Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NEGR1 Gene

Aliases for NEGR1 Gene

  • Neuronal Growth Regulator 1 2 3 5
  • IgLON Family Member 4 2 3 4
  • A Kindred Of IgLON 2 3
  • Neurotractin 2 3
  • IGLON4 3 4
  • DMML2433 3
  • KILON 3
  • Ntra 3

External Ids for NEGR1 Gene

Previous GeneCards Identifiers for NEGR1 Gene

  • GC01M071253
  • GC01M071238
  • GC01M071580
  • GC01M071641
  • GC01M071868
  • GC01M069978

Summaries for NEGR1 Gene

GeneCards Summary for NEGR1 Gene

NEGR1 (Neuronal Growth Regulator 1) is a Protein Coding gene. Diseases associated with NEGR1 include Podoconiosis. Among its related pathways are Cell adhesion molecules (CAMs). An important paralog of this gene is LSAMP.

UniProtKB/Swiss-Prot for NEGR1 Gene

  • May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).

Gene Wiki entry for NEGR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEGR1 Gene

Genomics for NEGR1 Gene

Regulatory Elements for NEGR1 Gene

Enhancers for NEGR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NEGR1 on UCSC Golden Path with GeneCards custom track

Promoters for NEGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEGR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEGR1 Gene

71,395,940 bp from pter
72,282,847 bp from pter
886,908 bases
Minus strand

Genomic View for NEGR1 Gene

Genes around NEGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEGR1 Gene

Proteins for NEGR1 Gene

  • Protein details for NEGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal growth regulator 1
    Protein Accession:
    Secondary Accessions:
    • Q5VT21
    • Q6UY06
    • Q8N440
    • Q8NAQ3

    Protein attributes for NEGR1 Gene

    354 amino acids
    Molecular mass:
    38719 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88499.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NEGR1 Gene


neXtProt entry for NEGR1 Gene

Proteomics data for NEGR1 Gene at MOPED

Post-translational modifications for NEGR1 Gene

  • Glycosylation at Asn 73, Asn 155, Asn 275, Asn 286, Asn 294, and Asn 307
  • Modification sites at PhosphoSitePlus

Other Protein References for NEGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NEGR1

No data available for DME Specific Peptides for NEGR1 Gene

Domains & Families for NEGR1 Gene

Suggested Antigen Peptide Sequences for NEGR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with NEGR1: view

Function for NEGR1 Gene

Molecular function for NEGR1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
genes like me logo Genes that share phenotypes with NEGR1: view

Animal Models for NEGR1 Gene

MGI Knock Outs for NEGR1:

Animal Model Products

miRNA for NEGR1 Gene

miRTarBase miRNAs that target NEGR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NEGR1 Gene

Localization for NEGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEGR1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for NEGR1 Gene COMPARTMENTS Subcellular localization image for NEGR1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
cytosol 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NEGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NEGR1: view

Pathways & Interactions for NEGR1 Gene

SuperPathways for NEGR1 Gene

genes like me logo Genes that share pathways with NEGR1: view

Pathways by source for NEGR1 Gene

1 KEGG pathway for NEGR1 Gene

Gene Ontology (GO) - Biological Process for NEGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007631 feeding behavior IEA --
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with NEGR1: view

No data available for SIGNOR curated interactions for NEGR1 Gene

Drugs & Compounds for NEGR1 Gene

No Compound Related Data Available

Transcripts for NEGR1 Gene

mRNA/cDNA for NEGR1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NEGR1 Gene

Neuronal growth regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEGR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: - -
SP3: -

Relevant External Links for NEGR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEGR1 Gene

mRNA expression in normal human tissues for NEGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEGR1 Gene

This gene is overexpressed in Cerebrospinal fluid (13.1) and Frontal cortex (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NEGR1 Gene

SOURCE GeneReport for Unigene cluster for NEGR1 Gene Hs.146542

genes like me logo Genes that share expression patterns with NEGR1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NEGR1 Gene

