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NEIL1 Gene

protein-coding GIFtS: 57

GC15P073426

nei endonuclease VIII-like 1 (E. coli)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.2.2.-,EC 4.2.99.18 ^³
FLJ22402 ^¹, ²
FPG1 ^¹, ², ³
NEH1 ^³
NEI1 ^¹, ²
hFPG1 ^¹, ²

Descriptions
DNA glycosylase/AP lyase Neil1 ^³
DNA-(apurinic or apyrimidinic site) lyase Neil1 ^³
Nei-like 1 ^³
endonuclease VIII ^²
nei endonuclease VIII-like 1 ^²
nei endonuclease VIII-like 1 (E. coli) ^²

External Ids
HGNC: 18448¹
Entrez Gene: 79661²
UniProtKB: Q96FI4³
Ensembl: ENSG00000140398⁷

Search outside databases for aliases for NEIL1 gene

Previous GC identifers: GC15P071517 GC15P068730 GC15P073215 GC15P073355

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NEIL1:

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These

glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive

oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et

al., 2002 [PubMed 12509226]).[supplied by OMIM]

UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4

Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts

as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized

pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal

activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks

in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand

break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase

activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches

Gene Wiki entry for NEIL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NEIL1 gene

Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q33.33

NEIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P073426: (about GC identifiers)

Start:	73,426,463 bp from pter
End:	73,434,641 bp from pter
Size:	8,179 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4 (See protein sequence)

Recommended Name: Endonuclease VIII-like 1

Size: 390 amino acids; 43684 Da

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1TDH (3D)

Secondary accessions: Q6ZRA7 Q86XW7 Q9H6C3

Alternative splicing: 2 isoforms: Q96FI4-1 Q96FI4-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_078884.2

ENSEMBL proteins:

ENSP00000338328 ENSP00000347170

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NEIL1)
	Human Recombinant Proteins from Abnova (NEIL1)

OriGene Purified Recombinant Human Protein: NEIL1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17611195
GO:0005737	cytoplasm	IDA	17611195

About this table

Antibodies for NEIL1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NEIL1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NEIL1)
	Novus Biologicals Antibodies for NEIL1

Assays for NEIL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96FI4

ProtoNet protein and cluster: Q96FI4

UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4

Similarity: Belongs to the FPG family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NEIL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NEIL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024608

Applied Biosystems Silencer® siRNAs for NEIL1

Sigma-Aldrich siRNA and siRNA Panels for NEIL1

Sigma-Aldrich shRNA for NEIL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NEIL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024608
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024608
untagged cDNA clones in CMV expression vector (see all 2): BC010876

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC010876

UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4

Function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts

as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized

pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal

activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks

in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand

break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase

activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches

Catalytic activity: Removes damaged bases from DNA, leaving an abasic site

Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a

beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal

5'-phosphate

Induction: Up-regulated during S-phase

Enzyme Number (IUBMB): EC 3.2.2.-,EC

10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Neil1):

adipose tissue	growth/size	homeostasis/metabolism	immune system	liver/biliary system
renal/urinary system	reproductive system	skeleton	skin/coat/nails	tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003684	damaged DNA binding	IEA	--
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity	IEA	--
GO:0008022	protein C-terminus binding	IPI	17611195
GO:0008270	zinc ion binding	IEA	--
GO:0016829	lyase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NEIL1

5/13 Interacting proteins for NEIL1 (ENSP00000347170³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NTHL1	ENSP00000219066³	STRING (score=.94)
OGG1	ENSP00000306561³	STRING (score=.928)
NEIL3	ENSP00000264596³	STRING (score=.916)
POLB	ENSP00000265421³	STRING (score=.912)
PCNA	ENSP00000368438³	STRING (score=.896)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006284	base-excision repair	IDA	17611195
GO:0006289	nucleotide-excision repair	IEA	--
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0006979	response to oxidative stress	IDA	17611195
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NEIL1
10/12 Novoseek chemical compound relationships for NEIL1 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
5-hydroxyuracil	91.03	3	18662981 (1), 18032376 (1), 14522990 (1)
dihydrouracil	87.90	8	15907775 (4)
fapygua	87.79	1	15595846 (1)
thymine glycol	86.35	1	15319300 (1)
8-oxoguanine	85.45	2	15350146 (1), 14522990 (1)
fapy	83.66	2	8734295 (1), 15595846 (1)
phosphonate	60.02	3	16982218 (1), 15260972 (1), 17715144 (1)
polynucleotide	53.30	1	16982218 (1)
cytosine	43.63	1	14522990 (1)
oligonucleotide	28.18	1	15319300 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NEIL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NEIL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024608

