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Aliases for NEDD1 Gene

Aliases for NEDD1 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 3 4
  • NEDD-1 3 4
  • Protein NEDD1 3
  • TUBGCP7 3
  • GCP-WD 3

External Ids for NEDD1 Gene

Previous GeneCards Identifiers for NEDD1 Gene

  • GC12U990062
  • GC12P097798
  • GC12P097233
  • GC12P095803
  • GC12P094363
  • GC12P097301

Summaries for NEDD1 Gene

GeneCards Summary for NEDD1 Gene

NEDD1 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 1) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for NEDD1 Gene

  • Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Gene Wiki entry for NEDD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD1 Gene

Genomics for NEDD1 Gene

Regulatory Elements for NEDD1 Gene

Enhancers for NEDD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F096906 1.1 ENCODE 54.5 +0.2 233 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207 NEDD1 GC12M096855
GH12F096033 1.2 ENCODE 32.6 -872.0 -871985 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 NEDD1 ELK3 HAL PGAM1P5 LOC102723340 ENSG00000258272 ENSG00000258313 ENSG00000202368 ENSG00000257470 NTN4
GH12F096889 0.8 Ensembl ENCODE 44.2 -17.2 -17203 1.9 CTCF JUND JUN FOS CREM NEDD1 EEF1A1P33 GC12P096819
GH12F096980 0.9 Ensembl ENCODE 26.8 +73.8 73831 1.4 JUND RFX1 ZNF366 JUN BHLHE40 FOS BMI1 PRDM1 NEDD1 ENSG00000202368 GC12M096980 LOC105369928
GH12F096419 1.7 FANTOM5 Ensembl ENCODE 14.1 -481.3 -481344 12.6 PKNOX1 ZFP64 ZNF493 SIN3A BRCA1 GTF3C2 ZNF121 KLF7 ZNF548 FOS ELK3 NEDD1 CDK17 CFAP54 METAP2 SNRPF USP44 RN7SKP11 GC12P096416
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NEDD1 on UCSC Golden Path with GeneCards custom track

Promoters for NEDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000245656 78 2200 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for NEDD1 Gene

96,907,223 bp from pter
96,953,777 bp from pter
46,555 bases
Plus strand

Genomic View for NEDD1 Gene

Genes around NEDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD1 Gene

Proteins for NEDD1 Gene

  • Protein details for NEDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NEDD1
    Protein Accession:
    Secondary Accessions:
    • B0AZN0
    • B4E145
    • G3V3F1
    • Q8NA30

    Protein attributes for NEDD1 Gene

    660 amino acids
    Molecular mass:
    71966 Da
    Quaternary structure:
    • Interacts with FAM29A and gamma-tubulin.
    • Sequence=AAH27605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEDD1 Gene


neXtProt entry for NEDD1 Gene

Post-translational modifications for NEDD1 Gene

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD1 Gene

Domains & Families for NEDD1 Gene

Gene Families for NEDD1 Gene

Protein Domains for NEDD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 WD repeats.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with NEDD1: view

Function for NEDD1 Gene

Molecular function for NEDD1 Gene

GENATLAS Biochemistry:
neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated 1,with similarities with beta subunit of GTP binding protein,transducin
UniProtKB/Swiss-Prot Function:
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
genes like me logo Genes that share phenotypes with NEDD1: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD1 Gene

Localization for NEDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NEDD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IBA --
GO:0000922 spindle pole IBA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NEDD1: view

Pathways & Interactions for NEDD1 Gene

genes like me logo Genes that share pathways with NEDD1: view

Gene Ontology (GO) - Biological Process for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
GO:0071539 protein localization to centrosome IBA --
genes like me logo Genes that share ontologies with NEDD1: view

No data available for SIGNOR curated interactions for NEDD1 Gene

Transcripts for NEDD1 Gene

Unigene Clusters for NEDD1 Gene

Neural precursor cell expressed, developmentally down-regulated 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - -
SP3: -
SP5: - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - - -

ExUns: 16b · 16c

Relevant External Links for NEDD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NEDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NEDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Plasma (12.6), Fetal heart (8.2), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NEDD1 Gene

Protein tissue co-expression partners for NEDD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NEDD1 Gene:


SOURCE GeneReport for Unigene cluster for NEDD1 Gene:

genes like me logo Genes that share expression patterns with NEDD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NEDD1 Gene

Orthologs for NEDD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NEDD1 34 35
  • 99.34 (n)
(Canis familiaris)
Mammalia NEDD1 34 35
  • 91.49 (n)
(Bos Taurus)
Mammalia NEDD1 34 35
  • 91.15 (n)
(Mus musculus)
Mammalia Nedd1 34 16 35
  • 85.2 (n)
(Rattus norvegicus)
Mammalia Nedd1 34
  • 84.17 (n)
(Monodelphis domestica)
Mammalia NEDD1 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NEDD1 35
  • 72 (a)
(Gallus gallus)
Aves NEDD1 34 35
  • 69.93 (n)
(Anolis carolinensis)
Reptilia NEDD1 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd1 34
  • 66.11 (n)
Str.17693 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24393 34
(Danio rerio)
Actinopterygii nedd1 34 35
  • 56.16 (n)
wufb78g03 34
fruit fly
(Drosophila melanogaster)
Insecta Grip71 35
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for NEDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD1 Gene

Gene Tree for NEDD1 (if available)
Gene Tree for NEDD1 (if available)

Paralogs for NEDD1 Gene

No data available for Paralogs for NEDD1 Gene

Variants for NEDD1 Gene

Sequence variations from dbSNP and Humsavar for NEDD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10431407 -- 96,922,730(+) ttggt(A/G)taact intron-variant
rs10431408 -- 96,937,441(+) TTTTT(G/T)TTTTT intron-variant
rs10431438 -- 96,922,079(+) TTTGG(A/G)AGGTA intron-variant
rs10431439 -- 96,937,442(+) TTTTG(A/G/T)TTTTT intron-variant
rs1044910 -- 96,953,146(+) AAACT(A/G)TGTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NEDD1 Gene

Variant ID Type Subtype PubMed ID
esv2136665 CNV deletion 18987734
esv2507346 CNV insertion 19546169
esv7477 CNV gain 19470904
nsv7234 OTHER inversion 18451855

Variation tolerance for NEDD1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD1 Gene

Disorders for NEDD1 Gene

Relevant External Links for NEDD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NEDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD1 Gene

Publications for NEDD1 Gene

  1. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PMID: 19509060) Zhang X. … Zhang C. (J. Cell Sci. 2009) 3 4 64
  2. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. (PMID: 19029337) Zhu H. … Fang G. (J. Cell Biol. 2008) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64

Products for NEDD1 Gene

Sources for NEDD1 Gene

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