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Aliases for NEDD9 Gene

Aliases for NEDD9 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 2 3
  • Cas Scaffolding Protein Family Member 2 2 3 4
  • HEF1 3 4 6
  • CASL 3 4 6
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 9 3 4
  • Renal Carcinoma Antigen NY-REN-12 3 4
  • CAS-L 3 4
  • CASS2 3 4
  • Crk-Associated Substrate Related Protein Cas-L 3
  • CRK-Associated Substrate-Related Protein 4
  • Enhancer Of Filamentation 1 P55 3
  • Enhancer Of Filamentation 1 3
  • P130Cas-Related Protein 3
  • Cas-Like Docking 3
  • Cas-Like 2
  • NEDD-9 4
  • P105 4
  • CAS2 3

External Ids for NEDD9 Gene

Previous GeneCards Identifiers for NEDD9 Gene

  • GC00U990223
  • GC06M011246
  • GC06M011291

Summaries for NEDD9 Gene

Entrez Gene Summary for NEDD9 Gene

  • The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for NEDD9 Gene

NEDD9 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 9) is a Protein Coding gene. Among its related pathways are Adhesion and B Cell Receptor Signaling Pathway (WikiPathways). An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot for NEDD9 Gene

  • Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form

Gene Wiki entry for NEDD9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD9 Gene

Genomics for NEDD9 Gene

Regulatory Elements for NEDD9 Gene

Genomic Location for NEDD9 Gene

Start:
11,183,298 bp from pter
End:
11,382,348 bp from pter
Size:
199,051 bases
Orientation:
Minus strand

Genomic View for NEDD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEDD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD9 Gene

Proteins for NEDD9 Gene

  • Protein details for NEDD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14511-CASL_HUMAN
    Recommended name:
    Enhancer of filamentation 1
    Protein Accession:
    Q14511
    Secondary Accessions:
    • A8K9G7
    • A8MSJ9
    • G5E9Y9
    • Q5T9R4
    • Q5XKI0

    Protein attributes for NEDD9 Gene

    Size:
    834 amino acids
    Molecular mass:
    92861 Da
    Quaternary structure:
    • Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2, E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK), adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1.

    Three dimensional structures from OCA and Proteopedia for NEDD9 Gene

    Alternative splice isoforms for NEDD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD9 Gene

Proteomics data for NEDD9 Gene at MOPED

Post-translational modifications for NEDD9 Gene

  • Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105 phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected.
  • PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1 cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor. Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD9 Gene

Domains for NEDD9 Gene

Gene Families for NEDD9 Gene

HGNC:
  • CASS :Cas scaffolding proteins

Protein Domains for NEDD9 Gene

Suggested Antigen Peptide Sequences for NEDD9 Gene

Graphical View of Domain Structure for InterPro Entry

Q14511

UniProtKB/Swiss-Prot:

CASL_HUMAN :
  • Q14511
Domain:
  • Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas
  • The SH3 domain interacts with two proline-rich regions of PTK2/FAK1
  • Contains 1 SH3 domain.
Family:
  • Belongs to the CAS family.
genes like me logo Genes that share domains with NEDD9: view

Function for NEDD9 Gene

Molecular function for NEDD9 Gene

UniProtKB/Swiss-Prot Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form
UniProtKB/Swiss-Prot Induction: Activated upon induction of cell growth

Gene Ontology (GO) - Molecular Function for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11827972
genes like me logo Genes that share ontologies with NEDD9: view

Phenotypes for NEDD9 Gene

MGI mutant phenotypes for NEDD9:
inferred from 1 alleles
GenomeRNAi human phenotypes for NEDD9:
genes like me logo Genes that share phenotypes with NEDD9: view

Animal Models for NEDD9 Gene

MGI Knock Outs for NEDD9:

miRNA for NEDD9 Gene

miRTarBase miRNAs that target NEDD9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NEDD9 Gene

Localization for NEDD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD9 Gene

Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle.
Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEDD9 Gene COMPARTMENTS Subcellular localization image for NEDD9 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9584194
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle TAS 9584194
genes like me logo Genes that share ontologies with NEDD9: view

Pathways for NEDD9 Gene

genes like me logo Genes that share pathways with NEDD9: view

Pathways by source for NEDD9 Gene

2 Cell Signaling Technology pathways for NEDD9 Gene
1 BioSystems pathway for NEDD9 Gene

Gene Ontology (GO) - Biological Process for NEDD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 11827972
GO:0007067 mitotic nuclear division IEA --
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 8668148
GO:0007229 integrin-mediated signaling pathway NAS 11827972
genes like me logo Genes that share ontologies with NEDD9: view

Compounds for NEDD9 Gene

(1) HMDB Compounds for NEDD9 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for NEDD9 Gene

Compound -log(P) Hits PubMed IDs
kalinin 71.9 2
tyrosine 51.4 35
threonine 22.8 2
serine 6.69 2
phosphatidylinositol 1.25 2
genes like me logo Genes that share compounds with NEDD9: view

Transcripts for NEDD9 Gene

Unigene Clusters for NEDD9 Gene

Neural precursor cell expressed, developmentally down-regulated 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7: - - - -
SP8:
SP9:

Relevant External Links for NEDD9 Gene

GeneLoc Exon Structure for
NEDD9
ECgene alternative splicing isoforms for
NEDD9

Expression for NEDD9 Gene

mRNA expression in normal human tissues for NEDD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEDD9 Gene

This gene is overexpressed in Lung (4.2) and Adipose - Subcutaneous (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NEDD9 Gene

SOURCE GeneReport for Unigene cluster for NEDD9 Gene Hs.37982

mRNA Expression by UniProt/SwissProt for NEDD9 Gene

Q14511-CASL_HUMAN
Tissue specificity: Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues
genes like me logo Genes that share expressions with NEDD9: view

Orthologs for NEDD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD9 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEDD9 35
  • 81.99 (n)
  • 84.76 (a)
NEDD9 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEDD9 35
  • 87.53 (n)
  • 89.57 (a)
NEDD9 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nedd9 35
  • 84.75 (n)
  • 89.32 (a)
Nedd9 16
Nedd9 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEDD9 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEDD9 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nedd9 35
  • 84.19 (n)
  • 87.52 (a)
chicken
(Gallus gallus)
Aves NEDD9 35
  • 70.18 (n)
  • 68.01 (a)
NEDD9 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEDD9 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd9 35
  • 61.08 (n)
  • 59.15 (a)
zebrafish
(Danio rerio)
Actinopterygii nedd9 35
  • 58.54 (n)
  • 55.66 (a)
nedd9 36
  • 51 (a)
OneToMany
NEDD9 (2 of 2) 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p130CAS 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6681 36
  • 29 (a)
OneToMany
Species with no ortholog for NEDD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD9 Gene

ENSEMBL:
Gene Tree for NEDD9 (if available)
TreeFam:
Gene Tree for NEDD9 (if available)

Paralogs for NEDD9 Gene

Paralogs for NEDD9 Gene

Selected SIMAP similar genes for NEDD9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NEDD9: view

Variants for NEDD9 Gene

Sequence variations from dbSNP and Humsavar for NEDD9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1908 -- 11,184,928(+) CTGTA(C/T)AGTTT utr-variant-3-prime, nc-transcript-variant
rs1911 -- 11,184,951(+) CTTCT(A/G)TGTAT utr-variant-3-prime, nc-transcript-variant
rs2034 -- 11,200,623(+) TAATC(A/C)TTCCT intron-variant, utr-variant-3-prime
rs2950 -- 11,350,032(-) TGAAC(A/G)TCTCA intron-variant
rs3102 -- 11,208,647(+) CCCTG(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD9 Gene

Variant ID Type Subtype PubMed ID
esv7143 CNV Gain 19470904
esv6920 OTHER Inversion 19470904
esv2731591 CNV Deletion 23290073
esv2673287 CNV Deletion 23128226
esv2514916 CNV Deletion 19546169

Relevant External Links for NEDD9 Gene

HapMap Linkage Disequilibrium report
NEDD9
Human Gene Mutation Database (HGMD)
NEDD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD9 Gene

Disorders for NEDD9 Gene

(5) Novoseek inferred disease relationships for NEDD9 Gene

Disease -log(P) Hits PubMed IDs
necrosis 21.5 3
inflammation 0 1
tumors 0 4
cancer 0 1
immunodeficiency 0 1

Relevant External Links for NEDD9

Genetic Association Database (GAD)
NEDD9
Human Genome Epidemiology (HuGE) Navigator
NEDD9
genes like me logo Genes that share disorders with NEDD9: view

No data available for UniProtKB/Swiss-Prot for NEDD9 Gene

Publications for NEDD9 Gene

  1. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. (PMID: 8879209) Minegishi M. … Morimoto C. (J. Exp. Med. 1996) 3 4 23
  2. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. (PMID: 8668148) Law S.F. … Golemis E.A. (Mol. Cell. Biol. 1996) 3 4 23
  3. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. (PMID: 9360983) Tachibana K. … Morimoto C. (J. Biol. Chem. 1997) 3 4 23
  4. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. (PMID: 9584194) Law S.F. … Golemis E.A. (Mol. Cell. Biol. 1998) 3 4 23
  5. T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. (PMID: 9497377) Ohashi Y. … Morimoto C. (J. Biol. Chem. 1998) 3 4 23

Products for NEDD9 Gene

  • Addgene plasmids for NEDD9

Sources for NEDD9 Gene

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