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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEDD4 Gene

protein-coding   GIFtS: 71
GCID: GC15M056119

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3
Ubiquitin Protein Ligase1 2
     RPF12
Receptor-Potentiating Factor 11 2     E3 Ubiquitin-Protein Ligase NEDD42
Cell Proliferation-Inducing Gene 53 Protein2 3     EC 6.3.2.-3
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 42 3     KIAA00933
NEDD4-12 3     NEDD-43
Neural Precursor Cell Expressed, Developmentally Down-Regulated 41     EC 6.3.28

External Ids:    HGNC: 77271   Entrez Gene: 47342   Ensembl: ENSG000000698697   OMIM: 6022785   UniProtKB: P469343   

Export aliases for NEDD4 gene to outside databases

Previous GC identifers: GC15M051677 GC15M049166 GC15M053698 GC15M053835 GC15M053906 GC15M032943


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NEDD4 Gene: 
NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with NEDD4 include pseudohypoaldosteronism type 1, and liddle syndrome, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Interferon Signaling. GO annotations related to this gene include ubiquitin binding and ubiquitin-protein ligase activity. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading
to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at
multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1,
leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link
between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable.
Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of
a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2

Gene Wiki entry for NEDD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEDD4 gene promoter:
         AREB6   NF-AT4   NF-AT2   FOXF2   NF-AT3   Nkx2-5   LCR-F1   NF-kappaB1   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEDD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEDD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q

NEDD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M056119:  view genomic region     (about GC identifiers)

Start:
56,119,120 bp from pter      End:
56,285,944 bp from pter
Size:
166,825 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NEDD4  
Size: 1319 amino acids; 149114 Da
Subunit: Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains,
to neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, TMEPAI
and PRRG2 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein
ligase and may induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable
according to PubMed:18562292. Interacts with viral proteins that contain a late- budding motif P-P-P-Y. This
interaction is essential for viral particle budding of a lot of retroviruses, like HTLV-1 Gag and MLV Gag.
Interacts (via C2 domain) with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK;
the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4.
Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via
C-terminus). Interacts with OTUD7B
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R
internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the
sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAA07655.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/7 PDB 3D structures from and Proteopedia for NEDD4 (see all 7):
2KPZ (3D)        2KQ0 (3D)        2XBB (3D)        2XBF (3D)        3B7Y (3D)        4BBN (3D)    
Secondary accessions: A1KY35 A6ND72 A7MD29 B4E2R7 B7ZM59 B7ZM60 B9EGN5 D6RF89
Alternative splicing: 4 isoforms:  P46934-1   P46934-2   P46934-3   P46934-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD4: NX_P46934

Explore proteomics data for NEDD4 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46934

  • 4/10 DME Specific Peptides for NEDD4 (P46934) (see all 10)
     KNKKEYI  PLPPGWE  TQWEDPR  HLSYFKF 

    NEDD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NEDD4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001271267.1  NP_001271268.1  NP_001271269.1  NP_006145.2  NP_940682.2  

    ENSEMBL proteins: 
     ENSP00000422455   ENSP00000426051   ENSP00000345530   ENSP00000424827   ENSP00000410613  
     ENSP00000422705   ENSP00000424471   ENSP00000421047  
    Reactome Protein details: P46934
    Human Recombinant Protein Products for NEDD4: 
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    Novus Biologicals NEDD4 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEDD4 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ISS--
    GO:0000785chromatin IDA17996703
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IDA12796489
    GO:0005794Golgi apparatus IDA16118794

    NEDD4 for ontologies           About GeneDecksing



    NEDD4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD4
    R&D Systems Antibodies for NEDD4
    Cell Signaling Technology (CST) Antibodies for NEDD4  (NEDD4 iso4)
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    LSBio Antibodies in human, mouse, rat for NEDD4 

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    Cloud-Clone Corp. ELISAs for NEDD4 
    Cloud-Clone Corp. CLIAs for NEDD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000569 HECT
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry P46934

    ProtoNet protein and cluster: P46934

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Domain: The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2 (By similarity)
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    NEDD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEDD4_HUMAN, P46934
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading
    to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at
    multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1,
    leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link
    between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable.
    Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of
    a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and
    arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding (By similarity)

