Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEDD9 Gene

protein-coding   GIFtS: 62
GCID: GC06M011183

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 91 2     Cas-Like Docking2
Cas Scaffolding Protein Family Member 21 2 3     Crk-Associated Substrate Related Protein Cas-L2
CASL2 3 5     Enhancer Of Filamentation 12
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 92 3     Enhancer Of Filamentation 1 P552
Renal Carcinoma Antigen NY-REN-122 3     P130Cas-Related Protein2
CAS-L2 3     CasL3
CASS22 3     NEDD-93
HEF12 5     CRK-Associated Substrate-Related Protein3
Cas-like1     hEF13
CAS22     p1053

External Ids:    HGNC: 77331   Entrez Gene: 47392   Ensembl: ENSG000001118597   OMIM: 6022655   UniProtKB: Q145113   

Export aliases for NEDD9 gene to outside databases

Previous GC identifers: GC00U990223 GC06M011246 GC06M011291


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEDD9 Gene:
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are
adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This
protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell
attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported
to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2012)

GeneCards Summary for NEDD9 Gene: 
NEDD9 (neural precursor cell expressed, developmentally down-regulated 9) is a protein-coding gene. Diseases associated with NEDD9 include gastrointestinal stromal tumor, and parkinson's disease. GO annotations related to this gene include protein binding. An important paralog of this gene is BCAR1.

UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery
and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play
an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.
Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the
tyrosine phosphorylated form

Gene Wiki entry for NEDD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEDD9 gene promoter:
         GR   FAC1   GR-beta   GR-alpha   Nkx2-5   STAT5A   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NEDD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEDD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25-p24   Ensembl cytogenetic band:  6p24.2   HGNC cytogenetic band: 6p25-p24

NEDD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M011183:  view genomic region     (about GC identifiers)

Start:
11,183,531 bp from pter      End:
11,382,581 bp from pter
Size:
199,051 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511 (See protein sequence)
Recommended Name: Enhancer of filamentation 1  
Size: 834 amino acids; 92861 Da
Subunit: Interacts with BCAR3 and SH2D3C (By similarity). Homodimer. Can heterodimerize with HLH proteins ID2,
E12, E47 and also with p130cas. Forms complexes in vivo with related adhesion focal tyrosine kinase (RAFTK),
adapter protein CRKL and LYN kinase. Interacts with MICAL and TXNL4/DIM1
Subcellular location: Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm.
Cell junction, focal adhesion. Note=Localizes to both the cell nucleus and the cell periphery and is differently
localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is
present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular
concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly
cytoplasmic and associate with focal adhesions while p55 associates with mitotic spindle
Subcellular location: Enhancer of filamentation 1 p55: Cytoplasm, cytoskeleton, spindle
1 PDB 3D structure from and Proteopedia for NEDD9:
2L81 (3D)    
Secondary accessions: A8K9G7 A8MSJ9 G5E9Y9 Q5T9R4 Q5XKI0
Alternative splicing: 3 isoforms:  Q14511-1   Q14511-2   Q14511-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD9: NX_Q14511

Explore proteomics data for NEDD9 at MOPED 

Post-translational modifications:

  • UniProtKB: Cell cycle-regulated processing produces four isoforms: p115, p105, p65, and p55. Isoform p115 arises from p105
    phosphorylation and appears later in the cell cycle. Isoform p55 arises from p105 as a result of cleavage at a
    caspase cleavage-related site and it appears specifically at mitosis. The p65 isoform is poorly detected
  • UniProtKB: PTK2/FAK1 phosphorylates the protein at the YDYVHL motif (conserved among all cas proteins). The SRC family
    kinases (FYN, SRC, LCK and CRK) are recruited to the phosphorylated sites and can phosphorylate other tyrosine
    residues. Ligation of either integrin beta-1 or B-cell antigen receptor on tonsillar B-cells and B-cell lines
    promotes tyrosine phosphorylation and both integrin and BCR-mediated tyrosine phosphorylation requires an intact
    actin network. In fibroblasts transformation with oncogene v-ABL results in an increase in tyrosine
    phosphorylation. Transiently phosphorylated following CD3 cross-linking and this phosphorylated form binds to CRK
    and C3G. A mutant lacking the SH3 domain is phosphorylated upon CD3 cross-linking but not upon integrin beta-1
    cross-linking. Tyrosine phosphorylation occurs upon stimulation of the G-protein coupled C1a calcitonin receptor.
    Calcitonin-stimulated tyrosine phosphorylation is mediated by calcium- and protein kinase C-dependent mechanisms
    and requires the integrity of the actin cytoskeleton. Phosphorylation at Ser-369 induces proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14511

