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NEDD8 Gene

protein-coding   GIFtS: 64
GCID: GC14M024686

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 81 2
Ubiquitin-Like Protein Nedd82 3
NEDD-82 3
neddylin2
Neddylin3
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 83

External Ids:    HGNC: 77321   Entrez Gene: 47382   Ensembl: ENSG000001295597   OMIM: 6031715   UniProtKB: Q158433   

Export aliases for NEDD8 gene to outside databases

Previous GC identifers: GC14M022058 GC14M018473 GC14M022674 GC14M022676 GC14M023755 GC14M004801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEDD8 Gene:
NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) is a protein-coding gene. Diseases associated with NEDD8 include glomuvenous malformation, and crimean-congo hemorrhagic fever. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843
Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent
attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2
enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus
promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins

Gene Wiki entry for NEDD8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEDD8 gene promoter:
         POU2F1   POU2F1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEDD8 promoter sequence
   Search Chromatin IP Primers for NEDD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

NEDD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024686:  view genomic region     (about GC identifiers)

Start:
24,686,057 bp from pter      End:
24,701,660 bp from pter
Size:
15,604 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843 (See protein sequence)
Recommended Name: NEDD8 precursor  
Size: 81 amino acids; 9072 Da
Subunit: Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53
Selected PDB 3D structures from and Proteopedia for NEDD8 (see all 15):
1NDD (3D)        1R4M (3D)        1R4N (3D)        1XT9 (3D)        2BKR (3D)        2KO3 (3D)    
Secondary accessions: Q3SXN8 Q6LES6

Explore the universe of human proteins at neXtProt for NEDD8: NX_Q15843

Explore proteomics data for NEDD8 at MOPED

Post-translational modifications: 

  • Cleavage of precursor form by UCHL3 or SENP8 is necessary for function1
  • Ubiquitination2 at Lys11, Lys22, Lys48, Lys54, Lys60
  • Modification sites at PhosphoSitePlus

  • See NEDD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006147.1  
    ENSEMBL proteins: 
     ENSP00000250495   ENSP00000380040   ENSP00000448192  
    Reactome Protein details: Q15843

    NEDD8 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals NEDD8 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NEDD8
    Cloud-Clone Corp. Proteins for NEDD8

    NEDD8 Antibody Products:

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    Abcam antibodies for NEDD8
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    ThermoFisher Antibody for NEDD8
    LSBio Antibodies in human, mouse, rat for NEDD8

    NEDD8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for NEDD8
    Cloud-Clone Corp. CLIAs for NEDD8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry Q15843

    ProtoNet protein and cluster: Q15843

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843
    Similarity: Belongs to the ubiquitin family


    NEDD8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEDD8_HUMAN, Q15843
    Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent
    attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2
    enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus
    promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15988528
    GO:0031625ubiquitin protein ligase binding IPI15694336
         
    NEDD8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NEDD8:
     Cell cycle / mitosis defect  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEDD8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEDD8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEDD8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEDD8

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    2 qRT-PCR Assays for microRNAs that regulate NEDD8:
    hsa-miR-532-3p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidNEDD8 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NEDD8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NEDD8 (NM_006156)
    Sino Biological Human cDNA Clone for NEDD8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEDD8_HUMAN, Q15843: Nucleus. Note=Mainly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    NEDD8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEDD8 About   (see all 8)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2TGF-beta receptor signaling activates SMADs
    TGF-beta receptor signaling activates SMADs0.82
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell cycle Regulation of G1 S transition part 1
    Cell cycle Role of SCF complex in cell cycle regulation0.39
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NEDD8
        AHR Pathway

    1 Cell Signaling Technology (CST) Pathway for NEDD8
        Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for NEDD8
        Cell cycle Role of SCF complex in cell cycle regulation

