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Aliases for NEIL2 Gene

Aliases for NEIL2 Gene

  • Nei Like DNA Glycosylase 2 2 3 5
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil2 3 4
  • DNA Glycosylase/AP Lyase Neil2 3 4
  • Nei-Like Protein 2 3 4
  • Nei Homolog 2 3 4
  • NEH2 3 4
  • Nei Endonuclease VIII-Like 2 (E. Coli) 2
  • Nei Endonuclease VIII-Like 2 3
  • Endonuclease VIII-Like 2 4
  • Endonuclease 8-Like 2 3
  • Nei Like 2 (E. Coli) 2
  • EC 4.2.99.18 4
  • EC 3.2.2.- 4
  • NEI2 3

External Ids for NEIL2 Gene

Previous GeneCards Identifiers for NEIL2 Gene

  • GC08U990169
  • GC08P011619
  • GC08P011498
  • GC08P011664
  • GC08P010558
  • GC08P011627

Summaries for NEIL2 Gene

Entrez Gene Summary for NEIL2 Gene

  • This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

GeneCards Summary for NEIL2 Gene

NEIL2 (Nei Like DNA Glycosylase 2) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Depyrimidination. GO annotations related to this gene include nucleic acid binding and damaged DNA binding. An important paralog of this gene is NEIL3.

UniProtKB/Swiss-Prot for NEIL2 Gene

  • Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Gene Wiki entry for NEIL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL2 Gene

Genomics for NEIL2 Gene

Regulatory Elements for NEIL2 Gene

Enhancers for NEIL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G011795 1.3 Ensembl ENCODE dbSUPER 28.1 +27.0 27012 2.6 HDAC1 PKNOX1 GATA2 SMARCA5 NFYC ZFP69B ZSCAN16 BCL6B IKZF1 NBN NEIL2 CTSB C8orf49 FDFT1 LOC105379243
GH08G011768 1.1 ENCODE 22.8 +0.3 257 2.7 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 NEIL2 FDFT1 LOC105379243 C8orf49 CTSB LOC105379241 BLK ENSG00000269918 PIR40911
GH08G011765 1.3 Ensembl ENCODE dbSUPER 17.7 -4.0 -4024 1.0 ARID4B ZNF2 RAD21 YY1 SCRT2 ZNF143 CREM MIXL1 ZNF654 USF2 NEIL2 C8orf49
GH08G011761 1.4 Ensembl ENCODE dbSUPER 14.5 -7.3 -7258 1.1 PKNOX1 ATF1 ARNT ZSCAN4 ZBTB40 TCF12 GATA2 EGR1 FOS ETV6 NEIL2 C8orf49
GH08G011739 1.9 VISTA Ensembl ENCODE dbSUPER 9.8 -27.5 -27522 5.7 FOXA2 ATF1 TBL1XR1 FEZF1 RAD21 ZNF121 GLIS2 ELK1 SCRT2 ZNF548 PINX1 LOC101929290 ENSG00000269918 NEIL2 LOC105379241 FDFT1 ENSG00000269954 FAM85A ENSG00000270154 FAM167A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEIL2 on UCSC Golden Path with GeneCards custom track

Promoters for NEIL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221109 161 1601 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1

Genomic Location for NEIL2 Gene

Chromosome:
8
Start:
11,769,639 bp from pter
End:
11,787,346 bp from pter
Size:
17,708 bases
Orientation:
Plus strand

Genomic View for NEIL2 Gene

Genes around NEIL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEIL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL2 Gene

Proteins for NEIL2 Gene

  • Protein details for NEIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S2-NEIL2_HUMAN
    Recommended name:
    Endonuclease 8-like 2
    Protein Accession:
    Q969S2
    Secondary Accessions:
    • B4DFR7
    • Q7Z3Q7
    • Q8N842
    • Q8NG52

    Protein attributes for NEIL2 Gene

    Size:
    332 amino acids
    Molecular mass:
    36826 Da
    Quaternary structure:
    • Binds EP300.

    Three dimensional structures from OCA and Proteopedia for NEIL2 Gene

    Alternative splice isoforms for NEIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEIL2 Gene

Post-translational modifications for NEIL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEIL2 Gene

Domains & Families for NEIL2 Gene

Gene Families for NEIL2 Gene

Suggested Antigen Peptide Sequences for NEIL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q969S2

UniProtKB/Swiss-Prot:

NEIL2_HUMAN :
  • The zinc-finger domain is important for DNA binding.
  • Belongs to the FPG family.
Domain:
  • The zinc-finger domain is important for DNA binding.
Family:
  • Belongs to the FPG family.
genes like me logo Genes that share domains with NEIL2: view

Function for NEIL2 Gene

Molecular function for NEIL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Removes damaged bases from DNA, leaving an abasic site.
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no effect.
UniProtKB/Swiss-Prot Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Enzyme Numbers (IUBMB) for NEIL2 Gene