  • NEDD9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEDD9 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001135865.1  NP_001257962.1  NP_006394.1  NP_892011.2  

    ENSEMBL proteins: 
     ENSP00000368759   ENSP00000395237   ENSP00000422871   ENSP00000368745   ENSP00000421282  
     ENSP00000380534   ENSP00000424975  

    Human Recombinant Protein Products for NEDD9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NEDD9
    OriGene Protein Over-expression Lysate for NEDD9
    OriGene MassSpec for NEDD9 
    OriGene Custom Protein Services for NEDD9
    GenScript Custom Purified and Recombinant Proteins Services for NEDD9
    Novus Biologicals NEDD9 Proteins
    Novus Biologicals NEDD9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEDD9 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS9584194
    GO:0005794Golgi apparatus IEA--
    GO:0005819spindle TAS9584194

    NEDD9 for ontologies           About GeneDecksing



    NEDD9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD9
    R&D Systems Antibodies for NEDD9 (NEDD9/CASL)
    Cell Signaling Technology (CST) Antibodies for NEDD9  (Cas-L)
    OriGene Antibodies for NEDD9
    OriGene Custom Antibody Services for NEDD9
    GenScript Custom Superior Antibodies Services for NEDD9
    Novus Biologicals NEDD9 Antibodies
    Abcam antibodies for NEDD9
    Cloud-Clone Corp. Antibodies for NEDD9 
    ThermoFisher Antibodies for NEDD9
    Search LSBio for Antibodies for NEDD9 

    Assay Products for NEDD9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NEDD9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEDD9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEDD9 
    Cloud-Clone Corp. CLIAs for NEDD9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CASS: Cas scaffolding proteins

    3 InterPro protein domains:
     IPR014928 Serine_rich
     IPR001452 SH3_domain
     IPR021901 CAS_DUF3513

    Graphical View of Domain Structure for InterPro Entry Q14511

    ProtoNet protein and cluster: Q14511

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
    Domain: Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain
    containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2
    domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely
    required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization
    with p130cas
    Domain: The SH3 domain interacts with two proline-rich regions of PTK2/FAK1
    Similarity: Belongs to the CAS family
    Similarity: Contains 1 SH3 domain


    NEDD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CASL_HUMAN, Q14511
    Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to
    cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery
    and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play
    an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells.
    Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the
    tyrosine phosphorylated form
    Induction: Activated upon induction of cell growth

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11827972
         
    NEDD9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NEDD9:
     Stronger migration 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nedd9):
     cellular  hematopoietic system  immune system 

    NEDD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nedd9tm1Miku for NEDD9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEDD9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEDD9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEDD9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEDD9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEDD9
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate NEDD9 (see all 34):
    hsa-miR-2052 hsa-miR-4328 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-766 hsa-miR-4267 hsa-miR-203 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidNEDD9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEDD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEDD9
    Sirion Biotech Customized adenovirus for overexpression of NEDD9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NEDD9 (see all 18)
    OriGene ORF clones in mouse, rat for NEDD9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NEDD9 (NM_182966)
    Sino Biological Human cDNA Clone for NEDD9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD9
    Sirion Biotech Customized lentivirus for stable overexpression of NEDD9 
                         Customized lentivirus expression plasmids for stable overexpression of NEDD9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NEDD9
    Search LifeMap BioReagents cell lines for NEDD9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEDD9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1
    2B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
    3Adhesion
    Adhesion
    4Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NEDD9
        Selected targets of CREB1