Sigma-Aldrich siRNA and siRNA Panels for NEIL1

Sigma-Aldrich shRNA for NEIL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024608

REFSEQ mRNAs for NEIL1 gene:

NM_024608.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024608

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024608
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024608
                                 untagged cDNA clones in CMV expression vector (see all 2): BC010876

Additional cDNA sequence:

AB079068.1 AK026055.1 AK026216.1 AK097008.1 BC010876.1

24/25 DOTS entries (see all 25 ):

DT.214283 DT.75186708 DT.101984918 DT.100780758 DT.97858864 DT.87017892 DT.100834116 DT.95310279

DT.121052950 DT.100780754 DT.40195464 DT.40222964 DT.121052741 DT.121052678 DT.121052827 DT.91758164

DT.91818435 DT.95169184 DT.121052819 DT.91758166 DT.95169179 DT.97775012 DT.100670599 DT.100682869

24/122 AceView cDNA sequences (see all 122 ):

AI865117 BI908874 AI913135 AI393566 AW575225 AA370630 BQ028738 BM678088

AA731925 CA944521 CA442550 AI816136 BQ028756 AK097008 AI638424 AI816095

BI916872 CD722353 AI925612 AA830735 AI373305 AW444910 BF058910 AI290102

highest scoring ESTs for NEIL1:

AA744383 AA280803 AA595778 AA604501 AA668993 AA724197 AA731925 AA824509 AA831660 AA832090

Unigene Cluster for NEIL1:

Nei endonuclease VIII-like 1 (E. coli)

Hs.512732 [show with all ESTs]

Unigene Representative Sequence: AK097008

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NEIL1 (see all 16 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	^
SP1:																															-		-				-
SP2:																																	-		-		-
SP3:																	-		-		-		-		-								-		-		-
SP4:																	-		-		-		-		-						-		-		-		-
SP5:																	-		-		-		-		-		-		-		-		-		-		-

ExUns:	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16
SP1:	-		-										-						-
SP2:	-		-										-						-
SP3:
SP4:
SP5:	-		-

About this scheme

ECgene alternative splicing isoforms for NEIL1

2 Ensembl transcripts including schematic representations:

ENST00000336572 ENST00000355059

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NEIL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NEIL1

¹ / ² / ³

5 probe-sets matching NEIL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44133_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA744383	1.00	1.00	1.00	1
219396_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024608	0.60	1.00	0.82	1
241477_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BF194999	0.40	1.00	0.76	1
219396_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241477_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGAAAAATGC

SOURCE GeneReport for Unigene cluster: Hs.512732
UniProtKB/Swiss-Prot: NEIL1_HUMAN, Q96FI4
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NEIL1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NEIL1¹	--	nei endonuclease VIII-like 1 (E. coli)	82.78(n) 78.66(a)	611615 XM_849302.1 XP_854395.1
chimpanzee (Pan troglodytes)	NEIL1¹	--	nei endonuclease VIII-like 1 (E. coli)	97.86(n) 96.67(a)	467829 XM_001144152.1 XP_001144152.1
cow (Bos taurus)	NEIL1¹	--	nei endonuclease VIII-like 1 (E. coli)	88.69(n) 89.3(a)	513458 NM_001014917.1 NP_001014917.1
rat (Rattus norvegicus)	Neil1¹	--	nei endonuclease VIII-like 1 (E. coli)	80.88(n) 79.07(a)	367090 NM_001025754.1 NP_001020925.1
mouse (Mus musculus)	Neil1^{1, 5}	9⁵	nei endonuclease VIII-like 1 (E. coli)^{1, 5}	81.23(n)¹ 79.18(a)¹	72774¹ NM_028347.2¹ NP_082623.1¹ AA637676⁵ AB079069⁵ (see all 12)

About this table Species with no ortholog for NEIL1

ENSEMBL Gene Tree for NEIL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/69 NCBI SNPs in NEIL1 are shown (see all 69 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs5745926^1,2	C,F,H	73433168(+)	`AGGAGG/AACTTT`	1	N/D	mis¹ ese³ trp³		12	NS EU EA WA NA	1144
--	rs5745905^1,2	H	73428544(+)	`CATGTC/GCGGCT`	1	S/C	mis¹ ese³		5	NS EU EA WA	574
	rs4555122^1,2	H	73434465(+)	`TCTTAT/GTGTCT`	1	--	ut3¹		4	EU EA WA	406
	rs7183491^1,2	H	73431616(+)	`GAGATC/GCTGTA`	1	I/M	mis¹ ese³		4	EU EA WA	394
--	rs7182283^1,2	A,C,F,H	73430812(+)	`ccacaG/Tgagtg`	1	--	int¹		8	EU EA WA	800
--	rs5745920^1,2	A,C,F	73432403(+)	`ggtggC/Tgggca`	1	--	int¹		1	NS	158
	rs11630521^1,2	A,C,H	73432591(+)	`ACAGGC/TAGGAC`	1	--	int¹		4	EU EA WA	418
	rs5745915^1,2	C,F,H	73430063(+)	`CCCCTG/ATGTGA`	1	--	int¹		11	NS EU EA WA	1232
	rs5745911^1,2	F,H	73429432(+)	`GGAGGG/AGACTA`	1	--	int¹ trp³		5	NS EU EA WA	588
	rs5745912^1,2	F,H	73429499(+)	`GTATTC/GTGTGT`	1	--	int¹		5	NS EU EA WA	514

About this table

HapMap Linkage Disequilibrium images for NEIL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608844

1 Novoseek disease relationship for NEIL1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	1	18594018 (1)

About this table

Human Gene Mutation Database: NEIL1
Human Genome Epidemiology Navigator: NEIL1 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/55 PubMed articles for NEIL1 gene (see all 55 ):

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. (PubMed id 11904416)^{1, 2, 3, 4} Hazra T.K.... Mitra S. (2002)
The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. (PubMed id 15232006)^{1, 3, 4} Doublie S.... Wallace S.S. (2004)
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. (PubMed id 14522990)^{1, 3, 4} Dou H.... Hazra T.K. (2003)
A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. (PubMed id 12509226)^{1, 3, 4} Bandaru V....Bond J.P. (2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. (PubMed id 12200441)^{3, 4} Takao M.... Yasui A. (2002)
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. (PubMed id 18662981)^{1, 3} Hegde M.L....Mitra S. (2008)
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. (PubMed id 18032376)^{1, 3} Dou H....Mitra S. (2008)
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. (PubMed id 17611195)^{1, 3} Das A....Bohr V.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79661	HGNC: 18448	AceView: NEIL1	Ensembl:ENSG00000140398	euGenes: HUgn79661
ECgene: NEIL1	H-InvDB: NEIL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NEIL1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/neil1/

Licensable Technologies for NEIL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NEIL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NEIL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NEIL1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NEIL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
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	Recombinant Proteins (NEIL1)
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	Recombinant Proteins (NEIL1)
	Antibodies (NEIL1)

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Antibodies for NEIL1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NEIL1 Gene at Home site.
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NEIL1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for NEIL1

Summaries
for NEIL1

Genomic Location
for NEIL1

Proteins
for NEIL1

Protein Domains/
Families
for NEIL1

Gene Function
for NEIL1

Pathways & Interactions
for NEIL1

Drugs & Compounds
for NEIL1

Transcripts
for NEIL1

Expression
for NEIL1

Orthologs
for NEIL1

Paralogs
for NEIL1

SNPs/Variants
for NEIL1

Disorders & Mutations
for NEIL1

Medical News
for NEIL1

Publications
for NEIL1

Search for NEIL1

Genome Databases showing NEIL1

Other Databases showing NEIL1

Specialized Databases showing NEIL1

Licensable Technologies
for NEIL1

Services
for NEIL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NEIL1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor NEIL1

Summariesfor NEIL1

Genomic Locationfor NEIL1

Proteinsfor NEIL1

Protein Domains/Familiesfor NEIL1

Gene Functionfor NEIL1

Pathways & Interactionsfor NEIL1

Drugs & Compoundsfor NEIL1

Transcriptsfor NEIL1

Expression for NEIL1

Orthologsfor NEIL1

Paralogsfor NEIL1

SNPs/Variantsfor NEIL1

Disorders & Mutationsfor NEIL1

Medical Newsfor NEIL1

Publicationsfor NEIL1

Search for NEIL1

Genome Databases showing NEIL1

Other Databases showing NEIL1

Specialized Databases showing NEIL1

Licensable Technologiesfor NEIL1

Servicesfor NEIL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NEIL1

Summaries
for NEIL1

Genomic Location
for NEIL1

Proteins
for NEIL1

Protein Domains/
Families
for NEIL1

Gene Function
for NEIL1

Pathways & Interactions
for NEIL1

Drugs & Compounds
for NEIL1

Transcripts
for NEIL1

Expression
for NEIL1

Orthologs
for NEIL1

Paralogs
for NEIL1

SNPs/Variants
for NEIL1

Disorders & Mutations
for NEIL1

Medical News
for NEIL1

Publications
for NEIL1

Licensable Technologies
for NEIL1

Services
for NEIL1