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NEDD8-MDP1 Gene

protein-coding   GIFtS: 17
GCID: GC14M024685

NEDD8-MDP1 Readthrough

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Aliases
for NEDD8-MDP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NEDD8-MDP1 Readthrough1 2
NEDD8-MDP1 Protein2
NEDD8-MDP1 Read-Through Transcript2

External Ids:    HGNC: 395511   Entrez Gene: 1005280642   Ensembl: ENSG000002555267   UniProtKB: E9PL574   UniProtKB: E9PS384   
UniProtKB: S4R3E94   

Export aliases for NEDD8-MDP1 gene to outside databases

Previous GC identifer: GC14U901228


Summaries
for NEDD8-MDP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NEDD8-MDP1 Gene:
This locus represents naturally occurring read-through transcription between the neighboring NEDD8 (neural
precursor cell expressed, developmentally down-regulated 8) and MDP1 (magnesium-dependent phosphatase 1) genes on
chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with the
products of each individual gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for NEDD8-MDP1 Gene:
NEDD8-MDP1 (NEDD8-MDP1 readthrough) is a protein-coding gene. An important paralog of this gene is MDP1.




Genomic Views
for NEDD8-MDP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for NEDD8-MDP1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD8-MDP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

NEDD8-MDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD8-MDP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024685:  view genomic region     (about GC identifiers)

Start:
 24,683,143 bp from pter      End:
 24,701,576 bp from pter
Size:
 18,434 bases      Orientation:
 minus strand

Proteins
for NEDD8-MDP1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: E9PL57 (See protein sequence)
Recommended Name: Protein NEDD8-MDP1  
Size: 170 amino acids; 19536 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: E9PS38 (See protein sequence)

Recommended Name: Protein NEDD8-MDP1  
Size: 67 amino acids; 7745 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: S4R3E9 (See protein sequence)

Recommended Name: Protein NEDD8-MDP1  
Size: 84 amino acids; 9672 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins: NP_001186752.1  
ENSEMBL proteins: 
 ENSP00000474249   ENSP00000431482   ENSP00000432117  

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Domains /
Families
for NEDD8-MDP1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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TryGeneCards Plus		 Selected InterPro protein domains (see all 6):
 IPR023214 HAD-like_dom
 IPR019954 Ubiquitin_CS
 IPR010036 MDP_1_eu_arc
 IPR000626 Ubiquitin_dom
 IPR019956 Ubiquitin

Graphical View of Domain Structure for InterPro Entry E9PL57
Graphical View of Domain Structure for InterPro Entry E9PS38
Graphical View of Domain Structure for InterPro Entry S4R3E9

ProtoNet protein and cluster: E9PL57


Find genes that share domains with NEDD8-MDP1           About GenesLikeMe


Function
for NEDD8-MDP1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0016791phosphatase activity ----
     
Find genes that share ontologies with NEDD8-MDP1           About GenesLikeMe


Animal Models:
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Localization
for NEDD8-MDP1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----

Find genes that share ontologies with NEDD8-MDP1           About GenesLikeMe


Pathways & Interactions
for NEDD8-MDP1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006357regulation of transcription from RNA polymerase II promoter ----
GO:0008104protein localization ----
GO:0014070response to organic cyclic compound ----
GO:0045116protein neddylation ----

Find genes that share ontologies with NEDD8-MDP1           About GenesLikeMe



Drugs & Compounds
for NEDD8-MDP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for NEDD8-MDP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NEDD8-MDP1 gene: 
NM_001199823.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000605847 ENST00000534348 ENST00000530579 ENST00000604306
miRNA
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GeneLoc Exon Structure


Expression
for NEDD8-MDP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NEDD8-MDP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NEDD8-MDP1 Expression
About this image

NEDD8-MDP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:  --
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Orthologs
for NEDD8-MDP1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8-MDP1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 Uncharacterized protein
 64(a)
 1 → many
 GL343400.1(95841-99087)
zebrafish
(Danio rerio)		 Actinopterygii MDP16
 magnesium-dependent phosphatase 1
 38(a)
 1 → many
 23(41030006-41040760) ENSDARG00000088040
baker's yeast
(Saccharomyces cerevisiae)		 Saccharomycetes --
 Magnesium-dependent acid phosphatase, member of th...
 21(a)
 1 → many
 V(437267-437803) YER134C
        Species with no ortholog for NEDD8-MDP1

ENSEMBL Gene Tree for NEDD8-MDP1 (if available)
TreeFam Gene Tree for NEDD8-MDP1 (if available)

Paralogs
for NEDD8-MDP1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NEDD8-MDP1 gene
MDP12  
10 SIMAP similar genes for NEDD8-MDP1 using alignment to 3 protein entries:     E9PL57_HUMAN (see all proteins):
MDP-1    NEDD8    MDP1    UbC    UBA52    UBBP4
RPS27A    UBB    UBC    RAD23A

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Genomic Variants
for NEDD8-MDP1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
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Disorders / Diseases
for NEDD8-MDP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for NEDD8-MDP1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NEDD8-MDP1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NEDD8-MDP1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  7. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

External Searches for NEDD8-MDP1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing NEDD8-MDP1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100528064 HGNC: 39551 Ensembl:ENSG00000255526 euGenes: HUgn100528064 ECgene: NEDD8-MDP1
H-InvDB: NEDD8-MDP1

Other Databases showing NEDD8-MDP1 gene

(According to HUGE)
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Specialized Databases showing NEDD8-MDP1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Intellectual Property
for NEDD8-MDP1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for NEDD8-MDP1 gene:
Search GeneIP for patents involving NEDD8-MDP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for NEDD8-MDP1
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 Search ThermoFisher Antibodies for NEDD8-MDP1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NEDD8-MDP1
 Browse compounds at ApexBio
 Search Addgene for plasmids for NEDD8-MDP1
  Search eBioscience for proteins for NEDD8-MDP1
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for NEDD8-MDP1
  Search antibodies-online for antibodies for NEDD8-MDP1
  Search antibodies-online for kits for NEDD8-MDP1
  Search antibodies-online for peptides for NEDD8-MDP1
  Search antibodies-online for proteins for NEDD8-MDP1
       
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