    2 Cell Signaling Technology (CST) Pathways for NEDD9
        Adhesion
    Protein Stability

    1 BioSystems Pathway for NEDD9
        B Cell Receptor Signaling Pathway




    NEDD9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEDD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for NEDD9 (Q145112, 3 ENSP000003687594) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J022, 3, ENSP000003639984MINT-50137 MINT-50136 MINT-50139 I2D: score=3 STRING: ENSP00000363998
    SMAD3P840222, 3, ENSP000003329734MINT-8394324 I2D: score=4 STRING: ENSP00000332973
    ENSG00000215641P143733I2D: score=1 
    ENSG00000229006P143733I2D: score=1 
    ENSG00000234495P143733I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS11827972
    GO:0007067mitosis IEA--
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS8668148
    GO:0007229integrin-mediated signaling pathway NAS11827972

    NEDD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEDD9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEDD9 (CASL)

    1 HMDB Compound for NEDD9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for NEDD9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 71.9 2 7615980 (1), 9232815 (1)
    tyrosine 51.4 45 9497377 (6), 19275884 (4), 9886492 (3), 9548475 (3) (see all 14)
    threonine 22.8 3 8522173 (1), 11297557 (1)
    serine 6.69 3 8522173 (1), 11297557 (1)
    phosphatidylinositol 1.25 4 9886492 (1), 9366405 (1)
    glycogen 0.0648 1 12871932 (1)

    Search CenterWatch for drugs/clinical trials and news about NEDD9 / CASL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEDD9 gene (4 alternative transcripts): 
    NM_001142393.1  NM_001271033.1  NM_006403.3  NM_182966.3  

    Unigene Cluster for NEDD9:

    Neural precursor cell expressed, developmentally down-regulated 9
    Hs.37982  [show with all ESTs]
    Unigene Representative Sequence: NR_073131
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379446(uc003mzv.2) ENST00000448183(uc010joz.2 uc003mzw.3)
    ENST00000504387 ENST00000505589 ENST00000379433(uc003mzx.3) ENST00000513989
    ENST00000397378 ENST00000508546 ENST00000468612 ENST00000512665 ENST00000504634
    ENST00000459670 ENST00000514660 ENST00000461055 ENST00000508800
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEDD9
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate NEDD9 (see all 34):
    hsa-miR-2052 hsa-miR-4328 hsa-miR-16-1* hsa-let-7a-2* hsa-miR-766 hsa-miR-4267 hsa-miR-203 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidNEDD9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NEDD9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD9
    Clone
    Products:
         
    OriGene clones in human, mouse for NEDD9 (see all 18)
    OriGene ORF clones in mouse, rat for NEDD9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NEDD9 (NM_182966)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD9
    Sirion Biotech Customized lentivirus for stable overexpression of NEDD9 
                         Customized lentivirus expression plasmids for stable overexpression of NEDD9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NEDD9
    OriGene qSTAR qPCR primer pairs in human, mouse for NEDD9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEDD9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD9

    Additional mRNA sequence: 

    AJ420493.1 AK124210.1 AK292682.1 BC020686.1 BC040207.1 BC050740.1 BX648041.1 L43821.1 
    NR_073131.1 U64317.1 

    24/25 DOTS entries (see all 25):

    DT.116179  DT.99968261  DT.208977  DT.95305057  DT.100791240  DT.100791243  DT.100791235  DT.95305066 
    DT.121391128  DT.100685042  DT.40317109  DT.75151845  DT.40310830  DT.95305061  DT.97763229  DT.100738563 
    DT.121391073  DT.91896798  DT.91979790  DT.92437407  DT.95093967  DT.95305056  DT.100026166  DT.100681502 

    24/279 AceView cDNA sequences (see all 279):

    AA360891 AA370785 BQ652817 BU150121 AA349429 CB215014 BQ643743 N91200 
    AA322558 CR617655 BQ647728 AA369826 BQ721949 BQ646725 AU132178 AA687921 
    BG571963 BM453244 Z42849 AI360799 AA910809 BC020686 AI338165 N27798 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NEDD9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -     -                       -     -     -           -                       -                                       
    SP2:                                                                                      -     -     -           -                                       
    SP3:                          -     -     -                 -     -     -     -           -     -     -                                                   
    SP4:                                                        -     -     -     -           -     -     -           -                                       
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NEDD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEDD9 expression in normal human tissues (normalized intensities)      NEDD9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAAGAGG
    NEDD9 Expression
    About this image


