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Aliases for NEIL2 Gene

Aliases for NEIL2 Gene

  • Nei Endonuclease VIII-Like 2 (E. Coli) 2 3
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil2 3 4
  • DNA Glycosylase/AP Lyase Neil2 3 4
  • Endonuclease VIII-Like 2 3 4
  • Nei-Like Protein 2 3 4
  • Nei Homolog 2 3 4
  • NEH2 3 4
  • Endonuclease 8-Like 2 3
  • Nei Like 2 (E. Coli) 2
  • EC 4.2.99.18 4
  • Nei Like 2 3
  • EC 3.2.2.- 4
  • NEI2 3

External Ids for NEIL2 Gene

Summaries for NEIL2 Gene

Entrez Gene Summary for NEIL2 Gene

  • NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]

GeneCards Summary for NEIL2 Gene

NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)) is a Protein Coding gene. Among its related pathways are Resolution of Abasic Sites (AP sites). GO annotations related to this gene include microtubule binding and DNA-(apurinic or apyrimidinic site) lyase activity. An important paralog of this gene is NEIL3.

UniProtKB/Swiss-Prot for NEIL2 Gene

  • Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Gene Wiki entry for NEIL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL2 Gene

Genomics for NEIL2 Gene

Genomic Location for NEIL2 Gene

Start:
11,769,639 bp from pter
End:
11,787,346 bp from pter
Size:
17,708 bases
Orientation:
Plus strand

Genomic View for NEIL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL2 Gene

Proteins for NEIL2 Gene

  • Protein details for NEIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S2-NEIL2_HUMAN
    Recommended name:
    Endonuclease 8-like 2
    Protein Accession:
    Q969S2
    Secondary Accessions:
    • B4DFR7
    • Q7Z3Q7
    • Q8N842
    • Q8NG52

    Protein attributes for NEIL2 Gene

    Size:
    332 amino acids
    Molecular mass:
    36826 Da
    Quaternary structure:
    • Binds EP300

    Three dimensional structures from OCA and Proteopedia for NEIL2 Gene

    Alternative splice isoforms for NEIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEIL2 Gene

Proteomics data for NEIL2 Gene at MOPED

Post-translational modifications for NEIL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEIL2 Gene

Domains for NEIL2 Gene

UniProtKB/Swiss-Prot:

NEIL2_HUMAN
Domain:
  • The zinc-finger domain is important for DNA binding:
    • Q969S2
Family:
  • Belongs to the FPG family.:
    • Q969S2
Similarity:
  • Contains 1 FPG-type zinc finger.:
    • Q969S2
genes like me logo Genes that share domains with NEIL2: view

No data available for Gene Families for NEIL2 Gene

Function for NEIL2 Gene

Molecular function for NEIL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Removes damaged bases from DNA, leaving an abasic site
UniProtKB/Swiss-Prot CatalyticActivity: The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Acetylation of Lys-50 leads to loss of DNA nicking activity. Acetylation of Lys-154 has no effect
UniProtKB/Swiss-Prot Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.

Enzyme Numbers (IUBMB) for NEIL2 Gene

Gene Ontology (GO) - Molecular Function for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003684 damaged DNA binding IEA --
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with NEIL2: view

Phenotypes for NEIL2 Gene

GenomeRNAi human phenotypes for NEIL2:
genes like me logo Genes that share phenotypes with NEIL2: view

miRNA for NEIL2 Gene

miRTarBase miRNAs that target NEIL2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NEIL2 Gene

Localization for NEIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEIL2 Gene COMPARTMENTS Subcellular localization image for NEIL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005876 spindle microtubule IEA --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with NEIL2: view

Pathways for NEIL2 Gene

SuperPathways for NEIL2 Gene

Superpath Contained pathways
1 Resolution of Abasic Sites (AP sites)
genes like me logo Genes that share pathways with NEIL2: view

Pathways by source for NEIL2 Gene

1 KEGG pathway for NEIL2 Gene

Gene Ontology (GO) - Biological Process for NEIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0006289 nucleotide-excision repair IEA --
genes like me logo Genes that share ontologies with NEIL2: view