Orthologs for NEGR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEGR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NEGR1 35
  • 95.86 (n)
  • 97.74 (a)
(Canis familiaris)
Mammalia NEGR1 35
  • 95.39 (n)
  • 98.59 (a)
NEGR1 36
  • 73 (a)
(Mus musculus)
Mammalia Negr1 35
  • 88.22 (n)
  • 95.11 (a)
Negr1 16
Negr1 36
  • 96 (a)
(Pan troglodytes)
Mammalia NEGR1 35
  • 99.72 (n)
  • 100 (a)
NEGR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Negr1 35
  • 89.37 (n)
  • 95.4 (a)
(Monodelphis domestica)
Mammalia NEGR1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia NEGR1 36
  • 83 (a)
(Gallus gallus)
Aves NEGR1 35
  • 79.92 (n)
  • 82.39 (a)
NEGR1 36
  • 86 (a)
(Anolis carolinensis)
Reptilia NEGR1 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia negr1 35
  • 79.76 (n)
  • 82.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2002 35
(Danio rerio)
Actinopterygii negr1 35
  • 66.28 (n)
  • 63.37 (a)
negr1 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007500 35
  • 43.73 (n)
  • 34.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lac 35
  • 47.7 (n)
  • 37.66 (a)
Ama 36
  • 25 (a)
CG11320 36
  • 26 (a)
CG14010 36
  • 22 (a)
CG14521 36
  • 22 (a)
CG31646 36
  • 16 (a)
CG31708 36
  • 17 (a)
CG31814 36
  • 13 (a)
CG32791 36
  • 15 (a)
CG34353 36
  • 16 (a)
CG34391 36
  • 18 (a)
CG40378 36
  • 20 (a)
CG42343 36
  • 16 (a)
CG42368 36
  • 19 (a)
CG7166 36
  • 18 (a)
klg 36
  • 15 (a)
Lac 36
  • 24 (a)
wrapper 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea rig-5 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for NEGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEGR1 Gene

Gene Tree for NEGR1 (if available)
Gene Tree for NEGR1 (if available)

Paralogs for NEGR1 Gene

Paralogs for NEGR1 Gene

(7) SIMAP similar genes for NEGR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NEGR1: view

Variants for NEGR1 Gene

Sequence variations from dbSNP and Humsavar for NEGR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs15559 -- 71,404,403(+) TAATG(A/G)TATAA utr-variant-3-prime
rs189610 -- 71,497,672(+) AATGC(A/C)CAGTT intron-variant
rs474680 -- 71,888,224(-) TATTC(A/G)GCCAT intron-variant
rs478548 -- 71,872,638(-) AACCA(A/T)GTTTT intron-variant
rs479560 -- 71,636,229(+) AATAA(G/T)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEGR1 Gene

Variant ID Type Subtype PubMed ID
nsv830159 CNV Gain 17160897
dgv19n27 CNV Gain 19166990
nsv830170 CNV Gain 17160897
esv2660119 CNV Deletion 23128226
nsv526840 CNV Gain 19592680
esv2749719 CNV Deletion 23290073
esv1009711 CNV Insertion 20482838
esv275261 CNV Loss 21479260
nsv461895 CNV Loss 19166990
nsv871330 CNV Loss 21882294
nsv830181 CNV Gain 17160897
esv2609491 CNV Deletion 19546169
esv2459000 CNV Insertion 19546169
esv1377110 CNV Insertion 17803354
dgv239n71 CNV Loss 21882294
esv2749730 CNV Deletion 23290073
esv992761 CNV Loss 20482838
esv27109 CNV Gain 19812545
esv1246885 CNV Insertion 17803354
nsv512743 CNV Insertion 21212237
nsv508016 CNV Loss 20534489
nsv1354 CNV Loss 18451855
esv4720 CNV Deletion 18987735
dgv50n67 CNV Gain 20364138
nsv821519 CNV Deletion 20802225
esv2749741 CNV Deletion 23290073
esv8759 CNV Loss 19470904
esv2662443 CNV Deletion 23128226
esv2671566 CNV Deletion 23128226
nsv818223 CNV Gain 17921354
esv2663666 CNV Deletion 23128226
nsv428454 CNV Loss 18775914
esv2595732 CNV Insertion 19546169
esv273917 CNV Insertion 20981092
esv269005 CNV Insertion 20981092
esv2673031 CNV Deletion 23128226
dgv240n71 CNV Loss 21882294
nsv470715 CNV Gain 18288195
nsv528210 CNV Loss 19592680
esv2749752 CNV Deletion 23290073
esv2749763 CNV Deletion 23290073
esv2749774 CNV Deletion 23290073
nsv1365 CNV Loss 18451855
nsv830192 CNV Gain 17160897
nsv516389 CNV Loss 19592680
nsv461951 CNV Loss 19166990
esv2528141 CNV Insertion 19546169
nsv508017 CNV Loss 20534489
nsv1376 CNV Loss 18451855
nsv254 CNV Loss 15895083
dgv56e1 CNV Complex 17122850
esv33679 CNV Gain 17666407

Variation tolerance for NEGR1 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEGR1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEGR1 Gene

Disorders for NEGR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NEGR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • podoconiosis, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NEGR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NEGR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NEGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NEGR1 Gene

Publications for NEGR1 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 48 67
  2. Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. (PMID: 10075727) Funatsu N. … Maekawa S. (J. Biol. Chem. 1999) 2 3
  3. Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders. (PMID: 25245582) Gamero-Villarroel C. … Gervasini G. (Pharmacogenomics J. 2015) 3
  4. Obesity gene NEGR1 associated with white matter integrity in healthy young adults. (PMID: 25072390) Dennis E.L. … Thompson P.M. (Neuroimage 2014) 3
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for NEGR1 Gene

Sources for NEGR1 Gene