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NEDD4 Gene

protein-coding   GIFtS: 71
GCID: GC15M056119

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

(Previous names: neural precursor cell expressed, developmentally down-regulated...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3
Ubiquitin Protein Ligase1 2
     RPF12
Receptor-Potentiating Factor 11 2     E3 Ubiquitin-Protein Ligase NEDD42
Cell Proliferation-Inducing Gene 53 Protein2 3     EC 6.3.2.-3
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 42 3     KIAA00933
NEDD4-12 3     NEDD-43
Neural Precursor Cell Expressed, Developmentally Down-Regulated 41     EC 6.3.28

External Ids:    HGNC: 77271   Entrez Gene: 47342   Ensembl: ENSG000000698697   OMIM: 6022785   UniProtKB: P469343   

Export aliases for NEDD4 gene to outside databases

Previous GC identifers: GC15M051677 GC15M049166 GC15M053698 GC15M053835 GC15M053906 GC15M032943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEDD4 Gene:
NEDD4 (neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with NEDD4 include keloid formation, and pseudohypoaldosteronism type 1. GO annotations related to this gene include ubiquitin binding and ubiquitin-protein ligase activity. An important paralog of this gene is NEDD4L.

UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading
to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at
multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1,
leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According
to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in
PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the
budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal
dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation
of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role
in facilitating viral budding

Gene Wiki entry for NEDD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEDD4 gene promoter:
         AREB6   NF-AT4   NF-AT2   FOXF2   NF-AT3   Nkx2-5   LCR-F1   NF-kappaB1   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEDD4 promoter sequence
   Search Chromatin IP Primers for NEDD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q

NEDD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M056119:  view genomic region     (about GC identifiers)

Start:
56,119,120 bp from pter      End:
56,285,944 bp from pter
Size:
166,825 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NEDD4  
Size: 1319 amino acids; 149114 Da
Subunit: Interacts with UBE2D2. Binds SCNN1A, SCNN1B and SCNN1G. Binds, in vitro, through the WW2 and WW3 domains,
to neural isoforms of ENAH that contain the PPSY motif. Interacts with BEAN1, LITAF, RNF11, WBP1, WBP2, TMEPAI
and PRRG2 (By similarity). Interacts with NDFIP1 and NDFIP2; this interaction activates the E3 ubiquitin-protein
ligase and may induce its recruitment to exosomes (By similarity). Interaction with PTEN is questionable
according to PubMed:18562292. Interacts with viral proteins that contain a late- budding motif P-P-P-Y. This
interaction is essential for viral particle budding of a lot of retroviruses, like HTLV-1 Gag and MLV Gag.
Interacts (via C2 domain) with GRB10 (via SH2 domain). Interacts with ERBB4 (By similarity). Interacts with TNIK;
the interaction is direct, allows the TNIK-dependent recruitment of RAP2A and its ubiquitination by NEDD4.
Interacts (via WW3 domain) with TNK2; EGF promotes this interaction. Interacts (via WW3 domain) with FGFR1 (via
C-terminus). Interacts with OTUD7B. Interacts with ISG15. Interacts (via WW domain) with RAPGEF2; this
interaction leads to ubiquitination and degradation via the proteasome pathway
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAA07655.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for NEDD4 (see all 10):
2KPZ (3D)        2KQ0 (3D)        2M3O (3D)        2XBB (3D)        2XBF (3D)        3B7Y (3D)    
Secondary accessions: A1KY35 A6ND72 A7MD29 B4E2R7 B7ZM59 B7ZM60 B9EGN5 D6RF89
Alternative splicing: 4 isoforms:  P46934-1   P46934-2   P46934-3   P46934-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD4: NX_P46934

Explore proteomics data for NEDD4 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated (By similarity)1
  • Ubiquitination2 at Lys916
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NEDD4 (P46934) (see all 10)
     KNKKEYI  PLPPGWE  TQWEDPR  HLSYFKF 


    See NEDD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001271267.1  NP_001271268.1  NP_001271269.1  NP_006145.2  NP_940682.2  

    ENSEMBL proteins: 
     ENSP00000422455   ENSP00000426051   ENSP00000345530   ENSP00000424827   ENSP00000410613  
     ENSP00000422705   ENSP00000424471   ENSP00000421047  
    Reactome Protein details: P46934

    NEDD4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for NEDD4
    OriGene Custom Protein Services for NEDD4
    GenScript Custom Purified and Recombinant Proteins Services for NEDD4
    Novus Biologicals NEDD4 Protein
    Novus Biologicals NEDD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NEDD4

