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Aliases for NEDD8 Gene

Aliases for NEDD8 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 2 3 5
  • Ubiquitin-Like Protein Nedd8 3 4
  • Neddylin 3 4
  • NEDD-8 3 4
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8 4

External Ids for NEDD8 Gene

Previous GeneCards Identifiers for NEDD8 Gene

  • GC14M022058
  • GC14M018473
  • GC14M022674
  • GC14M022676
  • GC14M023755
  • GC14M024686
  • GC14M004801

Summaries for NEDD8 Gene

GeneCards Summary for NEDD8 Gene

NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8) is a Protein Coding gene. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Deubiquitination. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is RPS27A.

UniProtKB/Swiss-Prot for NEDD8 Gene

  • Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Wiki entry for NEDD8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD8 Gene

Genomics for NEDD8 Gene

Regulatory Elements for NEDD8 Gene

Enhancers for NEDD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -195.3 -195292 10.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CBLN3 KHNYN MDP1 NYNRIN ENSG00000259321 TINF2 ADCY4 NEDD8 NEDD8-MDP1 SDR39U1
GH14G024270 1.5 FANTOM5 ENCODE 11.7 -40.4 -40372 5.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DHRS1 TINF2 LTB4R KHNYN NEDD8 NEDD8-MDP1 NOP9 GMPR2 ENSG00000254692 CHMP4A
GH14G024277 1.4 FANTOM5 Ensembl ENCODE 12.2 -47.1 -47147 5.2 CTCF PKNOX1 USF1 NFIB MAX EBF1 RAD21 RELA RFX5 NFYB DHRS1 TINF2 NOP9 LTB4R2 LTB4R CIDEB NEDD8-MDP1 NEDD8 GMPR2 MDP1
GH14G024309 1.3 ENCODE dbSUPER 10.9 -81.3 -81276 8.6 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B DMAP1 YY1 SLC30A9 ZNF207 LTB4R DHRS1 PABPN1 NEDD8-MDP1 NEDD8 CBLN3 KHNYN NYNRIN TGM1 GC14M024319
GH14G024194 1.1 ENCODE 11.5 +36.6 36578 3.5 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 MDP1 REC8 NEDD8-MDP1 NEDD8 TINF2 RNF31 PSME2 PABPN1 TGM1 NFATC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEDD8 on UCSC Golden Path with GeneCards custom track

Promoters for NEDD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066843 54 2001 HDGF PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for NEDD8 Gene

Chromosome:
14
Start:
24,216,851 bp from pter
End:
24,232,454 bp from pter
Size:
15,604 bases
Orientation:
Minus strand

Genomic View for NEDD8 Gene

Genes around NEDD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD8 Gene

Proteins for NEDD8 Gene

  • Protein details for NEDD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15843-NEDD8_HUMAN
    Recommended name:
    NEDD8
    Protein Accession:
    Q15843
    Secondary Accessions:
    • Q3SXN8
    • Q6LES6

    Protein attributes for NEDD8 Gene

    Size:
    81 amino acids
    Molecular mass:
    9072 Da
    Quaternary structure:
    • Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.

    Three dimensional structures from OCA and Proteopedia for NEDD8 Gene

neXtProt entry for NEDD8 Gene

Post-translational modifications for NEDD8 Gene

  • Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.
  • Ubiquitination at posLast=1111, Lys22, Lys48, Lys54, and posLast=6060
  • Modification sites at PhosphoSitePlus

Other Protein References for NEDD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NEDD8 (NEDD8)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NEDD8

No data available for DME Specific Peptides for NEDD8 Gene

Domains & Families for NEDD8 Gene

Protein Domains for NEDD8 Gene

Suggested Antigen Peptide Sequences for NEDD8 Gene

Graphical View of Domain Structure for InterPro Entry

Q15843

UniProtKB/Swiss-Prot:

NEDD8_HUMAN :
  • Belongs to the ubiquitin family.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with NEDD8: view

No data available for Gene Families for NEDD8 Gene

Function for NEDD8 Gene

Molecular function for NEDD8 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Gene Ontology (GO) - Molecular Function for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15988528
GO:0016791 phosphatase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 15694336
genes like me logo Genes that share ontologies with NEDD8: view
genes like me logo Genes that share phenotypes with NEDD8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEDD8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NEDD8 Gene

Localization for NEDD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD8 Gene

Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9353319
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NEDD8: view

