Aliases for NEDD4 Gene
- Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase 2 3 5
- Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 4 3 4
- Cell Proliferation-Inducing Gene 53 Protein 3 4
- Receptor-Potentiating Factor 1 2 3
- NEDD4-1 3 4
- Neural Precursor Cell Expressed, Developmentally Down-Regulated 4 2
External Ids for NEDD4 Gene
Previous GeneCards Identifiers for NEDD4 Gene
GeneCards Summary for NEDD4 Gene
NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with NEDD4 include liddle syndrome and gastric cardia adenocarcinoma. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include ligase activity and protein domain specific binding. An important paralog of this gene is AREL1.
UniProtKB/Swiss-Prot for NEDD4 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates Lys-63 in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).