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Aliases for NEIL1 Gene

Aliases for NEIL1 Gene

  • Nei Like DNA Glycosylase 1 2 3
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil1 3 4
  • DNA Endonuclease Eight-Like Glycosylase 1 2 3
  • DNA Glycosylase/AP Lyase Neil1 3 4
  • Nei-Like DNA Glycosylase 1 3 5
  • Endonuclease VIII-Like 1 3 4
  • Nei-Like Protein 1 3 4
  • Nei Homolog 1 3 4
  • FPG1 3 4
  • NEH1 3 4
  • Nei Endonuclease VIII-Like 1 (E. Coli) 2
  • Nei Endonuclease VIII-Like 1 3
  • Endonuclease VIII 3
  • EC 4.2.99.18 4
  • EC 3.2.2.- 4
  • HFPG1 3
  • NEI1 3

External Ids for NEIL1 Gene

Previous GeneCards Identifiers for NEIL1 Gene

  • GC15P071517
  • GC15P068730
  • GC15P073215
  • GC15P073355
  • GC15P073426
  • GC15P075639
  • GC15P052397

Summaries for NEIL1 Gene

Entrez Gene Summary for NEIL1 Gene

  • This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for NEIL1 Gene

NEIL1 (Nei Like DNA Glycosylase 1) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include nucleic acid binding and damaged DNA binding.

UniProtKB/Swiss-Prot for NEIL1 Gene

  • Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for NEIL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL1 Gene

Genomics for NEIL1 Gene

Regulatory Elements for NEIL1 Gene

Promoters for NEIL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEIL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEIL1 Gene

Chromosome:
15
Start:
75,346,649 bp from pter
End:
75,357,114 bp from pter
Size:
10,466 bases
Orientation:
Plus strand

Genomic View for NEIL1 Gene

Genes around NEIL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEIL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL1 Gene

Proteins for NEIL1 Gene

  • Protein details for NEIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FI4-NEIL1_HUMAN
    Recommended name:
    Endonuclease 8-like 1
    Protein Accession:
    Q96FI4
    Secondary Accessions:
    • D3DW75
    • Q6ZRA7
    • Q86XW7
    • Q9H6C3

    Protein attributes for NEIL1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK128372; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEIL1 Gene

neXtProt entry for NEIL1 Gene

Proteomics data for NEIL1 Gene at MOPED

Post-translational modifications for NEIL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NEIL1 Gene

Domains & Families for NEIL1 Gene

Gene Families for NEIL1 Gene

Suggested Antigen Peptide Sequences for NEIL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FI4

UniProtKB/Swiss-Prot:

NEIL1_HUMAN :
  • Belongs to the FPG family.
Family:
  • Belongs to the FPG family.
genes like me logo Genes that share domains with NEIL1: view

Function for NEIL1 Gene

Molecular function for NEIL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Removes damaged bases from DNA, leaving an abasic site.
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
UniProtKB/Swiss-Prot Induction:
Up-regulated during S-phase.

Enzyme Numbers (IUBMB) for NEIL1 Gene

Gene Ontology (GO) - Molecular Function for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA,TAS --
GO:0008022 protein C-terminus binding IPI 17611195
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with NEIL1: view
genes like me logo Genes that share phenotypes with NEIL1: view

Animal Models for NEIL1 Gene

MGI Knock Outs for NEIL1:

Animal Model Products

miRNA for NEIL1 Gene

miRTarBase miRNAs that target NEIL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEIL1 Gene

Localization for NEIL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEIL1 Gene COMPARTMENTS Subcellular localization image for NEIL1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with NEIL1: view

Pathways & Interactions for NEIL1 Gene

genes like me logo Genes that share pathways with NEIL1: view

Interacting Proteins for NEIL1 Gene

Gene Ontology (GO) - Biological Process for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair IEA --
GO:0032074 negative regulation of nuclease activity IDA 17611195
GO:0045008 depyrimidination TAS --
genes like me logo Genes that share ontologies with NEIL1: view

No data available for SIGNOR curated interactions for NEIL1 Gene

Drugs & Compounds for NEIL1 Gene

(2) Drugs for NEIL1 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tris(Hydroxymethyl)Aminomethane Experimental Pharma Target 0

(11) Additional Compounds for NEIL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEIL1: view