         Genatlas biochemistry entry for NEDD4:
    neural precursor cell expressed gene 4,developmentally down-regulated 4,expressed in embryonic and adult
    tissues,homolog to ubiquitin-protein ligases (E3) and to yeast RSP5

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA17996703
    GO:0005515protein binding IPI10642508
    GO:0019871sodium channel inhibitor activity IDA10642508
    GO:0019904protein domain specific binding IPI12907594
    GO:0031698beta-2 adrenergic receptor binding IDA18544533
         
    NEDD4 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Nedd4):
     cardiovascular system  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  nervous system 

    NEDD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NEDD4: Nedd4tm1Bros Nedd4tm2Bros

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NEDD4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NEDD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEDD4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEDD4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEDD4:
    hsa-let-7b (MIRT001612)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEDD4
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate NEDD4 (see all 53):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNEDD4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for NEDD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NEDD4 (NM_198400)
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                         Customized lentivirus expression plasmids for stable overexpression of NEDD4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NEDD4 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    5PIP3 activates AKT signaling
    Signaling by ERBB40.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NEDD4
        Common schema of ubiquitination
    G-protein signaling Rap1A regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NEDD4
        Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for NEDD4
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for NEDD4
        G-protein signaling Rap1A regulation pathway
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    4 BioSystems Pathways for NEDD4
        Proteasome Degradation
    ErbB4 signaling events
    Presenilin action in Notch and Wnt signaling
    Signaling events mediated by VEGFR1 and VEGFR2

    1 Sino Biological Pathway for NEDD4 
        Notch Signaling Pathway

    5/11        Reactome Pathways for NEDD4 (see all 11)
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Adaptive Immune System
    Downregulation of ERBB4 signaling
    Antigen processing: Ubiquitination & Proteasome degradation


    3         Kegg Pathways  (Kegg details for NEDD4):
        Ubiquitin mediated proteolysis
    Endocytosis
    Epstein-Barr virus infection

    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Pathway: Protein modification; protein ubiquitination


    NEDD4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEDD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/176 Interacting proteins for NEDD4 (P469341, 2, 3 ENSP000003455304) via UniProtKB, MINT, STRING, and/or I2D (see all 176)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1P113622, 3, ENSP000003802804MINT-8290015 MINT-8290063 MINT-8290402 MINT-8289950 MINT-8290027 MINT-8290322 MINT-8290383 MINT-8290051 MINT-8290003 MINT-8290283 MINT-8290560 MINT-8289975 MINT-8290365 MINT-8290238 MINT-8290346 MINT-8289991 MINT-8290605 MINT-8290431 MINT-8290302 MINT-8290170 MINT-8290196 MINT-8292601 MINT-8290629 MINT-8290156 MINT-8290039 MINT-8290263 I2D: score=2 STRING: ENSP00000380280
    SCNN1AP370882, 3, ENSP000002289164MINT-14025 MINT-16750 I2D: score=4 STRING: ENSP00000228916
    LAPTM5Q135712, 3, ENSP000002945074MINT-62181 I2D: score=3 STRING: ENSP00000294507
    PTENP604841, 3, ENSP000003610214EBI-726944,EBI-696162 I2D: score=3 STRING: ENSP00000361021
    SCNN1GP511702, 3, ENSP000003000614MINT-17641 I2D: score=3 STRING: ENSP00000300061
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0002250adaptive immune response IEA--
    GO:0003151outflow tract morphogenesis IEA--
    GO:0003197endocardial cushion development IEA--
    GO:0006513protein monoubiquitination IEA--

    NEDD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEDD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NEDD4

    4 HMDB Compounds for NEDD4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    4 Novoseek inferred chemical compound relationships for NEDD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 47.5 4 12908109 (1), 11323714 (1), 15123669 (1), 11840194 (1)
    alanine 9.49 1 11352919 (1)
    calcium 0 9 20172859 (3), 10720933 (1), 9073511 (1), 9593687 (1) (see all 5)
    cysteine 0 2 9990509 (1)

