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Aliases for NEIL1 Gene

Aliases for NEIL1 Gene

  • Nei Endonuclease VIII-Like 1 (E. Coli) 2 3
  • FPG1 3 4 6
  • DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil1 3 4
  • DNA Glycosylase/AP Lyase Neil1 3 4
  • Endonuclease VIII-Like 1 3 4
  • Nei-Like Protein 1 3 4
  • Nei Homolog 1 3 4
  • NEI1 3 6
  • NEH1 3 4
  • Endonuclease 8-Like 1 3
  • Endonuclease VIII 3
  • EC 4.2.99.18 4
  • EC 3.2.2.- 4
  • HFPG1 3

External Ids for NEIL1 Gene

Summaries for NEIL1 Gene

Entrez Gene Summary for NEIL1 Gene

  • This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for NEIL1 Gene

NEIL1 (Nei Endonuclease VIII-Like 1 (E. Coli)) is a Protein Coding gene. Diseases associated with NEIL1 include familial colorectal cancer and sclerosing cholangitis. Among its related pathways are Resolution of Abasic Sites (AP sites). GO annotations related to this gene include protein C-terminus binding and DNA-(apurinic or apyrimidinic site) lyase activity.

UniProtKB/Swiss-Prot for NEIL1 Gene

  • Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for NEIL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEIL1 Gene

Genomics for NEIL1 Gene

Genomic Location for NEIL1 Gene

Start:
75,346,955 bp from pter
End:
75,357,114 bp from pter
Size:
10,160 bases
Orientation:
Plus strand

Genomic View for NEIL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEIL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEIL1 Gene

Regulatory Elements for NEIL1 Gene

Proteins for NEIL1 Gene

  • Protein details for NEIL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FI4-NEIL1_HUMAN
    Recommended name:
    Endonuclease 8-like 1
    Protein Accession:
    Q96FI4
    Secondary Accessions:
    • D3DW75
    • Q6ZRA7
    • Q86XW7
    • Q9H6C3

    Protein attributes for NEIL1 Gene

    Size:
    390 amino acids
    Molecular mass:
    43684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK128372; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEIL1 Gene

neXtProt entry for NEIL1 Gene

Proteomics data for NEIL1 Gene at MOPED

Post-translational modifications for NEIL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEIL1 Gene

Domains for NEIL1 Gene

UniProtKB/Swiss-Prot:

NEIL1_HUMAN
Family:
  • Belongs to the FPG family.:
    • Q96FI4
genes like me logo Genes that share domains with NEIL1: view

No data available for Gene Families for NEIL1 Gene

Function for NEIL1 Gene

Molecular function for NEIL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Removes damaged bases from DNA, leaving an abasic site
UniProtKB/Swiss-Prot CatalyticActivity: The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
UniProtKB/Swiss-Prot Induction: Up-regulated during S-phase.

Enzyme Numbers (IUBMB) for NEIL1 Gene

Gene Ontology (GO) - Molecular Function for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003684 damaged DNA binding IEA --
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA --
GO:0008022 protein C-terminus binding IPI 17611195
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with NEIL1: view
genes like me logo Genes that share phenotypes with NEIL1: view

Animal Models for NEIL1 Gene

MGI Knock Outs for NEIL1:

miRNA for NEIL1 Gene

miRTarBase miRNAs that target NEIL1

No data available for Transcription Factor Targeting and HOMER Transcription for NEIL1 Gene

Localization for NEIL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEIL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEIL1 Gene COMPARTMENTS Subcellular localization image for NEIL1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA 17611195
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with NEIL1: view

Pathways for NEIL1 Gene

SuperPathways for NEIL1 Gene

Superpath Contained pathways
1 Resolution of Abasic Sites (AP sites)
genes like me logo Genes that share pathways with NEIL1: view

Pathways by source for NEIL1 Gene

1 KEGG pathway for NEIL1 Gene

Interacting Proteins for NEIL1 Gene

Gene Ontology (GO) - Biological Process for NEIL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006281 DNA repair TAS --
GO:0006284 base-excision repair TAS --
GO:0006285 base-excision repair, AP site formation TAS --
GO:0006289 nucleotide-excision repair IEA --
genes like me logo Genes that share ontologies with NEIL1: view

Compounds for NEIL1 Gene

(1) Drugbank Compounds for NEIL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Tris(Hydroxymethyl)Aminomethane
target

