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NEDD8-MDP1 Gene(Protein Coding)

NEDD8-MDP1 Readthrough

GCID:
GC14M024213
GIFtS:
25
Genes Participants
UDN Logo

Aliases for NEDD8-MDP1 Gene

Aliases for NEDD8-MDP1 Gene

  • NEDD8-MDP1 Readthrough 2 3 5

External Ids for NEDD8-MDP1 Gene

Previous GeneCards Identifiers for NEDD8-MDP1 Gene

  • GC14U901228
  • GC14M024685

Summaries for NEDD8-MDP1 Gene

Entrez Gene Summary for NEDD8-MDP1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on chromosome 14. One of the read-through transcripts on this locus encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for NEDD8-MDP1 Gene

NEDD8-MDP1 (NEDD8-MDP1 Readthrough) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is MDP1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8-MDP1 Gene

Genomics for NEDD8-MDP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NEDD8-MDP1 Gene

Enhancers for NEDD8-MDP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -195.4 -195376 10.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CBLN3 KHNYN MDP1 NYNRIN ENSG00000259321 TINF2 ADCY4 NEDD8 NEDD8-MDP1 SDR39U1
GH14G024270 1.5 FANTOM5 ENCODE 11.7 -40.5 -40456 5.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DHRS1 TINF2 LTB4R KHNYN NEDD8-MDP1 NEDD8 NOP9 GMPR2 MDP1 CHMP4A
GH14G024277 1.4 FANTOM5 Ensembl ENCODE 12.2 -47.2 -47231 5.2 CTCF PKNOX1 USF1 NFIB MAX EBF1 RAD21 RELA RFX5 NFYB DHRS1 TINF2 NOP9 LTB4R2 LTB4R CIDEB NEDD8-MDP1 NEDD8 GMPR2 MDP1
GH14G024309 1.3 ENCODE dbSUPER 10.9 -81.4 -81360 8.6 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B DMAP1 YY1 SLC30A9 ZNF207 LTB4R DHRS1 PABPN1 NEDD8-MDP1 NEDD8 CBLN3 KHNYN NYNRIN TGM1 GC14M024319
GH14G024194 1.1 ENCODE 11.5 +36.5 36494 3.5 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 MDP1 REC8 NEDD8-MDP1 NEDD8 TINF2 RNF31 PSME2 PABPN1 TGM1 NFATC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Promoters for NEDD8-MDP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066843 -30 2001 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for NEDD8-MDP1 Gene

Chromosome:
14
Start:
24,213,937 bp from pter
End:
24,232,370 bp from pter
Size:
18,434 bases
Orientation:
Minus strand

Genomic View for NEDD8-MDP1 Gene

Genes around NEDD8-MDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8-MDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8-MDP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NEDD8-MDP1 Gene

Proteins for NEDD8-MDP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PL57
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PL57

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19536 Da
    Quaternary structure:
    No Data Available

  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PS38
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    E9PS38

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    67 amino acids
    Molecular mass:
    7745 Da
    Quaternary structure:
    No Data Available

  • Protein details for NEDD8-MDP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R3E9
    Recommended name:
    NEDD8-MDP1 readthrough
    Protein Accession:
    S4R3E9

    Protein attributes for NEDD8-MDP1 Gene

    Size:
    84 amino acids
    Molecular mass:
    9672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NEDD8-MDP1 Gene

Post-translational modifications for NEDD8-MDP1 Gene

No Post-translational modifications

Other Protein References for NEDD8-MDP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NEDD8-MDP1 Gene

Domains & Families for NEDD8-MDP1 Gene

Protein Domains for NEDD8-MDP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NEDD8-MDP1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Function for NEDD8-MDP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for NEDD8-MDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with NEDD8-MDP1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8-MDP1 Gene

Localization for NEDD8-MDP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NEDD8-MDP1 Gene

Pathways & Interactions for NEDD8-MDP1 Gene

SuperPathways for NEDD8-MDP1 Gene

PathCards logo More details on SuperPathways for NEDD8-MDP1
No Data Available

Interacting Proteins for NEDD8-MDP1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000431482%0d%0a9606.ENSP00000326804%0d%0a9606.ENSP00000358147%0d%0a9606.ENSP00000264414%0d%0a9606.ENSP00000384109%0d%0a9606.ENSP00000364589%0d%0a
Selected Interacting proteins: ENSP00000431482 for NEDD8-MDP1 Gene via STRING

Gene Ontology (GO) - Biological Process for NEDD8-MDP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NEDD8-MDP1 Gene

Drugs & Compounds for NEDD8-MDP1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NEDD8-MDP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NEDD8-MDP1 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8-MDP1 Gene

No ASD Table

Relevant External Links for NEDD8-MDP1 Gene

GeneLoc Exon Structure for
NEDD8-MDP1
ECgene alternative splicing isoforms for
NEDD8-MDP1

Expression for NEDD8-MDP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD8-MDP1 Gene

mRNA expression in normal human tissues for NEDD8-MDP1 Gene
genes like me logo Genes that share expression patterns with NEDD8-MDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8-MDP1 Gene

Orthologs for NEDD8-MDP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8-MDP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NEDD8-MDP1 35
  • 94 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MDP-1 35
  • 64 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Mdp1 35
  • 61 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 56 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 55 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 64 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii MDP1 35
  • 38 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 35
  • 21 (a)
 OneToMany
Species where no ortholog for NEDD8-MDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD8-MDP1 Gene

ENSEMBL:
Gene Tree for NEDD8-MDP1 (if available)
TreeFam:
Gene Tree for NEDD8-MDP1 (if available)

Paralogs for NEDD8-MDP1 Gene

Paralogs for NEDD8-MDP1 Gene

(10) SIMAP similar genes for NEDD8-MDP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NEDD8-MDP1: view

Variants for NEDD8-MDP1 Gene

Sequence variations from dbSNP and Humsavar for NEDD8-MDP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193921062 Uncertain significance 24,214,313(-) GCAAA(C/G)TGGGT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000014354 -- 24,228,452(+) GCTCA(C/T)GGCTG intron-variant
rs1000034305 -- 24,231,642(+) GCAGC(A/G)GTAAC intron-variant, upstream-variant-2KB
rs1000035965 -- 24,218,365(+) GAAGA(A/G)GAGTT intron-variant
rs1000169072 -- 24,213,821(+) TTGGG(A/G)TTGCC intron-variant, downstream-variant-500B, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NEDD8-MDP1 Gene

Variant ID Type Subtype PubMed ID
esv3633803 CNV loss 21293372

Variation tolerance for NEDD8-MDP1 Gene

Gene Damage Index Score: 0.04; 0.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEDD8-MDP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD8-MDP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD8-MDP1 Gene

Disorders for NEDD8-MDP1 Gene

Relevant External Links for NEDD8-MDP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEDD8-MDP1

No disorders were found for NEDD8-MDP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8-MDP1 Gene

Publications for NEDD8-MDP1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for NEDD8-MDP1 Gene

Sources for NEDD8-MDP1 Gene

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