NEDD8-MDP1 Gene
protein-coding GIFtS: 17
GCID: GC14M024685
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NEDD8-MDP1 Readthrough
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Aliases
for NEDD8-MDP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| NEDD8-MDP1 Readthrough1 2 | | NEDD8-MDP1 Protein2 | | NEDD8-MDP1 Read-Through Transcript2 |
Export aliases for NEDD8-MDP1 gene to outside databasesPrevious GC identifer: GC14U901228 |
Summaries
for NEDD8-MDP1 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for NEDD8-MDP1 Gene:
This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural
precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on
chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with the
products of each individual gene. (provided by RefSeq, Dec 2010)
GeneCards Summary for NEDD8-MDP1 Gene:
NEDD8-MDP1 (NEDD8-MDP1 readthrough) is a protein-coding gene. An important paralog of this gene is MDP1.
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Genomic Views
for NEDD8-MDP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for NEDD8-MDP1
Other transcription factors
Search Chromatin IP Primers for NEDD8-MDP1
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD8-MDP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12NEDD8-MDP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024685: view genomic region
(about GC identifiers)
Start:
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24,683,143 bp from pter |
End:
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24,701,576 bp from pter |
Size:
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18,434 bases |
Orientation:
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minus strand |
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Proteins
for NEDD8-MDP1 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/TrEMBL: E9PL57 (See
protein sequence)Recommended Name: Protein NEDD8-MDP1 Size: 170 amino acids; 19536 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary dataUniProtKB/TrEMBL: E9PS38 (See
protein sequence) Recommended Name: Protein NEDD8-MDP1 Size: 67 amino acids; 7745 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary dataUniProtKB/TrEMBL: S4R3E9 (See
protein sequence) Recommended Name: Protein NEDD8-MDP1 Size: 84 amino acids; 9672 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary dataREFSEQ proteins: NP_001186752.1
ENSEMBL proteins: ENSP00000474249 ENSP00000431482 ENSP00000432117
NEDD8-MDP1 Human Recombinant
Protein Products:NEDD8-MDP1 Antibody
Products:NEDD8-MDP1 Assay Products: |
Domains /
Families
for NEDD8-MDP1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | Selected InterPro protein domains (see all 6):Graphical View of Domain Structure for InterPro Entry E9PL57Graphical View of Domain Structure for InterPro Entry E9PS38Graphical View of Domain Structure for InterPro Entry S4R3E9 ProtoNet protein and cluster: E9PL57
NEDD8-MDP1 for domains About GeneDecksing
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Function
for NEDD8-MDP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 2 molecular function terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0016791 | phosphatase activity |
-- | -- |
NEDD8-MDP1 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | Browse OriGene RNAi
| | | Predesigned siRNA for gene silencing in human, mouse, rat NEDD8-MDP1 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for NEDD8-MDP1 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for NEDD8-MDP1  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD8-MDP1 |
Localization
for NEDD8-MDP1 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
-- | -- |
NEDD8-MDP1 for ontologies About GeneDecksing
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Pathways & Interactions
for NEDD8-MDP1 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEDD8-MDP1
Interactions:
Search GeneGlobe Interaction Network for NEDD8-MDP1
Gene Ontology (GO): 4 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0008104 | protein localization |
-- | -- | | GO:0014070 | response to organic cyclic compound |
-- | -- | | GO:0045116 | protein neddylation |
-- | -- |
NEDD8-MDP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEDD8-MDP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for NEDD8-MDP1
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Transcripts
for NEDD8-MDP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for NEDD8-MDP1 gene: NM_001199823.1 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000605847 ENST00000534348 ENST00000530579 ENST00000604306
Inhib. RNA
Products: | | Browse OriGene RNAi
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat NEDD8-MDP1 |
GeneLoc Exon Structure
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Expression
for NEDD8-MDP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NEDD8-MDP1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image NEDD8-MDP1 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for NEDD8-MDP1
Primer
Products: | | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat NEDD8-MDP1 | | | QuantiTect SYBR Green Assays in human, mouse, rat NEDD8-MDP1 | | | QuantiFast Probe-based Assays in human, mouse, rat NEDD8-MDP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD8-MDP1 |
Orthologs
for NEDD8-MDP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of animals and fungi.
Orthologs for NEDD8-MDP1 gene from Selected species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
Uncharacterized protein |
64(a) |
1 → many |
GL343400.1(95841-99087) |
zebrafish
(Danio rerio) |
Actinopterygii |
MDP16 |
magnesium-dependent phosphatase 1 |
38(a) |
1 → many |
23(41030006-41040760) ENSDARG00000088040 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
-- |
Magnesium-dependent acid phosphatase, member of th... |
21(a) |
1 → many |
V(437267-437803) YER134C |
Species with no ortholog for NEDD8-MDP1
ENSEMBL Gene Tree for NEDD8-MDP1 (if available)
TreeFam Gene Tree for NEDD8-MDP1 (if available) |
Paralogs
for NEDD8-MDP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for NEDD8-MDP1 gene
- MDP12
10 SIMAP similar genes for NEDD8-MDP1 using alignment to 3 protein entries: E9PL57_HUMAN (see all proteins):MDP-1 NEDD8 MDP1 UbC UBA52 UBBP4
RPS27A UBB UBC RAD23A
NEDD8-MDP1 for paralogs About GeneDecksing
|
Genomic Variants
for NEDD8-MDP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
TryGeneCards Plus | | | Site Specific Mutation Identification with PCR Assays |
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Disorders
/ Diseases
for NEDD8-MDP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for NEDD8-MDP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for NEDD8-MDP1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NEDD8-MDP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
- Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
- Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
- Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
- A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
- Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
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External Searches for NEDD8-MDP1 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NEDD8-MDP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NEDD8-MDP1 gene
(According to HUGE)
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Specialized Databases showing NEDD8-MDP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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TryGeneCards Plus | Patent Information for NEDD8-MDP1 gene:
Search GeneIP for patents involving NEDD8-MDP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NEDD8-MDP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat NEDD8-MDP1 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing NEDD8-MDP1 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD8-MDP1 | | Predesigned siRNA for gene silencing in human, mouse, rat NEDD8-MDP1 | | | QuantiFast Probe-based Assays in human, mouse, rat NEDD8-MDP1 | | QuantiTect SYBR Green Assays in human, mouse, rat NEDD8-MDP1 | | | Custom PCR Arrays for NEDD8-MDP1 | | Search Chromatin IP Primers for NEDD8-MDP1 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NEDD8-MDP1 | | Search GeneGlobe Interaction Network for NEDD8-MDP1 | | | Search Regulatory tfbs for NEDD8-MDP1 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD8-MDP1 |
| |  |  |  |  | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEDD8-MDP1 |
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