(12) Novoseek inferred chemical compound relationships for NEIL1 Gene

Compound -log(P) Hits PubMed IDs
2,6-diamino-4-hydroxy-5-formamidopyrimidine 90.5 1
fapy 90.1 3
5-hydroxyuracil 89.9 3
dihydrouracil 88.5 4
thymine glycol 88.4 1
genes like me logo Genes that share compounds with NEIL1: view

Transcripts for NEIL1 Gene

Unigene Clusters for NEIL1 Gene

Nei endonuclease VIII-like 1 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEIL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^
SP1: - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - -
SP13:
SP14: -
SP15: - - - -
SP16:

ExUns: 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13: - -
SP14:
SP15:
SP16:

Relevant External Links for NEIL1 Gene

GeneLoc Exon Structure for
NEIL1
ECgene alternative splicing isoforms for
NEIL1

Expression for NEIL1 Gene

mRNA expression in normal human tissues for NEIL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEIL1 Gene

SOURCE GeneReport for Unigene cluster for NEIL1 Gene Hs.512732

mRNA Expression by UniProt/SwissProt for NEIL1 Gene

Q96FI4-NEIL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with NEIL1: view

Orthologs for NEIL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NEIL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEIL1 36
  • 99.44 (n)
  • 98.74 (a)
NEIL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEIL1 36
  • 87.18 (n)
  • 86.41 (a)
NEIL1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEIL1 36
  • 83.03 (n)
  • 79.18 (a)
NEIL1 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Neil1 36
  • 81.49 (n)
  • 79.69 (a)
Neil1 16
Neil1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEIL1 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEIL1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Neil1 36
  • 81.14 (n)
  • 79.59 (a)
chicken
(Gallus gallus)
Aves NEIL1 36
  • 63.93 (n)
  • 59.27 (a)
NEIL1 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia neil1 36
  • 61.75 (n)
  • 62.46 (a)
Str.3112 36
zebrafish
(Danio rerio)
Actinopterygii neil1 36
  • 60.63 (n)
  • 60.63 (a)
neil1 37
  • 42 (a)
OneToOne
zgc56361 36
Species with no ortholog for NEIL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEIL1 Gene

ENSEMBL:
Gene Tree for NEIL1 (if available)
TreeFam:
Gene Tree for NEIL1 (if available)

Paralogs for NEIL1 Gene

No data available for Paralogs for NEIL1 Gene

Variants for NEIL1 Gene

Sequence variations from dbSNP and Humsavar for NEIL1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs5745902 -- 75,346,878(+) ctccc(A/G)aggcc upstream-variant-2KB
rs5745903 -- 75,347,140(+) TTGTT(G/T)TTGTT upstream-variant-2KB, utr-variant-5-prime, intron-variant, nc-transcript-variant
rs5745904 -- 75,347,414(+) CTGCC(C/T)CCGCA upstream-variant-2KB, utr-variant-5-prime, nc-transcript-variant
rs5745905 - 75,349,150(+) CATGT(C/G)CGGCT reference, missense, nc-transcript-variant
rs5745906 - 75,349,153(+) GTCCG(A/G)CTCTT missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NEIL1 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
nsv1615 CNV Insertion 18451855

Relevant External Links for NEIL1 Gene

HapMap Linkage Disequilibrium report
NEIL1
Human Gene Mutation Database (HGMD)
NEIL1

Disorders for NEIL1 Gene

(1) Novoseek inferred disease relationships for NEIL1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 3

Relevant External Links for NEIL1

Genetic Association Database (GAD)
NEIL1
Human Genome Epidemiology (HuGE) Navigator
NEIL1
genes like me logo Genes that share disorders with NEIL1: view

No data available for UniProtKB/Swiss-Prot for NEIL1 Gene

Publications for NEIL1 Gene

  1. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. (PMID: 11904416) Hazra T.K. … Mitra S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. (PMID: 12509226) Bandaru V. … Bond J.P. (DNA Repair 2002) 3 4 23
  3. The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. (PMID: 15232006) Doublie S. … Wallace S.S. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PMID: 14522990) Dou H. … Hazra T.K. (J. Biol. Chem. 2003) 3 4 23
  5. OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study. (PMID: 18155253) Hatt L. … Vogel U. (Mutat. Res. 2008) 3 23 49

Products for NEIL1 Gene

Sources for NEIL1 Gene

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