NEDD8 Gene
protein-coding GIFtS: 62
GCID: GC14M024686
|
|
neural precursor cell expressed, developmentally down-regulated...
| |
Aliases
for NEDD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neural Precursor Cell Expressed, Developmentally Down-Regulated 81 2 | | Neddylin3 | | Ubiquitin-Like Protein Nedd82 3 | | Neddylin3 | | NEDD-82 3 | | Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 83 | | Nedd-81 | | |
Export aliases for NEDD8 gene to outside databasesPrevious GC identifers: GC14M022058 GC14M018473 GC14M022674 GC14M022676 GC14M023755 GC14M004801 |
Summaries
for NEDD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalentattachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzymeUBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotespolyubiquitination and proteasomal degradation of cyclins and other regulatory proteins
Gene Wiki entry for NEDD8
|
Genomic Views
for NEDD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEDD8 gene promoter:
POU2F1 POU2F1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEDD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2NEDD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024686: view genomic region
(about GC identifiers)
Start:
|
24,686,057 bp from pter |
End:
|
24,701,660 bp from pter |
Size:
|
15,604 bases |
Orientation:
|
minus strand |
|
Proteins
for NEDD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843 (See
protein sequence)Recommended Name: NEDD8 precursor Size: 81 amino acids; 9072 Da
Subunit: Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53
Subcellular location: Nucleus. Note=Mainly nuclear
6/15 PDB 3D structures from  and Proteopedia  for NEDD8 (see all 15):1NDD (3D)
1R4M (3D)
1R4N (3D)
1XT9 (3D)
2BKR (3D)
2KO3 (3D)
Secondary accessions: Q3SXN8 Q6LES6Explore the universe of human proteins at neXtProt for NEDD8: NX_Q15843
Post-translational modifications:
Cleavage of precursor form by UCHL3 or SENP8 is necessary for function1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15843
NEDD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006147.1
ENSEMBL proteins: ENSP00000250495 ENSP00000380040 ENSP00000448192
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
NEDD8 for ontologies About GeneDecksing
NEDD8 Antibody Products:
Assay Products for NEDD8: |
Protein
Domains /
Families
for NEDD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEDD8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15843ProtoNet protein and cluster: Q15843 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843Similarity: Belongs to the ubiquitin family |
Function
for NEDD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalentattachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzymeUBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotespolyubiquitination and proteasomal degradation of cyclins and other regulatory proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NEDD8 (NM_006156) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEDD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NEDD8 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NEDD8:
|
Pathways & Interactions
for NEDD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Role of SCF complex in cell cycle regulation | | | 2 | Protein Stability | | | 3 | AHR Pathway | | | 4 | p53 pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NEDD8
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NEDD8
1 
Cell Signaling Technology (CST) Pathway for NEDD8
1  GeneGo (Thomson Reuters) Pathway for NEDD8
1  BioSystems Pathway for NEDD8
NEDD8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEDD8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/231 Interacting proteins for NEDD8 (Q158432, 3 ENSP000002504954) via UniProtKB, MINT, STRING, and/or I2D (see all 231)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CUL1 | Q136162, 3, ENSP000003268044 | MINT-6542674 MINT-4544716 MINT-8092276 MINT-7294697 I2D:
score=5 STRING: ENSP00000326804 | | CUL2 | Q136172, 3, ENSP000003638804 | MINT-8295466 MINT-8295524 MINT-6542674 MINT-8295501 I2D:
score=3 STRING: ENSP00000363880 | | RPL11 | P629132, 3, ENSP000003636764 | MINT-7294622 MINT-6542674 MINT-6541111 MINT-7294570 I2D:
score=2 STRING: ENSP00000363676 | | RPL9 | P329692, 3, ENSP000003460224 | MINT-6542674 I2D:
score=1 STRING: ENSP00000346022 | | NUB1 | Q9Y5A72, 3, ENSP000003986444 | MINT-50774 MINT-50772 MINT-50773 I2D:
score=1 STRING: ENSP00000398644 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
NEDD8 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEDD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NEDD8 for compounds About GeneDecksing
 Browse Tocris compounds for NEDD8
5 Novoseek chemical compound relationships for NEDD8 gene About this table
Search CenterWatch for drugs/clinical trials and news about NEDD8
|
Transcripts
for NEDD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NEDD8 gene: NM_006156.2 Unigene Cluster for NEDD8: Neural precursor cell expressed, developmentally down-regulated 8 Hs.531064 [show with all ESTs]Unigene Representative Sequence: AK1252148 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000250495(uc001wnn.2) ENST00000396828(uc001wno.2) ENST00000527046
ENST00000531430 ENST00000560427 ENST00000526430 ENST00000524927 ENST00000533242(uc001wnp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NEDD8 (NM_006156) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NEDD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD8 |
Additional cDNA sequence: AK125214.1 BC104200.1 BC104201.1 BC104664.1 CR407662.1 D23662.1 13 DOTS entries: DT.95225587 DT.40284385 DT.455838 DT.99950778 DT.40115876 DT.87000939 DT.100845971 DT.40290821 DT.100042140 DT.91666339 DT.91861974 DT.100042141 DT.91915964 24/554 AceView cDNA sequences (see all 554): CB321698 BM507263 BQ949724 BC064899 BQ056166 BQ221197 BM478158 BP429915 AA725123 BQ632245 BQ774333 BM842036 BE395591 BC051382 AI700544 AI354437 AI085668 BF126026 CB109528 CF130271 BM840957 BM565531 BM710198 BQ941018
