Aliases for NEIL2 Gene
External Ids for NEIL2 Gene
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
GeneCards Summary for NEIL2 Gene
NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)) is a Protein Coding gene. Among its related pathways are Resolution of Abasic Sites (AP sites). GO annotations related to this gene include microtubule binding and DNA-(apurinic or apyrimidinic site) lyase activity. An important paralog of this gene is NEIL3.
UniProtKB/Swiss-Prot for NEIL2 Gene
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates.