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Aliases for NEDD8-MDP1 Gene

Aliases for NEDD8-MDP1 Gene

  • NEDD8-MDP1 Readthrough 2 3 5

External Ids for NEDD8-MDP1 Gene

Previous GeneCards Identifiers for NEDD8-MDP1 Gene

  • GC14U901228
  • GC14M024685

Summaries for NEDD8-MDP1 Gene

Entrez Gene Summary for NEDD8-MDP1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEDD8-MDP1 Gene

NEDD8-MDP1 (NEDD8-MDP1 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is MDP1.

Additional gene information for NEDD8-MDP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8-MDP1 Gene

Genomics for NEDD8-MDP1 Gene

GeneHancer (GH) Regulatory Elements for NEDD8-MDP1 Gene

Promoters and enhancers for NEDD8-MDP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024230 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.6 -604 4.2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 GMPR2 NEDD8 NEDD8-MDP1 TM9SF1 RNA5SP383 KHNYN LOC102724814 TINF2 RNF31 MDP1
GH14I024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.7 -40.5 -40456 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC102725044 RABGGTA TSSK4 IPO4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
GH14I024422 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -195.4 -195375 10.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC CBLN3 KHNYN SDR39U1 NYNRIN MDP1 NGDN NFATC4 ENSG00000259321 TINF2 ADCY4
GH14I024194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 +36.5 36493 3.5 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 TM9SF1 PIR45873 RNF31 TINF2 MDP1 SLC22A17 PSME2 KHNYN RNA5SP383 JPH4
GH14I024309 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.9 -81.4 -81360 8.6 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS PAF1 LTB4R CIDEB LTB4R2 KHNYN NGDN NYNRIN RNA5SP383 NFATC4 TM9SF1 SDR39U1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NEDD8-MDP1 Gene

Genomic Locations for NEDD8-MDP1 Gene
chr14:24,213,937-24,232,370
(GRCh38/hg38)
Size:
18,434 bases
Orientation:
Minus strand
chr14:24,683,143-24,701,576
(GRCh37/hg19)

Genomic View for NEDD8-MDP1 Gene

Genes around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8-MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8-MDP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8-MDP1 Gene

Proteins for NEDD8-MDP1 Gene

  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PL57
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PL57

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19536 Da
    Quaternary structure:
    No Data Available
  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PS38
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PS38

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    67 amino acids
    Molecular mass:
    7745 Da
    Quaternary structure:
    No Data Available
  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R3E9
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    S4R3E9

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    84 amino acids
    Molecular mass:
    9672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEDD8-MDP1 Gene

Post-translational modifications for NEDD8-MDP1 Gene

No Post-translational modifications

Other Protein References for NEDD8-MDP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEDD8-MDP1 Gene

Domains & Families for NEDD8-MDP1 Gene

Gene Families for NEDD8-MDP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEDD8-MDP1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Function for NEDD8-MDP1 Gene

Gene Ontology (GO) - Molecular Function for NEDD8-MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with NEDD8-MDP1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8-MDP1 Gene

Localization for NEDD8-MDP1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEDD8-MDP1 Gene

Pathways & Interactions for NEDD8-MDP1 Gene

SuperPathways for NEDD8-MDP1 Gene

No Data Available

Interacting Proteins for NEDD8-MDP1 Gene

Gene Ontology (GO) - Biological Process for NEDD8-MDP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEDD8-MDP1 Gene

Drugs & Compounds for NEDD8-MDP1 Gene

No Compound Related Data Available

Transcripts for NEDD8-MDP1 Gene

mRNA/cDNA for NEDD8-MDP1 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8-MDP1 Gene

No ASD Table

Relevant External Links for NEDD8-MDP1 Gene

GeneLoc Exon Structure for
NEDD8-MDP1
ECgene alternative splicing isoforms for
NEDD8-MDP1

Expression for NEDD8-MDP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD8-MDP1 Gene

mRNA expression in normal human tissues for NEDD8-MDP1 Gene
genes like me logo Genes that share expression patterns with NEDD8-MDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8-MDP1 Gene

Orthologs for NEDD8-MDP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8-MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8-MDP1 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MDP-1 34
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mdp1 34
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii MDP1 34
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
OneToMany
Species where no ortholog for NEDD8-MDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD8-MDP1 Gene

ENSEMBL:
Gene Tree for NEDD8-MDP1 (if available)
TreeFam:
Gene Tree for NEDD8-MDP1 (if available)

Paralogs for NEDD8-MDP1 Gene

Paralogs for NEDD8-MDP1 Gene

(10) SIMAP similar genes for NEDD8-MDP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NEDD8-MDP1: view

Variants for NEDD8-MDP1 Gene

Sequence variations from dbSNP and Humsavar for NEDD8-MDP1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs193921062 uncertain-significance, Malignant tumor of prostate 24,214,313(-) G/C coding_sequence_variant, missense_variant
rs1000014354 -- 24,228,452(-) C/T intron_variant
rs1000034305 -- 24,231,642(-) G/A intron_variant
rs1000035965 -- 24,218,365(-) G/A intron_variant
rs1000169072 -- 24,213,821(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD8-MDP1 Gene

Variant ID Type Subtype PubMed ID
esv3633803 CNV loss 21293372

Variation tolerance for NEDD8-MDP1 Gene

Gene Damage Index Score: 0.04; 0.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NEDD8-MDP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD8-MDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Disorders for NEDD8-MDP1 Gene

Additional Disease Information for NEDD8-MDP1

No disorders were found for NEDD8-MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8-MDP1 Gene

Publications for NEDD8-MDP1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for NEDD8-MDP1 Gene

Sources for NEDD8-MDP1 Gene

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