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Aliases for NEGR1 Gene

Aliases for NEGR1 Gene

  • Neuronal Growth Regulator 1 2 3 5
  • IgLON Family Member 4 2 3 4
  • A Kindred Of IgLON 2 3
  • Neurotractin 2 3
  • IGLON4 3 4
  • DMML2433 3
  • KILON 3
  • Ntra 3

External Ids for NEGR1 Gene

Previous GeneCards Identifiers for NEGR1 Gene

  • GC01M071253
  • GC01M071238
  • GC01M071580
  • GC01M071641
  • GC01M071868
  • GC01M069978

Summaries for NEGR1 Gene

GeneCards Summary for NEGR1 Gene

NEGR1 (Neuronal Growth Regulator 1) is a Protein Coding gene. Diseases associated with NEGR1 include Podoconiosis. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. An important paralog of this gene is LSAMP.

UniProtKB/Swiss-Prot for NEGR1 Gene

  • May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Gene Wiki entry for NEGR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEGR1 Gene

Genomics for NEGR1 Gene

Regulatory Elements for NEGR1 Gene

Enhancers for NEGR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G072280 1.6 FANTOM5 ENCODE dbSUPER 12.8 -1.1 -1129 6.1 PKNOX1 DMAP1 GATA2 CBX5 FOS JUNB ZNF610 ZNF585B RFX3 GLIS1 RPL31P12 NEGR1 LOC105378797
GH01G072220 0.3 FANTOM5 1.6 +62.0 61977 0.1 NEGR1 GC01P072172 GDI2P2
GH01G072281 0.4 Ensembl 0.7 +2.6 2647 0.4 EP300 RPL31P12 NEGR1 GDI2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEGR1 on UCSC Golden Path with GeneCards custom track

Promoters for NEGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008531 -553 4001 PKNOX1 DMAP1 GATA2 CBX5 FOS JUNB ZNF610 ZNF585B RFX3 GLIS1
ENSR00000252472 1747 201 CTCF MXI1 PRDM1

Genomic Location for NEGR1 Gene

71,395,940 bp from pter
72,282,847 bp from pter
886,908 bases
Minus strand

Genomic View for NEGR1 Gene

Genes around NEGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEGR1 Gene

Proteins for NEGR1 Gene

  • Protein details for NEGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal growth regulator 1
    Protein Accession:
    Secondary Accessions:
    • Q5VT21
    • Q6UY06
    • Q8N440
    • Q8NAQ3

    Protein attributes for NEGR1 Gene

    354 amino acids
    Molecular mass:
    38719 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88499.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NEGR1 Gene


neXtProt entry for NEGR1 Gene

Post-translational modifications for NEGR1 Gene

  • Glycosylation at posLast=7373, posLast=155155, Asn275, posLast=286286, Asn294, and Asn307
  • Modification sites at PhosphoSitePlus

Other Protein References for NEGR1 Gene

Antibody Products

  • Abcam antibodies for NEGR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NEGR1

No data available for DME Specific Peptides for NEGR1 Gene

Domains & Families for NEGR1 Gene

Suggested Antigen Peptide Sequences for NEGR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with NEGR1: view

Function for NEGR1 Gene

Molecular function for NEGR1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Gene Ontology (GO) - Molecular Function for NEGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with NEGR1: view
genes like me logo Genes that share phenotypes with NEGR1: view

Animal Models for NEGR1 Gene

MGI Knock Outs for NEGR1:

Animal Model Products

CRISPR Products

miRNA for NEGR1 Gene

miRTarBase miRNAs that target NEGR1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEGR1 Gene

Localization for NEGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEGR1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEGR1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NEGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NEGR1: view

Pathways & Interactions for NEGR1 Gene

genes like me logo Genes that share pathways with NEGR1: view

Gene Ontology (GO) - Biological Process for NEGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007155 cell adhesion IEA --
GO:0007626 locomotory behavior IEA --
GO:0007631 feeding behavior IEA --
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with NEGR1: view

No data available for SIGNOR curated interactions for NEGR1 Gene

Drugs & Compounds for NEGR1 Gene

No Compound Related Data Available

Transcripts for NEGR1 Gene

Unigene Clusters for NEGR1 Gene

Neuronal growth regulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEGR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: - -
SP3: -

Relevant External Links for NEGR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEGR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEGR1 Gene

This gene is overexpressed in Cerebrospinal fluid (13.1) and Frontal cortex (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEGR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NEGR1 Gene:


SOURCE GeneReport for Unigene cluster for NEGR1 Gene:


Evidence on tissue expression from TISSUES for NEGR1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NEGR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEGR1 Gene

Orthologs for NEGR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEGR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEGR1 35 34
  • 99.72 (n)
(Bos Taurus)
Mammalia NEGR1 34
  • 95.86 (n)
(Canis familiaris)
Mammalia NEGR1 35 34
  • 95.39 (n)
(Rattus norvegicus)
Mammalia Negr1 34
  • 89.37 (n)
(Mus musculus)
Mammalia Negr1 16 35 34
  • 88.22 (n)
(Monodelphis domestica)
Mammalia NEGR1 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia NEGR1 35
  • 83 (a)
(Gallus gallus)
Aves NEGR1 35 34
  • 79.92 (n)
(Anolis carolinensis)
Reptilia NEGR1 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia negr1 34
  • 79.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2002 34
(Danio rerio)
Actinopterygii negr1 35 34
  • 66.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lac 35 34
  • 47.7 (n)
CG11320 35
  • 26 (a)
Ama 35
  • 25 (a)
CG14010 35
  • 22 (a)
CG14521 35
  • 22 (a)
CG40378 35
  • 20 (a)
CG42368 35
  • 19 (a)
CG34391 35
  • 18 (a)
CG7166 35
  • 18 (a)
CG31708 35
  • 17 (a)
CG34353 35
  • 16 (a)
CG42343 35
  • 16 (a)
wrapper 35
  • 16 (a)
CG31646 35
  • 16 (a)
CG32791 35
  • 15 (a)
klg 35
  • 15 (a)
CG31814 35
  • 13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007500 34
  • 43.73 (n)
(Caenorhabditis elegans)
Secernentea rig-5 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for NEGR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEGR1 Gene

Gene Tree for NEGR1 (if available)
Gene Tree for NEGR1 (if available)

Paralogs for NEGR1 Gene

Paralogs for NEGR1 Gene

(7) SIMAP similar genes for NEGR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NEGR1: view

Variants for NEGR1 Gene

Sequence variations from dbSNP and Humsavar for NEGR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000001828 -- 71,449,678(+) ATCAC(A/T)TAATT intron-variant
rs1000007675 -- 72,197,572(+) TAGAA(C/T)TATAA intron-variant
rs1000008985 -- 71,956,209(+) ATTTC(C/T)TTGAT intron-variant
rs1000011952 -- 71,499,617(+) TATAA(A/T)CCCAT intron-variant
rs1000014288 -- 71,744,603(+) TTTTC(C/T)GATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEGR1 Gene

Variant ID Type Subtype PubMed ID
dgv11n111 CNV deletion 26073780
dgv178n100 CNV loss 25217958
dgv179n100 CNV loss 25217958
dgv180n100 CNV loss 25217958
dgv181n100 CNV gain 25217958
dgv182n100 CNV gain 25217958
dgv183n100 CNV gain 25217958
dgv19n27 CNV gain 19166990
dgv25e214 CNV loss 21293372
dgv309n54 CNV loss 21841781
dgv310n54 CNV loss 21841781
dgv311n54 CNV loss 21841781
dgv312n54 CNV loss 21841781
dgv45e212 CNV loss 25503493
dgv50n67 CNV gain 20364138
esv1009711 CNV insertion 20482838
esv1246885 CNV insertion 17803354
esv1377110 CNV insertion 17803354
esv2459000 CNV insertion 19546169
esv2528141 CNV insertion 19546169
esv2595732 CNV insertion 19546169
esv2609491 CNV deletion 19546169
esv2660119 CNV deletion 23128226
esv2662443 CNV deletion 23128226
esv2663666 CNV deletion 23128226
esv2671566 CNV deletion 23128226
esv2673031 CNV deletion 23128226
esv27109 CNV gain 19812545
esv2749719 CNV deletion 23290073
esv2749730 CNV deletion 23290073
esv2749741 CNV deletion 23290073
esv2749752 CNV deletion 23290073
esv2749763 CNV deletion 23290073
esv2749774 CNV deletion 23290073
esv275261 CNV loss 21479260
esv2758939 CNV gain+loss 17122850
esv2762150 CNV loss 21179565
esv2763317 CNV loss 21179565
esv2763318 CNV loss 21179565
esv2764234 CNV gain+loss 21179565
esv3304727 CNV mobile element insertion 20981092
esv3309645 CNV mobile element insertion 20981092
esv33679 CNV gain 17666407
esv3443181 CNV insertion 20981092
esv3563859 CNV deletion 23714750
esv3586384 CNV loss 21293372
esv3586386 CNV gain 21293372
esv3586390 CNV loss 21293372
esv3586393 CNV loss 21293372
esv3586394 CNV loss 21293372
esv3586396 CNV loss 21293372
esv3586397 CNV loss 21293372
esv3586399 CNV loss 21293372
esv3586400 CNV gain 21293372
esv3586401 CNV loss 21293372
esv3586402 CNV loss 21293372
esv3586403 CNV loss 21293372
esv3586407 CNV loss 21293372
esv3893668 CNV loss 25118596
esv3893679 CNV loss 25118596
esv4720 CNV loss 18987735
esv8759 CNV loss 19470904
esv992761 CNV loss 20482838
nsv1001732 CNV loss 25217958
nsv1003527 CNV loss 25217958
nsv1008210 CNV loss 25217958
nsv1013256 CNV loss 25217958
nsv1120192 CNV tandem duplication 24896259
nsv1122361 CNV deletion 24896259
nsv1133866 CNV deletion 24896259
nsv1144384 CNV deletion 24896259
nsv1146835 CNV insertion 26484159
nsv1354 CNV deletion 18451855
nsv1365 CNV deletion 18451855
nsv1376 CNV deletion 18451855
nsv254 CNV deletion 15895083
nsv428454 CNV loss 18775914
nsv461895 CNV loss 19166990
nsv461951 CNV loss 19166990
nsv470715 CNV gain 18288195
nsv474891 CNV novel sequence insertion 20440878
nsv508016 OTHER sequence alteration 20534489
nsv508017 OTHER sequence alteration 20534489
nsv512743 CNV insertion 21212237
nsv516389 CNV loss 19592680
nsv526840 CNV gain 19592680
nsv528210 CNV loss 19592680
nsv546474 CNV gain 21841781
nsv546475 CNV gain 21841781
nsv546478 CNV loss 21841781
nsv546479 CNV loss 21841781
nsv818223 CNV gain 17921354
nsv821519 CNV deletion 20802225
nsv830159 CNV gain 17160897
nsv830170 CNV gain 17160897
nsv830181 CNV gain 17160897
nsv830192 CNV gain 17160897
nsv945996 CNV duplication 23825009
nsv958058 CNV deletion 24416366
nsv997768 CNV loss 25217958

Variation tolerance for NEGR1 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEGR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEGR1 Gene

Disorders for NEGR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEGR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • podoconiosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NEGR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEGR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NEGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEGR1 Gene

Publications for NEGR1 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 22 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. (PMID: 20386550) Holzapfel C. … Heid I.M. (Int J Obes (Lond) 2010) 3 46 64
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for NEGR1 Gene

Sources for NEGR1 Gene

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