    NEDD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose/nasal cavity   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Trachea
             visceral organ/lung/right lung   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod

    See NEDD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEDD9

    SOURCE GeneReport for Unigene cluster: Hs.37982

    UniProtKB/Swiss-Prot: CASL_HUMAN, Q14511
    Tissue specificity: Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in
    T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and
    in lung tissues

        SABiosciences Custom PCR Arrays for NEDD9
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NEDD9
    OriGene qSTAR qPCR primer pairs in human, mouse for NEDD9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEDD9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEDD9 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd91 , 5 neural precursor cell expressed, developmentally down-regulated more1, 5 84.75(n)1
    89.32(a)1
      13 (20.43 cM)5
    180031  NM_017464.51  NP_059492.31 
     413099165 
    chicken
    (Gallus gallus)
    Aves NEDD91 neural precursor cell expressed, developmentally down-regulated more 69.94(n)
    67.36(a)
      395736  XM_418946.3  XP_418946.3 
    lizard
    (Anolis carolinensis)
    Reptilia NEDD96
    neural precursor cell expressed, developmentally d...
    66(a)
    1 ↔ 1
    GL343209.1(2897060-2974836)
    zebrafish
    (Danio rerio)
    Actinopterygii nedd96
    NEDD9 (2 of 2)6
    neural precursor cell expressed, developmentally d...
    neural precursor cell expressed, developmentally d...
    50(a)
    50(a)
    1 ↔ many
    1 ↔ many
    19(2735728-2791924)
    19(4224836-4278509)
    fruit fly
    (Drosophila melanogaster)
    Insecta p130CAS6
    p130CAS
    21(a)
    1 → many
    3L(152884-174517)


    ENSEMBL Gene Tree for NEDD9 (if available)
    TreeFam Gene Tree for NEDD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEDD9 gene
    BCAR12  CASS42  EFS2  
    2 SIMAP similar genes for NEDD9 using alignment to 5 protein entries:     CASL_HUMAN (see all proteins):
    SH3GL2    BCAR1

    NEDD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4287 SNPs in NEDD9 are shown (see all 4287)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417949111,2
    C--11183057(+) TAAATC/TTCAGT 4 -- ds50010--------
    rs1500610861,2
    --11183137(+) TCATTA/CAATAT 4 -- ds50010--------
    rs1910250711,2
    --11183237(+) ATATTA/GTGAAA 4 -- ds50010--------
    rs1453825201,2
    --11183238(+) TATTAC/TGAAAA 4 -- ds50010--------
    rs1835046841,2
    --11183298(+) GTCTTG/TTTCCA 4 -- ds50010--------
    rs1163906871,2
    C,F--11183344(+) ATTTTC/TTTTGA 4 -- ds50011Minor allele frequency- T:0.09WA 118
    rs22088401,2
    C,F,O,A,H--11183384(+) ACAGAA/GAAAAC 4 -- ds500117Minor allele frequency- G:0.12NA NS EA WA 928
    rs1167785951,2
    C,F--11183445(+) AATCAT/CAATTT 4 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1867368041,2
    --11183502(+) TGACAC/GAGGAG 4 -- ds50010--------
    rs1924012911,2
    --11183530(+) AGTGGC/TTATGA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for NEDD9 (11183531 - 11382581 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NEDD9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673287CNV Deletion23128226
    esv2514916CNV Deletion19546169
    esv2731591CNV Deletion23290073
    esv7143CNV Gain19470904
    esv6920OTHER Inversion19470904


    Human Gene Mutation Database (HGMD): NEDD9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NEDD9
    DNA2.0 Custom Variant and Variant Library Synthesis for NEDD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602265    OMIM disorders: --

    13 diseases for NEDD9:    About MalaCards
    gastrointestinal stromal tumor    parkinson's disease    chronic lymphocytic leukemia    renal cell carcinoma
    glioblastoma    alzheimer's disease    rheumatoid arthritis    colon cancer
    neuroblastoma    arthritis    leukemia    lung cancer
    breast cancer