    NEDD4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NEDD4
    R&D Systems Antibodies for NEDD4
    Cell Signaling Technology (CST) Antibodies for NEDD4  (NEDD4 iso4)
    OriGene Antibodies for NEDD4
    OriGene Custom Antibody Services for NEDD4
    Novus Biologicals NEDD4 Antibodies
    Abcam antibodies for NEDD4
    Cloud-Clone Corp. Antibodies for NEDD4
    ThermoFisher Antibody for NEDD4
    LSBio Antibodies in human, mouse, rat for NEDD4

    NEDD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEDD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NEDD4
    Cloud-Clone Corp. CLIAs for NEDD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000569 HECT
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry P46934

    ProtoNet protein and cluster: P46934

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)


    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Domain: The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2 (By similarity)
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    NEDD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEDD4_HUMAN, P46934
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading
    to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at
    multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1,
    leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According
    to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in
    PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the
    budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal
    dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation
    of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role
    in facilitating viral budding
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding (By similarity)

         Genatlas biochemistry entry for NEDD4:
    neural precursor cell expressed gene 4,developmentally down-regulated 4,expressed in embryonic and adult
    tissues,homolog to ubiquitin-protein ligases (E3) and to yeast RSP5

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA17996703
    GO:0005515protein binding IPI10642508
    GO:0019871sodium channel inhibitor activity IDA10642508
    GO:0019904protein domain specific binding IPI12907594
    GO:0031698beta-2 adrenergic receptor binding IDA18544533
         
    NEDD4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Nedd4):
     cardiovascular system  growth/size/body  hematopoietic system  immune system  mortality/aging 
     nervous system 

    NEDD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NEDD4: Nedd4tm1Bros Nedd4tm2Bros

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NEDD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NEDD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NEDD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NEDD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target NEDD4:
    hsa-let-7b-5p (MIRT001612), hsa-mir-590-3p (MIRT016194), hsa-mir-124-3p (MIRT022426), hsa-mir-30c-5p (MIRT007131)

    Block miRNA regulation of human, mouse, rat NEDD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEDD4 (see all 53):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNEDD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NEDD4
    Predesigned siRNA for gene silencing in human, mouse, rat NEDD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NEDD4

    Clone
    Products:
         
    OriGene clones in human, mouse for NEDD4 (see all 13)
    OriGene ORF clones in mouse, rat for NEDD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NEDD4 (NM_198400)
    Sino Biological Human cDNA Clone for NEDD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NEDD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NEDD4
    Browse ESI BIO Cell Lines and PureStem Progenitors for NEDD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEDD4_HUMAN, P46934: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
    Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R
    internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the
    sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus3
    endosome2
    lysosome2
    vacuole2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ISS--
    GO:0000785chromatin IDA17996703
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IDA12796489
    GO:0005794Golgi apparatus IDA16118794

    NEDD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEDD4 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    3PI-3K cascade
    Signaling by ERBB40.66
    Downregulation of ERBB4 signaling0.00
    4Signaling by GPCR
    Signal Transduction0.58
    5CDK-mediated phosphorylation and removal of Cdc6
    Proteasome Degradation0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NEDD4
        Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for NEDD4
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for NEDD4
        G-protein signaling Rap1A regulation pathway
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    4 BioSystems Pathways for NEDD4
        Proteasome Degradation
    Signaling events mediated by VEGFR1 and VEGFR2
    ErbB4 signaling events
    Presenilin action in Notch and Wnt signaling

    1 Sino Biological Pathway for NEDD4
        Notch Signaling Pathway

    3 Reactome Pathways for NEDD4
        Antigen processing: Ubiquitination & Proteasome degradation
    Downregulation of ERBB4 signaling
    ISG15 antiviral mechanism


    3 Kegg Pathways  (Kegg details for NEDD4):
        Ubiquitin mediated proteolysis
    Endocytosis
    Epstein-Barr virus infection

    UniProtKB/Swiss-Prot: NEDD4_HUMAN, P46934
    Pathway: Protein modification; protein ubiquitination


    NEDD4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NEDD4: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NEDD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEDD4 (P469341, 2, 3 ENSP000003455304) via UniProtKB, MINT, STRING, and/or I2D (see all 284)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1P113621, 2, 3, ENSP000003802804EBI-726944,EBI-1028277 MINT-8290015 MINT-8290063 MINT-8290402 MINT-8289950 MINT-8290027 MINT-8290322 MINT-8290383 MINT-8290051 MINT-8290003 MINT-8290283 MINT-8290560 MINT-8289975 MINT-8290365 MINT-8290238 MINT-8289991 MINT-8290346 MINT-8290605 MINT-8290431 MINT-8290302 MINT-8290170 MINT-8290196 MINT-8292601 MINT-8290629 MINT-8290156 MINT-8290039 MINT-8290263 I2D: score=2 STRING: ENSP00000380280
    HGSO149642, 3, ENSP000003312014MINT-50266 I2D: score=3 STRING: ENSP00000331201
    LAPTM5Q135712, 3, ENSP000002945074MINT-62181 I2D: score=3 STRING: ENSP00000294507
    PTENP604841, 3, ENSP000003610214EBI-726944,EBI-696162 I2D: score=3 STRING: ENSP00000361021
    SCNN1GP511702, 3, ENSP000003000614MINT-17641 I2D: score=3 STRING: ENSP00000300061
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0002250adaptive immune response IEA--
    GO:0003151outflow tract morphogenesis IEA--
    GO:0003197endocardial cushion development IEA--
    GO:0006513protein monoubiquitination IEA--

    NEDD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEDD4

    4 HMDB Compounds for NEDD4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    4 Novoseek inferred chemical compound relationships for NEDD4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 47.5 4 12908109 (1), 11323714 (1), 15123669 (1), 11840194 (1)
    alanine 9.49 1 11352919 (1)
    calcium 0 9 20172859 (3), 10720933 (1), 9073511 (1), 9593687 (1) (see all 5)
    cysteine 0 2 9990509 (1)



    NEDD4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NEDD4 gene (5 alternative transcripts): 
    NM_001284338.1  NM_001284339.1  NM_001284340.1  NM_006154.3  NM_198400.3  

    Unigene Cluster for NEDD4:

    Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    Hs.1565  [show with all ESTs]
    Unigene Representative Sequence: AL832063
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508871 ENST00000503468 ENST00000338963(uc002adi.3) ENST00000508342(uc010ugj.2 uc002adj.3 uc010bfm.3 uc002adk.3)
    ENST00000435532(uc002adl.3) ENST00000506154 ENST00000502612 ENST00000514893
    ENST00000507063 ENST00000513957 ENST00000508075 ENST00000557845
    miRNA
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    Block miRNA regulation of human, mouse, rat NEDD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NEDD4 (see all 53):
    hsa-miR-3607-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNEDD4 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): NEDD4 (NM_198400)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NEDD4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NEDD4
      QuantiTect SYBR Green Assays in human, mouse, rat NEDD4
      QuantiFast Probe-based Assays in human, mouse, rat NEDD4

    Additional mRNA sequence: 

    AK304394.1 AK307541.1 AL832063.1 AL832359.1 AL833293.1 AL833300.1 AY550969.1 BC035707.1 
    BC047035.1 BC136605.1 BC144284.1 BC144285.1 BC152452.1 BC152562.1 D42055.1 

    13 DOTS entries:

    DT.100817363  DT.100817367  DT.100029237  DT.100029236  DT.100723524  DT.121062220  DT.121062254  DT.75178697 
    DT.91745966  DT.92425712  DT.102825738  DT.443258  DT.91925363 

    Selected AceView cDNA sequences (see all 171):

    BM458314 CA413788 AI457332 BU521067 AA442206 BU165030 AW771306 AA441995 
    BM787575 AA434546 BX281486 AI208374 CB115697 AI862157 AV703688 BG492543 
    AI824310 AA362040 AA703450 H57920 AI094191 AL599509 BG577330 BU738662 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NEDD4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                          -           -     -     -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                              -     -     -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:              -     -                           


    ECgene alternative splicing isoforms for NEDD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEDD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCAAGCAA
    NEDD4 Expression
    About this image


    NEDD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Surface Ectoderm (Integumentary System)    fully expand to see all 2 entries
             Surface Ectoderm Cells Surface Ectoderm
             Surface Ectoderm
     
     Ectoderm (Gastrulation Derivatives)
             Surface Ectoderm Cells Surface Ectoderm
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    NEDD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEDD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1565
        Pathway & Disease-focused RT2 Profiler PCR Array including NEDD4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NEDD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NEDD4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd45 neural precursor cell expressed, developmentally down-regulated more   --   9 (40.08 cM) 72662346 
    chicken
    (Gallus gallus)
    Aves NEDD41 neural precursor cell expressed, developmentally down-regulated more 73(n)
    69.73(a)
      415406  XM_004943786.1  XP_004943843.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    47(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039627(1019-5662)
    GL344463.1(20622-34712)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nedd41 neural precursor cell expressed, developmentally down-regulated more 69.12(n)
    66.67(a)
      100496333  XM_004912701.1  XP_004912758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NEDD46
    neural precursor cell expressed, developmentally d...
    56(a)
    1 ↔ 1
    13(52105009-52207985) ENSDARG00000039778
    fruit fly
    (Drosophila melanogaster)
    Insecta Nedd43 protein ubiquitination
    ubiquitin-protein ligase
    50(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y92H12A.23   -- 55(a)   I(1543634-1555890)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSP56
    E3 ubiquitin ligase of the NEDD4 family; involved ...
    36(a)
    1 → many
    V(410189-412618) YER125W


    ENSEMBL Gene Tree for NEDD4 (if available)
    TreeFam Gene Tree for NEDD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NEDD4 gene
    NEDD4L2  HECW22  AREL12  UBR52  WWP22  SMURF22  HECW12  SMURF12  
    HUWE12  WWP12  ITCH2  
    13 SIMAP similar genes for NEDD4 using alignment to 5 protein entries:     NEDD4_HUMAN (see all proteins):
    DKFZp564H223    HECW1    HUWE1    SMURF2    WWP2    DKFZp564G092
    SMURF1    NEDD4L    ITCH    WWP1    HECTD1    UBE3A
    HECTD2

    NEDD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEDD4 (see all 3602)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364724
    A breast cancer sample4--see VAR_0364722 Y H mis40--------
    rs1121130221,2
    F--56118695(+) GTGGGC/TGGGAG 2 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1439674201,2
    C--56118740(+) GCCTGA/GGAGGA 2 -- ds50010--------
    rs1841475171,2
    --56118781(+) CACTCC/TGAACT 2 -- ds50010--------
    rs1164100821,2
    F--56118905(+) TGGCTA/GTTTCA 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1486609351,2
    --56118925(+) AGACTG/TATGCA 2 -- ds50010--------
    rs797862601,2
    C--56118932(+) TGCAAG/TACGAC 2 -- ds50010--------
    rs787777281,2
    F--56118980(+) AGTTTA/GTAATC 2 -- ds50010--------
    rs1884275141,2
    --56119029(+) AAAATG/TTAACG 2 -- ds50010--------
    rs1404094041,2
    --56119227(+) TGATAC/TATATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NEDD4 (56119120 - 56285944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NEDD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749725CNV Deletion23290073
    nsv1543CNV Insertion18451855
    nsv509571CNV Insertion20534489
    dgv319n27CNV Loss19166990
    nsv833017CNV Loss17160897
    nsv819986CNV Loss19587683
    nsv528617CNV Loss19592680
    nsv904245CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NEDD4
    DNA2.0 Custom Variant and Variant Library Synthesis for NEDD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602278    OMIM disorders: --

    Selected diseases for NEDD4 (see all 30):    
    About MalaCards
    keloid formation    pseudohypoaldosteronism type 1    liddle syndrome    pseudohypoaldosteronism
    tooth disease    charcot-marie-tooth disease    cockayne syndrome    human t-cell leukemia virus type 1
    keloids    spinocerebellar ataxia    gout    conjunctivitis
    t-cell leukemia    herpes simplex    ataxia    dementia
    hiv-1    chronic lymphocytic leukemia    breast and colorectal cancer    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for NEDD4:
    Pseudohypoaldosteronism

    NEDD4 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for NEDD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liddles syndrome 90.5 13 10074483 (3), 10720933 (2), 8665844 (2), 9792722 (2) (see all 7)
    pseudohypoaldosteronism 66 1 15547682 (1)
    charcot-marie-tooth disease 33.4 2 15776429 (1), 16118794 (1)
    immunodeficiency 4.31 2 15126635 (1), 20164219 (1)
    tumors 0 2 9593687 (1), 16118794 (1)
    cancer 0 2 9990509 (1)

    Genetic Association Database (GAD): NEDD4
    Human Genome Epidemiology (HuGE) Navigator: NEDD4 (4 documents)

    Export disorders for NEDD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEDD4 gene, integrated from 10 sources (see all 262):
    (articles sorted by number of sources associating them with NEDD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. (PubMed id 11598133)1, 2, 9 Pham N. and Rotin D. (J. Biol. Chem. 2001)
    2. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. (PubMed id 9073511)1, 3, 9 Kumar S....Jenkins N.A. (Genomics 1997)
    3. PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. (PubMed id 14581525)1, 2, 9 Bouamr F.... Goff S.P. (J. Virol. 2003)
    4. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. (PubMed id 21399620)1, 2 Maspero E.... Polo S. (EMBO Rep. 2011)
    5. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. (PubMed id 21765395)1, 2 Persaud A.... Rotin D. (EMBO J. 2011)
    6. A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. (PubMed id 20711176)1, 4 Nakashima M....Zembutsu H. (Nat. Genet. 2010)
    7. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. (PubMed id 20159449)1, 2 Kawabe H.... Brose N. (Neuron 2010)
    8. HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. (PubMed id 20086093)1, 2 Lin Q.... Yang W. (Mol. Cell. Biol. 2010)
    9. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)1, 4 Crowther-Swanepoel D....Houlston R.S. (Nat. Genet. 2010)
    10. ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. (PubMed id 18305167)1, 2 Okumura A....Harty R.N. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4734 HGNC: 7727 AceView: NEDD4 Ensembl:ENSG00000069869 euGenes: HUgn4734
    ECgene: NEDD4 Kegg: 4734 H-InvDB: NEDD4

    (According to HUGE)
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    HUGE: KIAA0093

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEDD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NEDD4 gene:
    Search GeneIP for patents involving NEDD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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