    1 BioSystems Pathway for NEDD8
        p53 pathway


    1 Reactome Pathway for NEDD8
        TGF-beta receptor signaling activates SMADs



    NEDD8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NEDD8: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NEDD8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEDD8 (Q158431, 2, 3 ENSP000002504954) via UniProtKB, MINT, STRING, and/or I2D (see all 284)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL11P629131, 2, 3, ENSP000003636764EBI-716247,EBI-354380 MINT-7294622 MINT-6542674 MINT-6541111 MINT-7294570 I2D: score=2 STRING: ENSP00000363676
    BTRCQ9Y2971, 2, 3, ENSP000003592064EBI-716247,EBI-307461 MINT-4544702 MINT-4544692 I2D: score=3 STRING: ENSP00000359206
    RPS3P233961, 2, 3, ENSP000002785724EBI-716247,EBI-351193 MINT-6542674 MINT-6541160 I2D: score=2 STRING: ENSP00000278572
    RPL9P329692, 3, ENSP000003460224MINT-6542674 I2D: score=1 STRING: ENSP00000346022
    RPL9P7P329692, 3MINT-6542674 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006464cellular protein modification process TAS9694792
    GO:0006508proteolysis TAS9694792
    GO:0006511ubiquitin-dependent protein catabolic process TAS9353319
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    NEDD8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEDD8

    5 Novoseek inferred chemical compound relationships for NEDD8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 52 9 17439941 (1), 18096514 (1), 11675391 (1), 15537541 (1) (see all 8)
    cysteine 30.7 3 18782863 (1), 16980297 (1)
    atp 0 1 12740388 (1)
    steroid 0 1 11818503 (1)
    arginine 0 1 14690597 (1)



    NEDD8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEDD8 gene: 
    NM_006156.2  

    Unigene Cluster for NEDD8:

    Neural precursor cell expressed, developmentally down-regulated 8
    Hs.531064  [show with all ESTs]
    Unigene Representative Sequence: AK125214
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250495(uc001wnn.2) ENST00000396828(uc001wno.2) ENST00000527046
    ENST00000531430 ENST00000560427 ENST00000526430 ENST00000524927 ENST00000533242(uc001wnp.2)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat NEDD8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NEDD8:
    hsa-miR-532-3p hsa-miR-1322
    SwitchGear 3'UTR luciferase reporter plasmidNEDD8 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEDD8
      QuantiTect SYBR Green Assays in human, mouse, rat NEDD8
      QuantiFast Probe-based Assays in human, mouse, rat NEDD8

    Additional mRNA sequence: 

    AK125214.1 BC104200.1 BC104201.1 BC104664.1 CR407662.1 D23662.1 

    13 DOTS entries:

    DT.95225587  DT.40284385  DT.455838  DT.99950778  DT.40115876  DT.87000939  DT.100845971  DT.40290821 
    DT.100042140  DT.91666339  DT.91861974  DT.100042141  DT.91915964 

    Selected AceView cDNA sequences (see all 554):

    BU736752 CD519487 BQ941018 BM553019 BC046912 NM_014169 BX111053 AI571450 
    BG756801 AI261855 BM565531 AI128579 AI718962 BC038290 AI810294 AA337516 
    BC009495 BF795492 BQ652841 BQ669080 BU856948 AK092821 BM766895 BM458809 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NEDD8    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:              -     -     -     -                 -               
    SP2:                          -     -                 -               
    SP3:              -     -     -     -                                 
    SP4:              -                                                   
    SP5:                                                                  


    ECgene alternative splicing isoforms for NEDD8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEDD8 expression in normal human tissues (normalized intensities)      NEDD8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTACAAA
    NEDD8 Expression
    About this image


    NEDD8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    NEDD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEDD8 Protein Expression

