Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NEDD4 Gene

protein-coding   GIFtS: 69
GCID: GC15M056119

neural precursor cell expressed, developmentally down-regulated...

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
 Explore 31 diseases affiliated with
NEDD4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NEDD4    

Aliases
for NEDD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3
Ubiquitin Protein Ligase1 2
     MGC1767051
NEDD4-11 2 3     Neural Precursor Cell Expressed, Developmentally Down-Regulated 41
RPF11 2     E3 Ubiquitin-Protein Ligase NEDD42
KIAA00931 3     Receptor-Potentiating Factor 12
Cell Proliferation-Inducing Gene 53 Protein2 3     EC 6.3.2.-3
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 42 3     EC 6.3.28
NEDD-42 3     

External Ids:    HGNC: 77271   Entrez Gene: 47342   Ensembl: ENSG000000698697   OMIM: 6022785   UniProtKB: P469343   

Export aliases for NEDD4 gene to outside databases

Previous GC identifers: GC15M051677 GC15M049166 GC15M053698 GC15M053835 GC15M053906 GC15M032943


Summaries
for NEDD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the
degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple
sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor
internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN
regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of
ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of
NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates
TNK2 and regulates EGF-induced degradation of EGFR and TNF2

Gene Wiki entry for NEDD4


Genomic Views
for NEDD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEDD4 gene promoter:
         AREB6   NF-AT4   NF-AT2   FOXF2   NF-AT3   Nkx2-5   LCR-F1   NF-kappaB1   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEDD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NEDD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q

NEDD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M056119:  view genomic region     (about GC identifiers)

Start:
 56,119,120 bp from pter      End:
 56,285,944 bp from pter
Size:
 166,825 bases      Orientation:
 minus strand

Proteins
for NEDD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NEDD4  
Size: 1319 amino acids; 149114 Da
Subunit: Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains, to
neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, TMEPAI and PRRG2
(By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein ligase and may
induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable according to
PubMed:18562292. Interacts with viral proteins that contain a late- budding motif P-P-P-Y. This interaction is
essential for viral particle budding of a lot of retroviruses, like HTLV-1 Gag and MLV Gag. Interacts (via C2 domain)
with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK; the interaction is direct,
allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4. Interacts (via WW3 domain) with TNK2;
EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via C-terminus). Interacts with OTUD7B
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization,
remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the
receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAA07655.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from and Proteopedia for NEDD4:
2KPZ (3D)        2KQ0 (3D)        2XBB (3D)        2XBF (3D)        3B7Y (3D)    
Secondary accessions: A1KY35 A6ND72 A7MD29 B4E2R7 B7ZM59 B7ZM60 B9EGN5 D6RF89
Alternative splicing: 4 isoforms:  P46934-1   P46934-2   P46934-3   P46934-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD4: NX_P46934

Post-translational modifications:

  • Auto-ubiquitinated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46934

    • 4/10 DME Specific Peptides for NEDD4 (P46934) (see all 10)
     KNKKEYI  PLPPGWE  TQWEDPR  HLSYFKF 

    NEDD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006145.2  NP_940682.2  

    ENSEMBL proteins: 
     ENSP00000422455   ENSP00000426051   ENSP00000345530   ENSP00000424827   ENSP00000410613  
     ENSP00000422705   ENSP00000424471   ENSP00000421047  
    Reactome Protein details: P46934
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NEDD4
    OriGene Protein Over-expression Lysate (see all 2): NEDD4
    OriGene Custom Protein Services for NEDD4 
    GenScript Custom Purified and Recombinant Proteins Services for NEDD4
    Novus Biologicals NEDD4 Protein
    Novus Biologicals NEDD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NEDD4

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ISS--
    GO:0000785chromatin IDA17996703
    GO:0005624membrane fraction ----
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IDA12796489


    NEDD4 for ontologies           About GeneDecksing



    NEDD4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD4
    R&D Systems Antibodies for NEDD4
    Cell Signaling Technology (CST) Antibodies for NEDD4  (NEDD4 iso4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NEDD4 
    GenScript Custom Superior Antibodies Services for NEDD4
    Novus Biologicals NEDD4 Antibodies
    Search for Antibodies for NEDD4 at Abcam  
    Uscn Antibodies for NEDD4
    ThermoFisher Antibody for NEDD4

    Assay Products for NEDD4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEDD4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEDD4

    Protein Domains /
    Families
    for NEDD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NEDD4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001202 WW_Rsp5_WWP
     IPR000569 HECT

    Graphical View of Domain Structure for InterPro Entry P46934

    ProtoNet protein and cluster: P46934

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Domain: The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2 (By similarity)
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    Function
    for NEDD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a
    thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the
    degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple
    sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor
    internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN
    regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of
    ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of
    NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates
    TNK2 and regulates EGF-induced degradation of EGFR and TNF2
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding (By similarity)

         Genatlas biochemistry entry for NEDD4:
    neural precursor cell expressed gene 4,developmentally down-regulated 4,expressed in embryonic and adult
    tissues,homolog to ubiquitin-protein ligases (E3) and to yeast RSP5

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
    Products:            		miRTarBase miRNAs that target NEDD4:
    hsa-let-7b (MIRT001612)

    OriGene 3'-UTR Clone (see all 2): NEDD4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEDD4
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate NEDD4 (see all 53):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: NEDD4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEDD4 (see all 7)
    OriGene shRNA RFP: NEDD4
    OriGene siRNA: NEDD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NEDD4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NEDD4 (NM_198400)
    Sino Biological Human cDNA Clone for NEDD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NEDD4
    Search LifeMap BioReagents cell lines for NEDD4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI9305852
    GO:0019871sodium channel inhibitor activity IDA10642508
    GO:0019904protein domain specific binding IPI12907594
    GO:0031698beta-2 adrenergic receptor binding IDA18544533


    NEDD4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NEDD4: Nedd4tm1Bros Nedd4tm2Bros
         7 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Nedd4):
     cardiovascular system  cellular  growth/size  hematopoietic system  immune system 
     mortality/aging  nervous system 

    NEDD4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NEDD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4G-protein signaling Rap1A regulation pathway
    		G-protein signaling Rap1A regulation pathway1.00
    		G-protein signaling_Rap1A regulation pathway0.88
    5Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		ISG15 antiviral mechanism0.49
    		Antiviral mechanism by IFN-stimulated genes0.49

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for NEDD4
        Common schema of ubiquitination
    G-protein signaling Rap1A regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NEDD4
        Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for NEDD4
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for NEDD4
        G-protein signaling Rap1A regulation pathway
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    4 BioSystems Pathways for NEDD4 
        Proteasome Degradation
    Presenilin action in Notch and Wnt signaling
    ErbB4 signaling events
    Signaling events mediated by VEGFR1 and VEGFR2

    5/12        Reactome Pathways for NEDD4 (see all 12)
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Polyubiquitination of substrate
    Adaptive Immune System
    Downregulation of ERBB4 signaling


    2         Kegg Pathways  (Kegg details for NEDD4):
        Ubiquitin mediated proteolysis
    Endocytosis

    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Pathway: Protein modification; protein ubiquitination


    NEDD4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEDD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/176 Interacting proteins for NEDD4 (P469341, 2, 3 ENSP000003455304) via UniProtKB, MINT, STRING, and/or I2D (see all 176)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1P113622, 3, ENSP000003802804MINT-8290015 MINT-8290063 MINT-8290402 MINT-8289950 MINT-8290027 MINT-8290322 MINT-8290383 MINT-8290051 MINT-8290003 MINT-8290283 MINT-8290560 MINT-8289975 MINT-8290365 MINT-8290238 MINT-8290346 MINT-8289991 MINT-8290605 MINT-8290431 MINT-8290302 MINT-8290170 MINT-8290196 MINT-8292601 MINT-8290629 MINT-8290156 MINT-8290039 MINT-8290263 I2D: score=2 STRING: ENSP00000380280
    SCNN1AP370882, 3, ENSP000002289164MINT-14025 MINT-16750 I2D: score=4 STRING: ENSP00000228916
    LAPTM5Q135712, 3, ENSP000002945074MINT-62181 I2D: score=3 STRING: ENSP00000294507
    PTENP604841, 3, ENSP000003610214EBI-726944,EBI-696162 I2D: score=3 STRING: ENSP00000361021
    SCNN1GP511702, 3, ENSP000003000614MINT-17641 I2D: score=3 STRING: ENSP00000300061
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IEA--
    GO:0003151outflow tract morphogenesis IEA--
    GO:0003197endocardial cushion development IEA--
    GO:0006513protein monoubiquitination IEA--
    GO:0006622protein targeting to lysosome IDA17116753


    NEDD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NEDD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NEDD4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEDD4

    4 HMDB Compounds for NEDD4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    4 Novoseek chemical compound relationships for NEDD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 47.5 4 12908109 (1), 11323714 (1), 15123669 (1), 11840194 (1)
    alanine 9.49 1 11352919 (1)
    calcium 0 9 20172859 (3), 10720933 (1), 9073511 (1), 9593687 (1) (see all 5)
    cysteine 0 2 9990509 (1)

    Search CenterWatch for drugs/clinical trials and news about NEDD4 

    Transcripts
    for NEDD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NEDD4 gene (2 alternative transcripts): 
    NM_006154.2  NM_198400.2  

    Unigene Cluster for NEDD4:

    Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    Hs.1565  [show with all ESTs]
    Unigene Representative Sequence: AL832063
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508871 ENST00000503468 ENST00000338963(uc002adi.3) ENST00000508342(uc010ugj.2 uc002adj.3 uc010bfm.3 uc002adk.3)
    ENST00000435532(uc002adl.3) ENST00000506154 ENST00000502612 ENST00000514893
    ENST00000507063 ENST00000513957 ENST00000508075 ENST00000557845

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): NEDD4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NEDD4
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate NEDD4 (see all 53):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: NEDD4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEDD4 (see all 7)
    OriGene shRNA RFP: NEDD4
    OriGene siRNA: NEDD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NEDD4 (NM_198400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEDD4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEDD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD4

    Additional cDNA sequence: 

    AK304394.1 AK307541.1 AL832063.1 AL832359.1 AL833293.1 AL833300.1 AY550969.1 BC035707.1 
    BC047035.1 BC136605.1 BC144284.1 BC144285.1 BC152452.1 BC152562.1 D42055.1 

    13 DOTS entries:

    DT.100817363  DT.100817367  DT.100029237  DT.100029236  DT.100723524  DT.121062220  DT.121062254  DT.75178697 
    DT.91745966  DT.92425712  DT.102825738  DT.443258  DT.91925363 

    24/171 AceView cDNA sequences (see all 171):

    BG492543 CB115697 AA703450 AI824310 BU521067 BM458314 AA362040 AI457332 
    AA434546 BX281486 AV703688 AW771306 AA441995 AI862157 AI094191 BU165030 
    BM787575 AL599509 AA442206 AI208374 CA413788 H57920 AI472204 CB106116 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NEDD4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -           -     -     -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                              -     -     -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:              -     -                           


    ECgene alternative splicing isoforms for NEDD4

    Expression
    for NEDD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NEDD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCAAGCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NEDD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NEDD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NEDD4

    SOURCE GeneReport for Unigene cluster: Hs.1565
        SABiosciences Expression via Pathway-Focused PCR Array including NEDD4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEDD4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NEDD4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4

    Orthologs
    for NEDD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NEDD4 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NEDD41 neural precursor cell expressed, developmentally down-regulated more 80.46(n)
    83.54(a)    		   415406  XM_413791.3  XP_413791.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NEDD46
    		 --
    		 30(a)
    		 1 ↔ 1
    		 GL344463.1(20740-34712)
    zebrafish
    (Danio rerio)    		 Actinopterygii nedd4a1 neural precursor cell expressed, developmentally down-regulated more 65.32(n)
    70.05(a)    		   619412  NM_001034186.1  NP_001029358.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nedd41 , 3 protein ubiquitination ubiquitin-protein
    ligase3
    CG42279-PE1    		 50(a)3
    54.61(n)1
    54.27(a)1    		   399581  NM_140736.21  NP_648993.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y92H12A.21 , 3 Protein Y92H12A.21 55(a)3
    59.04(n)1
    60.11(a)1    		   I(1543634-1555890)3
    1717191  NM_058464.51  NP_490865.31 


    ENSEMBL Gene Tree for NEDD4 (if available)
    TreeFam Gene Tree for NEDD4 (if available) 

    Paralogs
    for NEDD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NEDD4 gene
    NEDD4L2  HECW22  HACE12  WWP22  KIAA03172  SMURF22  HECW12  SMURF12  
    ITCH2  WWP12  
    13 SIMAP similar genes for NEDD4 using alignment to 5 protein entries:     NEDD4_HUMAN (see all proteins):
    DKFZp564H223    WWP2    HECW1    HUWE1    SMURF2    DKFZp564G092
    SMURF1    NEDD4L    ITCH    WWP1    HECTD1    HECTD2
    PLEKHA5

    NEDD4 for paralogs           About GeneDecksing



    Genomic Variants
    for NEDD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3069 NCBI SNPs in NEDD4 are shown (see all 3069)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1121130221,2
    		F--56118695(+) GTGGGC/TGGGAG 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1439674201,2
    		--56118740(+) GCCTGA/GGAGGA 2 -- ds50010--------
    rs1841475171,2
    		--56118781(+) CACTCC/TGAACT 2 -- ds50010--------
    rs1164100821,2
    		--56118905(+) TGGCTA/GTTTCA 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1486609351,2
    		--56118925(+) AGACTG/TATGCA 2 -- ds50010--------
    rs797862601,2
    		--56118932(+) TGCAAG/TACGAC 2 -- ds50010--------
    rs787777281,2
    		--56118980(+) AGTTTA/GTAATC 2 -- ds50010--------
    rs1884275141,2
    		--56119029(+) AAAATG/TTAACG 2 -- ds50010--------
    rs1404094041,2
    		--56119227(+) TGATAC/TATATA 2 -- ut310--------
    rs1807755141,2
    		--56119442(+) GCTTGG/TAATTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NEDD4 (56119120 - 56285944 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for NEDD4
         3 CNVs: 53147 76970 35322
         1 Indel: 58728

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEDD4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEDD4

    Disorders / Diseases
    for NEDD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NEDD4 for disorders           About GeneDecksing

    OMIM gene information: 602278    OMIM disorders: --

    20/31 diseases for NEDD4 (see all 31):    About MalaCards
    charcot-marie-tooth disease    human t-cell leukemia virus type 1    non-small cell lung carcinoma    liddle syndrome
    tooth disease    pseudohypoaldosteronism    spinocerebellar ataxia    chronic lymphocytic leukemia
    herpes simplex    cockayne syndrome    lymphocytic leukemia    t-cell leukemia
    prostate cancer, progression of    keloids    lung carcinoma    hepatitis b
    gout    prostate cancer    copd    aldosteronism

    1 disease from the University of Copenhagen DISEASES database for NEDD4:
    Pseudohypoaldosteronism

    6 Novoseek disease relationships for NEDD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liddles syndrome 90.5 13 10074483 (3), 10720933 (2), 8665844 (2), 9792722 (2) (see all 7)
    pseudohypoaldosteronism 66 1 15547682 (1)
    charcot-marie-tooth disease 33.4 2 15776429 (1), 16118794 (1)
    immunodeficiency 4.31 2 15126635 (1), 20164219 (1)
    tumors 0 2 9593687 (1), 16118794 (1)
    cancer 0 2 9990509 (1)

    Human Genome Epidemiology (HuGE) Navigator: NEDD4 (4 documents)

    Export disorders for NEDD4 gene to outside databases

    Publications
    for NEDD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NEDD4 gene, integrated from 9 sources (see all 238):
    (articles sorted by number of sources associating them with NEDD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. (PubMed id 9073511)1, 3, 9 Kumar S....Jenkins N.A. (1997)
    2. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)1, 2, 9 Bouamr F.... Goff S.P. (2003)
    3. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. (PubMed id 21399620)1, 2 Maspero E.... Polo S. (2011)
    4. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. (PubMed id 21765395)1, 2 Persaud A.... Rotin D. (2011)
    5. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 c ontrols neurite development. (PubMed id 20159449)1, 2 Kawabe H....Brose N. (2010)
    6. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK an d regulates epidermal growth factor (EGF)-induced degradation of EGF receptor a nd ACK. (PubMed id 20086093)1, 2 Lin Q....Yang W. (2010)
    7. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. (PubMed id 17218260)1, 2 Wang X.... Jiang X. (2007)
    8. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    9. Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. (PubMed id 8649367)1, 3 Imhof M.O. and McDonnell D.P. (1996)
    10. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)

    External Searches for NEDD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NEDD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4734 HGNC: 7727 AceView: NEDD4 Ensembl:ENSG00000069869 euGenes: HUgn4734
    ECgene: NEDD4 Kegg: 4734 H-InvDB: NEDD4

    Other Databases showing NEDD4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0093

    Specialized Databases showing NEDD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NEDD4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NEDD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NEDD4 gene:
    Search GeneIP for patents involving NEDD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NEDD4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD4
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NEDD4 (NEDD4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NEDD4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NEDD4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NEDD4  
     OriGene Protein Over-expression Lysate for NEDD4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NEDD4   OriGene 3'-UTR Clone for NEDD4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NEDD4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NEDD4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NEDD4   OriGene Custom Protein Services for NEDD4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NEDD4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEDD4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEDD4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NEDD4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NEDD4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NEDD4
     GenScript Custom Purified and Recombinant Proteins Services for NEDD4 GenScript cDNA clones with any tag delivered in your preferred vector for NEDD4
     GenScript Custom Assay Services for NEDD4 GenScript Custom Superior Antibodies Services for NEDD4
     GenScript Custom overexpressing Cell Line Services for NEDD4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NEDD4 
    (NEDD4 iso4)

     Regulatory tfbs in NEDD4 promoter
     Search Chromatin IP Primers for NEDD4
     RT2 qPCR Primer Assay in human, mouse, rat NEDD4
     GNC Network for NEDD4
     SABiosciences PCR Arrays including human, mouse, rat NEDD4
     Search Tocris compounds for NEDD4
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for NEDD4
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NEDD4 antibodies
     NEDD4 proteins
     NEDD4 lysates
     Search for Antibodies for NEDD4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NEDD4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NEDD4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NEDD4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4
     SwitchGear 3'UTR luciferase reporter plasmids for NEDD4
     SwitchGear Promoter luciferase reporter plasmids for NEDD4
     ThermoFisher Antibody for NEDD4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NEDD4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4