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Aliases for NEDD1 Gene

Aliases for NEDD1 Gene

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 1 2 3 5
  • Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 3 4
  • NEDD-1 3 4
  • TUBGCP7 3
  • GCP-WD 3

External Ids for NEDD1 Gene

Previous GeneCards Identifiers for NEDD1 Gene

  • GC12U990062
  • GC12P097798
  • GC12P097233
  • GC12P095803
  • GC12P094363
  • GC12P097301

Summaries for NEDD1 Gene

GeneCards Summary for NEDD1 Gene

NEDD1 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for NEDD1 Gene

  • Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Gene Wiki entry for NEDD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NEDD1 Gene

Genomics for NEDD1 Gene

Regulatory Elements for NEDD1 Gene

Promoters for NEDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NEDD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NEDD1 Gene

Chromosome:
12
Start:
96,907,223 bp from pter
End:
96,953,777 bp from pter
Size:
46,555 bases
Orientation:
Plus strand

Genomic View for NEDD1 Gene

Genes around NEDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NEDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NEDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NEDD1 Gene

Proteins for NEDD1 Gene

  • Protein details for NEDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV4-NEDD1_HUMAN
    Recommended name:
    Protein NEDD1
    Protein Accession:
    Q8NHV4
    Secondary Accessions:
    • B0AZN0
    • B4E145
    • G3V3F1
    • Q8NA30

    Protein attributes for NEDD1 Gene

    Size:
    660 amino acids
    Molecular mass:
    71966 Da
    Quaternary structure:
    • Interacts with FAM29A and gamma-tubulin.
    SequenceCaution:
    • Sequence=AAH27605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NEDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NEDD1 Gene

Proteomics data for NEDD1 Gene at MOPED

Post-translational modifications for NEDD1 Gene

  • During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NEDD1 Gene

Domains & Families for NEDD1 Gene

Gene Families for NEDD1 Gene

Protein Domains for NEDD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHV4

UniProtKB/Swiss-Prot:

NEDD1_HUMAN :
  • Contains 8 WD repeats.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with NEDD1: view

Function for NEDD1 Gene

Molecular function for NEDD1 Gene

GENATLAS Biochemistry:
neural precursor cell expressed gene 1,71kDa,strongly expressed in embryonic brain developmentally downregulated 1,with similarities with beta subunit of GTP binding protein,transducin
UniProtKB/Swiss-Prot Function:
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
genes like me logo Genes that share phenotypes with NEDD1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NEDD1 Gene

Localization for NEDD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NEDD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NEDD1 Gene COMPARTMENTS Subcellular localization image for NEDD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IBA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0036064 ciliary basal body IBA --
genes like me logo Genes that share ontologies with NEDD1: view

Pathways & Interactions for NEDD1 Gene

genes like me logo Genes that share pathways with NEDD1: view

Interacting Proteins for NEDD1 Gene

Gene Ontology (GO) - Biological Process for NEDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
GO:0071539 protein localization to centrosome IBA --
genes like me logo Genes that share ontologies with NEDD1: view

No data available for SIGNOR curated interactions for NEDD1 Gene

Drugs & Compounds for NEDD1 Gene

No Compound Related Data Available

Transcripts for NEDD1 Gene

Unigene Clusters for NEDD1 Gene

Neural precursor cell expressed, developmentally down-regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NEDD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: - - - - -
SP8: - - - - - - -

ExUns: 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NEDD1 Gene

GeneLoc Exon Structure for
NEDD1
ECgene alternative splicing isoforms for
NEDD1

Expression for NEDD1 Gene

mRNA expression in normal human tissues for NEDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NEDD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.3), Plasma (12.6), Fetal heart (8.2), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NEDD1 Gene



SOURCE GeneReport for Unigene cluster for NEDD1 Gene Hs.270084

genes like me logo Genes that share expression patterns with NEDD1: view

Protein tissue co-expression partners for NEDD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NEDD1 Gene

Orthologs for NEDD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NEDD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NEDD1 36
  • 99 (a)
OneToOne
NEDD1 35
  • 99.34 (n)
  • 99.24 (a)
cow
(Bos Taurus)
Mammalia NEDD1 36
  • 91 (a)
OneToOne
NEDD1 35
  • 91.15 (n)
  • 90.74 (a)
dog
(Canis familiaris)
Mammalia NEDD1 35
  • 91.49 (n)
  • 90.12 (a)
NEDD1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nedd1 16
Nedd1 35
  • 85.2 (n)
  • 85.45 (a)
Nedd1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NEDD1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NEDD1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nedd1 35
  • 84.17 (n)
  • 85.89 (a)
chicken
(Gallus gallus)
Aves NEDD1 35
  • 69.93 (n)
  • 67.23 (a)
NEDD1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NEDD1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24393 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nedd1 35
  • 66.11 (n)
  • 62.5 (a)
Str.17693 35
zebrafish
(Danio rerio)
Actinopterygii nedd1 36
  • 45 (a)
OneToOne
nedd1 35
  • 56.16 (n)
  • 51.77 (a)
wufb78g03 35
fruit fly
(Drosophila melanogaster)
Insecta Grip71 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for NEDD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NEDD1 Gene

ENSEMBL:
Gene Tree for NEDD1 (if available)
TreeFam:
Gene Tree for NEDD1 (if available)

Paralogs for NEDD1 Gene

No data available for Paralogs for NEDD1 Gene

Variants for NEDD1 Gene

Sequence variations from dbSNP and Humsavar for NEDD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs249576 -- 96,937,587(+) AAATG(A/T)TAAAA intron-variant
rs249588 -- 96,945,265(+) ATTTT(A/G)CTTGA intron-variant
rs249589 -- 96,945,610(-) ATGTG(C/G)AAACT intron-variant
rs249590 -- 96,946,754(-) CTATT(C/T)TACTG intron-variant
rs249591 -- 96,947,704(+) TGCCC(C/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NEDD1 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv2136665 CNV Deletion 18987734
esv7477 CNV Gain 19470904
esv2507346 CNV Insertion 19546169

Variation tolerance for NEDD1 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NEDD1 Gene

HapMap Linkage Disequilibrium report
NEDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NEDD1 Gene

Disorders for NEDD1 Gene

Relevant External Links for NEDD1

Genetic Association Database (GAD)
NEDD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NEDD1

No disorders were found for NEDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NEDD1 Gene

Publications for NEDD1 Gene

  1. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PMID: 19509060) Zhang X. … Zhang C. (J. Cell Sci. 2009) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  5. Common genetic variants on 1p13.2 associate with risk of autism. (PMID: 24189344) Xia K. … Zhang F. (Mol. Psychiatry 2014) 3

Products for NEDD1 Gene

Sources for NEDD1 Gene

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