Aliases for NEDD8-MDP1 Gene
External Ids for NEDD8-MDP1 Gene
- HGNC: 39551
- Entrez Gene: 100528064
- Ensembl: ENSG00000255526
Previous GeneCards Identifiers for NEDD8-MDP1 Gene
- GC14U901228
- GC14M024685
Summaries for NEDD8-MDP1 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for NEDD8-MDP1 Gene
NEDD8-MDP1 (NEDD8-MDP1 Readthrough) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MDP1.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8-MDP1 Gene
Genomics for NEDD8-MDP1 Gene
Regulatory Elements for NEDD8-MDP1 Gene
Enhancers for NEDD8-MDP1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track
Promoters for NEDD8-MDP1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NEDD8-MDP1 Gene
- Chromosome:
- 14
- Start:
- 24,213,937 bp from pter
- End:
- 24,232,370 bp from pter
- Size:
- 18,434 bases
- Orientation:
- Minus strand
Genomic View for NEDD8-MDP1 Gene
Genes around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Ensembl
- 14q by Entrez Gene
- 14q12 by HGNC
NEDD8-MDP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NEDD8-MDP1 Gene
Proteins for NEDD8-MDP1 Gene
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- E9PL57
- Recommended name:
- Protein NEDD8-MDP1
- Protein Accession:
- E9PL57
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19536 Da
- Quaternary structure:
- No Data Available
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- E9PS38
- Recommended name:
- Protein NEDD8-MDP1
- Protein Accession:
- E9PS38
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 67 amino acids
- Molecular mass:
- 7745 Da
- Quaternary structure:
- No Data Available
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- S4R3E9
- Recommended name:
- Protein NEDD8-MDP1
- Protein Accession:
- S4R3E9
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9672 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for NEDD8-MDP1 Gene
No Post-translational modifications
Other Protein References for NEDD8-MDP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for NEDD8-MDP1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEDD8-MDP1
- Search GeneTex for Proteins for NEDD8-MDP1
Assay Products
No data available for DME Specific Peptides for NEDD8-MDP1 Gene
Domains & Families for NEDD8-MDP1 Gene
Protein Domains for NEDD8-MDP1 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene
Function for NEDD8-MDP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
- Search ViGene Biosciences for NEDD8-MDP1
CRISPR Products
- Browse CRISPR knockouts for NEDD8-MDP1
- GenScript: Design CRISPR guide RNA sequences for NEDD8-MDP1
miRNA Products
- Search ViGene Biosciences for NEDD8-MDP1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for NEDD8-MDP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
- Search ViGene Biosciences for NEDD8-MDP1
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8-MDP1 Gene
Localization for NEDD8-MDP1 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEDD8-MDP1 Gene
Pathways & Interactions for NEDD8-MDP1 Gene
More details on SuperPathways for NEDD8-MDP1
No Data Available
Interacting Proteins for NEDD8-MDP1 Gene
No data available for Pathways by source and SIGNOR curated interactions for NEDD8-MDP1 Gene
Transcripts for NEDD8-MDP1 Gene
mRNA/cDNA for NEDD8-MDP1 Gene
- (1) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for NEDD8-MDP1
- GenScript: Design CRISPR guide RNA sequences for NEDD8-MDP1
miRNA Products
- Search ViGene Biosciences for NEDD8-MDP1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
Flow Cytometry Products
Relevant External Links for NEDD8-MDP1 Gene
- GeneLoc Exon Structure for
- NEDD8-MDP1
- ECgene alternative splicing isoforms for
- NEDD8-MDP1
Expression for NEDD8-MDP1 Gene
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NEDD8-MDP1 Gene
Orthologs for NEDD8-MDP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | MDP-1 36 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Mdp1 36 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | NEDD8-MDP1 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | MDP1 36 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 36 |
|
OneToMany |
- Species with no ortholog for NEDD8-MDP1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NEDD8-MDP1 Gene
- ENSEMBL:
- Gene Tree for NEDD8-MDP1 (if available)
- TreeFam:
- Gene Tree for NEDD8-MDP1 (if available)
Paralogs for NEDD8-MDP1 Gene
(10) SIMAP similar genes for NEDD8-MDP1 Gene using alignment to 3 proteins:
Variants for NEDD8-MDP1 Gene
Gene Damage Index Score:
0.04;
0.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NEDD8-MDP1 Gene
- HapMap Linkage Disequilibrium report
- NEDD8-MDP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NEDD8-MDP1 Gene
Disorders for NEDD8-MDP1 Gene
Relevant External Links for NEDD8-MDP1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- NEDD8-MDP1
No disorders were found for NEDD8-MDP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8-MDP1 Gene
Publications for NEDD8-MDP1 Gene
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
Products for NEDD8-MDP1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEDD8-MDP1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- ViGene Biosciences adenoviral particle packaged cDNA for NEDD8-MDP1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
- Search ViGene Biosciences for NEDD8-MDP1
- Search ViGene Biosciences for NEDD8-MDP1
- Search ViGene Biosciences for NEDD8-MDP1
Sources for NEDD8-MDP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon