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NEDD1 Gene

protein-coding   GIFtS: 53
GCID: GC12P097301

Neural Precursor Cell Expressed, Developmentally Down-Regulated...

  Search for NEDD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neural Precursor Cell Expressed, Developmentally Down-Regulated 11 2
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 12 3
NEDD-12 3
GCP-WD2
TUBGCP72
Protein NEDD12

External Ids:    HGNC: 77231   Entrez Gene: 1214412   Ensembl: ENSG000001393507   OMIM: 6003725   UniProtKB: Q8NHV43   

Export aliases for NEDD1 gene to outside databases

Previous GC identifers: GC12U990062 GC12P097798 GC12P097233 GC12P095803 GC12P094363


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NEDD1 Gene:
NEDD1 (neural precursor cell expressed, developmentally down-regulated 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: NEDD1_HUMAN, Q8NHV4
Function: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle

Gene Wiki entry for NEDD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NEDD1 gene promoter:
         AREB6   SRF   E2F   E2F-1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNEDD1 promoter sequence
   Search Chromatin IP Primers for NEDD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NEDD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

NEDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEDD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P097301:  view genomic region     (about GC identifiers)

Start:
97,301,001 bp from pter      End:
97,347,469 bp from pter
Size:
46,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEDD1_HUMAN, Q8NHV4 (See protein sequence)
Recommended Name: Protein NEDD1  
Size: 660 amino acids; 71966 Da
Subunit: Interacts with FAM29A and gamma-tubulin
Sequence caution: Sequence=AAH27605.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B0AZN0 B4E145 G3V3F1 Q8NA30
Alternative splicing: 3 isoforms:  Q8NHV4-1   Q8NHV4-2   Q8NHV4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NEDD1: NX_Q8NHV4

Explore proteomics data for NEDD1 at MOPED

Post-translational modifications: 

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382,
    Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the
    gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NEDD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128647.1  NP_001128648.1  NP_001128649.1  NP_690869.1  

    ENSEMBL proteins: 
     ENSP00000266742   ENSP00000404978   ENSP00000450881   ENSP00000451869   ENSP00000450757  
     ENSP00000450828   ENSP00000411307   ENSP00000451830   ENSP00000451211   ENSP00000407964  
    Reactome Protein details: Q8NHV4

    NEDD1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NHV4

    ProtoNet protein and cluster: Q8NHV4

    UniProtKB/Swiss-Prot: NEDD1_HUMAN, Q8NHV4
    Similarity: Contains 8 WD repeats


    Find genes that share domains with NEDD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEDD1_HUMAN, Q8NHV4
    Function: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle

         Genatlas biochemistry entry for NEDD1:
    neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated
    1,with similarities with beta subunit of GTP binding protein,transducin

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NEDD1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NEDD1:
     Cell division defect  Decreased cell number  Decreased viability with pacli  Increased number of mitotic ce 

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate NEDD1 (see all 17):
    hsa-miR-142-5p hsa-miR-429 hsa-miR-944 hsa-miR-570 hsa-miR-9 hsa-miR-3122 hsa-miR-3613-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidNEDD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NEDD1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEDD1_HUMAN, Q8NHV4: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material ----
    GO:0000922spindle pole ----
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005814centriole ----

    Find genes that share ontologies with NEDD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NEDD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with NEDD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Reactome Pathways for NEDD1
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Recruitment of NuMA to mitotic centrosomes
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NEDD1
    Interactions:

        Search GeneGlobe Interaction Network for NEDD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NEDD1 (Q8NHV43 ENSP000004079644) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    CAMKK2Q96RR43I2D: score=1 
    CDK5RAP2ENSP000003438184STRING: ENSP00000343818
    CENPJENSP000003713084STRING: ENSP00000371308
    CEP135ENSP000002572874STRING: ENSP00000257287
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with NEDD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NEDD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NEDD1 gene (4 alternative transcripts): 
    NM_001135175.1  NM_001135176.1  NM_001135177.1  NM_152905.3  

    Unigene Cluster for NEDD1:

    Neural precursor cell expressed, developmentally down-regulated 1
    Hs.270084  [show with all ESTs]
    Unigene Representative Sequence: NM_152905
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266742(uc001teu.4 uc001tev.4 uc010svc.2 uc001tew.3)
    ENST00000429527 ENST00000554226 ENST00000557478 ENST00000557092 ENST00000555806
    ENST00000555114 ENST00000411739 ENST00000557400 ENST00000553609 ENST00000557454
    ENST00000557644 ENST00000457368(uc001tex.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NEDD1 (see all 17):
    hsa-miR-142-5p hsa-miR-429 hsa-miR-944 hsa-miR-570 hsa-miR-9 hsa-miR-3122 hsa-miR-3613-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidNEDD1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NEDD1
      QuantiFast Probe-based Assays in human, mouse, rat NEDD1

    Additional mRNA sequence: 

    AK093221.1 AK290058.1 AK303656.1 AK315821.1 AL832466.1 BC020799.1 BC026168.1 BC027605.2 

    8 DOTS entries:

    DT.91650923  DT.212555  DT.100020567  DT.97767745  DT.121165391  DT.100774627  DT.91709234  DT.100774626 

    Selected AceView cDNA sequences (see all 96):

    BM452392 AW299344 NM_152905 BQ230403 BC020799 BC027605 BX280462 BU153549 
    BM716600 BM771394 AA258261 AA236743 AI915033 AA236927 AA236732 AA470029 
    BP375250 BM470667 AK093221 BP364313 BM559919 BG288545 AA412216 CB043864 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                          -     -     -           -                                                                                                         
    SP2:                                      -           -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                          -                 -     -     -                                                                                                   

    ExUns: 16b · 16c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for NEDD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NEDD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NEDD1 Expression
    About this image


    NEDD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Telencephalon
    NEDD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NEDD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270084
        Custom PCR Arrays for NEDD1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEDD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NEDD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nedd11 , 5 neural precursor cell expressed, developmentally down-regulated more1, 5 85.2(n)1
    85.45(a)1
      10 (47.25 cM)5
    179971  NM_008682.21  NP_032708.21 
     926847455 
    chicken
    (Gallus gallus)
    Aves NEDD11 neural precursor cell expressed, developmentally down-regulated more 69.93(n)
    67.23(a)
      417922  NM_001030750.1  NP_001025921.1 
    lizard
    (Anolis carolinensis)
    Reptilia NEDD16
    neural precursor cell expressed, developmentally d...
    61(a)
    1 ↔ 1
    5(30138645-30170939)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243932 Xenopus laevis transcribed sequence with weak similarity more 78.01(n)    BJ624975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb78g032 Danio rerio cDNA clone MGC63491 IMAGE2639349, complete more 69.03(n)    BC058053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Grip716
    Grip71
    15(a)
    1 ↔ 1
    2L(18708849-18711297)


    ENSEMBL Gene Tree for NEDD1 (if available)
    TreeFam Gene Tree for NEDD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NEDD1 (see all 957)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs789715861,2
    C--97299057(+) ACTGAG/CAAAAT 3 -- us2k12Minor allele frequency- C:0.17NA EA 122
    rs1388235341,2
    --97299152(+) CTTACA/GTTCAC 3 -- us2k10--------
    rs65387501,2
    C,F,A--97299298(+) TATTAT/GCAAGG 4 -- us2k19Minor allele frequency- G:0.44NA WA CSA EA 370
    rs1176663451,2
    F--97299316(+) CATTTG/AGCATC 4 -- us2k11Minor allele frequency- A:0.01EA 120
    rs20244901,2
    C,F,O,H--97299364(-) ATGTAC/TACACT 4 -- us2k124Minor allele frequency- T:0.05MN NS EA NA WA CSA 2535
    rs1493706781,2
    --97299433(+) AGGCCA/GCAGCA 4 -- us2k10--------
    rs1165209041,2
    F--97299442(+) CATCAG/CTGAGG 4 -- us2k11Minor allele frequency- C:0.02WA 118
    rs778848841,2
    C,F--97299449(+) GAGGAC/TAGAGG 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1440731781,2
    --97299572(+) ACCATG/TTATTA 4 -- us2k10--------
    rs1869615991,2
    --97299609(+) AACCTC/GTATTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for NEDD1 (97301001 - 97347469 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NEDD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2136665CNV Deletion18987734
    esv2507346CNV Insertion19546169
    esv7477CNV Gain19470904
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NEDD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600372    OMIM disorders: --


    Find genes that share disorders with NEDD1           About GenesLikeMe

    Genetic Association Database (GAD): NEDD1

    Export disorders for NEDD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NEDD1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with NEDD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PubMed id 19509060)1, 2 Zhang X....Zhang C. (J. Cell Sci. 2009)
    2. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PubMed id 19029337)1, 2 Zhu H.... Fang G. (J. Cell Biol. 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function. (PubMed id 23273898)1 Pinyol R....Vernos I. (Curr. Biol. 2013)
    6. Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice. (PubMed id 23106787)1 Fujita T....Sasaki H. (Cancer Sci. 2013)
    7. Genetic variants associated with breast size also influence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (BMC Med. Genet. 2012)
    8. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. (PubMed id 22895009)1 Gomez-Ferreria M.A....Pelletier L. (Cell Cycle 2012)
    9. Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of I^-tubulin recruitment to the mitotic centrosome. (PubMed id 22818914)1 Sdelci S....Roig J. (Curr. Biol. 2012)
    10. Novel NEDD1 phosphorylation sites regulate I^-tubulin binding and mitotic spindle assembly. (PubMed id 22595525)1 Gomez-Ferreria M.A....Pelletier L. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121441 HGNC: 7723 AceView: NEDD1 Ensembl:ENSG00000139350 euGenes: HUgn121441
    ECgene: NEDD1 H-InvDB: NEDD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NEDD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NEDD1 gene:
    Search GeneIP for patents involving NEDD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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