    NEDD9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for NEDD9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 21.5 5 12871932 (1), 15214841 (1), 11297557 (1)
    inflammation 0 1 20442290 (1)
    tumors 0 6 12871932 (1), 17703068 (1), 20068165 (1), 11297557 (1)
    cancer 0 1 9584194 (1)
    immunodeficiency 0 1 10835356 (1)

    Genetic Association Database (GAD): NEDD9
    Human Genome Epidemiology (HuGE) Navigator: NEDD9 (9 documents)

    Export disorders for NEDD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEDD9 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with NEDD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments. (PubMed id 9584194)1, 2, 9 Law S.F.... Golemis E.A. (1998)
    2. T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G. (PubMed id 9497377)1, 2, 9 Ohashi Y.... Morimoto C. (1998)
    3. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. (PubMed id 8668148)1, 2, 9 Law S.F.... Golemis E.A. (1996)
    4. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. (PubMed id 8879209)1, 2, 9 Minegishi M.... Morimoto C. (1996)
    5. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. (PubMed id 9360983)1, 2, 9 Tachibana K.... Morimoto C. (1997)
    6. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (2011)
    7. Systematic analysis of candidate genes for Alzheimer' s disease in a French, genome-wide association study. (PubMed id 20413850)1, 4 Laumet G....Lambert J.C. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Association of CR1, CLU and PICALM with Alzheimer's d isease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (2010)
    10. Different implication of NEDD9 genetic variant in ear ly and late-onset Alzheimer's disease. (PubMed id 20430066)1, 4 Tedde A....Nacmias B. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4739 HGNC: 7733 AceView: NEDD9 Ensembl:ENSG00000111859 euGenes: HUgn4739
    ECgene: NEDD9 H-InvDB: NEDD9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEDD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEDD9 gene:
    Search GeneIP for patents involving NEDD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD9
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NEDD9 (NEDD9/CASL)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NEDD9   OriGene RNAi products in human, mouse, rat for NEDD9  
     OriGene qPCR primer pairs and template standards for NEDD9   OriGene Protein Over-expression Lysate for NEDD9  
     OriGene MassSpec something-or-other for NEDD9   OriGene clones in human, mouse for NEDD9  
     OriGene qSTAR qPCR primer pairs in human, mouse for NEDD9   OriGene Purified Protein for NEDD9  
     OriGene ORF clones in mouse, rat for NEDD9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEDD9   OriGene Custom Protein Services for NEDD9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEDD9
     QIAGEN SeqTarget long-range PCR primers for resequencing NEDD9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD9
     GenScript Custom Purified and Recombinant Proteins Services for NEDD9 GenScript cDNA clones with any tag delivered in your preferred vector for NEDD9
     GenScript Custom Assay Services for NEDD9 GenScript Custom Superior Antibodies Services for NEDD9
     GenScript Custom overexpressing Cell Line Services for NEDD9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NEDD9  (Cas-L)

     Regulatory tfbs in NEDD9 promoter
     Search Chromatin IP Primers for NEDD9
     RT2 qPCR Primer Assay in human, mouse, rat NEDD9
     GNC Network for NEDD9
     SABiosciences Custom PCR Arrays for NEDD9
     Search Tocris compounds for NEDD9 (CASL)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NEDD9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEDD9 antibodies
     NEDD9 proteins
     NEDD9 lysates
     Antibodies for NEDD9
     See all of Abcam's Antibodies, Kits and Proteins for NEDD9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NEDD9
     Antibodies for NEDD9
     ELISAs for NEDD9
     CLIAs for NEDD9
     Search LifeMap BioReagents cell lines for NEDD9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD9
     SwitchGear 3'UTR luciferase reporter plasmids for NEDD9
     SwitchGear Promoter luciferase reporter plasmids for NEDD9
     ThermoFisher Antibodies for NEDD9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NEDD9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEDD9
    Customized:
     lentivirus for stable overexpression of NEDD9
     lentivirus expression plasmids for stable overexpression of NEDD9
     adenovirus for overexpression of NEDD9
     Search LSBio for Antibodies for NEDD9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NEDD9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4