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NEDD8
|
Expression
for NEDD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NEDD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTACAAA
About this image
See NEDD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEDD8
SOURCE GeneReport for Unigene cluster: Hs.531064
UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon andleukocytes
SABiosciences Expression via Pathway-Focused PCR Array including NEDD8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEDD8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEDD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD8 |
Orthologs
for NEDD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NEDD8 gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008587761 |
NEDD8-like |
88(n)
100(a) |
|
100858776 XM_003643561.1 XP_003643609.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.29522 |
Xenopus laevis transcribed sequence with strong similarity more |
77.98(n) |
|
48024167 |
zebrafish
(Danio rerio) |
Actinopterygii |
nedd82 |
neural precursor cell expressed, developmentally down-regulated more |
81.39(n) |
|
368667 BC055645.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nedd81 , 3 |
protein degradation tagging3
CG10679-PA1 |
89(a)3
75.53(n)1
89.87(a)1 |
|
37B73
351511 NM_136075.21 NP_609919.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ned-81 |
Protein NED-8 |
74.12(n)
88.16(a) |
|
172910 NM_060316.2 NP_492717.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RUB36 |
NEDD8-like protein RUB3 |
67(a) |
1 ↔ 1 |
1(4045619-4045855) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ubiquitin family protein, putative |
58(a) |
1 ↔ 1 |
10(21091320-21091565) |
ENSEMBL Gene Tree for NEDD8 (if available)
TreeFam Gene Tree for NEDD8 (if available) |
Paralogs
for NEDD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NEDD8 gene
14 SIMAP similar genes for NEDD8 using alignment to 3 protein entries: NEDD8_HUMAN (see all proteins):NEDD8-MDP1 UBC UBBP4 UBB RPS27A DKFZp434K0435
UBA52 BAG6 ZFAND4 RAD23B UBTD2 UBL4A
UHRF2 RAD23A
NEDD8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NEDD8
PGOHUM00000244778
|
Genomic Variants
for NEDD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NEDD8 (24686057 - 24701660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEDD8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEDD8 |
|
Disorders
/ Diseases
for NEDD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEDD8 for disorders About GeneDecksing
OMIM gene information: 603171
OMIM disorders: --
16  diseases for NEDD8: About MalaCardscrimean-congo hemorrhagic fever renal clear cell carcinoma oral squamous cell carcinoma squamous cell carcinoma
hemorrhagic fever parkinson's disease renal cell carcinoma lipodystrophy
alzheimer's disease blindness carcinoma prostate cancer
breast cancer hypoxia prostatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for NEDD8:Crimean-Congo hemorrhagic fever 3 Novoseek disease relationships for NEDD8 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| parkinson disease |
15.5 |
1 |
12533840 (1) |
| alzheimers disease |
0.569 |
1 |
12533840 (1) |
| tumors |
0 |
4 |
10318914 (2), 10585493 (1), 15242646 (1) |
Export disorders for NEDD8 gene to outside databases
|
Publications
for NEDD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NEDD8 gene, integrated from 9 sources (see all 207):
(articles sorted by number of sources associating them with NEDD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PubMed id 9353319)1, 2, 3, 9 Kamitani T.... Yeh E.T.H. (1997)
- NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression. (PubMed id 11259415)1, 2, 9 Kito K.... Kamitani T. (2001)
- Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. (PubMed id 9857030)1, 2, 9 Whitby F.G.... Hill C.P. (1998)
- Cleavage of the C-terminus of NEDD8 by UCH-L3. (PubMed id 9790970)1, 2, 9 Wada H.... Kamitani T. (1998)
- DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PubMed id 12759363)1, 2, 9 Wu K.... Pan Z.-Q. (2003)
- Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (1999)
- Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PubMed id 15242646)1, 2, 9 Xirodimas D.P.... Lane D.P. (2004)
- Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. (PubMed id 10318914)1, 2, 9 Liakopoulos D.... Pause A. (1999)
- The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PubMed id 14690597)1, 2, 9 Walden H.... Schulman B.A. (2003)
- NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PubMed id 12730221)1, 2, 9 Mendoza H.M....Hay R.T. (2003)
|
External Searches for NEDD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEDD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEDD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NEDD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NEDD8 gene:
Search GeneIP for patents involving NEDD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NEDD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for NEDD8 | | OriGene shRNA RFP for NEDD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEDD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEDD8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NEDD8 | | OriGene 3'-UTR Clone for NEDD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NEDD8 | | OriGene Custom Protein Services for NEDD8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEDD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEDD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD8 |
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| | Antibodies & Assays for NEDD8 |
| | | | Search Tocris compounds for NEDD8 |
| |  |  |  |  | | | | | | Recombinant Protein for NEDD8 |
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 | | | NEDD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for NEDD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD8 |
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