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NEDD9 Gene

protein-coding   GIFtS: 63
GCID: GC06M011183

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 91 2     Cas-Like Docking2
Cas Scaffolding Protein Family Member 21 2 3     Crk-Associated Substrate Related Protein Cas-L2
CASL2 3 5     Enhancer Of Filamentation 12
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 92 3     Enhancer Of Filamentation 1 P552
Renal Carcinoma Antigen NY-REN-122 3     P130Cas-Related Protein2
CAS-L2 3     CasL3
CASS22 3     NEDD-93
HEF12 5     CRK-Associated Substrate-Related Protein3
Cas-like1     hEF13
CAS22     p1053

External Ids:    HGNC: 77331   Entrez Gene: 47392   Ensembl: ENSG000001118597   OMIM: 6022655   UniProtKB: Q145113   
ORGUL members:         

Export aliases for NEDD9 gene to outside databases

Previous GC identifers: GC00U990223 GC06M011246 GC06M011291


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEDD9 Gene:
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are
adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This
protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell
attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported
to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2012)

GeneCards Summary for NEDD9 Gene:
NEDD9 (neural precursor cell expressed, developmentally down-regulated 9) is a protein-coding gene. Diseases associated with NEDD9 include gastrointestinal stromal tumor, and pancreatic ductal adenocarcinoma. An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery
and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play
an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.
Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the
tyrosine phosphorylated form

Gene Wiki entry for NEDD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEDD9 gene promoter:
         GR   FAC1   GR-beta   GR-alpha   Nkx2-5   STAT5A   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NEDD9 promoter sequence
   Search Chromatin IP Primers for NEDD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25-p24   Ensembl cytogenetic band:  6p24.2   HGNC cytogenetic band: 6p25-p24

NEDD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M011183:  view genomic region     (about GC identifiers)

Start:
11,183,531 bp from pter      End:
11,382,581 bp from pter
Size:
199,051 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511 (See protein sequence)
Recommended Name: Enhancer of filamentation 1  
Size: 834 amino acids; 92861 Da
Subunit: Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2,
E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK),
adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1
1 PDB 3D structure from and Proteopedia for NEDD9:
2L81 (3D)    
Secondary accessions: A8K9G7 A8MSJ9 G5E9Y9 Q5T9R4 Q5XKI0
Alternative splicing: 3 isoforms:  Q14511-1   Q14511-2   Q14511-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD9: NX_Q14511

Explore proteomics data for NEDD9 at MOPED

Post-translational modifications: 

  • Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105
    phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a
    caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected1
  • PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family
    kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine
    residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines
    promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact
    actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine
    phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK
    and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1
    cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor.
    Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms
    and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEDD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135865.1  NP_001257962.1  NP_006394.1  NP_892011.2  

    ENSEMBL proteins: 
     ENSP00000368759   ENSP00000395237   ENSP00000422871   ENSP00000368745   ENSP00000421282  
     ENSP00000380534   ENSP00000424975  

    NEDD9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NEDD9

    NEDD9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD9
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    NEDD9 Assay Products:

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    Cloud-Clone Corp. CLIAs for NEDD9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CASS: Cas scaffolding proteins

    3 InterPro protein domains:
     IPR014928 Serine_rich
     IPR001452 SH3_domain
     IPR021901 CAS_DUF3513

    Graphical View of Domain Structure for InterPro Entry Q14511

    ProtoNet protein and cluster: Q14511

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
    Domain: Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain
    containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2
    domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely
    required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization
    with p130cas
    Domain: The SH3 domain interacts with two proline-rich regions of PTK2/FAK1
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    NEDD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASL_HUMAN, Q14511
    Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
    cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery
    and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play
    an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.
    Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the
    tyrosine phosphorylated form
    Induction: Activated upon induction of cell growth

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11827972
         
    NEDD9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEDD9:
     Stronger migration 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nedd9):
     cellular  hematopoietic system  immune system 

    NEDD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nedd9tm1Miku for NEDD9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEDD9
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEDD9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEDD9

    miRNA
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    miRTarBase miRNAs that target NEDD9:
    hsa-mir-145-5p (MIRT006889), hsa-mir-30c-5p (MIRT047916)

    Block miRNA regulation of human, mouse, rat NEDD9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEDD9 (see all 34):
    hsa-miR-2052 hsa-miR-4328 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-766 hsa-miR-4267 hsa-miR-203 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidNEDD9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NEDD9

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CASL_HUMAN, Q14511: Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm.
    Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently
    localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is
    present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular
    concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly
    cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle
    CASL_HUMAN, Q14511: Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9584194
    GO:0005794Golgi apparatus IEA--
    GO:0005819spindle TAS9584194