Pathways & Interactions for NEDD8 Gene

genes like me logo Genes that share pathways with NEDD8: view

Pathways by source for NEDD8 Gene

1 GeneGo (Thomson Reuters) pathway for NEDD8 Gene
1 Qiagen pathway for NEDD8 Gene

Gene Ontology (GO) - Biological Process for NEDD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006464 cellular protein modification process TAS 9694792
GO:0006508 proteolysis TAS 9694792
GO:0006511 ubiquitin-dependent protein catabolic process TAS 9353319
GO:0006879 cellular iron ion homeostasis TAS --
genes like me logo Genes that share ontologies with NEDD8: view

No data available for SIGNOR curated interactions for NEDD8 Gene

Drugs & Compounds for NEDD8 Gene

(4) Drugs for NEDD8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for NEDD8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NEDD8: view

Transcripts for NEDD8 Gene

Unigene Clusters for NEDD8 Gene

Neural precursor cell expressed, developmentally down-regulated 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NEDD8

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for NEDD8 Gene

GeneLoc Exon Structure for
NEDD8
ECgene alternative splicing isoforms for
NEDD8

Expression for NEDD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NEDD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD8 Gene

This gene is overexpressed in Amniocyte (10.0) and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEDD8 Gene



Protein tissue co-expression partners for NEDD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEDD8 Gene:

NEDD8

SOURCE GeneReport for Unigene cluster for NEDD8 Gene:

Hs.531064

mRNA Expression by UniProt/SwissProt for NEDD8 Gene:

Q15843-NEDD8_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Evidence on tissue expression from TISSUES for NEDD8 Gene

  • Nervous system(3.5)
  • Lung(3.1)
  • Heart(2.9)
  • Kidney(2.9)
  • Intestine(2.5)
  • Spleen(2.5)
  • Muscle(2.3)
  • Liver(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with NEDD8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NEDD8 Gene

Orthologs for NEDD8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD8 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia NEDD8 34 35
  • 96.71 (n)
cow
(Bos Taurus)
Mammalia NEDD8 34 35
  • 95.06 (n)
-- 35
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nedd8 34
  • 92.59 (n)
mouse
(Mus musculus)
Mammalia Nedd8 34 16 35
  • 92.18 (n)
oppossum
(Monodelphis domestica)
Mammalia NEDD8 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd8 34
  • 79.82 (n)
Str.10937 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2952 34
zebrafish
(Danio rerio)
Actinopterygii nedd8 34 35
  • 81.58 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12683 34
fruit fly
(Drosophila melanogaster)
Insecta Nedd8 36 34 35
  • 75.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007913 34
  • 75 (n)
worm
(Caenorhabditis elegans)
Secernentea ned-8 34 35
  • 74.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RUB1 34 35
  • 60.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F17974g 34
  • 60.53 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL185W 34
  • 60.09 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ned8 34
  • 68.42 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03309 34
  • 67.54 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2781 34
Species where no ortholog for NEDD8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEDD8 Gene

ENSEMBL:
Gene Tree for NEDD8 (if available)
TreeFam:
Gene Tree for NEDD8 (if available)

Paralogs for NEDD8 Gene

Paralogs for NEDD8 Gene

(15) SIMAP similar genes for NEDD8 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NEDD8 Gene

genes like me logo Genes that share paralogs with NEDD8: view

Variants for NEDD8 Gene

Sequence variations from dbSNP and Humsavar for NEDD8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000014354 -- 24,228,452(+) GCTCA(C/T)GGCTG intron-variant
rs1000034305 -- 24,231,642(+) GCAGC(A/G)GTAAC intron-variant, upstream-variant-2KB
rs1000035965 -- 24,218,365(+) GAAGA(A/G)GAGTT intron-variant
rs1000316790 -- 24,231,721(+) AACAC(A/G)CTCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000408551 -- 24,218,000(+) TAGAG(G/T)CTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NEDD8 Gene

Variant ID Type Subtype PubMed ID
esv3633803 CNV loss 21293372

Variation tolerance for NEDD8 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEDD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NEDD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD8 Gene

Disorders for NEDD8 Gene

Relevant External Links for NEDD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEDD8

No disorders were found for NEDD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD8 Gene

Publications for NEDD8 Gene

  1. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PMID: 9353319) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PMID: 15242646) Xirodimas D.P. … Lane D.P. (Cell 2004) 3 4 22 64
  3. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PMID: 12759363) Wu K. … Pan Z.-Q. (J. Biol. Chem. 2003) 3 4 22 64
  4. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PMID: 14690597) Walden H. … Schulman B.A. (Mol. Cell 2003) 3 4 22 64
  5. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PMID: 12730221) Mendoza H.M. … Hay R.T. (J. Biol. Chem. 2003) 3 4 22 64

Products for NEDD8 Gene

  • Addgene plasmids for NEDD8

Sources for NEDD8 Gene

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