Gene Ontology (GO) - Molecular Function for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IEA --
GO:0003824 catalytic activity IEA --
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NEIL2: view
genes like me logo Genes that share phenotypes with NEIL2: view

Animal Models for NEIL2 Gene

MGI Knock Outs for NEIL2:

Animal Model Products

CRISPR Products

miRNA for NEIL2 Gene

miRTarBase miRNAs that target NEIL2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEIL2 Gene

Localization for NEIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEIL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005876 spindle microtubule IEA --
genes like me logo Genes that share ontologies with NEIL2: view

Pathways & Interactions for NEIL2 Gene

genes like me logo Genes that share pathways with NEIL2: view

Gene Ontology (GO) - Biological Process for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair IEA --
GO:0006289 nucleotide-excision repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NEIL2: view

No data available for SIGNOR curated interactions for NEIL2 Gene

Drugs & Compounds for NEIL2 Gene

(1) Drugs for NEIL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEIL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEIL2: view

Transcripts for NEIL2 Gene

Unigene Clusters for NEIL2 Gene

Nei endonuclease VIII-like 2 (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6: - - -

Relevant External Links for NEIL2 Gene

GeneLoc Exon Structure for
NEIL2
ECgene alternative splicing isoforms for
NEIL2

Expression for NEIL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEIL2 Gene

Protein differential expression in normal tissues from HIPED for NEIL2 Gene

This gene is overexpressed in Testis (17.0), Retina (15.7), Peripheral blood mononuclear cells (11.9), and Fetal ovary (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEIL2 Gene



Protein tissue co-expression partners for NEIL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEIL2 Gene:

NEIL2

SOURCE GeneReport for Unigene cluster for NEIL2 Gene:

Hs.293818

mRNA Expression by UniProt/SwissProt for NEIL2 Gene:

Q969S2-NEIL2_HUMAN
Tissue specificity: Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.

Evidence on tissue expression from TISSUES for NEIL2 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NEIL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEIL2 Gene

Orthologs for NEIL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL2 35 34
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NEIL2 35 34
  • 80.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Neil2 34 16 35
  • 79.44 (n)
rat
(Rattus norvegicus)
Mammalia Neil2 34
  • 78.88 (n)
cow
(Bos Taurus)
Mammalia NEIL2 34 35
  • 77.13 (n)
oppossum
(Monodelphis domestica)
Mammalia NEIL2 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEIL2 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEIL2 35 34
  • 64.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEIL2 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neil2 34
  • 56.97 (n)
zebrafish
(Danio rerio)
Actinopterygii neil3 35
  • 13 (a)
OneToMany
Species where no ortholog for NEIL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL2 Gene

ENSEMBL:
Gene Tree for NEIL2 (if available)
TreeFam:
Gene Tree for NEIL2 (if available)

Paralogs for NEIL2 Gene

Paralogs for NEIL2 Gene

Pseudogenes.org Pseudogenes for NEIL2 Gene

genes like me logo Genes that share paralogs with NEIL2: view

Variants for NEIL2 Gene

Sequence variations from dbSNP and Humsavar for NEIL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs886043178 Uncertain significance 11,779,844(+) CTGGG(-/A)GGTGG intron-variant, reference, frameshift-variant
rs1000086539 -- 11,773,968(+) GGACT(C/G)ACAGT intron-variant
rs1000266962 -- 11,784,479(+) GAATC(C/T)AGGTG intron-variant
rs1000429127 -- 11,769,687(+) CGGAG(G/T)CCGCA upstream-variant-2KB, utr-variant-5-prime
rs1000485662 -- 11,776,486(+) CTATG(C/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEIL2 Gene

Variant ID Type Subtype PubMed ID
esv3572513 CNV loss 25503493
esv3616258 CNV loss 21293372
nsv1032739 CNV loss 25217958
nsv479711 CNV novel sequence insertion 20440878

Variation tolerance for NEIL2 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEIL2 Gene

Human Gene Mutation Database (HGMD)
NEIL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEIL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEIL2 Gene

Disorders for NEIL2 Gene

Relevant External Links for NEIL2

Genetic Association Database (GAD)
NEIL2
Human Genome Epidemiology (HuGE) Navigator
NEIL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEIL2

No disorders were found for NEIL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEIL2 Gene

Publications for NEIL2 Gene

  1. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. (PMID: 18594018) Zhai X. … Wei Q. (Clin. Cancer Res. 2008) 3 22 46 64
  2. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PMID: 18515411) Dallosso A.R. … Sampson J.R. (Gut 2008) 3 22 46 64
  3. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. (PMID: 17686777) Das S. … Hazra T.K. (J. Biol. Chem. 2007) 2 3 22 64
  4. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PMID: 14522990) Dou H. … Hazra T.K. (J. Biol. Chem. 2003) 3 4 22 64
  5. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. (PMID: 12097317) Hazra T.K. … Izumi T. (J. Biol. Chem. 2002) 2 3 4 64

Products for NEIL2 Gene

Sources for NEIL2 Gene

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