    Search CenterWatch for drugs/clinical trials and news about NEDD4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NEDD4 gene (5 alternative transcripts): 
    NM_001284338.1  NM_001284339.1  NM_001284340.1  NM_006154.3  NM_198400.3  

    Unigene Cluster for NEDD4:

    Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    Hs.1565  [show with all ESTs]
    Unigene Representative Sequence: AL832063
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508871 ENST00000503468 ENST00000338963(uc002adi.3) ENST00000508342(uc010ugj.2 uc002adj.3 uc010bfm.3 uc002adk.3)
    ENST00000435532(uc002adl.3) ENST00000506154 ENST00000502612 ENST00000514893
    ENST00000507063 ENST00000513957 ENST00000508075 ENST00000557845
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD4
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    Additional mRNA sequence: 

    AK304394.1 AK307541.1 AL832063.1 AL832359.1 AL833293.1 AL833300.1 AY550969.1 BC035707.1 
    BC047035.1 BC136605.1 BC144284.1 BC144285.1 BC152452.1 BC152562.1 D42055.1 

    13 DOTS entries:

    DT.100817363  DT.100817367  DT.100029237  DT.100029236  DT.100723524  DT.121062220  DT.121062254  DT.75178697 
    DT.91745966  DT.92425712  DT.102825738  DT.443258  DT.91925363 

    24/171 AceView cDNA sequences (see all 171):

    AI094191 BU521067 AA703450 AL599509 AA434546 CB115697 BM787575 AI824310 
    AA362040 AI457332 AI208374 BX281486 AA441995 AI862157 AW771306 H57920 
    AA442206 BG492543 BM458314 AV703688 BU165030 CA413788 CB105544 CB105513 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NEDD4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -           -     -     -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                              -     -     -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:              -     -                           


    ECgene alternative splicing isoforms for NEDD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEDD4 expression in normal human tissues (normalized intensities)      NEDD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAAGCAA
    NEDD4 Expression
    About this image


    NEDD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Surface Ectoderm (Integumentary System)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Surface Ectoderm
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             limb/forelimb   
     
     Ectoderm (Gastrulation Derivatives)
             Surface Ectoderm Cells Surface Ectoderm
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See NEDD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEDD4

    SOURCE GeneReport for Unigene cluster: Hs.1565
        SABiosciences Expression via Pathway-Focused PCR Array including NEDD4: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NEDD4 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd41 , 5 neural precursor cell expressed, developmentally down-regulated more1, 5 84.42(n)1
    88.19(a)1
      9 (40.08 cM)5
    179991  NM_010890.31  NP_035020.21 
     726625575 
    chicken
    (Gallus gallus)
    Aves NEDD41 neural precursor cell expressed, developmentally down-regulated more 80.46(n)
    83.54(a)
      415406  XM_413791.3  XP_413791.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    47(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039627(1019-5662)
    GL344463.1(20622-34712)
    zebrafish
    (Danio rerio)
    Actinopterygii nedd4a1 neural precursor cell expressed, developmentally down-regulated more 65.32(n)
    70.05(a)
      619412  NM_001034186.1  NP_001029358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nedd41 , 3 protein ubiquitination
    ubiquitin-protein ligase3
    CG42279-PE1
    50(a)3
    54.61(n)1
    54.27(a)1
      399581  NM_140736.21  NP_648993.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12A.21 , 3 Protein Y92H12A.21 55(a)3
    59.04(n)1
    60.11(a)1
      I(1543634-1555890)3
    1717191  NM_058464.51  NP_490865.31 


    ENSEMBL Gene Tree for NEDD4 (if available)
    TreeFam Gene Tree for NEDD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEDD4 gene
    HERC12  NEDD4L2  HECW22  HERC22  HECTD32  WWP22  HECW12  SMURF22  
    SMURF12  HUWE12  WWP12  ITCH2  
    12 SIMAP similar genes for NEDD4 using alignment to 5 protein entries:     NEDD4_HUMAN (see all proteins):
    DKFZp564H223    HECW1    HUWE1    SMURF2    WWP2    DKFZp564G092
    SMURF1    NEDD4L    ITCH    WWP1    HECTD1    HECTD2