    NEDD9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEDD9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1
    2Protein Stability
    Protein Stability
    3B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway
    4Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for NEDD9
        Adhesion
    Protein Stability

    1 BioSystems Pathway for NEDD9
        B Cell Receptor Signaling Pathway




    NEDD9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEDD9
    Interactions:

        GeneGlobe Interaction Network for NEDD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEDD9 (Q145112, 3 ENSP000003687594) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-50137 MINT-50136 MINT-50139 I2D: score=3 STRING: ENSP00000363998
    SMAD3P840222, 3, ENSP000003329734MINT-8394324 I2D: score=4 STRING: ENSP00000332973
    ENSG00000215641P143733I2D: score=1 
    ENSG00000229006P143733I2D: score=1 
    ENSG00000234495P143733I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS11827972
    GO:0007067mitosis IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8668148
    GO:0007229integrin-mediated signaling pathway NAS11827972

    NEDD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEDD9 (CASL)

    1 HMDB Compound for NEDD9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for NEDD9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 71.9 2 7615980 (1), 9232815 (1)
    tyrosine 51.4 45 9497377 (6), 19275884 (4), 9886492 (3), 9548475 (3) (see all 14)
    threonine 22.8 3 8522173 (1), 11297557 (1)
    serine 6.69 3 8522173 (1), 11297557 (1)
    phosphatidylinositol 1.25 4 9886492 (1), 9366405 (1)
    glycogen 0.0648 1 12871932 (1)



    NEDD9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEDD9 gene (4 alternative transcripts): 
    NM_001142393.1  NM_001271033.1  NM_006403.3  NM_182966.3  

    Unigene Cluster for NEDD9:

    Neural precursor cell expressed, developmentally down-regulated 9
    Hs.37982  [show with all ESTs]
    Unigene Representative Sequence: NR_073131
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379446(uc003mzv.2) ENST00000448183(uc010joz.2 uc003mzw.3)
    ENST00000504387 ENST00000505589 ENST00000379433(uc003mzx.3) ENST00000513989
    ENST00000397378 ENST00000508546 ENST00000468612 ENST00000512665 ENST00000504634
    ENST00000459670 ENST00000514660 ENST00000461055 ENST00000508800
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate NEDD9 (see all 34):
    hsa-miR-2052 hsa-miR-4328 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-766 hsa-miR-4267 hsa-miR-203 hsa-miR-3163
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      QuantiTect SYBR Green Assays in human, mouse, rat NEDD9
      QuantiFast Probe-based Assays in human, mouse, rat NEDD9

    Additional mRNA sequence: 

    AJ420493.1 AK124210.1 AK292682.1 BC020686.1 BC040207.1 BC050740.1 BX648041.1 L43821.1 
    NR_073131.1 U64317.1 

    Selected DOTS entries (see all 25):

    DT.116179  DT.99968261  DT.208977  DT.95305057  DT.100791240  DT.100791243  DT.100791235  DT.95305066 
    DT.121391128  DT.100685042  DT.40317109  DT.75151845  DT.40310830  DT.95305061  DT.97763229  DT.100738563 
    DT.121391073  DT.91896798  DT.91979790  DT.92437407  DT.95093967  DT.95305056  DT.100026166  DT.100681502 

    Selected AceView cDNA sequences (see all 279):

    CR617655 BU150121 BQ652817 BM453244 Z42849 AI360799 AA910809 AA370785 
    AA360891 AA349429 BQ643743 N91200 AA369826 BQ721949 BQ646725 BQ647728 
    AA687921 CB215014 BG571963 BC020686 AU132178 AA322558 CB990526 BG026361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NEDD9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -     -                       -     -     -           -                       -                                       
    SP2:                                                                                      -     -     -           -                                       
    SP3:                          -     -     -                 -     -     -     -           -     -     -                                                   
    SP4:                                                        -     -     -     -           -     -     -           -                                       
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NEDD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEDD9 expression in normal human tissues (normalized intensities)      NEDD9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAAGAGG
    NEDD9 Expression
    About this image


    NEDD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Eye (Sensory Organs)
             Retina
    NEDD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEDD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37982

    UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
    Tissue specificity: Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in
    T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and
    in lung tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEDD9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd91 , 5 neural precursor cell expressed, developmentally down-regulated more1, 5 84.75(n)1
    89.32(a)1
      13 (20.43 cM)5
    180031  NM_017464.51  NP_059492.31 
     413099165 
    chicken
    (Gallus gallus)
    Aves NEDD91 neural precursor cell expressed, developmentally down-regulated more 70.18(n)
    68.01(a)
      395736  XM_418946.4  XP_418946.4 
    lizard
    (Anolis carolinensis)
    Reptilia NEDD96
    neural precursor cell expressed, developmentally d...
    66(a)
    1 ↔ 1
    GL343209.1(2897060-2974836)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nedd91 neural precursor cell expressed, developmentally down-regulated more 61.08(n)
    59.15(a)
      100487989  XM_002932666.2  XP_002932712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nedd91 neural precursor cell expressed, developmentally down-regulated more 58.54(n)
    55.66(a)
      768136  NM_001077282.1  NP_001070750.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p130CAS6
    p130CAS
    23(a)
    1 → many
    3L(152884-174517)