Transcripts for NEIL1 Gene

Unigene Clusters for NEIL1 Gene

Nei endonuclease VIII-like 1 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^
SP1: - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - -
SP13:
SP14: -
SP15: - - - -
SP16:

ExUns: 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: - -
SP14:
SP15:
SP16:

Relevant External Links for NEIL1 Gene

GeneLoc Exon Structure for
NEIL1
ECgene alternative splicing isoforms for
NEIL1

Expression for NEIL1 Gene

mRNA expression in normal human tissues for NEIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEIL1 Gene

This gene is overexpressed in Plasma (22.9), Blymphocyte (21.9), NK cells (11.1), and Heart (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEIL1 Gene



SOURCE GeneReport for Unigene cluster for NEIL1 Gene Hs.512732

mRNA Expression by UniProt/SwissProt for NEIL1 Gene

Q96FI4-NEIL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NEIL1: view

Protein tissue co-expression partners for NEIL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NEIL1 Gene

Orthologs for NEIL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL1 36
  • 99 (a)
OneToOne
NEIL1 35
  • 99.44 (n)
  • 98.74 (a)
cow
(Bos Taurus)
Mammalia NEIL1 36
  • 89 (a)
OneToOne
NEIL1 35
  • 87.18 (n)
  • 86.41 (a)
dog
(Canis familiaris)
Mammalia NEIL1 35
  • 83.03 (n)
  • 79.18 (a)
NEIL1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neil1 16
Neil1 36
  • 79 (a)
OneToOne
Neil1 35
  • 81.49 (n)
  • 79.69 (a)
oppossum
(Monodelphis domestica)
Mammalia NEIL1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEIL1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neil1 35
  • 81.14 (n)
  • 79.59 (a)
chicken
(Gallus gallus)
Aves NEIL1 35
  • 63.93 (n)
  • 59.27 (a)
NEIL1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neil1 35
  • 61.75 (n)
  • 62.46 (a)
Str.3112 35
zebrafish
(Danio rerio)
Actinopterygii neil1 36
  • 42 (a)
OneToOne
neil1 35
  • 60.63 (n)
  • 60.63 (a)
zgc56361 35
Species with no ortholog for NEIL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL1 Gene

ENSEMBL:
Gene Tree for NEIL1 (if available)
TreeFam:
Gene Tree for NEIL1 (if available)

Paralogs for NEIL1 Gene

No data available for Paralogs for NEIL1 Gene

Variants for NEIL1 Gene

Sequence variations from dbSNP and Humsavar for NEIL1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs5745905 - 75,349,150(+) CATGT(C/G)CGGCT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs5745906 - 75,349,153(+) GTCCG(A/G)CTCTT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs5745907 - 75,349,311(+) GGCCC(C/T)GTGTC nc-transcript-variant, reference, synonymous-codon, missense
rs7183491 - 75,352,222(+) GAGAT(C/G)CTGTA intron-variant, nc-transcript-variant, reference, missense
VAR_020584 -

Structural Variations from Database of Genomic Variants (DGV) for NEIL1 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
nsv1615 CNV Insertion 18451855

Variation tolerance for NEIL1 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEIL1 Gene

HapMap Linkage Disequilibrium report
NEIL1
Human Gene Mutation Database (HGMD)
NEIL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEIL1 Gene

Disorders for NEIL1 Gene

Relevant External Links for NEIL1

Genetic Association Database (GAD)
NEIL1
Human Genome Epidemiology (HuGE) Navigator
NEIL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEIL1

No disorders were found for NEIL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEIL1 Gene

Publications for NEIL1 Gene

  1. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. (PMID: 11904416) Hazra T.K. … Mitra S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23 67
  2. Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. (PMID: 20005182) Odell I.D. … Pederson D.S. (DNA Repair (Amst.) 2010) 3 23
  3. Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma. (PMID: 19443904) Forsbring M. … Alseth I. (Carcinogenesis 2009) 3 23
  4. Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. (PMID: 18032376) Dou H. … Mitra S. (J. Biol. Chem. 2008) 3 23
  5. Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PMID: 18515411) Dallosso A.R. … Sampson J.R. (Gut 2008) 3 23

Products for NEIL1 Gene

Sources for NEIL1 Gene

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