    NEDD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3602 SNPs in NEDD4 are shown (see all 3602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364724
    A breast cancer sample4--see VAR_0364722 Y H mis40--------
    rs1121130221,2
    F--56118695(+) GTGGGC/TGGGAG 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1439674201,2
    C--56118740(+) GCCTGA/GGAGGA 2 -- ds50010--------
    rs1841475171,2
    --56118781(+) CACTCC/TGAACT 2 -- ds50010--------
    rs1164100821,2
    F--56118905(+) TGGCTA/GTTTCA 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1486609351,2
    --56118925(+) AGACTG/TATGCA 2 -- ds50010--------
    rs797862601,2
    C--56118932(+) TGCAAG/TACGAC 2 -- ds50010--------
    rs787777281,2
    F--56118980(+) AGTTTA/GTAATC 2 -- ds50010--------
    rs1884275141,2
    --56119029(+) AAAATG/TTAACG 2 -- ds50010--------
    rs1404094041,2
    --56119227(+) TGATAC/TATATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NEDD4 (56119120 - 56285944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NEDD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749725CNV Deletion23290073
    nsv1543CNV Insertion18451855
    nsv509571CNV Insertion20534489
    dgv319n27CNV Loss19166990
    nsv833017CNV Loss17160897
    nsv819986CNV Loss19587683
    nsv528617CNV Loss19592680
    nsv904245CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602278    OMIM disorders: --

    20/25 diseases for NEDD4 (see all 25):    About MalaCards
    pseudohypoaldosteronism type 1    liddle syndrome    pseudohypoaldosteronism    charcot-marie-tooth disease
    tooth disease    human t-cell leukemia virus type 1    keloids    spinocerebellar ataxia
    prostate cancer, progression of    gout    non-small cell lung carcinoma    conjunctivitis
    t-cell leukemia    herpes simplex    ataxia    chronic lymphocytic leukemia
    prostate cancer    leukemia    hypertension    sarcoma

    1 disease from the University of Copenhagen DISEASES database for NEDD4:
    Pseudohypoaldosteronism

    NEDD4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for NEDD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liddles syndrome 90.5 13 10074483 (3), 10720933 (2), 8665844 (2), 9792722 (2) (see all 7)
    pseudohypoaldosteronism 66 1 15547682 (1)
    charcot-marie-tooth disease 33.4 2 15776429 (1), 16118794 (1)
    immunodeficiency 4.31 2 15126635 (1), 20164219 (1)
    tumors 0 2 9593687 (1), 16118794 (1)
    cancer 0 2 9990509 (1)

    Genetic Association Database (GAD): NEDD4
    Human Genome Epidemiology (HuGE) Navigator: NEDD4 (4 documents)

    Export disorders for NEDD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEDD4 gene, integrated from 9 sources (see all 255):
    (articles sorted by number of sources associating them with NEDD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. (PubMed id 9073511)1, 3, 9 Kumar S....Jenkins N.A. (1997)
    2. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)1, 2, 9 Bouamr F.... Goff S.P. (2003)
    3. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. (PubMed id 21399620)1, 2 Maspero E.... Polo S. (2011)
    4. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. (PubMed id 21765395)1, 2 Persaud A.... Rotin D. (2011)
    5. A genome-wide association study identifies four susce ptibility loci for keloid in the Japanese population. (PubMed id 20711176)1, 4 Nakashima M....Zembutsu H. (2010)
    6. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 c ontrols neurite development. (PubMed id 20159449)1, 2 Kawabe H....Brose N. (2010)
    7. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK an d regulates epidermal growth factor (EGF)-induced degradation of EGF receptor a nd ACK. (PubMed id 20086093)1, 2 Lin Q....Yang W. (2010)
    8. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24 .1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)1, 4 Crowther-Swanepoel D....Houlston R.S. (2010)
    9. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. (PubMed id 17218260)1, 2 Wang X.... Jiang X. (2007)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4734 HGNC: 7727 AceView: NEDD4 Ensembl:ENSG00000069869 euGenes: HUgn4734
    ECgene: NEDD4 Kegg: 4734 H-InvDB: NEDD4

    (According to HUGE)
    About This Section
    HUGE: KIAA0093

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEDD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NEDD4 gene:
    Search GeneIP for patents involving NEDD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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