cancer


    NEIL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NEIL2
    Human Genome Epidemiology (HuGE) Navigator: NEIL2 (7 documents)

    Export disorders for NEIL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEIL2 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with NEIL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. (PubMed id 12097317)1, 2, 3 Hazra T.K.... Izumi T. (2002)
    2. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. (PubMed id 18594018)1, 4, 9 Zhai X....Wei Q. (2008)
    3. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. (PubMed id 17686777)1, 3, 9 Das S....Hazra T.K. (2007)
    4. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PubMed id 18515411)1, 4, 9 Dallosso A.R....Sampson J.R. (2008)
    5. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PubMed id 14522990)1, 2, 9 Dou H.... Hazra T.K. (2003)
    6. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (2011)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    8. Comprehensive screen of genetic variation in DNA repa ir pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (2010)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (2010)
    10. Identification of a zinc finger domain in the human NEIL2 (Nei-like- 2) protein. (PubMed id 15339932)1, 2 Das A....Hazra T.K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 252969 HGNC: 18956 AceView: NEIL2 Ensembl:ENSG00000154328 euGenes: HUgn252969
    ECgene: NEIL2 Kegg: 252969 H-InvDB: NEIL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEIL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEIL2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/neil2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEIL2 gene:
    Search GeneIP for patents involving NEIL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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