    Genevestigator expression for NEDD8

    SOURCE GeneReport for Unigene cluster: Hs.531064

    UniProtKB/Swiss-Prot: NEDD8_HUMAN, Q15843
    Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and
    leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including NEDD8: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NEDD8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEDD8 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd81 , 5 neural precursor cell expressed, developmentally down-regulated more1, 5 92.18(n)1
    98.77(a)1
      14 (28.19 cM)5
    180021  NM_008683.31  NP_032709.11 
     556622675 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.29522 Xenopus laevis transcribed sequence with strong similarity more 77.98(n)    48024167 
    zebrafish
    (Danio rerio)
    Actinopterygii nedd82 neural precursor cell expressed, developmentally down-regulated more 81.39(n)   368667  BC055645.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nedd81 , 3 protein degradation tagging3
    Nedd81
    89(a)3
    75.53(n)1
    89.87(a)1
      37B73
    351511  NM_136075.21  NP_609919.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ned-81 ned-8 74.12(n)
    88.16(a)
      172910  NM_060316.3  NP_492717.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RUB11 RUB1 60.61(n)
    58.44(a)
      851717   NP_010423.4 


    ENSEMBL Gene Tree for NEDD8 (if available)
    TreeFam Gene Tree for NEDD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEDD8 gene
    15 SIMAP similar genes for NEDD8 using alignment to 3 protein entries:     NEDD8_HUMAN (see all proteins):
    NEDD8-MDP1    UBC    UBBP4    UBB    RPS27A    DKFZp434K0435
    UBA52    UbC    BAG6    ZFAND4    RAD23B    UBTD2
    UBL4A    UHRF2    RAD23A

    NEDD8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NEDD8
    PGOHUM00000244778


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEDD8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603171    OMIM disorders: --

    Selected diseases for NEDD8 (see all 21):    About MalaCards
    glomuvenous malformation    crimean-congo hemorrhagic fever    renal clear cell carcinoma    lipodystrophy
    hemorrhagic fever    parkinson's disease    oral squamous cell carcinoma    blindness
    hypoxia    alzheimer's disease    renal cell carcinoma    squamous cell carcinoma
    prostatitis    prostate cancer    hiv-1    breast cancer
    malaria    myeloma    neuronitis    melanoma

    1 disease from the University of Copenhagen DISEASES database for NEDD8:
    Crimean-Congo hemorrhagic fever

    NEDD8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for NEDD8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 15.5 1 12533840 (1)
    alzheimers disease 0.569 1 12533840 (1)
    tumors 0 4 10318914 (2), 10585493 (1), 15242646 (1)


    Export disorders for NEDD8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEDD8 gene, integrated from 10 sources (see all 230):
    (articles sorted by number of sources associating them with NEDD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. (PubMed id 9353319)1, 2, 3, 9 Kamitani T.... Yeh E.T.H. (J. Biol. Chem. 1997)
    2. NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression. (PubMed id 11259415)1, 2, 9 Kito K.... Kamitani T. (J. Biol. Chem. 2001)
    3. Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. (PubMed id 9857030)1, 2, 9 Whitby F.G.... Hill C.P. (J. Biol. Chem. 1998)
    4. Cleavage of the C-terminus of NEDD8 by UCH-L3. (PubMed id 9790970)1, 2, 9 Wada H.... Kamitani T. (Biochem. Biophys. Res. Commun. 1998)
    5. DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1. (PubMed id 12759363)1, 2, 9 Wu K.... Pan Z.-Q. (J. Biol. Chem. 2003)
    6. Covalent modification of all members of human cullin family proteins by NEDD8. (PubMed id 10597293)1, 2, 9 Hori T.... Tanaka K. (Oncogene 1999)
    7. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (PubMed id 15242646)1, 2, 9 Xirodimas D.P.... Lane D.P. (Cell 2004)
    8. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. (PubMed id 10318914)1, 2, 9 Liakopoulos D.... Pause A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. (PubMed id 14690597)1, 2, 9 Walden H.... Schulman B.A. (Mol. Cell 2003)
    10. NEDP1, a highly conserved cysteine protease that deneddylates cullins. (PubMed id 12730221)1, 2, 9 Mendoza H.M....Hay R.T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4738 HGNC: 7732 AceView: NEDD8 Ensembl:ENSG00000129559 euGenes: HUgn4738
    ECgene: NEDD8 H-InvDB: NEDD8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NEDD8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NEDD8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEDD8 gene:
    Search GeneIP for patents involving NEDD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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