Aliases for NEDD8-MDP1 Gene
External Ids for NEDD8-MDP1 Gene
- HGNC: 39551
- Entrez Gene: 100528064
- Ensembl: ENSG00000255526
Previous GeneCards Identifiers for NEDD8-MDP1 Gene
- GC14U901228
- GC14M024685
Summaries for NEDD8-MDP1 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]
GeneCards Summary for NEDD8-MDP1 Gene
NEDD8-MDP1 (NEDD8-MDP1 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity. An important paralog of this gene is MDP1.
Additional gene information for NEDD8-MDP1 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8-MDP1 Gene
Genomics for NEDD8-MDP1 Gene
GeneHancer (GH) Regulatory Elements for NEDD8-MDP1 Gene
Promoters and enhancers for NEDD8-MDP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NEDD8-MDP1 Gene
Genomic Locations for NEDD8-MDP1 Gene
- chr14:24,213,937-24,232,370
- (GRCh38/hg38)
- Size:
- 18,434 bases
- Orientation:
- Minus strand
- chr14:24,683,143-24,701,576
- (GRCh37/hg19)
Genomic View for NEDD8-MDP1 Gene
Genes around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Ensembl
- 14q12 by Entrez Gene
- 14q12 by HGNC
NEDD8-MDP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NEDD8-MDP1 Gene
Proteins for NEDD8-MDP1 Gene
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- E9PL57
- Recommended name:
- NEDD8-MDP1 readthrough
- Protein Accession:
- E9PL57
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 170 amino acids
- Molecular mass:
- 19536 Da
- Quaternary structure:
- No Data Available
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- E9PS38
- Recommended name:
- NEDD8-MDP1 readthrough
- Protein Accession:
- E9PS38
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 67 amino acids
- Molecular mass:
- 7745 Da
- Quaternary structure:
- No Data Available
-
Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- S4R3E9
- Recommended name:
- NEDD8-MDP1 readthrough
- Protein Accession:
- S4R3E9
Protein attributes for NEDD8-MDP1 Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9672 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for NEDD8-MDP1 Gene
No Post-translational modifications
Other Protein References for NEDD8-MDP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NEDD8-MDP1
- Origene Custom Protein Services for NEDD8-MDP1
- Search GeneTex for Proteins for NEDD8-MDP1
Assay Products
No data available for DME Specific Peptides for NEDD8-MDP1 Gene
Domains & Families for NEDD8-MDP1 Gene
Gene Families for NEDD8-MDP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NEDD8-MDP1 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene
Function for NEDD8-MDP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016791 | phosphatase activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NEDD8-MDP1
-
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
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CRISPR Products
- Browse CRISPR knockouts for NEDD8-MDP1
- genomics-online: gRNA clones - Search results for available NEDD8-MDP1 gene related products
- Applied Biological Materials CRISPR for NEDD8-MDP1
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for NEDD8-MDP1
miRNA Products
- Search ViGene Biosciences for NEDD8-MDP1
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available NEDD8-MDP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for NEDD8-MDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NEDD8-MDP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NEDD8-MDP1 gene related products
- orf clones - Search results for available NEDD8-MDP1 gene related products
- Applied Biological Materials Clones for NEDD8-MDP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NEDD8-MDP1
-
ViGene Biosciences adenoviral particle packaged cDNA for NEDD8-MDP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
- Search ViGene Biosciences for NEDD8-MDP1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8-MDP1 Gene
Localization for NEDD8-MDP1 Gene
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEDD8-MDP1 Gene
Pathways & Interactions for NEDD8-MDP1 Gene
No Data Available
Interacting Proteins for NEDD8-MDP1 Gene
No data available for Pathways by source and SIGNOR curated interactions for NEDD8-MDP1 Gene
Transcripts for NEDD8-MDP1 Gene
mRNA/cDNA for NEDD8-MDP1 Gene
- (1) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for NEDD8-MDP1
- genomics-online: gRNA clones - Search results for available NEDD8-MDP1 gene related products
- Applied Biological Materials CRISPR for NEDD8-MDP1
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for NEDD8-MDP1
miRNA Products
- Search ViGene Biosciences for NEDD8-MDP1
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available NEDD8-MDP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NEDD8-MDP1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for NEDD8-MDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NEDD8-MDP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available NEDD8-MDP1 gene related products
- orf clones - Search results for available NEDD8-MDP1 gene related products
- Applied Biological Materials Clones for NEDD8-MDP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for NEDD8-MDP1 Gene
- GeneLoc Exon Structure for
- NEDD8-MDP1
- ECgene alternative splicing isoforms for
- NEDD8-MDP1
Expression for NEDD8-MDP1 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD8-MDP1 Gene
Primer Products
- genomics-online: primer clones - Search results for available NEDD8-MDP1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8-MDP1 Gene
Orthologs for NEDD8-MDP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NEDD8-MDP1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MDP-1 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Mdp1 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | MDP1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 34 |
|
OneToMany |
- Species where no ortholog for NEDD8-MDP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NEDD8-MDP1 Gene
- ENSEMBL:
- Gene Tree for NEDD8-MDP1 (if available)
- TreeFam:
- Gene Tree for NEDD8-MDP1 (if available)
Paralogs for NEDD8-MDP1 Gene
Variants for NEDD8-MDP1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921062 | uncertain-significance, Malignant tumor of prostate | 24,214,313(-) | G/C | coding_sequence_variant, missense_variant | |
| rs1000014354 | -- | 24,228,452(-) | C/T | intron_variant | |
| rs1000034305 | -- | 24,231,642(-) | G/A | intron_variant | |
| rs1000035965 | -- | 24,218,365(-) | G/A | intron_variant | |
| rs1000169072 | -- | 24,213,821(-) | G/A | downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3633803 | CNV | loss | 21293372 |
Gene Damage Index Score:
0.04;
0.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NEDD8-MDP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NEDD8-MDP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene
Disorders for NEDD8-MDP1 Gene
Additional Disease Information for NEDD8-MDP1
No disorders were found for NEDD8-MDP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8-MDP1 Gene
Publications for NEDD8-MDP1 Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
Products for NEDD8-MDP1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for NEDD8-MDP1
- VectorBuilder custom plasmid, inducible vectors for NEDD8-MDP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NEDD8-MDP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available NEDD8-MDP1 related products ranked by validation data
- antibodies-online: Search results for available NEDD8-MDP1 related products ranked by validation data
- antibodies-online: Search results for available NEDD8-MDP1 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for NEDD8-MDP1 gene
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- Horizon Cell Lines for NEDD8-MDP1
- genomics-online: cdna clones - Search results for available NEDD8-MDP1 gene related products
- orf clones - Search results for available NEDD8-MDP1 gene related products
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Sources for NEDD8-MDP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew