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Aliases for NEDD4 Gene

Aliases for NEDD4 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase 2 3
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 3 4
  • Cell Proliferation-Inducing Gene 53 Protein 3 4
  • Receptor-Potentiating Factor 1 2 3
  • NEDD4-1 3 4
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 2
  • E3 Ubiquitin-Protein Ligase NEDD4 3
  • EC 6.3.2.- 4
  • KIAA0093 4
  • EC 6.3.2 64
  • NEDD-4 4
  • RPF1 3

External Ids for NEDD4 Gene

Summaries for NEDD4 Gene

GeneCards Summary for NEDD4 Gene

NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include keloid formation. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin binding. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for NEDD4 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.

Gene Wiki entry for NEDD4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD4 Gene

Genomics for NEDD4 Gene

Genomic Location for NEDD4 Gene

Start:
55,826,917 bp from pter
End:
55,993,746 bp from pter
Size:
166,830 bases
Orientation:
Minus strand

Genomic View for NEDD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NEDD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD4 Gene

Regulatory Elements for NEDD4 Gene

Proteins for NEDD4 Gene

  • Protein details for NEDD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46934-NEDD4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NEDD4
    Protein Accession:
    P46934
    Secondary Accessions:
    • A1KY35
    • A6ND72
    • A7MD29
    • B4E2R7
    • B7ZM59
    • B7ZM60
    • B9EGN5
    • D6RF89

    Protein attributes for NEDD4 Gene

    Size:
    1319 amino acids
    Molecular mass:
    149114 Da
    Quaternary structure:
    • Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains, to neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, TMEPAI and PRRG2 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable according to PubMed:18562292. Interacts with viral proteins that contain a late- budding motif P-P-P-Y. This interaction is essential for viral particle budding of a lot of retroviruses, like HTLV-1 Gag and MLV Gag. Interacts (via C2 domain) with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK; the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4. Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via C-terminus). Interacts with OTUD7B. Interacts with ISG15. Interacts (via WW domain) with RAPGEF2; this interaction leads to ubiquitination and degradation via the proteasome pathway.
    Miscellaneous:
    • A cysteine residue is required for ubiquitin-thioester formation
    SequenceCaution:
    • Sequence=BAA07655.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NEDD4 Gene

    Alternative splice isoforms for NEDD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD4 Gene

Proteomics data for NEDD4 Gene at MOPED

Post-translational modifications for NEDD4 Gene

Domains for NEDD4 Gene

Protein Domains for NEDD4 Gene

UniProtKB/Swiss-Prot:

NEDD4_HUMAN
Domain:
  • The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2.:
    • P46934
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • P46934
  • Contains 4 WW domains.:
    • P46934
genes like me logo Genes that share domains with NEDD4: view

No data available for Gene Families for NEDD4 Gene

Function for NEDD4 Gene

Molecular function for NEDD4 Gene

GENATLAS Biochemistry: neural precursor cell expressed gene 4,developmentally down-regulated 4,expressed in embryonic and adult tissues,homolog to ubiquitin-protein ligases (E3) and to yeast RSP5
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by NDFIP1- and NDFIP2-binding.
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.

Enzyme Numbers (IUBMB) for NEDD4 Gene

Gene Ontology (GO) - Molecular Function for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 10642508
GO:0016874 ligase activity IEA --
GO:0019871 sodium channel inhibitor activity IDA 10642508
GO:0019904 protein domain specific binding IPI 12907594
genes like me logo Genes that share ontologies with NEDD4: view
genes like me logo Genes that share phenotypes with NEDD4: view

Animal Models for NEDD4 Gene

MGI Knock Outs for NEDD4:

miRNA for NEDD4 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for NEDD4 Gene

Localization for NEDD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD4 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. {ECO:0000250, ECO:0000269 PubMed:18819914}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEDD4 Gene COMPARTMENTS Subcellular localization image for NEDD4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3
nucleus 3
endosome 2
lysosome 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex ISS --
GO:0000785 chromatin IDA 17996703
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 12796489
GO:0005794 Golgi apparatus IDA 16118794
genes like me logo Genes that share ontologies with NEDD4: view

Pathways for NEDD4 Gene

genes like me logo Genes that share pathways with NEDD4: view

Pathways by source for NEDD4 Gene

UniProtKB/Swiss-Prot P46934-NEDD4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for NEDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0002250 adaptive immune response IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0003197 endocardial cushion development IEA --
GO:0006513 protein monoubiquitination IEA --
genes like me logo Genes that share ontologies with NEDD4: view

Compounds for NEDD4 Gene

(4) HMDB Compounds for NEDD4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(4) Novoseek inferred chemical compound relationships for NEDD4 Gene

Compound -log(P) Hits PubMed IDs
sodium 47.5 4
alanine 9.49 1
calcium 0 7
cysteine 0 1
genes like me logo Genes that share compounds with NEDD4: view

Transcripts for NEDD4 Gene

Unigene Clusters for NEDD4 Gene

Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for NEDD4 Gene

GeneLoc Exon Structure for
NEDD4
ECgene alternative splicing isoforms for
NEDD4

Expression for NEDD4 Gene

mRNA expression in normal human tissues for NEDD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NEDD4 Gene

This gene is overexpressed in Muscle - Skeletal (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEDD4 Gene

SOURCE GeneReport for Unigene cluster for NEDD4 Gene Hs.1565

genes like me logo Genes that share expressions with NEDD4: view

Orthologs for NEDD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NEDD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NEDD4 36
  • 92.05 (n)
  • 91.81 (a)
NEDD4 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NEDD4 36
  • 92.09 (n)
  • 92.04 (a)
NEDD4 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nedd4 16
Nedd4 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEDD4 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEDD4 37
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NEDD4 36
  • 73 (n)
  • 69.73 (a)
NEDD4 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 89 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd4 36
  • 69.12 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii NEDD4 37
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nedd4 37
  • 41 (a)
OneToMany
Nedd4 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea Y92H12A.2 37
  • 48 (a)
OneToMany
Y92H12A.2 38
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 37
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1579 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
Species with no ortholog for NEDD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NEDD4 Gene

ENSEMBL:
Gene Tree for NEDD4 (if available)
TreeFam:
Gene Tree for NEDD4 (if available)

Paralogs for NEDD4 Gene

Paralogs for NEDD4 Gene

Selected SIMAP similar genes for NEDD4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NEDD4: view

Variants for NEDD4 Gene

Sequence variations from dbSNP and Humsavar for NEDD4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs906811 -- 55,937,349(-) TGTCA(C/T)TTATA intron-variant
rs925257 -- 55,937,038(-) AGGAG(G/T)GTGGA intron-variant
rs952532 -- 55,926,068(-) ACATA(A/C/T)GTATA intron-variant
rs952533 -- 55,926,027(-) ACATA(C/T)GTATA intron-variant
rs967128 -- 55,959,485(-) TATTC(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD4 Gene

Variant ID Type Subtype PubMed ID
nsv833017 CNV Loss 17160897
nsv528617 CNV Loss 19592680
esv2749725 CNV Deletion 23290073
nsv819986 CNV Loss 19587683
nsv1543 CNV Insertion 18451855
nsv509571 CNV Insertion 20534489
nsv904245 CNV Loss 21882294
dgv319n27 CNV Loss 19166990

Relevant External Links for NEDD4 Gene

HapMap Linkage Disequilibrium report
NEDD4

Disorders for NEDD4 Gene

(1) MalaCards Diseases for NEDD4 Gene

Search for NEDD4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NEDD4 Gene

(6) Novoseek inferred disease relationships for NEDD4 Gene

Disease -log(P) Hits PubMed IDs
liddles syndrome 90.5 12
pseudohypoaldosteronism 66 1
charcot-marie-tooth disease 33.4 2
immunodeficiency 4.31 2
tumors 0 2

Relevant External Links for NEDD4

Genetic Association Database (GAD)
NEDD4
Human Genome Epidemiology (HuGE) Navigator
NEDD4
genes like me logo Genes that share disorders with NEDD4: view

No data available for UniProtKB/Swiss-Prot for NEDD4 Gene

Publications for NEDD4 Gene

  1. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. (PMID: 9073511) Kumar S. … Jenkins N.A. (Genomics 1997) 2 3 23
  2. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. (PMID: 11598133) Pham N. … Rotin D. (J. Biol. Chem. 2001) 3 4 23
  3. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PMID: 14581525) Bouamr F. … Goff S.P. (J. Virol. 2003) 3 4 23
  4. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. (PMID: 15060076) Murdaca J. … Giorgetti-Peraldi S. (J. Biol. Chem. 2004) 3 23
  5. Cloning and characterization of N4WBP5A, an inducible, cyclosporine- sensitive, Nedd4-binding protein in human T lymphocytes. (PMID: 12796489) Cristillo A.D. … Bierer B.E. (J. Biol. Chem. 2003) 3 23

Products for NEDD4 Gene

  • Addgene plasmids for NEDD4

Sources for NEDD4 Gene

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