    ENSEMBL Gene Tree for NEDD9 (if available)
    TreeFam Gene Tree for NEDD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEDD9 gene
    BCAR12  CASS42  EFS2  
    2 SIMAP similar genes for NEDD9 using alignment to 5 protein entries:     CASL_HUMAN (see all proteins):
    SH3GL2    BCAR1

    NEDD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEDD9 (see all 4287)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417949111,2
    C--11183057(+) TAAATC/TTCAGT 4 -- ds50010--------
    rs1500610861,2
    --11183137(+) TCATTA/CAATAT 4 -- ds50010--------
    rs1910250711,2
    --11183237(+) ATATTA/GTGAAA 4 -- ds50010--------
    rs1453825201,2
    --11183238(+) TATTAC/TGAAAA 4 -- ds50010--------
    rs1835046841,2
    --11183298(+) GTCTTG/TTTCCA 4 -- ds50010--------
    rs1163906871,2
    C,F--11183344(+) ATTTTC/TTTTGA 4 -- ds50011Minor allele frequency- T:0.09WA 118
    rs22088401,2
    C,F,O,A,H--11183384(+) ACAGAA/GAAAAC 4 -- ds500117Minor allele frequency- G:0.12NA NS EA WA 928
    rs1167785951,2
    C,F--11183445(+) AATCAT/CAATTT 4 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1867368041,2
    --11183502(+) TGACAC/GAGGAG 4 -- ds50010--------
    rs1924012911,2
    --11183530(+) AGTGGC/TTATGA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for NEDD9 (11183531 - 11382581 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NEDD9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673287CNV Deletion23128226
    esv2514916CNV Deletion19546169
    esv2731591CNV Deletion23290073
    esv7143CNV Gain19470904
    esv6920OTHER Inversion19470904

    Human Gene Mutation Database (HGMD): NEDD9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEDD9
    DNA2.0 Custom Variant and Variant Library Synthesis for NEDD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602265    OMIM disorders: --

    17 diseases for NEDD9:    About MalaCards
    gastrointestinal stromal tumor    pancreatic ductal adenocarcinoma    parkinson's disease    chronic lymphocytic leukemia
    alzheimer's disease    renal cell carcinoma    rheumatoid arthritis    neuroblastoma
    arthritis    hypoxia    adenocarcinoma    hiv-1
    lung cancer    leukemia    pancreatitis    breast cancer
    endotheliitis


    NEDD9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for NEDD9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 21.5 5 12871932 (1), 15214841 (1), 11297557 (1)
    inflammation 0 1 20442290 (1)
    tumors 0 6 12871932 (1), 17703068 (1), 20068165 (1), 11297557 (1)
    cancer 0 1 9584194 (1)
    immunodeficiency 0 1 10835356 (1)

    Genetic Association Database (GAD): NEDD9
    Human Genome Epidemiology (HuGE) Navigator: NEDD9 (9 documents)

    Export disorders for NEDD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEDD9 gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with NEDD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. (PubMed id 9584194)1, 2, 9 Law S.F.... Golemis E.A. (Mol. Cell. Biol. 1998)
    2. T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. (PubMed id 9497377)1, 2, 9 Ohashi Y.... Morimoto C. (J. Biol. Chem. 1998)
    3. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. (PubMed id 8668148)1, 2, 9 Law S.F.... Golemis E.A. (Mol. Cell. Biol. 1996)
    4. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. (PubMed id 8879209)1, 2, 9 Minegishi M.... Morimoto C. (J. Exp. Med. 1996)
    5. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. (PubMed id 9360983)1, 2, 9 Tachibana K.... Morimoto C. (J. Biol. Chem. 1997)
    6. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    7. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. (PubMed id 20413850)1, 4 Laumet G....Lambert J.C. (J. Alzheimers Dis. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (Hum. Mol. Genet. 2010)
    10. Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's disease. (PubMed id 20430066)1, 4 Tedde A....Nacmias B. (Neurosci. Lett. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4739 HGNC: 7733 AceView: NEDD9 Ensembl:ENSG00000111859 euGenes: HUgn4739
    ECgene: NEDD9 H-InvDB: NEDD9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEDD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEDD9 gene:
    Search GeneIP for patents involving NEDD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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