Compounds for NEIL2 Gene

(2) Novoseek inferred chemical compound relationships for NEIL2 Gene

Compound -log(P) Hits PubMed IDs
phosphonate 57.5 2
oxygen 8.24 1
genes like me logo Genes that share compounds with NEIL2: view

Transcripts for NEIL2 Gene

Unigene Clusters for NEIL2 Gene

Nei endonuclease VIII-like 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: -
SP3:
SP4: - -
SP5:
SP6: - - -

Relevant External Links for NEIL2 Gene

GeneLoc Exon Structure for
NEIL2
ECgene alternative splicing isoforms for
NEIL2

Expression for NEIL2 Gene

mRNA expression in normal human tissues for NEIL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEIL2 Gene

SOURCE GeneReport for Unigene cluster for NEIL2 Gene Hs.293818

mRNA Expression by UniProt/SwissProt for NEIL2 Gene

Q969S2-NEIL2_HUMAN
Tissue specificity: Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
genes like me logo Genes that share expressions with NEIL2: view

Orthologs for NEIL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL2 36
  • 99.3 (n)
  • 98.8 (a)
NEIL2 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEIL2 36
  • 77.13 (n)
  • 72.62 (a)
NEIL2 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEIL2 36
  • 80.92 (n)
  • 74.1 (a)
NEIL2 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neil2 36
  • 79.44 (n)
  • 76.32 (a)
Neil2 16
Neil2 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEIL2 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEIL2 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neil2 36
  • 78.88 (n)
  • 75.78 (a)
chicken
(Gallus gallus)
Aves NEIL2 36
  • 64.29 (n)
  • 57.61 (a)
NEIL2 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEIL2 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neil2 36
  • 56.97 (n)
  • 50.98 (a)
zebrafish
(Danio rerio)
Actinopterygii neil3 37
  • 13 (a)
OneToMany
Species with no ortholog for NEIL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL2 Gene

ENSEMBL:
Gene Tree for NEIL2 (if available)
TreeFam:
Gene Tree for NEIL2 (if available)

Paralogs for NEIL2 Gene

Paralogs for NEIL2 Gene

Pseudogenes.org Pseudogenes for NEIL2 Gene

genes like me logo Genes that share paralogs with NEIL2: view

Variants for NEIL2 Gene

Sequence variations from dbSNP and Humsavar for NEIL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4639 -- 11,787,242(-) ATTGT(C/T)CAACA utr-variant-3-prime
rs804255 -- 11,779,361(-) CATGC(A/T)AGATG intron-variant
rs804256 -- 11,779,353(-) ATGGC(A/G)AGGCC intron-variant
rs804257 -- 11,777,404(-) gtaaa(G/T)tttgt intron-variant
rs804258 -- 11,777,300(-) AAAAG(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEIL2 Gene

Variant ID Type Subtype PubMed ID
nsv890360 CNV Gain 21882294
nsv890361 CNV Gain 21882294
nsv890362 CNV Loss 21882294
esv2736611 CNV Deletion 23290073
esv2736612 CNV Deletion 23290073

Relevant External Links for NEIL2 Gene

HapMap Linkage Disequilibrium report
NEIL2
Human Gene Mutation Database (HGMD)
NEIL2

Disorders for NEIL2 Gene

Relevant External Links for NEIL2

Genetic Association Database (GAD)
NEIL2
Human Genome Epidemiology (HuGE) Navigator
NEIL2
genes like me logo Genes that share disorders with NEIL2: view

No data available for UniProtKB/Swiss-Prot for NEIL2 Gene

Publications for NEIL2 Gene

  1. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PMID: 14522990) Dou H. … Hazra T.K. (J. Biol. Chem. 2003) 3 4 23
  2. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. (PMID: 17686777) Das S. … Hazra T.K. (J. Biol. Chem. 2007) 2 3 23
  3. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PMID: 18515411) Dallosso A.R. … Sampson J.R. (Gut 2008) 3 23 49
  4. Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. (PMID: 18594018) Zhai X. … Wei Q. (Clin. Cancer Res. 2008) 3 23 49
  5. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. (PMID: 12097317) Hazra T.K. … Izumi T. (J. Biol. Chem. 2002) 2 3 4

Products for NEIL2 Gene

Sources for NEIL2 Gene

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